                         SEQUENCE LISTING

<110>  Sygehuset Glostrup
 
<120>  Prevention of intraocular fibrosis

<130>  P1588PC00

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg Ile Gln Asp 
1               5                   10                  15      


Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe Val Met Ile Pro 
            20                  25                  30          


Thr Leu Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly Asn Ser Leu 
        35                  40                  45              


Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Thr Val Ala Ser 
    50                  55                  60                  


Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe Leu Leu Thr 
65                  70                  75                  80  


Leu Pro Leu Trp Ala Val Tyr Thr Ala Met Glu Tyr Arg Trp Pro Phe 
                85                  90                  95      


Gly Asn Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser Phe Asn Leu 
            100                 105                 110         


Tyr Ala Ser Val Phe Leu Leu Thr Cys Leu Ser Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Thr Met Leu Val 
    130                 135                 140                 


Ala Lys Val Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly Leu Ala Ser 
145                 150                 155                 160 


Leu Pro Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu Asn Thr Asn 
                165                 170                 175     


Ile Thr Val Cys Ala Phe His Tyr Glu Ser Gln Asn Ser Thr Leu Pro 
            180                 185                 190         


Ile Gly Leu Gly Leu Thr Lys Asn Ile Leu Gly Phe Leu Phe Pro Phe 
        195                 200                 205             


Leu Ile Ile Leu Thr Ser Tyr Thr Leu Ile Trp Lys Ala Leu Lys Lys 
    210                 215                 220                 


Ala Tyr Glu Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp Ile Phe Lys 
225                 230                 235                 240 


Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp Ile Pro His 
                245                 250                 255     


Gln Ile Phe Thr Phe Leu Asp Val Leu Ile Gln Leu Gly Ile Ile Arg 
            260                 265                 270         


Asp Cys Arg Ile Ala Asp Ile Val Asp Thr Ala Met Pro Ile Thr Ile 
        275                 280                 285             


Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe Tyr Gly Phe 
    290                 295                 300                 


Leu Gly Lys Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu Lys Tyr Ile 
305                 310                 315                 320 


Pro Pro Lys Ala Lys Ser His Ser Asn Leu Ser Thr Lys Met Ser Thr 
                325                 330                 335     


Leu Ser Tyr Arg Pro Ser Asp Asn Val Ser Ser Ser Thr Lys Lys Pro 
            340                 345                 350         


Ala Pro Cys Phe Glu Val Glu 
        355                 


<210>  2
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Gly Asn Ser Thr Leu Ala Thr Thr Ser Lys Asn Ile Thr Ser 
1               5                   10                  15      


Gly Leu His Phe Gly Leu Val Asn Ile Ser Gly Asn Asn Glu Ser Thr 
            20                  25                  30          


Leu Asn Cys Ser Gln Lys Pro Ser Asp Lys His Leu Asp Ala Ile Pro 
        35                  40                  45              


Ile Leu Tyr Tyr Ile Ile Phe Val Ile Gly Phe Leu Val Asn Ile Val 
    50                  55                  60                  


Val Val Thr Leu Phe Cys Cys Gln Lys Gly Pro Lys Lys Val Ser Ser 
65                  70                  75                  80  


Ile Tyr Ile Phe Asn Leu Ala Val Ala Asp Leu Leu Leu Leu Ala Thr 
                85                  90                  95      


Leu Pro Leu Trp Ala Thr Tyr Tyr Ser Tyr Arg Tyr Asp Trp Leu Phe 
            100                 105                 110         


Gly Pro Val Met Cys Lys Val Phe Gly Ser Phe Leu Thr Leu Asn Met 
        115                 120                 125             


Phe Ala Ser Ile Phe Phe Ile Thr Cys Met Ser Val Asp Arg Tyr Gln 
    130                 135                 140                 


Ser Val Ile Tyr Pro Phe Leu Ser Gln Arg Arg Asn Pro Trp Gln Ala 
145                 150                 155                 160 


Ser Tyr Ile Val Pro Leu Val Trp Cys Met Ala Cys Leu Ser Ser Leu 
                165                 170                 175     


Pro Thr Phe Tyr Phe Arg Asp Val Arg Thr Ile Glu Tyr Leu Gly Val 
            180                 185                 190         


Asn Ala Cys Ile Met Ala Phe Pro Pro Glu Lys Tyr Ala Gln Trp Ser 
        195                 200                 205             


Ala Gly Ile Ala Leu Met Lys Asn Ile Leu Gly Phe Ile Ile Pro Leu 
    210                 215                 220                 


Ile Phe Ile Ala Thr Cys Tyr Phe Gly Ile Arg Lys His Leu Leu Lys 
225                 230                 235                 240 


Thr Asn Ser Tyr Gly Lys Asn Arg Ile Thr Arg Asp Gln Val Leu Lys 
                245                 250                 255     


Met Ala Ala Ala Val Val Leu Ala Phe Ile Ile Cys Trp Leu Pro Phe 
            260                 265                 270         


His Val Leu Thr Phe Leu Asp Ala Leu Ala Trp Met Gly Val Ile Asn 
        275                 280                 285             


Ser Cys Glu Val Ile Ala Val Ile Asp Leu Ala Leu Pro Phe Ala Ile 
    290                 295                 300                 


Leu Leu Gly Phe Thr Asn Ser Cys Val Asn Pro Phe Leu Tyr Cys Phe 
305                 310                 315                 320 


Val Gly Asn Arg Phe Gln Gln Lys Leu Arg Ser Val Phe Arg Val Pro 
                325                 330                 335     


Ile Thr Trp Leu Gln Gly Lys Arg Glu Ser Met Ser Cys Arg Lys Ser 
            340                 345                 350         


Ser Ser Leu Arg Glu Met Glu Thr Phe Val Ser 
        355                 360             


<210>  3
<211>  1277
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Asp Pro Gly Leu Gln Pro Gly Asn Phe Ser Ala Asp Glu Ala Gly 
1               5                   10                  15      


Ala Gln Leu Phe Ala Gln Ser Tyr Asn Ser Ser Ala Glu Gln Val Leu 
            20                  25                  30          


Phe Gln Ser Val Ala Ala Ser Trp Ala His Asp Thr Asn Ile Thr Ala 
        35                  40                  45              


Glu Asn Ala Arg Arg Gln Glu Glu Ala Ala Leu Leu Ser Gln Glu Phe 
    50                  55                  60                  


Ala Glu Ala Trp Gly Gln Lys Ala Lys Glu Leu Tyr Glu Pro Ile Trp 
65                  70                  75                  80  


Gln Asn Phe Thr Asp Pro Gln Leu Arg Arg Ile Ile Gly Ala Val Arg 
                85                  90                  95      


Thr Leu Gly Ser Ala Asn Leu Pro Leu Ala Lys Arg Gln Gln Tyr Asn 
            100                 105                 110         


Ala Leu Leu Ser Asn Met Ser Arg Ile Tyr Ser Thr Ala Lys Val Cys 
        115                 120                 125             


Leu Pro Asn Lys Thr Ala Thr Cys Trp Ser Leu Asp Pro Asp Leu Thr 
    130                 135                 140                 


Asn Ile Leu Ala Ser Ser Arg Ser Tyr Ala Met Leu Leu Phe Ala Trp 
145                 150                 155                 160 


Glu Gly Trp His Asn Ala Ala Gly Ile Pro Leu Lys Pro Leu Tyr Glu 
                165                 170                 175     


Asp Phe Thr Ala Leu Ser Asn Glu Ala Tyr Lys Gln Asp Gly Phe Thr 
            180                 185                 190         


Asp Thr Gly Ala Tyr Trp Arg Ser Trp Tyr Asn Ser Pro Thr Phe Glu 
        195                 200                 205             


Asp Asp Leu Glu His Leu Tyr Gln Gln Leu Glu Pro Leu Tyr Leu Asn 
    210                 215                 220                 


Leu His Ala Phe Val Arg Arg Ala Leu His Arg Arg Tyr Gly Asp Arg 
225                 230                 235                 240 


Tyr Ile Asn Leu Arg Gly Pro Ile Pro Ala His Leu Leu Gly Asp Met 
                245                 250                 255     


Trp Ala Gln Ser Trp Glu Asn Ile Tyr Asp Met Val Val Pro Phe Pro 
            260                 265                 270         


Asp Lys Pro Asn Leu Asp Val Thr Ser Thr Met Leu Gln Gln Gly Trp 
        275                 280                 285             


Asn Ala Thr His Met Phe Arg Val Ala Glu Glu Phe Phe Thr Ser Leu 
    290                 295                 300                 


Glu Leu Ser Pro Met Pro Pro Glu Phe Trp Glu Gly Ser Met Leu Glu 
305                 310                 315                 320 


Lys Pro Ala Asp Gly Arg Glu Val Val Cys His Ala Ser Ala Trp Asp 
                325                 330                 335     


Phe Tyr Asn Arg Lys Asp Phe Arg Ile Lys Gln Cys Thr Arg Val Thr 
            340                 345                 350         


Met Asp Gln Leu Ser Thr Val His His Glu Met Gly His Ile Gln Tyr 
        355                 360                 365             


Tyr Leu Gln Tyr Lys Asp Leu Pro Val Ser Leu Arg Arg Gly Ala Asn 
    370                 375                 380                 


Pro Gly Phe His Glu Ala Ile Gly Asp Val Leu Ala Leu Ser Val Ser 
385                 390                 395                 400 


Thr Pro Glu His Leu His Lys Ile Gly Leu Leu Asp Arg Val Thr Asn 
                405                 410                 415     


Asp Thr Glu Ser Asp Ile Asn Tyr Leu Leu Lys Met Ala Leu Glu Lys 
            420                 425                 430         


Ile Ala Phe Leu Pro Phe Gly Tyr Leu Val Asp Gln Trp Arg Trp Gly 
        435                 440                 445             


Val Phe Ser Gly Arg Thr Pro Pro Ser Arg Tyr Asn Phe Asp Trp Trp 
    450                 455                 460                 


Tyr Leu Arg Thr Lys Tyr Gln Gly Ile Cys Pro Pro Val Thr Arg Asn 
465                 470                 475                 480 


Glu Thr His Phe Asp Ala Gly Ala Lys Phe His Val Pro Asn Val Thr 
                485                 490                 495     


Pro Tyr Ile Arg Tyr Phe Val Ser Phe Val Leu Gln Phe Gln Phe His 
            500                 505                 510         


Glu Ala Leu Cys Lys Glu Ala Gly Tyr Glu Gly Pro Leu His Gln Cys 
        515                 520                 525             


Asp Ile Tyr Arg Ser Thr Lys Ala Gly Ala Lys Leu Arg Lys Val Leu 
    530                 535                 540                 


Gln Ala Gly Ser Ser Arg Pro Trp Gln Glu Val Leu Lys Asp Met Val 
545                 550                 555                 560 


Gly Leu Asp Ala Leu Asp Ala Gln Pro Leu Leu Lys Tyr Phe Gln Pro 
                565                 570                 575     


Val Thr Gln Trp Leu Gln Glu Gln Asn Gln Gln Asn Gly Glu Val Leu 
            580                 585                 590         


Gly Trp Pro Glu Tyr Gln Trp His Pro Pro Leu Pro Asp Asn Tyr Pro 
        595                 600                 605             


Glu Gly Ile Asp Leu Val Thr Asp Glu Ala Glu Ala Ser Lys Phe Val 
    610                 615                 620                 


Glu Glu Tyr Asp Arg Thr Ser Gln Val Val Trp Asn Glu Tyr Ala Glu 
625                 630                 635                 640 


Ala Asn Trp Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile 
                645                 650                 655     


Leu Leu Gln Lys Asn Met Gln Ile Ala Asn His Thr Leu Lys Tyr Gly 
            660                 665                 670         


Thr Gln Ala Arg Lys Phe Asp Val Asn Gln Leu Gln Asn Thr Thr Ile 
        675                 680                 685             


Lys Arg Ile Ile Lys Lys Val Gln Asp Leu Glu Arg Ala Ala Leu Pro 
    690                 695                 700                 


Ala Gln Glu Leu Glu Glu Tyr Asn Lys Ile Leu Leu Asp Met Glu Thr 
705                 710                 715                 720 


Thr Tyr Ser Val Ala Thr Val Cys His Pro Asn Gly Ser Cys Leu Gln 
                725                 730                 735     


Leu Glu Pro Asp Leu Thr Asn Val Met Ala Thr Ser Arg Lys Tyr Glu 
            740                 745                 750         


Asp Leu Leu Trp Ala Trp Glu Gly Trp Arg Asp Lys Ala Gly Arg Ala 
        755                 760                 765             


Ile Leu Gln Phe Tyr Pro Lys Tyr Val Glu Leu Ile Asn Gln Ala Ala 
    770                 775                 780                 


Arg Leu Asn Gly Tyr Val Asp Ala Gly Asp Ser Trp Arg Ser Met Tyr 
785                 790                 795                 800 


Glu Thr Pro Ser Leu Glu Gln Asp Leu Glu Arg Leu Phe Gln Glu Leu 
                805                 810                 815     


Gln Pro Leu Tyr Leu Asn Leu His Ala Tyr Val Arg Arg Ala Leu His 
            820                 825                 830         


Arg His Tyr Gly Ala Gln His Ile Asn Leu Glu Gly Pro Ile Pro Ala 
        835                 840                 845             


His Leu Leu Gly Asn Met Trp Ala Gln Thr Trp Ser Asn Ile Tyr Asp 
    850                 855                 860                 


Leu Val Val Pro Phe Pro Ser Ala Pro Ser Met Asp Thr Thr Glu Ala 
865                 870                 875                 880 


Met Leu Lys Gln Gly Trp Thr Pro Arg Arg Met Phe Lys Glu Ala Asp 
                885                 890                 895     


Asp Phe Phe Thr Ser Leu Gly Leu Leu Pro Val Pro Pro Glu Phe Trp 
            900                 905                 910         


Asn Lys Ser Met Leu Glu Lys Pro Thr Asp Gly Arg Glu Val Val Cys 
        915                 920                 925             


His Ala Ser Ala Trp Asp Phe Tyr Asn Gly Lys Asp Phe Arg Ile Lys 
    930                 935                 940                 


Gln Cys Thr Thr Val Asn Leu Glu Asp Leu Val Val Ala His His Glu 
945                 950                 955                 960 


Met Gly His Ile Gln Tyr Phe Met Gln Tyr Lys Asp Leu Pro Val Ala 
                965                 970                 975     


Leu Arg Glu Gly Ala Asn Pro Gly Phe His Glu Ala Ile Gly Asp Val 
            980                 985                 990         


Leu Ala Leu Ser Val Ser Thr Pro  Lys His Leu His Ser  Leu Asn Leu 
        995                 1000                 1005             


Leu Ser  Ser Glu Gly Gly Ser  Asp Glu His Asp Ile  Asn Phe Leu 
    1010                 1015                 1020             


Met Lys  Met Ala Leu Asp Lys  Ile Ala Phe Ile Pro  Phe Ser Tyr 
    1025                 1030                 1035             


Leu Val  Asp Gln Trp Arg Trp  Arg Val Phe Asp Gly  Ser Ile Thr 
    1040                 1045                 1050             


Lys Glu  Asn Tyr Asn Gln Glu  Trp Trp Ser Leu Arg  Leu Lys Tyr 
    1055                 1060                 1065             


Gln Gly  Leu Cys Pro Pro Val  Pro Arg Thr Gln Gly  Asp Phe Asp 
    1070                 1075                 1080             


Pro Gly  Ala Lys Phe His Ile  Pro Ser Ser Val Pro  Tyr Ile Arg 
    1085                 1090                 1095             


Tyr Phe  Val Ser Phe Ile Ile  Gln Phe Gln Phe His  Glu Ala Leu 
    1100                 1105                 1110             


Cys Gln  Ala Ala Gly His Thr  Gly Pro Leu His Lys  Cys Asp Ile 
    1115                 1120                 1125             


Tyr Gln  Ser Lys Glu Ala Gly  Gln Arg Leu Ala Thr  Ala Met Lys 
    1130                 1135                 1140             


Leu Gly  Phe Ser Arg Pro Trp  Pro Glu Ala Met Gln  Leu Ile Thr 
    1145                 1150                 1155             


Gly Gln  Pro Asn Met Ser Ala  Ser Ala Met Leu Ser  Tyr Phe Lys 
    1160                 1165                 1170             


Pro Leu  Leu Asp Trp Leu Arg  Thr Glu Asn Glu Leu  His Gly Glu 
    1175                 1180                 1185             


Lys Leu  Gly Trp Pro Gln Tyr  Asn Trp Thr Pro Asn  Ser Ala Arg 
    1190                 1195                 1200             


Ser Glu  Gly Pro Leu Pro Asp  Ser Gly Arg Val Ser  Phe Leu Gly 
    1205                 1210                 1215             


Leu Asp  Leu Asp Ala Gln Gln  Ala Arg Val Gly Gln  Trp Leu Leu 
    1220                 1225                 1230             


Leu Phe  Leu Gly Ile Ala Leu  Leu Val Ala Thr Leu  Gly Leu Ser 
    1235                 1240                 1245             


Gln Arg  Leu Phe Ser Ile Arg  His Arg Ser Leu His  Arg His Ser 
    1250                 1255                 1260             


His Gly  Pro Gln Phe Gly Ser  Glu Val Glu Leu Arg  His Ser 
    1265                 1270                 1275         


<210>  4
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  4

Leu Thr Leu Gly Asn Thr Thr Ser Ser Val Ile Leu Thr Asn Tyr Met 
1               5                   10                  15      


Asp Thr Gln Tyr Tyr Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Thr 
            20                  25                  30          


Phe Lys Val Val Phe Asp Thr Gly Ser Ser Asn Val Trp Val Pro Ser 
        35                  40                  45              


Ser Lys Cys Ser Arg Leu Tyr Thr Ala Cys Val Tyr His Lys Leu Phe 
    50                  55                  60                  


Asp Ala Ser Asp Ser Ser Ser Tyr Lys His Asn Gly Thr Glu Leu Thr 
65                  70                  75                  80  


Leu Arg Tyr Ser Thr Gly Thr Val Ser Gly Phe Leu Ser Gln Asp Ile 
                85                  90                  95      


Ile Thr Val Gly Gly Ile Thr Val Thr Gln Met Phe Gly Glu Val Thr 
            100                 105                 110         


Glu Met Pro Ala Leu Pro Phe Met Leu Ala Glu Phe Asp Gly Val Val 
        115                 120                 125             


Gly Met Gly Phe Ile Glu Gln Ala Ile Gly Arg Val Thr Pro Ile Phe 
    130                 135                 140                 


Asp Asn Ile Ile Ser Gln Gly Val Leu Lys Glu Asp Val Phe Ser Phe 
145                 150                 155                 160 


Tyr Tyr Asn Arg Asp Ser Glu Asn Ser Gln Ser Leu Gly Gly Gln Ile 
                165                 170                 175     


Val Leu Gly Gly Ser Asp Pro Gln His Tyr Glu Gly Asn Phe His Tyr 
            180                 185                 190         


Ile Asn Leu Ile Lys Thr Gly Val Trp Gln Ile Gln Met Lys Gly Val 
        195                 200                 205             


Ser Val Gly Ser Ser Thr Leu Leu Cys Glu Asp Gly Cys Leu Ala Leu 
    210                 215                 220                 


Val Asp Thr Gly Ala Ser Tyr Ile Ser Gly Ser Thr Ser Ser Ile Glu 
225                 230                 235                 240 


Lys Leu Met Glu Ala Leu Gly Ala Lys Lys Arg Leu Phe Asp Tyr Val 
                245                 250                 255     


Val Lys Cys Asn Glu Gly Pro Thr Leu Pro Asp Ile Ser Phe His Leu 
            260                 265                 270         


Gly Gly Lys Glu Tyr Thr Leu Thr Ser Ala Asp Tyr Val Phe Gln Glu 
        275                 280                 285             


Ser Tyr Ser Ser Lys Lys Leu Cys Thr Leu Ala Ile His Ala Met Asp 
    290                 295                 300                 


Ile Pro Pro Pro Thr Gly Pro Thr Trp Ala Leu Gly Ala Thr Phe Ile 
305                 310                 315                 320 


Arg Lys Phe Tyr Thr Glu Phe Asp Arg Arg Asn Asn Arg Ile Gly Phe 
                325                 330                 335     


Ala Leu Ala Arg 
            340 


<210>  5
<211>  984
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Thr Lys Gly Tyr His Ser Leu Pro Glu Gly Leu Asp Met Glu 
1               5                   10                  15      


Arg Arg Trp Gly Gln Val Ser Gln Ala Val Glu Arg Ser Ser Leu Gly 
            20                  25                  30          


Pro Thr Glu Arg Thr Asp Glu Asn Asn Tyr Met Glu Ile Val Asn Val 
        35                  40                  45              


Ser Cys Val Ser Gly Ala Ile Pro Asn Asn Ser Thr Gln Gly Ser Ser 
    50                  55                  60                  


Lys Glu Lys Gln Glu Leu Leu Pro Cys Leu Gln Gln Asp Asn Asn Arg 
65                  70                  75                  80  


Pro Gly Ile Leu Thr Ser Asp Ile Lys Thr Glu Leu Glu Ser Lys Glu 
                85                  90                  95      


Leu Ser Ala Thr Val Ala Glu Ser Met Gly Leu Tyr Met Asp Ser Val 
            100                 105                 110         


Arg Asp Ala Asp Tyr Ser Tyr Glu Gln Gln Asn Gln Gln Gly Ser Met 
        115                 120                 125             


Ser Pro Ala Lys Ile Tyr Gln Asn Val Glu Gln Leu Val Lys Phe Tyr 
    130                 135                 140                 


Lys Gly Asn Gly His Arg Pro Ser Thr Leu Ser Cys Val Asn Thr Pro 
145                 150                 155                 160 


Leu Arg Ser Phe Met Ser Asp Ser Gly Ser Ser Val Asn Gly Gly Val 
                165                 170                 175     


Met Arg Ala Ile Val Lys Ser Pro Ile Met Cys His Glu Lys Ser Pro 
            180                 185                 190         


Ser Val Cys Ser Pro Leu Asn Met Thr Ser Ser Val Cys Ser Pro Ala 
        195                 200                 205             


Gly Ile Asn Ser Val Ser Ser Thr Thr Ala Ser Phe Gly Ser Phe Pro 
    210                 215                 220                 


Val His Ser Pro Ile Thr Gln Gly Thr Pro Leu Thr Cys Ser Pro Asn 
225                 230                 235                 240 


Ala Glu Asn Arg Gly Ser Arg Ser His Ser Pro Ala His Ala Ser Asn 
                245                 250                 255     


Val Gly Ser Pro Leu Ser Ser Pro Leu Ser Ser Met Lys Ser Ser Ile 
            260                 265                 270         


Ser Ser Pro Pro Ser His Cys Ser Val Lys Ser Pro Val Ser Ser Pro 
        275                 280                 285             


Asn Asn Val Thr Leu Arg Ser Ser Val Ser Ser Pro Ala Asn Ile Asn 
    290                 295                 300                 


Asn Ser Arg Cys Ser Val Ser Ser Pro Ser Asn Thr Asn Asn Arg Ser 
305                 310                 315                 320 


Thr Leu Ser Ser Pro Ala Ala Ser Thr Val Gly Ser Ile Cys Ser Pro 
                325                 330                 335     


Val Asn Asn Ala Phe Ser Tyr Thr Ala Ser Gly Thr Ser Ala Gly Ser 
            340                 345                 350         


Ser Thr Leu Arg Asp Val Val Pro Ser Pro Asp Thr Gln Glu Lys Gly 
        355                 360                 365             


Ala Gln Glu Val Pro Phe Pro Lys Thr Glu Glu Val Glu Ser Ala Ile 
    370                 375                 380                 


Ser Asn Gly Val Thr Gly Gln Leu Asn Ile Val Gln Tyr Ile Lys Pro 
385                 390                 395                 400 


Glu Pro Asp Gly Ala Phe Ser Ser Ser Cys Leu Gly Gly Asn Ser Lys 
                405                 410                 415     


Ile Asn Ser Asp Ser Ser Phe Ser Val Pro Ile Lys Gln Glu Ser Thr 
            420                 425                 430         


Lys His Ser Cys Ser Gly Thr Ser Phe Lys Gly Asn Pro Thr Val Asn 
        435                 440                 445             


Pro Phe Pro Phe Met Asp Gly Ser Tyr Phe Ser Phe Met Asp Asp Lys 
    450                 455                 460                 


Asp Tyr Tyr Ser Leu Ser Gly Ile Leu Gly Pro Pro Val Pro Gly Phe 
465                 470                 475                 480 


Asp Gly Asn Cys Glu Gly Ser Gly Phe Pro Val Gly Ile Lys Gln Glu 
                485                 490                 495     


Pro Asp Asp Gly Ser Tyr Tyr Pro Glu Ala Ser Ile Pro Ser Ser Ala 
            500                 505                 510         


Ile Val Gly Val Asn Ser Gly Gly Gln Ser Phe His Tyr Arg Ile Gly 
        515                 520                 525             


Ala Gln Gly Thr Ile Ser Leu Ser Arg Ser Ala Arg Asp Gln Ser Phe 
    530                 535                 540                 


Gln His Leu Ser Ser Phe Pro Pro Val Asn Thr Leu Val Glu Ser Trp 
545                 550                 555                 560 


Lys Ser His Gly Asp Leu Ser Ser Arg Arg Ser Asp Gly Tyr Pro Val 
                565                 570                 575     


Leu Glu Tyr Ile Pro Glu Asn Val Ser Ser Ser Thr Leu Arg Ser Val 
            580                 585                 590         


Ser Thr Gly Ser Ser Arg Pro Ser Lys Ile Cys Leu Val Cys Gly Asp 
        595                 600                 605             


Glu Ala Ser Gly Cys His Tyr Gly Val Val Thr Cys Gly Ser Cys Lys 
    610                 615                 620                 


Val Phe Phe Lys Arg Ala Val Glu Gly Gln His Asn Tyr Leu Cys Ala 
625                 630                 635                 640 


Gly Arg Asn Asp Cys Ile Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro 
                645                 650                 655     


Ala Cys Arg Leu Gln Lys Cys Leu Gln Ala Gly Met Asn Leu Gly Ala 
            660                 665                 670         


Arg Lys Ser Lys Lys Leu Gly Lys Leu Lys Gly Ile His Glu Glu Gln 
        675                 680                 685             


Pro Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Gln Ser Pro 
    690                 695                 700                 


Glu Glu Gly Thr Thr Tyr Ile Ala Pro Ala Lys Glu Pro Ser Val Asn 
705                 710                 715                 720 


Thr Ala Leu Val Pro Gln Leu Ser Thr Ile Ser Arg Ala Leu Thr Pro 
                725                 730                 735     


Ser Pro Val Met Val Leu Glu Asn Ile Glu Pro Glu Ile Val Tyr Ala 
            740                 745                 750         


Gly Tyr Asp Ser Ser Lys Pro Asp Thr Ala Glu Asn Leu Leu Ser Thr 
        755                 760                 765             


Leu Asn Arg Leu Ala Gly Lys Gln Met Ile Gln Val Val Lys Trp Ala 
    770                 775                 780                 


Lys Val Leu Pro Gly Phe Lys Asn Leu Pro Leu Glu Asp Gln Ile Thr 
785                 790                 795                 800 


Leu Ile Gln Tyr Ser Trp Met Cys Leu Ser Ser Phe Ala Leu Ser Trp 
                805                 810                 815     


Arg Ser Tyr Lys His Thr Asn Ser Gln Phe Leu Tyr Phe Ala Pro Asp 
            820                 825                 830         


Leu Val Phe Asn Glu Glu Lys Met His Gln Ser Ala Met Tyr Glu Leu 
        835                 840                 845             


Cys Gln Gly Met His Gln Ile Ser Leu Gln Phe Val Arg Leu Gln Leu 
    850                 855                 860                 


Thr Phe Glu Glu Tyr Thr Ile Met Lys Val Leu Leu Leu Leu Ser Thr 
865                 870                 875                 880 


Ile Pro Lys Asp Gly Leu Lys Ser Gln Ala Ala Phe Glu Glu Met Arg 
                885                 890                 895     


Thr Asn Tyr Ile Lys Glu Leu Arg Lys Met Val Thr Lys Cys Pro Asn 
            900                 905                 910         


Asn Ser Gly Gln Ser Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
        915                 920                 925             


Asp Ser Met His Asp Leu Val Ser Asp Leu Leu Glu Phe Cys Phe Tyr 
    930                 935                 940                 


Thr Phe Arg Glu Ser His Ala Leu Lys Val Glu Phe Pro Ala Met Leu 
945                 950                 955                 960 


Val Glu Ile Ile Ser Asp Gln Leu Pro Lys Val Glu Ser Gly Asn Ala 
                965                 970                 975     


Lys Pro Leu Tyr Phe His Arg Lys 
            980                 


<210>  6
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Arg Val Tyr Ile His Pro Phe His Leu Val Ile His Asn Glu Ser 
1               5                   10                  15      


Thr Cys Glu Gln Leu Ala Lys Ala Asn Ala Gly Lys Pro Lys Asp Pro 
            20                  25                  30          


Thr Phe Ile Pro Ala Pro Ile Gln Ala Lys Thr Ser Pro Val Asp Glu 
        35                  40                  45              


Lys Ala Leu Gln Asp Gln Leu Val Leu Val Ala Ala Lys Leu Asp Thr 
    50                  55                  60                  


Glu Asp Lys Leu Arg Ala Ala Met Val Gly Met Leu Ala Asn Phe Leu 
65                  70                  75                  80  


Gly Phe Arg Ile Tyr Gly Met His Ser Glu Leu Trp Gly Val Val His 
                85                  90                  95      


Gly Ala Thr Val Leu Ser Pro Thr Ala Val Phe Gly Thr Leu Ala Ser 
            100                 105                 110         


Leu Tyr Leu Gly Ala Leu Asp His Thr Ala Asp Arg Leu Gln Ala Ile 
        115                 120                 125             


Leu Gly Val Pro Trp Lys Asp Lys Asn Cys Thr Ser Arg Leu Asp Ala 
    130                 135                 140                 


His Lys Val Leu Ser Ala Leu Gln Ala Val Gln Gly Leu Leu Val Ala 
145                 150                 155                 160 


Gln Gly Arg Ala Asp Ser Gln Ala Gln Leu Leu Leu Ser Thr Val Val 
                165                 170                 175     


Gly Val Phe Thr Ala Pro Gly Leu His Leu Lys Gln Pro Phe Val Gln 
            180                 185                 190         


Gly Leu Ala Leu Tyr Thr Pro Val Val Leu Pro Arg Ser Leu Asp Phe 
        195                 200                 205             


Thr Glu Leu Asp Val Ala Ala Glu Lys Ile Asp Arg Phe Met Gln Ala 
    210                 215                 220                 


Val Thr Gly Trp Lys Thr Gly Cys Ser Leu Met Gly Ala Ser Val Asp 
225                 230                 235                 240 


Ser Thr Leu Ala Phe Asn Thr Tyr Val His Phe Gln Gly Lys Met Lys 
                245                 250                 255     


Gly Phe Ser Leu Leu Ala Glu Pro Gln Glu Phe Trp Val Asp Asn Ser 
            260                 265                 270         


Thr Ser Val Ser Val Pro Met Leu Ser Gly Met Gly Thr Phe Gln His 
        275                 280                 285             


Trp Ser Asp Ile Gln Asp Asn Phe Ser Val Thr Gln Val Pro Phe Thr 
    290                 295                 300                 


Glu Ser Ala Cys Leu Leu Leu Ile Gln Pro His Tyr Ala Ser Asp Leu 
305                 310                 315                 320 


Asp Lys Val Glu Gly Leu Thr Phe Gln Gln Asn Ser Leu Asn Trp Met 
                325                 330                 335     


Lys Lys Leu Ser Pro Arg Thr Ile His Leu Thr Met Pro Gln Leu Val 
            340                 345                 350         


Leu Gln Gly Ser Tyr Asp Leu Gln Asp Leu Leu Ala Gln Ala Glu Leu 
        355                 360                 365             


Pro Ala Ile Leu His Thr Glu Leu Asn Leu Gln Lys Leu Ser Asn Asp 
    370                 375                 380                 


Arg Ile Arg Val Gly Glu Val Leu Asn Ser Ile Phe Phe Glu Leu Glu 
385                 390                 395                 400 


Ala Asp Glu Arg Glu Pro Thr Glu Ser Thr Gln Gln Leu Asn Lys Pro 
                405                 410                 415     


Glu Val Leu Glu Val Thr Leu Asn Arg Pro Phe Leu Phe Ala Val Tyr 
            420                 425                 430         


Asp Gln Ser Ala Thr Ala Leu His Phe Leu Gly Arg Val Ala Asn Pro 
        435                 440                 445             


Leu Ser Thr Ala 
    450         


<210>  7
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Arg Val Tyr Ile His Pro Phe His Leu 
1               5                   10  


<210>  8
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Arg Val Tyr Ile His Pro Phe 
1               5               


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  9

Arg Val Tyr Ile His Pro Phe 
1               5           


<210>  10
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  10

Val Tyr Ile His Pro Phe 
1               5       


