                         SEQUENCE LISTING

<110>  THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS 
       REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND 
       HUMAN SERVICES
       Arthos, James
       Fauci, Anthony  S.
       Goode, Diana
       Cicala, Claudia
 
<120>  USE OF ANTAGONISTS OF THE INTERACTION BETWEEN HIV GP120 AND ALPHA4BETA7 INTEGRIN

<130>  4239-77318-04

<150>  US 60/957,140
<151>  2007-08-21

<150>  US 60/920,880
<151>  2007-03-30

<150>  US 60/873,884
<151>  2006-12-07

<160>  34    

<170>  PatentIn version 3.3

<210>  1
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist

<400>  1

Cys Trp Leu Asp Val Cys 
1               5       


<210>  2
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide primer

<400>  2
ggtctctctg gttagaccag at                                              22


<210>  3
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide primer

<400>  3
ctgctagaga ttttccacac tg                                              22


<210>  4
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide probe

<400>  4
agtagtgtgt gcccgtctgt t                                               21


<210>  5
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist

<400>  5

Asp Glu Leu Pro Gln Leu Val Thr Leu Pro His Pro Asn Leu His Gly 
1               5                   10                  15      


Pro Glu Ile Leu Asp Val Pro Ser Thr 
            20                  25  


<210>  6
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist

<400>  6

Asp Glu Leu Pro Gln Leu Val Thr Leu 
1               5                   


<210>  7
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist

<400>  7

Leu His Gly Pro Glu Ile Leu Asp Val Pro Ser Thr 
1               5                   10          


<210>  8
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist

<400>  8

Gly Pro Glu Ile Leu Asp Val Pro Ser Thr 
1               5                   10  


<210>  9
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist

<400>  9

Val Thr Leu Pro His Pro Asn Leu His Gly Pro Glu Ile Leu 
1               5                   10                  


<210>  10
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist

<400>  10

Val Thr Leu Pro His Pro Asn Leu His Gly Pro Glu Ile Leu Asp Val 
1               5                   10                  15      


Pro Ser Thr 
            


<210>  11
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist

<400>  11

Glu Ile Leu Asp Val Pro Ser Thr 
1               5               


<210>  12
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist

<400>  12

Leu Asp Val Pro Ser Thr 
1               5       


<210>  13
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist

<400>  13

Glu Ile Leu Asp Val 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist

<400>  14

Leu Asp Val Pro Ser 
1               5   


<210>  15
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist

<400>  15

Leu Asp Val 
1           


<210>  16
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist

<400>  16

Asp Glu Leu Pro Gln Leu Val Thr Leu Pro His Pro Asn Leu His Gly 
1               5                   10                  15      


Pro Glu Ile Leu 
            20  


<210>  17
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-proline

<400>  17

Leu Thr Gly Xaa Leu Asp Ile 
1               5           


<210>  18
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is D-proline

<400>  18

Thr Gly Xaa Leu Asp Ile 
1               5       


<210>  19
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is D-proline

<400>  19

Gly Xaa Leu Asp Ile 
1               5   


<210>  20
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is D-proline

<400>  20

Xaa Leu Asp Ile 
1               


<210>  21
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is D-cysteine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is D-cysteine

<400>  21

Xaa Met Leu Asp Ile Xaa 
1               5       


<210>  22
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is D-cysteine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is D-cysteine

<400>  22

Xaa Leu Leu Asp Ile Xaa 
1               5       


<210>  23
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is D-cysteine

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is D-cysteine

<400>  23

Xaa Asn Leu Asp Xaa 
1               5   


<210>  24
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is D-cysteine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is D-cysteine

<400>  24

Xaa Tyr Leu Asp Ile Xaa 
1               5       


<210>  25
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is D-cysteine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is D-cysteine

<400>  25

Xaa Gly Tyr Leu Asp Ile Xaa 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is D-cysteine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is D-cysteine

<400>  26

Xaa Ala Trp Leu Asp Ile Xaa 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is D-cysteine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is D-cysteine

<400>  27

Xaa Leu Asp Ile Gly Asp Xaa 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is D-cysteine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is D-cysteine

<400>  28

Xaa Leu Asp Ile His Pro Xaa 
1               5           


<210>  29
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist

<400>  29

Cys Leu Asp Thr Cys 
1               5   


<210>  30
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is D-proline

<400>  30

Leu Asp Thr Ala Xaa Ala 
1               5       


<210>  31
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist

<400>  31

Cys Asp Leu Trp Cys 
1               5   


<210>  32
<211>  40
<212>  PRT
<213>  homo sapiens sequence

<400>  32

Cys Ser Phe Asn Ile Ser Thr Ser Ile Arg Gly Lys Val Gln Lys Glu 
1               5                   10                  15      


Tyr Ala Phe Phe Tyr Lys Leu Asp Ile Ile Pro Ile Asp Asn Asp Thr 
            20                  25                  30          


Thr Ser Tyr Ser Leu Thr Ser Cys 
        35                  40  


<210>  33
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  consensus sequence for all V2 loops of HXB2 HIV-1

<400>  33

Cys Ser Phe Asn Ile Thr Thr Glu Ile Arg Asp Lys Lys Lys Lys Val 
1               5                   10                  15      


Tyr Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asp Asn Asn 
            20                  25                  30          


Ser Tyr Arg Leu Ile Asn Cys 
        35                  


<210>  34
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide integrin antagonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any D amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  34

Xaa Leu Asp Val Xaa 
1               5   


