                         SEQUENCE LISTING

<110>  Deciphera Pharmaceuticals, LLC
       Flynn, Daniel
       Petillo, Peter
       Kaufman, Michael
 
<120>  KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE 
       DISEASES AND OTHER PROLIFERATIVE DISEASES

<130>  39237-PCT

<150>  US 60/913,216
<151>  2007-04-20

<160>  10    

<170>  PatentIn version 3.3

<210>  1
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Thr Ser Met Asp Pro Ser Ser Pro Asn Tyr Asp Lys Trp Glu Met 
1               5                   10                  15      


Glu Arg Thr Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr 
            20                  25                  30          


Gly Glu Val Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala 
        35                  40                  45              


Val Lys Thr Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys 
    50                  55                  60                  


Glu Ala Ala Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu 
65                  70                  75                  80  


Leu Gly Val Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe 
                85                  90                  95      


Met Thr Tyr Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln 
            100                 105                 110         


Glu Val Asn Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser 
        115                 120                 125             


Ala Met Glu Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala 
    130                 135                 140                 


Ala Arg Asn Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp 
145                 150                 155                 160 


Phe Gly Leu Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala 
                165                 170                 175     


Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr 
            180                 185                 190         


Asn Lys Phe Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu 
        195                 200                 205             


Trp Glu Ile Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu 
    210                 215                 220                 


Ser Gln Val Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro 
225                 230                 235                 240 


Glu Gly Cys Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln 
                245                 250                 255     


Trp Asn Pro Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe 
            260                 265                 270         


Glu Thr Met Phe Gln Glu 
        275             


<210>  2
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Thr Ser Met Asp Pro Ser Ser Pro Asn Tyr Asp Lys Trp Glu Met 
1               5                   10                  15      


Glu Arg Thr Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr 
            20                  25                  30          


Gly Glu Val Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala 
        35                  40                  45              


Val Lys Thr Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys 
    50                  55                  60                  


Glu Ala Ala Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu 
65                  70                  75                  80  


Leu Gly Val Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Ile Glu Phe 
                85                  90                  95      


Met Thr Tyr Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln 
            100                 105                 110         


Glu Val Asn Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser 
        115                 120                 125             


Ala Met Glu Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala 
    130                 135                 140                 


Ala Arg Asn Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp 
145                 150                 155                 160 


Phe Gly Leu Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala 
                165                 170                 175     


Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr 
            180                 185                 190         


Asn Lys Phe Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu 
        195                 200                 205             


Trp Glu Ile Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu 
    210                 215                 220                 


Ser Gln Val Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro 
225                 230                 235                 240 


Glu Gly Cys Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln 
                245                 250                 255     


Trp Asn Pro Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe 
            260                 265                 270         


Glu Thr Met Phe Gln Glu 
        275             


<210>  3
<211>  2031
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Ile Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Asp Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Lys Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        515                 520                 525             


Ala Ala Ala Thr Thr Ser Gln Pro Val Leu Thr Ser Gln Gln Ile Glu 
    530                 535                 540                 


Thr Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Ser 
545                 550                 555                 560 


Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 
                565                 570                 575     


Val Gly Asp Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Arg 
            580                 585                 590         


Ala Phe Val Asp Asn Tyr Gly Val Ala Met Glu Met Ala Glu Lys Cys 
        595                 600                 605             


Cys Gln Ala Asn Ala Gln Phe Ala Glu Ile Ser Glu Asn Leu Arg Ala 
    610                 615                 620                 


Arg Ser Asn Lys Asp Ala Lys Asp Pro Thr Thr Lys Asn Ser Leu Glu 
625                 630                 635                 640 


Thr Leu Leu Tyr Lys Pro Val Asp Arg Val Thr Arg Ser Thr Leu Val 
                645                 650                 655     


Leu His Asp Leu Leu Lys His Thr Pro Ala Ser His Pro Asp His Pro 
            660                 665                 670         


Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile 
        675                 680                 685             


Asn Glu Glu Ile Thr Pro Arg Arg Gln Ser Met Thr Val Lys Lys Gly 
    690                 695                 700                 


Glu His Arg Gln Leu Leu Lys Asp Ser Phe Met Val Glu Leu Val Glu 
705                 710                 715                 720 


Gly Ala Arg Lys Leu Arg His Val Phe Leu Phe Thr Asp Leu Leu Leu 
                725                 730                 735     


Cys Thr Lys Leu Lys Lys Gln Ser Gly Gly Lys Thr Gln Gln Tyr Asp 
            740                 745                 750         


Cys Lys Trp Tyr Ile Pro Leu Thr Asp Leu Ser Phe Gln Met Val Asp 
        755                 760                 765             


Glu Leu Glu Ala Val Pro Asn Ile Pro Leu Val Pro Asp Glu Glu Leu 
    770                 775                 780                 


Asp Ala Leu Lys Ile Lys Ile Ser Gln Ile Lys Ser Asp Ile Gln Arg 
785                 790                 795                 800 


Glu Lys Arg Ala Asn Lys Gly Ser Lys Ala Thr Glu Arg Leu Lys Lys 
                805                 810                 815     


Lys Leu Ser Glu Gln Glu Ser Leu Leu Leu Leu Met Ser Pro Ser Met 
            820                 825                 830         


Ala Phe Arg Val His Ser Arg Asn Gly Lys Ser Tyr Thr Phe Leu Ile 
        835                 840                 845             


Ser Ser Asp Tyr Glu Arg Ala Glu Trp Arg Glu Asn Ile Arg Glu Gln 
    850                 855                 860                 


Gln Lys Lys Cys Phe Arg Ser Phe Ser Leu Thr Ser Val Glu Leu Gln 
865                 870                 875                 880 


Met Leu Thr Asn Ser Cys Val Lys Leu Gln Thr Val His Ser Ile Pro 
                885                 890                 895     


Leu Thr Ile Asn Lys Glu Asp Asp Glu Ser Pro Gly Leu Tyr Gly Phe 
            900                 905                 910         


Leu Asn Val Ile Val His Ser Ala Thr Gly Phe Lys Gln Ser Ser Lys 
        915                 920                 925             


Ala Leu Gln Arg Pro Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser 
    930                 935                 940                 


Glu Ala Ala Arg Trp Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser 
945                 950                 955                 960 


Glu Asn Asp Pro Asn Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser 
                965                 970                 975     


Gly Asp Asn Thr Leu Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu 
            980                 985                 990         


Gly Tyr Asn His Asn Gly Glu Trp  Cys Glu Ala Gln Thr  Lys Asn Gly 
        995                 1000                 1005             


Gln Gly  Trp Val Pro Ser Asn  Tyr Ile Thr Pro Val  Asn Ser Leu 
    1010                 1015                 1020             


Glu Lys  His Ser Trp Tyr His  Gly Pro Val Ser Arg  Asn Ala Ala 
    1025                 1030                 1035             


Glu Tyr  Pro Leu Ser Ser Gly  Ile Asn Gly Ser Phe  Leu Val Arg 
    1040                 1045                 1050             


Glu Ser  Glu Ser Ser Pro Ser  Gln Arg Ser Ile Ser  Leu Arg Tyr 
    1055                 1060                 1065             


Glu Gly  Arg Val Tyr His Tyr  Arg Ile Asn Thr Ala  Ser Asp Gly 
    1070                 1075                 1080             


Lys Leu  Tyr Val Ser Ser Glu  Ser Arg Phe Asn Thr  Leu Ala Glu 
    1085                 1090                 1095             


Leu Val  His His His Ser Thr  Val Ala Asp Gly Leu  Ile Thr Thr 
    1100                 1105                 1110             


Leu His  Tyr Pro Ala Pro Lys  Arg Asn Lys Pro Thr  Val Tyr Gly 
    1115                 1120                 1125             


Val Ser  Pro Asn Tyr Asp Lys  Trp Glu Met Glu Arg  Thr Asp Ile 
    1130                 1135                 1140             


Thr Met  Lys His Lys Leu Gly  Gly Gly Gln Tyr Gly  Glu Val Tyr 
    1145                 1150                 1155             


Glu Gly  Val Trp Lys Lys Tyr  Ser Leu Thr Val Ala  Val Lys Thr 
    1160                 1165                 1170             


Leu Lys  Glu Asp Thr Met Glu  Val Glu Glu Phe Leu  Lys Glu Ala 
    1175                 1180                 1185             


Ala Val  Met Lys Glu Ile Lys  His Pro Asn Leu Val  Gln Leu Leu 
    1190                 1195                 1200             


Gly Val  Cys Thr Arg Glu Pro  Pro Phe Tyr Ile Ile  Thr Glu Phe 
    1205                 1210                 1215             


Met Thr  Tyr Gly Asn Leu Leu  Asp Tyr Leu Arg Glu  Cys Asn Arg 
    1220                 1225                 1230             


Gln Glu  Val Asn Ala Val Val  Leu Leu Tyr Met Ala  Thr Gln Ile 
    1235                 1240                 1245             


Ser Ser  Ala Met Glu Tyr Leu  Glu Lys Lys Asn Phe  Ile His Arg 
    1250                 1255                 1260             


Asp Leu  Ala Ala Arg Asn Cys  Leu Val Gly Glu Asn  His Leu Val 
    1265                 1270                 1275             


Lys Val  Ala Asp Phe Gly Leu  Ser Arg Leu Met Thr  Gly Asp Thr 
    1280                 1285                 1290             


Tyr Thr  Ala His Ala Gly Ala  Lys Phe Pro Ile Lys  Trp Thr Ala 
    1295                 1300                 1305             


Pro Glu  Ser Leu Ala Tyr Asn  Lys Phe Ser Ile Lys  Ser Asp Val 
    1310                 1315                 1320             


Trp Ala  Phe Gly Val Leu Leu  Trp Glu Ile Ala Thr  Tyr Gly Met 
    1325                 1330                 1335             


Ser Pro  Tyr Pro Gly Ile Asp  Arg Ser Gln Val Tyr  Glu Leu Leu 
    1340                 1345                 1350             


Glu Lys  Asp Tyr Arg Met Lys  Arg Pro Glu Gly Cys  Pro Glu Lys 
    1355                 1360                 1365             


Val Tyr  Glu Leu Met Arg Ala  Cys Trp Gln Trp Asn  Pro Ser Asp 
    1370                 1375                 1380             


Arg Pro  Ser Phe Ala Glu Ile  His Gln Ala Phe Glu  Thr Met Phe 
    1385                 1390                 1395             


Gln Glu  Ser Ser Ile Ser Asp  Glu Val Glu Lys Glu  Leu Gly Lys 
    1400                 1405                 1410             


Gln Gly  Val Arg Gly Ala Val  Thr Thr Leu Leu Gln  Ala Pro Glu 
    1415                 1420                 1425             


Leu Pro  Thr Lys Thr Arg Thr  Ser Arg Arg Ala Ala  Glu His Arg 
    1430                 1435                 1440             


Asp Thr  Thr Asp Val Pro Glu  Met Pro His Ser Lys  Gly Gln Gly 
    1445                 1450                 1455             


Glu Ser  Asp Pro Leu Asp His  Glu Pro Ala Val Ser  Pro Leu Leu 
    1460                 1465                 1470             


Pro Arg  Lys Glu Arg Gly Pro  Pro Glu Gly Gly Leu  Asn Glu Asp 
    1475                 1480                 1485             


Glu Arg  Leu Leu Pro Lys Asp  Lys Lys Thr Asn Leu  Phe Ser Ala 
    1490                 1495                 1500             


Leu Ile  Lys Lys Lys Lys Lys  Thr Ala Pro Thr Pro  Pro Lys Arg 
    1505                 1510                 1515             


Ser Ser  Ser Phe Arg Glu Met  Asp Gly Gln Pro Glu  Arg Arg Gly 
    1520                 1525                 1530             


Ala Gly  Glu Glu Glu Gly Arg  Asp Ile Ser Asn Gly  Ala Leu Ala 
    1535                 1540                 1545             


Phe Thr  Pro Leu Asp Thr Ala  Asp Pro Ala Lys Ser  Pro Lys Pro 
    1550                 1555                 1560             


Ser Asn  Gly Ala Gly Val Pro  Asn Gly Ala Leu Arg  Glu Ser Gly 
    1565                 1570                 1575             


Gly Ser  Gly Phe Arg Ser Pro  His Leu Trp Lys Lys  Ser Ser Thr 
    1580                 1585                 1590             


Leu Thr  Ser Ser Arg Leu Ala  Thr Gly Glu Glu Glu  Gly Gly Gly 
    1595                 1600                 1605             


Ser Ser  Ser Lys Arg Phe Leu  Arg Ser Cys Ser Val  Ser Cys Val 
    1610                 1615                 1620             


Pro His  Gly Ala Lys Asp Thr  Glu Trp Arg Ser Val  Thr Leu Pro 
    1625                 1630                 1635             


Arg Asp  Leu Gln Ser Thr Gly  Arg Gln Phe Asp Ser  Ser Thr Phe 
    1640                 1645                 1650             


Gly Gly  His Lys Ser Glu Lys  Pro Ala Leu Pro Arg  Lys Arg Ala 
    1655                 1660                 1665             


Gly Glu  Asn Arg Ser Asp Gln  Val Thr Arg Gly Thr  Val Thr Pro 
    1670                 1675                 1680             


Pro Pro  Arg Leu Val Lys Lys  Asn Glu Glu Ala Ala  Asp Glu Val 
    1685                 1690                 1695             


Phe Lys  Asp Ile Met Glu Ser  Ser Pro Gly Ser Ser  Pro Pro Asn 
    1700                 1705                 1710             


Leu Thr  Pro Lys Pro Leu Arg  Arg Gln Val Thr Val  Ala Pro Ala 
    1715                 1720                 1725             


Ser Gly  Leu Pro His Lys Glu  Glu Ala Trp Lys Gly  Ser Ala Leu 
    1730                 1735                 1740             


Gly Thr  Pro Ala Ala Ala Glu  Pro Val Thr Pro Thr  Ser Lys Ala 
    1745                 1750                 1755             


Gly Ser  Gly Ala Pro Arg Gly  Thr Ser Lys Gly Pro  Ala Glu Glu 
    1760                 1765                 1770             


Ser Arg  Val Arg Arg His Lys  His Ser Ser Glu Ser  Pro Gly Arg 
    1775                 1780                 1785             


Asp Lys  Gly Lys Leu Ser Lys  Leu Lys Pro Ala Pro  Pro Pro Pro 
    1790                 1795                 1800             


Pro Ala  Ala Ser Ala Gly Lys  Ala Gly Gly Lys Pro  Ser Gln Arg 
    1805                 1810                 1815             


Pro Gly  Gln Glu Ala Ala Gly  Glu Ala Val Leu Gly  Ala Lys Thr 
    1820                 1825                 1830             


Lys Ala  Thr Ser Leu Val Asp  Ala Val Asn Ser Asp  Ala Ala Lys 
    1835                 1840                 1845             


Pro Ser  Gln Pro Ala Glu Gly  Leu Lys Lys Pro Val  Leu Pro Ala 
    1850                 1855                 1860             


Thr Pro  Lys Pro His Pro Ala  Lys Pro Ser Gly Thr  Pro Ile Ser 
    1865                 1870                 1875             


Pro Ala  Pro Val Pro Leu Ser  Thr Leu Pro Ser Ala  Ser Ser Ala 
    1880                 1885                 1890             


Leu Ala  Gly Asp Gln Pro Ser  Ser Thr Ala Phe Ile  Pro Leu Ile 
    1895                 1900                 1905             


Ser Thr  Arg Val Ser Leu Arg  Lys Thr Arg Gln Pro  Pro Glu Arg 
    1910                 1915                 1920             


Ala Ser  Gly Ala Ile Thr Lys  Gly Val Val Leu Asp  Ser Thr Glu 
    1925                 1930                 1935             


Ala Leu  Cys Leu Ala Ile Ser  Gly Asn Ser Glu Gln  Met Ala Ser 
    1940                 1945                 1950             


His Ser  Ala Val Leu Glu Ala  Gly Lys Asn Leu Tyr  Thr Phe Cys 
    1955                 1960                 1965             


Val Ser  Tyr Val Asp Ser Ile  Gln Gln Met Arg Asn  Lys Phe Ala 
    1970                 1975                 1980             


Phe Arg  Glu Ala Ile Asn Lys  Leu Glu Asn Asn Leu  Arg Glu Leu 
    1985                 1990                 1995             


Gln Ile  Cys Pro Ala Ser Ala  Gly Ser Gly Pro Ala  Ala Thr Gln 
    2000                 2005                 2010             


Asp Phe  Ser Lys Leu Leu Ser  Ser Val Lys Glu Ile  Ser Asp Ile 
    2015                 2020                 2025             


Val Gln  Arg 
    2030     


<210>  4
<211>  2006
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Ile Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Asp Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Lys Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        515                 520                 525             


Ala Ala Ala Thr Thr Ser Gln Pro Val Leu Thr Ser Gln Gln Ile Glu 
    530                 535                 540                 


Thr Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Ser 
545                 550                 555                 560 


Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 
                565                 570                 575     


Val Gly Asp Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Arg 
            580                 585                 590         


Ala Phe Val Asp Asn Tyr Gly Val Ala Met Glu Met Ala Glu Lys Cys 
        595                 600                 605             


Cys Gln Ala Asn Ala Gln Phe Ala Glu Ile Ser Glu Asn Leu Arg Ala 
    610                 615                 620                 


Arg Ser Asn Lys Asp Ala Lys Asp Pro Thr Thr Lys Asn Ser Leu Glu 
625                 630                 635                 640 


Thr Leu Leu Tyr Lys Pro Val Asp Arg Val Thr Arg Ser Thr Leu Val 
                645                 650                 655     


Leu His Asp Leu Leu Lys His Thr Pro Ala Ser His Pro Asp His Pro 
            660                 665                 670         


Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile 
        675                 680                 685             


Asn Glu Glu Ile Thr Pro Arg Arg Gln Ser Met Thr Val Lys Lys Gly 
    690                 695                 700                 


Glu His Arg Gln Leu Leu Lys Asp Ser Phe Met Val Glu Leu Val Glu 
705                 710                 715                 720 


Gly Ala Arg Lys Leu Arg His Val Phe Leu Phe Thr Asp Leu Leu Leu 
                725                 730                 735     


Cys Thr Lys Leu Lys Lys Gln Ser Gly Gly Lys Thr Gln Gln Tyr Asp 
            740                 745                 750         


Cys Lys Trp Tyr Ile Pro Leu Thr Asp Leu Ser Phe Gln Met Val Asp 
        755                 760                 765             


Glu Leu Glu Ala Val Pro Asn Ile Pro Leu Val Pro Asp Glu Glu Leu 
    770                 775                 780                 


Asp Ala Leu Lys Ile Lys Ile Ser Gln Ile Lys Ser Asp Ile Gln Arg 
785                 790                 795                 800 


Glu Lys Arg Ala Asn Lys Gly Ser Lys Ala Thr Glu Arg Leu Lys Lys 
                805                 810                 815     


Lys Leu Ser Glu Gln Glu Ser Leu Leu Leu Leu Met Ser Pro Ser Met 
            820                 825                 830         


Ala Phe Arg Val His Ser Arg Asn Gly Lys Ser Tyr Thr Phe Leu Ile 
        835                 840                 845             


Ser Ser Asp Tyr Glu Arg Ala Glu Trp Arg Glu Asn Ile Arg Glu Gln 
    850                 855                 860                 


Gln Lys Lys Cys Phe Arg Ser Phe Ser Leu Thr Ser Val Glu Leu Gln 
865                 870                 875                 880 


Met Leu Thr Asn Ser Cys Val Lys Leu Gln Thr Val His Ser Ile Pro 
                885                 890                 895     


Leu Thr Ile Asn Lys Glu Glu Ala Leu Gln Arg Pro Val Ala Ser Asp 
            900                 905                 910         


Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp Asn Ser Lys Glu 
        915                 920                 925             


Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn Leu Phe Val Ala 
    930                 935                 940                 


Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu Ser Ile Thr Lys 
945                 950                 955                 960 


Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn Gly Glu Trp Cys 
                965                 970                 975     


Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro Ser Asn Tyr Ile 
            980                 985                 990         


Thr Pro Val Asn Ser Leu Glu Lys  His Ser Trp Tyr His  Gly Pro Val 
        995                 1000                 1005             


Ser Arg  Asn Ala Ala Glu Tyr  Pro Leu Ser Ser Gly  Ile Asn Gly 
    1010                 1015                 1020             


Ser Phe  Leu Val Arg Glu Ser  Glu Ser Ser Pro Ser  Gln Arg Ser 
    1025                 1030                 1035             


Ile Ser  Leu Arg Tyr Glu Gly  Arg Val Tyr His Tyr  Arg Ile Asn 
    1040                 1045                 1050             


Thr Ala  Ser Asp Gly Lys Leu  Tyr Val Ser Ser Glu  Ser Arg Phe 
    1055                 1060                 1065             


Asn Thr  Leu Ala Glu Leu Val  His His His Ser Thr  Val Ala Asp 
    1070                 1075                 1080             


Gly Leu  Ile Thr Thr Leu His  Tyr Pro Ala Pro Lys  Arg Asn Lys 
    1085                 1090                 1095             


Pro Thr  Val Tyr Gly Val Ser  Pro Asn Tyr Asp Lys  Trp Glu Met 
    1100                 1105                 1110             


Glu Arg  Thr Asp Ile Thr Met  Lys His Lys Leu Gly  Gly Gly Gln 
    1115                 1120                 1125             


Tyr Gly  Glu Val Tyr Glu Gly  Val Trp Lys Lys Tyr  Ser Leu Thr 
    1130                 1135                 1140             


Val Ala  Val Lys Thr Leu Lys  Glu Asp Thr Met Glu  Val Glu Glu 
    1145                 1150                 1155             


Phe Leu  Lys Glu Ala Ala Val  Met Lys Glu Ile Lys  His Pro Asn 
    1160                 1165                 1170             


Leu Val  Gln Leu Leu Gly Val  Cys Thr Arg Glu Pro  Pro Phe Tyr 
    1175                 1180                 1185             


Ile Ile  Thr Glu Phe Met Thr  Tyr Gly Asn Leu Leu  Asp Tyr Leu 
    1190                 1195                 1200             


Arg Glu  Cys Asn Arg Gln Glu  Val Asn Ala Val Val  Leu Leu Tyr 
    1205                 1210                 1215             


Met Ala  Thr Gln Ile Ser Ser  Ala Met Glu Tyr Leu  Glu Lys Lys 
    1220                 1225                 1230             


Asn Phe  Ile His Arg Asp Leu  Ala Ala Arg Asn Cys  Leu Val Gly 
    1235                 1240                 1245             


Glu Asn  His Leu Val Lys Val  Ala Asp Phe Gly Leu  Ser Arg Leu 
    1250                 1255                 1260             


Met Thr  Gly Asp Thr Tyr Thr  Ala His Ala Gly Ala  Lys Phe Pro 
    1265                 1270                 1275             


Ile Lys  Trp Thr Ala Pro Glu  Ser Leu Ala Tyr Asn  Lys Phe Ser 
    1280                 1285                 1290             


Ile Lys  Ser Asp Val Trp Ala  Phe Gly Val Leu Leu  Trp Glu Ile 
    1295                 1300                 1305             


Ala Thr  Tyr Gly Met Ser Pro  Tyr Pro Gly Ile Asp  Arg Ser Gln 
    1310                 1315                 1320             


Val Tyr  Glu Leu Leu Glu Lys  Asp Tyr Arg Met Lys  Arg Pro Glu 
    1325                 1330                 1335             


Gly Cys  Pro Glu Lys Val Tyr  Glu Leu Met Arg Ala  Cys Trp Gln 
    1340                 1345                 1350             


Trp Asn  Pro Ser Asp Arg Pro  Ser Phe Ala Glu Ile  His Gln Ala 
    1355                 1360                 1365             


Phe Glu  Thr Met Phe Gln Glu  Ser Ser Ile Ser Asp  Glu Val Glu 
    1370                 1375                 1380             


Lys Glu  Leu Gly Lys Gln Gly  Val Arg Gly Ala Val  Thr Thr Leu 
    1385                 1390                 1395             


Leu Gln  Ala Pro Glu Leu Pro  Thr Lys Thr Arg Thr  Ser Arg Arg 
    1400                 1405                 1410             


Ala Ala  Glu His Arg Asp Thr  Thr Asp Val Pro Glu  Met Pro His 
    1415                 1420                 1425             


Ser Lys  Gly Gln Gly Glu Ser  Asp Pro Leu Asp His  Glu Pro Ala 
    1430                 1435                 1440             


Val Ser  Pro Leu Leu Pro Arg  Lys Glu Arg Gly Pro  Pro Glu Gly 
    1445                 1450                 1455             


Gly Leu  Asn Glu Asp Glu Arg  Leu Leu Pro Lys Asp  Lys Lys Thr 
    1460                 1465                 1470             


Asn Leu  Phe Ser Ala Leu Ile  Lys Lys Lys Lys Lys  Thr Ala Pro 
    1475                 1480                 1485             


Thr Pro  Pro Lys Arg Ser Ser  Ser Phe Arg Glu Met  Asp Gly Gln 
    1490                 1495                 1500             


Pro Glu  Arg Arg Gly Ala Gly  Glu Glu Glu Gly Arg  Asp Ile Ser 
    1505                 1510                 1515             


Asn Gly  Ala Leu Ala Phe Thr  Pro Leu Asp Thr Ala  Asp Pro Ala 
    1520                 1525                 1530             


Lys Ser  Pro Lys Pro Ser Asn  Gly Ala Gly Val Pro  Asn Gly Ala 
    1535                 1540                 1545             


Leu Arg  Glu Ser Gly Gly Ser  Gly Phe Arg Ser Pro  His Leu Trp 
    1550                 1555                 1560             


Lys Lys  Ser Ser Thr Leu Thr  Ser Ser Arg Leu Ala  Thr Gly Glu 
    1565                 1570                 1575             


Glu Glu  Gly Gly Gly Ser Ser  Ser Lys Arg Phe Leu  Arg Ser Cys 
    1580                 1585                 1590             


Ser Val  Ser Cys Val Pro His  Gly Ala Lys Asp Thr  Glu Trp Arg 
    1595                 1600                 1605             


Ser Val  Thr Leu Pro Arg Asp  Leu Gln Ser Thr Gly  Arg Gln Phe 
    1610                 1615                 1620             


Asp Ser  Ser Thr Phe Gly Gly  His Lys Ser Glu Lys  Pro Ala Leu 
    1625                 1630                 1635             


Pro Arg  Lys Arg Ala Gly Glu  Asn Arg Ser Asp Gln  Val Thr Arg 
    1640                 1645                 1650             


Gly Thr  Val Thr Pro Pro Pro  Arg Leu Val Lys Lys  Asn Glu Glu 
    1655                 1660                 1665             


Ala Ala  Asp Glu Val Phe Lys  Asp Ile Met Glu Ser  Ser Pro Gly 
    1670                 1675                 1680             


Ser Ser  Pro Pro Asn Leu Thr  Pro Lys Pro Leu Arg  Arg Gln Val 
    1685                 1690                 1695             


Thr Val  Ala Pro Ala Ser Gly  Leu Pro His Lys Glu  Glu Ala Trp 
    1700                 1705                 1710             


Lys Gly  Ser Ala Leu Gly Thr  Pro Ala Ala Ala Glu  Pro Val Thr 
    1715                 1720                 1725             


Pro Thr  Ser Lys Ala Gly Ser  Gly Ala Pro Arg Gly  Thr Ser Lys 
    1730                 1735                 1740             


Gly Pro  Ala Glu Glu Ser Arg  Val Arg Arg His Lys  His Ser Ser 
    1745                 1750                 1755             


Glu Ser  Pro Gly Arg Asp Lys  Gly Lys Leu Ser Lys  Leu Lys Pro 
    1760                 1765                 1770             


Ala Pro  Pro Pro Pro Pro Ala  Ala Ser Ala Gly Lys  Ala Gly Gly 
    1775                 1780                 1785             


Lys Pro  Ser Gln Arg Pro Gly  Gln Glu Ala Ala Gly  Glu Ala Val 
    1790                 1795                 1800             


Leu Gly  Ala Lys Thr Lys Ala  Thr Ser Leu Val Asp  Ala Val Asn 
    1805                 1810                 1815             


Ser Asp  Ala Ala Lys Pro Ser  Gln Pro Ala Glu Gly  Leu Lys Lys 
    1820                 1825                 1830             


Pro Val  Leu Pro Ala Thr Pro  Lys Pro His Pro Ala  Lys Pro Ser 
    1835                 1840                 1845             


Gly Thr  Pro Ile Ser Pro Ala  Pro Val Pro Leu Ser  Thr Leu Pro 
    1850                 1855                 1860             


Ser Ala  Ser Ser Ala Leu Ala  Gly Asp Gln Pro Ser  Ser Thr Ala 
    1865                 1870                 1875             


Phe Ile  Pro Leu Ile Ser Thr  Arg Val Ser Leu Arg  Lys Thr Arg 
    1880                 1885                 1890             


Gln Pro  Pro Glu Arg Ala Ser  Gly Ala Ile Thr Lys  Gly Val Val 
    1895                 1900                 1905             


Leu Asp  Ser Thr Glu Ala Leu  Cys Leu Ala Ile Ser  Gly Asn Ser 
    1910                 1915                 1920             


Glu Gln  Met Ala Ser His Ser  Ala Val Leu Glu Ala  Gly Lys Asn 
    1925                 1930                 1935             


Leu Tyr  Thr Phe Cys Val Ser  Tyr Val Asp Ser Ile  Gln Gln Met 
    1940                 1945                 1950             


Arg Asn  Lys Phe Ala Phe Arg  Glu Ala Ile Asn Lys  Leu Glu Asn 
    1955                 1960                 1965             


Asn Leu  Arg Glu Leu Gln Ile  Cys Pro Ala Ser Ala  Gly Ser Gly 
    1970                 1975                 1980             


Pro Ala  Ala Thr Gln Asp Phe  Ser Lys Leu Leu Ser  Ser Val Lys 
    1985                 1990                 1995             


Glu Ile  Ser Asp Ile Val Gln  Arg 
    2000                 2005     


<210>  5
<211>  1530
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Ile Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Asp Glu Gly Ala Phe His Gly Asp Ala Glu Ala Leu Gln Arg Pro 
            420                 425                 430         


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        435                 440                 445             


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    450                 455                 460                 


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
465                 470                 475                 480 


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                485                 490                 495     


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            500                 505                 510         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        515                 520                 525             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Pro Leu Ser Ser Gly 
    530                 535                 540                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Ser Gln 
545                 550                 555                 560 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                565                 570                 575     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            580                 585                 590         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        595                 600                 605             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    610                 615                 620                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
625                 630                 635                 640 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val 
                645                 650                 655     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            660                 665                 670         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        675                 680                 685             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    690                 695                 700                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
705                 710                 715                 720 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                725                 730                 735     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            740                 745                 750         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        755                 760                 765             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    770                 775                 780                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
785                 790                 795                 800 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                805                 810                 815     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            820                 825                 830         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Arg Ser Gln Val 
        835                 840                 845             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Lys Arg Pro Glu Gly Cys 
    850                 855                 860                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
865                 870                 875                 880 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                885                 890                 895     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            900                 905                 910         


Gln Gly Val Arg Gly Ala Val Thr Thr Leu Leu Gln Ala Pro Glu Leu 
        915                 920                 925             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    930                 935                 940                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
945                 950                 955                 960 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                965                 970                 975     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            980                 985                 990         


Lys Asp Lys Lys Thr Asn Leu Phe  Ser Ala Leu Ile Lys  Lys Lys Lys 
        995                 1000                 1005             


Lys Thr  Ala Pro Thr Pro Pro  Lys Arg Ser Ser Ser  Phe Arg Glu 
    1010                 1015                 1020             


Met Asp  Gly Gln Pro Glu Arg  Arg Gly Ala Gly Glu  Glu Glu Gly 
    1025                 1030                 1035             


Arg Asp  Ile Ser Asn Gly Ala  Leu Ala Phe Thr Pro  Leu Asp Thr 
    1040                 1045                 1050             


Ala Asp  Pro Ala Lys Ser Pro  Lys Pro Ser Asn Gly  Ala Gly Val 
    1055                 1060                 1065             


Pro Asn  Gly Ala Leu Arg Glu  Ser Gly Gly Ser Gly  Phe Arg Ser 
    1070                 1075                 1080             


Pro His  Leu Trp Lys Lys Ser  Ser Thr Leu Thr Ser  Ser Arg Leu 
    1085                 1090                 1095             


Ala Thr  Gly Glu Glu Glu Gly  Gly Gly Ser Ser Ser  Lys Arg Phe 
    1100                 1105                 1110             


Leu Arg  Ser Cys Ser Val Ser  Cys Val Pro His Gly  Ala Lys Asp 
    1115                 1120                 1125             


Thr Glu  Trp Arg Ser Val Thr  Leu Pro Arg Asp Leu  Gln Ser Thr 
    1130                 1135                 1140             


Gly Arg  Gln Phe Asp Ser Ser  Thr Phe Gly Gly His  Lys Ser Glu 
    1145                 1150                 1155             


Lys Pro  Ala Leu Pro Arg Lys  Arg Ala Gly Glu Asn  Arg Ser Asp 
    1160                 1165                 1170             


Gln Val  Thr Arg Gly Thr Val  Thr Pro Pro Pro Arg  Leu Val Lys 
    1175                 1180                 1185             


Lys Asn  Glu Glu Ala Ala Asp  Glu Val Phe Lys Asp  Ile Met Glu 
    1190                 1195                 1200             


Ser Ser  Pro Gly Ser Ser Pro  Pro Asn Leu Thr Pro  Lys Pro Leu 
    1205                 1210                 1215             


Arg Arg  Gln Val Thr Val Ala  Pro Ala Ser Gly Leu  Pro His Lys 
    1220                 1225                 1230             


Glu Glu  Ala Trp Lys Gly Ser  Ala Leu Gly Thr Pro  Ala Ala Ala 
    1235                 1240                 1245             


Glu Pro  Val Thr Pro Thr Ser  Lys Ala Gly Ser Gly  Ala Pro Arg 
    1250                 1255                 1260             


Gly Thr  Ser Lys Gly Pro Ala  Glu Glu Ser Arg Val  Arg Arg His 
    1265                 1270                 1275             


Lys His  Ser Ser Glu Ser Pro  Gly Arg Asp Lys Gly  Lys Leu Ser 
    1280                 1285                 1290             


Lys Leu  Lys Pro Ala Pro Pro  Pro Pro Pro Ala Ala  Ser Ala Gly 
    1295                 1300                 1305             


Lys Ala  Gly Gly Lys Pro Ser  Gln Arg Pro Gly Gln  Glu Ala Ala 
    1310                 1315                 1320             


Gly Glu  Ala Val Leu Gly Ala  Lys Thr Lys Ala Thr  Ser Leu Val 
    1325                 1330                 1335             


Asp Ala  Val Asn Ser Asp Ala  Ala Lys Pro Ser Gln  Pro Ala Glu 
    1340                 1345                 1350             


Gly Leu  Lys Lys Pro Val Leu  Pro Ala Thr Pro Lys  Pro His Pro 
    1355                 1360                 1365             


Ala Lys  Pro Ser Gly Thr Pro  Ile Ser Pro Ala Pro  Val Pro Leu 
    1370                 1375                 1380             


Ser Thr  Leu Pro Ser Ala Ser  Ser Ala Leu Ala Gly  Asp Gln Pro 
    1385                 1390                 1395             


Ser Ser  Thr Ala Phe Ile Pro  Leu Ile Ser Thr Arg  Val Ser Leu 
    1400                 1405                 1410             


Arg Lys  Thr Arg Gln Pro Pro  Glu Arg Ala Ser Gly  Ala Ile Thr 
    1415                 1420                 1425             


Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala Leu Cys  Leu Ala Ile 
    1430                 1435                 1440             


Ser Gly  Asn Ser Glu Gln Met  Ala Ser His Ser Ala  Val Leu Glu 
    1445                 1450                 1455             


Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val Ser Tyr  Val Asp Ser 
    1460                 1465                 1470             


Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe Arg Glu  Ala Ile Asn 
    1475                 1480                 1485             


Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln Ile Cys  Pro Ala Ser 
    1490                 1495                 1500             


Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp Phe Ser  Lys Leu Leu 
    1505                 1510                 1515             


Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val Gln Arg  
    1520                 1525                 1530 


<210>  6
<211>  2031
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Ile Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Asp Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Lys Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        515                 520                 525             


Ala Ala Ala Thr Thr Ser Gln Pro Val Leu Thr Ser Gln Gln Ile Glu 
    530                 535                 540                 


Thr Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Ser 
545                 550                 555                 560 


Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 
                565                 570                 575     


Val Gly Asp Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Arg 
            580                 585                 590         


Ala Phe Val Asp Asn Tyr Gly Val Ala Met Glu Met Ala Glu Lys Cys 
        595                 600                 605             


Cys Gln Ala Asn Ala Gln Phe Ala Glu Ile Ser Glu Asn Leu Arg Ala 
    610                 615                 620                 


Arg Ser Asn Lys Asp Ala Lys Asp Pro Thr Thr Lys Asn Ser Leu Glu 
625                 630                 635                 640 


Thr Leu Leu Tyr Lys Pro Val Asp Arg Val Thr Arg Ser Thr Leu Val 
                645                 650                 655     


Leu His Asp Leu Leu Lys His Thr Pro Ala Ser His Pro Asp His Pro 
            660                 665                 670         


Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile 
        675                 680                 685             


Asn Glu Glu Ile Thr Pro Arg Arg Gln Ser Met Thr Val Lys Lys Gly 
    690                 695                 700                 


Glu His Arg Gln Leu Leu Lys Asp Ser Phe Met Val Glu Leu Val Glu 
705                 710                 715                 720 


Gly Ala Arg Lys Leu Arg His Val Phe Leu Phe Thr Asp Leu Leu Leu 
                725                 730                 735     


Cys Thr Lys Leu Lys Lys Gln Ser Gly Gly Lys Thr Gln Gln Tyr Asp 
            740                 745                 750         


Cys Lys Trp Tyr Ile Pro Leu Thr Asp Leu Ser Phe Gln Met Val Asp 
        755                 760                 765             


Glu Leu Glu Ala Val Pro Asn Ile Pro Leu Val Pro Asp Glu Glu Leu 
    770                 775                 780                 


Asp Ala Leu Lys Ile Lys Ile Ser Gln Ile Lys Ser Asp Ile Gln Arg 
785                 790                 795                 800 


Glu Lys Arg Ala Asn Lys Gly Ser Lys Ala Thr Glu Arg Leu Lys Lys 
                805                 810                 815     


Lys Leu Ser Glu Gln Glu Ser Leu Leu Leu Leu Met Ser Pro Ser Met 
            820                 825                 830         


Ala Phe Arg Val His Ser Arg Asn Gly Lys Ser Tyr Thr Phe Leu Ile 
        835                 840                 845             


Ser Ser Asp Tyr Glu Arg Ala Glu Trp Arg Glu Asn Ile Arg Glu Gln 
    850                 855                 860                 


Gln Lys Lys Cys Phe Arg Ser Phe Ser Leu Thr Ser Val Glu Leu Gln 
865                 870                 875                 880 


Met Leu Thr Asn Ser Cys Val Lys Leu Gln Thr Val His Ser Ile Pro 
                885                 890                 895     


Leu Thr Ile Asn Lys Glu Asp Asp Glu Ser Pro Gly Leu Tyr Gly Phe 
            900                 905                 910         


Leu Asn Val Ile Val His Ser Ala Thr Gly Phe Lys Gln Ser Ser Lys 
        915                 920                 925             


Ala Leu Gln Arg Pro Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser 
    930                 935                 940                 


Glu Ala Ala Arg Trp Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser 
945                 950                 955                 960 


Glu Asn Asp Pro Asn Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser 
                965                 970                 975     


Gly Asp Asn Thr Leu Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu 
            980                 985                 990         


Gly Tyr Asn His Asn Gly Glu Trp  Cys Glu Ala Gln Thr  Lys Asn Gly 
        995                 1000                 1005             


Gln Gly  Trp Val Pro Ser Asn  Tyr Ile Thr Pro Val  Asn Ser Leu 
    1010                 1015                 1020             


Glu Lys  His Ser Trp Tyr His  Gly Pro Val Ser Arg  Asn Ala Ala 
    1025                 1030                 1035             


Glu Tyr  Pro Leu Ser Ser Gly  Ile Asn Gly Ser Phe  Leu Val Arg 
    1040                 1045                 1050             


Glu Ser  Glu Ser Ser Pro Ser  Gln Arg Ser Ile Ser  Leu Arg Tyr 
    1055                 1060                 1065             


Glu Gly  Arg Val Tyr His Tyr  Arg Ile Asn Thr Ala  Ser Asp Gly 
    1070                 1075                 1080             


Lys Leu  Tyr Val Ser Ser Glu  Ser Arg Phe Asn Thr  Leu Ala Glu 
    1085                 1090                 1095             


Leu Val  His His His Ser Thr  Val Ala Asp Gly Leu  Ile Thr Thr 
    1100                 1105                 1110             


Leu His  Tyr Pro Ala Pro Lys  Arg Asn Lys Pro Thr  Val Tyr Gly 
    1115                 1120                 1125             


Val Ser  Pro Asn Tyr Asp Lys  Trp Glu Met Glu Arg  Thr Asp Ile 
    1130                 1135                 1140             


Thr Met  Lys His Lys Leu Gly  Gly Gly Gln Tyr Gly  Glu Val Tyr 
    1145                 1150                 1155             


Glu Gly  Val Trp Lys Lys Tyr  Ser Leu Thr Val Ala  Val Lys Thr 
    1160                 1165                 1170             


Leu Lys  Glu Asp Thr Met Glu  Val Glu Glu Phe Leu  Lys Glu Ala 
    1175                 1180                 1185             


Ala Val  Met Lys Glu Ile Lys  His Pro Asn Leu Val  Gln Leu Leu 
    1190                 1195                 1200             


Gly Val  Cys Thr Arg Glu Pro  Pro Phe Tyr Ile Ile  Ile Glu Phe 
    1205                 1210                 1215             


Met Thr  Tyr Gly Asn Leu Leu  Asp Tyr Leu Arg Glu  Cys Asn Arg 
    1220                 1225                 1230             


Gln Glu  Val Asn Ala Val Val  Leu Leu Tyr Met Ala  Thr Gln Ile 
    1235                 1240                 1245             


Ser Ser  Ala Met Glu Tyr Leu  Glu Lys Lys Asn Phe  Ile His Arg 
    1250                 1255                 1260             


Asp Leu  Ala Ala Arg Asn Cys  Leu Val Gly Glu Asn  His Leu Val 
    1265                 1270                 1275             


Lys Val  Ala Asp Phe Gly Leu  Ser Arg Leu Met Thr  Gly Asp Thr 
    1280                 1285                 1290             


Tyr Thr  Ala His Ala Gly Ala  Lys Phe Pro Ile Lys  Trp Thr Ala 
    1295                 1300                 1305             


Pro Glu  Ser Leu Ala Tyr Asn  Lys Phe Ser Ile Lys  Ser Asp Val 
    1310                 1315                 1320             


Trp Ala  Phe Gly Val Leu Leu  Trp Glu Ile Ala Thr  Tyr Gly Met 
    1325                 1330                 1335             


Ser Pro  Tyr Pro Gly Ile Asp  Arg Ser Gln Val Tyr  Glu Leu Leu 
    1340                 1345                 1350             


Glu Lys  Asp Tyr Arg Met Lys  Arg Pro Glu Gly Cys  Pro Glu Lys 
    1355                 1360                 1365             


Val Tyr  Glu Leu Met Arg Ala  Cys Trp Gln Trp Asn  Pro Ser Asp 
    1370                 1375                 1380             


Arg Pro  Ser Phe Ala Glu Ile  His Gln Ala Phe Glu  Thr Met Phe 
    1385                 1390                 1395             


Gln Glu  Ser Ser Ile Ser Asp  Glu Val Glu Lys Glu  Leu Gly Lys 
    1400                 1405                 1410             


Gln Gly  Val Arg Gly Ala Val  Thr Thr Leu Leu Gln  Ala Pro Glu 
    1415                 1420                 1425             


Leu Pro  Thr Lys Thr Arg Thr  Ser Arg Arg Ala Ala  Glu His Arg 
    1430                 1435                 1440             


Asp Thr  Thr Asp Val Pro Glu  Met Pro His Ser Lys  Gly Gln Gly 
    1445                 1450                 1455             


Glu Ser  Asp Pro Leu Asp His  Glu Pro Ala Val Ser  Pro Leu Leu 
    1460                 1465                 1470             


Pro Arg  Lys Glu Arg Gly Pro  Pro Glu Gly Gly Leu  Asn Glu Asp 
    1475                 1480                 1485             


Glu Arg  Leu Leu Pro Lys Asp  Lys Lys Thr Asn Leu  Phe Ser Ala 
    1490                 1495                 1500             


Leu Ile  Lys Lys Lys Lys Lys  Thr Ala Pro Thr Pro  Pro Lys Arg 
    1505                 1510                 1515             


Ser Ser  Ser Phe Arg Glu Met  Asp Gly Gln Pro Glu  Arg Arg Gly 
    1520                 1525                 1530             


Ala Gly  Glu Glu Glu Gly Arg  Asp Ile Ser Asn Gly  Ala Leu Ala 
    1535                 1540                 1545             


Phe Thr  Pro Leu Asp Thr Ala  Asp Pro Ala Lys Ser  Pro Lys Pro 
    1550                 1555                 1560             


Ser Asn  Gly Ala Gly Val Pro  Asn Gly Ala Leu Arg  Glu Ser Gly 
    1565                 1570                 1575             


Gly Ser  Gly Phe Arg Ser Pro  His Leu Trp Lys Lys  Ser Ser Thr 
    1580                 1585                 1590             


Leu Thr  Ser Ser Arg Leu Ala  Thr Gly Glu Glu Glu  Gly Gly Gly 
    1595                 1600                 1605             


Ser Ser  Ser Lys Arg Phe Leu  Arg Ser Cys Ser Val  Ser Cys Val 
    1610                 1615                 1620             


Pro His  Gly Ala Lys Asp Thr  Glu Trp Arg Ser Val  Thr Leu Pro 
    1625                 1630                 1635             


Arg Asp  Leu Gln Ser Thr Gly  Arg Gln Phe Asp Ser  Ser Thr Phe 
    1640                 1645                 1650             


Gly Gly  His Lys Ser Glu Lys  Pro Ala Leu Pro Arg  Lys Arg Ala 
    1655                 1660                 1665             


Gly Glu  Asn Arg Ser Asp Gln  Val Thr Arg Gly Thr  Val Thr Pro 
    1670                 1675                 1680             


Pro Pro  Arg Leu Val Lys Lys  Asn Glu Glu Ala Ala  Asp Glu Val 
    1685                 1690                 1695             


Phe Lys  Asp Ile Met Glu Ser  Ser Pro Gly Ser Ser  Pro Pro Asn 
    1700                 1705                 1710             


Leu Thr  Pro Lys Pro Leu Arg  Arg Gln Val Thr Val  Ala Pro Ala 
    1715                 1720                 1725             


Ser Gly  Leu Pro His Lys Glu  Glu Ala Trp Lys Gly  Ser Ala Leu 
    1730                 1735                 1740             


Gly Thr  Pro Ala Ala Ala Glu  Pro Val Thr Pro Thr  Ser Lys Ala 
    1745                 1750                 1755             


Gly Ser  Gly Ala Pro Arg Gly  Thr Ser Lys Gly Pro  Ala Glu Glu 
    1760                 1765                 1770             


Ser Arg  Val Arg Arg His Lys  His Ser Ser Glu Ser  Pro Gly Arg 
    1775                 1780                 1785             


Asp Lys  Gly Lys Leu Ser Lys  Leu Lys Pro Ala Pro  Pro Pro Pro 
    1790                 1795                 1800             


Pro Ala  Ala Ser Ala Gly Lys  Ala Gly Gly Lys Pro  Ser Gln Arg 
    1805                 1810                 1815             


Pro Gly  Gln Glu Ala Ala Gly  Glu Ala Val Leu Gly  Ala Lys Thr 
    1820                 1825                 1830             


Lys Ala  Thr Ser Leu Val Asp  Ala Val Asn Ser Asp  Ala Ala Lys 
    1835                 1840                 1845             


Pro Ser  Gln Pro Ala Glu Gly  Leu Lys Lys Pro Val  Leu Pro Ala 
    1850                 1855                 1860             


Thr Pro  Lys Pro His Pro Ala  Lys Pro Ser Gly Thr  Pro Ile Ser 
    1865                 1870                 1875             


Pro Ala  Pro Val Pro Leu Ser  Thr Leu Pro Ser Ala  Ser Ser Ala 
    1880                 1885                 1890             


Leu Ala  Gly Asp Gln Pro Ser  Ser Thr Ala Phe Ile  Pro Leu Ile 
    1895                 1900                 1905             


Ser Thr  Arg Val Ser Leu Arg  Lys Thr Arg Gln Pro  Pro Glu Arg 
    1910                 1915                 1920             


Ala Ser  Gly Ala Ile Thr Lys  Gly Val Val Leu Asp  Ser Thr Glu 
    1925                 1930                 1935             


Ala Leu  Cys Leu Ala Ile Ser  Gly Asn Ser Glu Gln  Met Ala Ser 
    1940                 1945                 1950             


His Ser  Ala Val Leu Glu Ala  Gly Lys Asn Leu Tyr  Thr Phe Cys 
    1955                 1960                 1965             


Val Ser  Tyr Val Asp Ser Ile  Gln Gln Met Arg Asn  Lys Phe Ala 
    1970                 1975                 1980             


Phe Arg  Glu Ala Ile Asn Lys  Leu Glu Asn Asn Leu  Arg Glu Leu 
    1985                 1990                 1995             


Gln Ile  Cys Pro Ala Ser Ala  Gly Ser Gly Pro Ala  Ala Thr Gln 
    2000                 2005                 2010             


Asp Phe  Ser Lys Leu Leu Ser  Ser Val Lys Glu Ile  Ser Asp Ile 
    2015                 2020                 2025             


Val Gln  Arg 
    2030     


<210>  7
<211>  2006
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Ile Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Asp Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Lys Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        515                 520                 525             


Ala Ala Ala Thr Thr Ser Gln Pro Val Leu Thr Ser Gln Gln Ile Glu 
    530                 535                 540                 


Thr Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Ser 
545                 550                 555                 560 


Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 
                565                 570                 575     


Val Gly Asp Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Arg 
            580                 585                 590         


Ala Phe Val Asp Asn Tyr Gly Val Ala Met Glu Met Ala Glu Lys Cys 
        595                 600                 605             


Cys Gln Ala Asn Ala Gln Phe Ala Glu Ile Ser Glu Asn Leu Arg Ala 
    610                 615                 620                 


Arg Ser Asn Lys Asp Ala Lys Asp Pro Thr Thr Lys Asn Ser Leu Glu 
625                 630                 635                 640 


Thr Leu Leu Tyr Lys Pro Val Asp Arg Val Thr Arg Ser Thr Leu Val 
                645                 650                 655     


Leu His Asp Leu Leu Lys His Thr Pro Ala Ser His Pro Asp His Pro 
            660                 665                 670         


Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile 
        675                 680                 685             


Asn Glu Glu Ile Thr Pro Arg Arg Gln Ser Met Thr Val Lys Lys Gly 
    690                 695                 700                 


Glu His Arg Gln Leu Leu Lys Asp Ser Phe Met Val Glu Leu Val Glu 
705                 710                 715                 720 


Gly Ala Arg Lys Leu Arg His Val Phe Leu Phe Thr Asp Leu Leu Leu 
                725                 730                 735     


Cys Thr Lys Leu Lys Lys Gln Ser Gly Gly Lys Thr Gln Gln Tyr Asp 
            740                 745                 750         


Cys Lys Trp Tyr Ile Pro Leu Thr Asp Leu Ser Phe Gln Met Val Asp 
        755                 760                 765             


Glu Leu Glu Ala Val Pro Asn Ile Pro Leu Val Pro Asp Glu Glu Leu 
    770                 775                 780                 


Asp Ala Leu Lys Ile Lys Ile Ser Gln Ile Lys Ser Asp Ile Gln Arg 
785                 790                 795                 800 


Glu Lys Arg Ala Asn Lys Gly Ser Lys Ala Thr Glu Arg Leu Lys Lys 
                805                 810                 815     


Lys Leu Ser Glu Gln Glu Ser Leu Leu Leu Leu Met Ser Pro Ser Met 
            820                 825                 830         


Ala Phe Arg Val His Ser Arg Asn Gly Lys Ser Tyr Thr Phe Leu Ile 
        835                 840                 845             


Ser Ser Asp Tyr Glu Arg Ala Glu Trp Arg Glu Asn Ile Arg Glu Gln 
    850                 855                 860                 


Gln Lys Lys Cys Phe Arg Ser Phe Ser Leu Thr Ser Val Glu Leu Gln 
865                 870                 875                 880 


Met Leu Thr Asn Ser Cys Val Lys Leu Gln Thr Val His Ser Ile Pro 
                885                 890                 895     


Leu Thr Ile Asn Lys Glu Glu Ala Leu Gln Arg Pro Val Ala Ser Asp 
            900                 905                 910         


Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp Asn Ser Lys Glu 
        915                 920                 925             


Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn Leu Phe Val Ala 
    930                 935                 940                 


Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu Ser Ile Thr Lys 
945                 950                 955                 960 


Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn Gly Glu Trp Cys 
                965                 970                 975     


Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro Ser Asn Tyr Ile 
            980                 985                 990         


Thr Pro Val Asn Ser Leu Glu Lys  His Ser Trp Tyr His  Gly Pro Val 
        995                 1000                 1005             


Ser Arg  Asn Ala Ala Glu Tyr  Pro Leu Ser Ser Gly  Ile Asn Gly 
    1010                 1015                 1020             


Ser Phe  Leu Val Arg Glu Ser  Glu Ser Ser Pro Ser  Gln Arg Ser 
    1025                 1030                 1035             


Ile Ser  Leu Arg Tyr Glu Gly  Arg Val Tyr His Tyr  Arg Ile Asn 
    1040                 1045                 1050             


Thr Ala  Ser Asp Gly Lys Leu  Tyr Val Ser Ser Glu  Ser Arg Phe 
    1055                 1060                 1065             


Asn Thr  Leu Ala Glu Leu Val  His His His Ser Thr  Val Ala Asp 
    1070                 1075                 1080             


Gly Leu  Ile Thr Thr Leu His  Tyr Pro Ala Pro Lys  Arg Asn Lys 
    1085                 1090                 1095             


Pro Thr  Val Tyr Gly Val Ser  Pro Asn Tyr Asp Lys  Trp Glu Met 
    1100                 1105                 1110             


Glu Arg  Thr Asp Ile Thr Met  Lys His Lys Leu Gly  Gly Gly Gln 
    1115                 1120                 1125             


Tyr Gly  Glu Val Tyr Glu Gly  Val Trp Lys Lys Tyr  Ser Leu Thr 
    1130                 1135                 1140             


Val Ala  Val Lys Thr Leu Lys  Glu Asp Thr Met Glu  Val Glu Glu 
    1145                 1150                 1155             


Phe Leu  Lys Glu Ala Ala Val  Met Lys Glu Ile Lys  His Pro Asn 
    1160                 1165                 1170             


Leu Val  Gln Leu Leu Gly Val  Cys Thr Arg Glu Pro  Pro Phe Tyr 
    1175                 1180                 1185             


Ile Ile  Ile Glu Phe Met Thr  Tyr Gly Asn Leu Leu  Asp Tyr Leu 
    1190                 1195                 1200             


Arg Glu  Cys Asn Arg Gln Glu  Val Asn Ala Val Val  Leu Leu Tyr 
    1205                 1210                 1215             


Met Ala  Thr Gln Ile Ser Ser  Ala Met Glu Tyr Leu  Glu Lys Lys 
    1220                 1225                 1230             


Asn Phe  Ile His Arg Asp Leu  Ala Ala Arg Asn Cys  Leu Val Gly 
    1235                 1240                 1245             


Glu Asn  His Leu Val Lys Val  Ala Asp Phe Gly Leu  Ser Arg Leu 
    1250                 1255                 1260             


Met Thr  Gly Asp Thr Tyr Thr  Ala His Ala Gly Ala  Lys Phe Pro 
    1265                 1270                 1275             


Ile Lys  Trp Thr Ala Pro Glu  Ser Leu Ala Tyr Asn  Lys Phe Ser 
    1280                 1285                 1290             


Ile Lys  Ser Asp Val Trp Ala  Phe Gly Val Leu Leu  Trp Glu Ile 
    1295                 1300                 1305             


Ala Thr  Tyr Gly Met Ser Pro  Tyr Pro Gly Ile Asp  Arg Ser Gln 
    1310                 1315                 1320             


Val Tyr  Glu Leu Leu Glu Lys  Asp Tyr Arg Met Lys  Arg Pro Glu 
    1325                 1330                 1335             


Gly Cys  Pro Glu Lys Val Tyr  Glu Leu Met Arg Ala  Cys Trp Gln 
    1340                 1345                 1350             


Trp Asn  Pro Ser Asp Arg Pro  Ser Phe Ala Glu Ile  His Gln Ala 
    1355                 1360                 1365             


Phe Glu  Thr Met Phe Gln Glu  Ser Ser Ile Ser Asp  Glu Val Glu 
    1370                 1375                 1380             


Lys Glu  Leu Gly Lys Gln Gly  Val Arg Gly Ala Val  Thr Thr Leu 
    1385                 1390                 1395             


Leu Gln  Ala Pro Glu Leu Pro  Thr Lys Thr Arg Thr  Ser Arg Arg 
    1400                 1405                 1410             


Ala Ala  Glu His Arg Asp Thr  Thr Asp Val Pro Glu  Met Pro His 
    1415                 1420                 1425             


Ser Lys  Gly Gln Gly Glu Ser  Asp Pro Leu Asp His  Glu Pro Ala 
    1430                 1435                 1440             


Val Ser  Pro Leu Leu Pro Arg  Lys Glu Arg Gly Pro  Pro Glu Gly 
    1445                 1450                 1455             


Gly Leu  Asn Glu Asp Glu Arg  Leu Leu Pro Lys Asp  Lys Lys Thr 
    1460                 1465                 1470             


Asn Leu  Phe Ser Ala Leu Ile  Lys Lys Lys Lys Lys  Thr Ala Pro 
    1475                 1480                 1485             


Thr Pro  Pro Lys Arg Ser Ser  Ser Phe Arg Glu Met  Asp Gly Gln 
    1490                 1495                 1500             


Pro Glu  Arg Arg Gly Ala Gly  Glu Glu Glu Gly Arg  Asp Ile Ser 
    1505                 1510                 1515             


Asn Gly  Ala Leu Ala Phe Thr  Pro Leu Asp Thr Ala  Asp Pro Ala 
    1520                 1525                 1530             


Lys Ser  Pro Lys Pro Ser Asn  Gly Ala Gly Val Pro  Asn Gly Ala 
    1535                 1540                 1545             


Leu Arg  Glu Ser Gly Gly Ser  Gly Phe Arg Ser Pro  His Leu Trp 
    1550                 1555                 1560             


Lys Lys  Ser Ser Thr Leu Thr  Ser Ser Arg Leu Ala  Thr Gly Glu 
    1565                 1570                 1575             


Glu Glu  Gly Gly Gly Ser Ser  Ser Lys Arg Phe Leu  Arg Ser Cys 
    1580                 1585                 1590             


Ser Val  Ser Cys Val Pro His  Gly Ala Lys Asp Thr  Glu Trp Arg 
    1595                 1600                 1605             


Ser Val  Thr Leu Pro Arg Asp  Leu Gln Ser Thr Gly  Arg Gln Phe 
    1610                 1615                 1620             


Asp Ser  Ser Thr Phe Gly Gly  His Lys Ser Glu Lys  Pro Ala Leu 
    1625                 1630                 1635             


Pro Arg  Lys Arg Ala Gly Glu  Asn Arg Ser Asp Gln  Val Thr Arg 
    1640                 1645                 1650             


Gly Thr  Val Thr Pro Pro Pro  Arg Leu Val Lys Lys  Asn Glu Glu 
    1655                 1660                 1665             


Ala Ala  Asp Glu Val Phe Lys  Asp Ile Met Glu Ser  Ser Pro Gly 
    1670                 1675                 1680             


Ser Ser  Pro Pro Asn Leu Thr  Pro Lys Pro Leu Arg  Arg Gln Val 
    1685                 1690                 1695             


Thr Val  Ala Pro Ala Ser Gly  Leu Pro His Lys Glu  Glu Ala Trp 
    1700                 1705                 1710             


Lys Gly  Ser Ala Leu Gly Thr  Pro Ala Ala Ala Glu  Pro Val Thr 
    1715                 1720                 1725             


Pro Thr  Ser Lys Ala Gly Ser  Gly Ala Pro Arg Gly  Thr Ser Lys 
    1730                 1735                 1740             


Gly Pro  Ala Glu Glu Ser Arg  Val Arg Arg His Lys  His Ser Ser 
    1745                 1750                 1755             


Glu Ser  Pro Gly Arg Asp Lys  Gly Lys Leu Ser Lys  Leu Lys Pro 
    1760                 1765                 1770             


Ala Pro  Pro Pro Pro Pro Ala  Ala Ser Ala Gly Lys  Ala Gly Gly 
    1775                 1780                 1785             


Lys Pro  Ser Gln Arg Pro Gly  Gln Glu Ala Ala Gly  Glu Ala Val 
    1790                 1795                 1800             


Leu Gly  Ala Lys Thr Lys Ala  Thr Ser Leu Val Asp  Ala Val Asn 
    1805                 1810                 1815             


Ser Asp  Ala Ala Lys Pro Ser  Gln Pro Ala Glu Gly  Leu Lys Lys 
    1820                 1825                 1830             


Pro Val  Leu Pro Ala Thr Pro  Lys Pro His Pro Ala  Lys Pro Ser 
    1835                 1840                 1845             


Gly Thr  Pro Ile Ser Pro Ala  Pro Val Pro Leu Ser  Thr Leu Pro 
    1850                 1855                 1860             


Ser Ala  Ser Ser Ala Leu Ala  Gly Asp Gln Pro Ser  Ser Thr Ala 
    1865                 1870                 1875             


Phe Ile  Pro Leu Ile Ser Thr  Arg Val Ser Leu Arg  Lys Thr Arg 
    1880                 1885                 1890             


Gln Pro  Pro Glu Arg Ala Ser  Gly Ala Ile Thr Lys  Gly Val Val 
    1895                 1900                 1905             


Leu Asp  Ser Thr Glu Ala Leu  Cys Leu Ala Ile Ser  Gly Asn Ser 
    1910                 1915                 1920             


Glu Gln  Met Ala Ser His Ser  Ala Val Leu Glu Ala  Gly Lys Asn 
    1925                 1930                 1935             


Leu Tyr  Thr Phe Cys Val Ser  Tyr Val Asp Ser Ile  Gln Gln Met 
    1940                 1945                 1950             


Arg Asn  Lys Phe Ala Phe Arg  Glu Ala Ile Asn Lys  Leu Glu Asn 
    1955                 1960                 1965             


Asn Leu  Arg Glu Leu Gln Ile  Cys Pro Ala Ser Ala  Gly Ser Gly 
    1970                 1975                 1980             


Pro Ala  Ala Thr Gln Asp Phe  Ser Lys Leu Leu Ser  Ser Val Lys 
    1985                 1990                 1995             


Glu Ile  Ser Asp Ile Val Gln  Arg 
    2000                 2005     


<210>  8
<211>  1530
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Ile Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Asp Glu Gly Ala Phe His Gly Asp Ala Glu Ala Leu Gln Arg Pro 
            420                 425                 430         


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        435                 440                 445             


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    450                 455                 460                 


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
465                 470                 475                 480 


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                485                 490                 495     


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            500                 505                 510         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        515                 520                 525             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Pro Leu Ser Ser Gly 
    530                 535                 540                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Ser Gln 
545                 550                 555                 560 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                565                 570                 575     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            580                 585                 590         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        595                 600                 605             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    610                 615                 620                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
625                 630                 635                 640 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val 
                645                 650                 655     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            660                 665                 670         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        675                 680                 685             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    690                 695                 700                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Ile Glu Phe Met Thr Tyr 
705                 710                 715                 720 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                725                 730                 735     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            740                 745                 750         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        755                 760                 765             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    770                 775                 780                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
785                 790                 795                 800 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                805                 810                 815     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            820                 825                 830         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Arg Ser Gln Val 
        835                 840                 845             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Lys Arg Pro Glu Gly Cys 
    850                 855                 860                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
865                 870                 875                 880 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                885                 890                 895     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            900                 905                 910         


Gln Gly Val Arg Gly Ala Val Thr Thr Leu Leu Gln Ala Pro Glu Leu 
        915                 920                 925             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    930                 935                 940                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
945                 950                 955                 960 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                965                 970                 975     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            980                 985                 990         


Lys Asp Lys Lys Thr Asn Leu Phe  Ser Ala Leu Ile Lys  Lys Lys Lys 
        995                 1000                 1005             


Lys Thr  Ala Pro Thr Pro Pro  Lys Arg Ser Ser Ser  Phe Arg Glu 
    1010                 1015                 1020             


Met Asp  Gly Gln Pro Glu Arg  Arg Gly Ala Gly Glu  Glu Glu Gly 
    1025                 1030                 1035             


Arg Asp  Ile Ser Asn Gly Ala  Leu Ala Phe Thr Pro  Leu Asp Thr 
    1040                 1045                 1050             


Ala Asp  Pro Ala Lys Ser Pro  Lys Pro Ser Asn Gly  Ala Gly Val 
    1055                 1060                 1065             


Pro Asn  Gly Ala Leu Arg Glu  Ser Gly Gly Ser Gly  Phe Arg Ser 
    1070                 1075                 1080             


Pro His  Leu Trp Lys Lys Ser  Ser Thr Leu Thr Ser  Ser Arg Leu 
    1085                 1090                 1095             


Ala Thr  Gly Glu Glu Glu Gly  Gly Gly Ser Ser Ser  Lys Arg Phe 
    1100                 1105                 1110             


Leu Arg  Ser Cys Ser Val Ser  Cys Val Pro His Gly  Ala Lys Asp 
    1115                 1120                 1125             


Thr Glu  Trp Arg Ser Val Thr  Leu Pro Arg Asp Leu  Gln Ser Thr 
    1130                 1135                 1140             


Gly Arg  Gln Phe Asp Ser Ser  Thr Phe Gly Gly His  Lys Ser Glu 
    1145                 1150                 1155             


Lys Pro  Ala Leu Pro Arg Lys  Arg Ala Gly Glu Asn  Arg Ser Asp 
    1160                 1165                 1170             


Gln Val  Thr Arg Gly Thr Val  Thr Pro Pro Pro Arg  Leu Val Lys 
    1175                 1180                 1185             


Lys Asn  Glu Glu Ala Ala Asp  Glu Val Phe Lys Asp  Ile Met Glu 
    1190                 1195                 1200             


Ser Ser  Pro Gly Ser Ser Pro  Pro Asn Leu Thr Pro  Lys Pro Leu 
    1205                 1210                 1215             


Arg Arg  Gln Val Thr Val Ala  Pro Ala Ser Gly Leu  Pro His Lys 
    1220                 1225                 1230             


Glu Glu  Ala Trp Lys Gly Ser  Ala Leu Gly Thr Pro  Ala Ala Ala 
    1235                 1240                 1245             


Glu Pro  Val Thr Pro Thr Ser  Lys Ala Gly Ser Gly  Ala Pro Arg 
    1250                 1255                 1260             


Gly Thr  Ser Lys Gly Pro Ala  Glu Glu Ser Arg Val  Arg Arg His 
    1265                 1270                 1275             


Lys His  Ser Ser Glu Ser Pro  Gly Arg Asp Lys Gly  Lys Leu Ser 
    1280                 1285                 1290             


Lys Leu  Lys Pro Ala Pro Pro  Pro Pro Pro Ala Ala  Ser Ala Gly 
    1295                 1300                 1305             


Lys Ala  Gly Gly Lys Pro Ser  Gln Arg Pro Gly Gln  Glu Ala Ala 
    1310                 1315                 1320             


Gly Glu  Ala Val Leu Gly Ala  Lys Thr Lys Ala Thr  Ser Leu Val 
    1325                 1330                 1335             


Asp Ala  Val Asn Ser Asp Ala  Ala Lys Pro Ser Gln  Pro Ala Glu 
    1340                 1345                 1350             


Gly Leu  Lys Lys Pro Val Leu  Pro Ala Thr Pro Lys  Pro His Pro 
    1355                 1360                 1365             


Ala Lys  Pro Ser Gly Thr Pro  Ile Ser Pro Ala Pro  Val Pro Leu 
    1370                 1375                 1380             


Ser Thr  Leu Pro Ser Ala Ser  Ser Ala Leu Ala Gly  Asp Gln Pro 
    1385                 1390                 1395             


Ser Ser  Thr Ala Phe Ile Pro  Leu Ile Ser Thr Arg  Val Ser Leu 
    1400                 1405                 1410             


Arg Lys  Thr Arg Gln Pro Pro  Glu Arg Ala Ser Gly  Ala Ile Thr 
    1415                 1420                 1425             


Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala Leu Cys  Leu Ala Ile 
    1430                 1435                 1440             


Ser Gly  Asn Ser Glu Gln Met  Ala Ser His Ser Ala  Val Leu Glu 
    1445                 1450                 1455             


Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val Ser Tyr  Val Asp Ser 
    1460                 1465                 1470             


Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe Arg Glu  Ala Ile Asn 
    1475                 1480                 1485             


Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln Ile Cys  Pro Ala Ser 
    1490                 1495                 1500             


Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp Phe Ser  Lys Leu Leu 
    1505                 1510                 1515             


Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val Gln Arg  
    1520                 1525                 1530 


<210>  9
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  9

Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro Thr Arg Leu Leu 
1               5                   10                  15      


Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu Tyr Glu Arg Asp 
            20                  25                  30          


Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu Gly Leu Glu Phe 
        35                  40                  45              


Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys Leu Thr Gln Ser 
    50                  55                  60                  


Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn Met Leu Gly Gly 
65                  70                  75                  80  


Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu Gly Ala Val Asp 
                85                  90                  95      


Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser Lys Asp Phe Glu Thr 
            100                 105                 110         


Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu Met Leu Lys Met Phe 
        115                 120                 125             


Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn Gly Asp His Val Thr 
    130                 135                 140                 


His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp Val Val Leu Tyr Met 
145                 150                 155                 160 


Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu Val Cys Phe Lys Lys 
                165                 170                 175     


Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr Leu Lys Ser Ser Lys 
            180                 185                 190         


Tyr Ile Trp Pro Leu Gln Gly Trp Gln Ala Thr Phe Gly Gly Gly Asp 
        195                 200                 205             


His Pro Pro Lys Ser Asp Leu Val Pro Arg His Asn Gln Thr Ser Leu 
    210                 215                 220                 


Tyr Lys Lys Ala Gly Ser Ala Ala Ala Val Leu Glu Glu Asn Leu Tyr 
225                 230                 235                 240 


Phe Gln Gly Thr Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln 
                245                 250                 255     


Trp Lys Val Val Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp 
            260                 265                 270         


Pro Thr Gln Leu Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg 
        275                 280                 285             


Leu Ser Phe Gly Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val 
    290                 295                 300                 


Glu Ala Thr Ala Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val 
305                 310                 315                 320 


Ala Val Lys Met Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala 
                325                 330                 335     


Leu Met Ser Glu Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn 
            340                 345                 350         


Ile Val Asn Leu Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val 
        355                 360                 365             


Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg 
    370                 375                 380                 


Lys Arg Asp Ser Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala 
385                 390                 395                 400 


Ala Leu Tyr Lys Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp 
                405                 410                 415     


Ser Thr Asn Glu Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val 
            420                 425                 430         


Pro Thr Lys Ala Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile 
        435                 440                 445             


Glu Arg Asp Val Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu 
    450                 455                 460                 


Asp Leu Glu Asp Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met 
465                 470                 475                 480 


Ala Phe Leu Ala Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg 
                485                 490                 495     


Asn Ile Leu Leu Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly 
            500                 505                 510         


Leu Ala Arg Asp Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn 
        515                 520                 525             


Ala Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys 
    530                 535                 540                 


Val Tyr Thr Phe Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp 
545                 550                 555                 560 


Glu Leu Phe Ser Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp 
                565                 570                 575     


Ser Lys Phe Tyr Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro 
            580                 585                 590         


Glu His Ala Pro Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp 
        595                 600                 605             


Ala Asp Pro Leu Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile 
    610                 615                 620                 


Glu Lys Gln Ile Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala 
625                 630                 635                 640 


Asn Cys Ser Pro Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg 
                645                 650                 655     


Ile Asn Ser Val Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val 
            660                 665                 670         


His Asp Asp Val 
        675     


<210>  10
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 
1               5                   10                  15      


Thr Glu Asn Leu Tyr Phe Gln Gly Ala Met Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Pro Trp Ile Pro Phe Thr Met Lys Lys Arg Lys Gln Ile Lys Asp Leu 
        35                  40                  45              


Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His Thr Pro His Leu 
    50                  55                  60                  


Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr Thr Glu Met Val 
65                  70                  75                  80  


Ser Asn Glu Ser Val Asp Tyr Arg Ala Thr Phe Pro Glu Asp Gln Phe 
                85                  90                  95      


Pro Asn Ser Ser Gln Asn Gly Ser Cys Arg Gln Val Gln Tyr Pro Leu 
            100                 105                 110         


Thr Asp Met Ser Pro Ile Leu Thr Ser Gly Asp Ser Asp Ile Ser Ser 
        115                 120                 125             


Pro Leu Leu Gln Asn Thr Val His Ile Asp Leu Ser Ala Leu Asn Pro 
    130                 135                 140                 


Glu Leu Val Gln Ala Val Gln His Val Val Ile Gly Pro Ser Ser Leu 
145                 150                 155                 160 


Ile Val His Phe Asn Glu Val Ile Gly Arg Gly His Phe Gly Cys Val 
                165                 170                 175     


Tyr His Gly Thr Leu Leu Asp Asn Asp Gly Lys Lys Ile His Cys Ala 
            180                 185                 190         


Val Lys Ser Leu Asn Arg Ile Thr Asp Ile Gly Glu Val Ser Gln Phe 
        195                 200                 205             


Leu Thr Glu Gly Ile Ile Met Lys Asp Phe Ser His Pro Asn Val Leu 
    210                 215                 220                 


Ser Leu Leu Gly Ile Cys Leu Arg Ser Glu Gly Ser Pro Leu Val Val 
225                 230                 235                 240 


Leu Pro Tyr Met Lys His Gly Asp Leu Arg Asn Phe Ile Arg Asn Glu 
                245                 250                 255     


Thr His Asn Pro Thr Val Lys Asp Leu Ile Gly Phe Gly Leu Gln Val 
            260                 265                 270         


Ala Lys Gly Met Lys Tyr Leu Ala Ser Lys Lys Phe Val His Arg Asp 
        275                 280                 285             


Leu Ala Ala Arg Asn Cys Met Leu Asp Glu Lys Phe Thr Val Lys Val 
    290                 295                 300                 


Ala Asp Phe Gly Leu Ala Arg Asp Met Tyr Asp Lys Glu Tyr Tyr Ser 
305                 310                 315                 320 


Val His Asn Lys Thr Gly Ala Lys Leu Pro Val Lys Trp Met Ala Leu 
                325                 330                 335     


Glu Ser Leu Gln Thr Gln Lys Phe Thr Thr Lys Ser Asp Val Trp Ser 
            340                 345                 350         


Phe Gly Val Leu Leu Trp Glu Leu Met Thr Arg Gly Ala Pro Pro Tyr 
        355                 360                 365             


Pro Asp Val Asn Thr Phe Asp Ile Thr Val Tyr Leu Leu Gln Gly Arg 
    370                 375                 380                 


Arg Leu Leu Gln Pro Glu Tyr Cys Pro Asp Pro Leu Tyr Glu Val Met 
385                 390                 395                 400 


Leu Lys Cys Trp His Pro Lys Ala Glu Met Arg Pro Ser Phe Ser Glu 
                405                 410                 415     


Leu Val Ser Arg Ile Ser Ala Ile Phe Ser Thr Phe Ile Gly Glu His 
            420                 425                 430         


Tyr Val His Val Asn Ala Thr Tyr Val Asn Val Lys Cys Val Ala Pro 
        435                 440                 445             


Tyr Pro Ser Leu Leu Ser Ser Glu Asp Asn Ala Asp Asp Glu Val Asp 
    450                 455                 460                 


Thr Arg Pro Ala Ser Phe Trp Glu Thr Ser 
465                 470                 


