                         SEQUENCE LISTING

<110>  APPLICANT - Wisconsin Alumni Research Foundation
       AGENT - Greenlee, Winner and Sullivan, P.C.
       Thomas, Michael
       Felnagle, Elizabeth
       Rondon, Michelle
       Berti, Andrew
 
<120>  HETEROLOGOUS PRODUCTION OF CAPREOMYCIN AND GENERATION OF NEW 
       CAPREOMYCIN DERIVATIVES THROUGH METABOLIC ENGINEERING

<130>  GWS 86-07US and 86-07WO

<140>  US and PCT to be assigned
<141>  2008-05-09

<150>  60/917,628
<151>  2007-05-11

<160>  42    

<170>  PatentIn version 3.4

<210>  1
<211>  44141
<212>  DNA
<213>  Saccharothrix mutabilis

<400>  1
cttatcgatg ataagcggtc aaacatgaga attcgcggcc gcataatacg actcactata     60

gggatccgca gcgcgccggg ctcggtcggg tccgggtggt cgtccacggc cggcaggcta    120

ccggaccgga gcaccggtga tcatcggcct tgtgccgggg tgtcgcccca cgtctgcgcg    180

ggcgccacgt gcgagggacg gctctgaccg gcgaggagga cctccgccca caccgtcttg    240

tgctccgggt ggcggaccac gccccagtcg gtggacagcg cctgcacgat caccaggccg    300

cgaccaccgg aggcgtccgc ggtgcggatg cggggctggc cggagccggc gtcgtccacc    360

tcgacgcgca ggcgctgccc ggcccggacc aggcggcacc ggcggggcgg ctcgccgtgc    420

cgcaacgcgt tgctgaccag ttcgtccacc acgagcacgg cgtcgtccac cgcgaccccg    480

gcgcggtccg agagcagatc acgcacaagg tcacgcacct cgcgcacggc gaccccgtcc    540

agcgcgagca ccacctcgtc gccagactcg tctcccgcgt cccacgactg cgaggacatg    600

accacatcac ccccatcggg catcccgccg caccagcggc tcacgcgacg acataccccg    660

cgcggcgacc cgcgaatccg ccgggatgcg gactgcggcc cctctcacgc cctcgacgtg    720

cgtgcggctg accgggtgag ggcgggttcc cgatccggtg atcttgcttg cccgcaccca    780

ccgccgaccc gagactccgc cctatgacct ccacggagaa cgacctgctc ctcgacaaga    840

tcgggcgggg attcgaccac ctcgacgccg acggtgacgg gctgctcgac gagcgggacc    900

acgtcctcat gggcgagcgc gtcgcggcgg cgctcgggca cgggtccggg tcggcggaag    960

aggagcggat cgtggacatg tacgtccgcg tctggcacga cgtgcacctc ccccacctgc   1020

cggccgggac caccgccatc ggccgggacg agttcatcgc cgccacccgc gacctcgccg   1080

acgacccggc cgccgcggac gccacgctcg gcgccctcgc ccgggagttc ctccggatcg   1140

ccgacatcga cgccgacggc cgggtcacgc ccgccgagtt cctgaccttc cagcgcggcc   1200

acttccccga cctgagcgac gaggacgccg ccgccgcgtt cgagcacctc gacaccgacg   1260

gcgacggctc gctgtccccg gaggagttca tccgggccac cgtcgagtac tggaccagca   1320

ccgaccccga ctcgcccgcc aactggtgga tcggtcggcc gcggccgacc gcctgaggcg   1380

gatcagcagc cgggtttcgg gcagggcaac cgggacgccg cgccggtgag cagccgcagg   1440

gcgccctcgc ggctctcgtc ggcgggcatg ccctgcggtc tggcgttgcc gttcgccccg   1500

ccgtactcga ccgtcaggaa cacgttgtgg tccacggccc tgacccggct gtagctctgc   1560

accccgttgt acttgtgcat gacgtcgccg tcgtccaggc cggcgcccgt gatggccggg   1620

tccttcgcct gcgggtccga cgcgaggtgg tggcgggcgt tcccggtggc cgaccggccg   1680

tcgccggcgc ggtagcgcat gaccgtgacc gtgacgtagc ggtacagggg agtgccgggc   1740

gtgtcgggcg cccagtcgtc gtgcggcaac accggcacgt tgccggaatc gccgaactcg   1800

tggcggcact cgaccatgtc gacccggtcg tcagaaaacc ggaccggctc ccggctcggc   1860

ggtgcggcgg ggaggccgcg cgacagcgcg gtgaccgtcc ccgggtccac gaggtcgcac   1920

gcctcgatga gcgaaacgta ctcgggctct tccgccgcgc aggccgatgc caccgtcgcc   1980

aacaacaggg cgacgacccc cagtctcacc atgccgcgaa ccctagcgcg atcacgctcc   2040

agatgcggct gaccaccgat agtaggtgtt gatcgtgacc gggtcggccc catactcgcg   2100

agcggagcgg cggtcacccc caccctgcac cgaccgccgg ctcgtctgga ggtcttccat   2160

gaaactacgg gcgggacttc tcaccgcggc cctgttgctg ctgggaacca acgcgatggc   2220

cgccgcaccg gactcgacgc cgttctactg gcaggtcccg ggagccgatg agcgcacgct   2280

ccaggacgcc gggttcgacg tcgaacacgg cgtggacggc ggcgtgcagg tggtcgggga   2340

cgcgcgggtg gccggccggc tgaccgcgct gggctaccag ccgaagaagt tcgacaccgt   2400

ctacaagccg gtgccgcccg gccgcagcgg cgacatcggc gtccagacgt tctacggcgg   2460

ctaccacacg gtcgccgagc acgagaagca cctgaccgac gtggccgccg cgtaccccgc   2520

gctgacgcag gtgttcgaca tcggcgacag ttggcgcaag acccgcggcc tgggcgggca   2580

cgacatcaag gccatctgca tcaccaagaa gcaggccggc gactgcgcgt tgagccccac   2640

ctcccccaag ccccggttcg ccatgatcgc gcagttgcac gcgcgggaac tggccaccgg   2700

tgaactcgcg tggcgctgga tcgaccatgt cacccgcggc tacggcaccg acgccgaggt   2760

gacgtccatc ctggacacca ccgagctgtg ggtggtcccg atcgtcaacc ccgacggcgt   2820

ggacatcgtc gcctccggcg gcagccggcc gctgatgcag cgcaagaacg ccaacaacac   2880

cggcgcgtcc tgctcggtgc cgagctacgg cgtggacctc aaccgcaact ccacgttcaa   2940

gtggggcggc gcgggcacga accggtgcgg cgagacctac cagggcacgg cggccgggtc   3000

ggagccggag accagggcgc tggaggcgtg gttcaagcag ctgttccccg accagcgcgg   3060

ccccggtgac accgaccccg cgccggtgac caccaagggc gtgatgatca cgatccacag   3120

ctacggcaac ctgatcatgc cgccgtgggg ctggacgtgg aacgcgaacc cgaacgccgc   3180

gcaactggcc gcgctgggca agaagatggc ggcgttcaac gggtacacgg tggtggccga   3240

gggcgacacg acgggcacga ccgacgactt cacctacggc accctgggca tcgccagcta   3300

cacgttcgag atcgggtcca gcagcggcag ctgcggcggg ttcttcccgc agtactcgtg   3360

cgtggacagc ctgttctggc cgcggaacaa gggcgctttc ctgacggcgg cgaaggccgc   3420

caaggcccct tacgcgagct gacgccggcg gccggtggac gctaccccgc cgcgggtgcg   3480

tccgccggcc gcgcgacgga caggatgacc tcgcgcagcc ggtccacgta gaggcggatg   3540

ttcttgtacg ccacgtcgtt gtccgggtac cggcacgcga actggagccc ttcgtgcagc   3600

cgggtcaccc acacgcacac ctggtcgccg taggacacgc ggatcagccc gtacgccttc   3660

atgtcccgcc agcgctccga acccggcgtg gggcgggcgt ccatgaacga gacgatcgag   3720

tacaggtcgg gcgaggtggg gcggaagtcg tcgcccagca ggcgcagcac gcgcgcgacc   3780

ggcacccgcg acgccgggcg gctcgcgcgc agttcggcct gggccgcgcg cagcaggccg   3840

tcgaaaccgc ccgccgtggc cacgggcagt tccaccggca cgccgccgac gtaccagccg   3900

accgagtccg accaccgcga cttggcccgc gtgtggaacg gcacgaccgt gcggtagacg   3960

tcgtcgccgg tcatctcgcg catgatcagc gcggtggcgg cgaggacgcc gaccagggaa   4020

ccgccgtagg gccggcagtg ccgctcgaac gccgccgcgt cggcgtcgtc caccagcatc   4080

tcgtgcaacg acttctgcgt gggcagcggg ccgcccggcg ccaggcccag gtcgaacggg   4140

aagttcggca tccggccgtc gcagcgcgcc acgaaccgcc gccaccggtc caccaccggg   4200

tggtcggcgt ccacctcgtc ggcgtcggcg cgctcggtgg cgcagaagtc gacgtagctg   4260

gcgatcggcg cggcgtccac ggtgcggccg tcgagcgcgg cggcgtacag ctcgtgcagc   4320

tcggcgggga cgcggtacat ggagtaggcg tcgacgttgc tgtggtcgaa cgcgaggtag   4380

acgctcgtgc tgtcctcgcg ggccacggcc gcgtagatga agttgggcca ggtgagggtg   4440

tcggcggcga cgtcgaaccg gtcctggagg tgctgcacga gcacgtcggc gtcggtgaac   4500

tcgccgacgt cctctcggtg cagcgcgacg gcgtcggcgt cgagggtgaa ccggcgcatc   4560

tcgccgtcct cccaccggaa accgctgcgc agcgtctcgt gccgcaacgt ccacacccgc   4620

aacgcctcct ccagggcgtc gaggtccacc gcgcccggca ggtcgaacgc gacgcccagc   4680

cacgtcggga cgaacaggcc gtcctcgcgc aggctccggg ccgtgcgcac gtgcgactcc   4740

tgcaggtacg ccggcggtcg cgcgtcgtcc ggcgcgccgg tcgcggcggc cacggggcgc   4800

agcacccact ccacgacgcg ccctggccgg acctcacaac gctggacatc ggtgatgcgc   4860

atgaccttct ccgtctgcct gccggtgcgg cacaaggcgg cgcgcaggcg tacctgaaac   4920

cttcgggggg agggtggctc gtctcacgac cacacggcgg aatgtcgccg tacccgagcg   4980

aggaccttaa cgacggcccg atcaagaaac caccgccgaa gacccgagcc acgctatcga   5040

gtgaactcgt gatgtgactg ccgtcacaga tcaccggcaa ccggaatgac catgaccgat   5100

ctaacggttg gaccctaggt caaacgttag aacgcgcccg gaggccgaga tgaccagccg   5160

cttcgcccaa gtcatgttca ccccggacgt ccagctccac caggagcggc acggcagccg   5220

cgacgcctac gcccggatgg ccgacgccgc gccggtccgg gaccgcatcg gccccgacga   5280

ggcggcgttc atcgccgagc gcgacagctt ctacctggcc accgtcgggg agaccgggtg   5340

gccctacatc cagcaccgcg gcggcccgcc cgggttcctg cgcgtgctgg acgagcacac   5400

gctcggcttc gccgacttcc gcggcaaccg gcagtacatc acccgcggca acctcgacca   5460

cgacgaccgc gtggcgctgt tcctgatgga ctacgccaac cgcacgcgcc tcaagctcat   5520

cggccacgcc cgcgccgacg actcgcccga ggtcgtcgaa cggctcgcgc tgccggacta   5580

ccgggcgaag gtcgaacgcg cggtgctcat cgaggtcgag gctacgatct ggaactgccg   5640

ccagcacatc ccgcaactgt tcccgcgcga cgccgtggag caggccgtcg gcgcgctgcg   5700

cgaccggatc accgagctgg aacaggaaaa cgcccgcctg cgcgcgaggt gacgcgggcc   5760

ggccgggggc gtcgccgggg ccggccggat cggccggggt cgccgggtca ggcgggggcg   5820

tcaccgggtc aggcgggacg tcaccgggac agccggggcg tcatcgggac agccgccacc   5880

ggacctcgcc gtcgtgcacc tcgtcggtgg gcgcgagtcc ggcggcggtc gcgacggcgg   5940

ccgacgcgtg gtggtcgggg tggacgtggg cgacgaccgt gcgcacgccc tgccgcccga   6000

gccagtccac gagcccccgg gcggcttcac gggcgatccc ccgcccctgg aacggcgtcc   6060

ccaccaccca ggcgacctcc gcgaccgggc cctggtccgt ggggccgacc gtcgcctgga   6120

ccgtgcccgc caggcgggac tcctcgcgca gccggacgac ccagttcagc caggagaccg   6180

cgggatcggg cgagccggcg agcatgcgtt cgtagcgtga ccgcagggct cgcgggtcgt   6240

ccggggtgcc gccggtgaac gtgtgcaacg cgggatcggc caacacgacg gccatctcct   6300

ccgcgtggtc cacccgcaac ggcaccaggt cgaggcgggc ggtgccgatg gctggggcgt   6360

ggaggcggcc ggacatgtgg gccaacagta gtgctcaccc cacggtcacc acccgggccc   6420

acgccggcgg tgggtccggt cggtagtcgc ccggtttcgg tgggcggcgg aacaggccca   6480

cgaccgttcg gcacggcggt cgcacggtgg gccacggggt ctggccgtcg gtcagggcga   6540

cgatgacgtc cgggcgggtg cgcagggccc gggtgaagcc ggtgcgcagg tcggtcccgc   6600

cgccgcccat cagggggatg ccctcggctc ggcacagcgg gtgcgtcacg tgggcggcgg   6660

cgtcgcagga caggaccgac accaggtcgc gccggccgcc cacggcgcgg gcgatggcgg   6720

cgatctccag cagcgcgctg cccagttccg cgtcgctcac cgacccggag gtgtccacga   6780

ccacgcacac gcgcggcggc ctgcggcgca ggctgggcag cacgacaccg ggcagggcgg   6840

tggaccggcg cgccgggcgg ccgtaggtgt agtcgtcgcc cgcgcccgcg gccgacgcgg   6900

ccgagcggac cgccgcgccc agcaggtcgc gccacggctg gggcgggtgg aacgcccgct   6960

ccgcccaccg ccgccagccc agcggcacgt cgcccggccg gccggtgatg gcctcggcga   7020

cccggaaccg caccgcgtcc cgctcctgct cgctgagccc gtgcgcgccg tccggcccca   7080

ggtcccactc gcgctccagg ccgtccgcgc cgctgccgca gtccagccac gtgaacgcgt   7140

cggtgtacgg gccgagccgg aactggcgca ggtagtcctc catcaactgc ccctcgcgca   7200

actgcagcag ttccggctcc accgcgccct cgggccgtgc caacccgtcg ccgaacacgt   7260

cgtcgttgat ctcgcagtca gcggcgatgt tcatccgcaa ccgctccccc ggcccggtca   7320

gcccgtgctc cgcggcgaac cggtcgccgc gcccgtggtg gtcgcgcagc aggtgcgaca   7380

cctcgtgcac ccacaccccg gccaactcct cctccggcgt gcggtccacg aaggccgggg   7440

agacgtaaca acgccagtgc cggtccacgg ccatcgtcgg cacccgccgc gactccacca   7500

cgtgcagcgc gaacaacgcc gtcgccaggt acggccggca gcgcaccgcg tgcagccggg   7560

cggcgaacag cttgcgctcg tccaggctca ccggcccgcc ccgacgcgcg ccgccgtccg   7620

gtcggccagc cgcgacaccg acaccgcgcc ggagagccgc tcgatcgccg ccggcacctc   7680

ccagtcgtcg cggcgcaacg cggcgagcgt cgccgccggc acgacgacca ggtccggcgc   7740

gccggtgtcc aacgcccgca ccaacaacgc ccacgccgcg tcccaccgcg ccgcctccgg   7800

acgtcgccgc accgcctcca ccacaccgtc gagcaccgct tggcgcaggt cgccgcgctc   7860

gggcagcacg gccgccgccg ggttcgcgag cagcgactcg gggtcgggca ggtccatccg   7920

gtccaggctc gccagcagct ccaggcccgg cccgtcgccc acggtccccc gcacgagcat   7980

cgacagcacg tcccgggaca cgtccgccgc ggtggcgaag gcgatcagcc gcaacgccat   8040

ctcccagctg cgcggcgacg gccacggacc accgcgccgg gtctcgtcct tgggcagttg   8100

gtgcaccagg ttggggcggg cggccagcag ttcgcacacc gcccgacgcg cgtaggccac   8160

ggcgtccggc aagcggcccg ggtccaggcg cggcagctcg gcccgcggcc acgtcccgcc   8220

cagcccgcgg accaccacgt cgtggtcgtg ggcccactgg aggtggacga accggttggc   8280

cagcggcggg ctgagctccc agccgtcggc ggcggacgag cgcgggttgg cggcggccac   8340

gatccgcacg cccggcggga gggtcagcgc gccgatccgg cgttcgagga cgacccgcag   8400

gagcgcggcc tggaccgccg gcggcgcggt ggacagctcg tccaggaaca gcagtccgcg   8460

gccggcgcgg accaggcgca ccgcccagtc cggcggggcc atcggaacgc cctgcaccgc   8520

cgggtcgtcg ccgacgacgg gcaggccggc gaagtcggac ggttcgtgca cgctcgcgat   8580

gaccgtggtc agcggcaggt cgagggcgtc ggcgagctgg gtgagggcgg cggtcttgcc   8640

gatccccggc tcgccccaca gcagcaccgg caggtcggcg gacacggcca gggtcagggc   8700

ttcgagctgg gcgtcggaac gggtttcggt ggtcgtgcgg ccgagcaggg cgagcaggtc   8760

ggcggcgacg tcgagcggtc gcgcggacag ggaagtgggc atattcgggc accctcgggt   8820

tgcgtaggga cgtgcgtcgg ccgagcgagc acgcgggggg attcagcgag agaacgcgtg   8880

gcgcgggcgg acccgtcgcc gaccgtcctt tgtggaggga gccgggccgc cggcgagtcc   8940

ggcccggtac aggccgtgcg ccagccggcg gcggaccgcc gcgtccagct cgtcgcgcag   9000

cgcgccggcg cgcaggagcg cctccgggcc gagcagggct tcgacggccg cgacggcgcc   9060

ggcggtgtcg ccgtggtcga gccgggcgcg aacgtccaca agggactccg gttgtcggtg   9120

cacgtcgtcg atcgcccgca ggcacggcaa cggcggaccg ccccactcgg ccagcagctc   9180

ctcgcggcgg acctcgtcgg ggtcgtggtc cagcggcacc aggaccccgt ccacgacgcc   9240

gatccggtgc gtcgcgccgc ggcactcgac caggcgcgga cccgttgcgg ggtcgggact   9300

tccggttgtt cgccggtggc cggggaccag ggccgacgcg accagcgggt gcagccggtc   9360

ggcgtcgacc aggccggcgc ggagcaggtc gaggtcgggt ggtgtgcggg tggcggcgtc   9420

gggcaggacg ggccgggtgg ggtctcgtcg gggagcggcc gtgagcacgg gtgtcggctc   9480

gtccggggcc agcgccaacc accgaccggc gttgagccgc acggtgatca cgcggtcggc   9540

gcaccggtcc gcgcgcagga ggagcaaggc ctccggcacc caacgaccga cagcgaaacc   9600

ctccccctcg acggcccacg gcgcggcggg tccctcggct ggcggcggcc cgacggccca   9660

cgaacgcggc gggcccctcg gctgccggcg acccgacggc ccgcgagccg gctgcgcgca   9720

gcgcggtggt caaacccggg cgggggatcg ccgcccgcgg accgttcccg cagctcgccg   9780

gcccggcgcg cgtcccacag gtggcggtgc aggtccaggc ggaaccgccg gtccggccgg   9840

gggtgcgggt gcgtgcccgc gccggcccgg ggttcggccg ggtcccacca cgccaggctg   9900

atccgctgcc cggctgccgc ccacgccggt ggcgtgcgcg ccacgaggtg cgggcccgcc   9960

gcgtaccggg ccagggacac ggtgagcccc gggcgcagca agccgtccgg accgatcctc  10020

gggaagtgcc agcgcagcag gtcgggggcc aggtgccgca ggtcggcgcg gacctgtgcc  10080

gcgagctgcc gaccgtgggt ccggcccacg gcccgcaggt ccaggtccac gtcgaagcgc  10140

gcggcggcac aggccccggc ccagtcgccc accgagcggc gggcggtcgc tgtctcgacc  10200

atcgacggcg gcacggcgaa ctcgcgcacg cgcgtccaga agtgaaggcg aaggttctca  10260

tccgcggtgg tgtggtgcat cagcactcac cttgcgcgaa tgaaaccccc gatctaccag  10320

agaaggtgat catcgcggcc gagcgtacca gcaaacggcg ctcaggtgtg cgagacgacg  10380

agccggaaac cggcgtccca ctggtcgagg tcgagcaggt cgcggtggtc gtcgtgccac  10440

cggccgctgt cgaggtccgc gcgcaggcgg cggacgccgc ggtccacggc ggcggggtcg  10500

gtctgggcca gggcggagca cgcgcggcgg acgcgcgggt cgaggtaggc gtccgggcgt  10560

cgccagtacg cggggaagac gccgtcgacg aagtcccacg gcagcggcag cggcgtgacg  10620

ctgtccgcgc ccagttcgcc cgcgatgtcg gccgccgacg ggcgggtgcg ttccaggtcg  10680

gcgatctcgg gcacgtactc gcggacgaac cagaactcgg tgtgcaggct cgtgtcgtag  10740

gccagcacga cccggcgcgg cgcgatccgg cgcagttcgg cgagcccggc ccgccagtcg  10800

gtccagtggt ggacggtgag cacggccagc gcggcgtcca cggcgtggtc gcgcagcggc  10860

agggcctcgg cgaccgcgcg cacggccggt ccgacctccg gcgggcgttg gcggatcatc  10920

tccgtggacg gttcgagggc gaccaccgtc cggtcgtccg gctcgtagga gccggtgccc  10980

gcgcccacgt tggcgatcgt ccgcgcgccg ccgagcgcgt cgaggatcgc ggtcatccac  11040

cgcgggtcgg tgcggcggcc cagcgcgtaa cccgtgccga tgtcgtcgta gagatccgtg  11100

ccggccactg tccccccagt gctcaagcgg aaagtttcga cgtgggcggc gacgggccgg  11160

tccgggaggg cccggatcgg ccgtcgtcac ccgcgggttc ggccccggcg gtcacgccga  11220

cgcgccccgg ggcttcacca cctcgggggc ctcgcgcgcg gtcaccaggc ccaggcgcca  11280

ggccagcaga gcggcctgga cgcggtctcg cagctccagc ttggccagca cccgggacac  11340

gtggctcttc accgtggtct cgctgacctc gaactcgcgg gcgatctcgc ggttggaccg  11400

cccctggccg atggcgcgca gcacctggcc ctcccgttcg gtcaacgaca gcagggccgg  11460

cgccgacggg tcgggcagcg ggatgatctg gaagctctcg aacacccgct tggtgacgtg  11520

cgcgggcagg tacgcgccgc cctcggccac cgcccggatc gcgcgcggga actcctcccc  11580

cggcgacccc agcggcaggt agccgctcac acccgccgcg atcgcggaca ccagcagctc  11640

gtccgagtcg tcctgggtgg ccaccacgac ccgctgcccc gccagcagcc gcgccacccg  11700

gaaatcgtcc acccgcaaca acgacgcccc gaccagcacc acgtccggct ggtcgcggcc  11760

gatccggtcc agcagttccg gcacgccgtg caccgcgccg accacggtga tcgcgtcgtc  11820

ccgcgcgagc acggcccgca ggccgtccag gatcacctcg tggtcgtcgg cgagcagcac  11880

ggcgatcccc cgccgcgccc gccccgcccc ggccggcgtc agcacgctta tcgccccggt  11940

ctcccgacgg taccggggcc cgactgaata ctcgtccgac acttctccgg tcacgttctt  12000

ccgaccccct cggccacggg ttttccccac ggcgtttcga aacagtcgcg gcgggcgcga  12060

aaacaccacc ggaaccgcga gccgcccggg accaccgacc cgcggcaccc cggccgtctg  12120

cttcaccatc cccaggcgcc gccggcaatc cggatcgacg ccaccccagt tgcaaacaat  12180

atgcattaac acccaaccta ccggaccacc ggacgggcgg caacgtccgc acggtgtgtg  12240

cacgcactca cactaacgcg ccaattaggc ggggagacat gccgctttag aagtaatccc  12300

ggcaacgccg ggcgtcgatc cgccacgcgc cgcgccctcc acgccgagca cgtcgaactc  12360

ctcccggcag gcccccagcc gacgggtcca cgtgctggtc aactcgctcg cgccgacatc  12420

ggccaggtac ccggcccggg taacgcgcag gcccgcctcg gcgtagacgt gggccagttc  12480

ccggcgcacc cattcgggtg tcggttcggc gatcccggtg acggcggggg ccgccggccg  12540

ccaggcgtgg aggttcacgg tgatgtggaa ccgggcgccg gcgcggcacg cgcccgccag  12600

gccggcgagc acggcggggt cgcgcccgag gacaccgcgc agcaggctgc cccacggcat  12660

caacacgtgc atttcgtcca catcgcccag acagggcggc atctcctcgg cggcggcgtg  12720

gaccagcacc aggttgggca gcccgccgcg cgcgggtttg gcggcggcgc gcgcggacac  12780

gccccgcatc cggtcggggt tggcgtccac gccgaccacc agccggtcgg ggtcggcgcg  12840

ggcgagccgg taggcgtgct tgccgtcgcc ggtgcccacg tcgagcagga ccgaccggtg  12900

acgggcgcgc aactcggcga actcggcgtc ggcgagcggc acgcaccgct tgccgacgac  12960

cttgaccaga ccttcggaag gcatgacggg gcccttcgcg tgagtgggtg aggacctgcg  13020

ggaaacggcc ggcgacggac cgcagaatta cggggaaaca ccctccggga catcgccgga  13080

ggacccttgt caatcgttgc cggaaatacc ggccgctgcc cacccctccg gagcagcgcg  13140

gagcccggtc ctgggaaaat gtggccgtaa atcacgccaa tgggggaagt gaaccccgtc  13200

aaaatcactc tgcgtgatta gttttctcct accagcggac gagacgtcac cctacttcgg  13260

aaggaacggt gctcgttcga aatatccgca ccgggcattc gccggaatga gccggcgggc  13320

cacccaaaga agtctgtcga aaacggcgga gtcgctcata ggctgagcgg cgtccccaat  13380

tcgcgacgac cggagggcca tttgcccggg ccgggtcgga tcgacatcag ccggagacgc  13440

caccatgacc gttgacccca cgatcgagct gcgcctgacg ctgaacggcg acccggacgt  13500

gcccgcgctg acccgggcgt gggcggcgct gcgcgcccgg caccgcgccc tggccggtcc  13560

gctgggtgcg caccgggacg tcgccgcgtt cgaggacgcg gtgcgcgcgg gccccggctg  13620

ccacctgctg cgcgcccccg gccggcacga gttcgcgctg accgccgggt gcgacgcggc  13680

gtcggtgccc gcggtcctgg ccgagctgtc cgcgctctac gcccgcgagc tgggccaccc  13740

ctccgagggg ctgcccgcgc cggccccggc cgtcccgcac gaccgcccgc cgcacgacgt  13800

tcccccgccc ggaccggagc tgccgggcct ggagctgttc gggcgcggcg aaccgggccc  13860

gcgcgtggtg acccgcgtgg acctcggcca cccgacccgc cggcacgtct ccgcgctggc  13920

ccgccggcac ggcgtgaccc gcgaggtcgt cgtggtcacc gcgtgggcgc tgctgctggg  13980

cgagctggcc gagcgggacg agttcgtgct gggcctggtc accgatcccc gcgacccggc  14040

cgcgcaccga cccgccgtgg gcgcgctgcg cgaggcccgc ccgctgcggg tggacctgac  14100

cggccggccg tcgttcgccg acgcggtgcg ccgcaccacc gccgccgtgg cgaccgcccg  14160

gtcccgcccc ggtgacgcgc ccgccgacgt ggcggtgcag tacggcgagc agccggcggc  14220

ggcgctgcgg ctggccggcc tcgaccccgc cgaggtcccc gccgccttct ggctggccga  14280

cgacctcccc ggcccgcacc gggtcgtgct gcgcctgctg gacacccccg acgggctgct  14340

cgccggcgtc gcgcaccacc ccgacgccct ggacgggccc ggcgcgcggc gctgggtgtc  14400

ccggctggcc gcgctgctgg ccggcgcgca cgacgagtcg cccgagcccg tggtgatgtc  14460

cgaggacgag caccgccggg tcgtgctcgc gcccaacgcg accgccgtgg acctcggcgc  14520

gcccgcgacg gtccacgacc tggtcgccga gcaggcccgc cgcaccccgg accggaccgc  14580

gctggtcttc gccggcgccg aggtcggcta cgccgagctg gacgcccgcg ccaaccgcct  14640

cgcccacgag ctgcgcgagc gcggcgtgcg gcgggagacg ccggtcgcgg tgtgcctgga  14700

acgcgagacg ggcctggtgg tcgcgctgct ggcggtgctc aaggcgggcg gcgcgttcgt  14760

gccgctggac ccgcagtacc cgcggcagcg cctggcccac atgctcgccg actcgggcgc  14820

ggccgtggtg ctcacccagg gtcggctgcg cgaccggttc gccgccgacg gcccgcccgt  14880

gctggtgacc gacgacgacg cgacccggtt cgcccaccac ccgagcagcg cgccgccggc  14940

gtcgtccggc ccggacgacc tcgcctacgt cgtctacacc tcgggatcga ccgggcggcc  15000

caagggcgtg atggtcgagc accggggcat cgcgtcctac ctgcgcggaa tgcagcacga  15060

cttcccgctc acgcccgagg accgcgtgct ccaggcgacc tcgctgtcct tcgacgtgtc  15120

ggtgtacgag atcttctggc cgttgcaggt gggcgcggcg gtggtgctgc ccgcgcccgg  15180

cgggcacacc gacccgtacc acctgtcgga gctgatccag cggcacggcg tgacgtgcct  15240

gcacttcgtg ccgtcgctga tgcggttgtt cgtggaggag gccgacccgg gggcgggcgc  15300

cgggctgcgg cgggtgttcg tgtccggtga ggcgctggac ccgtcgctgg tggcgctggt  15360

gcacgagcgg acctcggcgg agctggtgaa cctgtacggg gcgacggagg tgtcggtcga  15420

ctcgacctac tggaccgccg accgcgccaa gcccgaccgc ccggtgctgg tggggcggcc  15480

gatggccaac gccacggcgt acgtgctgga ccagcggttg cgacccaagc ccgcgggcgt  15540

ggtcggcgag gtcttcctgg gcggcgcgag cgtcacccgc ggctaccacg cgcggccggc  15600

gctgacggcg gagcggttcg tgcccgaccc gttcgggcca cccgggtcgc ggctgtaccg  15660

gaccggcgac ctgggccggg tgaccccgga cggcgagctg gagttcctgg ggcggcgcga  15720

ccaccagttc aagctgcgcg ggtggcgggt ggaggccggc gagatcgagg cggcgatcac  15780

cgcgcacccc ggcgtgaacg gcgcggtcgt ggtgaccgag ggggcgcacg agcacgcgac  15840

cctgctggcc tacgtgggcg cggacgcggg gctggaccag gcggcgctgc gggagttcct  15900

ggcgcggcgc ctgccccgac cgctggtgcc ggcgcggttc atccgcctgg accgcctgcc  15960

gatctccccc aacggcaagg tggaccgcgc cgccctgccc aagcccgacc aggcgcccgc  16020

cgagcccgcg ccgaccaccg cggcaccgcc gacgcacgcc gcggacggtc ggcccgcgtt  16080

ggagcacgcc gcggacggtc ggccggcgct ggagcgcggc tcggacggtc ggccggtgtt  16140

ggaggtggtg ctggcggtcg cggccgaggt gctgggcgcg ccgatcgggc cggaggacag  16200

cttcttcggc tccggcggca actccatcca ggccacccgg ctggccgccc gcctgcgcgc  16260

cgccctgcgc accgacgtcc cggtgcggct ggcgttcgag gcgcccacgc cggccgcgat  16320

ggcggcgctg ctgtccccgc cgtcccccga gcccgtcgcc gaggtctccc gggccgagca  16380

acggatctgg ctgctcagcc ggctcggcgg ccaccccgcc gagtacgcga tccccgtggc  16440

gctgcgcctg gccggcccgc tggacgtcgc caagctcaag aacgccgtgg acgcggtcgt  16500

gcgccgccac gaaggcctgc ggcacgtctt ccccgaggtc gacggctccc cgacgcgggc  16560

cgtgctcgac ccgggctcga tcaccgtggc cgaggaggcg aaccggtcgg tgcgcgaggt  16620

gctcgccgag ggtgtcgccg cgctggaccc cgcgaccggc ccactggccc gcttcacgct  16680

ggtcaaccag ggcccgcagg accacgtgct ggccatcgtg ctgcaccacc tcatcgccga  16740

cggctggtcg gtggacgtgc tgctgcgcga catcgccgcc cactacaccg gcgcgccgac  16800

cgccaccccc ggccgctacg ccgactacct cgccctggaa cgggccgagg agcaggacgg  16860

cgccctgggc cgcgccctgg agcacttcgt caccgcgctg gacggcgtgc ccgacgaggt  16920

cagcttcccg cccgaccacc cccgccccgc gcaacgcacc gggcgcggcg acgtcgtgcg  16980

ccaccggatc gacgccgcgc cggtcaccgc gctggccgaa cgcctgcgca ccacgccgtt  17040

cgcggtgctg ctggcggcgg tgggcgtgct gctgcaccgc gtcggcggcc accgggacgt  17100

ggtggtcggc acggccgtcg cccgccggcc cgacgccggg ctggaccacc tggtcggcct  17160

gtgcctgaac acgctcgccc tgcgctggcc cgtgcagccg cacgacacgc tgggcgaggt  17220

ggtccgcgcc gtgaccgacc ggctcgccga cggcctccag cacgacgccg cgtcgttcga  17280

ccgggtggtg gacaagctcg cccccgcccg cgacagcggt cgcaccccgg tgttccaggt  17340

gatggccctg tacgaggagc cgtacgagac cgcgctggcg ctgccggacg tgacgaccac  17400

cgacgtgacc gtccactgtg gatccgcgca ggcggacgcg gcgttcgggt tcgtgccgcg  17460

cgagggcggg atcgacctca ccctccagtt ctccaccgac gtgttcaccc gcgccacggc  17520

gagccggtgg gcgcgccgcc tggcgaccct gctggccggc gcgcgggcgg acaccagggt  17580

cgcggacctg ccgctgctgc cggaggacga aagccaggac ctggaacgct ggagcggcac  17640

cacaggggaa gcgccgacca ccacgctgca cgccctcgcc cacgagatcg cccaacgcca  17700

ccccgaccgc ccggcgatcc acttcggaca gaacagcctg acctacggcg agttcgacgc  17760

gcgatccgct cagctcgccc acgagttgcg cgcccgcggc gtccgagccg aaaccccggt  17820

cgtggtgtgc ctggaacgct ctcccgaggc gctgatcgcc gtctacggcg tgctgaaggc  17880

cggcggcgcg tacgtgccgg tggagaccag caaccccgac ctgcggatcg ccgagctgat  17940

cgccgactcc ggagcggcgc tggtcctcac ccagcggcga ctcgccgacc gcctggccgc  18000

gctgggcgcg gaggtcgtgg tggtggacga gccgctgccc cggcacccca ccaccgaccc  18060

ggagccgctc accggtcccg accacctggc gtacgtgatc tacacgtccg gctccaccgg  18120

ccgccccaag ggcgtgatgg tgcagcacgg gtcggtgctg aacttcctcg acgcgctgga  18180

ccgccgcttc gacctcaccc ccgacgaccg gctgctgcac aagtccccgc tggcgttcga  18240

cgtgtcggtg cgcgaggtct tctgggcgct gacccggggc gcgtcggtcg tcgtcgccga  18300

acccggccgg cacgccgacc ccggccacct ggtggacctg gtcgagcggg agcgggtcac  18360

cgtcgcgcac ttcgtgccca gctcgctggc ggtgttcctg gagggcctgc ccggaccggg  18420

ccggtgcccg accctgcggc acgtcctcac cagcggcgag acgctgcccg tgaccacggc  18480

ccgagccgcg cgcgacctgc tgggagcccg gctgcgcaac atgtacggcc ccaccgagac  18540

cacagtcgag atgaccgacc acgacgtcgt ggacgacacc gtggaccggc tgccgatcgg  18600

ccacccgttc gagggcgcgg tcgtgcgcgt gctggacgcg gacctgcggc cggtgccgcc  18660

gggcagcacc ggtgagctgt gcgtcggcgg cctgccggtg gcgcgcggct acctgggccg  18720

cccggcgctg accgccgagc ggttcgtgcc cgacccgctg gggccggcgg gcgcgcggct  18780

gtaccgcacc ggcgacctgg cccggctgct gcccgacggg caactggact tcctgggccg  18840

caacgacttc caggtcaagg tgcgcgggca ccggatcgag cccggcgagg tcgaggcggt  18900

gctcggcgcg ctgcccggcg tgcacggggc gctggtcacc gcgcacgacg accggctcat  18960

cggctacgcc gtcaccgacc gggacggcga ggagctgcgg acggcgctgg ccgagcggct  19020

gcccgagcac ctggtgccct cggtggtgct gaccctggac cggttcccgt tgaccggcaa  19080

cggcaagctc gaccgcgcgg cgctgcccac ccccaccggc cggcacaccg gcgacagccg  19140

cccgctgacc gcgaccgagg cggcgctggc cgcgatctgg cgcgacctgc tggacgtgcc  19200

ggaggtgcgg gcggacgacc acttcttcgc gctgggcggc cactcgctgc tcgcggcccg  19260

ggtcgccgcc cgcgccggcg ccgcgctggg cgtggcgctg cccttgccga ccgtgctgcg  19320

cttcccccgc ctcgcggacc tggcgaccgc ggtggacggc acgcgcgccg accgcgaacc  19380

cgtccggccc cggcccgacc ggcggcgccg cgcgccgctg tcgtccgcgc agcgccggct  19440

gtggatcgag gagaacctgc gacccggcac cgccacctac accgtggccg aggcgttccg  19500

cctgcgcggc gagctggacg aggaggcgtt cgcggcggcc gtggacgacg tgctgcgccg  19560

ccacgacgcg ctgcgcgccc acgtcgagtc cgtcgaggac ggtgaaccgg agctggtggt  19620

cgcgcccgag ccgcgcaccg cgctgcgcgt cggcgacctg ccggccgacc gggtgcggga  19680

cgcgctggcc gccgagtcgg cccgggtgtt cgacccggcc ggcccgctgg tggccacgag  19740

cctgcaccgg ctcgcgcccg acgagtggct gttccagttc accgcgcacc acctggtggt  19800

ggacggctgg tcgctggacg tgctgtggcg cgacctggcc gcctgctacc acgaccgccg  19860

cgcaggccgc gcgccgcgac cgcgcgacgg gctgaccttc accgactaca cgtggtggga  19920

gcgggacgtg cggtcccgcg acctggaacc gcacctggcg ttctggcgcg gggaactggc  19980

cgggttgcgc ccgcagcccc cggccgacgc gcacggcccc ggcgcggtgc tggacttcgc  20040

gctcggcgcg gcgctgtccg acgagctgcg cgccaccgcc gccggcctgg gcgtctcgcc  20100

gttcgtgctc gggctgaccg cgttcgcgct ggcgctgggc gaggactcgc cgggcgcgat  20160

cggcgtggag gtggccaacc gggcctccgc cgagaccgcc gacctggtgg ggctgttcgt  20220

caaccacgtg ccggtgcggg tggcgccgcg cggcaccggc cgggcggcgg tggcggcggt  20280

ggacgaggcc cgccggcgcg tcctgccgca cgagcacgtg ccgttcgacc tggtggtgga  20340

cctgctgggg cccgggaggg cgccgacgag cgtggcgttc tcgcacctgg acgtgcgcgg  20400

gcactcgccg cggctggacg gcgtcaccgc cacccggctc accccgccgc acaacggcac  20460

cgccaagttc gacctcctgc tggaggtgct ggacaccgag cacggcctga ccggggcgtt  20520

cgagtaccgg cccgagcggt tcaccgccgc ccgcgtcgcg caggtccgca accactggga  20580

ggccgcgctg ctgacgctgc tggccgaccc ggacctgccg gtggacgccc gccgacccga  20640

tttcgcgtga tgtcgagggg gaacgacgtg ctgtcaacgg tcgatccggc ggcggagctg  20700

agcaccaccg ccgccgaggt cctggaacac gtggacgccg cggtggcggc gtacccggag  20760

gtgccgatcg cccgcgtgcg ggtcgaggtc gcgggcatcc cgcgcaccct gctgctgaag  20820

ctggagggcc gctcgccgtg gcggtccatc aagggccgca ccgcgctggg cctggtccgc  20880

tcgatcgcgc cgcgcatggc gtcgcgggac gtcacggtcg tggagtccac ctcgggcaac  20940

ctgggcgtgg cgctgtcggc gatctgccgc gacctgggcc tgccgttcgt ggccgtggtg  21000

gacctcaagc agtcgccggt gatccaggcg gcgatcgagg ccaacggcgc gcggctggag  21060

gtcgtgcgga cgccggcggc ggccaccacg cacctgctgg accggctgga ccgggtgcgc  21120

aagctggtcg ccgagatccc cggcgcggtg tggcccaacc agtacgagaa cgacgccaac  21180

cggcacgtgc acgagacgtg gaccgcgccg gagatcgacc gccaggtcgg cggcgaggcg  21240

caggcggtgt tcgtcgcggt gtccaccggg ggcacgctgg cgggcctggc cgcccacttc  21300

cgccgcgccc gcccggcgac gcgcctggtg gccgtggacg tcgagggctc gacggtgttc  21360

ggcggcgtgc ccggcgggcg cgtgctgacc ggcatcggcg cgagccgccg ctccaccttc  21420

ctgacccgcg ccgagtgcga cgacctggtg tacgtgcggg aggcggcggc gatcgccgcg  21480

tgccacgtgc tgcgcgccga caccgggatc gcggtcggcg ggtccagcgg cgcggtcgtc  21540

gcaggcgcgc tggaccacct cgccgcccac cccgggctga ccaccgccgt gtgcgtgtgc  21600

gccgacctcg gcgagaacta cgcgcgcacg gtctacgacc ccgactggct ggcgccgctg  21660

cgcctcaccg acgaccccgg actcctgcgg tcccgcctgc gcggggcgcg cttccaccac  21720

gccgaaccgg acaccggaca ggagagcacc ccatgaccgc catccgcgag atccggctca  21780

gcgagccgga gtccgcgcag gccgcgctgc tcgcgctgga gtgcgcgcag cgctacgccg  21840

aacccgactc cgccgacttc ctcgccgacg ccgccgtgct ggcccacgac ctgccccggg  21900

cggtgcgccg ggaggtcgag cgcgcccgcc tggacgaccg gctgcacgcg ctggtcgtgc  21960

gcggcaacga cgtcgaccag gacgcgctcg gcccgacccc gccgcattgg cggcaggcgc  22020

gcaccgccgc gtcccgccgc tacggcttcc tcctggtgct ctacgcctcg ctgctcggcg  22080

acgtggtcgg ctgggccacc cagcaggacg gccgcgtggt gaccgacgtg ctgcccatcg  22140

aggggcagga ggactcgctg gtcagctcca gcagcagcgt ggagctgggc tggcacaccg  22200

aggacgcgtt ctccccctac cgggccgact acgtgggcct gttctcgctg cgcaaccccg  22260

actcggtggc caccaccgtg gccgggctgg accccgacct ggtcgggccg gccgtggtgg  22320

acgtgctgtt cggcgagcgc ttccacatcc gccccgacaa ctcccacctg cccacgcaca  22380

acagcggcgg ccggttgagc gactacttcg ccggcatcgt cgaggcggtg gagaacccgc  22440

gcgcggtgtc gatcctgcgc gggcaccgcg acgcgccgca gttgtgcgtg gacagcgact  22500

tcaccaccgc cgtggacggc gacgccgagg ccgcgggcgc gttggacacg ctcatcaagc  22560

acctcggcgg cgcgctgtac gaggtggtgc tgggcccggg tgacgtggcg ttcctggaca  22620

accgcaacgt cgtgcacggc cgccgcccgt tccgggcccg gttcgacggc acggaccgct  22680

ggctcaagcg catcaacgtg accgcggacc tgcgcaagtc gcgggcggcg cggcgcgacg  22740

cccaggcgcg cgtgctgggt gaggcgtgat ggtgcgcgac ctgccggccg ccgcgctgga  22800

ggactggttg cgcgagcggt acttcaccgc ccgcgtggac gtctccagca gcggtgtggc  22860

cgaccaccgg ctggcggacc tgcggcggtt gggcgggatc accgtcgagg agctggacgc  22920

ggtggtgttc cgcgacgggc cgtcgctggg cgcggagcgg ctgcgggcgg cgctggcgga  22980

ccggctgcgg cccggacccg accacgtcgt gatgaccgcg cacgggtcca gcgaggcgtt  23040

gttcctggcg atgaccgcgc tggtgcggcc cggtgacgag gtggtggtgc ccgaccccgc  23100

ctaccactcg ctgtcggcgc tggcgcgggc gtgcggggcg gtgctgcggc cgtggccggt  23160

gctgggcgcg gcacccgacc cggcggacct gcgggcgttg ttgacgcccc gcacccggct  23220

ggtcgtggtg aacttcccgc acaaccccac cggggtgacc gtggacgcgg cggtgcaggc  23280

cgaactgctc gacgtggtcg ggcgcagcgg ggcgtacctg ttgtgggaca acgcgttccg  23340

cgacctggtc tacgacgcgc cgccgctgcc ggagccgacc gcgctgggcg ggcgggtgct  23400

gtccaccggc acgctgtcca aggcccacgg gctgcccggc ctgcgggtcg ggtggtgcgt  23460

gctgcccgcc gacctcgcgc cggagctggt ccgcgtccgg gactacctga cgctgagcct  23520

gtcgccgctg accgaactgc tcgccgcggt cgccgtggag cacgccgacg agctgatcgc  23580

gccccggctg gcggaggcga ccgccaaccg gcggcggctg ctggactggg ccgccgcgca  23640

cggcgtggac tgccccgcgc cgggcggcgg ggtgaccgcg ttcccccggt tcccgggggt  23700

ggccgacgtg acgccgctgt gcgaccggct gatgtccgaa cacggcgtcc tgaccgttcc  23760

gggcggttgt ttcggattcc ccgatcgaat gcggatcgga ttcggctgcg accccgcggt  23820

gttcgcggcc gggttgaccg cgctgggcgc cgtgctggcg gaaaaacggt tgccggcaaa  23880

actgtgactg gttgactacg cagcgcaaca tcgccgtttc gagaggaatc accgtggcag  23940

ccatcgagaa cgcgccacgc aggctgcgcg acaacaggga cttccggttc tggtggggcg  24000

gcaccgtgct gtcggccatc ggcgacgagg tcacgctgat cgcgtttccc ctgctcgtgc  24060

tgttcctgac cgggtcgccg acgcacgcgg gcctggtcgg cggcgtggcg gccgtgccgc  24120

cgctgctgct gagcgtgccg atcggcgtgc tggccgaccg gacgtcccgg cgggcgctca  24180

tgctcggcgg ttcggtggtc agcgcgatct ccatcacgtc cattccggtc gtgcacctcc  24240

tgggtgaact cacccttccg catttgtacg tggtcgcatt tgtcaacagc gttgcggcga  24300

ccgtgtaccg gatcgccgac accgccgcgc tgccccggat cgcgggcgag gagaaactgg  24360

gcgaggcggc gtcccagagc gagacgatct ggggcatctc ggccatcgtc gcgccgccgc  24420

tggccggtct gctgttcgag accgccgggc cgacctcgcc gttctggatc gacgccgtgt  24480

cgttcgtcgc gatcatggtg tgcgtcctgg cgatccgggc ccggctcggc gcggacaagc  24540

cctacccgga ggtgtcctgg cggcaggacc tcaccaccgg cgcgcgcgtc acgttgagcc  24600

ggccgctggt gcgggccctg acgatcctga ccgtcgcggg cgacttcctg ttcgcgggca  24660

tcggcctgct gctgatcgtc atggtgcggg agaacggcgc gtcggggctg gagaccggca  24720

cggtgttcac cgccgccgcg gtgggcggca tcctcggctc gatgctcgcc ggccgggtcg  24780

aggaccggat cgggatggtc ccggccgtgc tgaccaagca ctggctgacc gccgcgctgt  24840

tcccgctgct gctggtggac ctgcccggct gggccaccgg gctggtctgg ggcctgatct  24900

cgttccagat ctcgatcctc aacgtgatcc agatgaagta cctgatgagc gtcatcccca  24960

acagcaagct cggccgcgtc gaggggttcc tgacgttcat cgagcagggc agcctgccgc  25020

tgggctacgc gctcaccggc gtgctgctgg gcctgctcgg caccacgtcc acgctgctgg  25080

cctacgaggc cgtgctgctg gtcctggccg tcttcgcgac ggtcagccgg ggcctgcgca  25140

cccccgcgca ccccgacgag cccgcccgat catcgggctg acgccaggag agctgatgac  25200

ccaggtcgac ttcacccggt gggacctgcg caccgacgcc gagaagcacg ccaccccgac  25260

cgtcctgagt ggaccgccgc cggcgtggtc gccggacacc acgttggcgc ggctggtgct  25320

ggaccaggcc gaccgcaccc cggacgcgga cgcggtccgc atcggcccgg acgccctgac  25380

ctaccgcgag ttggccgccg gcgcgcggcg ggtcgcggcc tgggtggccc ggcagccgca  25440

caccgggccg ccgcgcgtcg gcgtgctcgg cgagcggtcc cttgcgacct acccggtgct  25500

gctgggggtg ctgctggcgg gcggcgcgta cgtgccgctg gacccggcgg cgccgcccgc  25560

ccggctgcgc gcggtgctgt cccgggccga cgcgcacgcc gtggtgacga ccgcggagag  25620

ctgggcgttg ttggagcagc cggggctgcc cgcgctgctg accgaccagc cgctgccgtt  25680

ccagcggtcc aaggtggaca gcgggcgggt cgcggtgctg gcgggcctgc ccgacgcggg  25740

cgagccggtc gggccgacgc cggacgacgt ggcctacgtg atcttcacgt ccggttcgac  25800

cggcacgccc aagggtgtgg tggtgcagca ccgggcggcg gtgaacctga cctgctgggc  25860

ccgcgacctg gtgccgatgg ggccgggcag ccgggtcacc cagaacgcgt cgctgcactt  25920

cgacgcctcg gtgcaacaga tcttcccggc gctggcctcg ggggcgacgc tgttcccggt  25980

gccggagcgg gtgcgactgt ccgggccgga gctggccgcg tggctggccc ggcaccggat  26040

cacgcactgg gactcggtgc cctcgctgtg gacgcccgtg gtggagcacc tggccgaccg  26100

gatcgccgcg ggacaacggg tgctgcccga cctgcgggcc gtgctgctgg ccggcgagcc  26160

gctgccggcg cggcaggtgg accggtggcg gtcgtgggag caggggcacc ggctgttcaa  26220

cgtctacggg cccaccgagg tgaccgtgaa cgcgaccgcg ttcgaggtga ccgggccggt  26280

gggcgcggtg gtgccgatcg ggcggccgtt gccggggatc accgcgtccg tgctggacgc  26340

gcacggcaac ccctgcccgg tggacgccga cggtgagctg ttcctgggcg gggtggggct  26400

ggcgcgcggc tacctggacg acccggaggg caccgcgcgg tcgttcgtgg agcgcggcgg  26460

cgagcggttc taccggaccg gtgacgtggt gcgggtcggc gcggacggcc tgctggtgtt  26520

cgtgggccgc cgggacgacc aggtgaagct caacggcgtc cgcgtcgagc cggccgagat  26580

cgagcacgcc ctgctggcgc accccggcgt gaccgaggcg gtggcggtgg tgctgcgcga  26640

ggagggccgg gcggagctgg tggcctgcgt ggcctcggcg gtcgagctgt ccacggagga  26700

catccgggcc gggctggcgg aagagctgcc ggcggcgctg gtgccgtcgc gggtggtggt  26760

cgtggagtcg ttgccgcaca acgccaacgg caagctggac cgggccgcgt gcgcggagct  26820

ggcgcgcgac ctgtccggcc cgtcgggcgg cgccgggccg ctcggggcga cggcggcgac  26880

gctgctgggc atctggcgga gcgtgctggg ccgtgacgac atcggcccgg acgacgagtt  26940

cttccaggtc ggcggcaact cgatcaccag catccggctg cgccgggagt gcgtggaggc  27000

ggggttgccg atccgggcgg tggacgtgtt cctgcacccg accgtgcggc ggctggcccg  27060

gtacgtggac gacaaccgga ccacgctggc cgcccgcgcc cgtcccgcgc cggaggagtc  27120

gccgaccgac ggcgagttcc ccctgctgcc cgcccaacgg ccgctcgccc tgacggcgct  27180

gctcagcgac ggcggcgcgc agcgcggtct ggtgcaggag accgtcacct accgggtgcc  27240

gctggacgtg gacgccgtgc gcggcgcgct ggaggtgctg ctggagcggc acgaagtgct  27300

gcggacggcg gtcacgccgg ggctggcgca gcgggtgctg ccgaaggtgc cggtgccgtt  27360

ggaggtggtg gacctgaccg gcgtggccga ccagtggggt gcggtgctgg aggccgccga  27420

ccgggactac gcgaccccgt tcgacctggc cgagccgccg ctggtgcggg tgcgggcgtt  27480

cgaccggggc gaggtgttct cgctgacctg gaccctgcac cacgtcatct cggacgggtg  27540

gtcgtgggag atcgtgcaac gcgagttcga ccggctgcac gtggccctgc gagcgggccg  27600

gttccgcccg ctgccgccac cggtgctgcc cctgcgcgcg ctggcccgcc gcctggggtc  27660

gggcgggacg ccggacccgg agtgggtggc gcgcctggcc gccacgcccg ccctgctgct  27720

gcccgccgac ggcagcggcg tcggcggtga gcacatcgag tggccgatcg accccgggac  27780

gcaccgcgag ttggccgccc gcgcgcaggc cgcggaggcg tcgccggccg cgatccacct  27840

cctcgccttc accgaggccc tgcggcgggt gtgccggcag gactcgttcg ccgtcggcgt  27900

cgtgtcgtcg ggccgcaacg tggacgtgcc gggcgtcgag gaggccgtcg cgtgcctggc  27960

ccggaccgtg ccgctgccgg tggacgccgt gggcggcgcc gaggcccgcc tggcgcggct  28020

gcaccgcgac ctcgccgtgg tggtcggcat ggacgacgtg gacaccgacg tgctcccggc  28080

cgacgtgccc gccggcgtcc gccacccggt ggcgaccttc gtcttccaga actacccgga  28140

cgccgccgtg ccgcccggcc accggccgct gcccgaggtg cccgaggagg gccgctggcg  28200

cgaggccggg tccgacccgc tggcgctggt gtgcttcgag gacgacggcg tgcccggctg  28260

ccggctggag ttcgacaccg ccgcggtgtc ccgggcgacc gccgagctgg tcgccaggga  28320

ggtccgccgg gcccagaacc gactcgcgaa ggggatgcag ccgtgaccgc ggacgccgcg  28380

ctcgaacccg acgaacgggc cgcctggctg gcctacaacg acaccgccga ggacttcccc  28440

ggcccgcacc tgctcgcccg cctcgacgcc gtggcgcgcg agcaccccga ccgccccgcc  28500

gtgcacgccg tcgacggcgt gtggacctac cgcgaactgc accgccgcgc cgacgcggtg  28560

gccgccttcc tggccgcgcg gggcgtccgg ccgggttcgg tggtggcgat cgcggccacc  28620

cgcgcgctcg ccccgtacgc cgcgctgctc ggcgtcctga aggccgggtg cgcctacgtg  28680

ccggtcaacc cggacgaccc cgccgaccgg gtggcgttcg tgctggccga cgccggcgcc  28740

acgccgctgc tgctggacac cgacccggcg agcctgcccg ccgcgcccgc gccggacgtg  28800

ccgcacgagc cggaccgggt ctgctacgtc atctacacct ccggcagcac cggccgcccc  28860

aagggcgtgg tgatggccga acgcgccgtg gacaacctca cgcactgggt ggtgcggcgg  28920

cacgacgtgc gccccgacga ccggctgggc cagaccgcgc cgctgacgtt cgacccgtcc  28980

gtgcaacagg tcttccccgc ctgggcgacc ggcgcgtgcc tggtcaccgt gcccgacgac  29040

gtccagcgcg acccggccgc cttcctggac tggctgcgcg ccgagcgcgt cacccacctg  29100

gacctggtga cctcgcactg ggtccacctg ctcaacgccg ccgaggcgcg cccggcggag  29160

ctgccggacc tgcgctggat catcatcggc ggcgagacgt actactacca ccagacccac  29220

cgctggcacc gggtcgtgtc ctcccccgcg cggctgaaca cgatctacgg ccccaccgag  29280

gcggccgtca acgccaccga gcacctcacc gaacccgacc tggaccacgg ccaggtgccc  29340

atcggcgtcc cgctgcccaa ctaccgcctc tacgccctgg acgacgacgg gcggctgtgc  29400

ccgccgggca tcaccggcga gatccacatc gccggcgccg gcctcgcgcg cggctaccgg  29460

tccgccgagg ccaccgcgaa ggcgttccac gagctggaag tccacagtgg acggaccgag  29520

cggctgtacc ggaccggcga cctcgcccgg ctggtgcgcc acgccgaccg gtgggcgctg  29580

gagttccagg gccgggtgga cagccaggtc aagatctccg gctaccgcgt cgagctggag  29640

gaggtggacg cggcggtcaa ggccgtgccg ggcgtgcggg acgcggccgt cgtggtgcgc  29700

ggcgaaccgg ccgagcagct cgtgtgctgc tacgtcggcg acgtgccgcc ggaccggctg  29760

cggtcgcgcc tgaccgagcg gttgcccgcc tacctggtgc cgcacctgct ggtgccggtg  29820

gaggcgttgc cgttcacccg caacgggaag atggacaccg ccgagctggc cgagctggtg  29880

cggcggttcg cgcgcgactc cgccggccgc gcgccgcgcc ccggcgtgga gtccgtggtc  29940

gcggcggtgt gggccgaggt gctggacctg ccggaggtgt cggcggacgc ggacttcctg  30000

ggccacggcg ggtcgtcgct gctggcgttc cgggtcgtgg accggctgcg ccggcgcggg  30060

atccgggtgc ggccggccga cgtgctgcgc gagcgcacgg tcgcgggcct ggccgccgtc  30120

gccgaagagg acctggtgct gacgccctcg acgcggctgg cgctgcgccg gccgggcggc  30180

aacgccaccc tcgacatcgg cctccccgcc gacgtgcccg ccgaacgggt ccgcgccgtg  30240

ctggaggaca tcgtgcggcg gcaccccgtg ctgcgcgccc ggatcgacga cgacggcccg  30300

cgcgcggtgc cggtggaccg gttcgagctg cacacccccg acggcccggt ggacgacgcc  30360

aaggcccggc tcgccgagtc caccgacctg acgaccgggc tgcccacggc agccgcgctg  30420

gtggcgggcc ggctgctggt gtcgatccgg cacgaactgg tcgacggcgc ggcgctgcgc  30480

cgggtcgccg aggaggtcgc ggccggcctg ggtcgcgcgc cgcggccccg cccggtcgtg  30540

cccgtggccg accagccgct gggcggaccg gccccggacg ggctgcgcgg gcacctggtc  30600

cgcttccttg aggccgagaa ggccgcgttg gccgcgctgc cgcgcgagca ccgcgaccgg  30660

gtggtggagg tggacctggg gcacgcgccc gacgcgctgc tggacacccc gccgacccgg  30720

tggcacgccc gcctggtcgc cgccgccgcg acggccgcgc ggtcctggct ggggctggtc  30780

gacgtgccgg tgggcgtgcc ccggcactgg ccgggcgcgg gcgggtcggt cgcgaacctg  30840

gccgacgtgc tgcccctggt cgtcgcggac gacgacgagg ccgacgcgca gtggcggcgc  30900

ttcgccgacc cggccgtgca ctggggcgcg gcgctgctgg acgcctgccc cgacctcgcc  30960

gacgactggc ccgcgccccg gatcgcgccg cagggctcgt tccggctcgt ggtgaccgcc  31020

gacgacgaac cgctcgcgcc cgacctcccg ctgcacgaga gcccgaccgc gttcgacccg  31080

gcgtcggcgg gcgcggtgga gttcgcggtc gtcgcgggcg accgcctgcg gctgcacgtc  31140

accggctggg acctgcccgc cgacgaggtc aaggccgtgg ccgccggctg ggtcgaggcg  31200

ttggcgggtg agcggcggtg acgccggacc cgcactggct gcgcccggtg ggcgggcggt  31260

ccggcggccc ggtgctgctg tgcctgccgc acgcgggcgc cggcgccttc gcctacgccg  31320

gctgggaccg gcaggacgcg ttcgacgtcg tggccgtgca accgcccggc cgggaggacc  31380

ggttcgccga gcagccgatc accgaccccg agcacctcgt ccgcgagatc gccgacgcgc  31440

tgggcgacct cgccgagcag ccgctggcgc tgttcgggca cagcctgggc gcgctgatcg  31500

cccacgacct ggcccgcgag ctggaccgcc ggggcgcgcc cgacccgctg ctgctcgcgg  31560

tgtccgggca cgtgccgccg caccggctcg accccgaccg ggcgcgcgac cggtccgacg  31620

ccgaactggt cgagcacgtc cgcgaactcg acgacgaccc cctggacgac gtgctggccg  31680

acccggagtg gcgcgcgatg ctgctgcgcc cgctgcgcgg cgacctggcc ctgcacgacg  31740

cccacaccca ccgccccggc ccccggctgc gcgtgcccgt gctcgcgctg accggcgcgg  31800

acgacgacgc caccccggcc gaggacacgg cggcgtgggc ggagctgacc gagggcccct  31860

tcgcccaccg ggtccacccc ggcgggcact tctacctccg cgccgccagg tcggccgtcc  31920

tcgacgacct cgcgcaccac ctcgaaggag cgtggcgacc atgaccaccg agaccccagc  31980

gaccaccggc gccccggcga ccaccggcgc ccccgcccca ccgggccggg ccgagatcgt  32040

cgccgccgtg ctgccggtat tcgccgaggt gctcgacgcg ccggacctca cccccgacag  32100

cgacttcttc gtccacggcg gcaactcgct gctggccatc cgggtcgccg ggcgggtggg  32160

ccgcaggctg ggccggcagg tcccgcccgc cggcgtgctc aagcacccga ccccggacct  32220

gctggccgcc cacctggagg aggagttccg cggcggcggc gcgccgccga tccccgcgcc  32280

gcgcgccggg gcggaggccg accgccggcc gtccaccgcc caggaacggg tgtggctgct  32340

gcaccagctc gaccccgacc ggctcgacca cctggtcacc gtggcgctgg acgtggccgg  32400

gacggtggac ccggcggcgt tcaccgcggc gtggaccgcg gtcgtgcgcc ggcacgaggc  32460

gctgcgcagc cggttcgtca aggccgacga cgaccgggtc gcggtcgtcg tggacgccga  32520

ggccgcgccg gagatcagcg tgctggacct cgcccgcttc cccgccccgg tgcgcgaccg  32580

gctcgccgag gaacgggtcc ggctcctgcg caccaccccg atccggctgg acaccggccc  32640

gctcgcccgg ttcgcgctgc tgcgcctggc cgaccggcgg taccggatcg agctggccgt  32700

gcaccacatc gtgtgcgacg gctggagcct ggacaccctg ctcgccgact tcctcgacgc  32760

ctacggccgc gcgctggcgg gccgctcccc cgcgctgccg ccgccggcgg tgggcttcgc  32820

cgactacgtg gcgtgggagc gggacgtgga gtcctcgcgg tggccggaca tggccgtgcg  32880

gctggcccgc cggttcgccg accggcccgc cgacctgccg ctgccggtgg acccggtgga  32940

cgtgccggcg cacgaggacg gcgacgacgt gaccgtgcac gccccgcccg gcctcgcggc  33000

ggcggtggag cgggcccgga cctccttcgg gcacaccgcg ctgacgttcc acctgaccgc  33060

gctgggcgtc ctgctcgccc ggatcaccgg ggtggacgac ctggtggtgg cggtgccggt  33120

cgcgggccgc gcgcagaccg agcacgagga cctggtgggg ctgttcgtca acacggccct  33180

ggcgcgggtg cggctgggcg gcacctcgga cgtgcgggtg ctgctggagc gcaaccgcga  33240

cgaggtggac gagctggtgg actgccagac cttcccgttc gaccgcctgg tggacctgct  33300

cggcgcgcgc cgcgcgggca ccagggtgcc gctggcccgg gtgtcgctgg cggtgcagaa  33360

cttcgacgac cccggcacgc ccgcgcccga gctgggcttc acctggcagt tccgcgaccc  33420

gccggagcgg cagagcaagt tcgacctggc cttcaccgtc tccgacaccg acggcctgcg  33480

gttgacggtc acctaccggc cgtcgctgtt ccgccgggcc accgtcgccg cgtgggccgg  33540

ccagtacctc gtggcgctgg agcacgtcgt gcgcggcgtc gccgacccgg aggggagcgc  33600

gcggtgaagc tcaaccggca gcacgagttg ttccgcgagt ccgtgcggat ggtgctcgac  33660

cgcgagtgcg tcgagctggt cgacgactgg gagcgcgacg gcgtcatgcc cgtgcaccag  33720

ctgtgcaaga ccctggccgc cgaagggctg ctgggcctga ccatgccggt ggaggacggc  33780

gggctgggcc tggacctggg ctactcctac gtgtgggcgc aggagctggg ccgcgtcccg  33840

gccggcgcgc ccgcgatggc gctgtccgtg cagaccgaca tcgtcgcgcc gctgctggcc  33900

cgcgccggca cgcccgaggt gcgccgggac gtgctgcggc cggccatccg gggcgagctg  33960

gtggcggcgc tggccgcgac cgagccggcg ggcgggtccg acctgggcgc gctcaccacc  34020

accgccgtgc gcaccgagcg cggcttcacc gtcaacggca ccaaggcgtt catcaccaac  34080

gggtcggtcg cggacttcgc cgtggtgctg tgccgcaccg gcgaggcggc cggcatcggc  34140

gacctggcgc tgctggtggt gccgaccaac ctggccgggg tgcggcaggt ccgccacacc  34200

ggcaagctcg gccaccgctc gtgcgaccac ggcacgctga ccttcaccga cgtggaggtg  34260

cccgcggcct acctgctggg cgaggtcggc gagggctacg agctgcagac ccgcacgttc  34320

acccgggagc gctgcttcct ggccgtggtc gcgctcggcc aggccgaacg ggtgctgcgc  34380

gcgaccgtgc accacgcgcg ccgccgccgc gtcctgggcc gcgcgctgac cgaccaccag  34440

gcgatcgggt tccggctcgc cgaactcgac gccgaactcg acctcgtgcg cagctacgcg  34500

ggcgaggcct accaactgct cgccgacggc gcgcagtgcc tgcgcgaggc cagcatcgcc  34560

aagctgcgcg ccacccgcct gctgcgcgag gtcgccgacg tcgggctcca ggtccggggc  34620

gcggcgggct acctgggcgt ggacgacgtc gagcgcacct accgcgacgc ccgcgcgggc  34680

agcttcgcgg gcggcgcgga cgaagcgctg ctgcacctca tcgcgggcca cctgaccggc  34740

accgaacagg agtgaccatg acgccgagcg aagaactgct gttcctggac cgcgagaccg  34800

tgcgggcctg cgtcgcgggc gtggaccccg tcgaggtggt cgagtccgtg ctgcgcagcc  34860

acgccgccgg ccgcaccacc ctgcccgccg agggctacct gccgtgggag aacgaccagg  34920

gcgcgtactg ccggtccatc gccatgctgg gcgcggtgga cggcgaacgc ggccccacct  34980

acggcatcaa gctgatcaac gccgccgtct ccaacccctc gatcggcctg gaccgggccg  35040

gcggctgcgg gttcctgttc gacccgcgga ccgcccggcc cgtggtgctg gcggaggcgg  35100

cctacctgtc gggactgcgc accgccgcct acacgatggc gagcctgcgg cacctggggc  35160

cggtggggtt cgacgcggtg agcttcatcg gcacgggggc gcaggcgcgc gtgcacgccg  35220

cgctgctggc ccgctacttc ccggccgtgc gggacctgca cgtgttcgac accgagcgct  35280

ccagggccga ggcgttcacc ggcgcgtccg ggcacaccgt gcacgtgcac gacaccgccg  35340

aggccgccgt gcgcgcgagt cacgtcctgg tcaccctgac caccgtcgac gacgggtaca  35400

tcccgcacga ctggttccgg cccgggtcgt tcgtcgcgca cgtgtcgctg gacgacctgc  35460

tgcccgaggt gttcttcaag tccgaggcgc tgttcgtgga cgacctggag ctgatccggg  35520

agaacccgcg ccgggtgctg ggcgcgctgc tggccgacgg cgacgtcccg gtcaccgggt  35580

cgctgggcgg ggtgctgacc ggggcggtgg ccccggtgcg gccccgggac ggggtggtgg  35640

tcagcaaccc gttcggcatg gccgtgctgg acgtgggcct gctggcggag gtcgccgcgc  35700

acgcccgctc cgccgggctg ggcacgaccc tcgacctgct gggcgcggcc cgatgaccgg  35760

cctgtactcg ctggcggacc tgtccccggc ggacgtcctc gccctggcgg accggtcggt  35820

gcagctgcac cgcgaccgga ccgcgcacga ccgcccgctg accgacctgg tggtgggcac  35880

cctgttcacc aagacctcca cccgcaccag gaccgcgttc accacggcgg cgctgcggct  35940

gggcgcgtcg gtggtcgcgt tcggcccgga cgagctgcag accgccaccg gcgagtccac  36000

cgcggacacc ggccgggtcc tggcgtccat gctggacggg ctggtcgtgc gcaccgccgg  36060

gccggtcgcg cggcaacggg agttgtccgg cggcggcgtg ctgccggtgg tcaacgccat  36120

gagccgcgag gagcacccca cccagggcct gaccgacctc gcggtgctgc gccaccactt  36180

cggcgacctg gcgggcgtgc gggtgctgta cgtgggcgag ggcaacaaca ccgccgccgc  36240

cctggtgcac gcgctggccg ccgtcccggg ctgcgagctg gtgctggcct gccccaaggg  36300

ctacgggccg cgcgaccccg gcccgtggcg ggaggtcgcg gacctcgcgg aggtcaccgg  36360

ggacgtggac gtcgtctaca ccacccggtg gcagaccacc ggcacggcca aggccgaccc  36420

ggactggcgc gaggcgttcc ggcccttcca cgtggacacc gcgctgatgg accggtggcc  36480

ggacgcggtg ttcctgcacg acctgcccgc ccaccggggc gaggaggtgg ccggcgcggt  36540

gctggacggc gcgcggtcgc tggcctggac gcaggccgcg atgaaggcgg cgagcgcgat  36600

ggcggtgctg gagcggttcg tcgggggtcg tcgtgcttga cctctccccc gcgcagcgca  36660

gcctgtgggt gctgcaccaa ctggacgaca ccgggttcac gctgtcgtcg gcgcaccggc  36720

tgcgcgggcc gttcgacctc ggcgcgttca cggcggcggt ggacgcggtg gtggcccggc  36780

actcgccgtt gcgcacccgg ttcccggtcg ggacggacgg cgggcccgac cccgtggtgg  36840

acccgccggg gccggtggtg gtcgaggcgg tcgcggcgga ggggttcacg gccgcgcacg  36900

ccgaagccgc gcggttctgc gcccggccgt tcgacctggc gcgggagtgg ccgctacggg  36960

tgctcgtggt gcgtctgtcc acagaggacc atgtggtggc gttggcggtg caccacatct  37020

cctgtgacgg cgtgtcgctg gggctgttgc acgacgagct gtcccggctc tacgacggtg  37080

cggagctgcc gccggtcgcc gaccaccggg agctggtggc tcggcgcgcg gtggacccgg  37140

cggcggtggc ccggtgccgg gaccggctgg cgggcgtgcc gccgctggcc gccgaccggc  37200

ccgcggtgcg gtcgggcaag ggcgaccagg tgtggttcac cgtgcccgcc gacctgaccg  37260

gcgcggtgcg ggcgtgcgcg cggcggcacc gcgtcaccgc gttcatggtg ttgctggccg  37320

cgttccagct cgtcctgcac cggcggaccg ggcagaccga cttcgcggtc ggcgtgccgg  37380

tggccgggcg cggcgacccg gacagcgaga acgtcatcgg cctgttcacc aacaccgtcg  37440

tggtgcgggc cgacctggcc ggcgagccgg gcccggcgga ggtgctgcgc cgggtgcggg  37500

aggccgcgtt cgacgcgttc gccgaccagg acgtcccgct gggcgcggtg gtggcggccg  37560

tgggcgaacc gcccgacccg gcgcgcaccc cgttgttcca ggccctgttc accttccagg  37620

acgcgccggt cgggcggctg gcgctgcccg gcgtgcggtg cgtggaactg gacctgccca  37680

ccggcgccgc cgcctccgac ctggagctgg agctggtgcg cgacggcgac gagctggccg  37740

ggtccctgga gtactcgacc gacctgcacg acagcggcac ggccgcggcg ctgaccgccg  37800

acttcctggc cgtgctggac gagatcaccg cggaataggg ggaaacgtgg acacgtacct  37860

ggtggtcgtc aaccacgagg agcagtactc ggtgtggccg gccgaccggc cgctgcccgc  37920

cgggtggcgt gccgagggca cgtccggcga caaggagcag tgcctcgcgc acatcgagac  37980

cgtgtggacc gacatgcgcc cgctcagcgt gcgccgccgc gcggaggcgg tgtgaccgcg  38040

ctgcaccgcc tcgaccagct cgccggcgcg cggcccgacg cgccggcgtt gctggacgag  38100

gcggagacgg tgtcctacgg gcggctgtgg cgcgagctga ccggcgtggc gggcgcgttg  38160

cgggcggcgg gcgtgcggcg cggggaccgg gtggtggtgc cggcggaccg gacgtggcag  38220

ggcatcgtgt cgatgctcgg tgtgctgcgg gcgggggcgg cgtacgtgcc ggtggacgcc  38280

ggcgacccgg tcgagcggtt gcggcacgtc gtgcggacgg cgggcgcggc gtgggtgacc  38340

gggcgggcgg aggcgctggc ggcgttgccg gacctgggcc tgcacccgat cccgttcggc  38400

tcggccccag actcggcctc acgctcggcc tcaggctcgg actcgggttc gcactcggct  38460

tccggaggcg tcggcgggtt gcccgatccg gaggacttgg cgtacgtgat gttcacctcc  38520

gggtccacgg gcacggcgaa ggcggtcatg gtgccgcacc ggtcgatcgc gcacgccgcc  38580

ccgtcgctgg cgcggcggtg cgggatcacg ccggacgacc ggttcctgag ctgggcgtcg  38640

ctcgtgtggg acaccagcgg cgaggagctg tactcgacgc tgctgtccgg cgcgggcctg  38700

gtgctcgacc gcgaggccac ctccgggtcg gtcccggcgc tgctgcgcgc ggtcgaacgc  38760

cggtcggtgt cggtcgtgga cctgccgacc gcgttctgga accaggtggt cgactacctg  38820

gagacgaccg gcgaggcggt gccggagtgc ctgcggctgg tcgtcgtggg cggcgaggag  38880

gtgcgggcgc ggcaggtgcg ggtctgggcc gagcgcgcgc cggacgtccg gctgctcaac  38940

acctacgggc agaccgagac cgtcatggtc acccacgcgg ccgacatcgg cggtctcgcg  39000

ccgccggacg ggggcgcggt gccgatcggg cacccgctgc cgcacgtccg ccagcacctc  39060

gaaccggtcg gcgacggcct gttcgagctg cacgtcggcg gtcccaccct cgcgtggggc  39120

taccgggacc ggcccgcggc gaccgccgag cggttcccgc ccgacgagcg cgggcggcgg  39180

ttccgcaccg gggacctggt gcgggtggcc gacgacggcg cactggtgtt cgtgggtcgg  39240

gcggaccggc aggtcaaggt gcgcggggtg cgggtcgagc cggccgaggt ggaacgcgcg  39300

ctcatggcgt gccccggggt gaccgcggcg gcggcgttcg tggtggacaa cgcgtcggac  39360

ggcgtcctgc tggtcggcgc gttcgtgccc ggcgacggcg acgccacgcc cgcgacggtc  39420

gcggcggccc tgcgcaccag gttgtcgccc gcgctgctgc cgcaccgcct ggtgtccgtg  39480

cccagcatgc cgctgctcac cacgggcaag atcgaccagg ccgcgctggt ggagcggttc  39540

gcgcggtccg acgtcgcgcc gggcgccggc ctggcggggc agctcgcggt ggtgttcagc  39600

gaagtcctgg gcacgccgtg cgcggccgac gacgacttct tcgaccaggg cggtgactcc  39660

gtggtcgcga cccggctgct gacgcgcatc cggcgcagct accgggtgga gctgacgttc  39720

cgcgacgtgt tcgaccaccc gagcccgacc gcgttggcgg gcctgatcag ccggaccccg  39780

aggtgagcgc ggtgcccgtc cagccgcacg agcacgtccg gcgcacgccg gtggagccgt  39840

cctggcggcg gttccccggc tggcgggacg tgacgcggga gcagtggcgc gacccgcggt  39900

ggcagcgcgt gcactgcgtc cggaacaccc ggcagttgcg cgcggtcgtc ggtgacctgc  39960

tcgacgagcg gttctacgac gacctggcgg ccgaccagga gtcgttcgcc acgatgtcga  40020

tgctgctgcc cccgcagatg ctcaacacga tggtgcccga gggggcggcg gacttcaccg  40080

gggcgttcta cgccgacccg gtgcgccggt acatgctgcc ggtgcggtcc gaccgcgacc  40140

ccgagtggcc gagccacccg tactcgtcac gggactcgtt gcacgaggcc gagatgtggg  40200

tggtggaggg cctgacccac cggtacccga cgaaggtgct ggcggagctg gtgtccacgt  40260

gcccccagta ctgcgggcac tgcacgcgga tggacctggt cggcaactcg accccgcagg  40320

tgcgcaagca caagctggag ctcaaaccgg tggaccggca ggaccggatg ctggactacc  40380

tgcgccggac gccggccgtg cgggacgtgg tggtctccgg cggtgacgtg gcgaacgtgc  40440

cgtggccgca actggagtcg ttcctggcgc ggctgctgga gatcgagacc gtgcgcgaca  40500

tccggttggc caccaaggcg ctcgccggcc tgccccagca ctggctccaa ccgcaggtgg  40560

tggagggcat gtcccgcgtc gcccgcacgg ccgcgagccg gggcgtgaac ctggccgtgc  40620

acacgcacgt gaaccacgcc cagtccgtga cgccgttggt ggccgaggcg gcgcgggcgc  40680

tgctggacgc gggggtgcgg gacgtgcgca accagggcgt gctgatgagg ggcgtgaacg  40740

cgacgccgga cgacctgctg gagctgtgct tcgcgttgca gggcgaggcg aacatcctgc  40800

cgtactactt ctacctgtgc gacatgatcc cgaacgccga gcactggcgg acgtcggtgg  40860

ccgaggcgca ggacctgcag gcggcgatca tgggttactt acccggctac gcgacgccgc  40920

gcatcgtgtg cgacgtgccg tacgtgggga agcggtgggt gcaccaggtg gtcgagtacg  40980

accgcgagct gggcgtctcg tactggacga agaactaccg gacgggtatc gaatcagacg  41040

acccgaacgc cctggaccgc cggtacccct actacgaccc gatctccacg ttgggcgaga  41100

cgggccggcg gtggtggcgc aaacacgaac gagcctgacc cgcacgcgcc ccgacggctc  41160

aacggtcgtc ggggcgcggc accggcacgg gcgggcgcgg ggtgggccgg cctggcgtgc  41220

gcgggcctgc ggcgagtgtg ggcgtgcggg tgggctatgg cggagcggtg gactcagcgg  41280

taggcggtca ggccgtcttc cagttcttcg tcgtcgccgt cctcggcacc cgccagcgcc  41340

tgctgcaacg cgaacgtccc ctggtaagcc cggatccgcg gccacaggtc ccccgccccg  41400

agcagcgcga ccacccgctc caccagctca ggcccataac tggcccccac cgccgccagg  41460

tcctccgccg ggtcgcccac cttggcctcg tcccagtcca cgatcccggt cagccgcggc  41520

agctcctcga cctgctgcca caacacgttc tccccgccga gatccccgtg caccaacccg  41580

gtggcgacgt ggtccatcgc cacggccgcc gccaactcgc gctcggcccg cgcccggccg  41640

tcctccgaca tcagcgggaa cagcgtcgcc cggacccgcc cggcgaaccc gcgccaccgc  41700

ccggcgtcgg cgaccggcag caccagccgc aacttctcca catcagcgcc ggccatcgcc  41760

cgcaacaccc gcgcgaactc ggcggccacg acgtcgatca cctcgggcga cgtcgcgtcc  41820

ccccgctcca acggcgtgcc gtgcagccgg ctgagcacca ggaacccgtg cggaccgccg  41880

tcccgcacct ccgacagcgg aaccggcacc cccaccccca gctccaccgc gtcgaccgcc  41940

gtcagcaccg ccacccgacc cggcagctcc gccgccgcgc cagccgtctt gggaaaccgg  42000

aacacccggt cacgcgcgat caacacgtcg tggaactggc cggagtgcac accggcaccc  42060

tcaagatcga catccgggtg ggcacgccga accacgtcaa caaggtggga caaggtcatg  42120

cccccacata gtgccgaccc accgaagcca ccgcgaccga tttatctcac ggtccgcacc  42180

cgtcccacta ctcagtgaaa tcccttacaa cgatcgggtg aatcgccgca cagcacccga  42240

accgaaccca cgcccgcgca cgaaccactg gagccgtccg gcgcacggcg gaatcgtgcg  42300

ccggacgggc ctgcgcgtgc cgccggttag agttcgcggg tggggaatgg cgagcggatc  42360

ggggtgttct acgacggcac ctggttcgcg tatttgagcg actacttcgc gtccgtgcac  42420

ccgcgggccg cccgggtctc gctggacggg ttccacgacg ccctgcgctg gtacgtgcac  42480

accgtcaccc accagccgtt ggacgagtgc gtggtcagtg aggcgcatta cgtccgcggc  42540

cggatcgaca cgccggcggt ggcgttcgac gccgtgttgg cggcggccgg ggtggtgcgg  42600

cacgacctgc cgctgcacgc gggcaaggag aagggggtgg acgtccacct cgcgctggag  42660

gcctgggagc gggccacctc cgtgccgttg cggtgggtcg tgctggtgac cggcgacgcg  42720

gacttcgcac ccctcgccac ccgcctcaag acacgcggcg tccgggtcgt ggtgccggtc  42780

gtggacggcg gggtcgtcgc gccggcgtgg atgccgcgca cggcggcgcc gctgcgcgcg  42840

gcggcgtcgg ccacgcccac gttcgacgac ctgttcacac ccgcggaacg cgacgactac  42900

ccgctgcggg cgccgttcgt gcggacctcc gggggcggcg cgtccgtcgc cggcgaaccc  42960

cgcggccggc gcaagggcac cgtcaccggg tggaaaaccg gccagccgca cgggttcatc  43020

accgacacgc gcggcgcgtc ctggttcgtc tcgcgcgacg acctcccgct ggggctggtg  43080

gccctgccgg tcggcacgtc cgtgtcgttc tccggcccgt ccactccccc ggccggacgc  43140

aagtacccgc gggcgtacgc ggtgcagacg gagtgatcag cccttcttga acagcagctt  43200

ccacggcatg accgcggact ccaactgcac cccgaagctc atcttggacg cgccctccgc  43260

ccgctcctcg aaccggatcg gcacctcggc gatgcgcatc ccgcgcttga ccacgcggtg  43320

gttcatctcg acctggaagg cgtacccgtt gctgcggatc gagccgacgt cgatcctgcg  43380

gagcgtcgcg gcgcgccagc acttgaagcc ggcggtggcg tccttgacgc gcagccgcag  43440

gatcgcgttg acgtagacgt tggcccacag ggaaagcgcc ttgcggtgcc acttccactc  43500

gccggacacc gacccgccgg gcacgtaacg cgaaccgatg acgaccgccg cgtccgacgt  43560

ccgcagcacc tcgatcatcg tcgggatggc gctcgccggg tgcgacaggt cggcgtccat  43620

ctggacgacc aggtcggcgc cgtcgtccag ggccttcagg atccccgcga cgtacgcgcg  43680

cccgaggccg tccttctccg tgcggtgcaa cacggaaagc ggaagcgggc cttcgagcgc  43740

caacttgtcc gcgaggtcgc cggtgccgtc gggggaattg tcgtcgacca ccaggacgtg  43800

caggcccggc acacccaggt cggcgagcag gtcgaccagg acgggcaggt tgtcccgctc  43860

gttgtaggtc ggcacgacga cggtggtcct gagcgagtcc ggttgtttcg acattccccc  43920

gagcttaccc gcgcgcggac gccgggaagt gcgcgaccgc ctcagtcgtg ccaggggagt  43980

tcgtcacgta gtccggtgtg gatcgcataa gcgttcttga tggcggcttt caccgagcct  44040

tccgcccaac gccggtgccg gcggtcacag gcgtcgttgg cgaaccacac ccggttcacc  44100

gggcggatcc ctttagtgag ggttaattgc ggccgcgaat t                      44141


<210>  2
<211>  2401
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  2

Met Thr Val Asp Pro Thr Ile Glu Leu Arg Leu Thr Leu Asn Gly Asp 
1               5                   10                  15      


Pro Asp Val Pro Ala Leu Thr Arg Ala Trp Ala Ala Leu Arg Ala Arg 
            20                  25                  30          


His Arg Ala Leu Ala Gly Pro Leu Gly Ala His Arg Asp Val Ala Ala 
        35                  40                  45              


Phe Glu Asp Ala Val Arg Ala Gly Pro Gly Cys His Leu Leu Arg Ala 
    50                  55                  60                  


Pro Gly Arg His Glu Phe Ala Leu Thr Ala Gly Cys Asp Ala Ala Ser 
65                  70                  75                  80  


Val Pro Ala Val Leu Ala Glu Leu Ser Ala Leu Tyr Ala Arg Glu Leu 
                85                  90                  95      


Gly His Pro Ser Glu Gly Leu Pro Ala Pro Ala Pro Ala Val Pro His 
            100                 105                 110         


Asp Arg Pro Pro His Asp Val Pro Pro Pro Gly Pro Glu Leu Pro Gly 
        115                 120                 125             


Leu Glu Leu Phe Gly Arg Gly Glu Pro Gly Pro Arg Val Val Thr Arg 
    130                 135                 140                 


Val Asp Leu Gly His Pro Thr Arg Arg His Val Ser Ala Leu Ala Arg 
145                 150                 155                 160 


Arg His Gly Val Thr Arg Glu Val Val Val Val Thr Ala Trp Ala Leu 
                165                 170                 175     


Leu Leu Gly Glu Leu Ala Glu Arg Asp Glu Phe Val Leu Gly Leu Val 
            180                 185                 190         


Thr Asp Pro Arg Asp Pro Ala Ala His Arg Pro Ala Val Gly Ala Leu 
        195                 200                 205             


Arg Glu Ala Arg Pro Leu Arg Val Asp Leu Thr Gly Arg Pro Ser Phe 
    210                 215                 220                 


Ala Asp Ala Val Arg Arg Thr Thr Ala Ala Val Ala Thr Ala Arg Ser 
225                 230                 235                 240 


Arg Pro Gly Asp Ala Pro Ala Asp Val Ala Val Gln Tyr Gly Glu Gln 
                245                 250                 255     


Pro Ala Ala Ala Leu Arg Leu Ala Gly Leu Asp Pro Ala Glu Val Pro 
            260                 265                 270         


Ala Ala Phe Trp Leu Ala Asp Asp Leu Pro Gly Pro His Arg Val Val 
        275                 280                 285             


Leu Arg Leu Leu Asp Thr Pro Asp Gly Leu Leu Ala Gly Val Ala His 
    290                 295                 300                 


His Pro Asp Ala Leu Asp Gly Pro Gly Ala Arg Arg Trp Val Ser Arg 
305                 310                 315                 320 


Leu Ala Ala Leu Leu Ala Gly Ala His Asp Glu Ser Pro Glu Pro Val 
                325                 330                 335     


Val Met Ser Glu Asp Glu His Arg Arg Val Val Leu Ala Pro Asn Ala 
            340                 345                 350         


Thr Ala Val Asp Leu Gly Ala Pro Ala Thr Val His Asp Leu Val Ala 
        355                 360                 365             


Glu Gln Ala Arg Arg Thr Pro Asp Arg Thr Ala Leu Val Phe Ala Gly 
    370                 375                 380                 


Ala Glu Val Gly Tyr Ala Glu Leu Asp Ala Arg Ala Asn Arg Leu Ala 
385                 390                 395                 400 


His Glu Leu Arg Glu Arg Gly Val Arg Arg Glu Thr Pro Val Ala Val 
                405                 410                 415     


Cys Leu Glu Arg Glu Thr Gly Leu Val Val Ala Leu Leu Ala Val Leu 
            420                 425                 430         


Lys Ala Gly Gly Ala Phe Val Pro Leu Asp Pro Gln Tyr Pro Arg Gln 
        435                 440                 445             


Arg Leu Ala His Met Leu Ala Asp Ser Gly Ala Ala Val Val Leu Thr 
    450                 455                 460                 


Gln Gly Arg Leu Arg Asp Arg Phe Ala Ala Asp Gly Pro Pro Val Leu 
465                 470                 475                 480 


Val Thr Asp Asp Asp Ala Thr Arg Phe Ala His His Pro Ser Ser Ala 
                485                 490                 495     


Pro Pro Ala Ser Ser Gly Pro Asp Asp Leu Ala Tyr Val Val Tyr Thr 
            500                 505                 510         


Ser Gly Ser Thr Gly Arg Pro Lys Gly Val Met Val Glu His Arg Gly 
        515                 520                 525             


Ile Ala Ser Tyr Leu Arg Gly Met Gln His Asp Phe Pro Leu Thr Pro 
    530                 535                 540                 


Glu Asp Arg Val Leu Gln Ala Thr Ser Leu Ser Phe Asp Val Ser Val 
545                 550                 555                 560 


Tyr Glu Ile Phe Trp Pro Leu Gln Val Gly Ala Ala Val Val Leu Pro 
                565                 570                 575     


Ala Pro Gly Gly His Thr Asp Pro Tyr His Leu Ser Glu Leu Ile Gln 
            580                 585                 590         


Arg His Gly Val Thr Cys Leu His Phe Val Pro Ser Leu Met Arg Leu 
        595                 600                 605             


Phe Val Glu Glu Ala Asp Pro Gly Ala Gly Ala Gly Leu Arg Arg Val 
    610                 615                 620                 


Phe Val Ser Gly Glu Ala Leu Asp Pro Ser Leu Val Ala Leu Val His 
625                 630                 635                 640 


Glu Arg Thr Ser Ala Glu Leu Val Asn Leu Tyr Gly Ala Thr Glu Val 
                645                 650                 655     


Ser Val Asp Ser Thr Tyr Trp Thr Ala Asp Arg Ala Lys Pro Asp Arg 
            660                 665                 670         


Pro Val Leu Val Gly Arg Pro Met Ala Asn Ala Thr Ala Tyr Val Leu 
        675                 680                 685             


Asp Gln Arg Leu Arg Pro Lys Pro Ala Gly Val Val Gly Glu Val Phe 
    690                 695                 700                 


Leu Gly Gly Ala Ser Val Thr Arg Gly Tyr His Ala Arg Pro Ala Leu 
705                 710                 715                 720 


Thr Ala Glu Arg Phe Val Pro Asp Pro Phe Gly Pro Pro Gly Ser Arg 
                725                 730                 735     


Leu Tyr Arg Thr Gly Asp Leu Gly Arg Val Thr Pro Asp Gly Glu Leu 
            740                 745                 750         


Glu Phe Leu Gly Arg Arg Asp His Gln Phe Lys Leu Arg Gly Trp Arg 
        755                 760                 765             


Val Glu Ala Gly Glu Ile Glu Ala Ala Ile Thr Ala His Pro Gly Val 
    770                 775                 780                 


Asn Gly Ala Val Val Val Thr Glu Gly Ala His Glu His Ala Thr Leu 
785                 790                 795                 800 


Leu Ala Tyr Val Gly Ala Asp Ala Gly Leu Asp Gln Ala Ala Leu Arg 
                805                 810                 815     


Glu Phe Leu Ala Arg Arg Leu Pro Arg Pro Leu Val Pro Ala Arg Phe 
            820                 825                 830         


Ile Arg Leu Asp Arg Leu Pro Ile Ser Pro Asn Gly Lys Val Asp Arg 
        835                 840                 845             


Ala Ala Leu Pro Lys Pro Asp Gln Ala Pro Ala Glu Pro Ala Pro Thr 
    850                 855                 860                 


Thr Ala Ala Pro Pro Thr His Ala Ala Asp Gly Arg Pro Ala Leu Glu 
865                 870                 875                 880 


His Ala Ala Asp Gly Arg Pro Ala Leu Glu Arg Gly Ser Asp Gly Arg 
                885                 890                 895     


Pro Val Leu Glu Val Val Leu Ala Val Ala Ala Glu Val Leu Gly Ala 
            900                 905                 910         


Pro Ile Gly Pro Glu Asp Ser Phe Phe Gly Ser Gly Gly Asn Ser Ile 
        915                 920                 925             


Gln Ala Thr Arg Leu Ala Ala Arg Leu Arg Ala Ala Leu Arg Thr Asp 
    930                 935                 940                 


Val Pro Val Arg Leu Ala Phe Glu Ala Pro Thr Pro Ala Ala Met Ala 
945                 950                 955                 960 


Ala Leu Leu Ser Pro Pro Ser Pro Glu Pro Val Ala Glu Val Ser Arg 
                965                 970                 975     


Ala Glu Gln Arg Ile Trp Leu Leu Ser Arg Leu Gly Gly His Pro Ala 
            980                 985                 990         


Glu Tyr Ala Ile Pro Val Ala Leu  Arg Leu Ala Gly Pro  Leu Asp Val 
        995                 1000                 1005             


Ala Lys  Leu Lys Asn Ala Val  Asp Ala Val Val Arg  Arg His Glu 
    1010                 1015                 1020             


Gly Leu  Arg His Val Phe Pro  Glu Val Asp Gly Ser  Pro Thr Arg 
    1025                 1030                 1035             


Ala Val  Leu Asp Pro Gly Ser  Ile Thr Val Ala Glu  Glu Ala Asn 
    1040                 1045                 1050             


Arg Ser  Val Arg Glu Val Leu  Ala Glu Gly Val Ala  Ala Leu Asp 
    1055                 1060                 1065             


Pro Ala  Thr Gly Pro Leu Ala  Arg Phe Thr Leu Val  Asn Gln Gly 
    1070                 1075                 1080             


Pro Gln  Asp His Val Leu Ala  Ile Val Leu His His  Leu Ile Ala 
    1085                 1090                 1095             


Asp Gly  Trp Ser Val Asp Val  Leu Leu Arg Asp Ile  Ala Ala His 
    1100                 1105                 1110             


Tyr Thr  Gly Ala Pro Thr Ala  Thr Pro Gly Arg Tyr  Ala Asp Tyr 
    1115                 1120                 1125             


Leu Ala  Leu Glu Arg Ala Glu  Glu Gln Asp Gly Ala  Leu Gly Arg 
    1130                 1135                 1140             


Ala Leu  Glu His Phe Val Thr  Ala Leu Asp Gly Val  Pro Asp Glu 
    1145                 1150                 1155             


Val Ser  Phe Pro Pro Asp His  Pro Arg Pro Ala Gln  Arg Thr Gly 
    1160                 1165                 1170             


Arg Gly  Asp Val Val Arg His  Arg Ile Asp Ala Ala  Pro Val Thr 
    1175                 1180                 1185             


Ala Leu  Ala Glu Arg Leu Arg  Thr Thr Pro Phe Ala  Val Leu Leu 
    1190                 1195                 1200             


Ala Ala  Val Gly Val Leu Leu  His Arg Val Gly Gly  His Arg Asp 
    1205                 1210                 1215             


Val Val  Val Gly Thr Ala Val  Ala Arg Arg Pro Asp  Ala Gly Leu 
    1220                 1225                 1230             


Asp His  Leu Val Gly Leu Cys  Leu Asn Thr Leu Ala  Leu Arg Trp 
    1235                 1240                 1245             


Pro Val  Gln Pro His Asp Thr  Leu Gly Glu Val Val  Arg Ala Val 
    1250                 1255                 1260             


Thr Asp  Arg Leu Ala Asp Gly  Leu Gln His Asp Ala  Ala Ser Phe 
    1265                 1270                 1275             


Asp Arg  Val Val Asp Lys Leu  Ala Pro Ala Arg Asp  Ser Gly Arg 
    1280                 1285                 1290             


Thr Pro  Val Phe Gln Val Met  Ala Leu Tyr Glu Glu  Pro Tyr Glu 
    1295                 1300                 1305             


Thr Ala  Leu Ala Leu Pro Asp  Val Thr Thr Thr Asp  Val Thr Val 
    1310                 1315                 1320             


His Cys  Gly Ser Ala Gln Ala  Asp Ala Ala Phe Gly  Phe Val Pro 
    1325                 1330                 1335             


Arg Glu  Gly Gly Ile Asp Leu  Thr Leu Gln Phe Ser  Thr Asp Val 
    1340                 1345                 1350             


Phe Thr  Arg Ala Thr Ala Ser  Arg Trp Ala Arg Arg  Leu Ala Thr 
    1355                 1360                 1365             


Leu Leu  Ala Gly Ala Arg Ala  Asp Thr Arg Val Ala  Asp Leu Pro 
    1370                 1375                 1380             


Leu Leu  Pro Glu Asp Glu Ser  Gln Asp Leu Glu Arg  Trp Ser Gly 
    1385                 1390                 1395             


Thr Thr  Gly Glu Ala Pro Thr  Thr Thr Leu His Ala  Leu Ala His 
    1400                 1405                 1410             


Glu Ile  Ala Gln Arg His Pro  Asp Arg Pro Ala Ile  His Phe Gly 
    1415                 1420                 1425             


Gln Asn  Ser Leu Thr Tyr Gly  Glu Phe Asp Ala Arg  Ser Ala Gln 
    1430                 1435                 1440             


Leu Ala  His Glu Leu Arg Ala  Arg Gly Val Arg Ala  Glu Thr Pro 
    1445                 1450                 1455             


Val Val  Val Cys Leu Glu Arg  Ser Pro Glu Ala Leu  Ile Ala Val 
    1460                 1465                 1470             


Tyr Gly  Val Leu Lys Ala Gly  Gly Ala Tyr Val Pro  Val Glu Thr 
    1475                 1480                 1485             


Ser Asn  Pro Asp Leu Arg Ile  Ala Glu Leu Ile Ala  Asp Ser Gly 
    1490                 1495                 1500             


Ala Ala  Leu Val Leu Thr Gln  Arg Arg Leu Ala Asp  Arg Leu Ala 
    1505                 1510                 1515             


Ala Leu  Gly Ala Glu Val Val  Val Val Asp Glu Pro  Leu Pro Arg 
    1520                 1525                 1530             


His Pro  Thr Thr Asp Pro Glu  Pro Leu Thr Gly Pro  Asp His Leu 
    1535                 1540                 1545             


Ala Tyr  Val Ile Tyr Thr Ser  Gly Ser Thr Gly Arg  Pro Lys Gly 
    1550                 1555                 1560             


Val Met  Val Gln His Gly Ser  Val Leu Asn Phe Leu  Asp Ala Leu 
    1565                 1570                 1575             


Asp Arg  Arg Phe Asp Leu Thr  Pro Asp Asp Arg Leu  Leu His Lys 
    1580                 1585                 1590             


Ser Pro  Leu Ala Phe Asp Val  Ser Val Arg Glu Val  Phe Trp Ala 
    1595                 1600                 1605             


Leu Thr  Arg Gly Ala Ser Val  Val Val Ala Glu Pro  Gly Arg His 
    1610                 1615                 1620             


Ala Asp  Pro Gly His Leu Val  Asp Leu Val Glu Arg  Glu Arg Val 
    1625                 1630                 1635             


Thr Val  Ala His Phe Val Pro  Ser Ser Leu Ala Val  Phe Leu Glu 
    1640                 1645                 1650             


Gly Leu  Pro Gly Pro Gly Arg  Cys Pro Thr Leu Arg  His Val Leu 
    1655                 1660                 1665             


Thr Ser  Gly Glu Thr Leu Pro  Val Thr Thr Ala Arg  Ala Ala Arg 
    1670                 1675                 1680             


Asp Leu  Leu Gly Ala Arg Leu  Arg Asn Met Tyr Gly  Pro Thr Glu 
    1685                 1690                 1695             


Thr Thr  Val Glu Met Thr Asp  His Asp Val Val Asp  Asp Thr Val 
    1700                 1705                 1710             


Asp Arg  Leu Pro Ile Gly His  Pro Phe Glu Gly Ala  Val Val Arg 
    1715                 1720                 1725             


Val Leu  Asp Ala Asp Leu Arg  Pro Val Pro Pro Gly  Ser Thr Gly 
    1730                 1735                 1740             


Glu Leu  Cys Val Gly Gly Leu  Pro Val Ala Arg Gly  Tyr Leu Gly 
    1745                 1750                 1755             


Arg Pro  Ala Leu Thr Ala Glu  Arg Phe Val Pro Asp  Pro Leu Gly 
    1760                 1765                 1770             


Pro Ala  Gly Ala Arg Leu Tyr  Arg Thr Gly Asp Leu  Ala Arg Leu 
    1775                 1780                 1785             


Leu Pro  Asp Gly Gln Leu Asp  Phe Leu Gly Arg Asn  Asp Phe Gln 
    1790                 1795                 1800             


Val Lys  Val Arg Gly His Arg  Ile Glu Pro Gly Glu  Val Glu Ala 
    1805                 1810                 1815             


Val Leu  Gly Ala Leu Pro Gly  Val His Gly Ala Leu  Val Thr Ala 
    1820                 1825                 1830             


His Asp  Asp Arg Leu Ile Gly  Tyr Ala Val Thr Asp  Arg Asp Gly 
    1835                 1840                 1845             


Glu Glu  Leu Arg Thr Ala Leu  Ala Glu Arg Leu Pro  Glu His Leu 
    1850                 1855                 1860             


Val Pro  Ser Val Val Leu Thr  Leu Asp Arg Phe Pro  Leu Thr Gly 
    1865                 1870                 1875             


Asn Gly  Lys Leu Asp Arg Ala  Ala Leu Pro Thr Pro  Thr Gly Arg 
    1880                 1885                 1890             


His Thr  Gly Asp Ser Arg Pro  Leu Thr Ala Thr Glu  Ala Ala Leu 
    1895                 1900                 1905             


Ala Ala  Ile Trp Arg Asp Leu  Leu Asp Val Pro Glu  Val Arg Ala 
    1910                 1915                 1920             


Asp Asp  His Phe Phe Ala Leu  Gly Gly His Ser Leu  Leu Ala Ala 
    1925                 1930                 1935             


Arg Val  Ala Ala Arg Ala Gly  Ala Ala Leu Gly Val  Ala Leu Pro 
    1940                 1945                 1950             


Leu Pro  Thr Val Leu Arg Phe  Pro Arg Leu Ala Asp  Leu Ala Thr 
    1955                 1960                 1965             


Ala Val  Asp Gly Thr Arg Ala  Asp Arg Glu Pro Val  Arg Pro Arg 
    1970                 1975                 1980             


Pro Asp  Arg Arg Arg Arg Ala  Pro Leu Ser Ser Ala  Gln Arg Arg 
    1985                 1990                 1995             


Leu Trp  Ile Glu Glu Asn Leu  Arg Pro Gly Thr Ala  Thr Tyr Thr 
    2000                 2005                 2010             


Val Ala  Glu Ala Phe Arg Leu  Arg Gly Glu Leu Asp  Glu Glu Ala 
    2015                 2020                 2025             


Phe Ala  Ala Ala Val Asp Asp  Val Leu Arg Arg His  Asp Ala Leu 
    2030                 2035                 2040             


Arg Ala  His Val Glu Ser Val  Glu Asp Gly Glu Pro  Glu Leu Val 
    2045                 2050                 2055             


Val Ala  Pro Glu Pro Arg Thr  Ala Leu Arg Val Gly  Asp Leu Pro 
    2060                 2065                 2070             


Ala Asp  Arg Val Arg Asp Ala  Leu Ala Ala Glu Ser  Ala Arg Val 
    2075                 2080                 2085             


Phe Asp  Pro Ala Gly Pro Leu  Val Ala Thr Ser Leu  His Arg Leu 
    2090                 2095                 2100             


Ala Pro  Asp Glu Trp Leu Phe  Gln Phe Thr Ala His  His Leu Val 
    2105                 2110                 2115             


Val Asp  Gly Trp Ser Leu Asp  Val Leu Trp Arg Asp  Leu Ala Ala 
    2120                 2125                 2130             


Cys Tyr  His Asp Arg Arg Ala  Gly Arg Ala Pro Arg  Pro Arg Asp 
    2135                 2140                 2145             


Gly Leu  Thr Phe Thr Asp Tyr  Thr Trp Trp Glu Arg  Asp Val Arg 
    2150                 2155                 2160             


Ser Arg  Asp Leu Glu Pro His  Leu Ala Phe Trp Arg  Gly Glu Leu 
    2165                 2170                 2175             


Ala Gly  Leu Arg Pro Gln Pro  Pro Ala Asp Ala His  Gly Pro Gly 
    2180                 2185                 2190             


Ala Val  Leu Asp Phe Ala Leu  Gly Ala Ala Leu Ser  Asp Glu Leu 
    2195                 2200                 2205             


Arg Ala  Thr Ala Ala Gly Leu  Gly Val Ser Pro Phe  Val Leu Gly 
    2210                 2215                 2220             


Leu Thr  Ala Phe Ala Leu Ala  Leu Gly Glu Asp Ser  Pro Gly Ala 
    2225                 2230                 2235             


Ile Gly  Val Glu Val Ala Asn  Arg Ala Ser Ala Glu  Thr Ala Asp 
    2240                 2245                 2250             


Leu Val  Gly Leu Phe Val Asn  His Val Pro Val Arg  Val Ala Pro 
    2255                 2260                 2265             


Arg Gly  Thr Gly Arg Ala Ala  Val Ala Ala Val Asp  Glu Ala Arg 
    2270                 2275                 2280             


Arg Arg  Val Leu Pro His Glu  His Val Pro Phe Asp  Leu Val Val 
    2285                 2290                 2295             


Asp Leu  Leu Gly Pro Gly Arg  Ala Pro Thr Ser Val  Ala Phe Ser 
    2300                 2305                 2310             


His Leu  Asp Val Arg Gly His  Ser Pro Arg Leu Asp  Gly Val Thr 
    2315                 2320                 2325             


Ala Thr  Arg Leu Thr Pro Pro  His Asn Gly Thr Ala  Lys Phe Asp 
    2330                 2335                 2340             


Leu Leu  Leu Glu Val Leu Asp  Thr Glu His Gly Leu  Thr Gly Ala 
    2345                 2350                 2355             


Phe Glu  Tyr Arg Pro Glu Arg  Phe Thr Ala Ala Arg  Val Ala Gln 
    2360                 2365                 2370             


Val Arg  Asn His Trp Glu Ala  Ala Leu Leu Thr Leu  Leu Ala Asp 
    2375                 2380                 2385             


Pro Asp  Leu Pro Val Asp Ala  Arg Arg Pro Asp Phe  Ala 
    2390                 2395                 2400     


<210>  3
<211>  362
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  3

Met Leu Ser Thr Val Asp Pro Ala Ala Glu Leu Ser Thr Thr Ala Ala 
1               5                   10                  15      


Glu Val Leu Glu His Val Asp Ala Ala Val Ala Ala Tyr Pro Glu Val 
            20                  25                  30          


Pro Ile Ala Arg Val Arg Val Glu Val Ala Gly Ile Pro Arg Thr Leu 
        35                  40                  45              


Leu Leu Lys Leu Glu Gly Arg Ser Pro Trp Arg Ser Ile Lys Gly Arg 
    50                  55                  60                  


Thr Ala Leu Gly Leu Val Arg Ser Ile Ala Pro Arg Met Ala Ser Arg 
65                  70                  75                  80  


Asp Val Thr Val Val Glu Ser Thr Ser Gly Asn Leu Gly Val Ala Leu 
                85                  90                  95      


Ser Ala Ile Cys Arg Asp Leu Gly Leu Pro Phe Val Ala Val Val Asp 
            100                 105                 110         


Leu Lys Gln Ser Pro Val Ile Gln Ala Ala Ile Glu Ala Asn Gly Ala 
        115                 120                 125             


Arg Leu Glu Val Val Arg Thr Pro Ala Ala Ala Thr Thr His Leu Leu 
    130                 135                 140                 


Asp Arg Leu Asp Arg Val Arg Lys Leu Val Ala Glu Ile Pro Gly Ala 
145                 150                 155                 160 


Val Trp Pro Asn Gln Tyr Glu Asn Asp Ala Asn Arg His Val His Glu 
                165                 170                 175     


Thr Trp Thr Ala Pro Glu Ile Asp Arg Gln Val Gly Gly Glu Ala Gln 
            180                 185                 190         


Ala Val Phe Val Ala Val Ser Thr Gly Gly Thr Leu Ala Gly Leu Ala 
        195                 200                 205             


Ala His Phe Arg Arg Ala Arg Pro Ala Thr Arg Leu Val Ala Val Asp 
    210                 215                 220                 


Val Glu Gly Ser Thr Val Phe Gly Gly Val Pro Gly Gly Arg Val Leu 
225                 230                 235                 240 


Thr Gly Ile Gly Ala Ser Arg Arg Ser Thr Phe Leu Thr Arg Ala Glu 
                245                 250                 255     


Cys Asp Asp Leu Val Tyr Val Arg Glu Ala Ala Ala Ile Ala Ala Cys 
            260                 265                 270         


His Val Leu Arg Ala Asp Thr Gly Ile Ala Val Gly Gly Ser Ser Gly 
        275                 280                 285             


Ala Val Val Ala Gly Ala Leu Asp His Leu Ala Ala His Pro Gly Leu 
    290                 295                 300                 


Thr Thr Ala Val Cys Val Cys Ala Asp Leu Gly Glu Asn Tyr Ala Arg 
305                 310                 315                 320 


Thr Val Tyr Asp Pro Asp Trp Leu Ala Pro Leu Arg Leu Thr Asp Asp 
                325                 330                 335     


Pro Gly Leu Leu Arg Ser Arg Leu Arg Gly Ala Arg Phe His His Ala 
            340                 345                 350         


Glu Pro Asp Thr Gly Gln Glu Ser Thr Pro 
        355                 360         


<210>  4
<211>  338
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  4

Met Thr Ala Ile Arg Glu Ile Arg Leu Ser Glu Pro Glu Ser Ala Gln 
1               5                   10                  15      


Ala Ala Leu Leu Ala Leu Glu Cys Ala Gln Arg Tyr Ala Glu Pro Asp 
            20                  25                  30          


Ser Ala Asp Phe Leu Ala Asp Ala Ala Val Leu Ala His Asp Leu Pro 
        35                  40                  45              


Arg Ala Val Arg Arg Glu Val Glu Arg Ala Arg Leu Asp Asp Arg Leu 
    50                  55                  60                  


His Ala Leu Val Val Arg Gly Asn Asp Val Asp Gln Asp Ala Leu Gly 
65                  70                  75                  80  


Pro Thr Pro Pro His Trp Arg Gln Ala Arg Thr Ala Ala Ser Arg Arg 
                85                  90                  95      


Tyr Gly Phe Leu Leu Val Leu Tyr Ala Ser Leu Leu Gly Asp Val Val 
            100                 105                 110         


Gly Trp Ala Thr Gln Gln Asp Gly Arg Val Val Thr Asp Val Leu Pro 
        115                 120                 125             


Ile Glu Gly Gln Glu Asp Ser Leu Val Ser Ser Ser Ser Ser Val Glu 
    130                 135                 140                 


Leu Gly Trp His Thr Glu Asp Ala Phe Ser Pro Tyr Arg Ala Asp Tyr 
145                 150                 155                 160 


Val Gly Leu Phe Ser Leu Arg Asn Pro Asp Ser Val Ala Thr Thr Val 
                165                 170                 175     


Ala Gly Leu Asp Pro Asp Leu Val Gly Pro Ala Val Val Asp Val Leu 
            180                 185                 190         


Phe Gly Glu Arg Phe His Ile Arg Pro Asp Asn Ser His Leu Pro Thr 
        195                 200                 205             


His Asn Ser Gly Gly Arg Leu Ser Asp Tyr Phe Ala Gly Ile Val Glu 
    210                 215                 220                 


Ala Val Glu Asn Pro Arg Ala Val Ser Ile Leu Arg Gly His Arg Asp 
225                 230                 235                 240 


Ala Pro Gln Leu Cys Val Asp Ser Asp Phe Thr Thr Ala Val Asp Gly 
                245                 250                 255     


Asp Ala Glu Ala Ala Gly Ala Leu Asp Thr Leu Ile Lys His Leu Gly 
            260                 265                 270         


Gly Ala Leu Tyr Glu Val Val Leu Gly Pro Gly Asp Val Ala Phe Leu 
        275                 280                 285             


Asp Asn Arg Asn Val Val His Gly Arg Arg Pro Phe Arg Ala Arg Phe 
    290                 295                 300                 


Asp Gly Thr Asp Arg Trp Leu Lys Arg Ile Asn Val Thr Ala Asp Leu 
305                 310                 315                 320 


Arg Lys Ser Arg Ala Ala Arg Arg Asp Ala Gln Ala Arg Val Leu Gly 
                325                 330                 335     


Glu Ala 
        


<210>  5
<211>  373
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  5

Met Met Val Arg Asp Leu Pro Ala Ala Ala Leu Glu Asp Trp Leu Arg 
1               5                   10                  15      


Glu Arg Tyr Phe Thr Ala Arg Val Asp Val Ser Ser Ser Gly Val Ala 
            20                  25                  30          


Asp His Arg Leu Ala Asp Leu Arg Arg Leu Gly Gly Ile Thr Val Glu 
        35                  40                  45              


Glu Leu Asp Ala Val Val Phe Arg Asp Gly Pro Ser Leu Gly Ala Glu 
    50                  55                  60                  


Arg Leu Arg Ala Ala Leu Ala Asp Arg Leu Arg Pro Gly Pro Asp His 
65                  70                  75                  80  


Val Val Met Thr Ala His Gly Ser Ser Glu Ala Leu Phe Leu Ala Met 
                85                  90                  95      


Thr Ala Leu Val Arg Pro Gly Asp Glu Val Val Val Pro Asp Pro Ala 
            100                 105                 110         


Tyr His Ser Leu Ser Ala Leu Ala Arg Ala Cys Gly Ala Val Leu Arg 
        115                 120                 125             


Pro Trp Pro Val Leu Gly Ala Ala Pro Asp Pro Ala Asp Leu Arg Ala 
    130                 135                 140                 


Leu Leu Thr Pro Arg Thr Arg Leu Val Val Val Asn Phe Pro His Asn 
145                 150                 155                 160 


Pro Thr Gly Val Thr Val Asp Ala Ala Val Gln Ala Glu Leu Leu Asp 
                165                 170                 175     


Val Val Gly Arg Ser Gly Ala Tyr Leu Leu Trp Asp Asn Ala Phe Arg 
            180                 185                 190         


Asp Leu Val Tyr Asp Ala Pro Pro Leu Pro Glu Pro Thr Ala Leu Gly 
        195                 200                 205             


Gly Arg Val Leu Ser Thr Gly Thr Leu Ser Lys Ala His Gly Leu Pro 
    210                 215                 220                 


Gly Leu Arg Val Gly Trp Cys Val Leu Pro Ala Asp Leu Ala Pro Glu 
225                 230                 235                 240 


Leu Val Arg Val Arg Asp Tyr Leu Thr Leu Ser Leu Ser Pro Leu Thr 
                245                 250                 255     


Glu Leu Leu Ala Ala Val Ala Val Glu His Ala Asp Glu Leu Ile Ala 
            260                 265                 270         


Pro Arg Leu Ala Glu Ala Thr Ala Asn Arg Arg Arg Leu Leu Asp Trp 
        275                 280                 285             


Ala Ala Ala His Gly Val Asp Cys Pro Ala Pro Gly Gly Gly Val Thr 
    290                 295                 300                 


Ala Phe Pro Arg Phe Pro Gly Val Ala Asp Val Thr Pro Leu Cys Asp 
305                 310                 315                 320 


Arg Leu Met Ser Glu His Gly Val Leu Thr Val Pro Gly Gly Cys Phe 
                325                 330                 335     


Gly Phe Pro Asp Arg Met Arg Ile Gly Phe Gly Cys Asp Pro Ala Val 
            340                 345                 350         


Phe Ala Ala Gly Leu Thr Ala Leu Gly Ala Val Leu Ala Glu Lys Arg 
        355                 360                 365             


Leu Pro Ala Lys Leu 
    370             


<210>  6
<211>  415
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  6

Met Ala Ala Ile Glu Asn Ala Pro Arg Arg Leu Arg Asp Asn Arg Asp 
1               5                   10                  15      


Phe Arg Phe Trp Trp Gly Gly Thr Val Leu Ser Ala Ile Gly Asp Glu 
            20                  25                  30          


Val Thr Leu Ile Ala Phe Pro Leu Leu Val Leu Phe Leu Thr Gly Ser 
        35                  40                  45              


Pro Thr His Ala Gly Leu Val Gly Gly Val Ala Ala Val Pro Pro Leu 
    50                  55                  60                  


Leu Leu Ser Val Pro Ile Gly Val Leu Ala Asp Arg Thr Ser Arg Arg 
65                  70                  75                  80  


Ala Leu Met Leu Gly Gly Ser Val Val Ser Ala Ile Ser Ile Thr Ser 
                85                  90                  95      


Ile Pro Val Val His Leu Leu Gly Glu Leu Thr Leu Pro His Leu Tyr 
            100                 105                 110         


Val Val Ala Phe Val Asn Ser Val Ala Ala Thr Val Tyr Arg Ile Ala 
        115                 120                 125             


Asp Thr Ala Ala Leu Pro Arg Ile Ala Gly Glu Glu Lys Leu Gly Glu 
    130                 135                 140                 


Ala Ala Ser Gln Ser Glu Thr Ile Trp Gly Ile Ser Ala Ile Val Ala 
145                 150                 155                 160 


Pro Pro Leu Ala Gly Leu Leu Phe Glu Thr Ala Gly Pro Thr Ser Pro 
                165                 170                 175     


Phe Trp Ile Asp Ala Val Ser Phe Val Ala Ile Met Val Cys Val Leu 
            180                 185                 190         


Ala Ile Arg Ala Arg Leu Gly Ala Asp Lys Pro Tyr Pro Glu Val Ser 
        195                 200                 205             


Trp Arg Gln Asp Leu Thr Thr Gly Ala Arg Val Thr Leu Ser Arg Pro 
    210                 215                 220                 


Leu Val Arg Ala Leu Thr Ile Leu Thr Val Ala Gly Asp Phe Leu Phe 
225                 230                 235                 240 


Ala Gly Ile Gly Leu Leu Leu Ile Val Met Val Arg Glu Asn Gly Ala 
                245                 250                 255     


Ser Gly Leu Glu Thr Gly Thr Val Phe Thr Ala Ala Ala Val Gly Gly 
            260                 265                 270         


Ile Leu Gly Ser Met Leu Ala Gly Arg Val Glu Asp Arg Ile Gly Met 
        275                 280                 285             


Val Pro Ala Val Leu Thr Lys His Trp Leu Thr Ala Ala Leu Phe Pro 
    290                 295                 300                 


Leu Leu Leu Val Asp Leu Pro Gly Trp Ala Thr Gly Leu Val Trp Gly 
305                 310                 315                 320 


Leu Ile Ser Phe Gln Ile Ser Ile Leu Asn Val Ile Gln Met Lys Tyr 
                325                 330                 335     


Leu Met Ser Val Ile Pro Asn Ser Lys Leu Gly Arg Val Glu Gly Phe 
            340                 345                 350         


Leu Thr Phe Ile Glu Gln Gly Ser Leu Pro Leu Gly Tyr Ala Leu Thr 
        355                 360                 365             


Gly Val Leu Leu Gly Leu Leu Gly Thr Thr Ser Thr Leu Leu Ala Tyr 
    370                 375                 380                 


Glu Ala Val Leu Leu Val Leu Ala Val Phe Ala Thr Val Ser Arg Gly 
385                 390                 395                 400 


Leu Arg Thr Pro Ala His Pro Asp Glu Pro Ala Arg Ser Ser Gly 
                405                 410                 415 


<210>  7
<211>  1056
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  7

Met Thr Gln Val Asp Phe Thr Arg Trp Asp Leu Arg Thr Asp Ala Glu 
1               5                   10                  15      


Lys His Ala Thr Pro Thr Val Leu Ser Gly Pro Pro Pro Ala Trp Ser 
            20                  25                  30          


Pro Asp Thr Thr Leu Ala Arg Leu Val Leu Asp Gln Ala Asp Arg Thr 
        35                  40                  45              


Pro Asp Ala Asp Ala Val Arg Ile Gly Pro Asp Ala Leu Thr Tyr Arg 
    50                  55                  60                  


Glu Leu Ala Ala Gly Ala Arg Arg Val Ala Ala Trp Val Ala Arg Gln 
65                  70                  75                  80  


Pro His Thr Gly Pro Pro Arg Val Gly Val Leu Gly Glu Arg Ser Leu 
                85                  90                  95      


Ala Thr Tyr Pro Val Leu Leu Gly Val Leu Leu Ala Gly Gly Ala Tyr 
            100                 105                 110         


Val Pro Leu Asp Pro Ala Ala Pro Pro Ala Arg Leu Arg Ala Val Leu 
        115                 120                 125             


Ser Arg Ala Asp Ala His Ala Val Val Thr Thr Ala Glu Ser Trp Ala 
    130                 135                 140                 


Leu Leu Glu Gln Pro Gly Leu Pro Ala Leu Leu Thr Asp Gln Pro Leu 
145                 150                 155                 160 


Pro Phe Gln Arg Ser Lys Val Asp Ser Gly Arg Val Ala Val Leu Ala 
                165                 170                 175     


Gly Leu Pro Asp Ala Gly Glu Pro Val Gly Pro Thr Pro Asp Asp Val 
            180                 185                 190         


Ala Tyr Val Ile Phe Thr Ser Gly Ser Thr Gly Thr Pro Lys Gly Val 
        195                 200                 205             


Val Val Gln His Arg Ala Ala Val Asn Leu Thr Cys Trp Ala Arg Asp 
    210                 215                 220                 


Leu Val Pro Met Gly Pro Gly Ser Arg Val Thr Gln Asn Ala Ser Leu 
225                 230                 235                 240 


His Phe Asp Ala Ser Val Gln Gln Ile Phe Pro Ala Leu Ala Ser Gly 
                245                 250                 255     


Ala Thr Leu Phe Pro Val Pro Glu Arg Val Arg Leu Ser Gly Pro Glu 
            260                 265                 270         


Leu Ala Ala Trp Leu Ala Arg His Arg Ile Thr His Trp Asp Ser Val 
        275                 280                 285             


Pro Ser Leu Trp Thr Pro Val Val Glu His Leu Ala Asp Arg Ile Ala 
    290                 295                 300                 


Ala Gly Gln Arg Val Leu Pro Asp Leu Arg Ala Val Leu Leu Ala Gly 
305                 310                 315                 320 


Glu Pro Leu Pro Ala Arg Gln Val Asp Arg Trp Arg Ser Trp Glu Gln 
                325                 330                 335     


Gly His Arg Leu Phe Asn Val Tyr Gly Pro Thr Glu Val Thr Val Asn 
            340                 345                 350         


Ala Thr Ala Phe Glu Val Thr Gly Pro Val Gly Ala Val Val Pro Ile 
        355                 360                 365             


Gly Arg Pro Leu Pro Gly Ile Thr Ala Ser Val Leu Asp Ala His Gly 
    370                 375                 380                 


Asn Pro Cys Pro Val Asp Ala Asp Gly Glu Leu Phe Leu Gly Gly Val 
385                 390                 395                 400 


Gly Leu Ala Arg Gly Tyr Leu Asp Asp Pro Glu Gly Thr Ala Arg Ser 
                405                 410                 415     


Phe Val Glu Arg Gly Gly Glu Arg Phe Tyr Arg Thr Gly Asp Val Val 
            420                 425                 430         


Arg Val Gly Ala Asp Gly Leu Leu Val Phe Val Gly Arg Arg Asp Asp 
        435                 440                 445             


Gln Val Lys Leu Asn Gly Val Arg Val Glu Pro Ala Glu Ile Glu His 
    450                 455                 460                 


Ala Leu Leu Ala His Pro Gly Val Thr Glu Ala Val Ala Val Val Leu 
465                 470                 475                 480 


Arg Glu Glu Gly Arg Ala Glu Leu Val Ala Cys Val Ala Ser Ala Val 
                485                 490                 495     


Glu Leu Ser Thr Glu Asp Ile Arg Ala Gly Leu Ala Glu Glu Leu Pro 
            500                 505                 510         


Ala Ala Leu Val Pro Ser Arg Val Val Val Val Glu Ser Leu Pro His 
        515                 520                 525             


Asn Ala Asn Gly Lys Leu Asp Arg Ala Ala Cys Ala Glu Leu Ala Arg 
    530                 535                 540                 


Asp Leu Ser Gly Pro Ser Gly Gly Ala Gly Pro Leu Gly Ala Thr Ala 
545                 550                 555                 560 


Ala Thr Leu Leu Gly Ile Trp Arg Ser Val Leu Gly Arg Asp Asp Ile 
                565                 570                 575     


Gly Pro Asp Asp Glu Phe Phe Gln Val Gly Gly Asn Ser Ile Thr Ser 
            580                 585                 590         


Ile Arg Leu Arg Arg Glu Cys Val Glu Ala Gly Leu Pro Ile Arg Ala 
        595                 600                 605             


Val Asp Val Phe Leu His Pro Thr Val Arg Arg Leu Ala Arg Tyr Val 
    610                 615                 620                 


Asp Asp Asn Arg Thr Thr Leu Ala Ala Arg Ala Arg Pro Ala Pro Glu 
625                 630                 635                 640 


Glu Ser Pro Thr Asp Gly Glu Phe Pro Leu Leu Pro Ala Gln Arg Pro 
                645                 650                 655     


Leu Ala Leu Thr Ala Leu Leu Ser Asp Gly Gly Ala Gln Arg Gly Leu 
            660                 665                 670         


Val Gln Glu Thr Val Thr Tyr Arg Val Pro Leu Asp Val Asp Ala Val 
        675                 680                 685             


Arg Gly Ala Leu Glu Val Leu Leu Glu Arg His Glu Val Leu Arg Thr 
    690                 695                 700                 


Ala Val Thr Pro Gly Leu Ala Gln Arg Val Leu Pro Lys Val Pro Val 
705                 710                 715                 720 


Pro Leu Glu Val Val Asp Leu Thr Gly Val Ala Asp Gln Trp Gly Ala 
                725                 730                 735     


Val Leu Glu Ala Ala Asp Arg Asp Tyr Ala Thr Pro Phe Asp Leu Ala 
            740                 745                 750         


Glu Pro Pro Leu Val Arg Val Arg Ala Phe Asp Arg Gly Glu Val Phe 
        755                 760                 765             


Ser Leu Thr Trp Thr Leu His His Val Ile Ser Asp Gly Trp Ser Trp 
    770                 775                 780                 


Glu Ile Val Gln Arg Glu Phe Asp Arg Leu His Val Ala Leu Arg Ala 
785                 790                 795                 800 


Gly Arg Phe Arg Pro Leu Pro Pro Pro Val Leu Pro Leu Arg Ala Leu 
                805                 810                 815     


Ala Arg Arg Leu Gly Ser Gly Gly Thr Pro Asp Pro Glu Trp Val Ala 
            820                 825                 830         


Arg Leu Ala Ala Thr Pro Ala Leu Leu Leu Pro Ala Asp Gly Ser Gly 
        835                 840                 845             


Val Gly Gly Glu His Ile Glu Trp Pro Ile Asp Pro Gly Thr His Arg 
    850                 855                 860                 


Glu Leu Ala Ala Arg Ala Gln Ala Ala Glu Ala Ser Pro Ala Ala Ile 
865                 870                 875                 880 


His Leu Leu Ala Phe Thr Glu Ala Leu Arg Arg Val Cys Arg Gln Asp 
                885                 890                 895     


Ser Phe Ala Val Gly Val Val Ser Ser Gly Arg Asn Val Asp Val Pro 
            900                 905                 910         


Gly Val Glu Glu Ala Val Ala Cys Leu Ala Arg Thr Val Pro Leu Pro 
        915                 920                 925             


Val Asp Ala Val Gly Gly Ala Glu Ala Arg Leu Ala Arg Leu His Arg 
    930                 935                 940                 


Asp Leu Ala Val Val Val Gly Met Asp Asp Val Asp Thr Asp Val Leu 
945                 950                 955                 960 


Pro Ala Asp Val Pro Ala Gly Val Arg His Pro Val Ala Thr Phe Val 
                965                 970                 975     


Phe Gln Asn Tyr Pro Asp Ala Ala Val Pro Pro Gly His Arg Pro Leu 
            980                 985                 990         


Pro Glu Val Pro Glu Glu Gly Arg  Trp Arg Glu Ala Gly  Ser Asp Pro 
        995                 1000                 1005             


Leu Ala  Leu Val Cys Phe Glu  Asp Asp Gly Val Pro  Gly Cys Arg 
    1010                 1015                 1020             


Leu Glu  Phe Asp Thr Ala Ala  Val Ser Arg Ala Thr  Ala Glu Leu 
    1025                 1030                 1035             


Val Ala  Arg Glu Val Arg Arg  Ala Gln Asn Arg Leu  Ala Lys Gly 
    1040                 1045                 1050             


Met Gln  Pro 
    1055     


<210>  8
<211>  952
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  8

Met Thr Ala Asp Ala Ala Leu Glu Pro Asp Glu Arg Ala Ala Trp Leu 
1               5                   10                  15      


Ala Tyr Asn Asp Thr Ala Glu Asp Phe Pro Gly Pro His Leu Leu Ala 
            20                  25                  30          


Arg Leu Asp Ala Val Ala Arg Glu His Pro Asp Arg Pro Ala Val His 
        35                  40                  45              


Ala Val Asp Gly Val Trp Thr Tyr Arg Glu Leu His Arg Arg Ala Asp 
    50                  55                  60                  


Ala Val Ala Ala Phe Leu Ala Ala Arg Gly Val Arg Pro Gly Ser Val 
65                  70                  75                  80  


Val Ala Ile Ala Ala Thr Arg Ala Leu Ala Pro Tyr Ala Ala Leu Leu 
                85                  90                  95      


Gly Val Leu Lys Ala Gly Cys Ala Tyr Val Pro Val Asn Pro Asp Asp 
            100                 105                 110         


Pro Ala Asp Arg Val Ala Phe Val Leu Ala Asp Ala Gly Ala Thr Pro 
        115                 120                 125             


Leu Leu Leu Asp Thr Asp Pro Ala Ser Leu Pro Ala Ala Pro Ala Pro 
    130                 135                 140                 


Asp Val Pro His Glu Pro Asp Arg Val Cys Tyr Val Ile Tyr Thr Ser 
145                 150                 155                 160 


Gly Ser Thr Gly Arg Pro Lys Gly Val Val Met Ala Glu Arg Ala Val 
                165                 170                 175     


Asp Asn Leu Thr His Trp Val Val Arg Arg His Asp Val Arg Pro Asp 
            180                 185                 190         


Asp Arg Leu Gly Gln Thr Ala Pro Leu Thr Phe Asp Pro Ser Val Gln 
        195                 200                 205             


Gln Val Phe Pro Ala Trp Ala Thr Gly Ala Cys Leu Val Thr Val Pro 
    210                 215                 220                 


Asp Asp Val Gln Arg Asp Pro Ala Ala Phe Leu Asp Trp Leu Arg Ala 
225                 230                 235                 240 


Glu Arg Val Thr His Leu Asp Leu Val Thr Ser His Trp Val His Leu 
                245                 250                 255     


Leu Asn Ala Ala Glu Ala Arg Pro Ala Glu Leu Pro Asp Leu Arg Trp 
            260                 265                 270         


Ile Ile Ile Gly Gly Glu Thr Tyr Tyr Tyr His Gln Thr His Arg Trp 
        275                 280                 285             


His Arg Val Val Ser Ser Pro Ala Arg Leu Asn Thr Ile Tyr Gly Pro 
    290                 295                 300                 


Thr Glu Ala Ala Val Asn Ala Thr Glu His Leu Thr Glu Pro Asp Leu 
305                 310                 315                 320 


Asp His Gly Gln Val Pro Ile Gly Val Pro Leu Pro Asn Tyr Arg Leu 
                325                 330                 335     


Tyr Ala Leu Asp Asp Asp Gly Arg Leu Cys Pro Pro Gly Ile Thr Gly 
            340                 345                 350         


Glu Ile His Ile Ala Gly Ala Gly Leu Ala Arg Gly Tyr Arg Ser Ala 
        355                 360                 365             


Glu Ala Thr Ala Lys Ala Phe His Glu Leu Glu Val His Ser Gly Arg 
    370                 375                 380                 


Thr Glu Arg Leu Tyr Arg Thr Gly Asp Leu Ala Arg Leu Val Arg His 
385                 390                 395                 400 


Ala Asp Arg Trp Ala Leu Glu Phe Gln Gly Arg Val Asp Ser Gln Val 
                405                 410                 415     


Lys Ile Ser Gly Tyr Arg Val Glu Leu Glu Glu Val Asp Ala Ala Val 
            420                 425                 430         


Lys Ala Val Pro Gly Val Arg Asp Ala Ala Val Val Val Arg Gly Glu 
        435                 440                 445             


Pro Ala Glu Gln Leu Val Cys Cys Tyr Val Gly Asp Val Pro Pro Asp 
    450                 455                 460                 


Arg Leu Arg Ser Arg Leu Thr Glu Arg Leu Pro Ala Tyr Leu Val Pro 
465                 470                 475                 480 


His Leu Leu Val Pro Val Glu Ala Leu Pro Phe Thr Arg Asn Gly Lys 
                485                 490                 495     


Met Asp Thr Ala Glu Leu Ala Glu Leu Val Arg Arg Phe Ala Arg Asp 
            500                 505                 510         


Ser Ala Gly Arg Ala Pro Arg Pro Gly Val Glu Ser Val Val Ala Ala 
        515                 520                 525             


Val Trp Ala Glu Val Leu Asp Leu Pro Glu Val Ser Ala Asp Ala Asp 
    530                 535                 540                 


Phe Leu Gly His Gly Gly Ser Ser Leu Leu Ala Phe Arg Val Val Asp 
545                 550                 555                 560 


Arg Leu Arg Arg Arg Gly Ile Arg Val Arg Pro Ala Asp Val Leu Arg 
                565                 570                 575     


Glu Arg Thr Val Ala Gly Leu Ala Ala Val Ala Glu Glu Asp Leu Val 
            580                 585                 590         


Leu Thr Pro Ser Thr Arg Leu Ala Leu Arg Arg Pro Gly Gly Asn Ala 
        595                 600                 605             


Thr Leu Asp Ile Gly Leu Pro Ala Asp Val Pro Ala Glu Arg Val Arg 
    610                 615                 620                 


Ala Val Leu Glu Asp Ile Val Arg Arg His Pro Val Leu Arg Ala Arg 
625                 630                 635                 640 


Ile Asp Asp Asp Gly Pro Arg Ala Val Pro Val Asp Arg Phe Glu Leu 
                645                 650                 655     


His Thr Pro Asp Gly Pro Val Asp Asp Ala Lys Ala Arg Leu Ala Glu 
            660                 665                 670         


Ser Thr Asp Leu Thr Thr Gly Leu Pro Thr Ala Ala Ala Leu Val Ala 
        675                 680                 685             


Gly Arg Leu Leu Val Ser Ile Arg His Glu Leu Val Asp Gly Ala Ala 
    690                 695                 700                 


Leu Arg Arg Val Ala Glu Glu Val Ala Ala Gly Leu Gly Arg Ala Pro 
705                 710                 715                 720 


Arg Pro Arg Pro Val Val Pro Val Ala Asp Gln Pro Leu Gly Gly Pro 
                725                 730                 735     


Ala Pro Asp Gly Leu Arg Gly His Leu Val Arg Phe Leu Glu Ala Glu 
            740                 745                 750         


Lys Ala Ala Leu Ala Ala Leu Pro Arg Glu His Arg Asp Arg Val Val 
        755                 760                 765             


Glu Val Asp Leu Gly His Ala Pro Asp Ala Leu Leu Asp Thr Pro Pro 
    770                 775                 780                 


Thr Arg Trp His Ala Arg Leu Val Ala Ala Ala Ala Thr Ala Ala Arg 
785                 790                 795                 800 


Ser Trp Leu Gly Leu Val Asp Val Pro Val Gly Val Pro Arg His Trp 
                805                 810                 815     


Pro Gly Ala Gly Gly Ser Val Ala Asn Leu Ala Asp Val Leu Pro Leu 
            820                 825                 830         


Val Val Ala Asp Asp Asp Glu Ala Asp Ala Gln Trp Arg Arg Phe Ala 
        835                 840                 845             


Asp Pro Ala Val His Trp Gly Ala Ala Leu Leu Asp Ala Cys Pro Asp 
    850                 855                 860                 


Leu Ala Asp Asp Trp Pro Ala Pro Arg Ile Ala Pro Gln Gly Ser Phe 
865                 870                 875                 880 


Arg Leu Val Val Thr Ala Asp Asp Glu Pro Leu Ala Pro Asp Leu Pro 
                885                 890                 895     


Leu His Glu Ser Pro Thr Ala Phe Asp Pro Ala Ser Ala Gly Ala Val 
            900                 905                 910         


Glu Phe Ala Val Val Ala Gly Asp Arg Leu Arg Leu His Val Thr Gly 
        915                 920                 925             


Trp Asp Leu Pro Ala Asp Glu Val Lys Ala Val Ala Ala Gly Trp Val 
    930                 935                 940                 


Glu Ala Leu Ala Gly Glu Arg Arg 
945                 950         


<210>  9
<211>  248
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  9

Met Thr Pro Asp Pro His Trp Leu Arg Pro Val Gly Gly Arg Ser Gly 
1               5                   10                  15      


Gly Pro Val Leu Leu Cys Leu Pro His Ala Gly Ala Gly Ala Phe Ala 
            20                  25                  30          


Tyr Ala Gly Trp Asp Arg Gln Asp Ala Phe Asp Val Val Ala Val Gln 
        35                  40                  45              


Pro Pro Gly Arg Glu Asp Arg Phe Ala Glu Gln Pro Ile Thr Asp Pro 
    50                  55                  60                  


Glu His Leu Val Arg Glu Ile Ala Asp Ala Leu Gly Asp Leu Ala Glu 
65                  70                  75                  80  


Gln Pro Leu Ala Leu Phe Gly His Ser Leu Gly Ala Leu Ile Ala His 
                85                  90                  95      


Asp Leu Ala Arg Glu Leu Asp Arg Arg Gly Ala Pro Asp Pro Leu Leu 
            100                 105                 110         


Leu Ala Val Ser Gly His Val Pro Pro His Arg Leu Asp Pro Asp Arg 
        115                 120                 125             


Ala Arg Asp Arg Ser Asp Ala Glu Leu Val Glu His Val Arg Glu Leu 
    130                 135                 140                 


Asp Asp Asp Pro Leu Asp Asp Val Leu Ala Asp Pro Glu Trp Arg Ala 
145                 150                 155                 160 


Met Leu Leu Arg Pro Leu Arg Gly Asp Leu Ala Leu His Asp Ala His 
                165                 170                 175     


Thr His Arg Pro Gly Pro Arg Leu Arg Val Pro Val Leu Ala Leu Thr 
            180                 185                 190         


Gly Ala Asp Asp Asp Ala Thr Pro Ala Glu Asp Thr Ala Ala Trp Ala 
        195                 200                 205             


Glu Leu Thr Glu Gly Pro Phe Ala His Arg Val His Pro Gly Gly His 
    210                 215                 220                 


Phe Tyr Leu Arg Ala Ala Arg Ser Ala Val Leu Asp Asp Leu Ala His 
225                 230                 235                 240 


His Leu Glu Gly Ala Trp Arg Pro 
                245             


<210>  10
<211>  548
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  10

Met Thr Thr Glu Thr Pro Ala Thr Thr Gly Ala Pro Ala Thr Thr Gly 
1               5                   10                  15      


Ala Pro Ala Pro Pro Gly Arg Ala Glu Ile Val Ala Ala Val Leu Pro 
            20                  25                  30          


Val Phe Ala Glu Val Leu Asp Ala Pro Asp Leu Thr Pro Asp Ser Asp 
        35                  40                  45              


Phe Phe Val His Gly Gly Asn Ser Leu Leu Ala Ile Arg Val Ala Gly 
    50                  55                  60                  


Arg Val Gly Arg Arg Leu Gly Arg Gln Val Pro Pro Ala Gly Val Leu 
65                  70                  75                  80  


Lys His Pro Thr Pro Asp Leu Leu Ala Ala His Leu Glu Glu Glu Phe 
                85                  90                  95      


Arg Gly Gly Gly Ala Pro Pro Ile Pro Ala Pro Arg Ala Gly Ala Glu 
            100                 105                 110         


Ala Asp Arg Arg Pro Ser Thr Ala Gln Glu Arg Val Trp Leu Leu His 
        115                 120                 125             


Gln Leu Asp Pro Asp Arg Leu Asp His Leu Val Thr Val Ala Leu Asp 
    130                 135                 140                 


Val Ala Gly Thr Val Asp Pro Ala Ala Phe Thr Ala Ala Trp Thr Ala 
145                 150                 155                 160 


Val Val Arg Arg His Glu Ala Leu Arg Ser Arg Phe Val Lys Ala Asp 
                165                 170                 175     


Asp Asp Arg Val Ala Val Val Val Asp Ala Glu Ala Ala Pro Glu Ile 
            180                 185                 190         


Ser Val Leu Asp Leu Ala Arg Phe Pro Ala Pro Val Arg Asp Arg Leu 
        195                 200                 205             


Ala Glu Glu Arg Val Arg Leu Leu Arg Thr Thr Pro Ile Arg Leu Asp 
    210                 215                 220                 


Thr Gly Pro Leu Ala Arg Phe Ala Leu Leu Arg Leu Ala Asp Arg Arg 
225                 230                 235                 240 


Tyr Arg Ile Glu Leu Ala Val His His Ile Val Cys Asp Gly Trp Ser 
                245                 250                 255     


Leu Asp Thr Leu Leu Ala Asp Phe Leu Asp Ala Tyr Gly Arg Ala Leu 
            260                 265                 270         


Ala Gly Arg Ser Pro Ala Leu Pro Pro Pro Ala Val Gly Phe Ala Asp 
        275                 280                 285             


Tyr Val Ala Trp Glu Arg Asp Val Glu Ser Ser Arg Trp Pro Asp Met 
    290                 295                 300                 


Ala Val Arg Leu Ala Arg Arg Phe Ala Asp Arg Pro Ala Asp Leu Pro 
305                 310                 315                 320 


Leu Pro Val Asp Pro Val Asp Val Pro Ala His Glu Asp Gly Asp Asp 
                325                 330                 335     


Val Thr Val His Ala Pro Pro Gly Leu Ala Ala Ala Val Glu Arg Ala 
            340                 345                 350         


Arg Thr Ser Phe Gly His Thr Ala Leu Thr Phe His Leu Thr Ala Leu 
        355                 360                 365             


Gly Val Leu Leu Ala Arg Ile Thr Gly Val Asp Asp Leu Val Val Ala 
    370                 375                 380                 


Val Pro Val Ala Gly Arg Ala Gln Thr Glu His Glu Asp Leu Val Gly 
385                 390                 395                 400 


Leu Phe Val Asn Thr Ala Leu Ala Arg Val Arg Leu Gly Gly Thr Ser 
                405                 410                 415     


Asp Val Arg Val Leu Leu Glu Arg Asn Arg Asp Glu Val Asp Glu Leu 
            420                 425                 430         


Val Asp Cys Gln Thr Phe Pro Phe Asp Arg Leu Val Asp Leu Leu Gly 
        435                 440                 445             


Ala Arg Arg Ala Gly Thr Arg Val Pro Leu Ala Arg Val Ser Leu Ala 
    450                 455                 460                 


Val Gln Asn Phe Asp Asp Pro Gly Thr Pro Ala Pro Glu Leu Gly Phe 
465                 470                 475                 480 


Thr Trp Gln Phe Arg Asp Pro Pro Glu Arg Gln Ser Lys Phe Asp Leu 
                485                 490                 495     


Ala Phe Thr Val Ser Asp Thr Asp Gly Leu Arg Leu Thr Val Thr Tyr 
            500                 505                 510         


Arg Pro Ser Leu Phe Arg Arg Ala Thr Val Ala Ala Trp Ala Gly Gln 
        515                 520                 525             


Tyr Leu Val Ala Leu Glu His Val Val Arg Gly Val Ala Asp Pro Glu 
    530                 535                 540                 


Gly Ser Ala Arg 
545             


<210>  11
<211>  383
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  11

Met Lys Leu Asn Arg Gln His Glu Leu Phe Arg Glu Ser Val Arg Met 
1               5                   10                  15      


Val Leu Asp Arg Glu Cys Val Glu Leu Val Asp Asp Trp Glu Arg Asp 
            20                  25                  30          


Gly Val Met Pro Val His Gln Leu Cys Lys Thr Leu Ala Ala Glu Gly 
        35                  40                  45              


Leu Leu Gly Leu Thr Met Pro Val Glu Asp Gly Gly Leu Gly Leu Asp 
    50                  55                  60                  


Leu Gly Tyr Ser Tyr Val Trp Ala Gln Glu Leu Gly Arg Val Pro Ala 
65                  70                  75                  80  


Gly Ala Pro Ala Met Ala Leu Ser Val Gln Thr Asp Ile Val Ala Pro 
                85                  90                  95      


Leu Leu Ala Arg Ala Gly Thr Pro Glu Val Arg Arg Asp Val Leu Arg 
            100                 105                 110         


Pro Ala Ile Arg Gly Glu Leu Val Ala Ala Leu Ala Ala Thr Glu Pro 
        115                 120                 125             


Ala Gly Gly Ser Asp Leu Gly Ala Leu Thr Thr Thr Ala Val Arg Thr 
    130                 135                 140                 


Glu Arg Gly Phe Thr Val Asn Gly Thr Lys Ala Phe Ile Thr Asn Gly 
145                 150                 155                 160 


Ser Val Ala Asp Phe Ala Val Val Leu Cys Arg Thr Gly Glu Ala Ala 
                165                 170                 175     


Gly Ile Gly Asp Leu Ala Leu Leu Val Val Pro Thr Asn Leu Ala Gly 
            180                 185                 190         


Val Arg Gln Val Arg His Thr Gly Lys Leu Gly His Arg Ser Cys Asp 
        195                 200                 205             


His Gly Thr Leu Thr Phe Thr Asp Val Glu Val Pro Ala Ala Tyr Leu 
    210                 215                 220                 


Leu Gly Glu Val Gly Glu Gly Tyr Glu Leu Gln Thr Arg Thr Phe Thr 
225                 230                 235                 240 


Arg Glu Arg Cys Phe Leu Ala Val Val Ala Leu Gly Gln Ala Glu Arg 
                245                 250                 255     


Val Leu Arg Ala Thr Val His His Ala Arg Arg Arg Arg Val Leu Gly 
            260                 265                 270         


Arg Ala Leu Thr Asp His Gln Ala Ile Gly Phe Arg Leu Ala Glu Leu 
        275                 280                 285             


Asp Ala Glu Leu Asp Leu Val Arg Ser Tyr Ala Gly Glu Ala Tyr Gln 
    290                 295                 300                 


Leu Leu Ala Asp Gly Ala Gln Cys Leu Arg Glu Ala Ser Ile Ala Lys 
305                 310                 315                 320 


Leu Arg Ala Thr Arg Leu Leu Arg Glu Val Ala Asp Val Gly Leu Gln 
                325                 330                 335     


Val Arg Gly Ala Ala Gly Tyr Leu Gly Val Asp Asp Val Glu Arg Thr 
            340                 345                 350         


Tyr Arg Asp Ala Arg Ala Gly Ser Phe Ala Gly Gly Ala Asp Glu Ala 
        355                 360                 365             


Leu Leu His Leu Ile Ala Gly His Leu Thr Gly Thr Glu Gln Glu 
    370                 375                 380             


<210>  12
<211>  332
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  12

Met Thr Pro Ser Glu Glu Leu Leu Phe Leu Asp Arg Glu Thr Val Arg 
1               5                   10                  15      


Ala Cys Val Ala Gly Val Asp Pro Val Glu Val Val Glu Ser Val Leu 
            20                  25                  30          


Arg Ser His Ala Ala Gly Arg Thr Thr Leu Pro Ala Glu Gly Tyr Leu 
        35                  40                  45              


Pro Trp Glu Asn Asp Gln Gly Ala Tyr Cys Arg Ser Ile Ala Met Leu 
    50                  55                  60                  


Gly Ala Val Asp Gly Glu Arg Gly Pro Thr Tyr Gly Ile Lys Leu Ile 
65                  70                  75                  80  


Asn Ala Ala Val Ser Asn Pro Ser Ile Gly Leu Asp Arg Ala Gly Gly 
                85                  90                  95      


Cys Gly Phe Leu Phe Asp Pro Arg Thr Ala Arg Pro Val Val Leu Ala 
            100                 105                 110         


Glu Ala Ala Tyr Leu Ser Gly Leu Arg Thr Ala Ala Tyr Thr Met Ala 
        115                 120                 125             


Ser Leu Arg His Leu Gly Pro Val Gly Phe Asp Ala Val Ser Phe Ile 
    130                 135                 140                 


Gly Thr Gly Ala Gln Ala Arg Val His Ala Ala Leu Leu Ala Arg Tyr 
145                 150                 155                 160 


Phe Pro Ala Val Arg Asp Leu His Val Phe Asp Thr Glu Arg Ser Arg 
                165                 170                 175     


Ala Glu Ala Phe Thr Gly Ala Ser Gly His Thr Val His Val His Asp 
            180                 185                 190         


Thr Ala Glu Ala Ala Val Arg Ala Ser His Val Leu Val Thr Leu Thr 
        195                 200                 205             


Thr Val Asp Asp Gly Tyr Ile Pro His Asp Trp Phe Arg Pro Gly Ser 
    210                 215                 220                 


Phe Val Ala His Val Ser Leu Asp Asp Leu Leu Pro Glu Val Phe Phe 
225                 230                 235                 240 


Lys Ser Glu Ala Leu Phe Val Asp Asp Leu Glu Leu Ile Arg Glu Asn 
                245                 250                 255     


Pro Arg Arg Val Leu Gly Ala Leu Leu Ala Asp Gly Asp Val Pro Val 
            260                 265                 270         


Thr Gly Ser Leu Gly Gly Val Leu Thr Gly Ala Val Ala Pro Val Arg 
        275                 280                 285             


Pro Arg Asp Gly Val Val Val Ser Asn Pro Phe Gly Met Ala Val Leu 
    290                 295                 300                 


Asp Val Gly Leu Leu Ala Glu Val Ala Ala His Ala Arg Ser Ala Gly 
305                 310                 315                 320 


Leu Gly Thr Thr Leu Asp Leu Leu Gly Ala Ala Arg 
                325                 330         


<210>  13
<211>  295
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  13

Met Thr Gly Leu Tyr Ser Leu Ala Asp Leu Ser Pro Ala Asp Val Leu 
1               5                   10                  15      


Ala Leu Ala Asp Arg Ser Val Gln Leu His Arg Asp Arg Thr Ala His 
            20                  25                  30          


Asp Arg Pro Leu Thr Asp Leu Val Val Gly Thr Leu Phe Thr Lys Thr 
        35                  40                  45              


Ser Thr Arg Thr Arg Thr Ala Phe Thr Thr Ala Ala Leu Arg Leu Gly 
    50                  55                  60                  


Ala Ser Val Val Ala Phe Gly Pro Asp Glu Leu Gln Thr Ala Thr Gly 
65                  70                  75                  80  


Glu Ser Thr Ala Asp Thr Gly Arg Val Leu Ala Ser Met Leu Asp Gly 
                85                  90                  95      


Leu Val Val Arg Thr Ala Gly Pro Val Ala Arg Gln Arg Glu Leu Ser 
            100                 105                 110         


Gly Gly Gly Val Leu Pro Val Val Asn Ala Met Ser Arg Glu Glu His 
        115                 120                 125             


Pro Thr Gln Gly Leu Thr Asp Leu Ala Val Leu Arg His His Phe Gly 
    130                 135                 140                 


Asp Leu Ala Gly Val Arg Val Leu Tyr Val Gly Glu Gly Asn Asn Thr 
145                 150                 155                 160 


Ala Ala Ala Leu Val His Ala Leu Ala Ala Val Pro Gly Cys Glu Leu 
                165                 170                 175     


Val Leu Ala Cys Pro Lys Gly Tyr Gly Pro Arg Asp Pro Gly Pro Trp 
            180                 185                 190         


Arg Glu Val Ala Asp Leu Ala Glu Val Thr Gly Asp Val Asp Val Val 
        195                 200                 205             


Tyr Thr Thr Arg Trp Gln Thr Thr Gly Thr Ala Lys Ala Asp Pro Asp 
    210                 215                 220                 


Trp Arg Glu Ala Phe Arg Pro Phe His Val Asp Thr Ala Leu Met Asp 
225                 230                 235                 240 


Arg Trp Pro Asp Ala Val Phe Leu His Asp Leu Pro Ala His Arg Gly 
                245                 250                 255     


Glu Glu Val Ala Gly Ala Val Leu Asp Gly Ala Arg Ser Leu Ala Trp 
            260                 265                 270         


Thr Gln Ala Ala Met Lys Ala Ala Ser Ala Met Ala Val Leu Glu Arg 
        275                 280                 285             


Phe Val Gly Gly Arg Arg Ala 
    290                 295 


<210>  14
<211>  401
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  14

Met Leu Asp Leu Ser Pro Ala Gln Arg Ser Leu Trp Val Leu His Gln 
1               5                   10                  15      


Leu Asp Asp Thr Gly Phe Thr Leu Ser Ser Ala His Arg Leu Arg Gly 
            20                  25                  30          


Pro Phe Asp Leu Gly Ala Phe Thr Ala Ala Val Asp Ala Val Val Ala 
        35                  40                  45              


Arg His Ser Pro Leu Arg Thr Arg Phe Pro Val Gly Thr Asp Gly Gly 
    50                  55                  60                  


Pro Asp Pro Val Val Asp Pro Pro Gly Pro Val Val Val Glu Ala Val 
65                  70                  75                  80  


Ala Ala Glu Gly Phe Thr Ala Ala His Ala Glu Ala Ala Arg Phe Cys 
                85                  90                  95      


Ala Arg Pro Phe Asp Leu Ala Arg Glu Trp Pro Leu Arg Val Leu Val 
            100                 105                 110         


Val Arg Leu Ser Thr Glu Asp His Val Val Ala Leu Ala Val His His 
        115                 120                 125             


Ile Ser Cys Asp Gly Val Ser Leu Gly Leu Leu His Asp Glu Leu Ser 
    130                 135                 140                 


Arg Leu Tyr Asp Gly Ala Glu Leu Pro Pro Val Ala Asp His Arg Glu 
145                 150                 155                 160 


Leu Val Ala Arg Arg Ala Val Asp Pro Ala Ala Val Ala Arg Cys Arg 
                165                 170                 175     


Asp Arg Leu Ala Gly Val Pro Pro Leu Ala Ala Asp Arg Pro Ala Val 
            180                 185                 190         


Arg Ser Gly Lys Gly Asp Gln Val Trp Phe Thr Val Pro Ala Asp Leu 
        195                 200                 205             


Thr Gly Ala Val Arg Ala Cys Ala Arg Arg His Arg Val Thr Ala Phe 
    210                 215                 220                 


Met Val Leu Leu Ala Ala Phe Gln Leu Val Leu His Arg Arg Thr Gly 
225                 230                 235                 240 


Gln Thr Asp Phe Ala Val Gly Val Pro Val Ala Gly Arg Gly Asp Pro 
                245                 250                 255     


Asp Ser Glu Asn Val Ile Gly Leu Phe Thr Asn Thr Val Val Val Arg 
            260                 265                 270         


Ala Asp Leu Ala Gly Glu Pro Gly Pro Ala Glu Val Leu Arg Arg Val 
        275                 280                 285             


Arg Glu Ala Ala Phe Asp Ala Phe Ala Asp Gln Asp Val Pro Leu Gly 
    290                 295                 300                 


Ala Val Val Ala Ala Val Gly Glu Pro Pro Asp Pro Ala Arg Thr Pro 
305                 310                 315                 320 


Leu Phe Gln Ala Leu Phe Thr Phe Gln Asp Ala Pro Val Gly Arg Leu 
                325                 330                 335     


Ala Leu Pro Gly Val Arg Cys Val Glu Leu Asp Leu Pro Thr Gly Ala 
            340                 345                 350         


Ala Ala Ser Asp Leu Glu Leu Glu Leu Val Arg Asp Gly Asp Glu Leu 
        355                 360                 365             


Ala Gly Ser Leu Glu Tyr Ser Thr Asp Leu His Asp Ser Gly Thr Ala 
    370                 375                 380                 


Ala Ala Leu Thr Ala Asp Phe Leu Ala Val Leu Asp Glu Ile Thr Ala 
385                 390                 395                 400 


Glu 
    


<210>  15
<211>  62
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  15

Met Asp Thr Tyr Leu Val Val Val Asn His Glu Glu Gln Tyr Ser Val 
1               5                   10                  15      


Trp Pro Ala Asp Arg Pro Leu Pro Ala Gly Trp Arg Ala Glu Gly Thr 
            20                  25                  30          


Ser Gly Asp Lys Glu Gln Cys Leu Ala His Ile Glu Thr Val Trp Thr 
        35                  40                  45              


Asp Met Arg Pro Leu Ser Val Arg Arg Arg Ala Glu Ala Val 
    50                  55                  60          


<210>  16
<211>  584
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  16

Met Thr Ala Leu His Arg Leu Asp Gln Leu Ala Gly Ala Arg Pro Asp 
1               5                   10                  15      


Ala Pro Ala Leu Leu Asp Glu Ala Glu Thr Val Ser Tyr Gly Arg Leu 
            20                  25                  30          


Trp Arg Glu Leu Thr Gly Val Ala Gly Ala Leu Arg Ala Ala Gly Val 
        35                  40                  45              


Arg Arg Gly Asp Arg Val Val Val Pro Ala Asp Arg Thr Trp Gln Gly 
    50                  55                  60                  


Ile Val Ser Met Leu Gly Val Leu Arg Ala Gly Ala Ala Tyr Val Pro 
65                  70                  75                  80  


Val Asp Ala Gly Asp Pro Val Glu Arg Leu Arg His Val Val Arg Thr 
                85                  90                  95      


Ala Gly Ala Ala Trp Val Thr Gly Arg Ala Glu Ala Leu Ala Ala Leu 
            100                 105                 110         


Pro Asp Leu Gly Leu His Pro Ile Pro Phe Gly Ser Ala Pro Asp Ser 
        115                 120                 125             


Ala Ser Arg Ser Ala Ser Gly Ser Asp Ser Gly Ser His Ser Ala Ser 
    130                 135                 140                 


Gly Gly Val Gly Gly Leu Pro Asp Pro Glu Asp Leu Ala Tyr Val Met 
145                 150                 155                 160 


Phe Thr Ser Gly Ser Thr Gly Thr Ala Lys Ala Val Met Val Pro His 
                165                 170                 175     


Arg Ser Ile Ala His Ala Ala Pro Ser Leu Ala Arg Arg Cys Gly Ile 
            180                 185                 190         


Thr Pro Asp Asp Arg Phe Leu Ser Trp Ala Ser Leu Val Trp Asp Thr 
        195                 200                 205             


Ser Gly Glu Glu Leu Tyr Ser Thr Leu Leu Ser Gly Ala Gly Leu Val 
    210                 215                 220                 


Leu Asp Arg Glu Ala Thr Ser Gly Ser Val Pro Ala Leu Leu Arg Ala 
225                 230                 235                 240 


Val Glu Arg Arg Ser Val Ser Val Val Asp Leu Pro Thr Ala Phe Trp 
                245                 250                 255     


Asn Gln Val Val Asp Tyr Leu Glu Thr Thr Gly Glu Ala Val Pro Glu 
            260                 265                 270         


Cys Leu Arg Leu Val Val Val Gly Gly Glu Glu Val Arg Ala Arg Gln 
        275                 280                 285             


Val Arg Val Trp Ala Glu Arg Ala Pro Asp Val Arg Leu Leu Asn Thr 
    290                 295                 300                 


Tyr Gly Gln Thr Glu Thr Val Met Val Thr His Ala Ala Asp Ile Gly 
305                 310                 315                 320 


Gly Leu Ala Pro Pro Asp Gly Gly Ala Val Pro Ile Gly His Pro Leu 
                325                 330                 335     


Pro His Val Arg Gln His Leu Glu Pro Val Gly Asp Gly Leu Phe Glu 
            340                 345                 350         


Leu His Val Gly Gly Pro Thr Leu Ala Trp Gly Tyr Arg Asp Arg Pro 
        355                 360                 365             


Ala Ala Thr Ala Glu Arg Phe Pro Pro Asp Glu Arg Gly Arg Arg Phe 
    370                 375                 380                 


Arg Thr Gly Asp Leu Val Arg Val Ala Asp Asp Gly Ala Leu Val Phe 
385                 390                 395                 400 


Val Gly Arg Ala Asp Arg Gln Val Lys Val Arg Gly Val Arg Val Glu 
                405                 410                 415     


Pro Ala Glu Val Glu Arg Ala Leu Met Ala Cys Pro Gly Val Thr Ala 
            420                 425                 430         


Ala Ala Ala Phe Val Val Asp Asn Ala Ser Asp Gly Val Leu Leu Val 
        435                 440                 445             


Gly Ala Phe Val Pro Gly Asp Gly Asp Ala Thr Pro Ala Thr Val Ala 
    450                 455                 460                 


Ala Ala Leu Arg Thr Arg Leu Ser Pro Ala Leu Leu Pro His Arg Leu 
465                 470                 475                 480 


Val Ser Val Pro Ser Met Pro Leu Leu Thr Thr Gly Lys Ile Asp Gln 
                485                 490                 495     


Ala Ala Leu Val Glu Arg Phe Ala Arg Ser Asp Val Ala Pro Gly Ala 
            500                 505                 510         


Gly Leu Ala Gly Gln Leu Ala Val Val Phe Ser Glu Val Leu Gly Thr 
        515                 520                 525             


Pro Cys Ala Ala Asp Asp Asp Phe Phe Asp Gln Gly Gly Asp Ser Val 
    530                 535                 540                 


Val Ala Thr Arg Leu Leu Thr Arg Ile Arg Arg Ser Tyr Arg Val Glu 
545                 550                 555                 560 


Leu Thr Phe Arg Asp Val Phe Asp His Pro Ser Pro Thr Ala Leu Ala 
                565                 570                 575     


Gly Leu Ile Ser Arg Thr Pro Arg 
            580                 


<210>  17
<211>  448
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  17

Met Pro Val Gln Pro His Glu His Val Arg Arg Thr Pro Val Glu Pro 
1               5                   10                  15      


Ser Trp Arg Arg Phe Pro Gly Trp Arg Asp Val Thr Arg Glu Gln Trp 
            20                  25                  30          


Arg Asp Pro Arg Trp Gln Arg Val His Cys Val Arg Asn Thr Arg Gln 
        35                  40                  45              


Leu Arg Ala Val Val Gly Asp Leu Leu Asp Glu Arg Phe Tyr Asp Asp 
    50                  55                  60                  


Leu Ala Ala Asp Gln Glu Ser Phe Ala Thr Met Ser Met Leu Leu Pro 
65                  70                  75                  80  


Pro Gln Met Leu Asn Thr Met Val Pro Glu Gly Ala Ala Asp Phe Thr 
                85                  90                  95      


Gly Ala Phe Tyr Ala Asp Pro Val Arg Arg Tyr Met Leu Pro Val Arg 
            100                 105                 110         


Ser Asp Arg Asp Pro Glu Trp Pro Ser His Pro Tyr Ser Ser Arg Asp 
        115                 120                 125             


Ser Leu His Glu Ala Glu Met Trp Val Val Glu Gly Leu Thr His Arg 
    130                 135                 140                 


Tyr Pro Thr Lys Val Leu Ala Glu Leu Val Ser Thr Cys Pro Gln Tyr 
145                 150                 155                 160 


Cys Gly His Cys Thr Arg Met Asp Leu Val Gly Asn Ser Thr Pro Gln 
                165                 170                 175     


Val Arg Lys His Lys Leu Glu Leu Lys Pro Val Asp Arg Gln Asp Arg 
            180                 185                 190         


Met Leu Asp Tyr Leu Arg Arg Thr Pro Ala Val Arg Asp Val Val Val 
        195                 200                 205             


Ser Gly Gly Asp Val Ala Asn Val Pro Trp Pro Gln Leu Glu Ser Phe 
    210                 215                 220                 


Leu Ala Arg Leu Leu Glu Ile Glu Thr Val Arg Asp Ile Arg Leu Ala 
225                 230                 235                 240 


Thr Lys Ala Leu Ala Gly Leu Pro Gln His Trp Leu Gln Pro Gln Val 
                245                 250                 255     


Val Glu Gly Met Ser Arg Val Ala Arg Thr Ala Ala Ser Arg Gly Val 
            260                 265                 270         


Asn Leu Ala Val His Thr His Val Asn His Ala Gln Ser Val Thr Pro 
        275                 280                 285             


Leu Val Ala Glu Ala Ala Arg Ala Leu Leu Asp Ala Gly Val Arg Asp 
    290                 295                 300                 


Val Arg Asn Gln Gly Val Leu Met Arg Gly Val Asn Ala Thr Pro Asp 
305                 310                 315                 320 


Asp Leu Leu Glu Leu Cys Phe Ala Leu Gln Gly Glu Ala Asn Ile Leu 
                325                 330                 335     


Pro Tyr Tyr Phe Tyr Leu Cys Asp Met Ile Pro Asn Ala Glu His Trp 
            340                 345                 350         


Arg Thr Ser Val Ala Glu Ala Gln Asp Leu Gln Ala Ala Ile Met Gly 
        355                 360                 365             


Tyr Leu Pro Gly Tyr Ala Thr Pro Arg Ile Val Cys Asp Val Pro Tyr 
    370                 375                 380                 


Val Gly Lys Arg Trp Val His Gln Val Val Glu Tyr Asp Arg Glu Leu 
385                 390                 395                 400 


Gly Val Ser Tyr Trp Thr Lys Asn Tyr Arg Thr Gly Ile Glu Ser Asp 
                405                 410                 415     


Asp Pro Asn Ala Leu Asp Arg Arg Tyr Pro Tyr Tyr Asp Pro Ile Ser 
            420                 425                 430         


Thr Leu Gly Glu Thr Gly Arg Arg Trp Trp Arg Lys His Glu Arg Ala 
        435                 440                 445             


<210>  18
<211>  237
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  18

Met Leu Thr Pro Ala Gly Ala Gly Arg Ala Arg Arg Gly Ile Ala Val 
1               5                   10                  15      


Leu Leu Ala Asp Asp His Glu Val Ile Leu Asp Gly Leu Arg Ala Val 
            20                  25                  30          


Leu Ala Arg Asp Asp Ala Ile Thr Val Val Gly Ala Val His Gly Val 
        35                  40                  45              


Pro Glu Leu Leu Asp Arg Ile Gly Arg Asp Gln Pro Asp Val Val Leu 
    50                  55                  60                  


Val Gly Ala Ser Leu Leu Arg Val Asp Asp Phe Arg Val Ala Arg Leu 
65                  70                  75                  80  


Leu Ala Gly Gln Arg Val Val Val Ala Thr Gln Asp Asp Ser Asp Glu 
                85                  90                  95      


Leu Leu Val Ser Ala Ile Ala Ala Gly Val Ser Gly Tyr Leu Pro Leu 
            100                 105                 110         


Gly Ser Pro Gly Glu Glu Phe Pro Arg Ala Ile Arg Ala Val Ala Glu 
        115                 120                 125             


Gly Gly Ala Tyr Leu Pro Ala His Val Thr Lys Arg Val Phe Glu Ser 
    130                 135                 140                 


Phe Gln Ile Ile Pro Leu Pro Asp Pro Ser Ala Pro Ala Leu Leu Ser 
145                 150                 155                 160 


Leu Thr Glu Arg Glu Gly Gln Val Leu Arg Ala Ile Gly Gln Gly Arg 
                165                 170                 175     


Ser Asn Arg Glu Ile Ala Arg Glu Phe Glu Val Ser Glu Thr Thr Val 
            180                 185                 190         


Lys Ser His Val Ser Arg Val Leu Ala Lys Leu Glu Leu Arg Asp Arg 
        195                 200                 205             


Val Gln Ala Ala Leu Leu Ala Trp Arg Leu Gly Leu Val Thr Ala Arg 
    210                 215                 220                 


Glu Ala Pro Glu Val Val Lys Pro Arg Gly Ala Ser Ala 
225                 230                 235         


<210>  19
<211>  239
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  19

Met Pro Ser Glu Gly Leu Val Lys Val Val Gly Lys Arg Cys Val Pro 
1               5                   10                  15      


Leu Ala Asp Ala Glu Phe Ala Glu Leu Arg Ala Arg His Arg Ser Val 
            20                  25                  30          


Leu Leu Asp Val Gly Thr Gly Asp Gly Lys His Ala Tyr Arg Leu Ala 
        35                  40                  45              


Arg Ala Asp Pro Asp Arg Leu Val Val Gly Val Asp Ala Asn Pro Asp 
    50                  55                  60                  


Arg Met Arg Gly Val Ser Ala Arg Ala Ala Ala Lys Pro Ala Arg Gly 
65                  70                  75                  80  


Gly Leu Pro Asn Leu Val Leu Val His Ala Ala Ala Glu Glu Met Pro 
                85                  90                  95      


Pro Cys Leu Gly Asp Val Asp Glu Met His Val Leu Met Pro Trp Gly 
            100                 105                 110         


Ser Leu Leu Arg Gly Val Leu Gly Arg Asp Pro Ala Val Leu Ala Gly 
        115                 120                 125             


Leu Ala Gly Ala Cys Arg Ala Gly Ala Arg Phe His Ile Thr Val Asn 
    130                 135                 140                 


Leu His Ala Trp Arg Pro Ala Ala Pro Ala Val Thr Gly Ile Ala Glu 
145                 150                 155                 160 


Pro Thr Pro Glu Trp Val Arg Arg Glu Leu Ala His Val Tyr Ala Glu 
                165                 170                 175     


Ala Gly Leu Arg Val Thr Arg Ala Gly Tyr Leu Ala Asp Val Gly Ala 
            180                 185                 190         


Ser Glu Leu Thr Ser Thr Trp Thr Arg Arg Leu Gly Ala Cys Arg Glu 
        195                 200                 205             


Glu Phe Asp Val Leu Gly Val Glu Gly Ala Ala Arg Gly Gly Ser Thr 
    210                 215                 220                 


Pro Gly Val Ala Gly Ile Thr Ser Lys Ala Ala Cys Leu Pro Ala 
225                 230                 235                 


<210>  20
<211>  281
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  20

Met Thr Leu Ser His Leu Val Asp Val Val Arg Arg Ala His Pro Asp 
1               5                   10                  15      


Val Asp Leu Glu Gly Ala Gly Val His Ser Gly Gln Phe His Asp Val 
            20                  25                  30          


Leu Ile Ala Arg Asp Arg Val Phe Arg Phe Pro Lys Thr Ala Gly Ala 
        35                  40                  45              


Ala Ala Glu Leu Pro Gly Arg Val Ala Val Leu Thr Ala Val Asp Ala 
    50                  55                  60                  


Val Glu Leu Gly Val Gly Val Pro Val Pro Leu Ser Glu Val Arg Asp 
65                  70                  75                  80  


Gly Gly Pro His Gly Phe Leu Val Leu Ser Arg Leu His Gly Thr Pro 
                85                  90                  95      


Leu Glu Arg Gly Asp Ala Thr Ser Pro Glu Val Ile Asp Val Val Ala 
            100                 105                 110         


Ala Glu Phe Ala Arg Val Leu Arg Ala Met Ala Gly Ala Asp Val Glu 
        115                 120                 125             


Lys Leu Arg Leu Val Leu Pro Val Ala Asp Ala Gly Arg Trp Arg Gly 
    130                 135                 140                 


Phe Ala Gly Arg Val Arg Ala Thr Leu Phe Pro Leu Met Ser Glu Asp 
145                 150                 155                 160 


Gly Arg Ala Arg Ala Glu Arg Glu Leu Ala Ala Ala Val Ala Met Asp 
                165                 170                 175     


His Val Ala Thr Gly Leu Val His Gly Asp Leu Gly Gly Glu Asn Val 
            180                 185                 190         


Leu Trp Gln Gln Val Glu Glu Leu Pro Arg Leu Thr Gly Ile Val Asp 
        195                 200                 205             


Trp Asp Glu Ala Lys Val Gly Asp Pro Ala Glu Asp Leu Ala Ala Val 
    210                 215                 220                 


Gly Ala Ser Tyr Gly Pro Glu Leu Val Glu Arg Val Val Ala Leu Leu 
225                 230                 235                 240 


Gly Ala Gly Asp Leu Trp Pro Arg Ile Arg Ala Tyr Gln Gly Thr Phe 
                245                 250                 255     


Ala Leu Gln Gln Ala Leu Ala Gly Ala Glu Asp Gly Asp Asp Glu Glu 
            260                 265                 270         


Leu Glu Asp Gly Leu Thr Ala Tyr Arg 
        275                 280     


<210>  21
<211>  167
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  21

Met Ser Arg Trp Cys Gly Gly Met Pro Asp Gly Gly Asp Val Val Met 
1               5                   10                  15      


Ser Ser Gln Ser Trp Asp Ala Gly Asp Glu Ser Gly Asp Glu Val Val 
            20                  25                  30          


Leu Ala Leu Asp Gly Val Ala Val Arg Glu Val Arg Asp Leu Val Arg 
        35                  40                  45              


Asp Leu Leu Ser Asp Arg Ala Gly Val Ala Val Asp Asp Ala Val Leu 
    50                  55                  60                  


Val Val Asp Glu Leu Val Ser Asn Ala Leu Arg His Gly Glu Pro Pro 
65                  70                  75                  80  


Arg Arg Cys Arg Leu Val Arg Ala Gly Gln Arg Leu Arg Val Glu Val 
                85                  90                  95      


Asp Asp Ala Gly Ser Gly Gln Pro Arg Ile Arg Thr Ala Asp Ala Ser 
            100                 105                 110         


Gly Gly Arg Gly Leu Val Ile Val Gln Ala Leu Ser Thr Asp Trp Gly 
        115                 120                 125             


Val Val Arg His Pro Glu His Lys Thr Val Trp Ala Glu Val Leu Leu 
    130                 135                 140                 


Ala Gly Gln Ser Arg Pro Ser His Val Ala Pro Ala Gln Thr Trp Gly 
145                 150                 155                 160 


Asp Thr Pro Ala Gln Gly Arg 
                165         


<210>  22
<211>  190
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  22

Met Thr Ser Thr Glu Asn Asp Leu Leu Leu Asp Lys Ile Gly Arg Gly 
1               5                   10                  15      


Phe Asp His Leu Asp Ala Asp Gly Asp Gly Leu Leu Asp Glu Arg Asp 
            20                  25                  30          


His Val Leu Met Gly Glu Arg Val Ala Ala Ala Leu Gly His Gly Ser 
        35                  40                  45              


Gly Ser Ala Glu Glu Glu Arg Ile Val Asp Met Tyr Val Arg Val Trp 
    50                  55                  60                  


His Asp Val His Leu Pro His Leu Pro Ala Gly Thr Thr Ala Ile Gly 
65                  70                  75                  80  


Arg Asp Glu Phe Ile Ala Ala Thr Arg Asp Leu Ala Asp Asp Pro Ala 
                85                  90                  95      


Ala Ala Asp Ala Thr Leu Gly Ala Leu Ala Arg Glu Phe Leu Arg Ile 
            100                 105                 110         


Ala Asp Ile Asp Ala Asp Gly Arg Val Thr Pro Ala Glu Phe Leu Thr 
        115                 120                 125             


Phe Gln Arg Gly His Phe Pro Asp Leu Ser Asp Glu Asp Ala Ala Ala 
    130                 135                 140                 


Ala Phe Glu His Leu Asp Thr Asp Gly Asp Gly Ser Leu Ser Pro Glu 
145                 150                 155                 160 


Glu Phe Ile Arg Ala Thr Val Glu Tyr Trp Thr Ser Thr Asp Pro Asp 
                165                 170                 175     


Ser Pro Ala Asn Trp Trp Ile Gly Arg Pro Arg Pro Thr Ala 
            180                 185                 190 


<210>  23
<211>  246
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  23

Met Gly Val Thr Ala Ala Pro Leu Ala Ser Met Gly Pro Thr Arg Ser 
1               5                   10                  15      


Arg Ser Thr Pro Thr Ile Gly Gly Gln Pro His Leu Glu Arg Asp Arg 
            20                  25                  30          


Ala Arg Val Arg Gly Met Val Arg Leu Gly Val Val Ala Leu Leu Leu 
        35                  40                  45              


Ala Thr Val Ala Ser Ala Cys Ala Ala Glu Glu Pro Glu Tyr Val Ser 
    50                  55                  60                  


Leu Ile Glu Ala Cys Asp Leu Val Asp Pro Gly Thr Val Thr Ala Leu 
65                  70                  75                  80  


Ser Arg Gly Leu Pro Ala Ala Pro Pro Ser Arg Glu Pro Val Arg Phe 
                85                  90                  95      


Ser Asp Asp Arg Val Asp Met Val Glu Cys Arg His Glu Phe Gly Asp 
            100                 105                 110         


Ser Gly Asn Val Pro Val Leu Pro His Asp Asp Trp Ala Pro Asp Thr 
        115                 120                 125             


Pro Gly Thr Pro Leu Tyr Arg Tyr Val Thr Val Thr Val Met Arg Tyr 
    130                 135                 140                 


Arg Ala Gly Asp Gly Arg Ser Ala Thr Gly Asn Ala Arg His His Leu 
145                 150                 155                 160 


Ala Ser Asp Pro Gln Ala Lys Asp Pro Ala Ile Thr Gly Ala Gly Leu 
                165                 170                 175     


Asp Asp Gly Asp Val Met His Lys Tyr Asn Gly Val Gln Ser Tyr Ser 
            180                 185                 190         


Arg Val Arg Ala Val Asp His Asn Val Phe Leu Thr Val Glu Tyr Gly 
        195                 200                 205             


Gly Ala Asn Gly Asn Ala Arg Pro Gln Gly Met Pro Ala Asp Glu Ser 
    210                 215                 220                 


Arg Glu Gly Ala Leu Arg Leu Leu Thr Gly Ala Ala Ser Arg Leu Pro 
225                 230                 235                 240 


Cys Pro Lys Pro Gly Cys 
                245     


<210>  24
<211>  427
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  24

Met Lys Leu Arg Ala Gly Leu Leu Thr Ala Ala Leu Leu Leu Leu Gly 
1               5                   10                  15      


Thr Asn Ala Met Ala Ala Ala Pro Asp Ser Thr Pro Phe Tyr Trp Gln 
            20                  25                  30          


Val Pro Gly Ala Asp Glu Arg Thr Leu Gln Asp Ala Gly Phe Asp Val 
        35                  40                  45              


Glu His Gly Val Asp Gly Gly Val Gln Val Val Gly Asp Ala Arg Val 
    50                  55                  60                  


Ala Gly Arg Leu Thr Ala Leu Gly Tyr Gln Pro Lys Lys Phe Asp Thr 
65                  70                  75                  80  


Val Tyr Lys Pro Val Pro Pro Gly Arg Ser Gly Asp Ile Gly Val Gln 
                85                  90                  95      


Thr Phe Tyr Gly Gly Tyr His Thr Val Ala Glu His Glu Lys His Leu 
            100                 105                 110         


Thr Asp Val Ala Ala Ala Tyr Pro Ala Leu Thr Gln Val Phe Asp Ile 
        115                 120                 125             


Gly Asp Ser Trp Arg Lys Thr Arg Gly Leu Gly Gly His Asp Ile Lys 
    130                 135                 140                 


Ala Ile Cys Ile Thr Lys Lys Gln Ala Gly Asp Cys Ala Leu Ser Pro 
145                 150                 155                 160 


Thr Ser Pro Lys Pro Arg Phe Ala Met Ile Ala Gln Leu His Ala Arg 
                165                 170                 175     


Glu Leu Ala Thr Gly Glu Leu Ala Trp Arg Trp Ile Asp His Val Thr 
            180                 185                 190         


Arg Gly Tyr Gly Thr Asp Ala Glu Val Thr Ser Ile Leu Asp Thr Thr 
        195                 200                 205             


Glu Leu Trp Val Val Pro Ile Val Asn Pro Asp Gly Val Asp Ile Val 
    210                 215                 220                 


Ala Ser Gly Gly Ser Arg Pro Leu Met Gln Arg Lys Asn Ala Asn Asn 
225                 230                 235                 240 


Thr Gly Ala Ser Cys Ser Val Pro Ser Tyr Gly Val Asp Leu Asn Arg 
                245                 250                 255     


Asn Ser Thr Phe Lys Trp Gly Gly Ala Gly Thr Asn Arg Cys Gly Glu 
            260                 265                 270         


Thr Tyr Gln Gly Thr Ala Ala Gly Ser Glu Pro Glu Thr Arg Ala Leu 
        275                 280                 285             


Glu Ala Trp Phe Lys Gln Leu Phe Pro Asp Gln Arg Gly Pro Gly Asp 
    290                 295                 300                 


Thr Asp Pro Ala Pro Val Thr Thr Lys Gly Val Met Ile Thr Ile His 
305                 310                 315                 320 


Ser Tyr Gly Asn Leu Ile Met Pro Pro Trp Gly Trp Thr Trp Asn Ala 
                325                 330                 335     


Asn Pro Asn Ala Ala Gln Leu Ala Ala Leu Gly Lys Lys Met Ala Ala 
            340                 345                 350         


Phe Asn Gly Tyr Thr Val Val Ala Glu Gly Asp Thr Thr Gly Thr Thr 
        355                 360                 365             


Asp Asp Phe Thr Tyr Gly Thr Leu Gly Ile Ala Ser Tyr Thr Phe Glu 
    370                 375                 380                 


Ile Gly Ser Ser Ser Gly Ser Cys Gly Gly Phe Phe Pro Gln Tyr Ser 
385                 390                 395                 400 


Cys Val Asp Ser Leu Phe Trp Pro Arg Asn Lys Gly Ala Phe Leu Thr 
                405                 410                 415     


Ala Ala Lys Ala Ala Lys Ala Pro Tyr Ala Ser 
            420                 425         


<210>  25
<211>  466
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  25

Met Arg Ile Thr Asp Val Gln Arg Cys Glu Val Arg Pro Gly Arg Val 
1               5                   10                  15      


Val Glu Trp Val Leu Arg Pro Val Ala Ala Ala Thr Gly Ala Pro Asp 
            20                  25                  30          


Asp Ala Arg Pro Pro Ala Tyr Leu Gln Glu Ser His Val Arg Thr Ala 
        35                  40                  45              


Arg Ser Leu Arg Glu Asp Gly Leu Phe Val Pro Thr Trp Leu Gly Val 
    50                  55                  60                  


Ala Phe Asp Leu Pro Gly Ala Val Asp Leu Asp Ala Leu Glu Glu Ala 
65                  70                  75                  80  


Leu Arg Val Trp Thr Leu Arg His Glu Thr Leu Arg Ser Gly Phe Arg 
                85                  90                  95      


Trp Glu Asp Gly Glu Met Arg Arg Phe Thr Leu Asp Ala Asp Ala Val 
            100                 105                 110         


Ala Leu His Arg Glu Asp Val Gly Glu Phe Thr Asp Ala Asp Val Leu 
        115                 120                 125             


Val Gln His Leu Gln Asp Arg Phe Asp Val Ala Ala Asp Thr Leu Thr 
    130                 135                 140                 


Trp Pro Asn Phe Ile Tyr Ala Ala Val Ala Arg Glu Asp Ser Thr Ser 
145                 150                 155                 160 


Val Tyr Leu Ala Phe Asp His Ser Asn Val Asp Ala Tyr Ser Met Tyr 
                165                 170                 175     


Arg Val Pro Ala Glu Leu His Glu Leu Tyr Ala Ala Ala Leu Asp Gly 
            180                 185                 190         


Arg Thr Val Asp Ala Ala Pro Ile Ala Ser Tyr Val Asp Phe Cys Ala 
        195                 200                 205             


Thr Glu Arg Ala Asp Ala Asp Glu Val Asp Ala Asp His Pro Val Val 
    210                 215                 220                 


Asp Arg Trp Arg Arg Phe Val Ala Arg Cys Asp Gly Arg Met Pro Asn 
225                 230                 235                 240 


Phe Pro Phe Asp Leu Gly Leu Ala Pro Gly Gly Pro Leu Pro Thr Gln 
                245                 250                 255     


Lys Ser Leu His Glu Met Leu Val Asp Asp Ala Asp Ala Ala Ala Phe 
            260                 265                 270         


Glu Arg His Cys Arg Pro Tyr Gly Gly Ser Leu Val Gly Val Leu Ala 
        275                 280                 285             


Ala Thr Ala Leu Ile Met Arg Glu Met Thr Gly Asp Asp Val Tyr Arg 
    290                 295                 300                 


Thr Val Val Pro Phe His Thr Arg Ala Lys Ser Arg Trp Ser Asp Ser 
305                 310                 315                 320 


Val Gly Trp Tyr Val Gly Gly Val Pro Val Glu Leu Pro Val Ala Thr 
                325                 330                 335     


Ala Gly Gly Phe Asp Gly Leu Leu Arg Ala Ala Gln Ala Glu Leu Arg 
            340                 345                 350         


Ala Ser Arg Pro Ala Ser Arg Val Pro Val Ala Arg Val Leu Arg Leu 
        355                 360                 365             


Leu Gly Asp Asp Phe Arg Pro Thr Ser Pro Asp Leu Tyr Ser Ile Val 
    370                 375                 380                 


Ser Phe Met Asp Ala Arg Pro Thr Pro Gly Ser Glu Arg Trp Arg Asp 
385                 390                 395                 400 


Met Lys Ala Tyr Gly Leu Ile Arg Val Ser Tyr Gly Asp Gln Val Cys 
                405                 410                 415     


Val Trp Val Thr Arg Leu His Glu Gly Leu Gln Phe Ala Cys Arg Tyr 
            420                 425                 430         


Pro Asp Asn Asp Val Ala Tyr Lys Asn Ile Arg Leu Tyr Val Asp Arg 
        435                 440                 445             


Leu Arg Glu Val Ile Leu Ser Val Ala Arg Pro Ala Asp Ala Pro Ala 
    450                 455                 460                 


Ala Gly 
465     


<210>  26
<211>  200
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  26

Met Thr Ser Arg Phe Ala Gln Val Met Phe Thr Pro Asp Val Gln Leu 
1               5                   10                  15      


His Gln Glu Arg His Gly Ser Arg Asp Ala Tyr Ala Arg Met Ala Asp 
            20                  25                  30          


Ala Ala Pro Val Arg Asp Arg Ile Gly Pro Asp Glu Ala Ala Phe Ile 
        35                  40                  45              


Ala Glu Arg Asp Ser Phe Tyr Leu Ala Thr Val Gly Glu Thr Gly Trp 
    50                  55                  60                  


Pro Tyr Ile Gln His Arg Gly Gly Pro Pro Gly Phe Leu Arg Val Leu 
65                  70                  75                  80  


Asp Glu His Thr Leu Gly Phe Ala Asp Phe Arg Gly Asn Arg Gln Tyr 
                85                  90                  95      


Ile Thr Arg Gly Asn Leu Asp His Asp Asp Arg Val Ala Leu Phe Leu 
            100                 105                 110         


Met Asp Tyr Ala Asn Arg Thr Arg Leu Lys Leu Ile Gly His Ala Arg 
        115                 120                 125             


Ala Asp Asp Ser Pro Glu Val Val Glu Arg Leu Ala Leu Pro Asp Tyr 
    130                 135                 140                 


Arg Ala Lys Val Glu Arg Ala Val Leu Ile Glu Val Glu Ala Thr Ile 
145                 150                 155                 160 


Trp Asn Cys Arg Gln His Ile Pro Gln Leu Phe Pro Arg Asp Ala Val 
                165                 170                 175     


Glu Gln Ala Val Gly Ala Leu Arg Asp Arg Ile Thr Glu Leu Glu Gln 
            180                 185                 190         


Glu Asn Ala Arg Leu Arg Ala Arg 
        195                 200 


<210>  27
<211>  171
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  27

Met Ser Gly Arg Leu His Ala Pro Ala Ile Gly Thr Ala Arg Leu Asp 
1               5                   10                  15      


Leu Val Pro Leu Arg Val Asp His Ala Glu Glu Met Ala Val Val Leu 
            20                  25                  30          


Ala Asp Pro Ala Leu His Thr Phe Thr Gly Gly Thr Pro Asp Asp Pro 
        35                  40                  45              


Arg Ala Leu Arg Ser Arg Tyr Glu Arg Met Leu Ala Gly Ser Pro Asp 
    50                  55                  60                  


Pro Ala Val Ser Trp Leu Asn Trp Val Val Arg Leu Arg Glu Glu Ser 
65                  70                  75                  80  


Arg Leu Ala Gly Thr Val Gln Ala Thr Val Gly Pro Thr Asp Gln Gly 
                85                  90                  95      


Pro Val Ala Glu Val Ala Trp Val Val Gly Thr Pro Phe Gln Gly Arg 
            100                 105                 110         


Gly Ile Ala Arg Glu Ala Ala Arg Gly Leu Val Asp Trp Leu Gly Arg 
        115                 120                 125             


Gln Gly Val Arg Thr Val Val Ala His Val His Pro Asp His His Ala 
    130                 135                 140                 


Ser Ala Ala Val Ala Thr Ala Ala Gly Leu Ala Pro Thr Asp Glu Val 
145                 150                 155                 160 


His Asp Gly Glu Val Arg Trp Arg Leu Ser Arg 
                165                 170     


<210>  28
<211>  398
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  28

Met Ser Leu Asp Glu Arg Lys Leu Phe Ala Ala Arg Leu His Ala Val 
1               5                   10                  15      


Arg Cys Arg Pro Tyr Leu Ala Thr Ala Leu Phe Ala Leu His Val Val 
            20                  25                  30          


Glu Ser Arg Arg Val Pro Thr Met Ala Val Asp Arg His Trp Arg Cys 
        35                  40                  45              


Tyr Val Ser Pro Ala Phe Val Asp Arg Thr Pro Glu Glu Glu Leu Ala 
    50                  55                  60                  


Gly Val Trp Val His Glu Val Ser His Leu Leu Arg Asp His His Gly 
65                  70                  75                  80  


Arg Gly Asp Arg Phe Ala Ala Glu His Gly Leu Thr Gly Pro Gly Glu 
                85                  90                  95      


Arg Leu Arg Met Asn Ile Ala Ala Asp Cys Glu Ile Asn Asp Asp Val 
            100                 105                 110         


Phe Gly Asp Gly Leu Ala Arg Pro Glu Gly Ala Val Glu Pro Glu Leu 
        115                 120                 125             


Leu Gln Leu Arg Glu Gly Gln Leu Met Glu Asp Tyr Leu Arg Gln Phe 
    130                 135                 140                 


Arg Leu Gly Pro Tyr Thr Asp Ala Phe Thr Trp Leu Asp Cys Gly Ser 
145                 150                 155                 160 


Gly Ala Asp Gly Leu Glu Arg Glu Trp Asp Leu Gly Pro Asp Gly Ala 
                165                 170                 175     


His Gly Leu Ser Glu Gln Glu Arg Asp Ala Val Arg Phe Arg Val Ala 
            180                 185                 190         


Glu Ala Ile Thr Gly Arg Pro Gly Asp Val Pro Leu Gly Trp Arg Arg 
        195                 200                 205             


Trp Ala Glu Arg Ala Phe His Pro Pro Gln Pro Trp Arg Asp Leu Leu 
    210                 215                 220                 


Gly Ala Ala Val Arg Ser Ala Ala Ser Ala Ala Gly Ala Gly Asp Asp 
225                 230                 235                 240 


Tyr Thr Tyr Gly Arg Pro Ala Arg Arg Ser Thr Ala Leu Pro Gly Val 
                245                 250                 255     


Val Leu Pro Ser Leu Arg Arg Arg Pro Pro Arg Val Cys Val Val Val 
            260                 265                 270         


Asp Thr Ser Gly Ser Val Ser Asp Ala Glu Leu Gly Ser Ala Leu Leu 
        275                 280                 285             


Glu Ile Ala Ala Ile Ala Arg Ala Val Gly Gly Arg Arg Asp Leu Val 
    290                 295                 300                 


Ser Val Leu Ser Cys Asp Ala Ala Ala His Val Thr His Pro Leu Cys 
305                 310                 315                 320 


Arg Ala Glu Gly Ile Pro Leu Met Gly Gly Gly Gly Thr Asp Leu Arg 
                325                 330                 335     


Thr Gly Phe Thr Arg Ala Leu Arg Thr Arg Pro Asp Val Ile Val Ala 
            340                 345                 350         


Leu Thr Asp Gly Gln Thr Pro Trp Pro Thr Val Arg Pro Pro Cys Arg 
        355                 360                 365             


Thr Val Val Gly Leu Phe Arg Arg Pro Pro Lys Pro Gly Asp Tyr Arg 
    370                 375                 380                 


Pro Asp Pro Pro Pro Ala Trp Ala Arg Val Val Thr Val Gly 
385                 390                 395             


<210>  29
<211>  404
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  29

Met Pro Thr Ser Leu Ser Ala Arg Pro Leu Asp Val Ala Ala Asp Leu 
1               5                   10                  15      


Leu Ala Leu Leu Gly Arg Thr Thr Thr Glu Thr Arg Ser Asp Ala Gln 
            20                  25                  30          


Leu Glu Ala Leu Thr Leu Ala Val Ser Ala Asp Leu Pro Val Leu Leu 
        35                  40                  45              


Trp Gly Glu Pro Gly Ile Gly Lys Thr Ala Ala Leu Thr Gln Leu Ala 
    50                  55                  60                  


Asp Ala Leu Asp Leu Pro Leu Thr Thr Val Ile Ala Ser Val His Glu 
65                  70                  75                  80  


Pro Ser Asp Phe Ala Gly Leu Pro Val Val Gly Asp Asp Pro Ala Val 
                85                  90                  95      


Gln Gly Val Pro Met Ala Pro Pro Asp Trp Ala Val Arg Leu Val Arg 
            100                 105                 110         


Ala Gly Arg Gly Leu Leu Phe Leu Asp Glu Leu Ser Thr Ala Pro Pro 
        115                 120                 125             


Ala Val Gln Ala Ala Leu Leu Arg Val Val Leu Glu Arg Arg Ile Gly 
    130                 135                 140                 


Ala Leu Thr Leu Pro Pro Gly Val Arg Ile Val Ala Ala Ala Asn Pro 
145                 150                 155                 160 


Arg Ser Ser Ala Ala Asp Gly Trp Glu Leu Ser Pro Pro Leu Ala Asn 
                165                 170                 175     


Arg Phe Val His Leu Gln Trp Ala His Asp His Asp Val Val Val Arg 
            180                 185                 190         


Gly Leu Gly Gly Thr Trp Pro Arg Ala Glu Leu Pro Arg Leu Asp Pro 
        195                 200                 205             


Gly Arg Leu Pro Asp Ala Val Ala Tyr Ala Arg Arg Ala Val Cys Glu 
    210                 215                 220                 


Leu Leu Ala Ala Arg Pro Asn Leu Val His Gln Leu Pro Lys Asp Glu 
225                 230                 235                 240 


Thr Arg Arg Gly Gly Pro Trp Pro Ser Pro Arg Ser Trp Glu Met Ala 
                245                 250                 255     


Leu Arg Leu Ile Ala Phe Ala Thr Ala Ala Asp Val Ser Arg Asp Val 
            260                 265                 270         


Leu Ser Met Leu Val Arg Gly Thr Val Gly Asp Gly Pro Gly Leu Glu 
        275                 280                 285             


Leu Leu Ala Ser Leu Asp Arg Met Asp Leu Pro Asp Pro Glu Ser Leu 
    290                 295                 300                 


Leu Ala Asn Pro Ala Ala Ala Val Leu Pro Glu Arg Gly Asp Leu Arg 
305                 310                 315                 320 


Gln Ala Val Leu Asp Gly Val Val Glu Ala Val Arg Arg Arg Pro Glu 
                325                 330                 335     


Ala Ala Arg Trp Asp Ala Ala Trp Ala Leu Leu Val Arg Ala Leu Asp 
            340                 345                 350         


Thr Gly Ala Pro Asp Leu Val Val Val Pro Ala Ala Thr Leu Ala Ala 
        355                 360                 365             


Leu Arg Arg Asp Asp Trp Glu Val Pro Ala Ala Ile Glu Arg Leu Ser 
    370                 375                 380                 


Gly Ala Val Ser Val Ser Arg Leu Ala Asp Arg Thr Ala Ala Arg Val 
385                 390                 395                 400 


Gly Ala Gly Arg 
                


<210>  30
<211>  222
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  30

Met Ile Thr Val Arg Leu Asn Ala Gly Arg Trp Leu Ala Leu Ala Pro 
1               5                   10                  15      


Asp Glu Pro Thr Pro Val Leu Thr Ala Ala Pro Arg Arg Asp Pro Thr 
            20                  25                  30          


Arg Pro Val Leu Pro Asp Ala Ala Thr Arg Thr Pro Pro Asp Leu Asp 
        35                  40                  45              


Leu Leu Arg Ala Gly Leu Val Asp Ala Asp Arg Leu His Pro Leu Val 
    50                  55                  60                  


Ala Ser Ala Leu Val Pro Gly His Arg Arg Thr Thr Gly Ser Pro Asp 
65                  70                  75                  80  


Pro Ala Thr Gly Pro Arg Leu Val Glu Cys Arg Gly Ala Thr His Arg 
                85                  90                  95      


Ile Gly Val Val Asp Gly Val Leu Val Pro Leu Asp His Asp Pro Asp 
            100                 105                 110         


Glu Val Arg Arg Glu Glu Leu Leu Ala Glu Trp Gly Gly Pro Pro Leu 
        115                 120                 125             


Pro Cys Leu Arg Ala Ile Asp Asp Val His Arg Gln Pro Glu Ser Leu 
    130                 135                 140                 


Val Asp Val Arg Ala Arg Leu Asp His Gly Asp Thr Ala Gly Ala Val 
145                 150                 155                 160 


Ala Ala Val Glu Ala Leu Leu Gly Pro Glu Ala Leu Leu Arg Ala Gly 
                165                 170                 175     


Ala Leu Arg Asp Glu Leu Asp Ala Ala Val Arg Arg Arg Leu Ala His 
            180                 185                 190         


Gly Leu Tyr Arg Ala Gly Leu Ala Gly Gly Pro Ala Pro Ser Thr Lys 
        195                 200                 205             


Asp Gly Arg Arg Arg Val Arg Pro Arg His Ala Phe Ser Arg 
    210                 215                 220         


<210>  31
<211>  252
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  31

Met Leu Met His His Thr Thr Ala Asp Glu Asn Leu Arg Leu His Phe 
1               5                   10                  15      


Trp Thr Arg Val Arg Glu Phe Ala Val Pro Pro Ser Met Val Glu Thr 
            20                  25                  30          


Ala Thr Ala Arg Arg Ser Val Gly Asp Trp Ala Gly Ala Cys Ala Ala 
        35                  40                  45              


Ala Arg Phe Asp Val Asp Leu Asp Leu Arg Ala Val Gly Arg Thr His 
    50                  55                  60                  


Gly Arg Gln Leu Ala Ala Gln Val Arg Ala Asp Leu Arg His Leu Ala 
65                  70                  75                  80  


Pro Asp Leu Leu Arg Trp His Phe Pro Arg Ile Gly Pro Asp Gly Leu 
                85                  90                  95      


Leu Arg Pro Gly Leu Thr Val Ser Leu Ala Arg Tyr Ala Ala Gly Pro 
            100                 105                 110         


His Leu Val Ala Arg Thr Pro Pro Ala Trp Ala Ala Ala Gly Gln Arg 
        115                 120                 125             


Ile Ser Leu Ala Trp Trp Asp Pro Ala Glu Pro Arg Ala Gly Ala Gly 
    130                 135                 140                 


Thr His Pro His Pro Arg Pro Asp Arg Arg Phe Arg Leu Asp Leu His 
145                 150                 155                 160 


Arg His Leu Trp Asp Ala Arg Arg Ala Gly Glu Leu Arg Glu Arg Ser 
                165                 170                 175     


Ala Gly Gly Asp Pro Pro Pro Gly Phe Asp His Arg Ala Ala Arg Ser 
            180                 185                 190         


Arg Leu Ala Gly Arg Arg Val Ala Gly Ser Arg Gly Ala Arg Arg Val 
        195                 200                 205             


Arg Gly Pro Ser Gly Arg Arg Gln Pro Arg Asp Pro Pro Arg Arg Gly 
    210                 215                 220                 


Pro Ser Arg Gly Arg Val Ser Leu Ser Val Val Gly Cys Arg Arg Pro 
225                 230                 235                 240 


Cys Ser Ser Cys Ala Arg Thr Gly Ala Pro Thr Ala 
                245                 250         


<210>  32
<211>  248
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  32

Met Ala Gly Thr Asp Leu Tyr Asp Asp Ile Gly Thr Gly Tyr Ala Leu 
1               5                   10                  15      


Gly Arg Arg Thr Asp Pro Arg Trp Met Thr Ala Ile Leu Asp Ala Leu 
            20                  25                  30          


Gly Gly Ala Arg Thr Ile Ala Asn Val Gly Ala Gly Thr Gly Ser Tyr 
        35                  40                  45              


Glu Pro Asp Asp Arg Thr Val Val Ala Leu Glu Pro Ser Thr Glu Met 
    50                  55                  60                  


Ile Arg Gln Arg Pro Pro Glu Val Gly Pro Ala Val Arg Ala Val Ala 
65                  70                  75                  80  


Glu Ala Leu Pro Leu Arg Asp His Ala Val Asp Ala Ala Leu Ala Val 
                85                  90                  95      


Leu Thr Val His His Trp Thr Asp Trp Arg Ala Gly Leu Ala Glu Leu 
            100                 105                 110         


Arg Arg Ile Ala Pro Arg Arg Val Val Leu Ala Tyr Asp Thr Ser Leu 
        115                 120                 125             


His Thr Glu Phe Trp Phe Val Arg Glu Tyr Val Pro Glu Ile Ala Asp 
    130                 135                 140                 


Leu Glu Arg Thr Arg Pro Ser Ala Ala Asp Ile Ala Gly Glu Leu Gly 
145                 150                 155                 160 


Ala Asp Ser Val Thr Pro Leu Pro Leu Pro Trp Asp Phe Val Asp Gly 
                165                 170                 175     


Val Phe Pro Ala Tyr Trp Arg Arg Pro Asp Ala Tyr Leu Asp Pro Arg 
            180                 185                 190         


Val Arg Arg Ala Cys Ser Ala Leu Ala Gln Thr Asp Pro Ala Ala Val 
        195                 200                 205             


Asp Arg Gly Val Arg Arg Leu Arg Ala Asp Leu Asp Ser Gly Arg Trp 
    210                 215                 220                 


His Asp Asp His Arg Asp Leu Leu Asp Leu Asp Gln Trp Asp Ala Gly 
225                 230                 235                 240 


Phe Arg Leu Val Val Ser His Thr 
                245             


<210>  33
<211>  278
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  33

Met Gly Asn Gly Glu Arg Ile Gly Val Phe Tyr Asp Gly Thr Trp Phe 
1               5                   10                  15      


Ala Tyr Leu Ser Asp Tyr Phe Ala Ser Val His Pro Arg Ala Ala Arg 
            20                  25                  30          


Val Ser Leu Asp Gly Phe His Asp Ala Leu Arg Trp Tyr Val His Thr 
        35                  40                  45              


Val Thr His Gln Pro Leu Asp Glu Cys Val Val Ser Glu Ala His Tyr 
    50                  55                  60                  


Val Arg Gly Arg Ile Asp Thr Pro Ala Val Ala Phe Asp Ala Val Leu 
65                  70                  75                  80  


Ala Ala Ala Gly Val Val Arg His Asp Leu Pro Leu His Ala Gly Lys 
                85                  90                  95      


Glu Lys Gly Val Asp Val His Leu Ala Leu Glu Ala Trp Glu Arg Ala 
            100                 105                 110         


Thr Ser Val Pro Leu Arg Trp Val Val Leu Val Thr Gly Asp Ala Asp 
        115                 120                 125             


Phe Ala Pro Leu Ala Thr Arg Leu Lys Thr Arg Gly Val Arg Val Val 
    130                 135                 140                 


Val Pro Val Val Asp Gly Gly Val Val Ala Pro Ala Trp Met Pro Arg 
145                 150                 155                 160 


Thr Ala Ala Pro Leu Arg Ala Ala Ala Ser Ala Thr Pro Thr Phe Asp 
                165                 170                 175     


Asp Leu Phe Thr Pro Ala Glu Arg Asp Asp Tyr Pro Leu Arg Ala Pro 
            180                 185                 190         


Phe Val Arg Thr Ser Gly Gly Gly Ala Ser Val Ala Gly Glu Pro Arg 
        195                 200                 205             


Gly Arg Arg Lys Gly Thr Val Thr Gly Trp Lys Thr Gly Gln Pro His 
    210                 215                 220                 


Gly Phe Ile Thr Asp Thr Arg Gly Ala Ser Trp Phe Val Ser Arg Asp 
225                 230                 235                 240 


Asp Leu Pro Leu Gly Leu Val Ala Leu Pro Val Gly Thr Ser Val Ser 
                245                 250                 255     


Phe Ser Gly Pro Ser Thr Pro Pro Ala Gly Arg Lys Tyr Pro Arg Ala 
            260                 265                 270         


Tyr Ala Val Gln Thr Glu 
        275             


<210>  34
<211>  245
<212>  PRT
<213>  Saccharothrix mutabilis

<400>  34

Met Ser Lys Gln Pro Asp Ser Leu Arg Thr Thr Val Val Val Pro Thr 
1               5                   10                  15      


Tyr Asn Glu Arg Asp Asn Leu Pro Val Leu Val Asp Leu Leu Ala Asp 
            20                  25                  30          


Leu Gly Val Pro Gly Leu His Val Leu Val Val Asp Asp Asn Ser Pro 
        35                  40                  45              


Asp Gly Thr Gly Asp Leu Ala Asp Lys Leu Ala Leu Glu Gly Pro Leu 
    50                  55                  60                  


Pro Leu Ser Val Leu His Arg Thr Glu Lys Asp Gly Leu Gly Arg Ala 
65                  70                  75                  80  


Tyr Val Ala Gly Ile Leu Lys Ala Leu Asp Asp Gly Ala Asp Leu Val 
                85                  90                  95      


Val Gln Met Asp Ala Asp Leu Ser His Pro Ala Ser Ala Ile Pro Thr 
            100                 105                 110         


Met Ile Glu Val Leu Arg Thr Ser Asp Ala Ala Val Val Ile Gly Ser 
        115                 120                 125             


Arg Tyr Val Pro Gly Gly Ser Val Ser Gly Glu Trp Lys Trp His Arg 
    130                 135                 140                 


Lys Ala Leu Ser Leu Trp Ala Asn Val Tyr Val Asn Ala Ile Leu Arg 
145                 150                 155                 160 


Leu Arg Val Lys Asp Ala Thr Ala Gly Phe Lys Cys Trp Arg Ala Ala 
                165                 170                 175     


Thr Leu Arg Arg Ile Asp Val Gly Ser Ile Arg Ser Asn Gly Tyr Ala 
            180                 185                 190         


Phe Gln Val Glu Met Asn His Arg Val Val Lys Arg Gly Met Arg Ile 
        195                 200                 205             


Ala Glu Val Pro Ile Arg Phe Glu Glu Arg Ala Glu Gly Ala Ser Lys 
    210                 215                 220                 


Met Ser Phe Gly Val Gln Leu Glu Ser Ala Val Met Pro Trp Lys Leu 
225                 230                 235                 240 


Leu Phe Lys Lys Gly 
                245 


<210>  35
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct

<400>  35
cccaccttgt tgacgtggt                                                  19


<210>  36
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct

<400>  36
tcagcggtag gcggtcag                                                   18


<210>  37
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct

<400>  37
aagggccccc atatgccttc ggaaggtctg                                      30


<210>  38
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct

<400>  38
ggtgtgtgtt cgaactcaca ctaacgcgcc                                      30


<210>  39
<211>  65
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct

<400>  39
gtgcttgacc tctcccccgc gcagcgcagc ctgtgggtgt ctagaattcc ggggatccgt     60

cgacc                                                                 65


<210>  40
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct

<400>  40
ctattccgcg gtgatctcgt ccagcacggc caggaagtcg ctagctgtag gctggagctg     60

cttc                                                                  64


<210>  41
<211>  65
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct

<400>  41
gtgaccgcgc tgcaccgcct cgaccagctc gccggcgcgt ctagaattcc ggggatccgt     60

cgacc                                                                 65


<210>  42
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct

<400>  42
cacctcgggg tccggctgat caggcccgcc aacgcggtcg ctagctgtag gctggagctg     60

cttc                                                                  64


