                         SEQUENCE LISTING

<110>  Columbia University
       Lee, Francis Y
 
<120>  Methods and compositions for the treatment of sarcoma

<130>  88800730-0096

<150>  US 60/917,506
<151>  2007-05-11

<160>  11    

<170>  PatentIn version 3.4

<210>  1
<211>  720
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcgcacg ctgggagaac agggtacgat aaccgggaga tagtgatgaa gtacatccat     60

tataagctgt cgcagagggg ctacgagtgg gatgcgggag atgtgggcgc cgcgcccccg    120

ggggccgccc ccgcaccggg catcttctcc tcccagcccg ggcacacgcc ccatccagcc    180

gcatcccggg acccggtcgc caggacctcg ccgctgcaga ccccggctgc ccccggcgcc    240

gccgcggggc ctgcgctcag cccggtgcca cctgtggtcc acctgaccct ccgccaggcc    300

ggcgacgact tctcccgccg ctaccgccgc gacttcgccg agatgtccag ccagctgcac    360

ctgacgccct tcaccgcgcg gggacgcttt gccacggtgg tggaggagct cttcagggac    420

ggggtgaact gggggaggat tgtggccttc tttgagttcg gtggggtcat gtgtgtggag    480

agcgtcaacc gggagatgtc gcccctggtg gacaacatcg ccctgtggat gactgagtac    540

ctgaaccggc acctgcacac ctggatccag gataacggag gctgggatgc ctttgtggaa    600

ctgtacggcc ccagcatgcg gcctctgttt gatttctcct ggctgtctct gaagactctg    660

ctcagtttgg ccctggtggg agcttgcatc accctgggtg cctatctggg ccacaagtga    720


<210>  2
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  2
atgtctcaga gcaaccggga gctggtggtt gactttctct cctacaagct ttcccagaaa     60

ggatacagct ggagtcagtt tagtgatgtg gaagagaaca ggactgaggc cccagaaggg    120

actgaatcgg agatggagac ccccagtgcc atcaatggca acccatcctg gcacctggca    180

gacagccccg cggtgaatgg agccactggc cacagcagca gtttggatgc ccgggaggtg    240

atccccatgg cagcagtaaa gcaagcgctg agggaggcag gcgacgagtt tgaactgcgg    300

taccggcggg cattcagtga cctgacatcc cagctccaca tcaccccagg gacagcatat    360

cagagctttg aacaggtagt gaatgaactc ttccgggatg gggtaaactg gggtcgcatt    420

gtggcctttt tctccttcgg cggggcactg tgcgtggaaa gcgtagacaa ggagatgcag    480

gtattggtga gtcggatcgc agcttggatg gccacttacc tgaatgacca cctagagcct    540

tggatccagg agaacggcgg ctgggatact tttgtggaac tctatgggaa caatgcagca    600

gccgagagcc gaaagggcca ggaacgcttc aaccgctggt tcctgacggg catgactgtg    660

gccggcgtgg ttctgctggg ctcactcttc agtcggaaat ga                       702


<210>  3
<211>  1494
<212>  DNA
<213>  Homo sapiens

<400>  3
atgactttta acagttttga aggatctaaa acttgtgtac ctgcagacat caataaggaa     60

gaagaatttg tagaagagtt taatagatta aaaacttttg ctaattttcc aagtggtagt    120

cctgtttcag catcaacact ggcacgagca gggtttcttt atactggtga aggagatacc    180

gtgcggtgct ttagttgtca tgcagctgta gatagatggc aatatggaga ctcagcagtt    240

ggaagacaca ggaaagtatc cccaaattgc agatttatca acggctttta tcttgaaaat    300

agtgccacgc agtctacaaa ttctggtatc cagaatggtc agtacaaagt tgaaaactat    360

ctgggaagca gagatcattt tgccttagac aggccatctg agacacatgc agactatctt    420

ttgagaactg ggcaggttgt agatatatca gacaccatat acccgaggaa ccctgccatg    480

tatagtgaag aagctagatt aaagtccttt cagaactggc cagactatgc tcacctaacc    540

ccaagagagt tagcaagtgc tggactctac tacacaggta ttggtgacca agtgcagtgc    600

ttttgttgtg gtggaaaact gaaaaattgg gaaccttgtg atcgtgcctg gtcagaacac    660

aggcgacact ttcctaattg cttctttgtt ttgggccgga atcttaatat tcgaagtgaa    720

tctgatgctg tgagttctga taggaatttc ccaaattcaa caaatcttcc aagaaatcca    780

tccatggcag attatgaagc acggatcttt acttttggga catggatata ctcagttaac    840

aaggagcagc ttgcaagagc tggattttat gctttaggtg aaggtgataa agtaaagtgc    900

tttcactgtg gaggagggct aactgattgg aagcccagtg aagacccttg ggaacaacat    960

gctaaatggt atccagggtg caaatatctg ttagaacaga agggacaaga atatataaac   1020

aatattcatt taactcattc acttgaggag tgtctggtaa gaactactga gaaaacacca   1080

tcactaacta gaagaattga tgataccatc ttccaaaatc ctatggtaca agaagctata   1140

cgaatggggt tcagtttcaa ggacattaag aaaataatgg aggaaaaaat tcagatatct   1200

gggagcaact ataaatcact tgaggttctg gttgcagatc tagtgaatgc tcagaaagac   1260

agtatgcaag atgagtcaag tcagacttca ttacagaaag agattagtac tgaagagcag   1320

ctaaggcgcc tgcaagagga gaagctttgc aaaatctgta tggatagaaa tattgctatc   1380

gtttttgttc cttgtggaca tctagtcact tgtaaacaat gtgctgaagc agttgacaag   1440

tgtcccatgt gctacacagt cattactttc aagcaaaaaa tttttatgtc ttaa         1494


<210>  4
<211>  3843
<212>  DNA
<213>  Homo sapiens

<400>  4
atggatcttg aaggggaccg caatggagga gcaaagaaga agaacttttt taaactgaac     60

aataaaagtg aaaaagataa gaaggaaaag aaaccaactg tcagtgtatt ttcaatgttt    120

cgctattcaa attggcttga caagttgtat atggtggtgg gaactttggc tgccatcatc    180

catggggctg gacttcctct catgatgctg gtgtttggag aaatgacaga tatctttgca    240

aatgcaggaa atttagaaga tctgatgtca aacatcacta atagaagtga tatcaatgat    300

acagggttct tcatgaatct ggaggaagac atgaccaggt atgcctatta ttacagtgga    360

attggtgctg gggtgctggt tgctgcttac attcaggttt cattttggtg cctggcagct    420

ggaagacaaa tacacaaaat tagaaaacag ttttttcatg ctataatgcg acaggagata    480

ggctggtttg atgtgcacga tgttggggag cttaacaccc gacttacaga tgatgtctcc    540

aagattaatg aaggaattgg tgacaaaatt ggaatgttct ttcagtcaat ggcaacattt    600

ttcactgggt ttatagtagg atttacacgt ggttggaagc taacccttgt gattttggcc    660

atcagtcctg ttcttggact gtcagctgct gtctgggcaa agatactatc ttcatttact    720

gataaagaac tcttagcgta tgcaaaagct ggagcagtag ctgaagaggt cttggcagca    780

attagaactg tgattgcatt tggaggacaa aagaaagaac ttgaaaggta caacaaaaat    840

ttagaagaag ctaaaagaat tgggataaag aaagctatta cagccaatat ttctataggt    900

gctgctttcc tgctgatcta tgcatcttat gctctggcct tctggtatgg gaccaccttg    960

gtcctctcag gggaatattc tattggacaa gtactcactg tattcttttc tgtattaatt   1020

ggggctttta gtgttggaca ggcatctcca agcattgaag catttgcaaa tgcaagagga   1080

gcagcttatg aaatcttcaa gataattgat aataagccaa gtattgacag ctattcgaag   1140

agtgggcaca aaccagataa tattaaggga aatttggaat tcagaaatgt tcacttcagt   1200

tacccatctc gaaaagaagt taagatcttg aagggtctga acctgaaggt gcagagtggg   1260

cagacggtgg ccctggttgg aaacagtggc tgtgggaaga gcacaacagt ccagctgatg   1320

cagaggctct atgaccccac agaggggatg gtcagtgttg atggacagga tattaggacc   1380

ataaatgtaa ggtttctacg ggaaatcatt ggtgtggtga gtcaggaacc tgtattgttt   1440

gccaccacga tagctgaaaa cattcgctat ggccgtgaaa atgtcaccat ggatgagatt   1500

gagaaagctg tcaaggaagc caatgcctat gactttatca tgaaactgcc tcataaattt   1560

gacaccctgg ttggagagag aggggcccag ttgagtggtg ggcagaagca gaggatcgcc   1620

attgcacgtg ccctggttcg caaccccaag atcctcctgc tggatgaggc cacgtcagcc   1680

ttggacacag aaagcgaagc agtggttcag gtggctctgg ataaggccag aaaaggtcgg   1740

accaccattg tgatagctca tcgtttgtct acagttcgta atgctgacgt catcgctggt   1800

ttcgatgatg gagtcattgt ggagaaagga aatcatgatg aactcatgaa agagaaaggc   1860

atttacttca aacttgtcac aatgcagaca gcaggaaatg aagttgaatt agaaaatgca   1920

gctgatgaat ccaaaagtga aattgatgcc ttggaaatgt cttcaaatga ttcaagatcc   1980

agtctaataa gaaaaagatc aactcgtagg agtgtccgtg gatcacaagc ccaagacaga   2040

aagcttagta ccaaagaggc tctggatgaa agtatacctc cagtttcctt ttggaggatt   2100

atgaagctaa atttaactga atggccttat tttgttgttg gtgtattttg tgccattata   2160

aatggaggcc tgcaaccagc atttgcaata atattttcaa agattatagg ggtttttaca   2220

agaattgatg atcctgaaac aaaacgacag aatagtaact tgttttcact attgtttcta   2280

gcccttggaa ttatttcttt tattacattt ttccttcagg gtttcacatt tggcaaagct   2340

ggagagatcc tcaccaagcg gctccgatac atggttttcc gatccatgct cagacaggat   2400

gtgagttggt ttgatgaccc taaaaacacc actggagcat tgactaccag gctcgccaat   2460

gatgctgctc aagttaaagg ggctataggt tccaggcttg ctgtaattac ccagaatata   2520

gcaaatcttg ggacaggaat aattatatcc ttcatctatg gttggcaact aacactgtta   2580

ctcttagcaa ttgtacccat cattgcaata gcaggagttg ttgaaatgaa aatgttgtct   2640

ggacaagcac tgaaagataa gaaagaacta gaaggttctg ggaagatcgc tactgaagca   2700

atagaaaact tccgaaccgt tgtttctttg actcaggagc agaagtttga acatatgtat   2760

gctcagagtt tgcaggtacc atacagaaac tctttgagga aagcacacat ctttggaatt   2820

acattttcct tcacccaggc aatgatgtat ttttcctatg ctggatgttt ccggtttgga   2880

gcctacttgg tggcacataa actcatgagc tttgaggatg ttctgttagt attttcagct   2940

gttgtctttg gtgccatggc cgtggggcaa gtcagttcat ttgctcctga ctatgccaaa   3000

gccaaaatat cagcagccca catcatcatg atcattgaaa aaaccccttt gattgacagc   3060

tacagcacgg aaggcctaat gccgaacaca ttggaaggaa atgtcacatt tggtgaagtt   3120

gtattcaact atcccacccg accggacatc ccagtgcttc agggactgag cctggaggtg   3180

aagaagggcc agacgctggc tctggtgggc agcagtggct gtgggaagag cacagtggtc   3240

cagctcctgg agcggttcta cgaccccttg gcagggaaag tgctgcttga tggcaaagaa   3300

ataaagcgac tgaatgttca gtggctccga gcacacctgg gcatcgtgtc ccaggagccc   3360

atcctgtttg actgcagcat tgctgagaac attgcctatg gagacaacag ccgggtggtg   3420

tcacaggaag agattgtgag ggcagcaaag gaggccaaca tacatgcctt catcgagtca   3480

ctgcctaata aatatagcac taaagtagga gacaaaggaa ctcagctctc tggtggccag   3540

aaacaacgca ttgccatagc tcgtgccctt gttagacagc ctcatatttt gcttttggat   3600

gaagccacgt cagctctgga tacagaaagt gaaaaggttg tccaagaagc cctggacaaa   3660

gccagagaag gccgcacctg cattgtgatt gctcaccgcc tgtccaccat ccagaatgca   3720

gacttaatag tggtgtttca gaatggcaga gtcaaggagc atggcacgca tcagcagctg   3780

ctggcacaga aaggcatcta tttttcaatg gtcagtgtcc aggctggaac aaagcgccag   3840

tga                                                                 3843


<210>  5
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 


<210>  6
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         


His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 


Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 


Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp 
                165                 170                 175     


His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
            180                 185                 190         


Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
        195                 200                 205             


Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
    210                 215                 220                 


Leu Leu Gly Ser Leu Phe Ser Arg Lys 
225                 230             


<210>  7
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp 
1               5                   10                  15      


Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 
            20                  25                  30          


Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 
        35                  40                  45              


Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 
    50                  55                  60                  


Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val 
65                  70                  75                  80  


Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 
                85                  90                  95      


Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 
            100                 105                 110         


Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 
        115                 120                 125             


Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 
    130                 135                 140                 


Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met 
145                 150                 155                 160 


Tyr Ser Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 
                165                 170                 175     


Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 
            180                 185                 190         


Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 
        195                 200                 205             


Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 
    210                 215                 220                 


Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu 
225                 230                 235                 240 


Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 
                245                 250                 255     


Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 
            260                 265                 270         


Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 
        275                 280                 285             


Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 
    290                 295                 300                 


Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His 
305                 310                 315                 320 


Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 
                325                 330                 335     


Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 
            340                 345                 350         


Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 
        355                 360                 365             


Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 
    370                 375                 380                 


Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser 
385                 390                 395                 400 


Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 
                405                 410                 415     


Ala Gln Lys Asp Ser Met Gln Asp Glu Ser Ser Gln Thr Ser Leu Gln 
            420                 425                 430         


Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 
        435                 440                 445             


Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 
    450                 455                 460                 


Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys 
465                 470                 475                 480 


Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 
                485                 490                 495     


Ser 
    


<210>  8
<211>  1280
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Leu Glu Gly Asp Arg Asn Gly Gly Ala Lys Lys Lys Asn Phe 
1               5                   10                  15      


Phe Lys Leu Asn Asn Lys Ser Glu Lys Asp Lys Lys Glu Lys Lys Pro 
            20                  25                  30          


Thr Val Ser Val Phe Ser Met Phe Arg Tyr Ser Asn Trp Leu Asp Lys 
        35                  40                  45              


Leu Tyr Met Val Val Gly Thr Leu Ala Ala Ile Ile His Gly Ala Gly 
    50                  55                  60                  


Leu Pro Leu Met Met Leu Val Phe Gly Glu Met Thr Asp Ile Phe Ala 
65                  70                  75                  80  


Asn Ala Gly Asn Leu Glu Asp Leu Met Ser Asn Ile Thr Asn Arg Ser 
                85                  90                  95      


Asp Ile Asn Asp Thr Gly Phe Phe Met Asn Leu Glu Glu Asp Met Thr 
            100                 105                 110         


Arg Tyr Ala Tyr Tyr Tyr Ser Gly Ile Gly Ala Gly Val Leu Val Ala 
        115                 120                 125             


Ala Tyr Ile Gln Val Ser Phe Trp Cys Leu Ala Ala Gly Arg Gln Ile 
    130                 135                 140                 


His Lys Ile Arg Lys Gln Phe Phe His Ala Ile Met Arg Gln Glu Ile 
145                 150                 155                 160 


Gly Trp Phe Asp Val His Asp Val Gly Glu Leu Asn Thr Arg Leu Thr 
                165                 170                 175     


Asp Asp Val Ser Lys Ile Asn Glu Gly Ile Gly Asp Lys Ile Gly Met 
            180                 185                 190         


Phe Phe Gln Ser Met Ala Thr Phe Phe Thr Gly Phe Ile Val Gly Phe 
        195                 200                 205             


Thr Arg Gly Trp Lys Leu Thr Leu Val Ile Leu Ala Ile Ser Pro Val 
    210                 215                 220                 


Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ser Phe Thr 
225                 230                 235                 240 


Asp Lys Glu Leu Leu Ala Tyr Ala Lys Ala Gly Ala Val Ala Glu Glu 
                245                 250                 255     


Val Leu Ala Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln Lys Lys 
            260                 265                 270         


Glu Leu Glu Arg Tyr Asn Lys Asn Leu Glu Glu Ala Lys Arg Ile Gly 
        275                 280                 285             


Ile Lys Lys Ala Ile Thr Ala Asn Ile Ser Ile Gly Ala Ala Phe Leu 
    290                 295                 300                 


Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Thr Thr Leu 
305                 310                 315                 320 


Val Leu Ser Gly Glu Tyr Ser Ile Gly Gln Val Leu Thr Val Phe Phe 
                325                 330                 335     


Ser Val Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ser Pro Ser Ile 
            340                 345                 350         


Glu Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Glu Ile Phe Lys Ile 
        355                 360                 365             


Ile Asp Asn Lys Pro Ser Ile Asp Ser Tyr Ser Lys Ser Gly His Lys 
    370                 375                 380                 


Pro Asp Asn Ile Lys Gly Asn Leu Glu Phe Arg Asn Val His Phe Ser 
385                 390                 395                 400 


Tyr Pro Ser Arg Lys Glu Val Lys Ile Leu Lys Gly Leu Asn Leu Lys 
                405                 410                 415     


Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Asn Ser Gly Cys Gly 
            420                 425                 430         


Lys Ser Thr Thr Val Gln Leu Met Gln Arg Leu Tyr Asp Pro Thr Glu 
        435                 440                 445             


Gly Met Val Ser Val Asp Gly Gln Asp Ile Arg Thr Ile Asn Val Arg 
    450                 455                 460                 


Phe Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val Leu Phe 
465                 470                 475                 480 


Ala Thr Thr Ile Ala Glu Asn Ile Arg Tyr Gly Arg Glu Asn Val Thr 
                485                 490                 495     


Met Asp Glu Ile Glu Lys Ala Val Lys Glu Ala Asn Ala Tyr Asp Phe 
            500                 505                 510         


Ile Met Lys Leu Pro His Lys Phe Asp Thr Leu Val Gly Glu Arg Gly 
        515                 520                 525             


Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala 
    530                 535                 540                 


Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr Ser Ala 
545                 550                 555                 560 


Leu Asp Thr Glu Ser Glu Ala Val Val Gln Val Ala Leu Asp Lys Ala 
                565                 570                 575     


Arg Lys Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser Thr Val 
            580                 585                 590         


Arg Asn Ala Asp Val Ile Ala Gly Phe Asp Asp Gly Val Ile Val Glu 
        595                 600                 605             


Lys Gly Asn His Asp Glu Leu Met Lys Glu Lys Gly Ile Tyr Phe Lys 
    610                 615                 620                 


Leu Val Thr Met Gln Thr Ala Gly Asn Glu Val Glu Leu Glu Asn Ala 
625                 630                 635                 640 


Ala Asp Glu Ser Lys Ser Glu Ile Asp Ala Leu Glu Met Ser Ser Asn 
                645                 650                 655     


Asp Ser Arg Ser Ser Leu Ile Arg Lys Arg Ser Thr Arg Arg Ser Val 
            660                 665                 670         


Arg Gly Ser Gln Ala Gln Asp Arg Lys Leu Ser Thr Lys Glu Ala Leu 
        675                 680                 685             


Asp Glu Ser Ile Pro Pro Val Ser Phe Trp Arg Ile Met Lys Leu Asn 
    690                 695                 700                 


Leu Thr Glu Trp Pro Tyr Phe Val Val Gly Val Phe Cys Ala Ile Ile 
705                 710                 715                 720 


Asn Gly Gly Leu Gln Pro Ala Phe Ala Ile Ile Phe Ser Lys Ile Ile 
                725                 730                 735     


Gly Val Phe Thr Arg Ile Asp Asp Pro Glu Thr Lys Arg Gln Asn Ser 
            740                 745                 750         


Asn Leu Phe Ser Leu Leu Phe Leu Ala Leu Gly Ile Ile Ser Phe Ile 
        755                 760                 765             


Thr Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu 
    770                 775                 780                 


Thr Lys Arg Leu Arg Tyr Met Val Phe Arg Ser Met Leu Arg Gln Asp 
785                 790                 795                 800 


Val Ser Trp Phe Asp Asp Pro Lys Asn Thr Thr Gly Ala Leu Thr Thr 
                805                 810                 815     


Arg Leu Ala Asn Asp Ala Ala Gln Val Lys Gly Ala Ile Gly Ser Arg 
            820                 825                 830         


Leu Ala Val Ile Thr Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile 
        835                 840                 845             


Ile Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Ile 
    850                 855                 860                 


Val Pro Ile Ile Ala Ile Ala Gly Val Val Glu Met Lys Met Leu Ser 
865                 870                 875                 880 


Gly Gln Ala Leu Lys Asp Lys Lys Glu Leu Glu Gly Ser Gly Lys Ile 
                885                 890                 895     


Ala Thr Glu Ala Ile Glu Asn Phe Arg Thr Val Val Ser Leu Thr Gln 
            900                 905                 910         


Glu Gln Lys Phe Glu His Met Tyr Ala Gln Ser Leu Gln Val Pro Tyr 
        915                 920                 925             


Arg Asn Ser Leu Arg Lys Ala His Ile Phe Gly Ile Thr Phe Ser Phe 
    930                 935                 940                 


Thr Gln Ala Met Met Tyr Phe Ser Tyr Ala Gly Cys Phe Arg Phe Gly 
945                 950                 955                 960 


Ala Tyr Leu Val Ala His Lys Leu Met Ser Phe Glu Asp Val Leu Leu 
                965                 970                 975     


Val Phe Ser Ala Val Val Phe Gly Ala Met Ala Val Gly Gln Val Ser 
            980                 985                 990         


Ser Phe Ala Pro Asp Tyr Ala Lys  Ala Lys Ile Ser Ala  Ala His Ile 
        995                 1000                 1005             


Ile Met  Ile Ile Glu Lys Thr  Pro Leu Ile Asp Ser  Tyr Ser Thr 
    1010                 1015                 1020             


Glu Gly  Leu Met Pro Asn Thr  Leu Glu Gly Asn Val  Thr Phe Gly 
    1025                 1030                 1035             


Glu Val  Val Phe Asn Tyr Pro  Thr Arg Pro Asp Ile  Pro Val Leu 
    1040                 1045                 1050             


Gln Gly  Leu Ser Leu Glu Val  Lys Lys Gly Gln Thr  Leu Ala Leu 
    1055                 1060                 1065             


Val Gly  Ser Ser Gly Cys Gly  Lys Ser Thr Val Val  Gln Leu Leu 
    1070                 1075                 1080             


Glu Arg  Phe Tyr Asp Pro Leu  Ala Gly Lys Val Leu  Leu Asp Gly 
    1085                 1090                 1095             


Lys Glu  Ile Lys Arg Leu Asn  Val Gln Trp Leu Arg  Ala His Leu 
    1100                 1105                 1110             


Gly Ile  Val Ser Gln Glu Pro  Ile Leu Phe Asp Cys  Ser Ile Ala 
    1115                 1120                 1125             


Glu Asn  Ile Ala Tyr Gly Asp  Asn Ser Arg Val Val  Ser Gln Glu 
    1130                 1135                 1140             


Glu Ile  Val Arg Ala Ala Lys  Glu Ala Asn Ile His  Ala Phe Ile 
    1145                 1150                 1155             


Glu Ser  Leu Pro Asn Lys Tyr  Ser Thr Lys Val Gly  Asp Lys Gly 
    1160                 1165                 1170             


Thr Gln  Leu Ser Gly Gly Gln  Lys Gln Arg Ile Ala  Ile Ala Arg 
    1175                 1180                 1185             


Ala Leu  Val Arg Gln Pro His  Ile Leu Leu Leu Asp  Glu Ala Thr 
    1190                 1195                 1200             


Ser Ala  Leu Asp Thr Glu Ser  Glu Lys Val Val Gln  Glu Ala Leu 
    1205                 1210                 1215             


Asp Lys  Ala Arg Glu Gly Arg  Thr Cys Ile Val Ile  Ala His Arg 
    1220                 1225                 1230             


Leu Ser  Thr Ile Gln Asn Ala  Asp Leu Ile Val Val  Phe Gln Asn 
    1235                 1240                 1245             


Gly Arg  Val Lys Glu His Gly  Thr His Gln Gln Leu  Leu Ala Gln 
    1250                 1255                 1260             


Lys Gly  Ile Tyr Phe Ser Met  Val Ser Val Gln Ala  Gly Thr Lys 
    1265                 1270                 1275             


Arg Gln  
    1280 


<210>  9
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  9
ggauuguggc cuucuuuga                                                  19


<210>  10
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  10
ggagacuaga uugccuuug                                                  19


<210>  11
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  11
ggguuucuuu auacuggug                                                  19


