                         SEQUENCE LISTING

<110>  CEDARS-SINAI MEDICAL CENTER
       KOEFFLER, H. Phillip
       GERY, Sigal
 
<120>  TREATMENT OF MYELOPROLIFERATIVE DISORDERS WITH ADAPTOR PROTEIN 
       LNK

<130>  67789-1089

<150>  60/915,069
<151>  2007-04-30

<150>  60/915,341
<151>  2007-05-01

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  5423
<212>  DNA
<213>  Homo sapiens

<400>  1
cccgggccac cgcctccgcc cggctgcccg cccggactgt cgcggcccgc ggtggcgacg       60

gcggccgctg caaagtttcc ccggcggcgg cggcccgggg gcgcatcctc ccgcaactgt      120

caagcgctgg cggcggaaat gatgaggcgc tggccatttt ccgagcccgg gtttcctgcc      180

tgagccccgc tcgagcgagc cgcgagcgag gagccggcgg gcgggagagg acgcgcccag      240

ggcgggggcc cgcccgcccc ctcgggattt cgagggcccg ggggcgcgcg acgccatggg      300

ccggccgggc ccagagctcc tgtctctcag cccggccgca ccacctgggt ctccgccatg      360

aacgggcctg ccctgcagcc ctcctcgccc tcttccgcgc cctcagcctc cccggcggcg      420

gccccgcggg gctggagcga gttctgtgag ttgcacgccg tagcggcggc ccgggagctg      480

gcccgccagt actggctgtt cgcccgggag catccgcagc acgcgccgct gcgcgccgag      540

ctggtgtcgc tgcagttcac cgacctcttc cagcgctact tctgccgcga ggtgcgcgac      600

ggacgggcgc cgggccgcga ctaccgggac acaggccgtg ggcccccagc caaggccgag      660

gcgtccccgg agccaggccc cggccccgcc gcccctggcc tgcccaaggc ccgcagctct      720

gaggagctgg ccccgccgcg gccgcccggg ccctgctcct tccagcactt tcgccgcagc      780

ctccgccaca tcttccgccg ccgctcggcc ggggagctgc cagcggccca caccgctgcc      840

gcccccggga cccccggaga ggctgctgag acccccgccc ggcctggcct ggccaagaag      900

ttcctgccct ggagcctggc ccgggagccg ccacccgagg cgctgaagga ggcggtgctg      960

cgctacagcc tggccgacga ggcctccatg gacagcgggg cacgctggca gcgcgggagg     1020

ctggcgctgc gccgggcccc gggccccgat ggccccgacc gcgtgctgga gctcttcgac     1080

ccacccaaga gttcaaggcc caagctacaa gcagcttgct ccagcatcca ggaggtccgg     1140

tggtgcacac ggcttgagat gcctgacaac ctttacacct ttgtgctgaa ggtgaaggac     1200

cggacagaca tcatctttga ggtgggagac gagcagcagc tgaattcatg gatggctgag     1260

ctctcggagt gcacaggccg agggctggag agcacagaag cagagatgca tattccctca     1320

gccctagagc ctagcacgtc cagctcccca aggggcagca cagattccct taaccaaggt     1380

gcttctcctg gggggctgct ggacccggcc tgccagaaga cggaccattt cctgtcctgc     1440

tacccctggt tccacggccc catctccaga gtgaaagcag ctcagctggt tcagctgcag     1500

ggccctgatg ctcatggagt gttcctggtg cggcagagcg agacgcggcg tggggaatac     1560

gtgctcactt tcaactttca ggggatagcc aagcacctgc gcctgtcgct gacagagcgg     1620

ggccagtgcc gtgtgcagca cctccacttt ccctcggtcg tggacatgct ccaccacttc     1680

cagcgctcgc ccatcccact cgagtgcggc gccgcctgtg atgtccggct ctccagctac     1740

gtggtagtcg tctcccaacc accaggttcc tgcaacacgg tcctcttccc tttctccctt     1800

cctcactggg attcagagtc ccttcctcac tggggttcag agttgggcct tccccacctt     1860

agttcttctg gctgtccccg ggggctcagc ccagagggtc tcccagggcg atcctcaccc     1920

cccgagcaga tcttccacct ggtgccttcg cccgaagaac tggccaacag cctgcagcac     1980

ctggagcatg agcctgtgaa tcgagcccgg gactcggact acgaaatgga ctcatcctcc     2040

cggagccacc tgcgggccat agacaatcag tacacacctc tctgaccagt gaggaattcc     2100

aggcctcaac agctgccctt gaggagcaca ggcagaagtg tgaacttgtg aatgtaattg     2160

atctttcctt ccttccagag aaagatttaa gggacactgt taactgctcg tgccagtttg     2220

gaagtgaccc ttctattagg cctgttgaag ggccctcctg taggtttcat ctatccacct     2280

ggctttctcc ttattgttta cagatgtagt tcttgttaga ggatgccgct agctcctgcc     2340

cggggtccct atgcccagtc cccgttactc ttagagaaag gagttggggt gagggccaga     2400

gctggcagtg gaaacttgtt ctctttttca ctgacactgt cacagcggat gacagacttt     2460

ctacggggag gaggggggga tcatcaggaa gcccagaaca ctaacaagcg gttctcccat     2520

ctaccgtcag tccacatggc aggtctgctg tgtccacacc acagatgacc acatctaatc     2580

ctgcttctac tctcagcttt aggacaaaag ctctgtcaga ggcacaagct gaaggtcaaa     2640

aatgatttaa aacattttac ctcagactaa tttctttaaa ggattcaggt tcaaaactta     2700

accactgctt atttcagtgc actgtttcaa ctaacaccca tgctattttt gtagtcagaa     2760

acagctatgc aaaccctacc taatttacag tctgagccag catgctggct tgtctactgc     2820

atcctcggga cagtcacctg ccactgagtg gccactgtcc ttcctaaatg tcaagaagtg     2880

aagtatgtca ccctttcagg gaaattcagg caattactga aataggaagg tggcaagaac     2940

agttctatcc tggtgcctta cgaataaaaa actggattct ggtttacagc agctttacag     3000

tgatagttaa attaactggg gctaggggaa aagcaaccaa aaagggaaaa aggactccta     3060

ggccctttct attaaatcct tcagcaacaa ggctggcttg gtgccctcca agcatctaat     3120

ggcttattaa attatcccac aattgggttt taggctcctt ttttgaccca aaatggaagc     3180

tgggaatctg gtgccataac taatgagaaa ctcctttaat accccacaat cagtgttctg     3240

ttctacctgg ctactgcttc actggattga aaatctatct atctccttgc acacatgggc     3300

acacacaatc tccaccatcc agggaggtcc tgaattcaaa tctctatcta tccaagtgat     3360

acaattcata gggggctggc tcctcccaga acctgtctgg aggctcagaa acgggggcag     3420

tgacagtgga gtcagctgct cttgggtgcc agcagagcca ttcagtacaa cccccaggct     3480

cacagcagtg gcttctagga aactgggagt ttagatcagc tttacagata catcgatcag     3540

aggctaaaat gaaacctcag cctaaaactc ataggactga ctgcctggga ggagggttag     3600

gtctgcttct tccacttata cttagtctct gtgctccaag aggtcaaatt tttgcttcta     3660

gaatttcctt ggggtctttc agagggtggg ggaacaaacc cctatgcact tttctttttt     3720

ttttttgaga tggagtttct cttgtcaacc gggctggagt gcagtggtgc aatcttggct     3780

cactgcaacc tccaccttcc tggttcaagc gattctgcct cgacctctca agtagctggg     3840

attacaagca ccagccacca tgcctggcta attttgtatt tttagtagag acagggtttc     3900

accatgttgg ccaggctggt ctcgaatgtc tgacctcagg tgatccaccc gccttggcct     3960

cccaaagtgc tgggattaca ggcgcgagcc accgcgccca gcctacacca cttttagtac     4020

caacactctt gggtgatttc atggacccta aagcagacct gacactgatc cagatttgca     4080

gtccattttt aaggacacct gtctttattt cctcaaagtc aagcagcttt ctctggaaaa     4140

tgaatgctaa ttagtgtgaa ccaaaagagt aagtaagagt ctgaagtttt tttaaaggag     4200

aaagcttatt atggaaagtc actggtcctc ccctccgcac aggaaaggta cccagtagat     4260

aatgaaccaa attaagttcc ctccctccag ccagaagtta aacatctggg atatgacgtc     4320

ttcatgccag gggcactcat ttcttagcag cctctctaca tacatctctc aggtggtgcc     4380

aagaggcaca ccaggtagag caaacttagc agctctgact aacaggctgc aaagtgcaag     4440

ttcagattct gtggcagaga tttggagggc acccacgtcc agactgcttc ccgtccaagt     4500

taccaggaca gctcaaaaac atgctgacag aaaactccca tggctctagg aaaaagtgac     4560

actaagccaa cacctttctt tatgtgggag caaaatcagc tgatgaaggg gtgggcacca     4620

ttgtggggca ggcaccccac tggctgcagc tagcccacca taggcacagc acatcccacc     4680

actctccttc cagtcctgac caggccccag ccggcaactt ctaccgagag ccatggctca     4740

acaccaaact ggacagtaga catcatgatc cctccagtta gctctaatta cagaccccac     4800

cagtacagct tgacagctcc cggcaccatc ccttccttca tctgacttat tgaactttta     4860

caaactaaca gtcaccagca ccaaagaatt aagtcaacta acctgccttg aattttaaac     4920

cagcaatcca tatggcttta tctggtataa atcttctgcc tttgatcatt tctggaccgt     4980

aggaaaaagg aatagcaatc attaaaatct tgggccagag aacactattt ttacataaca     5040

gtttcttaac ctaaagtcaa ggccttggac tcttccctga gggttgcctg aaattccttc     5100

atgctttcta ttcaggacta attcccttac tgcaaatgtg ttagctctaa catctcccac     5160

aagctaaagg aacttgcaag tatattaaca aggacacatc tgacatcctg tgtttggtta     5220

aaatatacag cacattgtga taacataaag tggatccatc ttgtatcatt ataggcaaaa     5280

ggtatttggc aaatttttat gtatggtttt atgtactgta caagtaactt attcttgaat     5340

aatgcaaatt ttgctataat gtacaaattg ctatatgtga attaaaaagt ttccaaaatc     5400

ttgaaaaaaa aaaaaaaaaa aaa                                             5423


<210>  2
<211>  5423
<212>  DNA
<213>  Homo sapiens

<400>  2
tttttttttt tttttttttt caagattttg gaaacttttt aattcacata tagcaatttg       60

tacattatag caaaatttgc attattcaag aataagttac ttgtacagta cataaaacca      120

tacataaaaa tttgccaaat accttttgcc tataatgata caagatggat ccactttatg      180

ttatcacaat gtgctgtata ttttaaccaa acacaggatg tcagatgtgt ccttgttaat      240

atacttgcaa gttcctttag cttgtgggag atgttagagc taacacattt gcagtaaggg      300

aattagtcct gaatagaaag catgaaggaa tttcaggcaa ccctcaggga agagtccaag      360

gccttgactt taggttaaga aactgttatg taaaaatagt gttctctggc ccaagatttt      420

aatgattgct attccttttt cctacggtcc agaaatgatc aaaggcagaa gatttatacc      480

agataaagcc atatggattg ctggtttaaa attcaaggca ggttagttga cttaattctt      540

tggtgctggt gactgttagt ttgtaaaagt tcaataagtc agatgaagga agggatggtg      600

ccgggagctg tcaagctgta ctggtggggt ctgtaattag agctaactgg agggatcatg      660

atgtctactg tccagtttgg tgttgagcca tggctctcgg tagaagttgc cggctggggc      720

ctggtcagga ctggaaggag agtggtggga tgtgctgtgc ctatggtggg ctagctgcag      780

ccagtggggt gcctgcccca caatggtgcc caccccttca tcagctgatt ttgctcccac      840

ataaagaaag gtgttggctt agtgtcactt tttcctagag ccatgggagt tttctgtcag      900

catgtttttg agctgtcctg gtaacttgga cgggaagcag tctggacgtg ggtgccctcc      960

aaatctctgc cacagaatct gaacttgcac tttgcagcct gttagtcaga gctgctaagt     1020

ttgctctacc tggtgtgcct cttggcacca cctgagagat gtatgtagag aggctgctaa     1080

gaaatgagtg cccctggcat gaagacgtca tatcccagat gtttaacttc tggctggagg     1140

gagggaactt aatttggttc attatctact gggtaccttt cctgtgcgga ggggaggacc     1200

agtgactttc cataataagc tttctccttt aaaaaaactt cagactctta cttactcttt     1260

tggttcacac taattagcat tcattttcca gagaaagctg cttgactttg aggaaataaa     1320

gacaggtgtc cttaaaaatg gactgcaaat ctggatcagt gtcaggtctg ctttagggtc     1380

catgaaatca cccaagagtg ttggtactaa aagtggtgta ggctgggcgc ggtggctcgc     1440

gcctgtaatc ccagcacttt gggaggccaa ggcgggtgga tcacctgagg tcagacattc     1500

gagaccagcc tggccaacat ggtgaaaccc tgtctctact aaaaatacaa aattagccag     1560

gcatggtggc tggtgcttgt aatcccagct acttgagagg tcgaggcaga atcgcttgaa     1620

ccaggaaggt ggaggttgca gtgagccaag attgcaccac tgcactccag cccggttgac     1680

aagagaaact ccatctcaaa aaaaaaaaag aaaagtgcat aggggtttgt tcccccaccc     1740

tctgaaagac cccaaggaaa ttctagaagc aaaaatttga cctcttggag cacagagact     1800

aagtataagt ggaagaagca gacctaaccc tcctcccagg cagtcagtcc tatgagtttt     1860

aggctgaggt ttcattttag cctctgatcg atgtatctgt aaagctgatc taaactccca     1920

gtttcctaga agccactgct gtgagcctgg gggttgtact gaatggctct gctggcaccc     1980

aagagcagct gactccactg tcactgcccc cgtttctgag cctccagaca ggttctggga     2040

ggagccagcc ccctatgaat tgtatcactt ggatagatag agatttgaat tcaggacctc     2100

cctggatggt ggagattgtg tgtgcccatg tgtgcaagga gatagataga ttttcaatcc     2160

agtgaagcag tagccaggta gaacagaaca ctgattgtgg ggtattaaag gagtttctca     2220

ttagttatgg caccagattc ccagcttcca ttttgggtca aaaaaggagc ctaaaaccca     2280

attgtgggat aatttaataa gccattagat gcttggaggg caccaagcca gccttgttgc     2340

tgaaggattt aatagaaagg gcctaggagt cctttttccc tttttggttg cttttcccct     2400

agccccagtt aatttaacta tcactgtaaa gctgctgtaa accagaatcc agttttttat     2460

tcgtaaggca ccaggataga actgttcttg ccaccttcct atttcagtaa ttgcctgaat     2520

ttccctgaaa gggtgacata cttcacttct tgacatttag gaaggacagt ggccactcag     2580

tggcaggtga ctgtcccgag gatgcagtag acaagccagc atgctggctc agactgtaaa     2640

ttaggtaggg tttgcatagc tgtttctgac tacaaaaata gcatgggtgt tagttgaaac     2700

agtgcactga aataagcagt ggttaagttt tgaacctgaa tcctttaaag aaattagtct     2760

gaggtaaaat gttttaaatc atttttgacc ttcagcttgt gcctctgaca gagcttttgt     2820

cctaaagctg agagtagaag caggattaga tgtggtcatc tgtggtgtgg acacagcaga     2880

cctgccatgt ggactgacgg tagatgggag aaccgcttgt tagtgttctg ggcttcctga     2940

tgatcccccc ctcctccccg tagaaagtct gtcatccgct gtgacagtgt cagtgaaaaa     3000

gagaacaagt ttccactgcc agctctggcc ctcaccccaa ctcctttctc taagagtaac     3060

ggggactggg catagggacc ccgggcagga gctagcggca tcctctaaca agaactacat     3120

ctgtaaacaa taaggagaaa gccaggtgga tagatgaaac ctacaggagg gcccttcaac     3180

aggcctaata gaagggtcac ttccaaactg gcacgagcag ttaacagtgt cccttaaatc     3240

tttctctgga aggaaggaaa gatcaattac attcacaagt tcacacttct gcctgtgctc     3300

ctcaagggca gctgttgagg cctggaattc ctcactggtc agagaggtgt gtactgattg     3360

tctatggccc gcaggtggct ccgggaggat gagtccattt cgtagtccga gtcccgggct     3420

cgattcacag gctcatgctc caggtgctgc aggctgttgg ccagttcttc gggcgaaggc     3480

accaggtgga agatctgctc ggggggtgag gatcgccctg ggagaccctc tgggctgagc     3540

ccccggggac agccagaaga actaaggtgg ggaaggccca actctgaacc ccagtgagga     3600

agggactctg aatcccagtg aggaagggag aaagggaaga ggaccgtgtt gcaggaacct     3660

ggtggttggg agacgactac cacgtagctg gagagccgga catcacaggc ggcgccgcac     3720

tcgagtggga tgggcgagcg ctggaagtgg tggagcatgt ccacgaccga gggaaagtgg     3780

aggtgctgca cacggcactg gccccgctct gtcagcgaca ggcgcaggtg cttggctatc     3840

ccctgaaagt tgaaagtgag cacgtattcc ccacgccgcg tctcgctctg ccgcaccagg     3900

aacactccat gagcatcagg gccctgcagc tgaaccagct gagctgcttt cactctggag     3960

atggggccgt ggaaccaggg gtagcaggac aggaaatggt ccgtcttctg gcaggccggg     4020

tccagcagcc ccccaggaga agcaccttgg ttaagggaat ctgtgctgcc ccttggggag     4080

ctggacgtgc taggctctag ggctgaggga atatgcatct ctgcttctgt gctctccagc     4140

cctcggcctg tgcactccga gagctcagcc atccatgaat tcagctgctg ctcgtctccc     4200

acctcaaaga tgatgtctgt ccggtccttc accttcagca caaaggtgta aaggttgtca     4260

ggcatctcaa gccgtgtgca ccaccggacc tcctggatgc tggagcaagc tgcttgtagc     4320

ttgggccttg aactcttggg tgggtcgaag agctccagca cgcggtcggg gccatcgggg     4380

cccggggccc ggcgcagcgc cagcctcccg cgctgccagc gtgccccgct gtccatggag     4440

gcctcgtcgg ccaggctgta gcgcagcacc gcctccttca gcgcctcggg tggcggctcc     4500

cgggccaggc tccagggcag gaacttcttg gccaggccag gccgggcggg ggtctcagca     4560

gcctctccgg gggtcccggg ggcggcagcg gtgtgggccg ctggcagctc cccggccgag     4620

cggcggcgga agatgtggcg gaggctgcgg cgaaagtgct ggaaggagca gggcccgggc     4680

ggccgcggcg gggccagctc ctcagagctg cgggccttgg gcaggccagg ggcggcgggg     4740

ccggggcctg gctccgggga cgcctcggcc ttggctgggg gcccacggcc tgtgtcccgg     4800

tagtcgcggc ccggcgcccg tccgtcgcgc acctcgcggc agaagtagcg ctggaagagg     4860

tcggtgaact gcagcgacac cagctcggcg cgcagcggcg cgtgctgcgg atgctcccgg     4920

gcgaacagcc agtactggcg ggccagctcc cgggccgccg ctacggcgtg caactcacag     4980

aactcgctcc agccccgcgg ggccgccgcc ggggaggctg agggcgcgga agagggcgag     5040

gagggctgca gggcaggccc gttcatggcg gagacccagg tggtgcggcc gggctgagag     5100

acaggagctc tgggcccggc cggcccatgg cgtcgcgcgc ccccgggccc tcgaaatccc     5160

gagggggcgg gcgggccccc gccctgggcg cgtcctctcc cgcccgccgg ctcctcgctc     5220

gcggctcgct cgagcggggc tcaggcagga aacccgggct cggaaaatgg ccagcgcctc     5280

atcatttccg ccgccagcgc ttgacagttg cgggaggatg cgcccccggg ccgccgccgc     5340

cggggaaact ttgcagcggc cgccgtcgcc accgcgggcc gcgacagtcc gggcgggcag     5400

ccgggcggag gcggtggccc ggg                                             5423


<210>  3
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asn Gly Pro Ala Leu Gln Pro Ser Ser Pro Ser Ser Ala Pro Ser 
1               5                   10                  15      


Ala Ser Pro Ala Ala Ala Pro Arg Gly Trp Ser Glu Phe Cys Glu Leu 
            20                  25                  30          


His Ala Val Ala Ala Ala Arg Glu Leu Ala Arg Gln Tyr Trp Leu Phe 
        35                  40                  45              


Ala Arg Glu His Pro Gln His Ala Pro Leu Arg Ala Glu Leu Val Ser 
    50                  55                  60                  


Leu Gln Phe Thr Asp Leu Phe Gln Arg Tyr Phe Cys Arg Glu Val Arg 
65                  70                  75                  80  


Asp Gly Arg Ala Pro Gly Arg Asp Tyr Arg Asp Thr Gly Arg Gly Pro 
                85                  90                  95      


Pro Ala Lys Ala Glu Ala Ser Pro Glu Pro Gly Pro Gly Pro Ala Ala 
            100                 105                 110         


Pro Gly Leu Pro Lys Ala Arg Ser Ser Glu Glu Leu Ala Pro Pro Arg 
        115                 120                 125             


Pro Pro Gly Pro Cys Ser Phe Gln His Phe Arg Arg Ser Leu Arg His 
    130                 135                 140                 


Ile Phe Arg Arg Arg Ser Ala Gly Glu Leu Pro Ala Ala His Thr Ala 
145                 150                 155                 160 


Ala Ala Pro Gly Thr Pro Gly Glu Ala Ala Glu Thr Pro Ala Arg Pro 
                165                 170                 175     


Gly Leu Ala Lys Lys Phe Leu Pro Trp Ser Leu Ala Arg Glu Pro Pro 
            180                 185                 190         


Pro Glu Ala Leu Lys Glu Ala Val Leu Arg Tyr Ser Leu Ala Asp Glu 
        195                 200                 205             


Ala Ser Met Asp Ser Gly Ala Arg Trp Gln Arg Gly Arg Leu Ala Leu 
    210                 215                 220                 


Arg Arg Ala Pro Gly Pro Asp Gly Pro Asp Arg Val Leu Glu Leu Phe 
225                 230                 235                 240 


Asp Pro Pro Lys Ser Ser Arg Pro Lys Leu Gln Ala Ala Cys Ser Ser 
                245                 250                 255     


Ile Gln Glu Val Arg Trp Cys Thr Arg Leu Glu Met Pro Asp Asn Leu 
            260                 265                 270         


Tyr Thr Phe Val Leu Lys Val Lys Asp Arg Thr Asp Ile Ile Phe Glu 
        275                 280                 285             


Val Gly Asp Glu Gln Gln Leu Asn Ser Trp Met Ala Glu Leu Ser Glu 
    290                 295                 300                 


Cys Thr Gly Arg Gly Leu Glu Ser Thr Glu Ala Glu Met His Ile Pro 
305                 310                 315                 320 


Ser Ala Leu Glu Pro Ser Thr Ser Ser Ser Pro Arg Gly Ser Thr Asp 
                325                 330                 335     


Ser Leu Asn Gln Gly Ala Ser Pro Gly Gly Leu Leu Asp Pro Ala Cys 
            340                 345                 350         


Gln Lys Thr Asp His Phe Leu Ser Cys Tyr Pro Trp Phe His Gly Pro 
        355                 360                 365             


Ile Ser Arg Val Lys Ala Ala Gln Leu Val Gln Leu Gln Gly Pro Asp 
    370                 375                 380                 


Ala His Gly Val Phe Leu Val Arg Gln Ser Glu Thr Arg Arg Gly Glu 
385                 390                 395                 400 


Tyr Val Leu Thr Phe Asn Phe Gln Gly Ile Ala Lys His Leu Arg Leu 
                405                 410                 415     


Ser Leu Thr Glu Arg Gly Gln Cys Arg Val Gln His Leu His Phe Pro 
            420                 425                 430         


Ser Val Val Asp Met Leu His His Phe Gln Arg Ser Pro Ile Pro Leu 
        435                 440                 445             


Glu Cys Gly Ala Ala Cys Asp Val Arg Leu Ser Ser Tyr Val Val Val 
    450                 455                 460                 


Val Ser Gln Pro Pro Gly Ser Cys Asn Thr Val Leu Phe Pro Phe Ser 
465                 470                 475                 480 


Leu Pro His Trp Asp Ser Glu Ser Leu Pro His Trp Gly Ser Glu Leu 
                485                 490                 495     


Gly Leu Pro His Leu Ser Ser Ser Gly Cys Pro Arg Gly Leu Ser Pro 
            500                 505                 510         


Glu Gly Leu Pro Gly Arg Ser Ser Pro Pro Glu Gln Ile Phe His Leu 
        515                 520                 525             


Val Pro Ser Pro Glu Glu Leu Ala Asn Ser Leu Gln His Leu Glu His 
    530                 535                 540                 


Glu Pro Val Asn Arg Ala Arg Asp Ser Asp Tyr Glu Met Asp Ser Ser 
545                 550                 555                 560 


Ser Arg Ser His Leu Arg Ala Ile Asp Asn Gln Tyr Thr Pro Leu 
                565                 570                 575 


<210>  4
<211>  1888
<212>  DNA
<213>  Mus musculus

<400>  4
ggcacgagat cccattacag atggttgtga gccaccatgt ggttgctggg atttgaactc       60

aggacctctg gaagagcagt cagtactctt aaccacagag ccgttggagt ggctggcatg      120

tgacctgaaa ctggagtgcc agactgcctt gccctgttgc caagcccggc cgccccgcct      180

cgctctccac catgaacgag cccaccgtgc agccgtcccg cacatcctcc gcacccgcct      240

cgccggcatc cccacgcggc tggagcgact tctgcgagca gcacgcagca gcggcggccc      300

gggagctggc ccgccagtac tggttgtttg cgcgcgcgca cccacagccg ccgcgcgcgg      360

acctggtgtc gctgcagttc gcggagctct tccagcgcca cttctgccgg gaggtgcgcg      420

agagcctcgc aggaccgccg ggtcacgact accgcgccac tgctccgccc cgccccgcgc      480

tgcccaaggc acgcagctcc gaggacctgg gcccgcggcc cgcctgtgcc ctgcagcacc      540

tgcgccgcgg cctgcgccag ctcttccgcc gccgctcggc aggggagctg cccggggcta      600

ccagtgacac caatgacatc gacaccaccg cagccagcag gccgggcccg gcccgcaagt      660

tgctaccctg gggcctgcga gagccgccca ctgaggcgct caaggaggtc gtattgcgct      720

atagcctggc ggacgaggca gcaatggaca gcggcgcacg ctggcagcgg ggtcgcctgg      780

tgcttcggtc tccaggtccg ggccacagcc actttctgca gctcttcgat ccgcccaaga      840

gctcaaagcc caagctccaa gaggcctgtt ccagcatccg ggaggtccga ccatgtacac      900

gcctggagat gcctgacaac ctctacacct ttgtgttgaa ggtgcaggac cagacagaca      960

tcatctttga ggtgggagat gaacagcagc tgaactcatg gctggcagag ctcagggcaa     1020

gcacaggcct tgggctggag cacccggaca ccgagttacc tctttcctta gcggcagagc     1080

ctggcccagc tagatcccca aggggaagca ctgactccct ggaccaaggt gcttcacctg     1140

gggtgttgct ggacccagcc tgccagaaaa cagatcactt cctatcctgc tacccctggt     1200

tccacggccc catctccagg gtgagggctg cacagctggt ccagctccag ggccctgatg     1260

cccacggcgt gttcctggtg cggcagagtg agtcccggag aggagagtat gtactcacat     1320

tcaacttaca gggcagagcc aagcacttac gcctggtgct cacagagcgt ggacagtgcc     1380

gggtgcaaca cctgcacttc ccctcggtgg tagatatgct ccgccacttc cagcgttctc     1440

ctatcccact ggaatgtgga gcagcttgtg acgtccgact ctctggctat gtggtagtcc     1500

tctctcaggc accaggttcc tccaacaccg tcctcttccc tttttccctt cctcactggg     1560

attcggagct gggtcatccc cacctcagct ctgttggctg tccccccagc catggtgcag     1620

aggctctccc tggccaagtg acaccacctg agcagatctt ccacctggtg ccttctcctg     1680

aggaactggc caacagtctg cggcagctgg agctcgagtc tgtgagcagt gcccgggact     1740

cggactatga catggactcc tcttcacggg gccaccttcg ggccattgac aaccagtaca     1800

cccctctctc acagctgtgc agagaggcag acgtgtgaat ggaaccattt tcctcccctc     1860

cagagaacta taggctgctg tcagcctc                                        1888


<210>  5
<211>  1888
<212>  DNA
<213>  Mus musculus

<400>  5
gaggctgaca gcagcctata gttctctgga ggggaggaaa atggttccat tcacacgtct       60

gcctctctgc acagctgtga gagaggggtg tactggttgt caatggcccg aaggtggccc      120

cgtgaagagg agtccatgtc atagtccgag tcccgggcac tgctcacaga ctcgagctcc      180

agctgccgca gactgttggc cagttcctca ggagaaggca ccaggtggaa gatctgctca      240

ggtggtgtca cttggccagg gagagcctct gcaccatggc tggggggaca gccaacagag      300

ctgaggtggg gatgacccag ctccgaatcc cagtgaggaa gggaaaaagg gaagaggacg      360

gtgttggagg aacctggtgc ctgagagagg actaccacat agccagagag tcggacgtca      420

caagctgctc cacattccag tgggatagga gaacgctgga agtggcggag catatctacc      480

accgagggga agtgcaggtg ttgcacccgg cactgtccac gctctgtgag caccaggcgt      540

aagtgcttgg ctctgccctg taagttgaat gtgagtacat actctcctct ccgggactca      600

ctctgccgca ccaggaacac gccgtgggca tcagggccct ggagctggac cagctgtgca      660

gccctcaccc tggagatggg gccgtggaac caggggtagc aggataggaa gtgatctgtt      720

ttctggcagg ctgggtccag caacacccca ggtgaagcac cttggtccag ggagtcagtg      780

cttccccttg gggatctagc tgggccaggc tctgccgcta aggaaagagg taactcggtg      840

tccgggtgct ccagcccaag gcctgtgctt gccctgagct ctgccagcca tgagttcagc      900

tgctgttcat ctcccacctc aaagatgatg tctgtctggt cctgcacctt caacacaaag      960

gtgtagaggt tgtcaggcat ctccaggcgt gtacatggtc ggacctcccg gatgctggaa     1020

caggcctctt ggagcttggg ctttgagctc ttgggcggat cgaagagctg cagaaagtgg     1080

ctgtggcccg gacctggaga ccgaagcacc aggcgacccc gctgccagcg tgcgccgctg     1140

tccattgctg cctcgtccgc caggctatag cgcaatacga cctccttgag cgcctcagtg     1200

ggcggctctc gcaggcccca gggtagcaac ttgcgggccg ggcccggcct gctggctgcg     1260

gtggtgtcga tgtcattggt gtcactggta gccccgggca gctcccctgc cgagcggcgg     1320

cggaagagct ggcgcaggcc gcggcgcagg tgctgcaggg cacaggcggg ccgcgggccc     1380

aggtcctcgg agctgcgtgc cttgggcagc gcggggcggg gcggagcagt ggcgcggtag     1440

tcgtgacccg gcggtcctgc gaggctctcg cgcacctccc ggcagaagtg gcgctggaag     1500

agctccgcga actgcagcga caccaggtcc gcgcgcggcg gctgtgggtg cgcgcgcgca     1560

aacaaccagt actggcgggc cagctcccgg gccgccgctg ctgcgtgctg ctcgcagaag     1620

tcgctccagc cgcgtgggga tgccggcgag gcgggtgcgg aggatgtgcg ggacggctgc     1680

acggtgggct cgttcatggt ggagagcgag gcggggcggc cgggcttggc aacagggcaa     1740

ggcagtctgg cactccagtt tcaggtcaca tgccagccac tccaacggct ctgtggttaa     1800

gagtactgac tgctcttcca gaggtcctga gttcaaatcc cagcaaccac atggtggctc     1860

acaaccatct gtaatgggat ctcgtgcc                                        1888


<210>  6
<211>  548
<212>  PRT
<213>  Mus musculus

<400>  6

Met Asn Glu Pro Thr Val Gln Pro Ser Arg Thr Ser Ser Ala Pro Ala 
1               5                   10                  15      


Ser Pro Ala Ser Pro Arg Gly Trp Ser Asp Phe Cys Glu Gln His Ala 
            20                  25                  30          


Ala Ala Ala Ala Arg Glu Leu Ala Arg Gln Tyr Trp Leu Phe Ala Arg 
        35                  40                  45              


Ala His Pro Gln Pro Pro Arg Ala Asp Leu Val Ser Leu Gln Phe Ala 
    50                  55                  60                  


Glu Leu Phe Gln Arg His Phe Cys Arg Glu Val Arg Glu Ser Leu Ala 
65                  70                  75                  80  


Gly Pro Pro Gly His Asp Tyr Arg Ala Thr Ala Pro Pro Arg Pro Ala 
                85                  90                  95      


Leu Pro Lys Ala Arg Ser Ser Glu Asp Leu Gly Pro Arg Pro Ala Cys 
            100                 105                 110         


Ala Leu Gln His Leu Arg Arg Gly Leu Arg Gln Leu Phe Arg Arg Arg 
        115                 120                 125             


Ser Ala Gly Glu Leu Pro Gly Ala Thr Ser Asp Thr Asn Asp Ile Asp 
    130                 135                 140                 


Thr Thr Ala Ala Ser Arg Pro Gly Pro Ala Arg Lys Leu Leu Pro Trp 
145                 150                 155                 160 


Gly Leu Arg Glu Pro Pro Thr Glu Ala Leu Lys Glu Val Val Leu Arg 
                165                 170                 175     


Tyr Ser Leu Ala Asp Glu Ala Ala Met Asp Ser Gly Ala Arg Trp Gln 
            180                 185                 190         


Arg Gly Arg Leu Val Leu Arg Ser Pro Gly Pro Gly His Ser His Phe 
        195                 200                 205             


Leu Gln Leu Phe Asp Pro Pro Lys Ser Ser Lys Pro Lys Leu Gln Glu 
    210                 215                 220                 


Ala Cys Ser Ser Ile Arg Glu Val Arg Pro Cys Thr Arg Leu Glu Met 
225                 230                 235                 240 


Pro Asp Asn Leu Tyr Thr Phe Val Leu Lys Val Gln Asp Gln Thr Asp 
                245                 250                 255     


Ile Ile Phe Glu Val Gly Asp Glu Gln Gln Leu Asn Ser Trp Leu Ala 
            260                 265                 270         


Glu Leu Arg Ala Ser Thr Gly Leu Gly Leu Glu His Pro Asp Thr Glu 
        275                 280                 285             


Leu Pro Leu Ser Leu Ala Ala Glu Pro Gly Pro Ala Arg Ser Pro Arg 
    290                 295                 300                 


Gly Ser Thr Asp Ser Leu Asp Gln Gly Ala Ser Pro Gly Val Leu Leu 
305                 310                 315                 320 


Asp Pro Ala Cys Gln Lys Thr Asp His Phe Leu Ser Cys Tyr Pro Trp 
                325                 330                 335     


Phe His Gly Pro Ile Ser Arg Val Arg Ala Ala Gln Leu Val Gln Leu 
            340                 345                 350         


Gln Gly Pro Asp Ala His Gly Val Phe Leu Val Arg Gln Ser Glu Ser 
        355                 360                 365             


Arg Arg Gly Glu Tyr Val Leu Thr Phe Asn Leu Gln Gly Arg Ala Lys 
    370                 375                 380                 


His Leu Arg Leu Val Leu Thr Glu Arg Gly Gln Cys Arg Val Gln His 
385                 390                 395                 400 


Leu His Phe Pro Ser Val Val Asp Met Leu Arg His Phe Gln Arg Ser 
                405                 410                 415     


Pro Ile Pro Leu Glu Cys Gly Ala Ala Cys Asp Val Arg Leu Ser Gly 
            420                 425                 430         


Tyr Val Val Val Leu Ser Gln Ala Pro Gly Ser Ser Asn Thr Val Leu 
        435                 440                 445             


Phe Pro Phe Ser Leu Pro His Trp Asp Ser Glu Leu Gly His Pro His 
    450                 455                 460                 


Leu Ser Ser Val Gly Cys Pro Pro Ser His Gly Ala Glu Ala Leu Pro 
465                 470                 475                 480 


Gly Gln Val Thr Pro Pro Glu Gln Ile Phe His Leu Val Pro Ser Pro 
                485                 490                 495     


Glu Glu Leu Ala Asn Ser Leu Arg Gln Leu Glu Leu Glu Ser Val Ser 
            500                 505                 510         


Ser Ala Arg Asp Ser Asp Tyr Asp Met Asp Ser Ser Ser Arg Gly His 
        515                 520                 525             


Leu Arg Ala Ile Asp Asn Gln Tyr Thr Pro Leu Ser Gln Leu Cys Arg 
    530                 535                 540                 


Glu Ala Asp Val 
545             


<210>  7
<211>  29
<212>  DNA
<213>  Mus musculus

<400>  7
aaggatccat gcctgacaac ctctacacc                                         29


<210>  8
<211>  29
<212>  DNA
<213>  Mus musculus

<400>  8
atggatccta ggggtagcag gataggaag                                         29


<210>  9
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  9
ttggatccgt cctctctcag gcaccag                                           27


<210>  10
<211>  26
<212>  DNA
<213>  Mus musculus

<400>  10
taggatccat tcacacgtct gcctct                                            26


<210>  11
<211>  3680
<212>  DNA
<213>  Rattus norvegicus

<400>  11
tcctagagct caaagcccaa gctccaagag gcctgctcca gcatccagga ggtccgaccc       60

tgcacacgcc tggagatgcc ggacaacctc tacacctttg tgttgaaggt gagcgccagg      120

gctgtggctc cttggggaga cactgctgtc tcctcaggtg cagagctata tgcctccttt      180

ctgcaggtgc agggccagac agacatcatc tttgaggtgg gagatgaaca gcagctgaac      240

tcatggctgg cagaactcag ggcaagcaca ggcctagggt gaggacctgc ccatccctgg      300

ttccctttga taacccctgc tggccccctt ctcaccagcc tcttccccta caggttggag      360

cacctggaca cagagttacc tctttcctta gtggcagagc ctggcccagc tatatcccca      420

aggggaagca cggactccct ggaccaaggt atgtgccaga tccttggtct ctgggtgtcc      480

ttggacatgt ggcccctctg cgggtcacca ccaccatctt tctgccaggt gcttcacctg      540

gggtgatgtt ggacccagcc tgccagaaaa cagatcactt cctgtcctgc tacccctggt      600

tccacggccc catctccagg gtgagggctg cacagctggt tcagctgcag ggccctgatg      660

cccacggtgt gttcctggtg cggcagagtg agtcccggag aggggaatat gtactcacat      720

tcaacttaca ggggagagcc aagcacctcc gcctggtgct cacagagcgt ggacagtgcc      780

gggtgcaaca cctgcacttc ccctcggtgg tggatatgct ccgccacttc cagcgctccc      840

ccatcccact tgaatgtgga gcagcctgtg atgtccgact ctctggctat gtggtagtcg      900

tctctcaggc accaggtagg aagcccaaag ttgtgtcaag gggtggtgtc acagcaagta      960

cagcacgtac aaaacttcct tcctggttac gccttcttca tggagtcatc catgttatct     1020

ctccaggttc ctccaacacc gttctcttcc ccttttccct tcctcactgg gactcagagc     1080

tgggccatcc ccacctcagc tctgctggct gtccccctgg ccatggtgca gaggctctcc     1140

gtggccaagt gacacctcct gagcagatct tccacctggt gccttctcct gaggaactgg     1200

ccaacagtct gcggcagctg gagcttgagt ctgtgagcag tgcccgggac tcagactatg     1260

aaatggactc ctcctcacgg agccaccttc gggccattga caaccagtac acccctctct     1320

cacagctgtg cagagaggca aacttgtgaa tgtaaccatt ttccttccct ccagagaact     1380

acaggctgct gctgtcagcc ttccccagct cagatgtgcc tgcttccacc acacacaagg     1440

ctgtcacagg cttctgtcag ccacagctag cctggcttct tcccactgtc tgtagatgta     1500

gttcttgtgc acaggtgcca ctagctggca ccaaggcctc gttcccaacc cagaggaggc     1560

ggggctgcag gcccagagct ggcagtggaa actgacagag ctgatgacag acttcttacc     1620

aggtagggtc atcgggaagc acaaaacact aacagtccct ggattctcac atggtgtcct     1680

tccctgtagc ttcattctgt ggcaagtcta agtcccatgt cacaggcgta ggacacttca     1740

taatcctgct tctactctta gctttggaca gaagctctgc cagaggggca agcttaaaga     1800

tcaaaaatga tttaaacatt ttacctcaga gtaattattt ttaaagggtt caggtttcca     1860

cttgatatta tagcttactt cactgcactg ccctgctacc ccctgccact gtaaagttgg     1920

ggggagctga gtccccctgc tttgcttacc ttgagccagg ctagcatgct agtgtccttg     1980

tctgctcacc ctcaggacag ttgcctgcta cggggtagac actgtcctcc ctaatgtaga     2040

gaatgaagtg tgtcaccctc tcagggaaat ccaggcagct tgcagagaga ggagggtggc     2100

aggggacatt ccaccccagt gccttatgca ttaaaaacaa aatcaggact gtggtttaca     2160

gcagcgttag aggatgagat gaatgggtgg gggaagacaa acacagatgg aaggcctcta     2220

ggcttcttta gtgaacccac attttactcc ccccaacccc ctcccagcat ctaggggctt     2280

agtgagtttg gcccatgcta tgaagaaact cctgtaaccg ctcctaggtg ttcttatcca     2340

tacaatcttt ccatctagac agagccaaaa actgtcatct ttcctaaggg atgcagttca     2400

cagggactgg agcaggctgt tcatggcaca aacagtgctt acagcagtgg ctttgggaaa     2460

ccacaactta attccttgaa cattgagagg cagccatgct gctgccctgc tgcagacagc     2520

agtgctgact ccccctctgc tcaccttgca ctcgggaagc ctgcgtgggc tttggtgatg     2580

gaagcagctg cacctcagct tcgacaccca ccacaggtgt ggacctgtgc tcatcttagg     2640

acagcgcctt ccttcactgc acatcaggta tgaaccagag acgtgagcag taacagccag     2700

tgggccaggc cggctctaat ccacacagga tgcgtggacg gctgtgccct gcacctggcc     2760

aggagctaaa cccacttcaa acttggggca ctcatttctc ctgggccttc aaagagagac     2820

ttgctaggtg ctgtaagcca gcaccttggc cccttagtgc tgggattcac tcactgtgga     2880

cagctttgtt tcaaaaaatg tccaagatat cagaaaacaa ggtaaaaaag tctcatgact     2940

ctgtgacaga gtgacaacac taagccagca ccttttcttt aagctaaagt aggtcagttg     3000

gctgacgggg acagacgggt accgggtatg agaactcctg ggccagatac cctgtgtcaa     3060

agccaggccc cactcccacc ctcagcagtg tcttctggcc acacaaggca ggatgggtca     3120

gtggccacta gagacagagc agctcaacag tcctgaaccc ctgctccctt ctcccgagta     3180

ctcaactcag actaacaagc accagcacca aagagttagg tcaactaacc tgccttgtct     3240

ttaccagcat ccacatggct ttatctgtat aaatcttctg cctttgatca tttctggatg     3300

gtgtaggaaa aaaggaatag tgaccattac agtcttgggc cagacaacac tatttttacc     3360

taagtctctt aacctaaatt acgtcgcctc ttcctgaggc tcagtctctt gtttaaatgt     3420

taccttggtg caaataaaag tgataaactg tcccccactg cctcctgacg agacacatct     3480

gtctaatggc cagcgtgtgg ctggaataag cagcattgtg accacaggat caggggactt     3540

catcttctat cattagagca gaaggtattt ggcaaatctt tgttttatgt actgtacgag     3600

taacttattc ttgaataatg caaattttcc tacaatgtac aaattgctgt atgtgaatta     3660

aaaaggtttt cagaattaca                                                 3680


<210>  12
<211>  3680
<212>  DNA
<213>  Rattus norvegicus

<400>  12
tgtaattctg aaaacctttt taattcacat acagcaattt gtacattgta ggaaaatttg       60

cattattcaa gaataagtta ctcgtacagt acataaaaca aagatttgcc aaataccttc      120

tgctctaatg atagaagatg aagtcccctg atcctgtggt cacaatgctg cttattccag      180

ccacacgctg gccattagac agatgtgtct cgtcaggagg cagtggggga cagtttatca      240

cttttatttg caccaaggta acatttaaac aagagactga gcctcaggaa gaggcgacgt      300

aatttaggtt aagagactta ggtaaaaata gtgttgtctg gcccaagact gtaatggtca      360

ctattccttt tttcctacac catccagaaa tgatcaaagg cagaagattt atacagataa      420

agccatgtgg atgctggtaa agacaaggca ggttagttga cctaactctt tggtgctggt      480

gcttgttagt ctgagttgag tactcgggag aagggagcag gggttcagga ctgttgagct      540

gctctgtctc tagtggccac tgacccatcc tgccttgtgt ggccagaaga cactgctgag      600

ggtgggagtg gggcctggct ttgacacagg gtatctggcc caggagttct catacccggt      660

acccgtctgt ccccgtcagc caactgacct actttagctt aaagaaaagg tgctggctta      720

gtgttgtcac tctgtcacag agtcatgaga cttttttacc ttgttttctg atatcttgga      780

cattttttga aacaaagctg tccacagtga gtgaatccca gcactaaggg gccaaggtgc      840

tggcttacag cacctagcaa gtctctcttt gaaggcccag gagaaatgag tgccccaagt      900

ttgaagtggg tttagctcct ggccaggtgc agggcacagc cgtccacgca tcctgtgtgg      960

attagagccg gcctggccca ctggctgtta ctgctcacgt ctctggttca tacctgatgt     1020

gcagtgaagg aaggcgctgt cctaagatga gcacaggtcc acacctgtgg tgggtgtcga     1080

agctgaggtg cagctgcttc catcaccaaa gcccacgcag gcttcccgag tgcaaggtga     1140

gcagaggggg agtcagcact gctgtctgca gcagggcagc agcatggctg cctctcaatg     1200

ttcaaggaat taagttgtgg tttcccaaag ccactgctgt aagcactgtt tgtgccatga     1260

acagcctgct ccagtccctg tgaactgcat cccttaggaa agatgacagt ttttggctct     1320

gtctagatgg aaagattgta tggataagaa cacctaggag cggttacagg agtttcttca     1380

tagcatgggc caaactcact aagcccctag atgctgggag ggggttgggg ggagtaaaat     1440

gtgggttcac taaagaagcc tagaggcctt ccatctgtgt ttgtcttccc ccacccattc     1500

atctcatcct ctaacgctgc tgtaaaccac agtcctgatt ttgtttttaa tgcataaggc     1560

actggggtgg aatgtcccct gccaccctcc tctctctgca agctgcctgg atttccctga     1620

gagggtgaca cacttcattc tctacattag ggaggacagt gtctaccccg tagcaggcaa     1680

ctgtcctgag ggtgagcaga caaggacact agcatgctag cctggctcaa ggtaagcaaa     1740

gcagggggac tcagctcccc ccaactttac agtggcaggg ggtagcaggg cagtgcagtg     1800

aagtaagcta taatatcaag tggaaacctg aaccctttaa aaataattac tctgaggtaa     1860

aatgtttaaa tcatttttga tctttaagct tgcccctctg gcagagcttc tgtccaaagc     1920

taagagtaga agcaggatta tgaagtgtcc tacgcctgtg acatgggact tagacttgcc     1980

acagaatgaa gctacaggga aggacaccat gtgagaatcc agggactgtt agtgttttgt     2040

gcttcccgat gaccctacct ggtaagaagt ctgtcatcag ctctgtcagt ttccactgcc     2100

agctctgggc ctgcagcccc gcctcctctg ggttgggaac gaggccttgg tgccagctag     2160

tggcacctgt gcacaagaac tacatctaca gacagtggga agaagccagg ctagctgtgg     2220

ctgacagaag cctgtgacag ccttgtgtgt ggtggaagca ggcacatctg agctggggaa     2280

ggctgacagc agcagcctgt agttctctgg agggaaggaa aatggttaca ttcacaagtt     2340

tgcctctctg cacagctgtg agagaggggt gtactggttg tcaatggccc gaaggtggct     2400

ccgtgaggag gagtccattt catagtctga gtcccgggca ctgctcacag actcaagctc     2460

cagctgccgc agactgttgg ccagttcctc aggagaaggc accaggtgga agatctgctc     2520

aggaggtgtc acttggccac ggagagcctc tgcaccatgg ccagggggac agccagcaga     2580

gctgaggtgg ggatggccca gctctgagtc ccagtgagga agggaaaagg ggaagagaac     2640

ggtgttggag gaacctggag agataacatg gatgactcca tgaagaaggc gtaaccagga     2700

aggaagtttt gtacgtgctg tacttgctgt gacaccaccc cttgacacaa ctttgggctt     2760

cctacctggt gcctgagaga cgactaccac atagccagag agtcggacat cacaggctgc     2820

tccacattca agtgggatgg gggagcgctg gaagtggcgg agcatatcca ccaccgaggg     2880

gaagtgcagg tgttgcaccc ggcactgtcc acgctctgtg agcaccaggc ggaggtgctt     2940

ggctctcccc tgtaagttga atgtgagtac atattcccct ctccgggact cactctgccg     3000

caccaggaac acaccgtggg catcagggcc ctgcagctga accagctgtg cagccctcac     3060

cctggagatg gggccgtgga accaggggta gcaggacagg aagtgatctg ttttctggca     3120

ggctgggtcc aacatcaccc caggtgaagc acctggcaga aagatggtgg tggtgacccg     3180

cagaggggcc acatgtccaa ggacacccag agaccaagga tctggcacat accttggtcc     3240

agggagtccg tgcttcccct tggggatata gctgggccag gctctgccac taaggaaaga     3300

ggtaactctg tgtccaggtg ctccaacctg taggggaaga ggctggtgag aagggggcca     3360

gcaggggtta tcaaagggaa ccagggatgg gcaggtcctc accctaggcc tgtgcttgcc     3420

ctgagttctg ccagccatga gttcagctgc tgttcatctc ccacctcaaa gatgatgtct     3480

gtctggccct gcacctgcag aaaggaggca tatagctctg cacctgagga gacagcagtg     3540

tctccccaag gagccacagc cctggcgctc accttcaaca caaaggtgta gaggttgtcc     3600

ggcatctcca ggcgtgtgca gggtcggacc tcctggatgc tggagcaggc ctcttggagc     3660

ttgggctttg agctctagga                                                 3680


<210>  13
<211>  368
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Ala Gly Arg Thr Gln Gly Lys His Arg Pro Arg Val Arg Thr Cys 
1               5                   10                  15      


Pro Ser Leu Val Pro Phe Asp Asn Pro Cys Trp Pro Pro Ser His Gln 
            20                  25                  30          


Pro Leu Pro Leu Gln Val Gly Ala Pro Gly His Arg Val Thr Ser Phe 
        35                  40                  45              


Leu Ser Gly Arg Ala Trp Pro Ser Tyr Ile Pro Lys Gly Lys His Gly 
    50                  55                  60                  


Leu Pro Gly Pro Arg Tyr Val Pro Asp Pro Trp Ser Leu Gly Val Leu 
65                  70                  75                  80  


Gly His Val Ala Pro Leu Arg Val Thr Thr Thr Ile Phe Leu Pro Gly 
                85                  90                  95      


Ala Ser Pro Gly Val Met Leu Asp Pro Ala Cys Gln Lys Thr Asp His 
            100                 105                 110         


Phe Leu Ser Cys Tyr Pro Trp Phe His Gly Pro Ile Ser Arg Val Arg 
        115                 120                 125             


Ala Ala Gln Leu Val Gln Leu Gln Gly Pro Asp Ala His Gly Val Phe 
    130                 135                 140                 


Leu Val Arg Gln Ser Glu Ser Arg Arg Gly Glu Tyr Val Leu Thr Phe 
145                 150                 155                 160 


Asn Leu Gln Gly Arg Ala Lys His Leu Arg Leu Val Leu Thr Glu Arg 
                165                 170                 175     


Gly Gln Cys Arg Val Gln His Leu His Phe Pro Ser Val Val Asp Met 
            180                 185                 190         


Leu Arg His Phe Gln Arg Ser Pro Ile Pro Leu Glu Cys Gly Ala Ala 
        195                 200                 205             


Cys Asp Val Arg Leu Ser Gly Tyr Val Val Val Val Ser Gln Ala Pro 
    210                 215                 220                 


Gly Arg Lys Pro Lys Val Val Ser Arg Gly Gly Val Thr Ala Ser Thr 
225                 230                 235                 240 


Ala Arg Thr Lys Leu Pro Ser Trp Leu Arg Leu Leu His Gly Val Ile 
                245                 250                 255     


His Val Ile Ser Pro Gly Ser Ser Asn Thr Val Leu Phe Pro Phe Ser 
            260                 265                 270         


Leu Pro His Trp Asp Ser Glu Leu Gly His Pro His Leu Ser Ser Ala 
        275                 280                 285             


Gly Cys Pro Pro Gly His Gly Ala Glu Ala Leu Arg Gly Gln Val Thr 
    290                 295                 300                 


Pro Pro Glu Gln Ile Phe His Leu Val Pro Ser Pro Glu Glu Leu Ala 
305                 310                 315                 320 


Asn Ser Leu Arg Gln Leu Glu Leu Glu Ser Val Ser Ser Ala Arg Asp 
                325                 330                 335     


Ser Asp Tyr Glu Met Asp Ser Ser Ser Arg Ser His Leu Arg Ala Ile 
            340                 345                 350         


Asp Asn Gln Tyr Thr Pro Leu Ser Gln Leu Cys Arg Glu Ala Asn Leu 
        355                 360                 365             


