                         SEQUENCE LISTING

<110>  Yan, Shi Du
 
<120>  METHODS FOR TREATING AND PREVENTING MULTIPLE SCLEROSIS

<130>  COL001032PCT

<150>  60/915,127
<151>  2007-05-01

<160>  5     

<170>  PatentIn version 3.4

<210>  1
<211>  546
<212>  DNA
<213>  Homo sapiens

<400>  1
atggaagcca tgaatgttga gaaagcctca gcagatggga acttgccaga ggtgatctct     60

aacatcaagg agactctgaa gatagtgtcc aggacaccag ttaacatcac tatggcaggg    120

gactctggca atgggatgtc caccttcatc agtgcccttc gaaacacagg acatgagggt    180

aaggcctcac ctcctactga gctggtaaaa gctacccaaa gatgtgcctc ctatttctct    240

tcccactttt caaatgtggt gttgtgggac ctgcctggca cagggtctgc caccacaacc    300

ctggagaact acctgatgga aatgcagttc aaccggtatg acttcatcat ggttgcatct    360

gcacaattca gcatgaatca tgtgatgctt gccaaaaccg ctgaggacat gggaaagaag    420

ttctacattg tctggaccaa gctagacatg gacctcagca caggtgccct cccagaagtg    480

cagctactgc agatcagaga aaatgtcctg gaaaatctcc agaaggagcg ggtatgtgaa    540

tactaa                                                               546


<210>  2
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asn Val Glu Lys Ala Ser Ala Asp Gly Asn Leu Pro Glu Val Ile 
1               5                   10                  15      


Ser Asn Ile Lys Glu Thr Leu Lys Ile Val Ser Arg Thr Pro Val Asn 
            20                  25                  30          


Ile Thr Met Ala Gly Asp Ser Gly Asn Gly Met Ser Thr Phe Ile Ser 
        35                  40                  45              


Ala Leu Arg Asn Thr Gly His Glu Gly Lys Ala Ser Pro Pro Thr Glu 
    50                  55                  60                  


Leu Val Lys Ala Thr Gln Arg Cys Ala Ser Tyr Phe Ser Ser His Phe 
65                  70                  75                  80  


Ser Asn Val Val Leu Trp Asp Leu Pro Gly Thr Gly Ser Ala Thr Thr 
                85                  90                  95      


Thr Leu Glu Asn Tyr Leu Met Glu Met Gln Phe Asn Arg Tyr Asp Phe 
            100                 105                 110         


Ile Met Val Ala Ser Ala Gln Phe Ser Met Asn His Val Met Leu Ala 
        115                 120                 125             


Lys Thr Ala Glu Asp Met Gly Lys Lys Phe Tyr Ile Val Trp Thr Lys 
    130                 135                 140                 


Leu Asp Met Asp Leu Ser Thr Gly Ala Leu Pro Glu Val Gln Leu Leu 
145                 150                 155                 160 


Gln Ile Arg Glu Asn Val Leu Glu Asn Leu Gln Lys Glu Arg Val Cys 
                165                 170                 175     


Glu Tyr 
        


<210>  3
<211>  2227
<212>  DNA
<213>  Mus musculus

<400>  3
gcaaggtctg ctcgaagacc agaagctgaa agaaaatcca cgcgatcaga cctcctcttg     60

gttcgtctcc tctcagaagg actccagacc tctgcatctc atctctcaac atccgggtct    120

atattccagt tttggatctc tacataggga acttctgccg gaggacagca acgtttttgt    180

cctaggaaga aaggggtgac gttccaggaa ggccactaac atcgaatcac acataataac    240

tcctctggat cagggtttga ggagtattaa gtgagataag gcattcgaag gaaccaactc    300

agattcacag acagaggacc tgtgtgctta aagtctaaga gtggaggaag aacctgagga    360

gcggcttcct cagagaccct aataaaacca gagagcctca ccagggagct gaaaggtcca    420

cagacagcgt cactcggatc ttatcatgaa accatcacac agttcctgcg aggctgctcc    480

actactcccc aacatggcag agacccatta tgctcccctg agctcagcct tcccctttgt    540

cacgtcatac caaacaggct ccagcaggtt acctgaggtc agtaggagca ccgaaagagc    600

tttaagagaa ggaaaactac tggaactggt ctacggaatc aaggagactg tggcaacatt    660

gtcccagatt ccagtgagca tctttgtgac tggggactct ggcaatggca tgtcatcttt    720

catcaatgca cttcgagtca tcggccatga tgaagatgcc tcggctccca ctggggtggt    780

gaggaccacg aagacgcgga ctgagtactc ttcatcccac tttcccaatg tggtgctgtg    840

ggacttacct ggattggggg ccacagccca aaccgtagag gactatgtgg aagagatgaa    900

atttagcaca tgtgacttat tcatcatcat tgcctctgag cagttcagct cgaatcatgt    960

gaagctgtcc aaaattatcc agagcatggg aaagaggttc tatattgtct ggaccaagct   1020

ggacagggac ctcagcacca gtgtcctatc agaggtccgg ctcctacaga atatccagga   1080

gaatatccga gagaatctgc agaaggagaa agtgaagtac ccccccgtgt tcctggtatc   1140

cagtctagac cctttactat atgacttccc gaagcttagg gacacacttc ataaagatct   1200

ctccaacatc aggtgctgtg aacccttaaa gaccctttat ggcacttatg agaagatcgt   1260

tggtgataaa gtagcagtct ggaagcagag aatagccaac gagtccttga agaattctct   1320

cggtgtcaga gatgatgaca acatgggcga gtgtctgaaa gtgtaccgac tgatatttgg   1380

tgtagatgac gaatcagttc agcaggtagc ccagagtatg gggacagtag tcatggagta   1440

caaggacaac atgaagtccc aaaactttta tactctccgc agagaggact ggaaactgag   1500

gctgatgaca tgtgcaattg tgaatgcatt cttccgtttg ttgagatttc tcccatgcgt   1560

atgctgctgt ttaagacgct tgagacataa acgcatgctt ttcttagttg cccaggacac   1620

caagaacatc ctagagaaaa tcctgaggga ctccatcttc cctccgcaga tctagtataa   1680

gggcagcctg gtacccttct tcttccacag aagccaggtt accttagatc tctttcctag   1740

atccctattt ctccaccaga aatcaagaga tacaaaaatg cttcctgtaa gggttttaga   1800

ttctctgaga ggagttaaaa tcactcatct cccctgtctc gattctaatg cattgttcca   1860

ctgagggaca gggacaagta gtgattaaaa ttcattgacc atgattctta gatttggaat   1920

atagaaattt tgtttttggg ctggagagat ggcttagcag ttaagaacac caactgcttt   1980

tccgaaggtc atgagttcaa atcccagcaa ccacgtgatg gctcacaacc atccgtagtg   2040

agatctgatg ccctcttctg agatgtctga agacagctac agtgtactta catataataa   2100

ataaataaat aaataaataa ataaataaat ctttgggaaa aaaattagaa attttgtttt   2160

cagctattaa atgtgatata tgtccaaatc aattttcctc tgaaacaata aagtcggttc   2220

ctcttca                                                             2227


<210>  4
<211>  409
<212>  PRT
<213>  Mus musculus

<400>  4

Met Lys Pro Ser His Ser Ser Cys Glu Ala Ala Pro Leu Leu Pro Asn 
1               5                   10                  15      


Met Ala Glu Thr His Tyr Ala Pro Leu Ser Ser Ala Phe Pro Phe Val 
            20                  25                  30          


Thr Ser Tyr Gln Thr Gly Ser Ser Arg Leu Pro Glu Val Ser Arg Ser 
        35                  40                  45              


Thr Glu Arg Ala Leu Arg Glu Gly Lys Leu Leu Glu Leu Val Tyr Gly 
    50                  55                  60                  


Ile Lys Glu Thr Val Ala Thr Leu Ser Gln Ile Pro Val Ser Ile Phe 
65                  70                  75                  80  


Val Thr Gly Asp Ser Gly Asn Gly Met Ser Ser Phe Ile Asn Ala Leu 
                85                  90                  95      


Arg Val Ile Gly His Asp Glu Asp Ala Ser Ala Pro Thr Gly Val Val 
            100                 105                 110         


Arg Thr Thr Lys Thr Arg Thr Glu Tyr Ser Ser Ser His Phe Pro Asn 
        115                 120                 125             


Val Val Leu Trp Asp Leu Pro Gly Leu Gly Ala Thr Ala Gln Thr Val 
    130                 135                 140                 


Glu Asp Tyr Val Glu Glu Met Lys Phe Ser Thr Cys Asp Leu Phe Ile 
145                 150                 155                 160 


Ile Ile Ala Ser Glu Gln Phe Ser Ser Asn His Val Lys Leu Ser Lys 
                165                 170                 175     


Ile Ile Gln Ser Met Gly Lys Arg Phe Tyr Ile Val Trp Thr Lys Leu 
            180                 185                 190         


Asp Arg Asp Leu Ser Thr Ser Val Leu Ser Glu Val Arg Leu Leu Gln 
        195                 200                 205             


Asn Ile Gln Glu Asn Ile Arg Glu Asn Leu Gln Lys Glu Lys Val Lys 
    210                 215                 220                 


Tyr Pro Pro Val Phe Leu Val Ser Ser Leu Asp Pro Leu Leu Tyr Asp 
225                 230                 235                 240 


Phe Pro Lys Leu Arg Asp Thr Leu His Lys Asp Leu Ser Asn Ile Arg 
                245                 250                 255     


Cys Cys Glu Pro Leu Lys Thr Leu Tyr Gly Thr Tyr Glu Lys Ile Val 
            260                 265                 270         


Gly Asp Lys Val Ala Val Trp Lys Gln Arg Ile Ala Asn Glu Ser Leu 
        275                 280                 285             


Lys Asn Ser Leu Gly Val Arg Asp Asp Asp Asn Met Gly Glu Cys Leu 
    290                 295                 300                 


Lys Val Tyr Arg Leu Ile Phe Gly Val Asp Asp Glu Ser Val Gln Gln 
305                 310                 315                 320 


Val Ala Gln Ser Met Gly Thr Val Val Met Glu Tyr Lys Asp Asn Met 
                325                 330                 335     


Lys Ser Gln Asn Phe Tyr Thr Leu Arg Arg Glu Asp Trp Lys Leu Arg 
            340                 345                 350         


Leu Met Thr Cys Ala Ile Val Asn Ala Phe Phe Arg Leu Leu Arg Phe 
        355                 360                 365             


Leu Pro Cys Val Cys Cys Cys Leu Arg Arg Leu Arg His Lys Arg Met 
    370                 375                 380                 


Leu Phe Leu Val Ala Gln Asp Thr Lys Asn Ile Leu Glu Lys Ile Leu 
385                 390                 395                 400 


Arg Asp Ser Ile Phe Pro Pro Gln Ile 
                405                 


<210>  5
<211>  19
<212>  RNA
<213>  Artificial construct

<220>
<223>  Synthetic sequence

<400>  5
gguuaccuga ggucaguag                                                  19


