

                                SEQUENCE LISTING

<110> SHEPARD, H. Michael 
	JIN, Pei

<120> METHODS OF TREATING INFLAMMATORY DISORDERS USING ISOFORMS OF RECEPTOR TYROSINE KINASES

<130> 602812001240

<140> Not yet assigned             
<141> herewith         

<160> 618

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 105
<212> DNA
<213> Homo sapiens

<400> 1
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccaga                 105

<210> 2
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg
        35  

<210> 3
<211> 2653
<212> DNA
<213> Homo sapiens

<400> 3
atggccctgt ccactgagca tcctcccgcc acacagaaac ccgcccagcc ggggccaccg 60
accccacccc ctgcctggaa acttaaggag gccggagctg tggggagctc agagctgaga 120
tcctacagga gtccagggct ggagagaaaa cctctgcgag gaaagggaag gagcaagccg 180
tgaatttaag ggacgctgtg aagcaatcat ggatgcaatg aagagagggc tctgctgtgt 240
gctgctgctg tgtggagcag tcttcgtttc gcccagccag gaaatccatg cccgattcag 300
aagaggagcc agatcttacc aagtgatctg cagagatgaa aaaacgcaga tgatatacca 360
gcaacatcag tcatggctgc gccctgtgct cagaagcaac cgggtggaat attgctggtg 420
caacagtggc agggcacagt gccactcagt gcctgtcaaa agttgcagcg agccaaggtg 480
tttcaacggg ggcacctgcc agcaggccct gtacttctca gatttcgtgt gccagtgccc 540
cgaaggattt gctgggaagt gctgtgaaat agataccagg gccacgtgct acgaggacca 600
gggcatcagc tacaggggca cgtggagcac agcggagagt ggcgccgagt gcaccaactg 660
gaacagcagc gcgttggccc agaagcccta cagcgggcgg aggccagacg ccatcaggct 720
gggcctgggg aaccacaact actgcagaaa cccagatcga gactcaaagc cctggtgcta 780
cgtctttaag gcggggaagt acagctcaga gttctgcagc acccctgcct gctctgaggg 840
aaacagtgac tgctactttg ggaatgggtc agcctaccgt ggcacgcaca gcctcaccga 900
gtcgggtgcc tcctgcctcc cgtggaattc catgatcctg ataggcaagg tttacacagc 960
acagaacccc agtgcccagg cactgggcct gggcaaacat aattactgcc ggaatcctga 1020
tggggatgcc aagccctggt gccacgtgct gaagaaccgc aggctgacgt gggagtactg 1080
tgatgtgccc tcctgctcca cctgcggcct gagacagtac agccagcctc agtttcgcat 1140
caaaggaggg ctcttcgccg acatcgcctc ccacccctgg caggctgcca tctttgccaa 1200
gcacaggagg tcgcccggag agcggttcct gtgcgggggc atactcatca gctcctgctg 1260
gattctctct gccgcccact gcttccagga gaggtttccg ccccaccacc tgacggtgat 1320
cttgggcaga acataccggg tggtccctgg cgaggaggag cagaaatttg aagtcgaaaa 1380
atacattgtc cataaggaat tcgatgatga cacttacgac aatgacattg cgctgctgca 1440
gctgaaatcg gattcgtccc gctgtgccca ggagagcagc gtggtccgca ctgtgtgcct 1500
tcccccggcg gacctgcagc tgccggactg gacggagtgt gagctctccg gctacggcaa 1560
gcatgaggcc ttgtctcctt tctattcgga gcggctgaag gaggctcatg tcagactgta 1620
cccatccagc cgctgcacat cacaacattt acttaacaga acagtcaccg acaacatgct 1680
gtgtgctgga gacactcgga gcggcgggcc ccaggcaaac ttgcacgacg cctgccaggg 1740
cgattcggga ggccccctgg tgtgtctgaa cgatggccgc atgactttgg tgggcatcat 1800
cagctggggc ctgggctgtg gacagaagga tgtcccgggt gtgtacacca aggttaccaa 1860
ctacctagac tggattcgtg acaacatgcg accgtgacca ggaacacccg actcctcaaa 1920
agcaaatgag atcccgcctc ttcttcttca gaagacactg caaaggcgca gtgcttctct 1980
acagacttct ccagacccac cacaccgcag aagcgggacg agaccctaca ggagagggaa 2040
gagtgcattt tcccagatac ttcccatttt ggaagttttc aggacttggt ctgatttcag 2100
gatactctgt cagatgggaa gacatgaatg cacactagcc tctccaggaa tgcctcctcc 2160
ctgggcagaa agtggccatg ccaccctgtt ttcagctaaa gcccaacctc ctgacctgtc 2220
accgtgagca gctttggaaa caggaccaca aaaatgaaag catgtctcaa tagtaaaaga 2280
taacaagatc tttcaggaaa gacggattgc attagaaata gacagtatat ttatagtcac 2340
aagagcccag cagggcctca aagttggggc aggctggctg gcccgtcatg ttcctcaaaa 2400
gcacccttga cgtcaagtct ccttcccctt tccccactcc ctggctctca gaaggtattc 2460
cttttgtgta cagtgtgtaa agtgtaaatc ctttttcttt ataaacttta gagtagcatg 2520
agagaattgt atcatttgaa caactaggct tcagcatatt tatagcaatc catgttagtt 2580
tttactttct gttgccacaa ccctgtttta tactgtactt aataaattca gatatatttt 2640
tcacagtttt tcc                                                    2653

<210> 4
<211> 562
<212> PRT
<213> Homo sapiens

<400> 4
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Ser Tyr Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met
        35                  40                  45              
Ile Tyr Gln Gln His Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn
    50                  55                  60                  
Arg Val Glu Tyr Cys Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser
65                  70                  75                  80  
Val Pro Val Lys Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr
                85                  90                  95      
Cys Gln Gln Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Glu
            100                 105                 110         
Gly Phe Ala Gly Lys Cys Cys Glu Ile Asp Thr Arg Ala Thr Cys Tyr
        115                 120                 125             
Glu Asp Gln Gly Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser
    130                 135                 140                 
Gly Ala Glu Cys Thr Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro
145                 150                 155                 160 
Tyr Ser Gly Arg Arg Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His
                165                 170                 175     
Asn Tyr Cys Arg Asn Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val
            180                 185                 190         
Phe Lys Ala Gly Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys
        195                 200                 205             
Ser Glu Gly Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg
    210                 215                 220                 
Gly Thr His Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn
225                 230                 235                 240 
Ser Met Ile Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala
                245                 250                 255     
Gln Ala Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly
            260                 265                 270         
Asp Ala Lys Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr Trp
        275                 280                 285             
Glu Tyr Cys Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr
    290                 295                 300                 
Ser Gln Pro Gln Phe Arg Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala
305                 310                 315                 320 
Ser His Pro Trp Gln Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro
                325                 330                 335     
Gly Glu Arg Phe Leu Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile
            340                 345                 350         
Leu Ser Ala Ala His Cys Phe Gln Glu Arg Phe Pro Pro His His Leu
        355                 360                 365             
Thr Val Ile Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu
    370                 375                 380                 
Gln Lys Phe Glu Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp
385                 390                 395                 400 
Asp Thr Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser
                405                 410                 415     
Ser Arg Cys Ala Gln Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro
            420                 425                 430         
Pro Ala Asp Leu Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly
        435                 440                 445             
Tyr Gly Lys His Glu Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys
    450                 455                 460                 
Glu Ala His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His
465                 470                 475                 480 
Leu Leu Asn Arg Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr
                485                 490                 495     
Arg Ser Gly Gly Pro Gln Ala Asn Leu His Asp Ala Cys Gln Gly Asp
            500                 505                 510         
Ser Gly Gly Pro Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val
        515                 520                 525             
Gly Ile Ile Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly
    530                 535                 540                 
Val Tyr Thr Lys Val Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met
545                 550                 555                 560 
Arg Pro
        


<210> 5
<211> 105
<212> DNA
<213> Homo sapiens

<220> 
<221> allele         
<222> 101
<223> n = C or A

<400> 5
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ncaga                 105

<210> 6
<211> 35
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 34
<223> Xaa= A or D

<400> 6
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Xaa Arg
        35  


<210> 7
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer tPA_F

<400> 7
ctctgcgagg aaagggaagg a                                           21

<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer tPA_R

<400> 8
cgtgcccctg tagctgatgc c                                           21

<210> 9
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer tPApre/pro_F1

<400> 9
attagctagc caccatggat gcaatgaaga gaggg                            35

<210> 10
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer tPApre/pro_R1

<400> 10
attactcgag cagatcctct tctgagatga gtttttgttc tggctcctct tcgaatcg   58

<210> 11
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer tPApre/pro_F2

<400> 11
attagaattc caccatggat gcaatgaaga gaggg                            35

<210> 12
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer tPApre/pro_R2

<400> 12
attatctaga tctggctcct cttctgaatc g                                31

<210> 13
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer VEGFR1IFP_F

<400> 13
aaggctcgag tcaaaattaa aagatcctga ac                               32

<210> 14
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer VEGFR1IFP_R

<400> 14
aaggaaaaaa gcggccgctc acggaaggaa atggaag                          37

<210> 15
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer METIFP_F

<400> 15
aaggctcgag tgtaaagagg cactagcaaa g                                31

<210> 16
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer METIFP_R

<400> 16
aaggaaaaaa gcggccgctc acggaaggaa atggaag                          37

<210> 17
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer FGFR2IFP_F

<400> 17
aaggctcgag ccctccttca gtttagttga                                  30

<210> 18
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer FGFR2IFP_R

<400> 18
aaggaaaaaa gcggccgctt atgcaaggat aaaagggg                         38

<210> 19
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer DCPTIFP_F

<400> 19
aatttctaga caagtgtgca ccggcacaga c                                31

<210> 20
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer DCPTIFP_R

<400> 20
aaggaaaagc ggccgctcag ccttcatacc gggac                            35

<210> 21
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer FGFR2IFP_F2

<400> 21
aattctcgag ccctccttca gtttagttga                                  30

<210> 22
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer FGFR2IFP_R2

<400> 22
aattgaattc ttatgcaagg ataaaagggg c                                31

<210> 23
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer FGFR4IFP_F

<400> 23
aattctcgag gaggaagtgg agcttgagcc                                  30

<210> 24
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer FGFR4IFP_R

<400> 24
aattgaattc ctaactcagt ccctcccag                                   29

<210> 25
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer RAGEIFP_F

<400> 25
aattctcgag caaaacatca cagcccgga                                   29

<210> 26
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer RAGEIFP_R

<400> 26
aattgaattc ctaagggtca gacttccaga                                  30

<210> 27
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer TEKIFP_F

<400> 27
aattctcgag gtggaaggtg ccatggact                                   29

<210> 28
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer TEKIFP_R

<400> 28
aattgaattc ttaccactgt ttacttctat atga                             34

<210> 29
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer RONIFP_F

<400> 29
aattctcgag gactggcagt gcccgcg                                     27

<210> 30
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer RONIFP_R

<400> 30
aattgaattc tcatgaggac cagccagtag                                  30

<210> 31
<211> 1686
<212> DNA
<213> Artificial Sequence

<220> 
<223> tPA-myc-VEGFR-1

<400> 31
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga gtcaaaatta aaagatcctg aactgagttt aaaaggcacc 180
cagcacatca tgcaagcagg ccagacactg catctccaat gcagggggga agcagcccat 240
aaatggtctt tgcctgaaat ggtgagtaag gaaagcgaaa ggctgagcat aactaaatct 300
gcctgtggaa gaaatggcaa acaattctgc agtactttaa ccttgaacac agctcaagca 360
aaccacactg gcttctacag ctgcaaatat ctagctgtac ctacttcaaa gaagaaggaa 420
acagaatctg caatctatat atttattagt gatacaggta gacctttcgt agagatgtac 480
agtgaaatcc ccgaaattat acacatgact gaaggaaggg agctcgtcat tccctgccgg 540
gttacgtcac ctaacatcac tgttacttta aaaaagtttc cacttgacac tttgatccct 600
gatggaaaac gcataatctg ggacagtaga aagggcttca tcatatcaaa tgcaacgtac 660
aaagaaatag ggcttctgac ctgtgaagca acagtcaatg ggcatttgta taagacaaac 720
tatctcacac atcgacaaac caatacaatc atagatgtcc aaataagcac accacgccca 780
gtcaaattac ttagaggcca tactcttgtc ctcaattgta ctgctaccac tcccttgaac 840
acgagagttc aaatgacctg gagttaccct gatgaaaaaa ataagagagc ttccgtaagg 900
cgacgaattg accaaagcaa ttcccatgcc aacatattct acagtgttct tactattgac 960
aaaatgcaga acaaagacaa aggactttat acttgtcgtg taaggagtgg accatcattc 1020
aaatctgtta acacctcagt gcatatatat gataaagcat tcatcactgt gaaacatcga 1080
aaacagcagg tgcttgaaac cgtagctggc aagcggtctt accggctctc tatgaaagtg 1140
aaggcatttc cctcgccgga agttgtatgg ttaaaagatg ggttacctgc gactgagaaa 1200
tctgctcgct atttgactcg tggctactcg ttaattatca aggacgtaac tgaagaggat 1260
gcagggaatt atacaatctt gctgagcata aaacagtcaa atgtgtttaa aaacctcact 1320
gccactctaa ttgtcaatgt gaaaccccag atttacgaaa aggccgtgtc atcgtttcca 1380
gacccggctc tctacccact gggcagcaga caaatcctga cttgtaccgc atatggtatc 1440
cctcaaccta caatcaagtg gttctggcac ccctgtaacc ataatcattc cgaagcaagg 1500
tgtgactttt gttccaataa tgaagagtcc tttatcctgg atgctgacag caacatggga 1560
aacagaattg agagcatcac tcagcgcatg gcaataatag aaggaaagaa taagcttcca 1620
ccagctaaca gttctttcat gttgccacct acaagcttct cttccaacta cttccatttc 1680
cttccg                                                            1686

<210> 32
<211> 562
<212> PRT
<213> Artificial Sequence

<220> 
<223> tPA-myc-VEGFR-1

<400> 32
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Ser
        35                  40                  45              
Lys Leu Lys Asp Pro Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met
    50                  55                  60                  
Gln Ala Gly Gln Thr Leu His Leu Gln Cys Arg Gly Glu Ala Ala His
65                  70                  75                  80  
Lys Trp Ser Leu Pro Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser
                85                  90                  95      
Ile Thr Lys Ser Ala Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr
            100                 105                 110         
Leu Thr Leu Asn Thr Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys
        115                 120                 125             
Lys Tyr Leu Ala Val Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala
    130                 135                 140                 
Ile Tyr Ile Phe Ile Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr
145                 150                 155                 160 
Ser Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val
                165                 170                 175     
Ile Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys
            180                 185                 190         
Phe Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp
        195                 200                 205             
Ser Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly
    210                 215                 220                 
Leu Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn
225                 230                 235                 240 
Tyr Leu Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser
                245                 250                 255     
Thr Pro Arg Pro Val Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn
            260                 265                 270         
Cys Thr Ala Thr Thr Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser
        275                 280                 285             
Tyr Pro Asp Glu Lys Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp
    290                 295                 300                 
Gln Ser Asn Ser His Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp
305                 310                 315                 320 
Lys Met Gln Asn Lys Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser
                325                 330                 335     
Gly Pro Ser Phe Lys Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys
            340                 345                 350         
Ala Phe Ile Thr Val Lys His Arg Lys Gln Gln Val Leu Glu Thr Val
        355                 360                 365             
Ala Gly Lys Arg Ser Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro
    370                 375                 380                 
Ser Pro Glu Val Val Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys
385                 390                 395                 400 
Ser Ala Arg Tyr Leu Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val
                405                 410                 415     
Thr Glu Glu Asp Ala Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln
            420                 425                 430         
Ser Asn Val Phe Lys Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys
        435                 440                 445             
Pro Gln Ile Tyr Glu Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu
    450                 455                 460                 
Tyr Pro Leu Gly Ser Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile
465                 470                 475                 480 
Pro Gln Pro Thr Ile Lys Trp Phe Trp His Pro Cys Asn His Asn His
                485                 490                 495     
Ser Glu Ala Arg Cys Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile
            500                 505                 510         
Leu Asp Ala Asp Ser Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln
        515                 520                 525             
Arg Met Ala Ile Ile Glu Gly Lys Asn Lys Leu Pro Pro Ala Asn Ser
    530                 535                 540                 
Ser Phe Met Leu Pro Pro Thr Ser Phe Ser Ser Asn Tyr Phe His Phe
545                 550                 555                 560 
Leu Pro
        


<210> 33
<211> 2697
<212> DNA
<213> Artificial Sequence

<220> 
<223> tPA-myc-MET

<400> 33
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga gtgtaaagag gcactagcaa agtccgagat gaatgtgaat 180
atgaagtatc agcttcccaa cttcaccgcg gaaacaccca tccagaatgt cattctacat 240
gagcatcaca ttttccttgg tgccactaac tacatttatg ttttaaatga ggaagacctt 300
cagaaggttg ctgagtacaa gactgggcct gtgctggaac acccagattg tttcccatgt 360
caggactgca gcagcaaagc caatttatca ggaggtgttt ggaaagataa catcaacatg 420
gctctagttg tcgacaccta ctatgatgat caactcatta gctgtggcag cgtcaacaga 480
gggacctgcc agcgacatgt ctttccccgc aatcatactg ctgacataca gtcggaggtt 540
cactgcatat tctccccaca gatagaagag cccagccagt gtcctgactg tgtggtgagc 600
gccctgggag ccaaagtcct ttcatctgta aaggaccggt tcaccaactt ctttgtaggc 660
aataccataa attcttctta tttcccagat catccattgc attcgatatc agtgagaagg 720
ctaaaggaaa cgaaagatgg ttttatgttt ttgacggacc agtcctacat tgatgtttta 780
cctgagttca gagattctta ccccattaag tatgtccatg cctttgaaag caacaatttt 840
atttacttct tgacggtcca aagggaaact ctagatgctc agacttttca cacaagaata 900
atcaggttct gttccataaa ctctggattg cattcctaca tggaaatgcc tctggagtgt 960
attctcacag aaaagagaaa aaagagatcc acaaagaagg aagtgtttaa tatacttcag 1020
gctgcgtatg tcagcaagcc tggggcccag cttgctagac aaataggagc cagcccgaat 1080
gatgacattc ttttcggagt gttcgcacaa agcaagccag attctgccga accaatggat 1140
cgatctgcca tgtgtgcatt ccctatcaaa tatgtcaacg acttcttcaa caagatcgtc 1200
aacaaaaaca atgtgagatg tctccagcat ttttacggac ccaatcatga gcactgcttt 1260
aataggacac ttctgagaaa ttcatcaggc tgtgaagcgc gccgtgatga atatcgaaca 1320
gagttcacca cagctttgca gcgcgttgac ttattcatgg gtcaattcag cgaagtcctc 1380
ttaacatcta tatccacctt cattaaagga gacctcacca tagctaatct tgggacatca 1440
gagggtcgct tcatgcaggt tgtggtttct cgatcaggac catcaacccc tcatgtgaat 1500
tttctcctgg actcccatcc agtgtctcca gaagtgattg tggagcatac attaaaccaa 1560
aatggctaca cactggttat cactgggaag aagatcacga agatcccatt gaatggcttg 1620
ggctgcagac atttccagtc ctgcagtcaa tgcctctctg ccccaccctt tgttcagtgt 1680
ggctggtgcc acgacaaatg tgtgcgatcg gaggaatgcc tgagcgggac atggactcaa 1740
cagatctgtc tgcctgcaat ctacaaggtt ttcccaaata gtgcacccct tgaaggaggg 1800
acaaggctga ccatatgtgg ctgggacttt ggatttcgga ggaataataa atttgattta 1860
aagaaaacta gagttctcct tggaaatgag agctgcacct tgactttaag tgagagcacg 1920
atgaatacat tgaaatgcac agttggtcct gccatgaata agcatttcaa tatgtccata 1980
attatttcaa atggccacgg gacaacacaa tacagtacat tctcctatgt ggatcctgta 2040
ataacaagta tttcgccgaa atacggtcct atggctggtg gcactttact tactttaact 2100
ggaaattacc taaacagtgg gaattctaga cacatttcaa ttggtggaaa aacatgtact 2160
ttaaaaagtg tgtcaaacag tattcttgaa tgttataccc cagcccaaac catttcaact 2220
gagtttgctg ttaaattgaa aattgactta gccaaccgag agacaagcat cttcagttac 2280
cgtgaagatc ccattgtcta tgaaattcat ccaaccaaat cttttattag tggtgggagc 2340
acaataacag gtgttgggaa aaacctgaat tcagttagtg tcccgagaat ggtcataaat 2400
gtgcatgaag cgggaaggaa ctttacagtg gcatgtcaac atcgctctaa ttcagagata 2460
atctgttgta ccactccttc cctgcaacag ctgaatctgc aactccccct gaaaaccaaa 2520
gcctttttca tgttagatgg gatcctttcc aaatactttg atctcattta tgtacataat 2580
cctgtgttta agccttttga aaagccagtg atgatctcaa tgggcaatga aaatgtactg 2640
gaaattaagg taagaaatgc tttaaacact gtcttaaatc atcagctcaa acttaat    2697

<210> 34
<211> 899
<212> PRT
<213> Artificial Sequence

<220> 
<223> tPA-myc-MET

<400> 34
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Cys
        35                  40                  45              
Lys Glu Ala Leu Ala Lys Ser Glu Met Asn Val Asn Met Lys Tyr Gln
    50                  55                  60                  
Leu Pro Asn Phe Thr Ala Glu Thr Pro Ile Gln Asn Val Ile Leu His
65                  70                  75                  80  
Glu His His Ile Phe Leu Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn
                85                  90                  95      
Glu Glu Asp Leu Gln Lys Val Ala Glu Tyr Lys Thr Gly Pro Val Leu
            100                 105                 110         
Glu His Pro Asp Cys Phe Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn
        115                 120                 125             
Leu Ser Gly Gly Val Trp Lys Asp Asn Ile Asn Met Ala Leu Val Val
    130                 135                 140                 
Asp Thr Tyr Tyr Asp Asp Gln Leu Ile Ser Cys Gly Ser Val Asn Arg
145                 150                 155                 160 
Gly Thr Cys Gln Arg His Val Phe Pro Arg Asn His Thr Ala Asp Ile
                165                 170                 175     
Gln Ser Glu Val His Cys Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser
            180                 185                 190         
Gln Cys Pro Asp Cys Val Val Ser Ala Leu Gly Ala Lys Val Leu Ser
        195                 200                 205             
Ser Val Lys Asp Arg Phe Thr Asn Phe Phe Val Gly Asn Thr Ile Asn
    210                 215                 220                 
Ser Ser Tyr Phe Pro Asp His Pro Leu His Ser Ile Ser Val Arg Arg
225                 230                 235                 240 
Leu Lys Glu Thr Lys Asp Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr
                245                 250                 255     
Ile Asp Val Leu Pro Glu Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val
            260                 265                 270         
His Ala Phe Glu Ser Asn Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg
        275                 280                 285             
Glu Thr Leu Asp Ala Gln Thr Phe His Thr Arg Ile Ile Arg Phe Cys
    290                 295                 300                 
Ser Ile Asn Ser Gly Leu His Ser Tyr Met Glu Met Pro Leu Glu Cys
305                 310                 315                 320 
Ile Leu Thr Glu Lys Arg Lys Lys Arg Ser Thr Lys Lys Glu Val Phe
                325                 330                 335     
Asn Ile Leu Gln Ala Ala Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala
            340                 345                 350         
Arg Gln Ile Gly Ala Ser Pro Asn Asp Asp Ile Leu Phe Gly Val Phe
        355                 360                 365             
Ala Gln Ser Lys Pro Asp Ser Ala Glu Pro Met Asp Arg Ser Ala Met
    370                 375                 380                 
Cys Ala Phe Pro Ile Lys Tyr Val Asn Asp Phe Phe Asn Lys Ile Val
385                 390                 395                 400 
Asn Lys Asn Asn Val Arg Cys Leu Gln His Phe Tyr Gly Pro Asn His
                405                 410                 415     
Glu His Cys Phe Asn Arg Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu
            420                 425                 430         
Ala Arg Arg Asp Glu Tyr Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg
        435                 440                 445             
Val Asp Leu Phe Met Gly Gln Phe Ser Glu Val Leu Leu Thr Ser Ile
    450                 455                 460                 
Ser Thr Phe Ile Lys Gly Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser
465                 470                 475                 480 
Glu Gly Arg Phe Met Gln Val Val Val Ser Arg Ser Gly Pro Ser Thr
                485                 490                 495     
Pro His Val Asn Phe Leu Leu Asp Ser His Pro Val Ser Pro Glu Val
            500                 505                 510         
Ile Val Glu His Thr Leu Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr
        515                 520                 525             
Gly Lys Lys Ile Thr Lys Ile Pro Leu Asn Gly Leu Gly Cys Arg His
    530                 535                 540                 
Phe Gln Ser Cys Ser Gln Cys Leu Ser Ala Pro Pro Phe Val Gln Cys
545                 550                 555                 560 
Gly Trp Cys His Asp Lys Cys Val Arg Ser Glu Glu Cys Leu Ser Gly
                565                 570                 575     
Thr Trp Thr Gln Gln Ile Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro
            580                 585                 590         
Asn Ser Ala Pro Leu Glu Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp
        595                 600                 605             
Asp Phe Gly Phe Arg Arg Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg
    610                 615                 620                 
Val Leu Leu Gly Asn Glu Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr
625                 630                 635                 640 
Met Asn Thr Leu Lys Cys Thr Val Gly Pro Ala Met Asn Lys His Phe
                645                 650                 655     
Asn Met Ser Ile Ile Ile Ser Asn Gly His Gly Thr Thr Gln Tyr Ser
            660                 665                 670         
Thr Phe Ser Tyr Val Asp Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr
        675                 680                 685             
Gly Pro Met Ala Gly Gly Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu
    690                 695                 700                 
Asn Ser Gly Asn Ser Arg His Ile Ser Ile Gly Gly Lys Thr Cys Thr
705                 710                 715                 720 
Leu Lys Ser Val Ser Asn Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln
                725                 730                 735     
Thr Ile Ser Thr Glu Phe Ala Val Lys Leu Lys Ile Asp Leu Ala Asn
            740                 745                 750         
Arg Glu Thr Ser Ile Phe Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu
        755                 760                 765             
Ile His Pro Thr Lys Ser Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly
    770                 775                 780                 
Val Gly Lys Asn Leu Asn Ser Val Ser Val Pro Arg Met Val Ile Asn
785                 790                 795                 800 
Val His Glu Ala Gly Arg Asn Phe Thr Val Ala Cys Gln His Arg Ser
                805                 810                 815     
Asn Ser Glu Ile Ile Cys Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn
            820                 825                 830         
Leu Gln Leu Pro Leu Lys Thr Lys Ala Phe Phe Met Leu Asp Gly Ile
        835                 840                 845             
Leu Ser Lys Tyr Phe Asp Leu Ile Tyr Val His Asn Pro Val Phe Lys
    850                 855                 860                 
Pro Phe Glu Lys Pro Val Met Ile Ser Met Gly Asn Glu Asn Val Leu
865                 870                 875                 880 
Glu Ile Lys Val Arg Asn Ala Leu Asn Thr Val Leu Asn His Gln Leu
                885                 890                 895     
Lys Leu Asn
            


<210> 35
<211> 1263
<212> DNA
<213> Artificial Sequence

<220> 
<223> tPA-myc-FGFR-2

<400> 35
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga gccctccttc agtttagttg aggataccac attagagcca 180
gaagagccac caaccaaata ccaaatctct caaccagaag tgtacgtggc tgcgccaggg 240
gagtcgctag aggtgcgctg cctgttgaaa gatgccgccg tgatcagttg gactaaggat 300
ggggtgcact tggggcccaa caataggaca gtgcttattg gggagtactt gcagataaag 360
ggcgccacgc ctagagactc cggcctctat gcttgtactg ccagtaggac tgtagacagt 420
gaaacttggt acttcatggt gaatgtcaca gatgccatct catccggaga tgatgaggat 480
gacaccgatg gtgcggaaga ttttgtcagt gagaacagta acaacaagag agcaccatac 540
tggaccaaca cagaaaagac ggaaaagcgg ctccatgctg tgcctgcggc caacactgtc 600
aagtttcgct gcccagccgg ggggaaccca atgccaacca tgcggtggct gaaaaacggg 660
aaggagttta agcaggagca tcgcattgga ggctacaagg tacgaaacca gcactggagc 720
ctcattatgg aaagtgtggt cccatctgac aagggaaatt atacctgtgt ggtggagaat 780
gaatacgggt ccatcaatca cacgtaccac ctggatgttg tggagcgatc gcctcaccgg 840
cccatcctcc aagccggact gccggcaaat gcctccacag tggtcggagg agacgtagag 900
tttgtctgca aggtttacag tgatgcccag ccccacatcc agtggatcaa gcacgtggaa 960
aagaacggca gtaaatacgg gcccgacggg ctgccctacc tcaaggttct caaggccgcc 1020
ggtgttaaca ccacggacaa agagattgag gttctctata ttcggaatgt aacttttgag 1080
gacgctgggg aatatacgtg cttggcgggt aattctattg ggatatcctt tcactctgca 1140
tggttgacag ttctgccagg tatatactgt tctttctctc tgggtttttt tcccttttct 1200
tggttgactg ctataaaatt aacacagctt ctgttatcag aaatggcccc ttttatcctt 1260
gca                                                               1263

<210> 36
<211> 421
<212> PRT
<213> Artificial Sequence

<220> 
<223> tPA-myc-FGFR-2

<400> 36
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Pro
        35                  40                  45              
Ser Phe Ser Leu Val Glu Asp Thr Thr Leu Glu Pro Glu Glu Pro Pro
    50                  55                  60                  
Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val Tyr Val Ala Ala Pro Gly
65                  70                  75                  80  
Glu Ser Leu Glu Val Arg Cys Leu Leu Lys Asp Ala Ala Val Ile Ser
                85                  90                  95      
Trp Thr Lys Asp Gly Val His Leu Gly Pro Asn Asn Arg Thr Val Leu
            100                 105                 110         
Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala Thr Pro Arg Asp Ser Gly
        115                 120                 125             
Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val Asp Ser Glu Thr Trp Tyr
    130                 135                 140                 
Phe Met Val Asn Val Thr Asp Ala Ile Ser Ser Gly Asp Asp Glu Asp
145                 150                 155                 160 
Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn Asn Lys
                165                 170                 175     
Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Thr Glu Lys Arg Leu His
            180                 185                 190         
Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala Gly Gly
        195                 200                 205             
Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys
    210                 215                 220                 
Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His Trp Ser
225                 230                 235                 240 
Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys
                245                 250                 255     
Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His Leu Asp
            260                 265                 270         
Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro
        275                 280                 285             
Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val Cys Lys
    290                 295                 300                 
Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His Val Glu
305                 310                 315                 320 
Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val
                325                 330                 335     
Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys Glu Ile Glu Val Leu
            340                 345                 350         
Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu
        355                 360                 365             
Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu Thr Val
    370                 375                 380                 
Leu Pro Gly Ile Tyr Cys Ser Phe Ser Leu Gly Phe Phe Pro Phe Ser
385                 390                 395                 400 
Trp Leu Thr Ala Ile Lys Leu Thr Gln Leu Leu Leu Ser Glu Met Ala
                405                 410                 415     
Pro Phe Ile Leu Ala
            420     


<210> 37
<211> 1323
<212> DNA
<213> Artificial Sequence

<220> 
<223> tPA_DCPT

<400> 37
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagatctag acaccaccat 120
catcaccatc accatcaagt gtgcaccggc acagacatga agctgcggct ccctgccagt 180
cccgagaccc acctggacat gctccgccac ctctaccagg gctgccaggt ggtgcaggga 240
aacctggaac tcacctacct gcccaccaat gccagcctgt ccttcctgca ggatatccag 300
gaggtgcagg gctacgtgct catcgctcac aaccaagtga ggcaggtccc actgcagagg 360
ctgcggattg tgcgaggcac ccagctcttt gaggacaact atgccctggc cgtgctagac 420
aatggagacc cgctgaacaa taccacccct gtcacagggg cctccccagg aggcctgcgg 480
gagctgcagc ttcgaagcct cacagagatc ttgaaaggag gggtcttgat ccagcggaac 540
ccccagctct gctaccagga cacgattttg tggaaggaca tcttccacaa gaacaaccag 600
ctggctctca cactgataga caccaaccgc tctcgggcct gccacccctg ttctccgatg 660
tgtaagggct cccgctgctg gggagagagt tctgaggatt gtcagagcct gacgcgcact 720
gtctgtgccg gtggctgtgc ccgctgcaag gggccactgc ccactgactg ctgccatgag 780
cagtgtgctg ccggctgcac gggccccaag cactctgact gcctggcctg cctccacttc 840
aaccacagtg gcatctgtga gctgcactgc ccagccctgg tcacctacaa cacagacacg 900
tttgagtcca tgcccaatcc cgagggccgg tatacattcg gcgccagctg tgtgactgcc 960
tgtccctaca actacctttc tacggacgtg ggatcctgca ccctcgtctg ccccctgcac 1020
aaccaagagg tgacagcaga ggatggaaca cagcggtgtg agaagtgcag caagccctgt 1080
gcccgaggta cccactcact gcccccgagg ccagctgcag ttcctgtccc tctgcgcatg 1140
cagcctggcc cagcccaccc tgtcctatcc ttcctcagac cctcttggga cctagtctct 1200
gccttctact ctctacccct ggcccccctc agccctacaa gtgtccctat atcccctgtc 1260
agtgtgggga ggggcccgga ccctgatgct catgtggctg ttgacctgtc ccggtatgaa 1320
ggc                                                               1323

<210> 38
<211> 441
<212> PRT
<213> Artificial Sequence

<220> 
<223> tPA_DCPT

<400> 38
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Ser Arg His His His His His His His His Gln Val Cys
        35                  40                  45              
Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His
    50                  55                  60                  
Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly
65                  70                  75                  80  
Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu
                85                  90                  95      
Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln
            100                 105                 110         
Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln
        115                 120                 125             
Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro
    130                 135                 140                 
Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg
145                 150                 155                 160 
Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu
                165                 170                 175     
Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys
            180                 185                 190         
Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr
        195                 200                 205             
Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser
    210                 215                 220                 
Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr
225                 230                 235                 240 
Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp
                245                 250                 255     
Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser
            260                 265                 270         
Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu
        275                 280                 285             
His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met
    290                 295                 300                 
Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala
305                 310                 315                 320 
Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val
                325                 330                 335     
Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg
            340                 345                 350         
Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Gly Thr His Ser Leu Pro
        355                 360                 365             
Pro Arg Pro Ala Ala Val Pro Val Pro Leu Arg Met Gln Pro Gly Pro
    370                 375                 380                 
Ala His Pro Val Leu Ser Phe Leu Arg Pro Ser Trp Asp Leu Val Ser
385                 390                 395                 400 
Ala Phe Tyr Ser Leu Pro Leu Ala Pro Leu Ser Pro Thr Ser Val Pro
                405                 410                 415     
Ile Ser Pro Val Ser Val Gly Arg Gly Pro Asp Pro Asp Ala His Val
            420                 425                 430         
Ala Val Asp Leu Ser Arg Tyr Glu Gly
        435                 440     


<210> 39
<211> 918
<212> DNA
<213> Artificial Sequence

<220> 
<223> tPA-myc-FGFR-2

<400> 39
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga gccctccttc agtttagttg aggatatcac attagagcca 180
gaaggagcac catactggac caacacagaa aagatggaaa agcggctcca tgctgtgcct 240
gcggccaaca ctgtcaagtt tcgctgccca gccgggggga acccaatgcc aaccatgcgg 300
tggctgaaaa acgggaagga gtttaagcag gagcatcgca ttggaggcta caaggtacga 360
aaccagcact ggagcctcat tatggaaagt gtggtcccat ctgacaaggg aaattatacc 420
tgtgtggtgg agaatgaata cgggtccatc aatcacacgt accacctgga tgttgtggag 480
cgatcgcctc accggcccat cctccaagcc ggactgccgg caaacgcctc cacagtggtc 540
ggaggagacg tagagtttgt ctgcaaggtt tacagtgatg cccagcccca catccagtgg 600
atcaagcacg tggaaaagaa cggcagtaaa tacgggcccg acgggctgcc ctacctcaag 660
gttctcaagg ccgccggtgt taacaccacg gacaaagaga ttgaggttct ctatattcgg 720
aatgtaactt ttgaggacgc tggggaatat acgtgcttgg cgggtaattc tattgggata 780
tcctttcact ccgcatggtt gacagttctg ccaggtatat actgttcttt ctctctgggt 840
ttttttcctt tttcttggtt gactgctata aaattaacac agcttctgtt atcagaaatg 900
gcccctttta tccttgca                                               918

<210> 40
<211> 306
<212> PRT
<213> Artificial Sequence

<220> 
<223> tPA-myc-FGFR-2

<400> 40
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Pro
        35                  40                  45              
Ser Phe Ser Leu Val Glu Asp Ile Thr Leu Glu Pro Glu Gly Ala Pro
    50                  55                  60                  
Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val Pro
65                  70                  75                  80  
Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro Met
                85                  90                  95      
Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu His
            100                 105                 110         
Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile Met
        115                 120                 125             
Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Val Val Glu
    130                 135                 140                 
Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val Glu
145                 150                 155                 160 
Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala
                165                 170                 175     
Ser Thr Val Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr Ser
            180                 185                 190         
Asp Ala Gln Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn Gly
        195                 200                 205             
Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala
    210                 215                 220                 
Ala Gly Val Asn Thr Thr Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg
225                 230                 235                 240 
Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn
                245                 250                 255     
Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu Thr Val Leu Pro Gly
            260                 265                 270         
Ile Tyr Cys Ser Phe Ser Leu Gly Phe Phe Pro Phe Ser Trp Leu Thr
        275                 280                 285             
Ala Ile Lys Leu Thr Gln Leu Leu Leu Ser Glu Met Ala Pro Phe Ile
    290                 295                 300                 
Leu Ala
305     


<210> 41
<211> 1404
<212> DNA
<213> Artificial Sequence

<220> 
<223> tPA-myc-FGFR-4

<400> 41
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga ggaggaagtg gagcttgagc cctgcctggc tcccagcctg 180
gagcagcaag agcaggagct gacagtagcc cttgggcagc ctgtgcggct gtgctgtggg 240
cgggctgagc gtggtggcca ctggtacaag gagggcagtc gcctggcacc tgctggccgt 300
gtacggggct ggaggggccg cctagagatt gccagcttcc tacctgagga tgctggccgc 360
tacctctgcc tggcacgagg ctccatgatc gtcctgcaga atctcacctt gattacaggt 420
gactccttga cctccagcaa cgatgatgag gaccccaagt cccataggga cccctcgaat 480
aggcacagtt acccccagca agcaccctac tggacacacc cccagcgcat ggagaagaaa 540
ctgcatgcag tacctgcggg gaacaccgtc aagttccgct gtccagctgc aggcaacccc 600
acgcccacca tccgctggct taaggatgga caggcctttc atggggagaa ccgcattgga 660
ggcattcggc tgcgccatca gcactggagt ctcgtgatgg agagcgtggt gccctcggac 720
cgcggcacat acacctgcct ggtagagaac gctgtgggca gcatctgcta taactacctg 780
ctagatgtgc tggagcggtc cccgcaccgg cccatcctgc aggccgggct cccggccaac 840
accacagccg tggtgggcag cgacgtggag ctgctgtgca aggtgtacag cgatgcccag 900
ccccacatcc agtggctgaa gcacatcgtc atcaacggca gcagcttcgg agccgacggt 960
ttcccctatg tgcaagtcct aaagactgca gacatcaata gctcagaggt ggaggtcctg 1020
tacctgcgga acgtgtcagc cgaggacgca ggcgagtaca cctgcctcgc aggcaattcc 1080
atcggcctct cctaccagtc tgcctggctc acggtgctgc caggtgagca cctgaagggc 1140
caggagatgc tgcgagatgc ccctctgggc cagcagtggg ggctgtggcc tgttgggtgg 1200
tcagtctctg ttggcctgtg gggtctggcc tggggggcag tgtgtggatt tgtgggtttg 1260
agctgtatga cagcccctct gtgcctctcc acacgtggcc gtccatgtga ccgtctgctg 1320
aggtgtgggt gcctgggact gggcataact acagcttcct ccgtgtgtgt ccccacatat 1380
gttgggagct gggagggact gagt                                        1404

<210> 42
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> tPA-myc-FGFR-4

<400> 42
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Glu
        35                  40                  45              
Glu Val Glu Leu Glu Pro Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu
    50                  55                  60                  
Gln Glu Leu Thr Val Ala Leu Gly Gln Pro Val Arg Leu Cys Cys Gly
65                  70                  75                  80  
Arg Ala Glu Arg Gly Gly His Trp Tyr Lys Glu Gly Ser Arg Leu Ala
                85                  90                  95      
Pro Ala Gly Arg Val Arg Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser
            100                 105                 110         
Phe Leu Pro Glu Asp Ala Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser
        115                 120                 125             
Met Ile Val Leu Gln Asn Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr
    130                 135                 140                 
Ser Ser Asn Asp Asp Glu Asp Pro Lys Ser His Arg Asp Pro Ser Asn
145                 150                 155                 160 
Arg His Ser Tyr Pro Gln Gln Ala Pro Tyr Trp Thr His Pro Gln Arg
                165                 170                 175     
Met Glu Lys Lys Leu His Ala Val Pro Ala Gly Asn Thr Val Lys Phe
            180                 185                 190         
Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys
        195                 200                 205             
Asp Gly Gln Ala Phe His Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu
    210                 215                 220                 
Arg His Gln His Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp
225                 230                 235                 240 
Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn Ala Val Gly Ser Ile Cys
                245                 250                 255     
Tyr Asn Tyr Leu Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile
            260                 265                 270         
Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr Ala Val Val Gly Ser Asp
        275                 280                 285             
Val Glu Leu Leu Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln
    290                 295                 300                 
Trp Leu Lys His Ile Val Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly
305                 310                 315                 320 
Phe Pro Tyr Val Gln Val Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu
                325                 330                 335     
Val Glu Val Leu Tyr Leu Arg Asn Val Ser Ala Glu Asp Ala Gly Glu
            340                 345                 350         
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala
        355                 360                 365             
Trp Leu Thr Val Leu Pro Gly Glu His Leu Lys Gly Gln Glu Met Leu
    370                 375                 380                 
Arg Asp Ala Pro Leu Gly Gln Gln Trp Gly Leu Trp Pro Val Gly Trp
385                 390                 395                 400 
Ser Val Ser Val Gly Leu Trp Gly Leu Ala Trp Gly Ala Val Cys Gly
                405                 410                 415     
Phe Val Gly Leu Ser Cys Met Thr Ala Pro Leu Cys Leu Ser Thr Arg
            420                 425                 430         
Gly Arg Pro Cys Asp Arg Leu Leu Arg Cys Gly Cys Leu Gly Leu Gly
        435                 440                 445             
Ile Thr Thr Ala Ser Ser Val Cys Val Pro Thr Tyr Val Gly Ser Trp
    450                 455                 460                 
Glu Gly Leu Ser
465             


<210> 43
<211> 870
<212> DNA
<213> Artificial Sequence

<220> 
<223> tPA-myc-RAGE

<400> 43
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga gcaaaacatc acagcccgga ttggcgagcc actggtgctg 180
aagtgtaagg gggcccccaa gaaaccaccc cagcggctgg aatggaaact gaacacaggc 240
cggacagaag cttggaaggt cctgtctccc cagggaggag gcccctggga cagtgtggct 300
cgtgtccttc ccaacggctc cctcttcctt ccggctgtcg ggatccagga tgaggggatt 360
ttccggtgcc aggcaatgaa caggaatgga aaggagacca agtccaacta ccgagtccgt 420
gtctaccaga tccctgggaa gccagaaatt gtagattctg cctctgaact cacggctggt 480
gttcccaata aggtagtgga agaaagcagg agaagtagaa aacggccctg tgaacaggag 540
gtggggacat gtgtgtcaga gggaagctac cctgcaggga ctcttagctg gcacttggat 600
gggaagcccc tggtgcctaa tgagaaggga gtatctgtga aggaacagac caggagacac 660
cctgagacag ggctcttcac actgcagtcg gagctaatgg tgaccccagc ccggggagga 720
gatccccgtc ccaccttctc ctgtagcttc agcccaggcc ttccccgaca ccgggccttg 780
cgcacagccc ccatccagcc ccgtgtctgg ggtgagcata ggtggggagg gccccaagct 840
cacgtgagca cgttctggaa gtctgaccct                                  870

<210> 44
<211> 290
<212> PRT
<213> Artificial Sequence

<220> 
<223> tPA-myc-RAGE

<400> 44
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Gln
        35                  40                  45              
Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys Lys Gly
    50                  55                  60                  
Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn Thr Gly
65                  70                  75                  80  
Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly Pro Trp
                85                  90                  95      
Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu Pro Ala
            100                 105                 110         
Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met Asn Arg
        115                 120                 125             
Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr Gln Ile
    130                 135                 140                 
Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr Ala Gly
145                 150                 155                 160 
Val Pro Asn Lys Val Val Glu Glu Ser Arg Arg Ser Arg Lys Arg Pro
                165                 170                 175     
Cys Glu Gln Glu Val Gly Thr Cys Val Ser Glu Gly Ser Tyr Pro Ala
            180                 185                 190         
Gly Thr Leu Ser Trp His Leu Asp Gly Lys Pro Leu Val Pro Asn Glu
        195                 200                 205             
Lys Gly Val Ser Val Lys Glu Gln Thr Arg Arg His Pro Glu Thr Gly
    210                 215                 220                 
Leu Phe Thr Leu Gln Ser Glu Leu Met Val Thr Pro Ala Arg Gly Gly
225                 230                 235                 240 
Asp Pro Arg Pro Thr Phe Ser Cys Ser Phe Ser Pro Gly Leu Pro Arg
                245                 250                 255     
His Arg Ala Leu Arg Thr Ala Pro Ile Gln Pro Arg Val Trp Gly Glu
            260                 265                 270         
His Arg Trp Gly Gly Pro Gln Ala His Val Ser Thr Phe Trp Lys Ser
        275                 280                 285             
Asp Pro
    290 


<210> 45
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> tPA-myc-TEK

<400> 45
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga ggtggaaggt gccatggact tgatcttgat caattcccta 180
cctcttgtat ctgatgctga aacatctctc acctgcattg cctctgggtg gcgcccccat 240
gagcccatca ccataggaag ggactttgaa gccttaatga accagcacca ggatccgctg 300
gaagttactc aagatgtgac cagagaatgg gctaaaaaag ttgtttggaa gagagaaaag 360
gctagtaaga tcaatggtgc ttatttctgt gaagggcgag ttcgaggaga ggcaatcagg 420
atacgaacca tgaagatgcg tcaacaagct tccttcctac cagctacttt aactatgact 480
gtggacaagg gagatcacgt gaacatatct ttcaaaaagg tattgattaa agaagaagat 540
gcagcgattt acaaaaatgg ttccttcatc cattcagtgc cccggcatga agtacctgat 600
attctagaag tacacctgcc tcatgctcag ccccaggatg ctggagtgta ctcggccagg 660
tatgtaggag gaaacctctt cacctcggcc ttcaccaggc tgatagtccg gagatgtgaa 720
gcccagaagt ggggacctga atgcaaccat ctctgtactg cttgtatgaa caatggtgtc 780
tgccatgaag atactggaga atgcatttgc cctcctgggt ttatgggaag gacgtgtgag 840
aaggcttgtg aactgcacac gtttggcaga acttgtaaag aaaggtgcag tggacaagag 900
ggatgcaagt cttatgtgtt ctgtctccct gacccctatg ggtgttcctg tgccgcaggc 960
tggaagggtc tgcagtgcaa tgaagcatgc caccctggtt tttacgggcc agattgtaag 1020
cttaggtgca gctgcaacaa tggggagatg tgtgatcgct tccaaggatg tctctgctct 1080
ccaggatggc aggggctcca gtgtgagaga gaaggtaaag caaggcatac cgaggatgac 1140
cccaaagata gtggatttgc cagatcatat agaagtaaac agtgg                 1185

<210> 46
<211> 395
<212> PRT
<213> Artificial Sequence

<220> 
<223> tPA-myc-TEK

<400> 46
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Val
        35                  40                  45              
Glu Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu Pro Leu Val Ser
    50                  55                  60                  
Asp Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly Trp Arg Pro His
65                  70                  75                  80  
Glu Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu Met Asn Gln His
                85                  90                  95      
Gln Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg Glu Trp Ala Lys
            100                 105                 110         
Lys Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile Asn Gly Ala Tyr
        115                 120                 125             
Phe Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg Ile Arg Thr Met
    130                 135                 140                 
Lys Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr Leu Thr Met Thr
145                 150                 155                 160 
Val Asp Lys Gly Asp His Val Asn Ile Ser Phe Lys Lys Val Leu Ile
                165                 170                 175     
Lys Glu Glu Asp Ala Ala Ile Tyr Lys Asn Gly Ser Phe Ile His Ser
            180                 185                 190         
Val Pro Arg His Glu Val Pro Asp Ile Leu Glu Val His Leu Pro His
        195                 200                 205             
Ala Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg Tyr Val Gly Gly
    210                 215                 220                 
Asn Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val Arg Arg Cys Glu
225                 230                 235                 240 
Ala Gln Lys Trp Gly Pro Glu Cys Asn His Leu Cys Thr Ala Cys Met
                245                 250                 255     
Asn Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys Ile Cys Pro Pro
            260                 265                 270         
Gly Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu Leu His Thr Phe
        275                 280                 285             
Gly Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Glu Gly Cys Lys Ser
    290                 295                 300                 
Tyr Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser Cys Ala Ala Gly
305                 310                 315                 320 
Trp Lys Gly Leu Gln Cys Asn Glu Ala Cys His Pro Gly Phe Tyr Gly
                325                 330                 335     
Pro Asp Cys Lys Leu Arg Cys Ser Cys Asn Asn Gly Glu Met Cys Asp
            340                 345                 350         
Arg Phe Gln Gly Cys Leu Cys Ser Pro Gly Trp Gln Gly Leu Gln Cys
        355                 360                 365             
Glu Arg Glu Gly Lys Ala Arg His Thr Glu Asp Asp Pro Lys Asp Ser
    370                 375                 380                 
Gly Phe Ala Arg Ser Tyr Arg Ser Lys Gln Trp
385                 390                 395 


<210> 47
<211> 2790
<212> DNA
<213> Artificial Sequence

<220> 
<223> tPA-myc-RON

<400> 47
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga ggactggcag tgcccgcgca ccccctacgc ggcctctcgc 180
gactttgacg tgaagtacgt ggtgcccagc ttctccgccg gaggcctggt acaggccatg 240
gtgacctacg agggcgacag aaatgagagt gctgtgtttg tagccatacg caatcgcctg 300
catgtgcttg ggcctgacct gaagtctgtc cagagcctgg ccacgggccc tgctggagac 360
cctggctgcc agacgtgtgc agcctgtggc ccaggacccc acggccctcc cggtgacaca 420
gacacaaagg tgctggtgct ggatcccgcg ctgcctgcgc tggtcagttg tggctccagc 480
ctgcagggcc gctgcttcct gcatgaccta gagccccaag ggacagccgt gcatctggca 540
gcgccagcct gccttttctc agcccaccat aaccggcccg atgactgccc cgactgtgtg 600
gccagcccat tgggcacccg tgtaactgtg gttgagcaag gccaggcctc ctatttctac 660
gtggcatcct cactggacgc agccgtggct gccagcttca gcccacgctc agtgtctatc 720
aggcgtctca aggctgacgc ctcgggattc gcaccgggct ttgtggcgtt gtcagtgctg 780
cccaagcatc ttgtctccta cagtattgaa tacgtgcaca gcttccacac gggagccttc 840
gtatacttcc tgactgtaca gccggccagc gtgacagatg atcctagtgc cctgcacaca 900
cgcctggcac ggcttagcgc cactgagcca gagttgggtg actatcggga gctggtcctc 960
gactgcagat ttgctccaaa acgcaggcgc cggggggccc cagaaggcgg acagccctac 1020
cctgtgctgc gggtggccca ctccgctcca gtgggtgccc aacttgccac tgagctgagc 1080
atcgccgagg gccaggaagt actatttggg gtctttgtga ctggcaagga tggtggtcct 1140
ggcgtgggcc ccaactctgt cgtctgtgcc ttccccattg acctgctgga cacactaatt 1200
gatgagggtg tggagcgctg ttgtgaatcc ccagtccatc caggcctccg gcgaggcctc 1260
gacttcttcc agtcgcccag tttttgcccc aacccgcctg gcctggaagc cctcagcccc 1320
aacaccagct gccgccactt ccctctgctg gtcagtagca gcttctcacg tgtggaccta 1380
ttcaatgggc tgttgggacc agtacaggtc actgcattgt atgtgacacg ccttgacaac 1440
gtcacagtgg cacacatggg cacaatggat gggcgtatcc tgcaggtgga gctggtcagg 1500
tcactaaact acttgctgta tgtgtccaac ttctcactgg gtgacagtgg gcagcccgtg 1560
cagcgggatg tcagtcgtct tggggaccac ctactctttg cctctgggga ccaggttttc 1620
caggtaccta tccaaggccc tggctgccgc cacttcctga cctgtgggcg ttgcctaagg 1680
gcatggcatt tcatgggctg tggctggtgt gggaacatgt gcggccagca gaaggagtgt 1740
cctggctcct ggcaacagga ccactgccca cctaagctta ctgagttcca cccccacagt 1800
ggacctctaa ggggcagtac aaggctgacc ctgtgtggct ccaacttcta ccttcaccct 1860
tctggtctgg tgcctgaggg aacccatcag gtcactgtgg gccaaagtcc ctgccggcca 1920
ctgcccaagg acagctcaaa actcagacca gtgccccgga aagactttgt agaggagttt 1980
gagtgtgaac tggagccctt gggcacccag gcagtggggc ctaccaacgt cagcctcacc 2040
gtgactaaca tgccaccggg caagcacttc cgggtagacg gcacctccgt gctgagaggc 2100
ttctctttca tggagccagt gctgatagca gtgcaacccc tctttggccc acgggcagga 2160
ggcacctgtc tcactcttga aggccagagt ctgtctgtag gcaccagccg ggctgtgctg 2220
gtcaatggga ctgagtgtct gctagcacgg gtcagtgagg ggcagctttt atgtgccaca 2280
ccccctgggg ccacggtggc cagtgtcccc cttagcctgc aggtgggggg tgcccaggta 2340
cctggttcct ggaccttcca gtacagagaa gaccctgtcg tgctaagcat cagccccaac 2400
tgtggctaca tcaactccca catcaccatc tgtggccagc atctaacttc agcatggcac 2460
ttagtgctgt cattccatga cgggcttagg gcagtggaaa gcaggcagtg tgagaggcag 2520
cttccagagc agcagctgtg ccgccttcct gaatatgtgg tccgagaccc ccagggatgg 2580
gtggcaggga atctgagtgc ccgaggggat ggagctgctg gctttacact gcctggcttt 2640
cgcttcctac ccccacccca tccacccagt gccaacctag ttccactgaa gcctgaggag 2700
catgccatta agtttgaggt aagtgtaagg gataggggca gggacagttg gggatctgaa 2760
agtaggggcc agcctactgg ctggtcctca                                  2790

<210> 48
<211> 930
<212> PRT
<213> Artificial Sequence

<220> 
<223> tPA-myc-RON

<400> 48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Asp
        35                  40                  45              
Trp Gln Cys Pro Arg Thr Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val
    50                  55                  60                  
Lys Tyr Val Val Pro Ser Phe Ser Ala Gly Gly Leu Val Gln Ala Met
65                  70                  75                  80  
Val Thr Tyr Glu Gly Asp Arg Asn Glu Ser Ala Val Phe Val Ala Ile
                85                  90                  95      
Arg Asn Arg Leu His Val Leu Gly Pro Asp Leu Lys Ser Val Gln Ser
            100                 105                 110         
Leu Ala Thr Gly Pro Ala Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala
        115                 120                 125             
Cys Gly Pro Gly Pro His Gly Pro Pro Gly Asp Thr Asp Thr Lys Val
    130                 135                 140                 
Leu Val Leu Asp Pro Ala Leu Pro Ala Leu Val Ser Cys Gly Ser Ser
145                 150                 155                 160 
Leu Gln Gly Arg Cys Phe Leu His Asp Leu Glu Pro Gln Gly Thr Ala
                165                 170                 175     
Val His Leu Ala Ala Pro Ala Cys Leu Phe Ser Ala His His Asn Arg
            180                 185                 190         
Pro Asp Asp Cys Pro Asp Cys Val Ala Ser Pro Leu Gly Thr Arg Val
        195                 200                 205             
Thr Val Val Glu Gln Gly Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser
    210                 215                 220                 
Leu Asp Ala Ala Val Ala Ala Ser Phe Ser Pro Arg Ser Val Ser Ile
225                 230                 235                 240 
Arg Arg Leu Lys Ala Asp Ala Ser Gly Phe Ala Pro Gly Phe Val Ala
                245                 250                 255     
Leu Ser Val Leu Pro Lys His Leu Val Ser Tyr Ser Ile Glu Tyr Val
            260                 265                 270         
His Ser Phe His Thr Gly Ala Phe Val Tyr Phe Leu Thr Val Gln Pro
        275                 280                 285             
Ala Ser Val Thr Asp Asp Pro Ser Ala Leu His Thr Arg Leu Ala Arg
    290                 295                 300                 
Leu Ser Ala Thr Glu Pro Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu
305                 310                 315                 320 
Asp Cys Arg Phe Ala Pro Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly
                325                 330                 335     
Gly Gln Pro Tyr Pro Val Leu Arg Val Ala His Ser Ala Pro Val Gly
            340                 345                 350         
Ala Gln Leu Ala Thr Glu Leu Ser Ile Ala Glu Gly Gln Glu Val Leu
        355                 360                 365             
Phe Gly Val Phe Val Thr Gly Lys Asp Gly Gly Pro Gly Val Gly Pro
    370                 375                 380                 
Asn Ser Val Val Cys Ala Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile
385                 390                 395                 400 
Asp Glu Gly Val Glu Arg Cys Cys Glu Ser Pro Val His Pro Gly Leu
                405                 410                 415     
Arg Arg Gly Leu Asp Phe Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro
            420                 425                 430         
Pro Gly Leu Glu Ala Leu Ser Pro Asn Thr Ser Cys Arg His Phe Pro
        435                 440                 445             
Leu Leu Val Ser Ser Ser Phe Ser Arg Val Asp Leu Phe Asn Gly Leu
    450                 455                 460                 
Leu Gly Pro Val Gln Val Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn
465                 470                 475                 480 
Val Thr Val Ala His Met Gly Thr Met Asp Gly Arg Ile Leu Gln Val
                485                 490                 495     
Glu Leu Val Arg Ser Leu Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser
            500                 505                 510         
Leu Gly Asp Ser Gly Gln Pro Val Gln Arg Asp Val Ser Arg Leu Gly
        515                 520                 525             
Asp His Leu Leu Phe Ala Ser Gly Asp Gln Val Phe Gln Val Pro Ile
    530                 535                 540                 
Gln Gly Pro Gly Cys Arg His Phe Leu Thr Cys Gly Arg Cys Leu Arg
545                 550                 555                 560 
Ala Trp His Phe Met Gly Cys Gly Trp Cys Gly Asn Met Cys Gly Gln
                565                 570                 575     
Gln Lys Glu Cys Pro Gly Ser Trp Gln Gln Asp His Cys Pro Pro Lys
            580                 585                 590         
Leu Thr Glu Phe His Pro His Ser Gly Pro Leu Arg Gly Ser Thr Arg
        595                 600                 605             
Leu Thr Leu Cys Gly Ser Asn Phe Tyr Leu His Pro Ser Gly Leu Val
    610                 615                 620                 
Pro Glu Gly Thr His Gln Val Thr Val Gly Gln Ser Pro Cys Arg Pro
625                 630                 635                 640 
Leu Pro Lys Asp Ser Ser Lys Leu Arg Pro Val Pro Arg Lys Asp Phe
                645                 650                 655     
Val Glu Glu Phe Glu Cys Glu Leu Glu Pro Leu Gly Thr Gln Ala Val
            660                 665                 670         
Gly Pro Thr Asn Val Ser Leu Thr Val Thr Asn Met Pro Pro Gly Lys
        675                 680                 685             
His Phe Arg Val Asp Gly Thr Ser Val Leu Arg Gly Phe Ser Phe Met
    690                 695                 700                 
Glu Pro Val Leu Ile Ala Val Gln Pro Leu Phe Gly Pro Arg Ala Gly
705                 710                 715                 720 
Gly Thr Cys Leu Thr Leu Glu Gly Gln Ser Leu Ser Val Gly Thr Ser
                725                 730                 735     
Arg Ala Val Leu Val Asn Gly Thr Glu Cys Leu Leu Ala Arg Val Ser
            740                 745                 750         
Glu Gly Gln Leu Leu Cys Ala Thr Pro Pro Gly Ala Thr Val Ala Ser
        755                 760                 765             
Val Pro Leu Ser Leu Gln Val Gly Gly Ala Gln Val Pro Gly Ser Trp
    770                 775                 780                 
Thr Phe Gln Tyr Arg Glu Asp Pro Val Val Leu Ser Ile Ser Pro Asn
785                 790                 795                 800 
Cys Gly Tyr Ile Asn Ser His Ile Thr Ile Cys Gly Gln His Leu Thr
                805                 810                 815     
Ser Ala Trp His Leu Val Leu Ser Phe His Asp Gly Leu Arg Ala Val
            820                 825                 830         
Glu Ser Arg Gln Cys Glu Arg Gln Leu Pro Glu Gln Gln Leu Cys Arg
        835                 840                 845             
Leu Pro Glu Tyr Val Val Arg Asp Pro Gln Gly Trp Val Ala Gly Asn
    850                 855                 860                 
Leu Ser Ala Arg Gly Asp Gly Ala Ala Gly Phe Thr Leu Pro Gly Phe
865                 870                 875                 880 
Arg Phe Leu Pro Pro Pro His Pro Pro Ser Ala Asn Leu Val Pro Leu
                885                 890                 895     
Lys Pro Glu Glu His Ala Ile Lys Phe Glu Val Ser Val Arg Asp Arg
            900                 905                 910         
Gly Arg Asp Ser Trp Gly Ser Glu Ser Arg Gly Gln Pro Thr Gly Trp
        915                 920                 925             
Ser Ser
    930 


<210> 49
<211> 3851
<212> DNA
<213> Artificial Sequence

<220> 
<223> pDrive cloning vector

<400> 49
gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca 60
cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg tgagttagct 120
cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt tgtgtggaat 180
tgtgagcgga taacaatttc acacaggaaa cagctatgac catgattacg ccaagctcta 240
atacgactca ctatagggaa agctcggtac cacgcatgct gcagacgcgt tacgtatcgg 300
atccagaatt cgtgatatct gaattcgtcg acaagcttct cgagcctagg ctagctctag 360
accacacgtg tgggggcccg agctcgcggc cgctgtattc tatagtgtca cctaaatggc 420
cgcacaattc actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc 480
aacttaatcg ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc 540
gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatggaaa ttgtaagcgt 600
taatattttg ttaaaattcg cgttaaattt ttgttaaatc agctcatttt ttaaccaata 660
ggccgaaatc ggcaaaatcc cttataaatc aaaagaatag accgagatag ggttgagtgt 720
tgttccagtt tggaacaaga gtccactatt aaagaacgtg gactccaacg tcaaagggcg 780
aaaaaccgtc tatcagggcg atggcccact acgtgaacca tcaccctaat caagtttttt 840
ggggtcgagg tgccgtaaag cactaaatcg gaaccctaaa gggagccccc gatttagagc 900
ttgacgggga aagccggcga acgtggcgag aaaggaaggg aagaaagcga aaggagcggg 960
cgctagggcg ctggcaagtg tagcggtcac gctgcgcgta accaccacac ccgccgcgct 1020
taatgcgccg ctacagggcg cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc 1080
tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg 1140
ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc 1200
ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt 1260
gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct 1320
caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac 1380
ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact 1440
cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa 1500
gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga 1560
taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt 1620
tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga 1680
agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg 1740
caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat 1800
ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat 1860
tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc 1920
agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga 1980
tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc 2040
agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag 2100
gatctaggtg aagatccttt ttgataatct catgaacaat aaaactgtct gcttacataa 2160
acagtaatac aaggggtgtt atgagccata ttcaacggga aacgtcttgc tctaggccgc 2220
gattaaattc caacatggat gctgatttat atgggtataa atgggctcgc gataatgtcg 2280
ggcaatcagg tgcgacaatc tatcgattgt atgggaagcc cgatgcgcca gagttgtttc 2340
tgaaacatgg caaaggtagc gttgccaatg atgttacaga tgagatggtc agactaaact 2400
ggctgacgga atttatgcct cttccgacca tcaagcattt tatccgtact cctgatgatg 2460
catggttact caccactgcg atccccggga aaacagcatt ccaggtatta gaagaatatc 2520
ctgattcagg tgaaaatatt gttgatgcgc tggcagtgtt cctgcgccgg ttgcattcga 2580
ttcctgtttg taattgtcct tttaacagcg atcgcgtatt tcgtctcgct caggcgcaat 2640
cacgaatgaa taacggtttg gttgatgcga gtgattttga tgacgagcgt aatggctggc 2700
ctgttgaaca agtctggaaa gaaatgcata aacttttgcc attctcaccg gattcagtcg 2760
tcactcatgg tgatttctca cttgataacc ttatttttga cgaggggaaa ttaataggtt 2820
gtattgatgt tggacgagtc ggaatcgcag accgatacca ggatcttgcc atcctatgga 2880
actgcctcgg tgagttttct ccttcattac agaaacggct ttttcaaaaa tatggtattg 2940
ataatcctga tatgaataaa ttgcagtttc atttgatgct cgatgagttt ttctaagaat 3000
taattcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta 3060
gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa 3120
acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt 3180
tttccgaagg taactggctt cagcagagcg cagataccaa atactgtcct tctagtgtag 3240
ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta 3300
atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca 3360
agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag 3420
cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa 3480
agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga 3540
acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc 3600
gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc 3660
ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt 3720
gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt 3780
gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag 3840
gaagcggaag a                                                      3851

<210> 50
<211> 4006
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCI expression vector

<400> 50
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta 60
ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc 120
aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg 180
gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc 240
gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat 300
agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc 360
ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga 420
cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg 480
gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac 540
caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt 600
caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc 660
cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc 720
tcgtttagtg aaccgtcaga tcactagaag ctttattgcg gtagtttatc acagttaaat 780
tgctaacgca gtcagtgctt ctgacacaac agtctcgaac ttaagctgca gaagttggtc 840
gtgaggcact gggcaggtaa gtatcaaggt tacaagacag gtttaaggag accaatagaa 900
actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta ttggtcttac 960
tgacatccac tttgcctttc tctccacagg tgtccactcc cagttcaatt acagctctta 1020
aggctagagt acttaatacg actcactata ggctagcctc gagaattcac gcgtggtacc 1080
tctagagtcg acccgggcgg ccgcttcgag cagacatgat aagatacatt gatgagtttg 1140
gacaaaccac aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta 1200
ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac aattgcattc 1260
attttatgtt tcaggttcag ggggagatgt gggaggtttt ttaaagcaag taaaacctct 1320
acaaatgtgg taaaatcgat aaggatccgg gctggcgtaa tagcgaagag gcccgcaccg 1380
atcgcccttc ccaacagttg cgcagcctga atggcgaatg gacgcgccct gtagcggcgc 1440
attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct 1500
agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg 1560
tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga 1620
ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt 1680
ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg 1740
aacaacactc aaccctatct cggtctattc ttttgattta taagggattt tgccgatttc 1800
ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt ttaacaaaat 1860
attaacgctt acaatttcct gatgcggtat tttctcctta cgcatctgtg cggtatttca 1920
caccgcatat ggtgcactct cagtacaatc tgctctgatg ccgcatagtt aagccagccc 1980
cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct 2040
tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca 2100
ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg 2160
ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct 2220
atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga 2280
taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc 2340
cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg 2400
aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc 2460
aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact 2520
tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc 2580
ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag 2640
catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat 2700
aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt 2760
ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa 2820
gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac aacgttgcgc 2880
aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg 2940
gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt 3000
gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca 3060
gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat 3120
gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca 3180
gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg 3240
atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg 3300
ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt 3360
ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg 3420
ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata 3480
ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca 3540
ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag 3600
tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc 3660
tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga 3720
tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg 3780
tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac 3840
gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg 3900
tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg 3960
ttcctggcct tttgctggcc ttttgctcac atggctcgac agatct                4006

<210> 51
<211> 5446
<212> DNA
<213> Artificial Sequence

<220> 
<223> pcDNA 3.1 expression vector

<400> 51
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg 60
ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg 120
cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc 180
ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt 240
gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata 300
tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc 360
cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc 420
attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt 480
atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt 540
atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca 600
tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg 660
actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc 720
aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg 780
gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca 840
ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc 900
gagctcggat ccactagtaa cggccgccag tgtgctggaa ttctgcagat atccatcaca 960
ctggcggccg ctcgagcatg catctagagg gccctattct atagtgtcac ctaaatgcta 1020
gagctcgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct 1080
cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 1140
aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 1200
aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat gcggtgggct 1260
ctatggcttc tgaggcggaa agaaccagct ggggctctag ggggtatccc cacgcgccct 1320
gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg 1380
ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg 1440
gctttccccg tcaagctcta aatcggggca tccctttagg gttccgattt agtgctttac 1500
ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct 1560
gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt 1620
tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta taagggattt 1680
tggggatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt 1740
aattctgtgg aatgtgtgtc agttagggtg tggaaagtcc ccaggctccc caggcaggca 1800
gaagtatgca aagcatgcat ctcaattagt cagcaaccag gtgtggaaag tccccaggct 1860
ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc atagtcccgc 1920
ccctaactcc gcccatcccg cccctaactc cgcccagttc cgcccattct ccgccccatg 1980
gctgactaat tttttttatt tatgcagagg ccgaggccgc ctctgcctct gagctattcc 2040
agaagtagtg aggaggcttt tttggaggcc taggcttttg caaaaagctc ccgggagctt 2100
gtatatccat tttcggatct gatcaagaga caggatgagg atcgtttcgc atgattgaac 2160
aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc ggctatgact 2220
gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca gcgcaggggc 2280
gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg caggacgagg 2340
cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg ctcgacgttg 2400
tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag gatctcctgt 2460
catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg cggcggctgc 2520
atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc atcgagcgag 2580
cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa gagcatcagg 2640
ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg catgcccgac ggcgaggatc 2700
tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat ggccgctttt 2760
ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac atagcgttgg 2820
ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt 2880
acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt gacgagttct 2940
tctgagcggg actctggggt tcgaaatgac cgaccaagcg acgcccaacc tgccatcacg 3000
agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg ttttccggga 3060
cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg cccaccccaa 3120
cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa 3180
taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta 3240
tcatgtctgt ataccgtcga cctctagcta gagcttggcg taatcatggt catagctgtt 3300
tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg gaagcataaa 3360
gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt tgcgctcact 3420
gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc 3480
ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg 3540
ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa tacggttatc 3600
cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc aaaaggccag 3660
gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca 3720
tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca 3780
ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg 3840
atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcaatgct cacgctgtag 3900
gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt 3960
tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca 4020
cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg 4080
cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa ggacagtatt 4140
tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc 4200
cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg 4260
cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg 4320
gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta 4380
gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg agtaaacttg 4440
gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct gtctatttcg 4500
ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg agggcttacc 4560
atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc cagatttatc 4620
agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc 4680
ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc cagttaatag 4740
tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt cgtttggtat 4800
ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc ccatgttgtg 4860
caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt 4920
gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc catccgtaag 4980
atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt gtatgcggcg 5040
accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata gcagaacttt 5100
aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct 5160
gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag catcttttac 5220
tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat 5280
aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt attgaagcat 5340
ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga aaaataaaca 5400
aataggggtt ccgcgcacat ttccccgaaa agtgccacct gacgtc                5446



<210> 52
<211> 32
<212> PRT
<213> Mus musculus

<220>
<223> tPA pro

<400> 52
Met Lys Arg Glu Leu Leu Cys Val Leu Leu Leu Cys Gly Leu Ala Phe
 1               5                  10                  15      
Pro Leu Pro Asp Gln Gly Ile His Gly Arg Phe Arg Arg Gly Ala Arg
            20                  25                  30          


<210> 53
<211> 32
<212> PRT
<213> Rattus norvegicus

<220>
<223> tPA pro 

<400> 53
Met Lys Gly Glu Leu Leu Cys Val Leu Leu Leu Cys Gly Val Ala Phe
 1               5                  10                  15      
Thr Leu Pro Asp Gln Gly Ile His Arg Arg Phe Arg Arg Gly Ala Arg
            20                  25                  30          


<210> 54
<211> 36
<212> PRT
<213> Bos taurus

<220>
<223> tPA pro 

<400> 54
Met Met Ser Ala Met Lys Thr Glu Phe Leu Cys Val Leu Leu Leu Cys
 1               5                  10                  15      
Gly Ala Val Phe Thr Ser Pro Ser Gln Glu Thr Tyr Arg Arg Leu Arg
            20                  25                  30          
Arg Gly Ala Arg
        35      


<210> 55
<211> 35
<212> PRT
<213> Pongo pygmaeus

<220>
<223> tPA pro

<400> 55
Met Asn Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Ala Leu Pro Ser Gln Glu Ile His Ala Arg Val Arg Arg
            20                  25                  30          
Gly Ala Arg
        35  


<210> 56
<211> 35
<212> PRT
<213> Sus scrofa

<220>
<223> tPA pro 

<400> 56
Met Tyr Ala Leu Lys Arg Glu Leu Trp Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Ile Cys Thr Ser Pro Ser Gln Glu Thr His Arg Arg Leu Arg Arg
            20                  25                  30          
Gly Val Arg
        35  


<210> 57
<211> 38
<212> PRT
<213> Gallus gallus

<220>
<223> tPA pro

<400> 57
Met Trp Lys Thr Leu Arg Met Lys Gly Lys Leu Leu Ser Leu Leu Leu
 1               5                  10                  15      
Leu Val Gly Val Ile Lys Thr Ala Gln Cys Gln Gly Thr His Met Arg
            20                  25                  30          
Tyr Lys Arg Gly Ala Arg
        35              


<210> 58
<211> 36
<212> PRT
<213> Desmodus rotundus

<220>
<223> tPA pro

<400> 58
Met Val Asn Thr Met Lys Thr Lys Leu Leu Cys Val Leu Leu Leu Cys
 1               5                  10                  15      
Gly Ala Val Phe Ser Leu Pro Arg Gln Glu Thr Tyr Arg Gln Leu Ala
            20                  25                  30          
Arg Gly Ser Arg
        35      


<210> 59
<211> 36
<212> PRT
<213> Oryctolagus cuniculus

<220>
<223> tPA pro

<400> 59
Met Trp Asn Pro Gly Val Arg Glu Leu Leu Cys Val Leu Leu Leu Cys
 1               5                  10                  15      
Gly Ala Ala Cys Ala Arg Pro Ser Gln Glu Ala Pro Ala Arg Val Arg
            20                  25                  30          
Arg Gly Ala Arg
        35      


<210> 60
<211> 22
<212> PRT
<213> Erwinia carotovora

<220>
<223> PelB

<400> 60
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala
 1               5                  10                  15      
Ala Gln Pro Ala Met Ala
            20          


<210> 61
<211> 21
<212> PRT
<213> Escherichia coli

<220>
<223> OmpA

<400> 61
Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala
 1               5                  10                  15      
Thr Val Ala Gln Ala
            20      


<210> 62
<211> 23
<212> PRT
<213> Escherichia coli

<220>
<223> Stll

<400> 62
Met Lys Lys Asn Ile Ala Phe Leu Leu Ala Ser Met Phe Val Phe Ser
 1               5                  10                  15      
Ile Ala Thr Asn Ala Tyr Ala
            20              


<210> 63
<211> 28
<212> PRT
<213> Bacillus sp.

<220>
<223> End

<400> 63
Met Phe Lys Phe Lys Lys Lys Phe Leu Val Gly Leu Thr Ala Ala Phe
 1               5                  10                  15      
Met Ser Ile Ser Met Phe Ser Ala Thr Ala Ser Ala
            20                  25              


<210> 64
<211> 21
<212> PRT
<213> Escherichia coli

<220>
<223> PhoA

<400> 64
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr
 1               5                  10                  15      
Pro Val Thr Lys Ala
            20      


<210> 65
<211> 22
<212> PRT
<213> Escherichia coli

<220>
<223> OmpF

<400> 65
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val
 1               5                  10                  15      
Ala Gly Thr Ala Asn Ala
            20          


<210> 66
<211> 21
<212> PRT
<213> Escherichia coli

<220>
<223> PhoE

<400> 66
Met Lys Lys Ser Thr Leu Ala Leu Val Val Met Gly Ile Val Ala Ser
 1               5                  10                  15      
Ala Ser Val Gln Ala
            20      


<210> 67
<211> 26
<212> PRT
<213> Escherichia coli

<220>
<223> MalE

<400> 67
Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr
 1               5                  10                  15      
Thr Met Met Phe Ser Ala Ser Ala Leu Ala
            20                  25      


<210> 68
<211> 21
<212> PRT
<213> Escherichia coli

<220>
<223> OmpC

<400> 68
Met Lys Val Lys Val Leu Ser Leu Leu Val Pro Ala Leu Leu Val Ala
 1               5                  10                  15      
Gly Ala Ala Asn Ala
            20      


<210> 69
<211> 20
<212> PRT
<213> Escherichia coli

<220>
<223> Lpp

<400> 69
Met Lys Ala Thr Lys Leu Val Leu Gly Ala Val Ile Leu Gly Ser Thr
 1               5                  10                  15      
Leu Leu Ala Gly
            20  


<210> 70
<211> 19
<212> PRT
<213> Serratia Marcesens

<220>
<223> Lipoprotein

<400> 70
Met Asn Arg Thr Lys Leu Val Leu Gly Ala Val Ile Leu Gly Ser His
 1               5                  10                  15      
Ser Ala Gly
            


<210> 71
<211> 25
<212> PRT
<213> Escherichia coli

<220>
<223> LamB

<400> 71
Met Met Ile Thr Leu Arg Lys Leu Pro Leu Ala Val Ala Val Ala Ala
 1               5                  10                  15      
Gly Val Met Ser Ala Gln Ala Met Ala
            20                  25  


<210> 72
<211> 20
<212> PRT
<213> Escherichia coli

<220>
<223> OmpT

<400> 72
Met Arg Ala Lys Leu Leu Gly Ile Val Leu Thr Thr Pro Ile Ala Ile
 1               5                  10                  15      
Ser Ser Phe Ala
            20  


<210> 73
<211> 21
<212> PRT
<213> Escherichia coli

<220>
<223> LTB

<400> 73
Met Asn Lys Val Lys Cys Tyr Val Leu Phe Thr Ala Leu Leu Ser Ser
 1               5                  10                  15      
Leu Tyr Ala His Gly
            20      


<210> 74
<211> 25
<212> PRT
<213> Escherichia coli

<220>
<223> RsbS

<400> 74
Met Asn Met Lys Lys Leu Ala Thr Leu Val Ser Ala Val Ala Leu Ser
 1               5                  10                  15      
Ala Thr Val Ser Ala Asn Ala Met Ala
            20                  25  


<210> 75
<211> 18
<212> PRT
<213> Escherichia coli

<220>
<223> LTA

<400> 75
Met Lys Asn Ile Thr Phe Ile Phe Phe Ile Leu Leu Ala Ser Pro Leu
 1               5                  10                  15      
Tyr Ala
        


<210> 76
<211> 24
<212> PRT
<213> Staphylococcus aureus

<400> 76
Met Lys Lys Leu Ile Phe Leu Ile Val Ile Ala Leu Val Leu Ser Ala
 1               5                  10                  15      
Cys Asn Ser Asn Ser Ser His Ala
            20                  


<210> 77
<211> 36
<212> PRT
<213> Staphylococcus aureus

<400> 77
Met Lys Lys Lys Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile
 1               5                  10                  15      
Ala Ser Val Thr Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro
            20                  25                  30          
Ala Ala Asn Ala
        35      


<210> 78
<211> 23
<212> PRT
<213> Escherichia coli

<400> 78
Met Ser Ile Gln His Phe Arg Val Ala Leu Ile Pro Phe Phe Ala Ala
 1               5                  10                  15      
Phe Cys Leu Pro Val Phe Ala
            20              


<210> 79
<211> 19
<212> PRT
<213> Escherichia coli

<400> 79
Met Met Lys Lys Thr Ile Thr Leu Leu Thr Ala Leu Leu Pro Leu Ala
 1               5                  10                  15      
Ser Ala Val
            


<210> 80
<211> 18
<212> PRT
<213> Bacteriophage M13

<400> 80
Met Lys Lys Leu Leu Phe Ala Ile Pro Leu Val Val Pro Phe Tyr Ser
 1               5                  10                  15      
His Ser
        


<210> 81
<211> 19
<212> PRT
<213> Saccharomyces cerevisiae

<400> 81
Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser
 1               5                  10                  15      
Ala Leu Ala
            


<210> 82
<211> 18
<212> PRT
<213> Schizosaccharomyces pombe

<400> 82
Met Phe Leu Gln Asn Leu Phe Leu Gly Phe Leu Ala Val Val Cys Ala
 1               5                  10                  15      
Asn Ala
        


<210> 83
<211> 16
<212> PRT
<213> Kluyveromyces lactis

<400> 83
Met Leu Val Ser Asp Ser Ser Val Asp Gly Gly Glu Arg Arg Ser Ser
 1               5                  10                  15      


<210> 84
<211> 19
<212> PRT
<213> Saccharomyces cerevisiae

<400> 84
Met Leu Leu Gln Ala Phe Leu Phe Leu Leu Ala Gly Phe Ala Ala Lys
 1               5                  10                  15      
Ile Ser Ala
            


<210> 85
<211> 30
<212> PRT
<213> Nichotiana tabacum

<400> 85
Met Gly Phe Phe Leu Phe Ser Gln Met Pro Ser Phe Phe Leu Val Ser
 1               5                  10                  15      
Thr Leu Leu Leu Phe Leu Ile Ile Ser His Ser Ser His Ala
            20                  25                  30  


<210> 86
<211> 40
<212> PRT
<213> Autographa californica

<400> 86
Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr
 1               5                  10                  15      
Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala
            20                  25                  30          
Ala His Ser Ala Phe Ala Ala Gly
        35                  40  


<210> 87
<211> 21
<212> PRT
<213> Apis mellifera

<400> 87
Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile
 1               5                  10                  15      
Ser Tyr Ile Tyr Ala
            20      


<210> 88
<211> 18
<212> PRT
<213> Autographa californica

<400> 88
Met Thr Ile Leu Cys Trp Leu Ala Leu Leu Ser Thr Leu Thr Ala Val
 1               5                  10                  15      
Asn Ala
        


<210> 89
<211> 23
<212> PRT
<213> Homo sapiens

<400> 89
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser
            20              


<210> 90
<211> 17
<212> PRT
<213> Homo sapiens

<400> 90
Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu Ser Leu
 1               5                  10                  15      
Gly
    


<210> 91
<211> 26
<212> PRT
<213> Homo sapiens

<400> 91
Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu
 1               5                  10                  15      
Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala
            20                  25      


<210> 92
<211> 18
<212> PRT
<213> Homo sapiens

<400> 92
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala
 1               5                  10                  15      
Tyr Ser
        


<210> 93
<211> 32
<212> PRT
<213> Homo sapiens

<400> 93
Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu
 1               5                  10                  15      
Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala
            20                  25                  30          


<210> 94
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> AU1

<400> 94
Asp Thr Tyr Arg Tyr Ile
 1               5      


<210> 95
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> AU5

<400> 95
Thr Asp Phe Tyr Leu Lys
 1               5      


<210> 96
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DDDDK

<400> 96
Asp Asp Asp Asp Lys
 1               5  


<210> 97
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> c-myc

<400> 97
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu
 1               5                  10  


<210> 98
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> E-tag

<400> 98
Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg
 1               5                  10              


<210> 99
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223>  HA

<400> 99
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala
 1               5                  


<210> 100
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Poly-His

<400> 100
His His His His His His
 1               5      


<210> 101
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> E2 tag

<400> 101
Gly Val Ser Ser Thr Ser Ser Asp Phe Arg Asp Arg
 1               5                  10          


<210> 102
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> HSV

<400> 102
Ser Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp
 1               5                  10          


<210> 103
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> KT3

<400> 103
Lys Pro Pro Thr Pro Pro Pro Glu Pro Glu Thr
 1               5                  10      


<210> 104
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> S-tag

<400> 104
Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser
 1               5                  10                  15  


<210> 105
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VSV-G

<400> 105
Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys
 1               5                  10      


<210> 106
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> T7

<400> 106
Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly
 1               5                  10      


<210> 107
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> V5

<400> 107
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr
 1               5                  10                  


<210> 108
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glu-Glu

<400> 108
Glu Tyr Met Pro Met Glu
 1               5      


<210> 109
<211> 1024
<212> PRT
<213> Escherichia coli

<400> 109
Met Thr Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp
 1               5                  10                  15      
Trp Glu Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro
            20                  25                  30          
Pro Phe Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro
        35                  40                  45              
Ser Gln Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe
    50                  55                  60                  
Pro Ala Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro
65                  70                  75                  80  
Glu Ala Asp Thr Val Val Val Pro Ser Asn Trp Gln Met His Gly Tyr
                85                  90                  95      
Asp Ala Pro Ile Tyr Thr Asn Val Thr Tyr Pro Ile Thr Val Asn Pro
            100                 105                 110         
Pro Phe Val Pro Thr Glu Asn Pro Thr Gly Cys Tyr Ser Leu Thr Phe
        115                 120                 125             
Asn Val Asp Glu Ser Trp Leu Gln Glu Gly Gln Thr Arg Ile Ile Phe
    130                 135                 140                 
Asp Gly Val Asn Ser Ala Phe His Leu Trp Cys Asn Gly Arg Trp Val
145                 150                 155                 160 
Gly Tyr Gly Gln Asp Ser Arg Leu Pro Ser Glu Phe Asp Leu Ser Ala
                165                 170                 175     
Phe Leu Arg Ala Gly Glu Asn Arg Leu Ala Val Met Val Leu Arg Trp
            180                 185                 190         
Ser Asp Gly Ser Tyr Leu Glu Asp Gln Asp Met Trp Arg Met Ser Gly
        195                 200                 205             
Ile Phe Arg Asp Val Ser Leu Leu His Lys Pro Thr Thr Gln Ile Ser
    210                 215                 220                 
Asp Phe His Val Ala Thr Arg Phe Asn Asp Asp Phe Ser Arg Ala Val
225                 230                 235                 240 
Leu Glu Ala Glu Val Gln Met Cys Gly Glu Leu Arg Asp Tyr Leu Arg
                245                 250                 255     
Val Thr Val Ser Leu Trp Gln Gly Glu Thr Gln Val Ala Ser Gly Thr
            260                 265                 270         
Ala Pro Phe Gly Gly Glu Ile Ile Asp Glu Arg Gly Gly Tyr Ala Asp
        275                 280                 285             
Arg Val Thr Leu Arg Leu Asn Val Glu Asn Pro Lys Leu Trp Ser Ala
    290                 295                 300                 
Glu Ile Pro Asn Leu Tyr Arg Ala Val Val Glu Leu His Thr Ala Asp
305                 310                 315                 320 
Gly Thr Leu Ile Glu Ala Glu Ala Cys Asp Val Gly Phe Arg Glu Val
                325                 330                 335     
Arg Ile Glu Asn Gly Leu Leu Leu Leu Asn Gly Lys Pro Leu Leu Ile
            340                 345                 350         
Arg Gly Val Asn Arg His Glu His His Pro Leu His Gly Gln Val Met
        355                 360                 365             
Asp Glu Gln Thr Met Val Gln Asp Ile Leu Leu Met Lys Gln Asn Asn
    370                 375                 380                 
Phe Asn Ala Val Arg Cys Ser His Tyr Pro Asn His Pro Leu Trp Tyr
385                 390                 395                 400 
Thr Leu Cys Asp Arg Tyr Gly Leu Tyr Val Val Asp Glu Ala Asn Ile
                405                 410                 415     
Glu Thr His Gly Met Val Pro Met Asn Arg Leu Thr Asp Asp Pro Arg
            420                 425                 430         
Trp Leu Pro Ala Met Ser Glu Arg Val Thr Arg Met Val Gln Arg Asp
        435                 440                 445             
Arg Asn His Pro Ser Val Ile Ile Trp Ser Leu Gly Asn Glu Ser Gly
    450                 455                 460                 
His Gly Ala Asn His Asp Ala Leu Tyr Arg Trp Ile Lys Ser Val Asp
465                 470                 475                 480 
Pro Ser Arg Pro Val Gln Tyr Glu Gly Gly Gly Ala Asp Thr Thr Ala
                485                 490                 495     
Thr Asp Ile Ile Cys Pro Met Tyr Ala Arg Val Asp Glu Asp Gln Pro
            500                 505                 510         
Phe Pro Ala Val Pro Lys Trp Ser Ile Lys Lys Trp Leu Ser Leu Pro
        515                 520                 525             
Gly Glu Thr Arg Pro Leu Ile Leu Cys Glu Tyr Ala His Ala Met Gly
    530                 535                 540                 
Asn Ser Leu Gly Gly Phe Ala Lys Tyr Trp Gln Ala Phe Arg Gln Tyr
545                 550                 555                 560 
Pro Arg Leu Gln Gly Gly Phe Val Trp Asp Trp Val Asp Gln Ser Leu
                565                 570                 575     
Ile Lys Tyr Asp Glu Asn Gly Asn Pro Trp Ser Ala Tyr Gly Gly Asp
            580                 585                 590         
Phe Gly Asp Thr Pro Asn Asp Arg Gln Phe Cys Met Asn Gly Leu Val
        595                 600                 605             
Phe Ala Asp Arg Thr Pro His Pro Ala Leu Thr Glu Ala Lys His Gln
    610                 615                 620                 
Gln Gln Phe Phe Gln Phe Arg Leu Ser Gly Gln Thr Ile Glu Val Thr
625                 630                 635                 640 
Ser Glu Tyr Leu Phe Arg His Ser Asp Asn Glu Leu Leu His Trp Met
                645                 650                 655     
Val Ala Leu Asp Gly Lys Pro Leu Ala Ser Gly Glu Val Pro Leu Asp
            660                 665                 670         
Val Ala Pro Gln Gly Lys Gln Leu Ile Glu Leu Pro Glu Leu Pro Gln
        675                 680                 685             
Pro Glu Ser Ala Gly Gln Leu Trp Leu Thr Val Arg Val Val Gln Pro
    690                 695                 700                 
Asn Ala Thr Ala Trp Ser Glu Ala Gly His Ile Ser Ala Trp Gln Gln
705                 710                 715                 720 
Trp Arg Leu Ala Glu Asn Leu Ser Val Thr Leu Pro Ala Ala Ser His
                725                 730                 735     
Ala Ile Pro His Leu Thr Thr Ser Glu Met Asp Phe Cys Ile Glu Leu
            740                 745                 750         
Gly Asn Lys Arg Trp Gln Phe Asn Arg Gln Ser Gly Phe Leu Ser Gln
        755                 760                 765             
Met Trp Ile Gly Asp Lys Lys Gln Leu Leu Thr Pro Leu Arg Asp Gln
    770                 775                 780                 
Phe Thr Arg Ala Pro Leu Asp Asn Asp Ile Gly Val Ser Glu Ala Thr
785                 790                 795                 800 
Arg Ile Asp Pro Asn Ala Trp Val Glu Arg Trp Lys Ala Ala Gly His
                805                 810                 815     
Tyr Gln Ala Glu Ala Ala Leu Leu Gln Cys Thr Ala Asp Thr Leu Ala
            820                 825                 830         
Asp Ala Val Leu Ile Thr Thr Ala His Ala Trp Gln His Gln Gly Lys
        835                 840                 845             
Thr Leu Phe Ile Ser Arg Lys Thr Tyr Arg Ile Asp Gly Ser Gly Gln
    850                 855                 860                 
Met Ala Ile Thr Val Asp Val Glu Val Ala Ser Asp Thr Pro His Pro
865                 870                 875                 880 
Ala Arg Ile Gly Leu Asn Cys Gln Leu Ala Gln Val Ala Glu Arg Val
                885                 890                 895     
Asn Trp Leu Gly Leu Gly Pro Gln Glu Asn Tyr Pro Asp Arg Leu Thr
            900                 905                 910         
Ala Ala Cys Phe Asp Arg Trp Asp Leu Pro Leu Ser Asp Met Tyr Thr
        915                 920                 925             
Pro Tyr Val Phe Pro Ser Glu Asn Gly Leu Arg Cys Gly Thr Arg Glu
    930                 935                 940                 
Leu Asn Tyr Gly Pro His Gln Trp Arg Gly Asp Phe Gln Phe Asn Ile
945                 950                 955                 960 
Ser Arg Tyr Ser Gln Gln Gln Leu Met Glu Thr Ser His Arg His Leu
                965                 970                 975     
Leu His Ala Glu Glu Gly Thr Trp Leu Asn Ile Asp Gly Phe His Met
            980                 985                 990         
Gly Ile Gly Gly Asp Asp Ser Trp Ser Pro Ser Val Ser Ala Glu Phe
        995                 1000                1005            
Gln Leu Ser Ala Gly Arg Tyr His Tyr Gln Leu Val Trp Cys Gln Lys
    1010                1015                1020                


<210> 110
<211> 881
<212> PRT
<213> Saccharomyces cerevisiae

<400> 110
Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu
 1               5                  10                  15      
Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu
            20                  25                  30          
Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro
        35                  40                  45              
Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu
    50                  55                  60                  
Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile
65                  70                  75                  80  
Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu
                85                  90                  95      
Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala
            100                 105                 110         
Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser
        115                 120                 125             
Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu
    130                 135                 140                 
Thr Val Ser Ile Asp Ser Ala Ala His His Asp Asn Ser Thr Ile Pro
145                 150                 155                 160 
Leu Asp Phe Met Pro Arg Asp Ala Leu His Gly Phe Asp Trp Ser Glu
                165                 170                 175     
Glu Asp Asp Met Ser Asp Gly Leu Pro Phe Leu Lys Thr Asp Pro Asn
            180                 185                 190         
Asn Asn Gly Phe Phe Gly Asp Gly Ser Leu Leu Cys Ile Leu Arg Ser
        195                 200                 205             
Ile Gly Phe Lys Pro Glu Asn Tyr Thr Asn Ser Asn Val Asn Arg Leu
    210                 215                 220                 
Pro Thr Met Ile Thr Asp Arg Tyr Thr Leu Ala Ser Arg Ser Thr Thr
225                 230                 235                 240 
Ser Arg Leu Leu Gln Ser Tyr Leu Asn Asn Phe His Pro Tyr Cys Pro
                245                 250                 255     
Ile Val His Ser Pro Thr Leu Met Met Leu Tyr Asn Asn Gln Ile Glu
            260                 265                 270         
Ile Ala Ser Lys Asp Gln Trp Gln Ile Leu Phe Asn Cys Ile Leu Ala
        275                 280                 285             
Ile Gly Ala Trp Cys Ile Glu Gly Glu Ser Thr Asp Ile Asp Val Phe
    290                 295                 300                 
Tyr Tyr Gln Asn Ala Lys Ser His Leu Thr Ser Lys Val Phe Glu Ser
305                 310                 315                 320 
Gly Ser Ile Ile Leu Val Thr Ala Leu His Leu Leu Ser Arg Tyr Thr
                325                 330                 335     
Gln Trp Arg Gln Lys Thr Asn Thr Ser Tyr Asn Phe His Ser Phe Ser
            340                 345                 350         
Ile Arg Met Ala Ile Ser Leu Gly Leu Asn Arg Asp Leu Pro Ser Ser
        355                 360                 365             
Phe Ser Asp Ser Ser Ile Leu Glu Gln Arg Arg Arg Ile Trp Trp Ser
    370                 375                 380                 
Val Tyr Ser Trp Glu Ile Gln Leu Ser Leu Leu Tyr Gly Arg Ser Ile
385                 390                 395                 400 
Gln Leu Ser Gln Asn Thr Ile Ser Phe Pro Ser Ser Val Asp Asp Val
                405                 410                 415     
Gln Arg Thr Thr Thr Gly Pro Thr Ile Tyr His Gly Ile Ile Glu Thr
            420                 425                 430         
Ala Arg Leu Leu Gln Val Phe Thr Lys Ile Tyr Glu Leu Asp Lys Thr
        435                 440                 445             
Val Thr Ala Glu Lys Ser Pro Ile Cys Ala Lys Lys Cys Leu Met Ile
    450                 455                 460                 
Cys Asn Glu Ile Glu Glu Val Ser Arg Gln Ala Pro Lys Phe Leu Gln
465                 470                 475                 480 
Met Asp Ile Ser Thr Thr Ala Leu Thr Asn Leu Leu Lys Glu His Pro
                485                 490                 495     
Trp Leu Ser Phe Thr Arg Phe Glu Leu Lys Trp Lys Gln Leu Ser Leu
            500                 505                 510         
Ile Ile Tyr Val Leu Arg Asp Phe Phe Thr Asn Phe Thr Gln Lys Lys
        515                 520                 525             
Ser Gln Leu Glu Gln Asp Gln Asn Asp His Gln Ser Tyr Glu Val Lys
    530                 535                 540                 
Arg Cys Ser Ile Met Leu Ser Asp Ala Ala Gln Arg Thr Val Met Ser
545                 550                 555                 560 
Val Ser Ser Tyr Met Asp Asn His Asn Val Thr Pro Tyr Phe Ala Trp
                565                 570                 575     
Asn Cys Ser Tyr Tyr Leu Phe Asn Ala Val Leu Val Pro Ile Lys Thr
            580                 585                 590         
Leu Leu Ser Asn Ser Lys Ser Asn Ala Glu Asn Asn Glu Thr Ala Gln
        595                 600                 605             
Leu Leu Gln Gln Ile Asn Thr Val Leu Met Leu Leu Lys Lys Leu Ala
    610                 615                 620                 
Thr Phe Lys Ile Gln Thr Cys Glu Lys Tyr Ile Gln Val Leu Glu Glu
625                 630                 635                 640 
Val Cys Ala Pro Phe Leu Leu Ser Gln Cys Ala Ile Pro Leu Pro His
                645                 650                 655     
Ile Ser Tyr Asn Asn Ser Asn Gly Ser Ala Ile Lys Asn Ile Val Gly
            660                 665                 670         
Ser Ala Thr Ile Ala Gln Tyr Pro Thr Leu Pro Glu Glu Asn Val Asn
        675                 680                 685             
Asn Ile Ser Val Lys Tyr Val Ser Pro Gly Ser Val Gly Pro Ser Pro
    690                 695                 700                 
Val Pro Leu Lys Ser Gly Ala Ser Phe Ser Asp Leu Val Lys Leu Leu
705                 710                 715                 720 
Ser Asn Arg Pro Pro Ser Arg Asn Ser Pro Val Thr Ile Pro Arg Ser
                725                 730                 735     
Thr Pro Ser His Arg Ser Val Thr Pro Phe Leu Gly Gln Gln Gln Gln
            740                 745                 750         
Leu Gln Ser Leu Val Pro Leu Thr Pro Ser Ala Leu Phe Gly Gly Ala
        755                 760                 765             
Asn Phe Asn Gln Ser Gly Asn Ile Ala Asp Ser Ser Leu Ser Phe Thr
    770                 775                 780                 
Phe Thr Asn Ser Ser Asn Gly Pro Asn Leu Ile Thr Thr Gln Thr Asn
785                 790                 795                 800 
Ser Gln Ala Leu Ser Gln Pro Ile Ala Ser Ser Asn Val His Asp Asn
                805                 810                 815     
Phe Met Asn Asn Glu Ile Thr Ala Ser Lys Ile Asp Asp Gly Asn Asn
            820                 825                 830         
Ser Lys Pro Leu Ser Pro Gly Trp Thr Asp Gln Thr Ala Tyr Asn Ala
        835                 840                 845             
Phe Gly Ile Thr Thr Gly Met Phe Asn Thr Thr Thr Met Asp Asp Val
    850                 855                 860                 
Tyr Asn Tyr Leu Phe Asp Asp Glu Asp Thr Pro Pro Asn Pro Lys Lys
865                 870                 875                 880 
Glu
    


<210> 111
<211> 326
<212> PRT
<213> Vibrio fischeri

<400> 111
Met Lys Phe Gly Leu Phe Phe Leu Asn Phe Gln Lys Asp Gly Ile Thr
 1               5                  10                  15      
Ser Glu Glu Thr Leu Asp Asn Met Val Lys Thr Val Thr Leu Ile Asp
            20                  25                  30          
Ser Thr Lys Tyr His Phe Asn Thr Ala Phe Val Asn Glu His His Phe
        35                  40                  45              
Ser Lys Asn Gly Ile Val Gly Ala Pro Ile Thr Ala Ala Gly Phe Leu
    50                  55                  60                  
Leu Gly Leu Thr Asn Lys Leu His Ile Gly Ser Leu Asn Gln Val Ile
65                  70                  75                  80  
Thr Thr His His Pro Val Arg Val Ala Glu Glu Ala Ser Leu Leu Asp
                85                  90                  95      
Gln Met Ser Glu Gly Arg Phe Ile Leu Gly Phe Ser Asp Cys Glu Ser
            100                 105                 110         
Asp Phe Glu Met Glu Phe Phe Arg Arg His Ile Ser Ser Arg Gln Gln
        115                 120                 125             
Gln Phe Glu Ala Cys Tyr Glu Ile Ile Asn Asp Ala Leu Thr Thr Gly
    130                 135                 140                 
Tyr Cys His Pro Gln Asn Asp Phe Tyr Asp Phe Pro Lys Val Ser Ile
145                 150                 155                 160 
Asn Pro His Cys Tyr Ser Glu Asn Gly Pro Lys Gln Tyr Val Ser Ala
                165                 170                 175     
Thr Ser Lys Glu Val Val Met Trp Ala Ala Lys Lys Ala Leu Pro Leu
            180                 185                 190         
Thr Phe Lys Trp Glu Asp Asn Leu Glu Thr Lys Glu Arg Tyr Ala Ile
        195                 200                 205             
Leu Tyr Asn Lys Thr Ala Gln Gln Tyr Gly Ile Asp Ile Ser Asp Val
    210                 215                 220                 
Asp His Gln Leu Thr Val Ile Ala Asn Leu Asn Ala Asp Arg Ser Thr
225                 230                 235                 240 
Ala Gln Glu Glu Val Arg Glu Tyr Leu Lys Asp Tyr Ile Thr Glu Thr
                245                 250                 255     
Tyr Pro Gln Met Asp Arg Asp Glu Lys Ile Asn Cys Ile Ile Glu Glu
            260                 265                 270         
Asn Ala Val Gly Ser His Asp Asp Tyr Tyr Glu Ser Thr Lys Leu Ala
        275                 280                 285             
Val Glu Lys Thr Gly Ser Lys Asn Ile Leu Leu Ser Phe Glu Ser Met
    290                 295                 300                 
Ser Asp Ile Lys Asp Val Lys Asp Ile Ile Asp Met Leu Asn Gln Lys
305                 310                 315                 320 
Ile Glu Met Asn Leu Pro
                325     


<210> 112
<211> 354
<212> PRT
<213> Vibrio fischeri

<400> 112
Met Lys Phe Gly Asn Ile Cys Phe Ser Tyr Gln Pro Pro Gly Glu Thr
 1               5                  10                  15      
His Lys Leu Ser Asn Gly Ser Leu Cys Ser Ala Trp Tyr Arg Leu Arg
            20                  25                  30          
Arg Val Gly Phe Asp Thr Tyr Trp Thr Leu Glu His His Phe Thr Glu
        35                  40                  45              
Phe Gly Leu Thr Gly Asn Leu Phe Val Ala Ala Ala Asn Leu Leu Gly
    50                  55                  60                  
Arg Thr Lys Thr Leu Asn Val Gly Thr Met Gly Val Val Ile Pro Thr
65                  70                  75                  80  
Ala His Pro Val Arg Gln Leu Glu Asp Val Leu Leu Leu Asp Gln Met
                85                  90                  95      
Ser Lys Gly Arg Phe Asn Phe Gly Thr Val Arg Gly Leu Tyr His Lys
            100                 105                 110         
Asp Phe Arg Val Phe Gly Val Asp Met Glu Glu Ser Arg Ala Ile Thr
        115                 120                 125             
Gln Asn Phe Tyr Gln Met Ile Met Glu Ser Leu Gln Thr Gly Thr Ile
    130                 135                 140                 
Ser Ser Asp Ser Asp Tyr Ile Gln Phe Pro Lys Val Asp Val Tyr Pro
145                 150                 155                 160 
Lys Val Tyr Ser Lys Asn Val Pro Thr Cys Met Thr Ala Glu Ser Ala
                165                 170                 175     
Ser Thr Thr Glu Trp Leu Ala Ile Gln Gly Leu Pro Met Val Leu Ser
            180                 185                 190         
Trp Ile Ile Gly Thr Asn Glu Lys Lys Ala Gln Met Glu Leu Tyr Asn
        195                 200                 205             
Glu Ile Ala Thr Glu Tyr Gly His Asp Ile Ser Lys Ile Asp His Cys
    210                 215                 220                 
Met Thr Tyr Ile Cys Ser Val Asp Asp Asp Ala Gln Lys Ala Gln Asp
225                 230                 235                 240 
Val Cys Arg Glu Phe Leu Lys Asn Trp Tyr Asp Ser Tyr Val Asn Ala
                245                 250                 255     
Thr Asn Ile Phe Asn Asp Ser Asn Gln Thr Arg Gly Tyr Asp Tyr His
            260                 265                 270         
Lys Gly Gln Trp Arg Asp Phe Val Leu Gln Gly His Thr Asn Thr Asn
        275                 280                 285             
Arg Arg Val Asp Tyr Ser Asn Gly Ile Asn Pro Val Gly Thr Pro Glu
    290                 295                 300                 
Gln Cys Ile Glu Ile Ile Gln Arg Asp Ile Asp Ala Thr Gly Ile Thr
305                 310                 315                 320 
Asn Ile Thr Cys Gly Phe Glu Ala Asn Gly Thr Glu Asp Glu Ile Ile
                325                 330                 335     
Ala Ser Met Arg Arg Phe Met Thr Gln Val Ala Pro Phe Leu Lys Glu
            340                 345                 350         
Pro Lys
        


<210> 113
<211> 550
<212> PRT
<213> Photinus pyralis

<400> 113
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro
 1               5                  10                  15      
Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg
            20                  25                  30          
Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu
        35                  40                  45              
Val Asn Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala
    50                  55                  60                  
Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val
65                  70                  75                  80  
Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu
                85                  90                  95      
Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg
            100                 105                 110         
Glu Leu Leu Asn Ser Met Asn Ile Ser Gln Pro Thr Val Val Phe Val
        115                 120                 125             
Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro
    130                 135                 140                 
Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly
145                 150                 155                 160 
Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe
                165                 170                 175     
Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile
            180                 185                 190         
Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val
        195                 200                 205             
Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp
    210                 215                 220                 
Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val
225                 230                 235                 240 
Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu
                245                 250                 255     
Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu
            260                 265                 270         
Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val
        275                 280                 285             
Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr
    290                 295                 300                 
Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser
305                 310                 315                 320 
Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile
                325                 330                 335     
Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr
            340                 345                 350         
Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe
        355                 360                 365             
Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val
    370                 375                 380                 
Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly
385                 390                 395                 400 
Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly
                405                 410                 415     
Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe
            420                 425                 430         
Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln
        435                 440                 445             
Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile
    450                 455                 460                 
Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu
465                 470                 475                 480 
Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys
                485                 490                 495     
Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu
            500                 505                 510         
Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly
        515                 520                 525             
Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys
    530                 535                 540                 
Gly Gly Lys Ser Lys Leu
545                 550 


<210> 114
<211> 396
<212> PRT
<213> Escherichia coli

<400> 114
Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr
 1               5                  10                  15      
Thr Met Met Phe Ser Ala Ser Ala Leu Ala Lys Ile Glu Glu Gly Lys
            20                  25                  30          
Leu Val Ile Trp Ile Asn Gly Asp Lys Gly Tyr Asn Gly Leu Ala Glu
        35                  40                  45              
Val Gly Lys Lys Phe Glu Lys Asp Thr Gly Ile Lys Val Thr Val Glu
    50                  55                  60                  
His Pro Asp Lys Leu Glu Glu Lys Phe Pro Gln Val Ala Ala Thr Gly
65                  70                  75                  80  
Asp Gly Pro Asp Ile Ile Phe Trp Ala His Asp Arg Phe Gly Gly Tyr
                85                  90                  95      
Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr Pro Asp Lys Ala Phe Gln
            100                 105                 110         
Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala Val Arg Tyr Asn Gly Lys
        115                 120                 125             
Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala Leu Ser Leu Ile Tyr Asn
    130                 135                 140                 
Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr Trp Glu Glu Ile Pro Ala
145                 150                 155                 160 
Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys Ser Ala Leu Met Phe Asn
                165                 170                 175     
Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu Ile Ala Ala Asp Gly Gly
            180                 185                 190         
Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr Asp Ile Lys Asp Val Gly
        195                 200                 205             
Val Asp Asn Ala Gly Ala Lys Ala Gly Leu Thr Phe Leu Val Asp Leu
    210                 215                 220                 
Ile Lys Asn Lys His Met Asn Ala Asp Thr Asp Tyr Ser Ile Ala Glu
225                 230                 235                 240 
Ala Ala Phe Asn Lys Gly Glu Thr Ala Met Thr Ile Asn Gly Pro Trp
                245                 250                 255     
Ala Trp Ser Asn Ile Asp Thr Ser Lys Val Asn Tyr Gly Val Thr Val
            260                 265                 270         
Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys Pro Phe Val Gly Val Leu
        275                 280                 285             
Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn Lys Glu Leu Ala Lys Glu
    290                 295                 300                 
Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu Gly Leu Glu Ala Val Asn
305                 310                 315                 320 
Lys Asp Lys Pro Leu Gly Ala Val Ala Leu Lys Ser Tyr Glu Glu Glu
                325                 330                 335     
Leu Ala Lys Asp Pro Arg Ile Ala Ala Thr Met Glu Asn Ala Gln Lys
            340                 345                 350         
Gly Glu Ile Met Pro Asn Ile Pro Gln Met Ser Ala Phe Trp Tyr Ala
        355                 360                 365             
Val Arg Thr Ala Val Ile Asn Ala Ala Ser Gly Arg Gln Thr Val Asp
    370                 375                 380                 
Glu Ala Leu Lys Asp Ala Gln Thr Arg Ile Thr Lys
385                 390                 395     


<210> 115
<211> 524
<212> PRT
<213> Staphylococcus aureus

<400> 115
Met Lys Lys Lys Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile
 1               5                  10                  15      
Ala Ser Val Thr Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro
            20                  25                  30          
Ala Ala Asn Ala Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr
        35                  40                  45              
Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe
    50                  55                  60                  
Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly
65                  70                  75                  80  
Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln
                85                  90                  95      
Gln Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu
            100                 105                 110         
Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser
        115                 120                 125             
Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys
    130                 135                 140                 
Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys
145                 150                 155                 160 
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn
                165                 170                 175     
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser
            180                 185                 190         
Gln Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln
        195                 200                 205             
Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe
    210                 215                 220                 
Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly
225                 230                 235                 240 
Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu
                245                 250                 255     
Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn
            260                 265                 270         
Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu
        275                 280                 285             
Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys
    290                 295                 300                 
Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu
305                 310                 315                 320 
Asn Asp Ala Gln Ala Pro Lys Glu Glu Asp Asn Asn Lys Pro Gly Lys
                325                 330                 335     
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys
            340                 345                 350         
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys
        355                 360                 365             
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys
    370                 375                 380                 
Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys
385                 390                 395                 400 
Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys
                405                 410                 415     
Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Gly Val His Val
            420                 425                 430         
Val Lys Pro Gly Asp Thr Val Asn Asp Ile Ala Lys Ala Asn Gly Thr
        435                 440                 445             
Thr Ala Asp Lys Ile Ala Ala Asp Asn Lys Leu Ala Asp Lys Asn Met
    450                 455                 460                 
Ile Lys Pro Gly Gln Glu Leu Val Val Asp Lys Lys Gln Pro Ala Asn
465                 470                 475                 480 
His Ala Asp Ala Asn Lys Ala Gln Ala Leu Pro Glu Thr Gly Glu Glu
                485                 490                 495     
Asn Pro Phe Ile Gly Thr Thr Val Phe Gly Gly Leu Ser Leu Ala Leu
            500                 505                 510         
Gly Ala Ala Leu Leu Ala Gly Arg Arg Arg Glu Leu
        515                 520                 


<210> 116
<211> 448
<212> PRT
<213> Streptococcus sp.

<400> 116
Met Glu Lys Glu Lys Lys Val Lys Tyr Phe Leu Arg Lys Ser Ala Phe
 1               5                  10                  15      
Gly Leu Ala Ser Val Ser Ala Ala Phe Leu Val Gly Ser Thr Val Phe
            20                  25                  30          
Ala Val Asp Ser Pro Ile Glu Asp Thr Pro Ile Ile Arg Asn Gly Gly
        35                  40                  45              
Glu Leu Thr Asn Leu Leu Gly Asn Ser Glu Thr Thr Leu Ala Leu Arg
    50                  55                  60                  
Asn Glu Glu Ser Ala Thr Ala Asp Leu Thr Ala Ala Ala Val Ala Asp
65                  70                  75                  80  
Thr Val Ala Ala Ala Ala Ala Glu Asn Ala Gly Ala Ala Ala Trp Glu
                85                  90                  95      
Ala Ala Ala Ala Ala Asp Ala Leu Ala Lys Ala Lys Ala Asp Ala Leu
            100                 105                 110         
Lys Glu Phe Asn Lys Tyr Gly Val Ser Asp Tyr Tyr Lys Asn Leu Ile
        115                 120                 125             
Asn Asn Ala Lys Thr Val Glu Gly Ile Lys Asp Leu Gln Ala Gln Val
    130                 135                 140                 
Val Glu Ser Ala Lys Lys Ala Arg Ile Ser Glu Ala Thr Asp Gly Leu
145                 150                 155                 160 
Ser Asp Phe Leu Lys Ser Gln Thr Pro Ala Glu Asp Thr Val Lys Ser
                165                 170                 175     
Ile Glu Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys
            180                 185                 190         
Tyr Gly Val Ser Asp Tyr His Lys Asn Leu Ile Asn Asn Ala Lys Thr
        195                 200                 205             
Val Glu Gly Val Lys Glu Leu Ile Asp Glu Ile Leu Ala Ala Leu Pro
    210                 215                 220                 
Lys Thr Asp Thr Tyr Lys Leu Ile Leu Asn Gly Lys Thr Leu Lys Gly
225                 230                 235                 240 
Glu Thr Thr Thr Glu Ala Val Asp Ala Ala Thr Ala Glu Lys Val Phe
                245                 250                 255     
Lys Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu Trp Thr Tyr Asp
            260                 265                 270         
Asp Ala Thr Lys Thr Phe Thr Val Thr Glu Lys Pro Glu Val Ile Asp
        275                 280                 285             
Ala Ser Glu Leu Thr Pro Ala Val Thr Thr Tyr Lys Leu Val Ile Asn
    290                 295                 300                 
Gly Lys Thr Leu Lys Gly Glu Thr Thr Thr Lys Ala Val Asp Ala Glu
305                 310                 315                 320 
Thr Ala Glu Lys Ala Phe Lys Gln Tyr Ala Asn Asp Asn Gly Val Asp
                325                 330                 335     
Gly Val Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe Thr Val Thr Glu
            340                 345                 350         
Met Val Thr Glu Val Pro Gly Asp Ala Pro Thr Glu Pro Glu Lys Pro
        355                 360                 365             
Glu Ala Ser Ile Pro Leu Val Pro Leu Thr Pro Ala Thr Pro Ile Ala
    370                 375                 380                 
Lys Asp Asp Ala Lys Lys Asp Asp Thr Lys Lys Glu Asp Ala Lys Lys
385                 390                 395                 400 
Pro Glu Ala Lys Lys Asp Asp Ala Lys Lys Ala Glu Thr Leu Pro Thr
                405                 410                 415     
Thr Gly Glu Gly Ser Asn Pro Phe Phe Thr Ala Ala Ala Leu Ala Val
            420                 425                 430         
Met Ala Gly Ala Gly Ala Leu Ala Val Ala Ser Lys Arg Lys Glu Asp
        435                 440                 445             


<210> 117
<211> 238
<212> PRT
<213> Aequorea victoria

<400> 117
Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val
 1               5                  10                  15      
Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu
            20                  25                  30          
Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys
        35                  40                  45              
Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe
    50                  55                  60                  
Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln
65                  70                  75                  80  
His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg
                85                  90                  95      
Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val
            100                 105                 110         
Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile
        115                 120                 125             
Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn
    130                 135                 140                 
Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly
145                 150                 155                 160 
Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val
                165                 170                 175     
Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro
            180                 185                 190         
Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser
        195                 200                 205             
Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val
    210                 215                 220                 
Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys
225                 230                 235             


<210> 118
<211> 101
<212> PRT
<213> Homo sapiens

<400> 118
Met Ser Asp Gln Glu Ala Lys Pro Ser Thr Glu Asp Leu Gly Asp Lys
 1               5                  10                  15      
Lys Glu Gly Glu Tyr Ile Lys Leu Lys Val Ile Gly Gln Asp Ser Ser
            20                  25                  30          
Glu Ile His Phe Lys Val Lys Met Thr Thr His Leu Lys Lys Leu Lys
        35                  40                  45              
Glu Ser Tyr Cys Gln Arg Gln Gly Val Pro Met Asn Ser Leu Arg Phe
    50                  55                  60                  
Leu Phe Glu Gly Gln Arg Ile Ala Asp Asn His Thr Pro Lys Glu Leu
65                  70                  75                  80  
Gly Met Glu Glu Glu Asp Val Ile Glu Val Tyr Gln Glu Gln Thr Gly
                85                  90                  95      
Gly His Ser Thr Val
            100     


<210> 119
<211> 495
<212> PRT
<213> Homo sapiens

<400> 119
Met Asn Lys Glu Ile Leu Ala Val Val Glu Ala Val Ser Asn Glu Lys
 1               5                  10                  15      
Ala Leu Pro Arg Glu Lys Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala
            20                  25                  30          
Thr Ala Thr Lys Lys Lys Tyr Glu Gln Glu Ile Asp Val Arg Val Gln
        35                  40                  45              
Ile Asp Arg Lys Ser Gly Asp Phe Asp Thr Phe Arg Arg Trp Leu Val
    50                  55                  60                  
Val Asp Glu Val Thr Gln Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala
65                  70                  75                  80  
Arg Tyr Glu Asp Glu Ser Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln
                85                  90                  95      
Ile Glu Ser Val Thr Phe Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln
            100                 105                 110         
Val Ile Val Gln Lys Val Arg Glu Ala Glu Arg Ala Met Val Val Asp
        115                 120                 125             
Gln Phe Arg Glu His Glu Gly Glu Ile Ile Thr Gly Val Val Lys Lys
    130                 135                 140                 
Val Asn Arg Asp Asn Ile Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala
145                 150                 155                 160 
Val Ile Leu Arg Glu Asp Met Leu Pro Arg Glu Asn Phe Arg Pro Gly
                165                 170                 175     
Asp Arg Val Arg Gly Val Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly
            180                 185                 190         
Ala Gln Leu Phe Val Thr Arg Ser Lys Pro Glu Met Leu Ile Glu Leu
        195                 200                 205             
Phe Arg Ile Glu Val Pro Glu Ile Gly Glu Glu Val Ile Glu Ile Lys
    210                 215                 220                 
Ala Ala Ala Arg Asp Pro Gly Ser Arg Ala Lys Ile Ala Val Lys Thr
225                 230                 235                 240 
Asn Asp Lys Arg Ile Asp Pro Val Gly Ala Cys Val Gly Met Arg Gly
                245                 250                 255     
Ala Arg Val Gln Ala Val Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp
            260                 265                 270         
Ile Val Leu Trp Asp Asp Asn Pro Ala Gln Phe Val Ile Asn Ala Met
        275                 280                 285             
Ala Pro Ala Asp Val Ala Ser Ile Val Val Asp Glu Asp Lys His Thr
    290                 295                 300                 
Met Asp Ile Ala Val Glu Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg
305                 310                 315                 320 
Asn Gly Gln Asn Val Arg Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu
                325                 330                 335     
Asn Val Met Thr Val Asp Asp Leu Gln Ala Lys His Gln Ala Glu Ala
            340                 345                 350         
His Ala Ala Ile Asp Thr Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp
        355                 360                 365             
Phe Ala Thr Val Leu Val Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu
    370                 375                 380                 
Ala Tyr Val Pro Met Lys Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu
385                 390                 395                 400 
Pro Thr Val Glu Ala Leu Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr
                405                 410                 415     
Ile Ala Gln Ala Gln Glu Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp
            420                 425                 430         
Asp Leu Leu Asn Leu Glu Gly Val Asp Arg Asp Leu Ala Phe Lys Leu
        435                 440                 445             
Ala Ala Arg Gly Val Cys Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile
    450                 455                 460                 
Asp Asp Leu Ala Asp Ile Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala
465                 470                 475                 480 
Leu Ile Met Ala Ala Arg Asn Ile Cys Trp Phe Gly Asp Glu Ala
                485                 490                 495 


<210> 120
<211> 495
<212> PRT
<213> Escherichia coli

<400> 120
Met Asn Lys Glu Ile Leu Ala Val Val Glu Ala Val Ser Asn Glu Lys
 1               5                  10                  15      
Ala Leu Pro Arg Glu Lys Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala
            20                  25                  30          
Thr Ala Thr Lys Lys Lys Tyr Glu Gln Glu Ile Asp Val Arg Val Gln
        35                  40                  45              
Ile Asp Arg Lys Ser Gly Asp Phe Asp Thr Phe Arg Arg Trp Leu Val
    50                  55                  60                  
Val Asp Glu Val Thr Gln Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala
65                  70                  75                  80  
Arg Tyr Glu Asp Glu Ser Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln
                85                  90                  95      
Ile Glu Ser Val Thr Phe Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln
            100                 105                 110         
Val Ile Val Gln Lys Val Arg Glu Ala Glu Arg Ala Met Val Val Asp
        115                 120                 125             
Gln Phe Arg Glu His Glu Gly Glu Ile Ile Thr Gly Val Val Lys Lys
    130                 135                 140                 
Val Asn Arg Asp Asn Ile Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala
145                 150                 155                 160 
Val Ile Leu Arg Glu Asp Met Leu Pro Arg Glu Asn Phe Arg Pro Gly
                165                 170                 175     
Asp Arg Val Arg Gly Val Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly
            180                 185                 190         
Ala Gln Leu Phe Val Thr Arg Ser Lys Pro Glu Met Leu Ile Glu Leu
        195                 200                 205             
Phe Arg Ile Glu Val Pro Glu Ile Gly Glu Glu Val Ile Glu Ile Lys
    210                 215                 220                 
Ala Ala Ala Arg Asp Pro Gly Ser Arg Ala Lys Ile Ala Val Lys Thr
225                 230                 235                 240 
Asn Asp Lys Arg Ile Asp Pro Val Gly Ala Cys Val Gly Met Arg Gly
                245                 250                 255     
Ala Arg Val Gln Ala Val Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp
            260                 265                 270         
Ile Val Leu Trp Asp Asp Asn Pro Ala Gln Phe Val Ile Asn Ala Met
        275                 280                 285             
Ala Pro Ala Asp Val Ala Ser Ile Val Val Asp Glu Asp Lys His Thr
    290                 295                 300                 
Met Asp Ile Ala Val Glu Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg
305                 310                 315                 320 
Asn Gly Gln Asn Val Arg Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu
                325                 330                 335     
Asn Val Met Thr Val Asp Asp Leu Gln Ala Lys His Gln Ala Glu Ala
            340                 345                 350         
His Ala Ala Ile Asp Thr Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp
        355                 360                 365             
Phe Ala Thr Val Leu Val Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu
    370                 375                 380                 
Ala Tyr Val Pro Met Lys Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu
385                 390                 395                 400 
Pro Thr Val Glu Ala Leu Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr
                405                 410                 415     
Ile Ala Gln Ala Gln Glu Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp
            420                 425                 430         
Asp Leu Leu Asn Leu Glu Gly Val Asp Arg Asp Leu Ala Phe Lys Leu
        435                 440                 445             
Ala Ala Arg Gly Val Cys Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile
    450                 455                 460                 
Asp Asp Leu Ala Asp Ile Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala
465                 470                 475                 480 
Leu Ile Met Ala Ala Arg Asn Ile Cys Trp Phe Gly Asp Glu Ala
                485                 490                 495 


<210> 121
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Streptag

<400> 121
Ala Trp Arg His Pro Gln Phe Gly Gly
 1               5                  


<210> 122
<211> 109
<212> PRT
<213> Escherichia coli

<400> 122
Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp
 1               5                  10                  15      
Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp
            20                  25                  30          
Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp
        35                  40                  45              
Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn
    50                  55                  60                  
Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu
65                  70                  75                  80  
Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser
                85                  90                  95      
Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala
            100                 105                 


<210> 123
<211> 218
<212> PRT
<213> Schistosoma japonicum

<400> 123
Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro
 1               5                  10                  15      
Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu
            20                  25                  30          
Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu
        35                  40                  45              
Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys
    50                  55                  60                  
Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn
65                  70                  75                  80  
Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu
                85                  90                  95      
Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser
            100                 105                 110         
Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu
        115                 120                 125             
Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn
    130                 135                 140                 
Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp
145                 150                 155                 160 
Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu
                165                 170                 175     
Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr
            180                 185                 190         
Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala
        195                 200                 205             
Thr Phe Gly Gly Gly Asp His Pro Pro Lys
    210                 215             


<210> 124
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> FLAG

<400> 124
Asp Tyr Lys Asp Asp Asp Asp Lys
 1               5              


<210> 125
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein C

<400> 125
Glu Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys
 1               5                  10          


<210> 126
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tag-100

<400> 126
Glu Glu Thr Ala Arg Phe Gln Pro Gly Tyr Arg Ser
 1               5                  10          


<210> 127
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> T7 gene 10

<400> 127
Asp Leu Tyr Asp Asp Asp Asp Lys
 1               5              


<210> 128
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223>  XhoI linker

<400> 128
ctcgag                                                            6

<210> 129
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> XbaI linker

<400> 129
tctaga                                                            6

<210> 130
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> NheI linker

<400> 130
gctagc                                                            6

<210> 131
<211> 8
<212> DNA
<213> Artificial Sequence

<220> 
<223> NotI linker

<400> 131
gcggccgc                                                          8

<210> 132
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> EcoRI linker

<400> 132
gaattc                                                            6

<210> 133
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Thrombin cleavage site

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = R or K

<400> 133
Leu Val Pro Xaa Gly Ser
 1               5      


<210> 134
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Enterokinase cleavage site

<400> 134
Asp Asp Asp Asp Lys
 1               5  


<210> 135
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> VARIANT        
<222> 6
<223> Xaa=Q or G

<220> 
<223> TEV-protease

<400> 135
Glu Asn Leu Tyr Phe Xaa
 1               5      


<210> 136
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> VARIANT        
<222> 2
<223> Xaa=D or E

<220> 
<223> Factor Xa cleavage site

<400> 136
Ile Xaa Gly Arg
 1              


<210> 137
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> VARIANT        
<222> 3
<223> Xaa=D or E

<220> 
<223> Genease I  cleavage site

<400> 137
His Tyr Xaa
 1          


<210> 138
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> VARIANT        
<222> 6
<223> Xaa=Q or G

<220> 
<223> preScission  cleavage site

<400> 138
Leu Glu Val Leu Phe Xaa Pro
 1               5          

<210> 139
<211> 984
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (37)...(897)
<223> SR005A11

<400> 139
tgcccccacc cccttaggcc cgagggatca ggagct atg gga cca gag gcc ctg   54
                                        Met Gly Pro Glu Ala Leu
                                         1               5
 
tca tct tta ctg ctg ctg ctc ttg gtg gca agt gga gat gct gac atg   102
Ser Ser Leu Leu Leu Leu Leu Leu Val Ala Ser Gly Asp Ala Asp Met
             10                  15                  20
 
aag gga cat ttt gat cct gcc aag tgc cgc tat gcc ctg ggc atg cag   150
Lys Gly His Phe Asp Pro Ala Lys Cys Arg Tyr Ala Leu Gly Met Gln
         25                  30                  35
 
gac cgg acc atc cca gac agt gac atc tct gct tcc agc tcc tgg tca   198
Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser Ala Ser Ser Ser Trp Ser
     40                  45                  50
 
gat tcc act gcc gcc cgc cac agc agg ttg gag agc agt gac ggg gat   246
Asp Ser Thr Ala Ala Arg His Ser Arg Leu Glu Ser Ser Asp Gly Asp
 55                  60                  65                  70
 
ggg gcc tgg tgc ccc gca ggg tcg gtg ttt ccc aag gag gag gag tac   294
Gly Ala Trp Cys Pro Ala Gly Ser Val Phe Pro Lys Glu Glu Glu Tyr
                 75                  80                  85
 
ttg cag gtg gat cta caa cga ctg cac ctg gtg gct ctg gtg ggc acc   342
Leu Gln Val Asp Leu Gln Arg Leu His Leu Val Ala Leu Val Gly Thr
             90                  95                 100
 
cag gga cgg cat gcc ggg ggc ctg ggc aag gag ttc tcc cgg agc tac   390
Gln Gly Arg His Ala Gly Gly Leu Gly Lys Glu Phe Ser Arg Ser Tyr
        105                 110                 115
 
cgg ctg cgt tac tcc cgg gat ggt cgc cgc tgg atg ggc tgg aag gac   438
Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg Trp Met Gly Trp Lys Asp
    120                 125                 130
 
cgc tgg ggt cag gag gtg atc tca ggc aat gag gac cct gag gga gtg   486
Arg Trp Gly Gln Glu Val Ile Ser Gly Asn Glu Asp Pro Glu Gly Val
135                 140                 145                 150
 
gtg ctg aag gac ctt ggg ccc ccc atg gtt gcc cga ctg gtt cgc ttc   534
Val Leu Lys Asp Leu Gly Pro Pro Met Val Ala Arg Leu Val Arg Phe
                155                 160                 165
 
tac ccc cgg gct gac cgg gtc atg agc gtc tgt ctg cgg gta gag ctc   582
Tyr Pro Arg Ala Asp Arg Val Met Ser Val Cys Leu Arg Val Glu Leu
            170                 175                 180
 
tat ggc tgc ctc tgg agg gat gga ctc ctg tct tac acc gcc cct gtg   630
Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu Ser Tyr Thr Ala Pro Val
        185                 190                 195
 
ggg cag aca atg tat tta tct gag gcc gtg tac ctc aac gac tcc acc   678
Gly Gln Thr Met Tyr Leu Ser Glu Ala Val Tyr Leu Asn Asp Ser Thr
    200                 205                 210
 
tat gac gga cat acc gtg ggc gga ctg cag tat ggg ggt ctg ggc cag   726
Tyr Asp Gly His Thr Val Gly Gly Leu Gln Tyr Gly Gly Leu Gly Gln
215                 220                 225                 230
 
ctg gca gat ggt gtg gtg ggg ctg gat gac ttt agg aag agt cag gag   774
Leu Ala Asp Gly Val Val Gly Leu Asp Asp Phe Arg Lys Ser Gln Glu
                235                 240                 245
 
ctg cgg gtc tgg cca ggc tat gac tat gtg gga tgg agc aac cac agc   822
Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val Gly Trp Ser Asn His Ser
            250                 255                 260
 
ttc tcc agt ggc tat gtg gag atg gag ttt gag ttt gac cgg ctg agg   870
Phe Ser Ser Gly Tyr Val Glu Met Glu Phe Glu Phe Asp Arg Leu Arg
        265                 270                 275
 
gcc ttc cag gct atg cag atg tgg tga acaattcctc tccggcactg         917
Ala Phe Gln Ala Met Gln Met Trp  *
    280                 285
 
ggaggcacct tcccgccagc cccctggtgg ccgcctggcc cacctcccac caacttcagc 977
agcttgg                                                           984

<210> 140
<211> 286
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR005A11

<400> 140
Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala
 1               5                  10                  15      
Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg
            20                  25                  30          
Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser
        35                  40                  45              
Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu
    50                  55                  60                  
Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe
65                  70                  75                  80  
Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu
                85                  90                  95      
Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys
            100                 105                 110         
Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg
        115                 120                 125             
Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn
    130                 135                 140                 
Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val
145                 150                 155                 160 
Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val
                165                 170                 175     
Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu
            180                 185                 190         
Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val
        195                 200                 205             
Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln
    210                 215                 220                 
Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp
225                 230                 235                 240 
Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val
                245                 250                 255     
Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe
            260                 265                 270         
Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Met Trp
        275                 280                 285     

<210> 141
<211> 788
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (37)...(768)
<223> SR005A10

<400> 141
tgcccccacc cccttaggcc cgagggatca ggagct atg gga cca gag gcc ctg   54
                                        Met Gly Pro Glu Ala Leu
                                         1               5
 
tca tct tta ctg ctg ctg ctc ttg gtg gca agt gga gat gct gac atg   102
Ser Ser Leu Leu Leu Leu Leu Leu Val Ala Ser Gly Asp Ala Asp Met
             10                  15                  20
 
aag gga cat ttt gat cct gcc aag tgc cgc tat gcc ctg ggc atg cag   150
Lys Gly His Phe Asp Pro Ala Lys Cys Arg Tyr Ala Leu Gly Met Gln
         25                  30                  35
 
gac cgg acc atc cca gac agt gac atc tct gct tcc agc tcc tgg tca   198
Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser Ala Ser Ser Ser Trp Ser
     40                  45                  50
 
gat tcc act gcc gcc cgc cac agc agg ttg gag agc agt gac ggg gat   246
Asp Ser Thr Ala Ala Arg His Ser Arg Leu Glu Ser Ser Asp Gly Asp
 55                  60                  65                  70
 
ggg gcc tgg tgc ccc gca ggg tcg gtg ttt ccc aag gag gag gag tac   294
Gly Ala Trp Cys Pro Ala Gly Ser Val Phe Pro Lys Glu Glu Glu Tyr
                 75                  80                  85
 
ttg cag gtg gat cta caa cga ctg cac ctg gtg gct ctg gtg ggc acc   342
Leu Gln Val Asp Leu Gln Arg Leu His Leu Val Ala Leu Val Gly Thr
             90                  95                 100
 
cag gga cgg cat gcc ggg ggc ctg ggc aag gag ttc tcc cgg agc tac   390
Gln Gly Arg His Ala Gly Gly Leu Gly Lys Glu Phe Ser Arg Ser Tyr
        105                 110                 115
 
cgg ctg cgt tac tcc cgg gat ggt cgc cgc tgg atg ggc tgg aag gac   438
Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg Trp Met Gly Trp Lys Asp
    120                 125                 130
 
cgc tgg ggt cag gag gtg atc tca ggc aat gag gac cct gag gga gtg   486
Arg Trp Gly Gln Glu Val Ile Ser Gly Asn Glu Asp Pro Glu Gly Val
135                 140                 145                 150
 
gtg ctg aag gac ctt ggg ccc ccc atg gtt gcc cga ctg gtt cgc ttc   534
Val Leu Lys Asp Leu Gly Pro Pro Met Val Ala Arg Leu Val Arg Phe
                155                 160                 165
 
tac ccc cgg gct gac cgg gtc atg agc gtc tgt ctg cgg gta gag ctc   582
Tyr Pro Arg Ala Asp Arg Val Met Ser Val Cys Leu Arg Val Glu Leu
            170                 175                 180
 
tat ggc tgc ctc tgg agg gac tgc agt atg ggg gtc tgg gcc agc tgg   630
Tyr Gly Cys Leu Trp Arg Asp Cys Ser Met Gly Val Trp Ala Ser Trp
        185                 190                 195
 
cag atg gtg tgg tgg ggc tgg atg act tta gga aga gtc agg agc tgc   678
Gln Met Val Trp Trp Gly Trp Met Thr Leu Gly Arg Val Arg Ser Cys
    200                 205                 210
 
ggg tct ggc cag gct atg act atg tgg gat gga gca acc aca gct tct   726
Gly Ser Gly Gln Ala Met Thr Met Trp Asp Gly Ala Thr Thr Ala Ser
215                 220                 225                 230
 
cca gtg gct atg tgg aga tgg agt ttg agt ttg acc ggc tga           768
Pro Val Ala Met Trp Arg Trp Ser Leu Ser Leu Thr Gly  *
                235                 240
 
gggccttcca ggctatgcag                                             788

<210> 142
<211> 243
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR005A10

<400> 142
Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala
 1               5                  10                  15      
Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg
            20                  25                  30          
Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser
        35                  40                  45              
Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu
    50                  55                  60                  
Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe
65                  70                  75                  80  
Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu
                85                  90                  95      
Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys
            100                 105                 110         
Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg
        115                 120                 125             
Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn
    130                 135                 140                 
Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val
145                 150                 155                 160 
Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val
                165                 170                 175     
Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Cys Ser Met
            180                 185                 190         
Gly Val Trp Ala Ser Trp Gln Met Val Trp Trp Gly Trp Met Thr Leu
        195                 200                 205             
Gly Arg Val Arg Ser Cys Gly Ser Gly Gln Ala Met Thr Met Trp Asp
    210                 215                 220                 
Gly Ala Thr Thr Ala Ser Pro Val Ala Met Trp Arg Trp Ser Leu Ser
225                 230                 235                 240 
Leu Thr Gly
            
<210> 143
<211> 444
<212> PRT
<213> Homo sapiens

<220> 
<223> DDR1.h

<400> 143
Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala
 1               5                  10                  15      
Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg
            20                  25                  30          
Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser
        35                  40                  45              
Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu
    50                  55                  60                  
Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe
65                  70                  75                  80  
Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu
                85                  90                  95      
Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys
            100                 105                 110         
Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg
        115                 120                 125             
Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn
    130                 135                 140                 
Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val
145                 150                 155                 160 
Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val
                165                 170                 175     
Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu
            180                 185                 190         
Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val
        195                 200                 205             
Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln
    210                 215                 220                 
Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp
225                 230                 235                 240 
Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val
                245                 250                 255     
Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe
            260                 265                 270         
Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn
        275                 280                 285             
Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg
    290                 295                 300                 
Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His
305                 310                 315                 320 
Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val
                325                 330                 335     
Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Cys Pro
            340                 345                 350         
His Leu Pro Arg Thr Ala Ser Pro Ile Met Pro Arg Leu Thr Leu Leu
        355                 360                 365             
Pro Cys Arg Ala Ser Pro Gly Ala Thr Pro Met Leu Cys Leu His Cys
    370                 375                 380                 
Pro Gln Gly Gln Ser Gly Met Gly Pro Pro Glu Trp Ile Ser Leu Asp
385                 390                 395                 400 
Leu Asp Ser Ala Ser Arg Arg Ser Leu Ala Arg Ala Ser Leu Gly Arg
                405                 410                 415     
Cys Thr Cys Val Arg Ser Thr Ala Leu Lys Ile Trp Leu Val Leu Ile
            420                 425                 430         
Ser Pro Leu Met Cys Val Arg Asp Thr Leu Cys Trp
        435                 440                 


<210> 144
<211> 1683
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (20)...(1444)
<223> SR004G03

<400> 144
caggtcccgg cccggagct atg gag cgg cgc tgg ccc ctg ggg cta ggg ctg  52
                     Met Glu Arg Arg Trp Pro Leu Gly Leu Gly Leu
                      1               5                   10
 
gtg ctg ctg ctc tgc gcc ccg ctg ccc ccg ggg gcg cgc gcc aag gaa   100
Val Leu Leu Leu Cys Ala Pro Leu Pro Pro Gly Ala Arg Ala Lys Glu
             15                  20                  25
 
gtt act ctg atg gac aca agc aag gca cag gga gag ctg ggc tgg ctg   148
Val Thr Leu Met Asp Thr Ser Lys Ala Gln Gly Glu Leu Gly Trp Leu
         30                  35                  40
 
ctg gat ccc cca aaa gat ggg tgg agt gaa cag caa cag ata ctg aat   196
Leu Asp Pro Pro Lys Asp Gly Trp Ser Glu Gln Gln Gln Ile Leu Asn
     45                  50                  55
 
ggg aca ccc ctg tac atg tac cag gac tgc cca atg caa gga cgc aga   244
Gly Thr Pro Leu Tyr Met Tyr Gln Asp Cys Pro Met Gln Gly Arg Arg
 60                  65                  70                  75
 
gac act gac cac tgg ctt cgc tcc aat tgg atc tac cgc ggg gag gag   292
Asp Thr Asp His Trp Leu Arg Ser Asn Trp Ile Tyr Arg Gly Glu Glu
                 80                  85                  90
 
gct tcc cgc gtc cac gtg gag ctg cag ttc acc gtg cgg gac tgc aag   340
Ala Ser Arg Val His Val Glu Leu Gln Phe Thr Val Arg Asp Cys Lys
             95                 100                 105
 
agt ttc cct ggg gga gcc ggg cct ctg ggc tgc aag gag acc ttc aac   388
Ser Phe Pro Gly Gly Ala Gly Pro Leu Gly Cys Lys Glu Thr Phe Asn
        110                 115                 120
 
ctt ctg tac atg gag agt gac cag gat gtg ggc att cag ctc cga cgg   436
Leu Leu Tyr Met Glu Ser Asp Gln Asp Val Gly Ile Gln Leu Arg Arg
    125                 130                 135
 
ccc ttg ttc cag aag gta acc acg gtg gct gca gac cag agc ttc acc   484
Pro Leu Phe Gln Lys Val Thr Thr Val Ala Ala Asp Gln Ser Phe Thr
140                 145                 150                 155
 
att cga gac ctt gtg tct ggc tcc gtg aag ctg aat gtg gag cgc tgc   532
Ile Arg Asp Leu Val Ser Gly Ser Val Lys Leu Asn Val Glu Arg Cys
                160                 165                 170
 
tct ctg ggc cgc ctg acc cgc cgt ggc ctc tac ctc gct ttc cac aac   580
Ser Leu Gly Arg Leu Thr Arg Arg Gly Leu Tyr Leu Ala Phe His Asn
            175                 180                 185
 
ccg ggt gcc tgt gtg gcc ctg gtg tct gtc cgg gtc ttc tac cag cgc   628
Pro Gly Ala Cys Val Ala Leu Val Ser Val Arg Val Phe Tyr Gln Arg
        190                 195                 200
 
tgt cct gag acc ctg aat ggc ttg gcc caa ttc cca gac act ctg cct   676
Cys Pro Glu Thr Leu Asn Gly Leu Ala Gln Phe Pro Asp Thr Leu Pro
    205                 210                 215
 
ggc ccc gct ggg ttg gtg gaa gtg gcg ggg acc tgc ttg ccc cac gcg   724
Gly Pro Ala Gly Leu Val Glu Val Ala Gly Thr Cys Leu Pro His Ala
220                 225                 230                 235
 
cgg gcc agc ccc agg ccc tca ggt gca ccc cgc atg cac tgc agc cct   772
Arg Ala Ser Pro Arg Pro Ser Gly Ala Pro Arg Met His Cys Ser Pro
                240                 245                 250
 
gat ggc gag tgg ctg gtg cct gta gga cgg tgc cac tgt gag cct ggc   820
Asp Gly Glu Trp Leu Val Pro Val Gly Arg Cys His Cys Glu Pro Gly
            255                 260                 265
 
tat gag gaa ggt ggc agt ggc gaa gca tgt gtt gcc tgc cct agc ggc   868
Tyr Glu Glu Gly Gly Ser Gly Glu Ala Cys Val Ala Cys Pro Ser Gly
        270                 275                 280
 
tcc tac cgg atg gac atg gac aca ccc cat tgt ctc acg tgc ccc cag   916
Ser Tyr Arg Met Asp Met Asp Thr Pro His Cys Leu Thr Cys Pro Gln
    285                 290                 295
 
cag agc act gct gag tct gag ggg gcc acc atc tgt acc tgt gag agc   964
Gln Ser Thr Ala Glu Ser Glu Gly Ala Thr Ile Cys Thr Cys Glu Ser
300                 305                 310                 315
 
ggc cat tac aga gct ccc ggg gag ggc ccc cag gtg gca tgc aca ggt   1012
Gly His Tyr Arg Ala Pro Gly Glu Gly Pro Gln Val Ala Cys Thr Gly
                320                 325                 330
 
ccc ccc tcg gcc ccc cga aac ctg agc ttc tct gcc tca ggg act cag   1060
Pro Pro Ser Ala Pro Arg Asn Leu Ser Phe Ser Ala Ser Gly Thr Gln
            335                 340                 345
 
ctc tcc ctg cgt tgg gaa ccc cca gca gat acg ggg gga cgc cag gat   1108
Leu Ser Leu Arg Trp Glu Pro Pro Ala Asp Thr Gly Gly Arg Gln Asp
        350                 355                 360
 
gtc aga tac agt gtg agg tgt tcc cag tgt cag ggc aca gca cag gac   1156
Val Arg Tyr Ser Val Arg Cys Ser Gln Cys Gln Gly Thr Ala Gln Asp
    365                 370                 375
 
ggg ggg ccc tgc cag ccc tgt ggg gtg ggc gtg cac ttc tcg ccg ggg   1204
Gly Gly Pro Cys Gln Pro Cys Gly Val Gly Val His Phe Ser Pro Gly
380                 385                 390                 395
 
gcc cgg ggg ctc acc aca cct gca gtg cat gtc aat ggc ctt gaa cct   1252
Ala Arg Gly Leu Thr Thr Pro Ala Val His Val Asn Gly Leu Glu Pro
                400                 405                 410
 
tat gcc aac tac acc ttt aat gtg gaa gcc caa aat gga gtg tca ggg   1300
Tyr Ala Asn Tyr Thr Phe Asn Val Glu Ala Gln Asn Gly Val Ser Gly
            415                 420                 425
 
ctg ggc agc tct ggc cat gcc agc acc tca gtc agc atc agc atg ggg   1348
Leu Gly Ser Ser Gly His Ala Ser Thr Ser Val Ser Ile Ser Met Gly
        430                 435                 440
 
cat gca ggt gag agg ctg aga ggg gct ggg aca ggg acc tgg tgg aga   1396
His Ala Gly Glu Arg Leu Arg Gly Ala Gly Thr Gly Thr Trp Trp Arg
    445                 450                 455
 
cag aag ggc tta aga cca cag aac aaa ctg atg ggc agg aag cca tag   1444
Gln Lys Gly Leu Arg Pro Gln Asn Lys Leu Met Gly Arg Lys Pro  *
460                 465                 470
 
aaaagttact aaggttattt cctttttcct tacatatcca accttatccc tctggacccc 1504
cagagtcact gtcaggcctg tctctgagac tggtgaagaa agaaccgagg caactagagc 1564
tgacctgggc ggggtcccgg ccccgaagcc ctggggcgaa cctgacctat gagctgcacg 1624
tgctgaacca ggatgaagaa cggtaccaga tggttctaga acccagggtc ttgctgaca  1683

<210> 145
<211> 474
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR004G03

<400> 145
Met Glu Arg Arg Trp Pro Leu Gly Leu Gly Leu Val Leu Leu Leu Cys
 1               5                  10                  15      
Ala Pro Leu Pro Pro Gly Ala Arg Ala Lys Glu Val Thr Leu Met Asp
            20                  25                  30          
Thr Ser Lys Ala Gln Gly Glu Leu Gly Trp Leu Leu Asp Pro Pro Lys
        35                  40                  45              
Asp Gly Trp Ser Glu Gln Gln Gln Ile Leu Asn Gly Thr Pro Leu Tyr
    50                  55                  60                  
Met Tyr Gln Asp Cys Pro Met Gln Gly Arg Arg Asp Thr Asp His Trp
65                  70                  75                  80  
Leu Arg Ser Asn Trp Ile Tyr Arg Gly Glu Glu Ala Ser Arg Val His
                85                  90                  95      
Val Glu Leu Gln Phe Thr Val Arg Asp Cys Lys Ser Phe Pro Gly Gly
            100                 105                 110         
Ala Gly Pro Leu Gly Cys Lys Glu Thr Phe Asn Leu Leu Tyr Met Glu
        115                 120                 125             
Ser Asp Gln Asp Val Gly Ile Gln Leu Arg Arg Pro Leu Phe Gln Lys
    130                 135                 140                 
Val Thr Thr Val Ala Ala Asp Gln Ser Phe Thr Ile Arg Asp Leu Val
145                 150                 155                 160 
Ser Gly Ser Val Lys Leu Asn Val Glu Arg Cys Ser Leu Gly Arg Leu
                165                 170                 175     
Thr Arg Arg Gly Leu Tyr Leu Ala Phe His Asn Pro Gly Ala Cys Val
            180                 185                 190         
Ala Leu Val Ser Val Arg Val Phe Tyr Gln Arg Cys Pro Glu Thr Leu
        195                 200                 205             
Asn Gly Leu Ala Gln Phe Pro Asp Thr Leu Pro Gly Pro Ala Gly Leu
    210                 215                 220                 
Val Glu Val Ala Gly Thr Cys Leu Pro His Ala Arg Ala Ser Pro Arg
225                 230                 235                 240 
Pro Ser Gly Ala Pro Arg Met His Cys Ser Pro Asp Gly Glu Trp Leu
                245                 250                 255     
Val Pro Val Gly Arg Cys His Cys Glu Pro Gly Tyr Glu Glu Gly Gly
            260                 265                 270         
Ser Gly Glu Ala Cys Val Ala Cys Pro Ser Gly Ser Tyr Arg Met Asp
        275                 280                 285             
Met Asp Thr Pro His Cys Leu Thr Cys Pro Gln Gln Ser Thr Ala Glu
    290                 295                 300                 
Ser Glu Gly Ala Thr Ile Cys Thr Cys Glu Ser Gly His Tyr Arg Ala
305                 310                 315                 320 
Pro Gly Glu Gly Pro Gln Val Ala Cys Thr Gly Pro Pro Ser Ala Pro
                325                 330                 335     
Arg Asn Leu Ser Phe Ser Ala Ser Gly Thr Gln Leu Ser Leu Arg Trp
            340                 345                 350         
Glu Pro Pro Ala Asp Thr Gly Gly Arg Gln Asp Val Arg Tyr Ser Val
        355                 360                 365             
Arg Cys Ser Gln Cys Gln Gly Thr Ala Gln Asp Gly Gly Pro Cys Gln
    370                 375                 380                 
Pro Cys Gly Val Gly Val His Phe Ser Pro Gly Ala Arg Gly Leu Thr
385                 390                 395                 400 
Thr Pro Ala Val His Val Asn Gly Leu Glu Pro Tyr Ala Asn Tyr Thr
                405                 410                 415     
Phe Asn Val Glu Ala Gln Asn Gly Val Ser Gly Leu Gly Ser Ser Gly
            420                 425                 430         
His Ala Ser Thr Ser Val Ser Ile Ser Met Gly His Ala Gly Glu Arg
        435                 440                 445             
Leu Arg Gly Ala Gly Thr Gly Thr Trp Trp Arg Gln Lys Gly Leu Arg
    450                 455                 460                 
Pro Gln Asn Lys Leu Met Gly Arg Lys Pro
465                 470                 

<210> 146
<211> 1375
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (20)...(955)
<223> SR004G07

<400> 146
caggtcccgg cccggagct atg gag cgg cgc tgg ccc ctg ggg cta ggg ctg  52
                     Met Glu Arg Arg Trp Pro Leu Gly Leu Gly Leu
                      1               5                   10
 
gtg ctg ctg ctc tgc gcc ccg ctg ccc ccg ggg gcg cgc gcc aag gaa   100
Val Leu Leu Leu Cys Ala Pro Leu Pro Pro Gly Ala Arg Ala Lys Glu
             15                  20                  25
 
gtt act ctg atg gac aca agc aag gca cag gga gag ctg ggc tgg ctg   148
Val Thr Leu Met Asp Thr Ser Lys Ala Gln Gly Glu Leu Gly Trp Leu
         30                  35                  40
 
ctg gat ccc cca aaa gat ggg tgg agt gaa cag caa cag ata ctg aat   196
Leu Asp Pro Pro Lys Asp Gly Trp Ser Glu Gln Gln Gln Ile Leu Asn
     45                  50                  55
 
ggg aca ccc ctg tac atg tac cag gac tgc cca atg caa gga cgc aga   244
Gly Thr Pro Leu Tyr Met Tyr Gln Asp Cys Pro Met Gln Gly Arg Arg
 60                  65                  70                  75
 
gac act gac cac tgg ctt cgc tcc aat tgg atc tac cgc ggg gag gag   292
Asp Thr Asp His Trp Leu Arg Ser Asn Trp Ile Tyr Arg Gly Glu Glu
                 80                  85                  90
 
gct tcc cgc gtc cac gtg gag ctg cag ttc acc gtg cgg gac tgc aag   340
Ala Ser Arg Val His Val Glu Leu Gln Phe Thr Val Arg Asp Cys Lys
             95                 100                 105
 
agt ttc cct ggg gga gcc ggg cct ctg ggc tgc aag gag acc ttc aac   388
Ser Phe Pro Gly Gly Ala Gly Pro Leu Gly Cys Lys Glu Thr Phe Asn
        110                 115                 120
 
ctt ctg tac atg gag agt gac cag gat gtg ggc att cag ctc cga cgg   436
Leu Leu Tyr Met Glu Ser Asp Gln Asp Val Gly Ile Gln Leu Arg Arg
    125                 130                 135
 
ccc ttg ttc cag aag gta acc acg gtg gct gca gac cag agc ttc acc   484
Pro Leu Phe Gln Lys Val Thr Thr Val Ala Ala Asp Gln Ser Phe Thr
140                 145                 150                 155
 
att cga gac ctt gtg tct ggc tcc gtg aag ctg aat gtg gag cgc tgc   532
Ile Arg Asp Leu Val Ser Gly Ser Val Lys Leu Asn Val Glu Arg Cys
                160                 165                 170
 
tct ctg ggc cgc ctg acc cgc cgt ggc ctc tac ctc gct ttc cac aac   580
Ser Leu Gly Arg Leu Thr Arg Arg Gly Leu Tyr Leu Ala Phe His Asn
            175                 180                 185
 
ccg ggt gcc tgt gtg gcc ctg gtg tct gtc cgg gtc ttc tac cag cgc   628
Pro Gly Ala Cys Val Ala Leu Val Ser Val Arg Val Phe Tyr Gln Arg
        190                 195                 200
 
tgt cct gag acc ctg aat ggc ttg gcc caa ttc cca gac act ctg cct   676
Cys Pro Glu Thr Leu Asn Gly Leu Ala Gln Phe Pro Asp Thr Leu Pro
    205                 210                 215
 
ggc ccc gct ggg ttg gtg gaa gtg gcg ggg acc tgc ttg ccc cac gcg   724
Gly Pro Ala Gly Leu Val Glu Val Ala Gly Thr Cys Leu Pro His Ala
220                 225                 230                 235
 
cgg gcc agc ccc agg ccc tca ggt gca ccc cgc atg cac tgc agc cct   772
Arg Ala Ser Pro Arg Pro Ser Gly Ala Pro Arg Met His Cys Ser Pro
                240                 245                 250
 
gat ggc gag tgg ctg gtg cct gta gga cgg tgc cac tgt gag cct ggc   820
Asp Gly Glu Trp Leu Val Pro Val Gly Arg Cys His Cys Glu Pro Gly
            255                 260                 265
 
tat gag gaa ggt ggc agt ggc gaa gca tgt gtt ggt aag aac gga ggc   868
Tyr Glu Glu Gly Gly Ser Gly Glu Ala Cys Val Gly Lys Asn Gly Gly
        270                 275                 280
 
ggt gag aac ctg agg aac cac tcg gga gga ttg cag gag tac ccc ggc   916
Gly Glu Asn Leu Arg Asn His Ser Gly Gly Leu Gln Glu Tyr Pro Gly
    285                 290                 295
 
aga gaa gga ggc cag tgc tcc gcc tca gtg ggt ttt taa cctgagtgtc    965
Arg Glu Gly Gly Gln Cys Ser Ala Ser Val Gly Phe  *
300                 305                 310
 
ccagagcagc ggacacacac atgcagagat gtttccagta gaagggattg gggcaggaag 1025
gggtggtggt ggttctgcct gtaaaaacat ttacagaacc actgctctgc tgcgttctct 1085
ctccagcctg ccctagcggc tcctaccgga tggacatgga cacaccccat tgtctcacgt 1145
gcccccagca gagcactgct gagtctgagg gggccaccat ctgtacctgt gagagcggcc 1205
attacagagc tcccggggag ggcccccagg tggcatgcac agagtcactg tcaggcctgt 1265
ctctgagact ggtgaagaaa gaaccgaggc aactagagct gacctgggcg gggtcccggc 1325
cccgaagccc tggggcgaac ctgacctatg agctgcacgt gctgaaccag            1375

<210> 147
<211> 311
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR004G07

<400> 147
Met Glu Arg Arg Trp Pro Leu Gly Leu Gly Leu Val Leu Leu Leu Cys
 1               5                  10                  15      
Ala Pro Leu Pro Pro Gly Ala Arg Ala Lys Glu Val Thr Leu Met Asp
            20                  25                  30          
Thr Ser Lys Ala Gln Gly Glu Leu Gly Trp Leu Leu Asp Pro Pro Lys
        35                  40                  45              
Asp Gly Trp Ser Glu Gln Gln Gln Ile Leu Asn Gly Thr Pro Leu Tyr
    50                  55                  60                  
Met Tyr Gln Asp Cys Pro Met Gln Gly Arg Arg Asp Thr Asp His Trp
65                  70                  75                  80  
Leu Arg Ser Asn Trp Ile Tyr Arg Gly Glu Glu Ala Ser Arg Val His
                85                  90                  95      
Val Glu Leu Gln Phe Thr Val Arg Asp Cys Lys Ser Phe Pro Gly Gly
            100                 105                 110         
Ala Gly Pro Leu Gly Cys Lys Glu Thr Phe Asn Leu Leu Tyr Met Glu
        115                 120                 125             
Ser Asp Gln Asp Val Gly Ile Gln Leu Arg Arg Pro Leu Phe Gln Lys
    130                 135                 140                 
Val Thr Thr Val Ala Ala Asp Gln Ser Phe Thr Ile Arg Asp Leu Val
145                 150                 155                 160 
Ser Gly Ser Val Lys Leu Asn Val Glu Arg Cys Ser Leu Gly Arg Leu
                165                 170                 175     
Thr Arg Arg Gly Leu Tyr Leu Ala Phe His Asn Pro Gly Ala Cys Val
            180                 185                 190         
Ala Leu Val Ser Val Arg Val Phe Tyr Gln Arg Cys Pro Glu Thr Leu
        195                 200                 205             
Asn Gly Leu Ala Gln Phe Pro Asp Thr Leu Pro Gly Pro Ala Gly Leu
    210                 215                 220                 
Val Glu Val Ala Gly Thr Cys Leu Pro His Ala Arg Ala Ser Pro Arg
225                 230                 235                 240 
Pro Ser Gly Ala Pro Arg Met His Cys Ser Pro Asp Gly Glu Trp Leu
                245                 250                 255     
Val Pro Val Gly Arg Cys His Cys Glu Pro Gly Tyr Glu Glu Gly Gly
            260                 265                 270         
Ser Gly Glu Ala Cys Val Gly Lys Asn Gly Gly Gly Glu Asn Leu Arg
        275                 280                 285             
Asn His Ser Gly Gly Leu Gln Glu Tyr Pro Gly Arg Glu Gly Gly Gln
    290                 295                 300                 
Cys Ser Ala Ser Val Gly Phe
305                 310     


<210> 148
<211> 1511
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (20)...(1492)
<223> SR004H03

<400> 148
caggtcccgg cccggagct atg gag cgg cgc tgg ccc ctg ggg cta ggg ctg  52
                     Met Glu Arg Arg Trp Pro Leu Gly Leu Gly Leu
                      1               5                   10
 
gtg ctg ctg ctc tgc gcc ccg ctg ccc ccg ggg gcg cgc gcc aag gaa   100
Val Leu Leu Leu Cys Ala Pro Leu Pro Pro Gly Ala Arg Ala Lys Glu
             15                  20                  25
 
gtt act ctg atg gac aca agc aag gca cag gga gag ctg ggc tgg ctg   148
Val Thr Leu Met Asp Thr Ser Lys Ala Gln Gly Glu Leu Gly Trp Leu
         30                  35                  40
 
ctg gat ccc cca aaa gat ggg tgg agt gaa cag caa cag ata ctg aat   196
Leu Asp Pro Pro Lys Asp Gly Trp Ser Glu Gln Gln Gln Ile Leu Asn
     45                  50                  55
 
ggg aca ccc ctg tac atg tac cag gac tgc cca atg caa gga cgc aga   244
Gly Thr Pro Leu Tyr Met Tyr Gln Asp Cys Pro Met Gln Gly Arg Arg
 60                  65                  70                  75
 
gac act gac cac tgg ctt cgc tcc aat tgg atc tac cgc ggg gag gag   292
Asp Thr Asp His Trp Leu Arg Ser Asn Trp Ile Tyr Arg Gly Glu Glu
                 80                  85                  90
 
gct tcc cgc gtc cac gtg gag ctg cag ttc acc gtg cgg gac tgc aag   340
Ala Ser Arg Val His Val Glu Leu Gln Phe Thr Val Arg Asp Cys Lys
             95                 100                 105
 
agt ttc cct ggg gga gcc ggg cct ctg ggc tgc aag gag acc ttc aac   388
Ser Phe Pro Gly Gly Ala Gly Pro Leu Gly Cys Lys Glu Thr Phe Asn
        110                 115                 120
 
ctt ctg tac atg gag agt gac cag gat gtg ggc att cag ctc cga cgg   436
Leu Leu Tyr Met Glu Ser Asp Gln Asp Val Gly Ile Gln Leu Arg Arg
    125                 130                 135
 
ccc ttg ttc cag aag gta acc acg gtg gct gca gac cag agc ttc acc   484
Pro Leu Phe Gln Lys Val Thr Thr Val Ala Ala Asp Gln Ser Phe Thr
140                 145                 150                 155
 
att cga gac ctt gtg tct ggc tcc gtg aag ctg aat gtg gag cgc tgc   532
Ile Arg Asp Leu Val Ser Gly Ser Val Lys Leu Asn Val Glu Arg Cys
                160                 165                 170
 
tct ctg ggc cgc ctg acc cgc cgt ggc ctc tac ctc gct ttc cac aac   580
Ser Leu Gly Arg Leu Thr Arg Arg Gly Leu Tyr Leu Ala Phe His Asn
            175                 180                 185
 
ccg ggt gcc tgt gtg gcc ctg gtg tct gtc cgg gtc ttc tac cag cgc   628
Pro Gly Ala Cys Val Ala Leu Val Ser Val Arg Val Phe Tyr Gln Arg
        190                 195                 200
 
tgt cct gag acc ctg aat ggc ttg gcc caa ttc cca gac act ctg cct   676
Cys Pro Glu Thr Leu Asn Gly Leu Ala Gln Phe Pro Asp Thr Leu Pro
    205                 210                 215
 
ggc ccc gct ggg ttg gtg gaa gtg gcg ggg acc tgc ttg ccc cac gcg   724
Gly Pro Ala Gly Leu Val Glu Val Ala Gly Thr Cys Leu Pro His Ala
220                 225                 230                 235
 
cgg gcc agc ccc agg ccc tca ggt gca ccc cgc atg cac tgc agc cct   772
Arg Ala Ser Pro Arg Pro Ser Gly Ala Pro Arg Met His Cys Ser Pro
                240                 245                 250
 
gat ggc gag tgg ctg gtg cct gta gga cgg tgc cac tgt gag cct ggc   820
Asp Gly Glu Trp Leu Val Pro Val Gly Arg Cys His Cys Glu Pro Gly
            255                 260                 265
 
tat gag gaa ggt ggc agt ggc gaa gca tgt gtt gcc tgc cct agc ggc   868
Tyr Glu Glu Gly Gly Ser Gly Glu Ala Cys Val Ala Cys Pro Ser Gly
        270                 275                 280
 
tcc tac cgg atg gac atg gac aca ccc cat tgt ctc acg tgc ccc cag   916
Ser Tyr Arg Met Asp Met Asp Thr Pro His Cys Leu Thr Cys Pro Gln
    285                 290                 295
 
cag agc act gct gag tct gag ggg gcc acc atc tgt acc tgt gag agc   964
Gln Ser Thr Ala Glu Ser Glu Gly Ala Thr Ile Cys Thr Cys Glu Ser
300                 305                 310                 315
 
ggc cat tac aga gct ccc ggg gag ggc ccc cag gtg gca tgc aca ggt   1012
Gly His Tyr Arg Ala Pro Gly Glu Gly Pro Gln Val Ala Cys Thr Gly
                320                 325                 330
 
ccc ccc tcg gcc ccc cga aac ctg agc ttc tct gcc tca ggg act cag   1060
Pro Pro Ser Ala Pro Arg Asn Leu Ser Phe Ser Ala Ser Gly Thr Gln
            335                 340                 345
 
ctc tcc ctg cgt tgg gaa ccc cca gca gat acg ggg gga cgc cag gat   1108
Leu Ser Leu Arg Trp Glu Pro Pro Ala Asp Thr Gly Gly Arg Gln Asp
        350                 355                 360
 
gtc aga tac agt gtg agg tgt tcc cag tgt cag ggc aca gca cag gac   1156
Val Arg Tyr Ser Val Arg Cys Ser Gln Cys Gln Gly Thr Ala Gln Asp
    365                 370                 375
 
ggg ggg ccc tgc cag ccc tgt ggg gtg ggc gtg cac ttc tcg ccg ggg   1204
Gly Gly Pro Cys Gln Pro Cys Gly Val Gly Val His Phe Ser Pro Gly
380                 385                 390                 395
 
gcc cgg ggg ctc acc aca cct gca gtg cat gtc aat ggc ctt gaa cct   1252
Ala Arg Gly Leu Thr Thr Pro Ala Val His Val Asn Gly Leu Glu Pro
                400                 405                 410
 
tat gcc aac tac acc ttt aat gtg gaa gcc caa aat gga gtg tca ggg   1300
Tyr Ala Asn Tyr Thr Phe Asn Val Glu Ala Gln Asn Gly Val Ser Gly
            415                 420                 425
 
ctg ggc agc tct ggc cat gcc agc acc tca gtc agc atc agc atg ggg   1348
Leu Gly Ser Ser Gly His Ala Ser Thr Ser Val Ser Ile Ser Met Gly
        430                 435                 440
 
cat gca gat cca acc tta tcc ctc tgg acc ccc aga gtc act gtc agg   1396
His Ala Asp Pro Thr Leu Ser Leu Trp Thr Pro Arg Val Thr Val Arg
    445                 450                 455
 
cct gtc tct gag act ggt gaa gaa aga acc gag gca act aga gct gac   1444
Pro Val Ser Glu Thr Gly Glu Glu Arg Thr Glu Ala Thr Arg Ala Asp
460                 465                 470                 475
 
ctg ggc ggg gtc ccg gcc ccg aag ccc tgg ggc gaa cct gac cta tga   1492
Leu Gly Gly Val Pro Ala Pro Lys Pro Trp Gly Glu Pro Asp Leu  *
                480                 485                 490
 
gctgcacgtg ctgaaccag                                              1511

<210> 149
<211> 490
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR004H03

<400> 149
Met Glu Arg Arg Trp Pro Leu Gly Leu Gly Leu Val Leu Leu Leu Cys
 1               5                  10                  15      
Ala Pro Leu Pro Pro Gly Ala Arg Ala Lys Glu Val Thr Leu Met Asp
            20                  25                  30          
Thr Ser Lys Ala Gln Gly Glu Leu Gly Trp Leu Leu Asp Pro Pro Lys
        35                  40                  45              
Asp Gly Trp Ser Glu Gln Gln Gln Ile Leu Asn Gly Thr Pro Leu Tyr
    50                  55                  60                  
Met Tyr Gln Asp Cys Pro Met Gln Gly Arg Arg Asp Thr Asp His Trp
65                  70                  75                  80  
Leu Arg Ser Asn Trp Ile Tyr Arg Gly Glu Glu Ala Ser Arg Val His
                85                  90                  95      
Val Glu Leu Gln Phe Thr Val Arg Asp Cys Lys Ser Phe Pro Gly Gly
            100                 105                 110         
Ala Gly Pro Leu Gly Cys Lys Glu Thr Phe Asn Leu Leu Tyr Met Glu
        115                 120                 125             
Ser Asp Gln Asp Val Gly Ile Gln Leu Arg Arg Pro Leu Phe Gln Lys
    130                 135                 140                 
Val Thr Thr Val Ala Ala Asp Gln Ser Phe Thr Ile Arg Asp Leu Val
145                 150                 155                 160 
Ser Gly Ser Val Lys Leu Asn Val Glu Arg Cys Ser Leu Gly Arg Leu
                165                 170                 175     
Thr Arg Arg Gly Leu Tyr Leu Ala Phe His Asn Pro Gly Ala Cys Val
            180                 185                 190         
Ala Leu Val Ser Val Arg Val Phe Tyr Gln Arg Cys Pro Glu Thr Leu
        195                 200                 205             
Asn Gly Leu Ala Gln Phe Pro Asp Thr Leu Pro Gly Pro Ala Gly Leu
    210                 215                 220                 
Val Glu Val Ala Gly Thr Cys Leu Pro His Ala Arg Ala Ser Pro Arg
225                 230                 235                 240 
Pro Ser Gly Ala Pro Arg Met His Cys Ser Pro Asp Gly Glu Trp Leu
                245                 250                 255     
Val Pro Val Gly Arg Cys His Cys Glu Pro Gly Tyr Glu Glu Gly Gly
            260                 265                 270         
Ser Gly Glu Ala Cys Val Ala Cys Pro Ser Gly Ser Tyr Arg Met Asp
        275                 280                 285             
Met Asp Thr Pro His Cys Leu Thr Cys Pro Gln Gln Ser Thr Ala Glu
    290                 295                 300                 
Ser Glu Gly Ala Thr Ile Cys Thr Cys Glu Ser Gly His Tyr Arg Ala
305                 310                 315                 320 
Pro Gly Glu Gly Pro Gln Val Ala Cys Thr Gly Pro Pro Ser Ala Pro
                325                 330                 335     
Arg Asn Leu Ser Phe Ser Ala Ser Gly Thr Gln Leu Ser Leu Arg Trp
            340                 345                 350         
Glu Pro Pro Ala Asp Thr Gly Gly Arg Gln Asp Val Arg Tyr Ser Val
        355                 360                 365             
Arg Cys Ser Gln Cys Gln Gly Thr Ala Gln Asp Gly Gly Pro Cys Gln
    370                 375                 380                 
Pro Cys Gly Val Gly Val His Phe Ser Pro Gly Ala Arg Gly Leu Thr
385                 390                 395                 400 
Thr Pro Ala Val His Val Asn Gly Leu Glu Pro Tyr Ala Asn Tyr Thr
                405                 410                 415     
Phe Asn Val Glu Ala Gln Asn Gly Val Ser Gly Leu Gly Ser Ser Gly
            420                 425                 430         
His Ala Ser Thr Ser Val Ser Ile Ser Met Gly His Ala Asp Pro Thr
        435                 440                 445             
Leu Ser Leu Trp Thr Pro Arg Val Thr Val Arg Pro Val Ser Glu Thr
    450                 455                 460                 
Gly Glu Glu Arg Thr Glu Ala Thr Arg Ala Asp Leu Gly Gly Val Pro
465                 470                 475                 480 
Ala Pro Lys Pro Trp Gly Glu Pro Asp Leu
                485                 490 

<210> 150
<211> 166
<212> PRT
<213> Homo sapiens

<220> 
<223> EPHA1.b

<400> 150
Met Asp Thr Ser Lys Ala Gln Gly Glu Leu Gly Trp Leu Leu Asp Pro
 1               5                  10                  15      
Pro Lys Asp Gly Trp Ser Glu Gln Gln Gln Ile Leu Asn Gly Thr Pro
            20                  25                  30          
Leu Tyr Met Tyr Gln Asp Cys Pro Met Gln Gly Arg Arg Asp Thr Asp
        35                  40                  45              
His Trp Leu Arg Ser Asn Trp Ile Tyr Arg Gly Glu Glu Ala Ser Arg
    50                  55                  60                  
Val His Val Glu Leu Gln Phe Thr Val Arg Asp Cys Lys Ser Phe Pro
65                  70                  75                  80  
Gly Gly Ala Gly Pro Leu Gly Cys Lys Glu Thr Phe Asn Leu Leu Tyr
                85                  90                  95      
Met Glu Ser Asp Gln Asp Val Gly Ile Gln Leu Arg Arg Pro Leu Phe
            100                 105                 110         
Gln Lys Val Leu Leu Pro Ser Met Pro Ser Gly Ser Trp Cys Arg Ser
        115                 120                 125             
Leu Val Ala Pro Tyr Trp Val Pro Glu Lys Val Ala Glu Thr Gly Arg
    130                 135                 140                 
Gly Cys Arg Gly Arg Ile Leu Lys Arg Ile Trp Arg Leu Lys Ala Gly
145                 150                 155                 160 
His Gly Gly Leu Cys Leu
                165     

<210> 151
<211> 1721
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR016E12

<400> 151
ctctctggct actagagacc cactgcttac tggcttatcg aaattaatac gactcactat 60
agggagaccc aagctggcta gttaagcttg gtaccgagct cggatccacc atggagctcc 120
aggcagcccg cgcctgcttc gccctgctgt ggggctgtgc gctggccgcg gccgcggcgg 180
cgcagggcaa ggaagtggta ctgctggact ttgctgcagc tggaggggag ctcggctggc 240
tcacacaccc gtatggcaaa gggtgggacc tgatgcagaa catcatgaat gacatgccga 300
tctacatgta ctccgtgtgc aacgtgatgt ctggcgacca ggacaactgg ctccgcacca 360
actgggtgta ccgaggagag gctgagcgta tcttcattga gctcaagttt actgtacgtg 420
actgcaacag cttccctggt ggcgccagct cctgcaagga gactttcaac ctctactatg 480
ccgagtcgga cctggactac ggcaccaact tccagaagcg cctgttcacc aagattgaca 540
ccattgcgcc cgatgagatc accgtcagca gcgacttcga ggcacgccac gtgaagctga 600
acgtggagga gcgctccgtg gggccgctca cccgcaaagg cttctacctg gccttccagg 660
atatcggtgc ctgtgtggca ctactctccg tccgtgtcta ctacgagaag tgccccgagc 720
cgctgcaggg cctggcccac ttccctgaga ccatcgccgg ctctgatgca ccttccctgg 780
ccactgtggc cggcacctgt gtggaccatg ccgtggtgcc accggggggt gaagagcccc 840
gtatgcactg tgcagtggat ggcgagtggc tggtgcccat tgggcagtgc ctgtgccagg 900
caggctacga gaaggtggag gatgcctgcc aggcctgctc gcctggattt tttaagtttg 960
aggcatccga gagcccctgc ttggagtgcc ctgagcgcac gctgccatcc cctgagggtg 1020
ccacctcctg cgagtgtgag gaaggcttct tccgggcacc tcaggaccca gcgtcgatgc 1080
cttgcacacg acccccttcc gccccacact acctcacagc cgtgggcatg ggtgccaagg 1140
tggagctgcg ctggacgccc cctcaggaca gcgggggccg cgaggacatt gtctacagcg 1200
tcacctgcga acagtgctgg cccgagtctg gggaatgcgg gccgtgtgag gccagtgtgc 1260
gctactcgga gcctcctcac ggactgaccc gcaccagtgt gacagtgagc gacctggagc 1320
cccacatgaa ctacaccttc accgtggagg cccgcaatgg cgtctcaggc ctggtaacca 1380
gccgcagctt ccgtactgcc agtgtcagca tcaaccagac agagcccccc aaggtgaggc 1440
tggagggccg cagcaccacc tcgcttagcg tctcctggag catccccccg ccgcagcaga 1500
gccgagtgtg gaagtacgag gtcacttacc gcaagaaggt aactcccaga ggggcggggc 1560
tggctctagc tgggccgaca gcaggggaca ggctggtcac actcgagtct agagggccct 1620
tcgaacaaaa actcatctca gaagaggatc tgaatatgca taccggtcat catcaccatc 1680
accattgagt ttaaacccgc tgatcagcct cgactgtgcc t                     1721

<210> 152
<211> 497
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR016E12

<400> 152
Met Glu Leu Gln Ala Ala Arg Ala Cys Phe Ala Leu Leu Trp Gly Cys
 1               5                  10                  15      
Ala Leu Ala Ala Ala Ala Ala Ala Gln Gly Lys Glu Val Val Leu Leu
            20                  25                  30          
Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly Trp Leu Thr His Pro Tyr
        35                  40                  45              
Gly Lys Gly Trp Asp Leu Met Gln Asn Ile Met Asn Asp Met Pro Ile
    50                  55                  60                  
Tyr Met Tyr Ser Val Cys Asn Val Met Ser Gly Asp Gln Asp Asn Trp
65                  70                  75                  80  
Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu Ala Glu Arg Ile Phe Ile
                85                  90                  95      
Glu Leu Lys Phe Thr Val Arg Asp Cys Asn Ser Phe Pro Gly Gly Ala
            100                 105                 110         
Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Ala Glu Ser Asp Leu
        115                 120                 125             
Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu Phe Thr Lys Ile Asp Thr
    130                 135                 140                 
Ile Ala Pro Asp Glu Ile Thr Val Ser Ser Asp Phe Glu Ala Arg His
145                 150                 155                 160 
Val Lys Leu Asn Val Glu Glu Arg Ser Val Gly Pro Leu Thr Arg Lys
                165                 170                 175     
Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Val Ala Leu Leu
            180                 185                 190         
Ser Val Arg Val Tyr Tyr Glu Lys Cys Pro Glu Pro Leu Gln Gly Leu
        195                 200                 205             
Ala His Phe Pro Glu Thr Ile Ala Gly Ser Asp Ala Pro Ser Leu Ala
    210                 215                 220                 
Thr Val Ala Gly Thr Cys Val Asp His Ala Val Val Pro Pro Gly Gly
225                 230                 235                 240 
Glu Glu Pro Arg Met His Cys Ala Val Asp Gly Glu Trp Leu Val Pro
                245                 250                 255     
Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr Glu Lys Val Glu Asp Ala
            260                 265                 270         
Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys Phe Glu Ala Ser Glu Ser
        275                 280                 285             
Pro Cys Leu Glu Cys Pro Glu Arg Thr Leu Pro Ser Pro Glu Gly Ala
    290                 295                 300                 
Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe Arg Ala Pro Gln Asp Pro
305                 310                 315                 320 
Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro His Tyr Leu Thr
                325                 330                 335     
Ala Val Gly Met Gly Ala Lys Val Glu Leu Arg Trp Thr Pro Pro Gln
            340                 345                 350         
Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr Ser Val Thr Cys Glu Gln
        355                 360                 365             
Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro Cys Glu Ala Ser Val Arg
    370                 375                 380                 
Tyr Ser Glu Pro Pro His Gly Leu Thr Arg Thr Ser Val Thr Val Ser
385                 390                 395                 400 
Asp Leu Glu Pro His Met Asn Tyr Thr Phe Thr Val Glu Ala Arg Asn
                405                 410                 415     
Gly Val Ser Gly Leu Val Thr Ser Arg Ser Phe Arg Thr Ala Ser Val
            420                 425                 430         
Ser Ile Asn Gln Thr Glu Pro Pro Lys Val Arg Leu Glu Gly Arg Ser
        435                 440                 445             
Thr Thr Ser Leu Ser Val Ser Trp Ser Ile Pro Pro Pro Gln Gln Ser
    450                 455                 460                 
Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg Lys Lys Val Thr Pro Arg
465                 470                 475                 480 
Gly Ala Gly Leu Ala Leu Ala Gly Pro Thr Ala Gly Asp Arg Leu Val
                485                 490                 495     
Thr

<210> 153
<211> 495
<212> PRT
<213> Homo Sapiens

<220> 
<223> EPHA8.b

<400> 153
Met Ala Pro Ala Arg Gly Arg Leu Pro Pro Ala Leu Trp Val Val Thr
 1               5                  10                  15      
Ala Ala Ala Ala Ala Ala Thr Cys Val Ser Ala Ala Arg Gly Glu Val
            20                  25                  30          
Asn Leu Leu Asp Thr Ser Thr Ile His Gly Asp Trp Gly Trp Leu Thr
        35                  40                  45              
Tyr Pro Ala His Gly Trp Asp Ser Ile Asn Glu Val Asp Glu Ser Phe
    50                  55                  60                  
Gln Pro Ile His Thr Tyr Gln Val Cys Asn Val Met Ser Pro Asn Gln
65                  70                  75                  80  
Asn Asn Trp Leu Arg Thr Ser Trp Val Pro Arg Asp Gly Ala Arg Arg
                85                  90                  95      
Val Tyr Ala Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Met Pro
            100                 105                 110         
Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Leu Glu
        115                 120                 125             
Ser Asp Arg Asp Leu Gly Ala Ser Thr Gln Glu Ser Gln Phe Leu Lys
    130                 135                 140                 
Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gly Ala Asp Leu Gly
145                 150                 155                 160 
Val Arg Arg Leu Lys Leu Asn Thr Glu Val Arg Ser Val Gly Pro Leu
                165                 170                 175     
Ser Lys Arg Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Leu
            180                 185                 190         
Ala Ile Leu Ser Leu Arg Ile Tyr Tyr Lys Lys Cys Pro Ala Met Val
        195                 200                 205             
Arg Asn Leu Ala Ala Phe Ser Glu Ala Val Thr Gly Ala Asp Ser Ser
    210                 215                 220                 
Ser Leu Val Glu Val Arg Gly Gln Cys Val Arg His Ser Glu Glu Arg
225                 230                 235                 240 
Asp Thr Pro Lys Met Tyr Cys Ser Ala Glu Gly Glu Trp Leu Val Pro
                245                 250                 255     
Ile Gly Lys Cys Val Cys Ser Ala Gly Tyr Glu Glu Arg Arg Asp Ala
            260                 265                 270         
Cys Val Ala Cys Glu Leu Gly Phe Tyr Lys Ser Ala Pro Gly Asp Gln
        275                 280                 285             
Leu Cys Ala Arg Cys Pro Pro His Ser His Ser Ala Ala Pro Ala Ala
    290                 295                 300                 
Gln Ala Cys His Cys Asp Leu Ser Tyr Tyr Arg Ala Ala Leu Asp Pro
305                 310                 315                 320 
Pro Ser Ser Ala Cys Thr Arg Pro Pro Ser Ala Pro Val Asn Leu Ile
                325                 330                 335     
Ser Ser Val Asn Gly Thr Ser Val Thr Leu Glu Trp Ala Pro Pro Leu
            340                 345                 350         
Asp Pro Gly Gly Arg Ser Asp Ile Thr Tyr Asn Ala Val Cys Arg Arg
        355                 360                 365             
Cys Pro Trp Ala Leu Ser Arg Cys Glu Ala Cys Gly Ser Gly Thr Arg
    370                 375                 380                 
Phe Val Pro Gln Gln Thr Ser Leu Val Gln Ala Ser Leu Leu Val Ala
385                 390                 395                 400 
Asn Leu Leu Ala His Met Asn Tyr Ser Phe Trp Ile Glu Ala Val Asn
                405                 410                 415     
Gly Val Ser Asp Leu Ser Pro Glu Pro Arg Arg Ala Ala Val Val Asn
            420                 425                 430         
Ile Thr Thr Asn Gln Ala Gly Arg Arg Arg Asn Ser Val Pro Gln Arg
        435                 440                 445             
Pro Gly Pro Pro Ala Ser Pro Ala Ser Asp Pro Ser Arg Asp Gln Ser
    450                 455                 460                 
Ser Ala Gly Asp Val Leu Trp Ala Phe Arg Gln Val Pro Leu Trp Pro
465                 470                 475                 480 
Cys Ala Pro His Gln Asp Pro Glu Leu Glu Ala Leu His Cys Leu
                485                 490                 495 


<210> 154
<211> 1107
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (20)...(748)
<223> SR005D06

<400> 154
tgcgggccgt cggccggcg atg gcc ctg gat tat cta cta ctg ctc ctc ctg  52
                     Met Ala Leu Asp Tyr Leu Leu Leu Leu Leu Leu
                      1               5                   10
 
gca tcc gca gtg gct gcg atg gaa gaa acg tta atg gac acc aga acg   100
Ala Ser Ala Val Ala Ala Met Glu Glu Thr Leu Met Asp Thr Arg Thr
             15                  20                  25
 
gct act gca gag ctg ggc tgg acg gcc aat cct gcg tcc ggg tgg gaa   148
Ala Thr Ala Glu Leu Gly Trp Thr Ala Asn Pro Ala Ser Gly Trp Glu
         30                  35                  40
 
gaa gtc agt ggc tac gat gaa aac ctg aac acc atc cgc acc tac cag   196
Glu Val Ser Gly Tyr Asp Glu Asn Leu Asn Thr Ile Arg Thr Tyr Gln
     45                  50                  55
 
gtg tgc aat gtc ttc gag ccc aac cag aac aat tgg ctg ctc acc acc   244
Val Cys Asn Val Phe Glu Pro Asn Gln Asn Asn Trp Leu Leu Thr Thr
 60                  65                  70                  75
 
ttc atc aac cgg cgg ggg gcc cat cgc atc tac aca gag atg cgc ttc   292
Phe Ile Asn Arg Arg Gly Ala His Arg Ile Tyr Thr Glu Met Arg Phe
                 80                  85                  90
 
act gtg aga gac tgc agc agc ctc cct aat gtc cca gga tcc tgc aag   340
Thr Val Arg Asp Cys Ser Ser Leu Pro Asn Val Pro Gly Ser Cys Lys
             95                 100                 105
 
gag acc ttc aac ttg tat tac tat gag act gac tct gtc att gcc acc   388
Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu Thr Asp Ser Val Ile Ala Thr
        110                 115                 120
 
aag aag tca gcc ttc tgg tct gag gcc ccc tac ctc aaa gta gac acc   436
Lys Lys Ser Ala Phe Trp Ser Glu Ala Pro Tyr Leu Lys Val Asp Thr
    125                 130                 135
 
att gct gca gat gag agc ttc tcc cag gtg gac ttt ggg gga agg ctg   484
Ile Ala Ala Asp Glu Ser Phe Ser Gln Val Asp Phe Gly Gly Arg Leu
140                 145                 150                 155
 
atg aag ctt gcc ctg cag gga cat tca agg cca gcc agg aag ctg aag   532
Met Lys Leu Ala Leu Gln Gly His Ser Arg Pro Ala Arg Lys Leu Lys
                160                 165                 170
 
gct gct ccc act gcc cct cca aca gcc gct ccc ctg cag agg cgt ctc   580
Ala Ala Pro Thr Ala Pro Pro Thr Ala Ala Pro Leu Gln Arg Arg Leu
            175                 180                 185
 
cca tct gca cct gtc gga ccg gtt att acc gag cgg act ttg acc ctc   628
Pro Ser Ala Pro Val Gly Pro Val Ile Thr Glu Arg Thr Leu Thr Leu
        190                 195                 200
 
cag aag tgg cat gca cta gcg tcc cat cag gtc ccc gca atg tta tct   676
Gln Lys Trp His Ala Leu Ala Ser His Gln Val Pro Ala Met Leu Ser
    205                 210                 215
 
cca tcg tca atg aga cgt cca tca ttc tgg agt ggc acc ctc caa ggg   724
Pro Ser Ser Met Arg Arg Pro Ser Phe Trp Ser Gly Thr Leu Gln Gly
220                 225                 230                 235
 
aga cag gtg ggc ggg atg atg tga cctacaacat catctgcaaa aagtgccggg  778
Arg Gln Val Gly Gly Met Met  *
                240
 
cagaccgccg gagctgctcc cgctgtgacg acaatgtgga gtttgtgccc aggcagctgg 838
gcctgacgga gtgccgcgtc tccatcagca gcctgtgggc ccacaccccc tacacctttg 898
acatccaggc catcaatgga gtctccagca agagtccctt ccccccacag cacgtctctg 958
tcaacatcac cacaaaccaa gccgccccct ccaccgttcc catcatgcac caagtcagtg 1018
ccactatgag gagcatcacc ttgtcatggc cacagccgga gcagcccaat ggcatcatcc 1078
tggactatga gatccggtac tatgagaag                                   1107

<210> 155
<211> 242
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR005D06

<400> 155
Met Ala Leu Asp Tyr Leu Leu Leu Leu Leu Leu Ala Ser Ala Val Ala
 1               5                  10                  15      
Ala Met Glu Glu Thr Leu Met Asp Thr Arg Thr Ala Thr Ala Glu Leu
            20                  25                  30          
Gly Trp Thr Ala Asn Pro Ala Ser Gly Trp Glu Glu Val Ser Gly Tyr
        35                  40                  45              
Asp Glu Asn Leu Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val Phe
    50                  55                  60                  
Glu Pro Asn Gln Asn Asn Trp Leu Leu Thr Thr Phe Ile Asn Arg Arg
65                  70                  75                  80  
Gly Ala His Arg Ile Tyr Thr Glu Met Arg Phe Thr Val Arg Asp Cys
                85                  90                  95      
Ser Ser Leu Pro Asn Val Pro Gly Ser Cys Lys Glu Thr Phe Asn Leu
            100                 105                 110         
Tyr Tyr Tyr Glu Thr Asp Ser Val Ile Ala Thr Lys Lys Ser Ala Phe
        115                 120                 125             
Trp Ser Glu Ala Pro Tyr Leu Lys Val Asp Thr Ile Ala Ala Asp Glu
    130                 135                 140                 
Ser Phe Ser Gln Val Asp Phe Gly Gly Arg Leu Met Lys Leu Ala Leu
145                 150                 155                 160 
Gln Gly His Ser Arg Pro Ala Arg Lys Leu Lys Ala Ala Pro Thr Ala
                165                 170                 175     
Pro Pro Thr Ala Ala Pro Leu Gln Arg Arg Leu Pro Ser Ala Pro Val
            180                 185                 190         
Gly Pro Val Ile Thr Glu Arg Thr Leu Thr Leu Gln Lys Trp His Ala
        195                 200                 205             
Leu Ala Ser His Gln Val Pro Ala Met Leu Ser Pro Ser Ser Met Arg
    210                 215                 220                 
Arg Pro Ser Phe Trp Ser Gly Thr Leu Gln Gly Arg Gln Val Gly Gly
225                 230                 235                 240 
Met Met


<210> 156
<211> 1353
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR012C08

<400> 156
agtcccgcgc ggagtatcgg cgtccacccg cccagggaga gtcagacctg ggggggcgag 60
ggccccccaa actcagttcg gatcctaccc gagtgaggcg gcgccatgga gctccgggtg 120
ctgctctgct gggcttcgtt ggccgcagct ttggaagaga ccctgctgaa cacaaaattg 180
gaaactgctg atctgaagtg ggtgacattc cctcaggtgg acgggcagtg ggaggaactg 240
agcggcctgg atgaggaaca gcacagcgtg cgcacctacg aagtgtgtga cgtgcagcgt 300
gccccgggcc aggcccactg gcttcgcaca ggttgggtcc cacggcgggg cgccgtccac 360
gtgtacgcca cgctgcgctt caccatgctc gagtgcctgt ccctgcctcg ggctgggcgc 420
tcctgcaagg agaccttcac cgtcttctac tatgagagcg atgcggacac ggccacggcc 480
ctcacgccag cctggatgga gaacccctac atcaaggtgg acacggtggc cgcggagcat 540
ctcacccgga agcgccctgg ggccgaggcc accgggaagg tgaatgtcaa gacgctgcgt 600
ctgggaccgc tcagcaaggc tggcttctac ctggccttcc aggaccaggg tgcctgcatg 660
gccctgctat ccctgcacct cttctacaaa aagtgcgccc agctgactgt gaacctgact 720
cgattcccgg agactgtgcc tcgggagctg gttgtgcccg tggccggtag ctgcgtggtg 780
gatgccgtcc ccgcccctgg ccccagcccc agcctctact gccgtgagga tggccagtgg 840
gccgaacagc cggtcacggg ctgcagctgt gctccggggt tcgaggcagc tgaggggaac 900
accaagtgcc gagggcgccg agggtcccag cagcgtgcgg ttcctgaaga cgtcagaaaa 960
ccgggcagag ctgcgggggc tgaagcgggg agccagctac ctggtgcagg tacgggcgcg 1020
ctctgaggcc ggctacgggc ccttcggcca ggaacatcac agccagaccc aactggatga 1080
gagcgagggc tggcgggagc agctggccct gattgcgggc acggcagtcg tgggtgtggt 1140
cctggtcctg gtggtcattg tggtcgcagt tctctgcctc aggaagcaga gcaatgggag 1200
agaagcagaa tattcggaca aacacggaca gtatctcatc ggacatggta ctaaggtcta 1260
catcgacccc ttcacttatg aagaccctaa tgaggctgtg agggaatttg caaaagagat 1320
cgatgtctcc tacgtcaaga ttgaagaggt gat                              1353

<210> 157
<211> 306
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR012C08

<400> 157
Met Glu Leu Arg Val Leu Leu Cys Trp Ala Ser Leu Ala Ala Ala Leu
 1               5                  10                  15      
Glu Glu Thr Leu Leu Asn Thr Lys Leu Glu Thr Ala Asp Leu Lys Trp
            20                  25                  30          
Val Thr Phe Pro Gln Val Asp Gly Gln Trp Glu Glu Leu Ser Gly Leu
        35                  40                  45              
Asp Glu Glu Gln His Ser Val Arg Thr Tyr Glu Val Cys Asp Val Gln
    50                  55                  60                  
Arg Ala Pro Gly Gln Ala His Trp Leu Arg Thr Gly Trp Val Pro Arg
65                  70                  75                  80  
Arg Gly Ala Val His Val Tyr Ala Thr Leu Arg Phe Thr Met Leu Glu
                85                  90                  95      
Cys Leu Ser Leu Pro Arg Ala Gly Arg Ser Cys Lys Glu Thr Phe Thr
            100                 105                 110         
Val Phe Tyr Tyr Glu Ser Asp Ala Asp Thr Ala Thr Ala Leu Thr Pro
        115                 120                 125             
Ala Trp Met Glu Asn Pro Tyr Ile Lys Val Asp Thr Val Ala Ala Glu
    130                 135                 140                 
His Leu Thr Arg Lys Arg Pro Gly Ala Glu Ala Thr Gly Lys Val Asn
145                 150                 155                 160 
Val Lys Thr Leu Arg Leu Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu
                165                 170                 175     
Ala Phe Gln Asp Gln Gly Ala Cys Met Ala Leu Leu Ser Leu His Leu
            180                 185                 190         
Phe Tyr Lys Lys Cys Ala Gln Leu Thr Val Asn Leu Thr Arg Phe Pro
        195                 200                 205             
Glu Thr Val Pro Arg Glu Leu Val Val Pro Val Ala Gly Ser Cys Val
    210                 215                 220                 
Val Asp Ala Val Pro Ala Pro Gly Pro Ser Pro Ser Leu Tyr Cys Arg
225                 230                 235                 240 
Glu Asp Gly Gln Trp Ala Glu Gln Pro Val Thr Gly Cys Ser Cys Ala
                245                 250                 255     
Pro Gly Phe Glu Ala Ala Glu Gly Asn Thr Lys Cys Arg Gly Arg Arg
            260                 265                 270         
Gly Ser Gln Gln Arg Ala Val Pro Glu Asp Val Arg Lys Pro Gly Arg
        275                 280                 285             
Ala Ala Gly Ala Glu Ala Gly Ser Gln Leu Pro Gly Ala Gly Thr Gly
    290                 295                 300                 
Ala Leu
305     

<210> 158
<211> 1813
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR012D11

<400> 158
actcagttcg gatcctaccc gagtgaggcg gcgccatgga gctccgggtg ctgctctgct 60
gggcttcgtt ggccgcagct ttggaagaga ccctgctgaa cacaaaattg gaaactgctg 120
atctgaagtg ggtgacattc cctcaggtgg acgggcagtg ggaggaactg agcggcctgg 180
atgaggaaca gcacagcgtg cgcacctacg aagtgtgtga cgtgcagcgt gccccgggcc 240
aggcccactg gcttcgcaca ggttgggtcc cacggcgggg cgccgtccac gtgtacgcca 300
cgctgcgctt caccatgctc gagtgcctgt ccctgcctcg ggctgggcgc tcctgcaagg 360
agaccttcac cgtcttctac tatgagagcg atgcggacac ggccacggcc ctcacgccag 420
cctggatgga gaacccctac atcaaggtgg acacggtggc cgcggagcat ctcacccgga 480
agcgccctgg ggccgaggcc accgggaagg tgaatgtcaa gacgctgcgt ctgggaccgc 540
tcagcaaggc tggcttctac ctggccttcc aggaccaggg tgcctgcatg gccctgctat 600
ccctgcacct cttctacaaa aagtgcgccc agctgactgt gaacctgact cgattcccgg 660
agactgtgcc tcgggagctg gttgtgcccg tggccggtag ctgcgtggtg gatgccgtcc 720
ccgcccctgg ccccagcccc agcctctact gccgtgagga tggccagtgg gccgaacagc 780
cggtcacggg ctgcagctgt gctccggggt tcgaggcagc tgaggggaac accaagtgcc 840
gagcctgtgc ccagggcacc ttcaagcccc tgtcaggaga agggtcctgc cagccatgcc 900
cagccaatag ccactctaac accattggat cagccgtctg ccagtgccgc gtcgggtact 960
tccgggcacg cacagacccc cggggtgcac cctgcaccac ccctccttcg gctccgcgga 1020
gcgtggtttc ccgcctgaac ggctcctccc tgcacctgga atggagtgcc cccctggagt 1080
ctggtggccg agaggacctc acctacgccc tccgctgccg ggagtgccga cccggaggct 1140
cctgtgcgcc ctgcggggga gacctgactt ttgaccccgg cccccgggac ctggtggagc 1200
cctgggtggt ggttcgaggg ctacgtcctg acttcaccta tacctttgag gtcactgcat 1260
tgaacggggt atcctcctta gccacggggc ccgtcccatt tgagcctgtc aatgtcacca 1320
ctgaccgaga ggtacctcct gcagtgtctg acatccgggt gacgcggtcc tcacccagca 1380
gcttgagcct ggcctgggct gttccccggg cacccagtgg ggctgtgctg gactacgagg 1440
tcaaatacca tgagaagggc gccgagggtc ccagcagcgt gcggttcctg aagacgtcag 1500
aaaaccgggc agagctgcgg gggctgaagc ggggagccag ctacctggtg cagagagcga 1560
gggctggcgg gagcagctgg ccctgattgc gggcacggca gtcgtgggtg tggtcctggt 1620
cctggtggtc attgtggtcg cagttctctg cctcaggaag cagagcaatg ggagagaagc 1680
agaatattcg gacaaacacg gacagtatct catcggacat ggtactaagg tctacatcga 1740
ccccttcact tatgaagacc ctaatgaggc tgtgagggaa tttgcaaaag agatcgatgt 1800
ctcctacgtc aag                                                    1813

<210> 159
<211> 516
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR012D11

<400> 159
Met Glu Leu Arg Val Leu Leu Cys Trp Ala Ser Leu Ala Ala Ala Leu
 1               5                  10                  15      
Glu Glu Thr Leu Leu Asn Thr Lys Leu Glu Thr Ala Asp Leu Lys Trp
            20                  25                  30          
Val Thr Phe Pro Gln Val Asp Gly Gln Trp Glu Glu Leu Ser Gly Leu
        35                  40                  45              
Asp Glu Glu Gln His Ser Val Arg Thr Tyr Glu Val Cys Asp Val Gln
    50                  55                  60                  
Arg Ala Pro Gly Gln Ala His Trp Leu Arg Thr Gly Trp Val Pro Arg
65                  70                  75                  80  
Arg Gly Ala Val His Val Tyr Ala Thr Leu Arg Phe Thr Met Leu Glu
                85                  90                  95      
Cys Leu Ser Leu Pro Arg Ala Gly Arg Ser Cys Lys Glu Thr Phe Thr
            100                 105                 110         
Val Phe Tyr Tyr Glu Ser Asp Ala Asp Thr Ala Thr Ala Leu Thr Pro
        115                 120                 125             
Ala Trp Met Glu Asn Pro Tyr Ile Lys Val Asp Thr Val Ala Ala Glu
    130                 135                 140                 
His Leu Thr Arg Lys Arg Pro Gly Ala Glu Ala Thr Gly Lys Val Asn
145                 150                 155                 160 
Val Lys Thr Leu Arg Leu Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu
                165                 170                 175     
Ala Phe Gln Asp Gln Gly Ala Cys Met Ala Leu Leu Ser Leu His Leu
            180                 185                 190         
Phe Tyr Lys Lys Cys Ala Gln Leu Thr Val Asn Leu Thr Arg Phe Pro
        195                 200                 205             
Glu Thr Val Pro Arg Glu Leu Val Val Pro Val Ala Gly Ser Cys Val
    210                 215                 220                 
Val Asp Ala Val Pro Ala Pro Gly Pro Ser Pro Ser Leu Tyr Cys Arg
225                 230                 235                 240 
Glu Asp Gly Gln Trp Ala Glu Gln Pro Val Thr Gly Cys Ser Cys Ala
                245                 250                 255     
Pro Gly Phe Glu Ala Ala Glu Gly Asn Thr Lys Cys Arg Ala Cys Ala
            260                 265                 270         
Gln Gly Thr Phe Lys Pro Leu Ser Gly Glu Gly Ser Cys Gln Pro Cys
        275                 280                 285             
Pro Ala Asn Ser His Ser Asn Thr Ile Gly Ser Ala Val Cys Gln Cys
    290                 295                 300                 
Arg Val Gly Tyr Phe Arg Ala Arg Thr Asp Pro Arg Gly Ala Pro Cys
305                 310                 315                 320 
Thr Thr Pro Pro Ser Ala Pro Arg Ser Val Val Ser Arg Leu Asn Gly
                325                 330                 335     
Ser Ser Leu His Leu Glu Trp Ser Ala Pro Leu Glu Ser Gly Gly Arg
            340                 345                 350         
Glu Asp Leu Thr Tyr Ala Leu Arg Cys Arg Glu Cys Arg Pro Gly Gly
        355                 360                 365             
Ser Cys Ala Pro Cys Gly Gly Asp Leu Thr Phe Asp Pro Gly Pro Arg
    370                 375                 380                 
Asp Leu Val Glu Pro Trp Val Val Val Arg Gly Leu Arg Pro Asp Phe
385                 390                 395                 400 
Thr Tyr Thr Phe Glu Val Thr Ala Leu Asn Gly Val Ser Ser Leu Ala
                405                 410                 415     
Thr Gly Pro Val Pro Phe Glu Pro Val Asn Val Thr Thr Asp Arg Glu
            420                 425                 430         
Val Pro Pro Ala Val Ser Asp Ile Arg Val Thr Arg Ser Ser Pro Ser
        435                 440                 445             
Ser Leu Ser Leu Ala Trp Ala Val Pro Arg Ala Pro Ser Gly Ala Val
    450                 455                 460                 
Leu Asp Tyr Glu Val Lys Tyr His Glu Lys Gly Ala Glu Gly Pro Ser
465                 470                 475                 480 
Ser Val Arg Phe Leu Lys Thr Ser Glu Asn Arg Ala Glu Leu Arg Gly
                485                 490                 495     
Leu Lys Arg Gly Ala Ser Tyr Leu Val Gln Arg Ala Arg Ala Gly Gly
            500                 505                 510         
Ser Ser Trp Pro
        515     

<210> 160
<211> 1801
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR012E11

<400> 160
actcagttcg gatcctaccc gagtgaggcg gcgccatgga gctccgggtg ctgctctgct 60
gggcttcgtt ggccgcagct ttggaagaga ccctgctgaa cacaaaattg gaaactgctg 120
atctgaagtg ggtgacattc cctcaggtgg acgggcagtg ggaggaactg agcggcctgg 180
atgaggaaca gcacagcgtg cgcacctacg aagtgtgtga cgtgcagcgt gccccgggcc 240
aggcccactg gcttcgcaca ggttgggtcc cacggcgggg cgccgtccac gtgtacgcca 300
cgctgcgctt caccatgctc gagtgcctgt ccctgcctcg ggctgggcgc tcctgcaagg 360
agaccttcac cgtcttctac tatgagagcg atgcggacac ggccacggcc ctcacgccag 420
cctggatgga gaacccctac atcaaggtgg acacggtggc cgcggagcat ctcacccgga 480
agcgccctgg ggccgaggcc accgggaagg tgaatgtcaa gacgctgcgt ctgggaccgc 540
tcagcaaggc tggcttctac ctggccttcc aggaccaggg tgcctgcatg gccctgctat 600
ccctgcacct cttctacaaa aagtgcgccc agctgactgt gaacctgact cgattcccgg 660
agactgtgcc tcgggagctg gttgtgcccg tggccggtag ctgcgtggtg gatgccgtcc 720
ccgcccctgg ccccagcccc agcctctact gccgtgagga tggccagtgg gccgaacagc 780
cggtcacggg ctgcagctgt gctccggggt tcgaggcagc tgaggggaac accaagtgcc 840
gagcctgtgc ccagggcacc ttcaagcccc tgtcaggaga agggtcctgc cagccatgcc 900
cagccaatag ccactctaac accattggat cagccgtctg ccagtgccgc gtcgggtact 960
tccgggcacg cacagacccc cggggtgcac cctgcaccac ccctccttcg gctccgcgga 1020
gcgtggtttc ccgcctgaac ggctcctccc tgcacctgga atggagtgcc cccctggagt 1080
ctggtggccg agaggacctc acctacgccc tccgctgccg ggagtgccga cccggaggct 1140
cctgtgcgcc ctgcggggga gacctgactt ttgaccccgg cccccgggac ctggtggagc 1200
cctgggtggt ggttcgaggg ctacgtcctg acttcaccta tacctttgag tacctcctgc 1260
agtgtctgac atccgggtga cgcggtcctc acccagcagc ttgagcctgg cctgggctgt 1320
tccccgggca cccagtgggg ctgtgctgga ctacgaggtc aaataccatg agaagggcgc 1380
cgagggtccc agcagcgtgc ggttcctgaa gacgtcagaa aaccgggcag agctgcgggg 1440
gctgaagcgg ggagccagct acctggtgca ggtacgggcg cgctctgagg ccggctacgg 1500
gcccttcggc caggaacatc acagccagac ccaactggat gagagcgagg gctggcggga 1560
gcagctggcc ctgattgcgg gcacggcagt cgtgggtgtg gtcctggtcc tggtggtcat 1620
tgtggtcgca gttctctgcc tcaggaagca gagcaatggg agagaagcag aatattcgga 1680
caaacacgga cagtatctca tcggacatgg tactaaggtc tacatcgacc ccttcactta 1740
tgaagaccct aatgaggctg tgagggaatt tgcaaaagag atcgatgtct cctacgtcaa 1800
g                                                                 1801

<210> 161
<211> 414
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR012E11

<400> 161
Met Glu Leu Arg Val Leu Leu Cys Trp Ala Ser Leu Ala Ala Ala Leu
 1               5                  10                  15      
Glu Glu Thr Leu Leu Asn Thr Lys Leu Glu Thr Ala Asp Leu Lys Trp
            20                  25                  30          
Val Thr Phe Pro Gln Val Asp Gly Gln Trp Glu Glu Leu Ser Gly Leu
        35                  40                  45              
Asp Glu Glu Gln His Ser Val Arg Thr Tyr Glu Val Cys Asp Val Gln
    50                  55                  60                  
Arg Ala Pro Gly Gln Ala His Trp Leu Arg Thr Gly Trp Val Pro Arg
65                  70                  75                  80  
Arg Gly Ala Val His Val Tyr Ala Thr Leu Arg Phe Thr Met Leu Glu
                85                  90                  95      
Cys Leu Ser Leu Pro Arg Ala Gly Arg Ser Cys Lys Glu Thr Phe Thr
            100                 105                 110         
Val Phe Tyr Tyr Glu Ser Asp Ala Asp Thr Ala Thr Ala Leu Thr Pro
        115                 120                 125             
Ala Trp Met Glu Asn Pro Tyr Ile Lys Val Asp Thr Val Ala Ala Glu
    130                 135                 140                 
His Leu Thr Arg Lys Arg Pro Gly Ala Glu Ala Thr Gly Lys Val Asn
145                 150                 155                 160 
Val Lys Thr Leu Arg Leu Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu
                165                 170                 175     
Ala Phe Gln Asp Gln Gly Ala Cys Met Ala Leu Leu Ser Leu His Leu
            180                 185                 190         
Phe Tyr Lys Lys Cys Ala Gln Leu Thr Val Asn Leu Thr Arg Phe Pro
        195                 200                 205             
Glu Thr Val Pro Arg Glu Leu Val Val Pro Val Ala Gly Ser Cys Val
    210                 215                 220                 
Val Asp Ala Val Pro Ala Pro Gly Pro Ser Pro Ser Leu Tyr Cys Arg
225                 230                 235                 240 
Glu Asp Gly Gln Trp Ala Glu Gln Pro Val Thr Gly Cys Ser Cys Ala
                245                 250                 255     
Pro Gly Phe Glu Ala Ala Glu Gly Asn Thr Lys Cys Arg Ala Cys Ala
            260                 265                 270         
Gln Gly Thr Phe Lys Pro Leu Ser Gly Glu Gly Ser Cys Gln Pro Cys
        275                 280                 285             
Pro Ala Asn Ser His Ser Asn Thr Ile Gly Ser Ala Val Cys Gln Cys
    290                 295                 300                 
Arg Val Gly Tyr Phe Arg Ala Arg Thr Asp Pro Arg Gly Ala Pro Cys
305                 310                 315                 320 
Thr Thr Pro Pro Ser Ala Pro Arg Ser Val Val Ser Arg Leu Asn Gly
                325                 330                 335     
Ser Ser Leu His Leu Glu Trp Ser Ala Pro Leu Glu Ser Gly Gly Arg
            340                 345                 350         
Glu Asp Leu Thr Tyr Ala Leu Arg Cys Arg Glu Cys Arg Pro Gly Gly
        355                 360                 365             
Ser Cys Ala Pro Cys Gly Gly Asp Leu Thr Phe Asp Pro Gly Pro Arg
    370                 375                 380                 
Asp Leu Val Glu Pro Trp Val Val Val Arg Gly Leu Arg Pro Asp Phe
385                 390                 395                 400 
Thr Tyr Thr Phe Glu Tyr Leu Leu Gln Cys Leu Thr Ser Gly
                405                 410                 

<210> 162
<211> 405
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGFR.a

<400> 162
Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala
 1               5                  10                  15      
Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln
            20                  25                  30          
Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe
        35                  40                  45              
Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn
    50                  55                  60                  
Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys
65                  70                  75                  80  
Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val
                85                  90                  95      
Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr
            100                 105                 110         
Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn
        115                 120                 125             
Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu
    130                 135                 140                 
His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu
145                 150                 155                 160 
Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met
                165                 170                 175     
Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro
            180                 185                 190         
Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln
        195                 200                 205             
Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg
    210                 215                 220                 
Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys
225                 230                 235                 240 
Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp
                245                 250                 255     
Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro
            260                 265                 270         
Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly
        275                 280                 285             
Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His
    290                 295                 300                 
Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu
305                 310                 315                 320 
Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val
                325                 330                 335     
Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn
            340                 345                 350         
Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp
        355                 360                 365             
Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr
    370                 375                 380                 
Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu
385                 390                 395                 400 
Ile Thr Gly Leu Ser
                405 

<210> 163
<211> 680
<212> PRT
<213> Homo sapiens

<220> 
<223> ERBB2.1.d

<400> 163
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Leu Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp
            20                  25                  30          
Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu
        35                  40                  45              
Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu
    50                  55                  60                  
Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln
65                  70                  75                  80  
Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val
                85                  90                  95      
Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp
            100                 105                 110         
Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr
        115                 120                 125             
Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu
    130                 135                 140                 
Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn
145                 150                 155                 160 
Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His
                165                 170                 175     
Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg
            180                 185                 190         
Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly
        195                 200                 205             
Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly
    210                 215                 220                 
Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu
225                 230                 235                 240 
Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala
                245                 250                 255     
Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala
            260                 265                 270         
Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu
        275                 280                 285             
Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn
    290                 295                 300                 
Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His
305                 310                 315                 320 
Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys
                325                 330                 335     
Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu
            340                 345                 350         
Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly
        355                 360                 365             
Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp
    370                 375                 380                 
Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln
385                 390                 395                 400 
Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala
                405                 410                 415     
Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val
            420                 425                 430         
Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln
        435                 440                 445             
Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly
    450                 455                 460                 
Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His
465                 470                 475                 480 
Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu
                485                 490                 495     
His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala
            500                 505                 510         
Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr
        515                 520                 525             
Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu
    530                 535                 540                 
Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg
545                 550                 555                 560 
His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val
                565                 570                 575     
Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr
            580                 585                 590         
Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro
        595                 600                 605             
Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala
    610                 615                 620                 
Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp
625                 630                 635                 640 
Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Arg Leu Ala Trp Thr Pro
                645                 650                 655     
Gly Cys Thr Leu His Cys Pro Ser Leu Pro His Trp Met Leu Gly Gly
            660                 665                 670         
His Cys Cys Arg Glu Gly Thr Pro
        675                 680 

<210> 164
<211> 633
<212> PRT
<213> Homo sapiens

<220> 
<223> ERBB2.1.e

<400> 164
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu
            340                 345                 350         
Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys
        355                 360                 365             
Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp
    370                 375                 380                 
Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe
385                 390                 395                 400 
Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro
                405                 410                 415     
Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg
            420                 425                 430         
Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu
        435                 440                 445             
Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly
    450                 455                 460                 
Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val
465                 470                 475                 480 
Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr
                485                 490                 495     
Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His
            500                 505                 510         
Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys
        515                 520                 525             
Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys
    530                 535                 540                 
Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys
545                 550                 555                 560 
Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys
                565                 570                 575     
Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp
            580                 585                 590         
Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu
        595                 600                 605             
Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln
    610                 615                 620                 
Pro Cys Pro Ile Asn Cys Thr His Ser
625                 630             

<210> 165
<211> 575
<212> PRT
<213> Homo sapiens

<220> 
<223> ERBB2.1.f

<400> 165
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu
            340                 345                 350         
Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys
        355                 360                 365             
Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp
    370                 375                 380                 
Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe
385                 390                 395                 400 
Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro
                405                 410                 415     
Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg
            420                 425                 430         
Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu
        435                 440                 445             
Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly
    450                 455                 460                 
Leu Ala Leu Ile His His Tyr Thr His Leu Cys Phe Val His Thr Val
465                 470                 475                 480 
Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr
                485                 490                 495     
Ala Asn Arg Pro Glu Asp Glu Cys Gly Lys Thr Gly Ser Pro Val Cys
            500                 505                 510         
Ala Leu Pro Ile Cys Gln His Thr Ala Val Pro Arg Gly Pro Trp Gln
        515                 520                 525             
Gln Arg Ser Trp Thr Cys Ala Asp Cys Pro Ser Leu Cys Thr Leu Leu
    530                 535                 540                 
Asp Ser Ala Gln Leu Trp Leu Ala Trp Pro Leu Gly Met Ala Ser Leu
545                 550                 555                 560 
Ala Gly Ser Tyr Leu Pro Trp His Pro Ser Leu Pro Leu Cys Phe
                565                 570                 575 

<210> 166
<211> 90
<212> PRT
<213> Homo sapiens

<220> 
<223> ERBB2.a

<400> 166
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Val Arg Pro Val Gly
65                  70                  75                  80  
Asn Pro Ala Arg Pro Cys Leu Gln Leu Gly
                85                  90  

<210> 167
<211> 419
<212> PRT
<213> Artificial Sequence

<220> 
<223> ERBB2.c BUILD 31

<400> 167
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val
            340                 345                 350         
Pro Val Pro Leu Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser
        355                 360                 365             
Phe Leu Arg Pro Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro
    370                 375                 380                 
Leu Ala Pro Leu Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val
385                 390                 395                 400 
Gly Arg Gly Pro Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg
                405                 410                 415     
Tyr Glu Gly

<210> 168
<211> 331
<212> PRT
<213> Artificial Sequence

<220> 
<223> ERBB3.d BUILD 31

<400> 168
Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu
 1               5                  10                  15      
Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr
            20                  25                  30          
Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr
        35                  40                  45              
Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60                  
Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile
65                  70                  75                  80  
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr
                85                  90                  95      
Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp
            100                 105                 110         
Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser
        115                 120                 125             
His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser
    130                 135                 140                 
Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr
145                 150                 155                 160 
Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val
                165                 170                 175     
Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly
            180                 185                 190         
Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr
        195                 200                 205             
Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn
    210                 215                 220                 
Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp
225                 230                 235                 240 
Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val
                245                 250                 255     
Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu
            260                 265                 270         
Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala
        275                 280                 285             
Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala
    290                 295                 300                 
Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys
305                 310                 315                 320 
Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Phe
                325                 330    

<210> 169
<211> 878
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (9)...(695)
<223> SR001E12

<400> 169
gaactggg atg tgg agc tgg aag tgc ctc ctc ttc tgg gct gtg ctg gtc  50
         Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val
          1               5                   10
 
aca gcc aca ctc tgc acc gct agg ccg tcc ccg acc ttg cct gaa caa   98
Thr Ala Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln
 15                  20                  25                  30
 
gat gct ctc ccc tcc tcg gag gat gat gat gat gat gat gac tcc tct   146
Asp Ala Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser
                 35                  40                  45
 
tca gag gag aaa gaa aca gat aac acc aaa cca aac ccc gta gct cca   194
Ser Glu Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Pro Val Ala Pro
             50                  55                  60
 
tat tgg aca tcc cca gaa aag atg gaa aag aaa ttg cat gca gtg ccg   242
Tyr Trp Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala Val Pro
         65                  70                  75
 
gct gcc aag aca gtg aag ttc aaa tgc cct tcc agt ggg acc cca aac   290
Ala Ala Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr Pro Asn
     80                  85                  90
 
ccc aca ctg cgc tgg ttg aaa aat ggc aaa gaa ttc aaa cct gac cac   338
Pro Thr Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Pro Asp His
 95                 100                 105                 110
 
aga att gga ggc tac aag gtc cgt tat gcc acc tgg agc atc ata atg   386
Arg Ile Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile Ile Met
                115                 120                 125
 
gac tct gtg gtg ccc tct gac aag ggc aac tac acc tgc att gtg gag   434
Asp Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile Val Glu
            130                 135                 140
 
aat gag tac ggc agc atc aac cac aca tac cag ctg gat gtc gtg gag   482
Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu Asp Val Val Glu
        145                 150                 155
 
cgg tcc cct cac cgg ccc atc ctg caa gca ggg ttg ccc gcc aac aaa   530
Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Lys
    160                 165                 170
 
aca gtg gcc ctg ggt agc aac gtg gag ttc atg tgt aag gtg tac agt   578
Thr Val Ala Leu Gly Ser Asn Val Glu Phe Met Cys Lys Val Tyr Ser
175                 180                 185                 190
 
gac ccg cag ccg cac atc cag tgg cta aag cac atc gag gtg aat ggg   626
Asp Pro Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val Asn Gly
                195                 200                 205
 
agc aag att ggc cca gac aac ctg cct tat gtc cag atc ttg aag ccc   674
Ser Lys Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu Lys Pro
            210                 215                 220
 
tgg aag aga ggc cgg cag tga tgacctcgcc cctgtacctg gagatcatca      725
Trp Lys Arg Gly Arg Gln  *
        225
 
tctattgcac aggggccttc ctcatctcct gcatggtggg gtcggtcatc gtctacaaga 785
tgaagagtgg taccaagaag agtgacttcc acagccagat ggctgtgcac aagctggcca 845
agagcatccc tctgcgcaga caggtaacag aaa                              878

<210> 170
<211> 228
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR001E12

<400> 170
Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala
 1               5                  10                  15      
Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala
            20                  25                  30          
Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu
        35                  40                  45              
Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp
    50                  55                  60                  
Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala Val Pro Ala Ala
65                  70                  75                  80  
Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr
                85                  90                  95      
Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile
            100                 105                 110         
Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser
        115                 120                 125             
Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu
    130                 135                 140                 
Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser
145                 150                 155                 160 
Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val
                165                 170                 175     
Ala Leu Gly Ser Asn Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro
            180                 185                 190         
Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys
        195                 200                 205             
Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu Lys Pro Trp Lys
    210                 215                 220                 
Arg Gly Arg Gln
225             

<210> 171
<211> 965
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR022C02

<400> 171
atgtggagct ggaagtgcct cctcttctgg gctgtgctgg tcacagccac actctgcacc 60
gctaggccgt ccccgacctt gcctgaacaa gatgctctcc cctcctcgga ggatgatgat 120
gatgatgatg actcctcttc agaggagaaa gaaacagata acaccaaacc aaaccgtatg 180
cccgtagctc catattggac atccccagaa aagatggaaa agaaattgca tgcagtgccg 240
gctgccaaga cagtgaagtt caaatgccct tccagtggga ccccaaaccc cacactgcgc 300
tggttggaaa atggcaaaga attcaaacct ggccacagaa ttggaggcta caaggtccgt 360
tatgccacct ggagcatcat aatggactct gtggtgccct ctgacaaggg caactacacc 420
tgcattgtgg agaatgagta cggcagcatc aaccacacat accagctgga tgtcgtggag 480
cggtcccctc accggcccat cctgcaagca gggttgcccg ccaacaaaac agtggccctg 540
ggtagcaacg tggagttcat gtgtaaggtg tacagtgacc cgcagccgca catccagtgg 600
ctaaagcaca tcgaggtgaa tgggagcaag attggcccgg acaacctgcc ttatgtccag 660
atcttgaaga ctgctggagt taataccacc gacaaagaga tggaggtgct tcacttaaga 720
aatgtctcct ttgaggacgc aggggagtat acgtgcttgg cgggtaactc tatcggactc 780
tcccatcact ctgcatggtt gaccgttctg gaaggtacac actgtaactt ctcctctcga 840
tgtcctgccc tcgccacggg cacgggggga gcatgcattt ccaggcttgg ggagacacag 900
aggcaggaga gctggaagaa tgggctcctg cctgcctggt gccacatcct gccccagctt 960
tgagg                                                             965

<210> 172
<211> 320
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR022C02

<400> 172
Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala
 1               5                  10                  15      
Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala
            20                  25                  30          
Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu
        35                  40                  45              
Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Arg Met Pro Val Ala Pro
    50                  55                  60                  
Tyr Trp Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala Val Pro
65                  70                  75                  80  
Ala Ala Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr Pro Asn
                85                  90                  95      
Pro Thr Leu Arg Trp Leu Glu Asn Gly Lys Glu Phe Lys Pro Gly His
            100                 105                 110         
Arg Ile Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile Ile Met
        115                 120                 125             
Asp Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile Val Glu
    130                 135                 140                 
Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu Asp Val Val Glu
145                 150                 155                 160 
Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Lys
                165                 170                 175     
Thr Val Ala Leu Gly Ser Asn Val Glu Phe Met Cys Lys Val Tyr Ser
            180                 185                 190         
Asp Pro Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val Asn Gly
        195                 200                 205             
Ser Lys Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu Lys Thr
    210                 215                 220                 
Ala Gly Val Asn Thr Thr Asp Lys Glu Met Glu Val Leu His Leu Arg
225                 230                 235                 240 
Asn Val Ser Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn
                245                 250                 255     
Ser Ile Gly Leu Ser His His Ser Ala Trp Leu Thr Val Leu Glu Gly
            260                 265                 270         
Thr His Cys Asn Phe Ser Ser Arg Cys Pro Ala Leu Ala Thr Gly Thr
        275                 280                 285             
Gly Gly Ala Cys Ile Ser Arg Leu Gly Glu Thr Gln Arg Gln Glu Ser
    290                 295                 300                 
Trp Lys Asn Gly Leu Leu Pro Ala Trp Cys His Ile Leu Pro Gln Leu
305                 310                 315                 320 

<210> 173
<211> 801
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR022C10

<400> 173
atggtcagct ggggtcgttt catctgcctg gtcgtggtca ccatggcaac cttgtccctg 60
gcccggccct ccttcagttt agttgaggat accacattag agccagaaga gccaccaacc 120
aaataccaaa tctctcaacc agaagtgtac gtggctgcgc caggggagtc gctagaggtg 180
cgctgcctgt tgaaagatgc cgccgtgatc agttggacta aggatggggt gcacttgggg 240
cccaacaata ggacagtgct tattggggag tacttgcaga taaagggcgc cacgcctaga 300
gactccggcc tctatgcttg tactgccagt aggactgtag acagtgaaac ttggtacttc 360
atggtgaatg tcacagatgc catctcatcc ggagatgatg aggatgacac cgatggtgcg 420
gaagattttg tcagtgagaa cagtaacaac aagagagcac catactggac caacacagaa 480
aagatggaaa agcggctcca tgctgtgcct gcggccaaca ctgtcaagtt tcgctgccca 540
gccgggggga acccaatgcc aaccatgcgg tggctgaaaa acgggaagga gtttaagcag 600
gagcatcgca ttggaggcta caaggtacga aaccagcact ggagcctcat tatggaaagt 660
gtggtcccat ctgacaaggg aaattatacc tgtgtggtgg agaatgaata cgggtccatc 720
aatcacacgt accacctgga tgttgtgggt gagtctgcct ctcctcgtgt ggcggctgca 780
taccagccca ttcttgcttg a                                           801

<210> 174
<211> 266
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR022C10

<400> 174
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu
        35                  40                  45              
Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu
    50                  55                  60                  
Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly
65                  70                  75                  80  
Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly
                85                  90                  95      
Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr
            100                 105                 110         
Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile
        115                 120                 125             
Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val
    130                 135                 140                 
Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu
145                 150                 155                 160 
Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys
                165                 170                 175     
Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu
            180                 185                 190         
Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys
        195                 200                 205             
Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser
    210                 215                 220                 
Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile
225                 230                 235                 240 
Asn His Thr Tyr His Leu Asp Val Val Gly Glu Ser Ala Ser Pro Arg
                245                 250                 255     
Val Ala Ala Ala Tyr Gln Pro Ile Leu Ala
            260                 265     

<210> 175
<211> 953
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR022C11

<400> 175
atggtcagct ggggtcgttt catctgcctg gtcgtggtca ccatggcaac cttgtccctg 60
gcccggccct ccttcagttt agttgaggat accacattag agccagaaga gccaccaacc 120
aaataccaaa tctctcaacc agaagtgtac gtggctgcgc caggggagtc gctagaggtg 180
cgctgcctgt tgaaagatgc cgccgtgatc agttggacta aggatggggt gcacttgggg 240
cccaacaata ggacagtgct tattggggag tacttgcaga taaagggcgc cacgcctaga 300
gactccggcc tctatgcttg tactgccagt aggactgtag acagtgaaac ttggtacttc 360
atggtgaatg tcacagatgc catctcatcc ggagatgatg aggatgacac cgatggtgcg 420
gaagattttg tcagtgagaa cagtaacaac aagagagcac catactggac caacacagaa 480
aagatggaaa agcggctcca tgctgtgcct gcggccaaca ctgtcaagtt tcgctgccca 540
gccgggggga acccaatgcc aaccatgcgg tggctgaaaa acgggaagga gtttaagcag 600
gagcatcgca ttggaggcta caaggtacga aaccagcact ggagcctcat tatggaaagt 660
gtggtcccat ctgacaaggg aaattatacc tgtgtggtgg agaatgaata cgggtccatc 720
aatcacacgt accacctgga tgttgtggag cgatcgcctc accggcccat cctccaagcc 780
ggactgccgg caaatgcctc cacagtggtc ggaggagacg tagagtttgt ctgcaaggtt 840
tacagtgatg cccagcccca catccagtgg atcaagcacg tggaaaagaa cggcagtaaa 900
tacgggcccg acgggctgcc ctacctcaag gttctcaagg tgaggacttt ctg        953

<210> 176
<211> 317
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR022C11

<400> 176
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu
        35                  40                  45              
Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu
    50                  55                  60                  
Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly
65                  70                  75                  80  
Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly
                85                  90                  95      
Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr
            100                 105                 110         
Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile
        115                 120                 125             
Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val
    130                 135                 140                 
Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu
145                 150                 155                 160 
Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys
                165                 170                 175     
Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu
            180                 185                 190         
Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys
        195                 200                 205             
Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser
    210                 215                 220                 
Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile
225                 230                 235                 240 
Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro
                245                 250                 255     
Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly
            260                 265                 270         
Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile
        275                 280                 285             
Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp
    290                 295                 300                 
Gly Leu Pro Tyr Leu Lys Val Leu Lys Val Arg Thr Phe
305                 310                 315         

<210> 177
<211> 844
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR022D04

<400> 177
atggtcagct ggggtcgttt catctgcctg gtcgtggtca ccatggcaac cttgtccctg 60
gcccggccct ccttcagttt agttgaggat atcacattag agccagaagg agcaccatac 120
tggaccaaca cagaaaagat ggaaaagcgg ctccatgctg tgcctgcggc caacactgtc 180
aagtttcgct gcccagccgg ggggaaccca atgccaacca tgcggtggct gaaaaacggg 240
aaggagttta agcaggagca tcgcattgga ggctacaagg tacgaaacca gcactggagc 300
ctcattatgg aaagtgtggt cccatctgac aagggaaatt atacctgtgt ggtggagaat 360
gaatacgggt ccatcaatca cacgtaccac ctggatgttg tggagcgatc gcctcaccgg 420
cccatcctcc aagccggact gccggcaaat gcctccacag tggtcggagg agacgtagag 480
tttgtctgca aggtttacag tgatgcccag ccccacatcc agtggatcaa gcacgtggaa 540
aagaacggca gtaaatacgg gcccgacggg ctgccctacc tcaaggttct caaggccgcc 600
ggtgttaaca ccacggacaa agagattgag gttctctata ttcggaatgt aacttttgag 660
gacgctgggg aatatacgtg cttggcgggt aattctattg ggatatcctt tcactccgca 720
tggttgacag ttctgccagg tatatactgt tctttctctc tgggtttttt tcctttttct 780
tggttgactg ctataaaatt aacacagctt ctgttatcag aaatggcccc ttttatcctt 840
gcat                                                              844

<210> 178
<211> 281
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR022D04

<400> 178
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Ile Thr
            20                  25                  30          
Leu Glu Pro Glu Gly Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu
        35                  40                  45              
Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys
    50                  55                  60                  
Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly
65                  70                  75                  80  
Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn
                85                  90                  95      
Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly
            100                 105                 110         
Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr
        115                 120                 125             
Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln
    130                 135                 140                 
Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu
145                 150                 155                 160 
Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile
                165                 170                 175     
Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro
            180                 185                 190         
Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys Glu
        195                 200                 205             
Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly Glu
    210                 215                 220                 
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser Ala
225                 230                 235                 240 
Trp Leu Thr Val Leu Pro Gly Ile Tyr Cys Ser Phe Ser Leu Gly Phe
                245                 250                 255     
Phe Pro Phe Ser Trp Leu Thr Ala Ile Lys Leu Thr Gln Leu Leu Leu
            260                 265                 270         
Ser Glu Met Ala Pro Phe Ile Leu Ala
        275                 280     

<210> 179
<211> 1191
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR022D06

<400> 179
atggtcagct ggggtcgttt catctgcctg gtcgtggtca ccatggcaac cttgtccctg 60
gcccggccct ccttcagttt agttgaggat accacattag agccagaaga gccaccaacc 120
aaataccaaa tctctcaacc agaagtgtac gtggctgcgc caggggagtc gctagaggtg 180
cgctgcctgt tgaaagatgc cgccgtgatc agttggacta aggatggggt gcacttgggg 240
cccaacaata ggacagtgct tattggggag tacttgcaga taaagggcgc cacgcctaga 300
gactccggcc tctatgcttg tactgccagt aggactgtag acagtgaaac ttggtacttc 360
atggtgaatg tcacagatgc catctcatcc ggagatgatg aggatgacac cgatggtgcg 420
gaagattttg tcagtgagaa cagtaacaac aagagagcac catactggac caacacagaa 480
aagacggaaa agcggctcca tgctgtgcct gcggccaaca ctgtcaagtt tcgctgccca 540
gccgggggga acccaatgcc aaccatgcgg tggctgaaaa acgggaagga gtttaagcag 600
gagcatcgca ttggaggcta caaggtacga aaccagcact ggagcctcat tatggaaagt 660
gtggtcccat ctgacaaggg aaattatacc tgtgtggtgg agaatgaata cgggtccatc 720
aatcacacgt accacctgga tgttgtggag cgatcgcctc accggcccat cctccaagcc 780
ggactgccgg caaatgcctc cacagtggtc ggaggagacg tagagtttgt ctgcaaggtt 840
tacagtgatg cccagcccca catccagtgg atcaagcacg tggaaaagaa cggcagtaaa 900
tacgggcccg acgggctgcc ctacctcaag gttctcaagg ccgccggtgt taacaccacg 960
gacaaagaga ttgaggttct ctatattcgg aatgtaactt ttgaggacgc tggggaatat 1020
acgtgcttgg cgggtaattc tattgggata tcctttcact ctgcatggtt gacagttctg 1080
ccaggtatat actgttcttt ctctctgggt ttttttccct tttcttggtt gactgctata 1140
aaattaacac agcttctgtt atcagaaatg gcccctttta tccttgcata a          1191

<210> 180
<211> 396
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR022D06

<400> 180
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu
        35                  40                  45              
Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu
    50                  55                  60                  
Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly
65                  70                  75                  80  
Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly
                85                  90                  95      
Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr
            100                 105                 110         
Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile
        115                 120                 125             
Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val
    130                 135                 140                 
Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu
145                 150                 155                 160 
Lys Thr Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys
                165                 170                 175     
Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu
            180                 185                 190         
Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys
        195                 200                 205             
Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser
    210                 215                 220                 
Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile
225                 230                 235                 240 
Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro
                245                 250                 255     
Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly
            260                 265                 270         
Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile
        275                 280                 285             
Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp
    290                 295                 300                 
Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr
305                 310                 315                 320 
Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp
                325                 330                 335     
Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe
            340                 345                 350         
His Ser Ala Trp Leu Thr Val Leu Pro Gly Ile Tyr Cys Ser Phe Ser
        355                 360                 365             
Leu Gly Phe Phe Pro Phe Ser Trp Leu Thr Ala Ile Lys Leu Thr Gln
    370                 375                 380                 
Leu Leu Leu Ser Glu Met Ala Pro Phe Ile Leu Ala
385                 390                 395     

<210> 181
<211> 366
<212> PRT
<213> Artificial Sequence

<220> 
<223> FGFR2.b BUILD 31

<400> 181
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu
        35                  40                  45              
Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu
    50                  55                  60                  
Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly
65                  70                  75                  80  
Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly
                85                  90                  95      
Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr
            100                 105                 110         
Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile
        115                 120                 125             
Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val
    130                 135                 140                 
Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu
145                 150                 155                 160 
Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys
                165                 170                 175     
Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu
            180                 185                 190         
Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys
        195                 200                 205             
Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser
    210                 215                 220                 
Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile
225                 230                 235                 240 
Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro
                245                 250                 255     
Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly
            260                 265                 270         
Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile
        275                 280                 285             
Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp
    290                 295                 300                 
Gly Leu Pro Tyr Leu Lys Val Leu Lys His Ser Gly Ile Asn Ser Ser
305                 310                 315                 320 
Asn Ala Glu Val Leu Ala Leu Phe Asn Val Thr Glu Ala Asp Ala Gly
                325                 330                 335     
Glu Tyr Ile Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala Asn Gln Ser
            340                 345                 350         
Ala Trp Leu Thr Val Leu Pro Lys Gln Gln Gly Arg Arg Cys
        355                 360                 365    

<210> 182
<211> 713
<212> DNA
<213> Homo sapiens

<220> 
<223> SR002A11

<400> 182
tgggtccctg agagctgtga gaaggagatg cggctgctgc tggccctgtt gggggtcctg 60
ctgagtgtgc ctgggcctcc agtcttgtcc ctggaggcct ctgaggaagt ggagcttgca 120
agcattcatc tatcactgtg tctgcgagag aggactggcc ttgcagggcg cagggcccta 180
agctgggctg cagagctggt gagccctgcc tggctcccag cctggagcag caagagcagg 240
agctgacagt agcccttggg cagcctgtgc gtctgtgctg tgggcgggct gagcgtggtg 300
gccactggta caaggagggc agtcgcctgg cacctgctgg ccgtgtacgg ggctggaggg 360
gccgcctaga gattgccagc ttcctacctg aggatgctgg ccgctacctc tgcctggcac 420
gaggctccat gatcgtcctg cagaatctca ccttgattac aggtgactcc ttgacctcca 480
gcaacgatga tgaggacccc aagtcccata gggacccctc gaataggcac agttaccccc 540
agcaagcacc ctactggaca cacccccagc gcatggagaa gaaactgcat gcagtacctg 600
cggggaacac cgtcaagttc cgctgtccag ctgcaggcaa ccccacgccc accatccgct 660
ggcttaagga tggacaggcc tttcatgggg agaaccgcat tggaggcatt cgg        713

<210> 183
<211> 72
<212> PRT
<213> Homo sapiens

<220> 
<223> SR002A11

<400> 183
Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly
 1               5                  10                  15      
Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Ala Ser
            20                  25                  30          
Ile His Leu Ser Leu Cys Leu Arg Glu Arg Thr Gly Leu Ala Gly Arg
        35                  40                  45              
Arg Ala Leu Ser Trp Ala Ala Glu Leu Val Ser Pro Ala Trp Leu Pro
    50                  55                  60                  
Ala Trp Ser Ser Lys Ser Arg Ser
65                  70          

<210> 184
<211> 1775
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (26)...(1366)
<223> SR002A10

<400> 184
ggtccctgag agctgtgaga aggag atg cgg ctg ctg ctg gcc ctg ttg ggg   52
                            Met Arg Leu Leu Leu Ala Leu Leu Gly
                             1               5
 
gtc ctg ctg agt gtg cct ggg cct cca gtc ttg tcc ctg gag gcc tct   100
Val Leu Leu Ser Val Pro Gly Pro Pro Val Leu Ser Leu Glu Ala Ser
 10                  15                  20                  25
 
gag gaa gtg gag ctt gag ccc tgc ctg gct ccc agc ctg gag cag caa   148
Glu Glu Val Glu Leu Glu Pro Cys Leu Ala Pro Ser Leu Glu Gln Gln
                 30                  35                  40
 
gag cag gag ctg aca gta gcc ctt ggg cag cct gtg cgt ctg tgc tgt   196
Glu Gln Glu Leu Thr Val Ala Leu Gly Gln Pro Val Arg Leu Cys Cys
             45                  50                  55
 
ggg cgg gct gag cgt ggt ggc cac tgg tac aag gag ggc agt cgc ctg   244
Gly Arg Ala Glu Arg Gly Gly His Trp Tyr Lys Glu Gly Ser Arg Leu
         60                  65                  70
 
gca cct gct ggc cgt gta cgg ggc tgg agg ggc cgc cta gag att gcc   292
Ala Pro Ala Gly Arg Val Arg Gly Trp Arg Gly Arg Leu Glu Ile Ala
     75                  80                  85
 
agc ttc cta cct gag gat gct ggc cgc tac ctc tgc ctg gca cga ggc   340
Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr Leu Cys Leu Ala Arg Gly
 90                  95                 100                 105
 
tcc atg atc gtc ctg cag aat ctc acc ttg att aca ggt gac tcc ttg   388
Ser Met Ile Val Leu Gln Asn Leu Thr Leu Ile Thr Gly Asp Ser Leu
                110                 115                 120
 
acc tcc agc aac gat gat gag gac ccc aag tcc cat agg gac ccc tcg   436
Thr Ser Ser Asn Asp Asp Glu Asp Pro Lys Ser His Arg Asp Pro Ser
            125                 130                 135
 
aat agg cac agt tac ccc cag caa gca ccc tac tgg aca cac ccc cag   484
Asn Arg His Ser Tyr Pro Gln Gln Ala Pro Tyr Trp Thr His Pro Gln
        140                 145                 150
 
cgc atg gag aag aaa ctg cat gca gta cct gcg ggg aac acc gtc aag   532
Arg Met Glu Lys Lys Leu His Ala Val Pro Ala Gly Asn Thr Val Lys
    155                 160                 165
 
ttc cgc tgt cca gct gca ggc aac ccc acg ccc acc atc cgc tgg ctt   580
Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Thr Ile Arg Trp Leu
170                 175                 180                 185
 
aag gat gga cag gcc ttt cat ggg gag aac cgc att gga ggc att cgg   628
Lys Asp Gly Gln Ala Phe His Gly Glu Asn Arg Ile Gly Gly Ile Arg
                190                 195                 200
 
ctg cgc cat cag cac tgg agt ctc gtg atg gag agc gtg gtg ccc tcg   676
Leu Arg His Gln His Trp Ser Leu Val Met Glu Ser Val Val Pro Ser
            205                 210                 215
 
gac cgc ggc aca tac acc tgc ctg gta gag aac gct gtg ggc agc atc   724
Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn Ala Val Gly Ser Ile
        220                 225                 230
 
cgc tat aac tac ctg cta gat gtg ctg gag cgg tcc ccg cac cgg ccc   772
Arg Tyr Asn Tyr Leu Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro
    235                 240                 245
 
atc ctg cag gcc ggg ctc ccg gcc aac acc aca gcc gtg gtg ggc agc   820
Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr Ala Val Val Gly Ser
250                 255                 260                 265
 
gac gtg gag ctg ctg tgc aag gtg tac agc gat gcc cag ccc cac atc   868
Asp Val Glu Leu Leu Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile
                270                 275                 280
 
cag tgg ctg aag cac atc gtc atc aac ggc agc agc ttc gga gcc gac   916
Gln Trp Leu Lys His Ile Val Ile Asn Gly Ser Ser Phe Gly Ala Asp
            285                 290                 295
 
ggt ttc ccc tat gtg caa gtc cta aag act gca gac atc aat agc tca   964
Gly Phe Pro Tyr Val Gln Val Leu Lys Thr Ala Asp Ile Asn Ser Ser
        300                 305                 310
 
gag gtg gag gtc ctg tac ctg cgg aac gtg tca gcc gag gac gca ggc   1012
Glu Val Glu Val Leu Tyr Leu Arg Asn Val Ser Ala Glu Asp Ala Gly
    315                 320                 325
 
gag tac acc tgc ctc gca ggc aat tcc atc ggc ctc tcc tac cag tct   1060
Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser Tyr Gln Ser
330                 335                 340                 345
 
gcc tgg ctc acg gtg ctg cca ggt gag cac ctg aag ggc cag gag atg   1108
Ala Trp Leu Thr Val Leu Pro Gly Glu His Leu Lys Gly Gln Glu Met
                350                 355                 360
 
ctg cga gat gcc cct ctg ggc cag cag tgg ggg ctg tgg cct gtt ggg   1156
Leu Arg Asp Ala Pro Leu Gly Gln Gln Trp Gly Leu Trp Pro Val Gly
            365                 370                 375
 
tgg tca gtc tct gtt ggc ctg tgg ggt ctg gcc tgg ggg gca gtg tgt   1204
Trp Ser Val Ser Val Gly Leu Trp Gly Leu Ala Trp Gly Ala Val Cys
        380                 385                 390
 
gga ttt gtg ggt ttg agc tgt atg aca gcc cct ctg tgc ctc tcc aca   1252
Gly Phe Val Gly Leu Ser Cys Met Thr Ala Pro Leu Cys Leu Ser Thr
    395                 400                 405
 
cgt ggc cgt cca tgt gac cgt ctg ctg agg tgt ggg tgc ctg gga ctg   1300
Arg Gly Arg Pro Cys Asp Arg Leu Leu Arg Cys Gly Cys Leu Gly Leu
410                 415                 420                 425
 
ggc ata act aca gct tcc tcc gtg tgt gtc ccc aca tat gtt ggg agc   1348
Gly Ile Thr Thr Ala Ser Ser Val Cys Val Pro Thr Tyr Val Gly Ser
                430                 435                 440
 
tgg gag gga ctg agt tag ggtgcacggg gcggccagtc tcaccactga          1396
Trp Glu Gly Leu Ser  *
            445
 
ccagtttgtc tgtctgtgtg tgtccatgtg cgagggcaga ggaggacccc acatggaccg 1456
cagcagcgcc cgaggccagg tatacggaca tcatcctgta cgcgtcgggc tccctggcct 1516
tggctgtgct cctgctgctg gccgggctgt atcgagggca ggcgctccac ggccggcacc 1576
cccgcccgcc cgccactgtg cagaagctct cccgcttccc tctggcccga cagttctccc 1636
tggagtcagg ctcttccggc aagtcaagct catccctggt acgaggcgtg cgtctctcct 1696
ccagcggccc cgccttgctc gccggcctcg tgagtctaga tctacctctc gacccactat 1756
gggagttccc ccgggacag                                              1775

<210> 185
<211> 446
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR002A10

<400> 185
Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly
 1               5                  10                  15      
Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro
            20                  25                  30          
Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala
        35                  40                  45              
Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly
    50                  55                  60                  
His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg
65                  70                  75                  80  
Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala
                85                  90                  95      
Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn
            100                 105                 110         
Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu
        115                 120                 125             
Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln
    130                 135                 140                 
Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His
145                 150                 155                 160 
Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly
                165                 170                 175     
Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His
            180                 185                 190         
Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser
        195                 200                 205             
Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys
    210                 215                 220                 
Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp
225                 230                 235                 240 
Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro
                245                 250                 255     
Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys
            260                 265                 270         
Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val
        275                 280                 285             
Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val
    290                 295                 300                 
Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu
305                 310                 315                 320 
Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly
                325                 330                 335     
Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro
            340                 345                 350         
Gly Glu His Leu Lys Gly Gln Glu Met Leu Arg Asp Ala Pro Leu Gly
        355                 360                 365             
Gln Gln Trp Gly Leu Trp Pro Val Gly Trp Ser Val Ser Val Gly Leu
    370                 375                 380                 
Trp Gly Leu Ala Trp Gly Ala Val Cys Gly Phe Val Gly Leu Ser Cys
385                 390                 395                 400 
Met Thr Ala Pro Leu Cys Leu Ser Thr Arg Gly Arg Pro Cys Asp Arg
                405                 410                 415     
Leu Leu Arg Cys Gly Cys Leu Gly Leu Gly Ile Thr Thr Ala Ser Ser
            420                 425                 430         
Val Cys Val Pro Thr Tyr Val Gly Ser Trp Glu Gly Leu Ser
        435                 440                 445     

<210> 186
<211> 209
<212> PRT
<213> Homo sapiens

<220> 
<223> FGFR4.d BUILD 31

<400> 186
Met Met Arg Thr Pro Ser Pro Ile Gly Thr Pro Arg Ile Gly Thr Val
 1               5                  10                  15      
Thr Pro Ser Lys Val Ser Arg Ser Pro Arg Thr Cys Val Pro Ala Ala
            20                  25                  30          
Ala His Leu Ile Thr Glu Lys Arg Arg Pro Val Trp Glu His Thr Val
        35                  40                  45              
Ile Leu Gly Ala Phe Pro Cys Pro Pro Ala Pro Tyr Trp Thr His Pro
    50                  55                  60                  
Gln Arg Met Glu Lys Lys Leu His Ala Val Pro Ala Gly Asn Thr Val
65                  70                  75                  80  
Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Thr Ile Arg Trp
                85                  90                  95      
Leu Lys Asp Gly Gln Ala Phe His Gly Glu Asn Arg Ile Gly Gly Ile
            100                 105                 110         
Arg Leu Arg His Gln His Trp Ser Leu Val Met Glu Ser Val Val Pro
        115                 120                 125             
Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn Ala Val Gly Ser
    130                 135                 140                 
Ile Arg Tyr Asn Tyr Leu Leu Asp Val Leu Glu Arg Ser Pro His Arg
145                 150                 155                 160 
Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr Ala Val Val Gly
                165                 170                 175     
Ser Asp Val Glu Leu Leu Cys Lys Val Tyr Ser Asp Ala Gln Pro His
            180                 185                 190         
Ile Gln Trp Leu Lys His Ile Val Ile Asn Gly Ser Ser Phe Gly Ala
        195                 200                 205             
Asp
    
<210> 187
<211> 1240
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR020C10

<400> 187
atgaaggccc ccgctgtgct tgcacctggc atcctcgtgc tcctgtttac cttggtgcag 60
aggagcaatg gggagtgtaa agaggcacta gcaaagtccg agatgaatgt gaatatgaag 120
tatcagcttc ccaacttcac cgcggaaaca cccatccaga atgtcattct acatgagcat 180
cacattttcc ttggtgccac taactacatt tatgttttaa atgaggaaga ccttcagaag 240
gttgctgagt acaagactgg gcctgtgctg gaacacccag attgtttccc atgtcaggac 300
tgcagcagca aagccaattt atcaggaggt gtttggaaag ataacatcaa catggctcta 360
gttgtcgaca cctactatga tgatcaactc attagctgtg gcagcgtcaa cagagggacc 420
tgccagcgac atgtctttcc ccacaatcat actgctgata tacagtcgga ggttcactgc 480
atattctccc cacagataga agagcccagc cagtgtcctg actgtgtggt gagcgccctg 540
ggagccaaag tcctttcatc tgtaaaggac cggttcatca acttctttgt aggcaatacc 600
ataaattctt cttatttccc agatcatcca ttgcattcga tatcagtgag aaggctaaag 660
gaaacgaaag atggttttat gtttttgacg gaccagtcct acattgatgt tttacctgag 720
ttcagagatt cttaccccat taagtatgtc catgcctttg aaagcaacaa ttttatttac 780
ttcttgacgg tccaaaggga aactctagat gctcagactt ttcacacaag aataatcagg 840
ttctgttcca taaactctgg attgcattcc tacatggaaa tgcctctgga gtgtattctc 900
acagaaaaga gaaaaaagag atccacaaag aaggaagtgt taaatatact tcaggctgcg 960
tatgtcagca agcctggggc ccagcttgct aggcaaatag gagccagcct gaatgatgac 1020
attcttttcg gggtgttcgc acaaagcaag ccagattctg ccgaaccaat ggatcgatct 1080
gccatgtgtg cattccctat caaatatgtc aacgacttct tcaacaagat cgtcaacaaa 1140
aacaatgtga gatgtctcca gcatttttac ggacccaatc atgagcactg ctttaatagg 1200
gtaagtcaca tcagttcccc acttataaac tgtgaggtat                       1240

<210> 188
<211> 413
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR020C10

<400> 188
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Leu Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Val Ser His Ile Ser Ser Pro Leu Ile Asn Cys Glu Val
                405                 410             

<210> 189
<211> 1405
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR020C12

<400> 189
atgaaggccc ccgctgtgct tgcacctggc atcctcgtgc tcctgtttac cttggtgcag 60
aggagcaatg gggagtgtaa agaggcacta gcaaagtccg agatgaatgt gaatatgaag 120
tatcagcttc ccaacttcac cgcggaaaca cccatccaga atgtcattct acatgagcat 180
cacattttcc ttggtgccac taactacatt tatgttttaa atgaggaaga ccttcagaag 240
gttgctgagt acaagactgg gcctgtgctg gaacacccag attgtttccc atgtcaggac 300
tgcagcagca aagccaattt atcaggaggt gtttggaaaa ataacatcaa catggctcta 360
gttgtcgaca cctactatga tgatcaactc attagctgtg gcagcgtcaa cagagggacc 420
tgccagcgac atgtctttcc ccacaatcat actgctgaca tacagtcgga ggttcactgc 480
atattctccc cacagataga agagcccagc cagtgtcctg actgtgtggt gagcgccctg 540
ggagccaaag tcctttcatc tgtaaaggac cggttcatca acttctttgt aggcaatacc 600
ataaattctt cttatttccc agatcatcca ttgcattcga tatcagtgag aaggctaaag 660
gaaacgaaag atggttttat gtttttgacg gaccagtcct acattgatgt tttacctgag 720
ttcagagatt cttaccccat taagtatgtc catgcctttg aaagcaacaa ttttatttac 780
ttcttgacgg tccaaaggga aactctagat gctcagactt ttcacacaag aataatcagg 840
ttctgttcca taaactctgg attgcattcc tacatggaaa tgcctctgga gtgtattctc 900
acagaaaaga gaaaaaagag atccacaaag aaggaagtgt ttaatatact tcaggctgcg 960
tatgtcagca agcctggggc ccagcttgct agacaaatag gagccagcct gaatgatgac 1020
attcttttcg gggtgttcgc acaaagcaag ccagattctg ccgaaccaat ggatcgatct 1080
gccatgtgtg cattccctat caaatatgtc aacgacttct tcaacaagat cgtcaacaaa 1140
aacaatgtga gatgtctcca gcatttttac ggacccaatc atgagcactg ctttaatagg 1200
acacttctga gaaattcatc aggctgtgaa gcgcgccgtg atgaatatcg aacagagttt 1260
accacagctt tgcagcgcgt tgacttattc atgggtcaat tcagcgaagt cctcttaaca 1320
tctatatcca ccttcattaa aggagacctc accatagcta atcttgggac atcagagggt 1380
cgcttcatgc aggtaagtgc tttct                                       1405

<210> 190
<211> 468
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR020C12

<400> 190
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asn Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Ser Ala Phe
465             

<210> 191
<211> 1557
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR020D04

<400> 191
atgaaggccc ccgctgtgct tgcacctggc atcctcgtgc tcctgtttac cttggtgcag 60
aggagcaatg gggagtgtaa agaggcacta gcaaagtccg agatgaatgt gaatatgaag 120
tatcagcttc ccaacttcac cgcggaaaca cccatccaga atgtcattct acatgagcat 180
cacattttcc ttggtgccac taactacatt tatgttttaa atgaggaaga ccttcagaag 240
gttgctgagt acaagactgg gcctgtgctg gaacacccag attgtttccc atgtcaggac 300
tgcagcagca aagccaattt atcaggaggt gtttggaaag ataacattaa catggctcta 360
gttgtcgaca cctactatga tgatcaactc attagctgtg gcagcgtcaa cagagggacc 420
tgccagcgac atgtctttcc ccacaatcat actgctgaca tacagtcgga ggttcactgc 480
atattctccc cacagataga agagcccagc cagtgtcctg actgtgtggt gagcgccctg 540
ggagccaaag tcctttcatc tgtaaaggac cggttcatca acttctttgt aggcaatacc 600
ataaattctt cttatttccc agatcatcca ttgcattcga tatcagtgag aaggctaaag 660
gaaacgaaag atggttttat gtttttgacg gaccagtcct acattgatgt tttacctgag 720
ttcagagatt cttaccccat taagtatgtc catgcctttg aaagcaacaa ttttatttac 780
ttcttgacgg tccaaaggga aactctagat gctcagactt ttcacacaag aataatcagg 840
ttctgttcca taaactctgg attgcattcc tacatggaaa tgcctctgga gtgtattctc 900
acagaaaaga gaaaaaagag atccacaaag aaggaagtgt ttaatatact tcaggctgcg 960
tatgtcagca agcctggggc ccagcttgct agacaaatag gagccagcct gaatgatgtc 1020
attcttttcg gggtgttcgc acaaagcaag ccagattctg ccgaaccaat ggatcgatct 1080
gccatgtgtg cattccctat caaatatgtc aacgacttct tcaacaagat cgtcaacaaa 1140
aacaatgtga gatgtctcca gcatttttac ggacccaatc atgagcactg ctttaatagg 1200
acacttctga gaaattcatc aggctgtgaa gcgcgccgtg atgaatatcg aacagagttt 1260
accacagctt tgcagcgcgt tgacttattc atgggtcaat tcagcgaagt cctcttaaca 1320
tctatatcca ccttcattaa aggagacctc accatagcta atcttgggac atcagagggt 1380
cgcttcatgc aggttgtggt ttctcgatca ggaccatcaa cccctcatgt gaattttctc 1440
ctggactccc atccagtgtc tccagaagtg attgtggagc atacattaaa ccaaaatgac 1500
tacacactgg ttatcactgg gaaggaggta agctgttccc acagggaatt tccatga    1557

<210> 192
<211> 518
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR020D04

<400> 192
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Val Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480 
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Asp Tyr Thr Leu Val Ile Thr Gly Lys Glu Val Ser Cys
            500                 505                 510         
Ser His Arg Glu Phe Pro
        515             

<210> 193
<211> 1789
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR020D07

<400> 193
atgaaggccc ccgctgtgct tgcacctggc atcctcgtgc tcctgtttac cttggtgcag 60
aggagcaatg gggagtgtaa agaggcacta gcaaagtccg agatgaatgt gaatatgaag 120
tatcagcttc ccaacttcac cgcggaaaca cccatccaga atgtcattct acatgagcat 180
cacattttcc ttggtgccac taactacatt tatgttttaa atgaggaaga ccttcagaag 240
gttgctgagt acaagactgg gcctgtgctg gaacacccag attgtttccc atgtcaggac 300
tgcagcagca aagccaattt atcaggaggt gtttggaaag ataacatcaa catggctcta 360
gttgtcgaca cctactatga tgatcaactc attagctgtg gcagcgtcaa cagagggacc 420
tgccagcgac atgtctttcc ccacaatcat actgctgaca tacagtcgga ggttcactgc 480
atattctccc cacagataga agagcccagc cagtgtcctg actgtgtggt gagcgccctg 540
ggagccaaag tcctttcatc tgtaaaggac cggttcatca acttctttgt aggcaatacc 600
ataaattctt cttatttccc agatcatcca ttgcattcga tatcagtgag aaggctaaag 660
gaaacgaaag atggttttat gtttttgacg gaccagtcct acattgatgt tttacctgag 720
ttcagagatt cttaccccat taagtatgtc catgcctttg aaagcaacaa ttttatttac 780
ttcttgacgg tccaaaggga aactctagat gctcagactt ttcacacaag aataatcagg 840
ttctgttcca taaactctgg attgcattcc tacatggaaa tgcctctgga gtgtattctc 900
acagaaaaga gaaaaaagag atccacaaag aaggaagtgt ttaatatact tcaggctgcg 960
tatgtcagca agcctggggc ccagcttgct agacaaatag gagccagccc gaatgatgac 1020
attcttttcg gggtgttcgc acaaagcaag ccagattctg ccgaaccaat ggatcgatct 1080
gccatgtgtg cattccctat caaatatgtc aacgacttct tcaacaagat cgtcaacaaa 1140
aacaatgtga gatgtctcca gcatttttac ggacccaatc atgagcactg ctttaatagg 1200
acacttctga gaaattcatc aggctgtgaa gcgcgccgtg atgaatatcg aacagagttt 1260
accacagctt tgcagcgcgt tgacttattc atgggtcaat tcagcgaagt cctcttaaca 1320
tctatatcca ccttcattaa aggagacctc accatagcta atcttgggac atcagagggt 1380
cgcttcatgc aggttgtggt ttctcgatca ggaccatcaa cccctcatgt gaattttctc 1440
ctggactccc atccagtgtc tccagaagtg attgtggagc atacattaaa ccaaaatggc 1500
tacacactgg ttatcactgg gaagaagatc acgaagatcc cattgaatgg cttgggctgc 1560
agacatttcc agtcctgcag tcaatgcctc tctgccccac cctttgttca gtgtggctgg 1620
tgccacgaca aatgtgtgcg atcggaggaa tgcctgagcg ggacatggac tcaacagatc 1680
tgtctgcctg caatctacaa ggtaggaatc tctaacagct ggcatacatg tttttgtttg 1740
gtgttttttt tttttttttg gtttggtttg gtttgttttt tgttttttt             1789

<210> 194
<211> 596
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR020D07

<400> 194
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Pro Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480 
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510         
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525             
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540                 
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560 
Cys Leu Pro Ala Ile Tyr Lys Val Gly Ile Ser Asn Ser Trp His Thr
                565                 570                 575     
Cys Phe Cys Leu Val Phe Phe Phe Phe Phe Trp Phe Gly Leu Val Cys
            580                 585                 590         
Phe Leu Phe Phe
        595     

<210> 195
<211> 1936
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR020D11

<400> 195
atgaaggccc ccgctgtgct tgcacctggc atcctcgtgc tcctgtttac cttggtgcag 60
aggagcaatg gggagtgtaa agaggcacta gcaaagtccg agatgaatgt gaatatgaag 120
tatcggcttc ccaacttcac cgcggaaaca cccatccaga atgtcattct acatgagcat 180
cacattttcc ttggtgccac taactacatt tatgttttaa atgaggaaga ccttcagaag 240
gttgctgagt acaagactgg gcctgtgctg gaacacccag attgtttccc atgtcaggac 300
tgcagcagca aagccaattt atcaggaggt gtttggagag ataacatcaa catggctcta 360
gttgtcgaca cctactatga tgatcaactc attagctgtg gcagcgtcaa cagagggacc 420
tgccagcgac atgcctttcc ccacaatcat actgctgaca tacagtcgga ggttcactgc 480
atattctccc cacagataga agatcccagc cagtgtcctg actgtgtggt gagcgccctg 540
ggagccaaag tcctttcatc tgtaaaggac cggttcatca acttctttgt aggcaatacc 600
ataaattctt cttatttccc agatcatcca ttgcattcga tatcattgag aaggctaaag 660
gaaacgaaag atggttttat gtttttgacg gaccagtcct acattgatgt tttacctgag 720
ttcagagatt cttaccccat taagtatgtc catgcctttg aaagcaacaa ttttatttac 780
ttcttgacgg tccaaaggga aactctagat gctcagactt ttcacgcaag aataatcagg 840
ttctgttcca taaactctgg attgcattcc tacatggaaa tgcctctgga gtgtattctc 900
acagagaaga gaaaaaagag atccacaaag aaggaagtgt ttaatatact tcaggctgcg 960
tatgtcagca agcctggggc ccagcttgct agacaaatag gagccagcct gaatgatgac 1020
attcttttcg gggtgttcgc acaaagcaag ccagattctg ccgaaccaat ggatcgatct 1080
gccatgtgtg cattccctat caaatatgtc aacgacttct tcaacaagat cgtcaacaaa 1140
aacaatgtga gatgtctcca gcatttttac ggacccaatc atgagcactg ctttaatagg 1200
gcagaaaatg tgctagattg gaggtgaaga ccctggagcc agagagccta ggcttagtcc 1260
tagccctgca ctgaagacac ttctgagaaa ttcatcaggc tgtgaagcgc gccgtgatga 1320
atatcgaaca gagtttacca cagctttgca gcgcgttgac ttattcatgg gtcaattcag 1380
cgaagtcctc ttaacatcta tatccacctt cattaaagga gacctcacca tagctaatct 1440
tgggacatca gagggtcgct tcatgcaggt tgtggtttct cgatcaggac catcaacccc 1500
tcatgtgaat tttctcctgg actcccatcc agtgtctcca gaagtgattg tggagcatac 1560
attaaaccaa aatggctaca cactggttat cactgggaag aagatcacga agatcccatt 1620
gaatggcttg ggctgcagac atttccagtc ctgcagtcaa tgcctctctg ccccaccctt 1680
tgttcagtgt ggctggtgcc acaacaaatg tgtgcgatcg gaggaatgcc tgagcgggac 1740
atggactcaa cagatctgtc tgcctgcaat ctacaaggta ggaatctcta acagctggca 1800
tacatgtttt tgtttggtgt tttttttttt tttttggttt ggtttggttt gttttttgtt 1860
tttttagata caaatcccac taatgaaaaa aatttaaaaa tcaatttact catttagctg 1920
tgagtcatca gctaaa                                                 1936

<210> 196
<211> 408
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR020D11

<400> 196
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Arg Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Arg Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Ala Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Asp Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Leu Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Ala Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Ala Glu Asn Val Leu Asp Trp Arg
                405             

<210> 197
<211> 1888
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR020E11

<400> 197
atgaaggccc ccgctgtgct tgcacctggc atcctcgtgc tcctgtttac cttggtgcag 60
aggagcaatg gggagtgtaa agaggcacta gcaaagtccg agatgaatgt gaatatgaag 120
tatcagcttc ccaacttcac cgcggaaaca cccatccaga atgtcattct acatgagcat 180
cacattttcc ttggtgccac taactacatt tatgttttaa atgaggaaga ccttcagaag 240
gttgctgagt acaagactgg gcctgtgctg gaacacccag attgtttccc atgtcaggac 300
tgcagcagca aagccaattt atcaggaggt gtttggaaag ataacatcaa catggctcta 360
gttgtcgaca cctactatga tgatcaactc attagctgtg gcagcgtcaa cagagggacc 420
tgccagcgac atgtctttcc ccacaatcat actgctgaca tacagtcgga ggctcactgc 480
atattctccc cacagataga agagcccagt cagtgtcctg actgtgtggt gagcgccctg 540
ggagccaaag tcctttcatc tgtaaaggac cggttcatca acttctttgt aggcaatacc 600
ataaattctt cttatttccc agatcatcca ttgcattcga tatcagtgag aaggctaaag 660
gaaacgaaag atggttttat gtttttgacg gaccagtcct acattgatgt tttacctgag 720
ttcagagatt cttaccccat taagtatgtc catgcctttg aaagcaacaa ttttatttac 780
ttcttgacgg tccaaaggga aactctagat gctcagactt ttcacacaag aataatcagg 840
ttctgttcca taaactctgg attgcattcc tacatggaaa tgcctctgga gtgtattctc 900
acagaaaaga gaaaaaagag atccacaaag aaggaagtgt ttaatatact tcaggctgcg 960
tatgtcagca agcctggggc ccagcttgct agacaaatag gagccagcct gaatgatgac 1020
attcttttcg gggtgttcgc acaaagcaag ccagattctg ccgaaccaat ggatcgatct 1080
gccatgtgtg cattccctat caaatatgtc aacgacttct tcaacaagat cgtcaacaaa 1140
aacaatgtga gatgtctcca gcatttttac ggacccaatc atgagcactg ctttaatagg 1200
acacttctga gaaattcatc aggctgtgaa gcgcgccgtg atgaatatcg aacagagttt 1260
accacagctt tgcagcgcgt tgacttattc atgggtcaat tcagcgaagt cctcttaaca 1320
tctatatcca ccttcattaa aggagacctc accatagcta atcttgggac atcagagggt 1380
cgcttcatgc aggttgtggt ttctcgatca ggaccatcaa cccctcatgt gaattttctc 1440
ctggactccc atccagtgtc tccagaagtg attgtggagc atacattaaa ccaaaatggc 1500
tacacactgg ttatcactgg gaagaagatc acgaagatcc cattgaatgg cttgggctgc 1560
agacatttcc agtcctgcag tcaatgcctc tctgccccac cctttgttca gtgtggctgg 1620
tgccacgaca aatgtgtgcg atcggaggaa tgcctgagcg ggacatggac tcaacagatc 1680
tgtctgcctg caatctacaa ggttttccca aatagtgcac cccttgaagg agggacaagg 1740
ctgaccatat gtggctggga ctttggattt cggaggaata ataaatttga tttaaagaaa 1800
actagagttc tccttggaaa tgagagctgc accttgactt taagtgagag cacgatgaat 1860
acgtaaggat cttaaaatgc tttgctgg                                    1888

<210> 198
<211> 621
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR020E11

<400> 198
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Ala His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480 
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510         
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525             
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540                 
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560 
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575     
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590         
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605             
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr
    610                 615                 620     

<210> 199
<211> 1995
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR020F08

<400> 199
atgaaggccc ccgctgtgct tgcacctggc atcctcgtgc tcctgtttac cttggtgcag 60
aggagcaatg gggagtgtaa agaggcacta gcaaagtccg agatgaatgt gaatatgaag 120
tatcagcttc ccaacttcac cgcggaaaca cccatccaga atgtcattct acatgagcat 180
cacattttcc ttggtgccac taactacatt tatgttttaa atgaggaaga ccttcagaag 240
gttgctgagt acaagactgg gcctgtgctg gaacacccag attgtttccc atgtcaggac 300
tgcagcagca aagccaattt atcaggaggt gtttggaaag ataacatcaa catggctcta 360
gttgtcgaca cctactatga tgatcaactc attagctgtg gcagcgtcaa cagagggacc 420
tgccagcgac atgtctttcc ccacaatcat actgctgaca tacagtcgga ggttcactgc 480
atattctccc cacagataga agagcccagc cagtgtcctg actgtgtggt gagcgccctg 540
ggagccaaag tcctttcatc tgtaaaggac cggttcatca acttctttgt aggcaatacc 600
ataaattctt cttatttccc agatcatcca ttgcattcga tatcagtgag aaggctaaag 660
gaaacgaaag atggttttat gtttttgacg gaccagtcct acattgatgt tttacctgag 720
ttcagagatt cttaccccat taagtatgtc catgcctttg aaagcaacaa ttttatttac 780
ttcttgacgg tccaaaggga aactctagat gctcagactt ttcacacaag aataatcagg 840
ttctgttcca taaactctgg attgcattcc tacatggaaa tgcctctgga gtgtattctc 900
acagaaaaga gaaaaaagag atccacaaag aaggaagtgt ttaatatact tcaggctgcg 960
tatgtcagca agcctggggc ccagcttgct agacaaatag gagccagcct gaatgatgac 1020
attcttttcg gggtgttcgc acaaagcaag ccagattctg ccgaaccaat ggatcgatct 1080
gccatgtgtg cattccctat caaatatgtc aacgacttct tcaacaagat cgtcaacaaa 1140
aacaatgtga gatgtctcca gcatttttac ggacccaatc atgagcactg ctttaatagg 1200
acacttctga gaaattcatc aggctgtgaa gcgcgccgtg atgaatatcg aacagagttt 1260
accacagctt tgcagcgcgt tgacttattc atgggtcaat tcagcgaagt cctcttaaca 1320
tctatatcca ccttcattaa aggagacctc accatagcta atcttgggac atcagagggt 1380
cgcttcatgc aggttgtggt ttctcgatca ggaccatcaa cccctcatgt gaattttctc 1440
atggactccc atccagtgtc tccagaagtg attgtggagc atacattaaa ccaaaatggc 1500
tacacactgg ttatcactgg gaagaagatc acgaagatcc cattgaatgg cttgggctgc 1560
agacatttcc agtcctgcag tcaatgcctc tctgccccac cctttgttca gtgtggctgg 1620
tgccacgaca aatgtgtgcg atcggaggaa tgcctgagcg ggacatggac tcaacagatc 1680
tgtctgcctg caatctacaa ggttttccca aatagtgcac cccttgaagg agggacaagg 1740
ctgaccatat gtggctggga ctttggattt cggaggaata ataaatttga tttaaagaaa 1800
actagagttc tccttggaaa tgagagctgc accttgactt taagtgagag cacgatgaat 1860
acattgaaat gcacagttgg tcctgccatg aataagcatt tcaatatgtc cataattatt 1920
tcaaatggcc acgggacaac acaatacagt acattctcct atgtggtaag gaagattcta 1980
tcctatcatg tttga                                                  1995

<210> 200
<211> 664
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR020F08

<400> 200
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480 
Met Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510         
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525             
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540                 
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560 
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575     
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590         
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605             
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620                 
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640 
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Val
                645                 650                 655     
Arg Lys Ile Leu Ser Tyr His Val
            660                 

<210> 201
<211> 2170
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR020F11

<400> 201
atgaaggccc ccgctgtgct tgcacctggc atcctcgtgc tcctgtttac cctggtgcag 60
aggagcaatg gggagtgtaa agaggcacta gcaaagtccg agatgaatgt gaatatgaag 120
tatcagcttc ccaacttcac cgcggaaaca cccatccaga atgtcattct acatgagcat 180
cacattttcc ttggtgccac taactacatt tatgttttaa atgaggaaga ccttcagaag 240
gttgctgagt acaagactgg gcctgtgctg gaacacccag attgtttccc atgtcaggac 300
tgcagcagca aagccaattt atcaggaggt gtttggaaag ataacatcaa catggctcta 360
gttgtcgaca cctactatga tgatcaactc attagctgtg gcagcgtcaa cagagggacc 420
tgccagcgac atgtctttcc ccacaatcat cctgctgaca tacagtcgga ggttcactgc 480
atattctccc cacagataga agagcccagc cagtgtcctg actgtgtggt gagcgccctg 540
ggagccaaag tcctttcatc tgtaaaggac cggttcatca acttctttgt aggcaatacc 600
ataaattctt cttatttccc agatcatcca ttgcattcga tatcagtgag aaggctaaag 660
gaaacgaaag atggttttat gtttttgacg gaccagtcct acattgatgt tttacctgag 720
ttcagagatt cttaccccat taagtatgtc catgcctttg aaagcaacaa ttttatttac 780
ttcttgacgg tccaaaggga aactctagat gctcagactt ttcacacaag aataatcagg 840
ttctgttcca taaactctgg attgcattcc tacatggaaa tgcctctgga gtgtattctc 900
acagaaaaga gaaaaaagag atccacaaag aaggaagtgt ttaatatact tcaggctgcg 960
tatgttagca agcctggggc ccagcttgct agacaaatag gagccagcct gaatgatgac 1020
attcttttcg gggtgttcgc acaaagcaag ccagattctg ccgaaccaat ggatcgatct 1080
gccatgtgtg cattccctat caaatatgtc aacgacttct tcaacaagat cgtcaacaaa 1140
aacaatgtga gatgtctcca gcatttttac ggacccaatc atgagcactg ctttaatagg 1200
acacttctga gaaattcatc aggctgtgaa gcgcgccgtg atgaatatcg aacagagttt 1260
accacagctt tgcagcgcgt tgacttattc atgggtcaat tcagcgaagt cctcttaaca 1320
tctatatcca ccttcattaa aggagacctc accatagcta atcttgggac atcagagggt 1380
cgcttcatgc aggttgtggt ttctcgatca ggaccatcaa cccctcatgt gaattttctc 1440
ctggactccc atccagtgtc tccagaagtg attgtggagc atacattaaa ccaaaatggc 1500
cacacactgg ttatcactgg gaagaagatc acgaagatcc cattgaatgg cttgggctgc 1560
agacatttcc agtcctgcag tcaatgcctc tctgccccac cctttgttca gtgtggctgg 1620
tgccacgaca aatgtgtgcg atcggaggaa tgcctgagcg ggacatggac tcaacagatc 1680
tgtctgcctg caatctacaa ggttttccca aatagtgcac cccttgaagg agggacaagg 1740
ctgaccatat gtggctggga ctttggattt cggaggaata ataaatttga tttaaagaaa 1800
actagagttc tccttggaaa tgagagctgc accttgactt taagtgagag cacgatgaat 1860
acattgaaat gcacagttgg tcctgccatg aataagcatt tcaatatgtc cataattatt 1920
tcaaatggcc acgggacaac acaatacagt acattctcct atgtggatcc tgtaataaca 1980
agtatttcgc cgaaatacgg tcctatggct ggtggcactt tacttacttt aactggaaat 2040
tacctaaaca gtgggaattc tagacacatt tcaattggtg gaaaaacatg tactttaaaa 2100
aggtgttgta aatttatttt ttgttgcatc tgtcaatttg aattaatatc tgtaccttaa 2160
aaattaagca                                                        2170

<210> 202
<211> 719
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR020F11

<400> 202
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Pro Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480 
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Gly His Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510         
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525             
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540                 
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560 
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575     
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590         
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605             
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620                 
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640 
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
                645                 650                 655     
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly
            660                 665                 670         
Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg
        675                 680                 685             
His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Arg Cys Cys Lys
    690                 695                 700                 
Phe Ile Phe Cys Cys Ile Cys Gln Phe Glu Leu Ile Ser Val Pro
705                 710                 715                 

<210> 203
<211> 2194
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR020F12

<400> 203
atgaaggccc ccgctgtgct tgcacctggc atcctcgtgc tcctgtttac cttggtgcag 60
aggagcaatg gggagtgtaa agaggcacta gcaaagtccg agatgaatgc gaatatgaag 120
tatcagcttc ccaacttcac cgcggaaaca cccatccaga atgtcattct acatgagcat 180
cacattttcc ttggtgccac taactacatt tatgttttaa atgaggaaga ccttcagaag 240
gttgctgagt acaagactgg gcctgtgctg gaacacccag attgtttccc atgtcaggac 300
tgcagcagca aagccaattt atcaggaggt gtttggaaag ataacatcaa catggctcta 360
gttgtcgaca cctactatga tgatcaactc attagctgtg gcagcgtcaa cagagggacc 420
tgccagcgac atgtctttcc ccacaatcat actgctgaca tacagtcgga ggttcactgc 480
atattctccc cacagataga agagcccagc cagtgtcctg actgtgtggt gagcgccctg 540
ggagccaaag tcctttcatc tgtaaaggac cggttcatca acttctttgt aggcaatacc 600
ataaattctt cttatttccc agatcatcca ttgcattcga tatcagtgag gaggctaaag 660
gaaacgaaag atggttttat gtttttgacg gaccagtcct acattgatgt tttacctgag 720
ttcagagatt cttaccccat taagtatgtc catgcctttg aaagcaacaa ttttatttac 780
ttcttgacgg tccaaaggga aactctagat gctcagactt ttcacacaag aataatcagg 840
ttctgttcca taaactctgg attgcattcc tacatggaaa tgcctctgga gtgtattctc 900
acagaaaaga gaaaaaagag atccacaaag aaggaagtgt ttaatatact tcaggctgcg 960
tatgtcagca agcctggggc ccagcttgct agacaaatag gagccagcct gaatgatgac 1020
attcttttcg gggtgttcgc acaaagcaag ccagattctg ccgaaccaat ggatcgatct 1080
gccatgtgtg cattccctat caaatatgtc aacgacttct tcaacaagat cgtcaacaaa 1140
aacaatgtga gatgtctcca gcatttttac ggacccaatc atgagcactg ctttaatagg 1200
acacttctga gaaattcatc aggctgtgaa gcgcgccgtg atgaatatcg aacagagttt 1260
accacagctt tgcagcgcgt tgacttattc atgggtcaat tcagcgaagt cctcttaaca 1320
tctatatcca ccttcattaa aggagacctc accatagcta atcttgggac atcagagggt 1380
cgcttcatgc aggttgtggt ttctcgatca ggaccatcaa cccctcatgt gaattttctc 1440
ctggactccc atccagtgtc tccagaagtg attgtggagc atacattaaa ccaaaatggc 1500
tacacactgg ttatcactgg gaagaagatc acgaagaccc cattgaatgg cttgggctgc 1560
agacatttcc agtcctgcag tcaatgcctc tctgccccac cctttgttca gtgtggctgg 1620
tgccacgaca aatgtgtgcg atcggaggaa tgcctgagcg ggacatggac tcaacagatc 1680
tgtctgcctg caatctacaa ggttttccca aatagtgcac cccttgaagg agggacaagg 1740
ctgaccatat gtggctggga ctttggattt cggaggaata ataaatttga tttaaagaaa 1800
actagagttc tccttggaaa tgagagctgc accttgactt taagtgagag cacgatgaat 1860
acattgaaat gcacagttgg tcctgccatg aataagcatt tcaatatgtc cataattatt 1920
tcaaatggcc acgggacaac acagtacagt acattctcct atgtgttact ttgttttgtt 1980
tttatctccc ctccaggatc ctgtaataac aagtatttcg ccgaaatacg gtcctatggc 2040
tggtggcact ttacttactt taactggaaa ttacctaaac agtgggaatt ctagacacat 2100
ttcaattggt ggaaaaacat gtactttaaa aaggtgttgt aaatttattt tttgttgcat 2160
ctgtcaattt gaattaatat ctgtacctta aaaa                             2194

<210> 204
<211> 697
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR020F12

<400> 204
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Ala Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480 
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510         
Thr Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525             
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540                 
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560 
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575     
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590         
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605             
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620                 
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640 
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Leu
                645                 650                 655     
Leu Cys Phe Val Phe Ile Ser Pro Pro Gly Ser Cys Asn Asn Lys Tyr
            660                 665                 670         
Phe Ala Glu Ile Arg Ser Tyr Gly Trp Trp His Phe Thr Tyr Phe Asn
        675                 680                 685             
Trp Lys Leu Pro Lys Gln Trp Glu Phe
    690                 695         

<210> 205
<211> 2082
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR020G03

<400> 205
aatgaaggcc cccgctgtgc ttgcacctgg catcctcgtg ctcctgttta ccttggtgca 60
gaggagcaat ggggagtgta aagaggcact agcaaagtcc gagatgaatg tgaatatgaa 120
gtatcagctt cccaacttca ccgcggaaac acccatccag aatgtcattc tacatgagca 180
tcacattttc cttggtgcca ctaactacat ttatgtttta aatgaggaag accttcagaa 240
ggttgctgag tacaagactg ggcctgtgct ggaacaccca gattgtttcc catgtcagga 300
ctgcagcagc aaagccaatt tatcaggagg tgtttggaaa gataacatca acatggctct 360
agttgtcgac acctactatg atgatcaact cattagctgt ggcagcgtca acagagggac 420
ctgccagcga catgtctttc cccacaatca tactgctgac atacagtcgg aggttcactg 480
catattctcc ccacagatag aagagcccag ccagtgtcct gactgtgtgg tgagcgccct 540
gggagccaaa gtcctttcat ctgtaaagga ccggttcatc aacttctttg taggcaatac 600
cataaattct tcttatttcc cagatcatcc attgcattcg atatcagtga gaaggctaaa 660
ggaaacgaaa gatggtttta tgtttttgac ggaccagtcc tacattgatg ttttacctga 720
gttcagagat tcttacccca ttaagtatgt ccatgccttt gaaagcaaca attttattta 780
cttcttgacg gtccaaaggg aaactctaga tgctcagact tttcacacaa gaataatcag 840
gttctgttcc ataaactctg gattgcattc ctacatggaa atgcctctgg agtgtattct 900
cacagaaaag agaaaaaaga gatccacaaa gaaggaagtg tttaatatac ttcaggctgc 960
gtatgtcagc aagcctgggg cccagcttgc tagacaaata ggagccagcc tgaatgatga 1020
cattcttttc ggggtgttcg cacaaagcaa gccagattct gccgaaccaa tggatcgatc 1080
tgccatgtgt gcattcccta tcaaatatgt caacgacttc ttcaacaaga tcgtcaacaa 1140
aaacaatgtg agatgtctcc agcattttta cggacccaat catgagcact gctttaatag 1200
gacacttctg agaaattcat caggctgtga agcgcgccgt gatgaatatc gaacagagtt 1260
taccacagct ttgcagcgcg ttgacttatt catgggtcaa ttcagcgaag tcctcttaac 1320
atctatatcc accttcatta aaggagacct caccatagct aatcttggga catcagaggg 1380
tcgcttcatg caggttgtgg tttctcgatc aggaccatca acccctcatg tgaattttct 1440
cctggactcc catccagtgt ctccagaagt gattgtggag catacattaa accaaaatgg 1500
ctacacactg gttatcactg ggaagaagtg tggctggcgc cacgacaaat gtgtgcgatc 1560
ggaggaatgc ctgagcggga catggactca acagatctgt ctgcctgcaa tctacaaggt 1620
tttcccaaat agtgcacccc ttgaaggagg gacaaggctg accatatgtg gctgggactt 1680
tggatttcgg aggaataata aatttgattt aaagaaaact agagttctcc ttggaaatga 1740
gagctgcacc ttgactttaa gtgagagcac gatgaataca ttgaaatgca cagttggtcc 1800
tgccatgaat aagcatttca atatgtccat aattatttca aatggccacg ggacaacaca 1860
atacagtaca ttctcctatg tggatcctgt aataacaagt atttcgccga aatacggtcc 1920
tatggctggt ggcactttac ttactttaac tggaaattac ctaaacagtg ggaattctag 1980
acacatttca attggtggaa aaacatgtac tctaaaaagg tgtggtaaat ttattttttg 2040
ttgcatctgt caatttgaat taatatctgt accttaaaaa tt                    2082

<210> 206
<211> 691
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR020G03

<400> 206
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480 
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Cys Gly Trp
            500                 505                 510         
Arg His Asp Lys Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp
        515                 520                 525             
Thr Gln Gln Ile Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser
    530                 535                 540                 
Ala Pro Leu Glu Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe
545                 550                 555                 560 
Gly Phe Arg Arg Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu
                565                 570                 575     
Leu Gly Asn Glu Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn
            580                 585                 590         
Thr Leu Lys Cys Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met
        595                 600                 605             
Ser Ile Ile Ile Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe
    610                 615                 620                 
Ser Tyr Val Asp Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro
625                 630                 635                 640 
Met Ala Gly Gly Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser
                645                 650                 655     
Gly Asn Ser Arg His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys
            660                 665                 670         
Arg Cys Gly Lys Phe Ile Phe Cys Cys Ile Cys Gln Phe Glu Leu Ile
        675                 680                 685             
Ser Val Pro
    690     

<210> 207
<211> 2294
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR020G07

<400> 207
atgaaggccc ccgctgtgct tgcacctggc atcctcgtgc tcctgtttac cttggtgcag 60
aggagcaatg gggagtgtaa agaggcacta gcaaagtccg agatgaatgt gaatatgaag 120
tatcagcttc ccaacttcac cgcggaaaca cccatccaga atgtcattct acatgagcat 180
cacattttcc ttggtgccac taactacatt tatgttttaa atgaggaaga ccttcagaag 240
gttgctgagt acaagactgg gcctgtgctg gaacacccag attgtttccc atgtcaggac 300
tgcagcagca aagccaattt atcaggaggt gtttggaaag ataacatcaa catggctcta 360
gttgtcgaca cctactatga tgatcaactc attagctgtg gcagcgtcaa cagagggacc 420
tgccagcgac atgtctttcc ccacaatcat actgctgaca tacagtcgga ggttcactgc 480
atattctccc cacagataga agagcccagc cagtgtcctg actgtgtggt gagcgccctg 540
ggagccaaag tcctttcatc tgtaaaggac cggttcatca acttctttgt aggcaatacc 600
ataaattctt cttatttccc agatcatcca ttgcattcga tatcagtgag aaggctaaag 660
gaaacgaaag atggttttat gtttttgacg gaccagtcct acattgatgt tttacctgag 720
ttcagagatt cttaccccat taagtatgtc catgcctttg aaagcaacaa ttttatttac 780
ttcttgacgg tccaaaggga aactctagat gctcagactt ttcacacaag aataatcagg 840
ttctgttcca taaactctgg attgcattcc tacatggaaa tgcctctgga gtgtattctc 900
acagaaaaga gaaaaaagag atccacaaag aaggaagtgt ttaatatact tcaggctgcg 960
tatgtcagca agcctggggc ccagcttgct agacaaatag gagccagcct gaatgatgac 1020
attcttttcg gggtgttcgc acaaagcaag ccagattctg ccgaaccaat ggatcgatct 1080
gccatgtgtg cattccctat caaatatgtc aacgacttct tcaacaagat cgtcaacaaa 1140
aacaatgtga gatgtctcca gcatttttac ggacccaatc atgagcactg ctttaatagg 1200
acacttctga gaaattcatc aggctgtgaa gcgcgccgtg atgaatatcg aacagagttt 1260
accacagctt tgcagcgcgt tgacttattc atgggtcaat tcagcgaagt cctcttaaca 1320
tctatatcca ccttcattaa aggagacctc accatagcta atcttgggac atcagagggt 1380
cgcttcatgc aggttgtggt ttctcgatca ggaccatcaa cccctcatgt gaattttctc 1440
ctggactccc atccagtgtc tccagaagtg attgtggagc atacattaaa ccaaaatggc 1500
tacacactgg ttatcactgg gaagaagatc gcgaagatcc cattgaatgg cttgggttgc 1560
agacatttcc agtcctgcag tcaatgcctc tctgccccac cctttgttca gtgtggctgg 1620
tgccacgaca aatgtgtgcg atcggaggaa tgcctgagcg ggacatggac tcaacagatc 1680
tgtctgcctg caatctacaa ggttttccca aatagtgcac cccttgaagg agggacaagg 1740
ctgaccatat gtggctggga ctttggattt cggaggaata ataaatttga tttaaagaaa 1800
actagagttc tccttggaaa tgagagctgc accttgactt taagtgagag cacgatgaat 1860
acattgaaat gcacagttgg tcctgccatg aataagcatt tcaatatgtc cataattatt 1920
tcaaatggcc acgggacaac acagtacagt acattctcct atgtgctccc ctccaggatc 1980
ctgtaataac aagtatttcg ccgaaatacg gtcctatggc tggtggcact ttacttactt 2040
taactggaaa ttacctaaac agtgggaatt ctagacacat ttcaattggt ggaaaaacat 2100
gtactttaaa aagtgtgtca aacagtattc ttgaatgtta taccccagcc caaaccattt 2160
caactgagtt tgctgttaaa ttgaaaattg acttagccaa ccgagagaca agcatcttca 2220
gttaccgtga agatcccatt gtctatgaaa ttcatccaac caaatctttt attaggtaag 2280
tagaagcttc tgat                                                   2294

<210> 208
<211> 661
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR020G07

<400> 208
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480 
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Ala Lys
            500                 505                 510         
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525             
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540                 
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560 
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575     
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590         
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605             
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620                 
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640 
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Leu
                645                 650                 655     
Pro Ser Arg Ile Leu
            660     

<210> 209
<211> 3256
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR020H03

<400> 209
atgaaggccc ccgctgtgct tgcacctggc atcctcgtgc tcctgtttac cttggtgcag 60
aggagcaatg gggagtgtaa agaggcacta gcaaagtccg agatgaatgt gaatatgaag 120
tatcagcttc ccaacttcac cgcggaaaca cccatccaga atgtcattct acatgagcat 180
cacattttcc ttggtgccac taactacatt tatgttttaa atgaggaaga ccttcagaag 240
gttgctgagt acaagactgg gcctgtgctg gaacacccag attgtttccc atgtcaggac 300
tgcagcagca aagccaattt atcaggaggt gtttggaaag ataacatcaa catggctcta 360
gttgtcgaca cctactatga tgatcaactc attagctgtg gcagcgtcaa cagagggacc 420
tgccagcgac atgtctttcc ccacaatcat actgctgaca tacagtcgga ggttcactgc 480
atattctccc cacagataga agagcccagc cagtgtcctg actgtgtggt gagcgccctg 540
ggagccaaag tcctttcatc tgtaaaggac cggttcatca acttctttgt aggcaatacc 600
ataaattctt cttatttccc agatcatcca ttgcattcga tatcagtgag aaggctaaag 660
gaaacgaaag atggttttat gtttttgacg gaccagtcct acattgatgt tttacctgag 720
ttcagagatt cttaccccat taagtatgtc catgcctttg aaagcaacaa ttttatttac 780
ttcttgacgg tccaaaggga aactctagat gctcagactt ttcacacaag aataatcagg 840
ttctgttcca taaactctgg attgcattcc tacatggaaa tgcctctgga gtgtattctc 900
acagaaaaga gaaaaaagag atccacaaag aaggaagtgt ttaatatact tcaggctgcg 960
tatgtcagca agcctggggc ccagcttgct agacaaatag gagccagcct gaatgatgac 1020
attcttttcg gggtgttcgc acaaagcaag ccagattctg ccgaaccaat ggatcgatct 1080
gccatgtgtg cattccctat caaatatgtc aacgacttct tcaacaagat cgtcaacaaa 1140
aacgatgtga gatgtctcca gcatttttac ggacccaatc atgagcactg ctttaatggg 1200
acacttctga gaaattcatc aggctgtgaa gcgcgccgtg atgaatatcg aacagagttt 1260
accacagctt tgcagcgcgt tgacttattc atgggtcaat tcagcgaagt cctcttaaca 1320
tctatatcca ccttcattaa aggagacctc accatagcta atcttgggac atcagagggt 1380
cgcttcatgc aggttgtggt ttctcgatca ggaccatcaa cccctcgtgt gaattttctc 1440
ctggactccc atccagtgtc tccagaagtg attgtggagc atacattaaa ccaaaatggc 1500
tacacactgg ttatcactgg gaagaagatc acgaagatcc cattgaatgg tttgggctgc 1560
agacatttcc agtcctgcag tcaatgcctc tctgccccac cctttgttca gtgtggctgg 1620
tgctacgaca aatgtgtgcg atcggaggaa tgcctgagcg ggacatggac tcaacagatc 1680
tgtctgcctg caatctacaa ggttttccca aatagtgcac cccttgaagg agggacaagg 1740
ctgaccatat gtggctggga ctttggattt cggaggaata ataaatttga tttaaagaaa 1800
actagagttc tccttggaaa tgagagctgc accttgactt taagtgagag cacgatgaat 1860
acatcgaaat gcacagttgg tcctgccatg aataagcatt tcaatatgtc cataattatt 1920
tcaaatggcc acgggacaac acaatacagt acattctcct atgtggatcc tgtaataaca 1980
agtatttcgc cgaaatacgg tcctatggct ggtggcactt tacttacttt aactggaaat 2040
tacctaaaca gtgggaattc tagacacatt tcaattggtg ggaaaacatg tactttaaaa 2100
agtgtgtcaa acagtattct tgaatgttat accccagccc aaaccatttc aactgagttt 2160
gctgttaaat tgaaaattga cttagccaac cgagagacaa gcatcttcag ttaccgtgaa 2220
gatcccattg tctatgtaat tcatccaacc aaatctttta ttaggtaagt agaagcttct 2280
gatgggtata agaaaacaat gaatacaagg atgattttgc tgtagaatag tcaagaggaa 2340
ttgcagtttt atctctggct ttgatgctgt tatgttgctt ttgaaggctt ctttccaatt 2400
caggagagaa aactatattc aggttctgag tgtagtttga cttatcaatg ctagttcatt 2460
ccaagaagta tcttatcctg ttctattaca tttaaacaga gtatagcaaa atagtttaat 2520
gtggcattgt agtatacatg cacttacatt atgtacatat caattctata ctaaccttag 2580
tgcccagaag tggaattacc ttttttcttc cattctctag atatgttttt gtcctgcctg 2640
ctttacacac agcttttctt tatgccagac tctctttgaa ttgatatctc attggaccca 2700
gttcaatctg ccttgttccc gttaattcta tcagtctagc aacaatagtt aagttcggtt 2760
ttctttgtat ttttttcaga ggtgaaatat ttattttgtg taattcggtg aataaaatac 2820
aaatgcattt cttaagctta tgaaatatgc attttaaaaa tattttcaag ttaaataagt 2880
tgtttccaaa gaacagttac ccatgaactt ccatttgatg ttgactgtgc ctctgacctg 2940
taatcagtgc aggtgattaa attgaatccc tctcttacag tacttggtgg aaagaacctc 3000
tcaacattgt cagttttcta ttttgctttg ccagtggtgg gagcacaata acaggtgttg 3060
ggaaaaacct gaattcagtt agtgtcccga gaatggtcat aaatgtgcat gaagcaggaa 3120
ggaactttac agtggtaagt cctttgagca atggttctac tcagagctct gcatctttgc 3180
ctctaaccat gtggctttca tggtacctga gacatctcag tttcgccttt aaggtttgct 3240
agttaatttc cttgca                                                 3256

<210> 210
<211> 755
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR020H03

<400> 210
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asp Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Gly
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro Arg Val Asn Phe Leu
465                 470                 475                 480 
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510         
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525             
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys Tyr Asp Lys
    530                 535                 540                 
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560 
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575     
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590         
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605             
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Ser Lys Cys
    610                 615                 620                 
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640 
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
                645                 650                 655     
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly
            660                 665                 670         
Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg
        675                 680                 685             
His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn
    690                 695                 700                 
Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe
705                 710                 715                 720 
Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe
                725                 730                 735     
Ser Tyr Arg Glu Asp Pro Ile Val Tyr Val Ile His Pro Thr Lys Ser
            740                 745                 750         
Phe Ile Arg
        755

<210> 211
<211> 2481
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR020H06

<400> 211
atgaaggccc ccgctgtgct tgcacctggc atcctcgtgc tcctgtttac cttggtgcag 60
aggagcaatg gggagtgtaa agaggcacta gcaaagtccg agatgaatgt gaatacgaag 120
tatcagcttc ccaacttcac cgcggaaaca cccatccaga atgtcattct acatgagcat 180
cacattttcc ttggtgccac taactacatt tatgttttaa atgaggaaga ccttcagaag 240
gttgctgagt acaagactgg gcctgtgctg gaacacccag attgtttccc atgtcaggac 300
tgcagcagca aagccaattt atcaggaggt gtttggaaag ataacatcaa catggctcta 360
gttgtcgaca cctactatga tgatcaactc attagctgtg gcagcgtcaa cagagggacc 420
tgccagcgac atgtctttcc ccacaatcat actgctgaca tacagtcgga ggttcactgc 480
atattctccc cacagataga agagcccagc cagtgtcctg actgtgtggt gagcgccctg 540
ggagccaaag tcctttcatc tgtaaaggac cggttcatca acttctttgt aggcaatacc 600
ataaattctt cttatttccc agatcatcca ttgcattcga tatcagtgag aaggctaaag 660
gaaacgaaag atggttttat gtttttgacg gaccagtcct acattgatgt tttacctgag 720
ttcagagatt cttaccccat taagtatgtc catgcctttg aaagcaacaa ttttatttac 780
ttcttgacgg tccaaaggga aactctagat gctcagactt ttcacacaag aataatcagg 840
ttctgttcca taaactctgg attgcattcc tacatggaaa tgcctctgga gtgtattctc 900
acagaaaaga gaaaaaagag atccacaaag aaggaagtgt ttaatatact tcaggctgcg 960
tatgtcagca agcctggggc ccagcttgct agacaaatag gagccagcct gaatgatgac 1020
attcttttcg gggtgttcgc acaaagcaag ccagattctg ccgaaccaat ggatcgatct 1080
gccatgtgtg cattccctat caaatatgtc aacgacttct tcaacaagat cgtcaacaaa 1140
aacaatgtga gatgtctcca gcatttttac ggacccaatc atgagcactg ctttaatagg 1200
acacttctga gaaattcatc aggctgtgaa gcgcgccgtg atgaatatcg aacagagttt 1260
accacagctt tgcagcgcgt tgacttattc atgggtcaat tcagcgaagt cctcttaaca 1320
tctatatcca ccttcattaa aggagacctc accatagcta atcttgggac atcagagggt 1380
cgcttcatgc aggttgtggt ttctcgatca ggaccatcaa cccctcatgt gaattttctc 1440
ctggactccc atccagtgtc tccagaagtg attgtggagc atacattaaa ccaaaatggc 1500
tacacactgg ttatcactgg gaagaagatc acgaagatcc cattgaatgg cttgggctgc 1560
agacatttcc agtcctgcag tcaatgcctc tctgccccac cctttgttca gtgtggctgg 1620
tgccacgaca aatgtgtgcg atcggaggaa tgcctgagcg ggacatggac tcaacagatc 1680
tgtctgcctg caatctacaa ggttttccca aatagtgcac cccttgaagg agggacaagg 1740
ctgaccatat gtggctggga ctttggattt cggaggaata ataaatttga tttaaagaaa 1800
actagagttc tccttggaaa tgagagctgc accttgactt taagtgagag cacgatgaat 1860
acattgaaat gcacagttgg tcctgccatg aataagcatt tcaatatgtc cataattatt 1920
tcaaatggcc acgggacaac acaatacagt acattctcct atgtggatcc tgtaataaca 1980
agtatttcgc cgaaatacgg tcctatggct ggtggcactt tacttacttt aactggaaat 2040
tacctaaaca gtgggaattc tagacacatt tcaattggtg gaaaaacatg tactttaaaa 2100
agtgtgtcaa acagtattct tgaatgttat accccagccc aaaccatttc aactgagttt 2160
gctgttaaat tgaaaattga cttaaccaac cgagagacaa gcatcttcag ttaccgtgaa 2220
gatcccattg tctatgaaat tcatccaacc aaatctttta ttagtggtgg gagcacaata 2280
acaggtgttg ggaaaaacct gaattcagtt agtgtcccga gaatggtcat aaatgtgcat 2340
gaagcaggaa ggaactttac agtggtaagt cctttgagca atggttctac tcagagctct 2400
gcatctttgc ctctaaccat gtggctttca tggtacctga gacatctcag tttcgccttt 2460
aaggtttgct agttaatttc c                                           2481

<210> 212
<211> 823
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR020H06

<400> 212
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Thr Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480 
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510         
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525             
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540                 
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560 
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575     
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590         
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605             
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620                 
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640 
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
                645                 650                 655     
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly
            660                 665                 670         
Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg
        675                 680                 685             
His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn
    690                 695                 700                 
Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe
705                 710                 715                 720 
Ala Val Lys Leu Lys Ile Asp Leu Thr Asn Arg Glu Thr Ser Ile Phe
                725                 730                 735     
Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser
            740                 745                 750         
Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn
        755                 760                 765             
Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg
    770                 775                 780                 
Asn Phe Thr Val Val Ser Pro Leu Ser Asn Gly Ser Thr Gln Ser Ser
785                 790                 795                 800 
Ala Ser Leu Pro Leu Thr Met Trp Leu Ser Trp Tyr Leu Arg His Leu
                805                 810                 815     
Ser Phe Ala Phe Lys Val Cys
            820             

<210> 213
<211> 2667
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR020H07

<400> 213
atgaaggccc ccgctgtgct tgcacctggc atcctcgtgc tcctgtttac cttggtgcag 60
aggagcaatg gggagtgtaa agaggcacta gcaaagtccg agatgaatgt gaatatgaag 120
tatcagcttc ccaacttcac cgcggaaaca cccatccaga atgtcattct acatgagcat 180
cacattttcc ttggtgccac taactacatt tatgttttaa atgaggaaga ccttcagaag 240
gttgctgagt acaagactgg gcctgtgctg gaacacccag attgtttccc atgtcaggac 300
tgcagcagca aagccaattt atcaggaggt gtttggaaag ataacatcaa catggctcta 360
gttgtcgaca cctactatga tgatcaactc attagctgtg gcagcgtcaa cagagggacc 420
tgccagcgac atgtctttcc ccgcaatcat actgctgaca tacagtcgga ggttcactgc 480
atattctccc cacagataga agagcccagc cagtgtcctg actgtgtggt gagcgccctg 540
ggagccaaag tcctttcatc tgtaaaggac cggttcacca acttctttgt aggcaatacc 600
ataaattctt cttatttccc agatcatcca ttgcattcga tatcagtgag aaggctaaag 660
gaaacgaaag atggttttat gtttttgacg gaccagtcct acattgatgt tttacctgag 720
ttcagagatt cttaccccat taagtatgtc catgcctttg aaagcaacaa ttttatttac 780
ttcttgacgg tccaaaggga aactctagat gctcagactt ttcacacaag aataatcagg 840
ttctgttcca taaactctgg attgcattcc tacatggaaa tgcctctgga gtgtattctc 900
acagaaaaga gaaaaaagag atccacaaag aaggaagtgt ttaatatact tcaggctgcg 960
tatgtcagca agcctggggc ccagcttgct agacaaatag gagccagccc gaatgatgac 1020
attcttttcg gagtgttcgc acaaagcaag ccagattctg ccgaaccaat ggatcgatct 1080
gccatgtgtg cattccctat caaatatgtc aacgacttct tcaacaagat cgtcaacaaa 1140
aacaatgtga gatgtctcca gcatttttac ggacccaatc atgagcactg ctttaatagg 1200
acacttctga gaaattcatc aggctgtgaa gcgcgccgtg atgaatatcg aacagagttc 1260
accacagctt tgcagcgcgt tgacttattc atgggtcaat tcagcgaagt cctcttaaca 1320
tctatatcca ccttcattaa aggagacctc accatagcta atcttgggac atcagagggt 1380
cgcttcatgc aggttgtggt ttctcgatca ggaccatcaa cccctcatgt gaattttctc 1440
ctggactccc atccagtgtc tccagaagtg attgtggagc atacattaaa ccaaaatggc 1500
tacacactgg ttatcactgg gaagaagatc acgaagatcc cattgaatgg cttgggctgc 1560
agacatttcc agtcctgcag tcaatgcctc tctgccccac cctttgttca gtgtggctgg 1620
tgccacgaca aatgtgtgcg atcggaggaa tgcctgagcg ggacatggac tcaacagatc 1680
tgtctgcctg caatctacaa ggttttccca aatagtgcac cccttgaagg agggacaagg 1740
ctgaccatat gtggctggga ctttggattt cggaggaata ataaatttga tttaaagaaa 1800
actagagttc tccttggaaa tgagagctgc accttgactt taagtgagag cacgatgaat 1860
acattgaaat gcacagttgg tcctgccatg aataagcatt tcaatatgtc cataattatt 1920
tcaaatggcc acgggacaac acaatacagt acattctcct atgtggatcc tgtaataaca 1980
agtatttcgc cgaaatacgg tcctatggct ggtggcactt tacttacttt aactggaaat 2040
tacctaaaca gtgggaattc tagacacatt tcaattggtg gaaaaacatg tactttaaaa 2100
agtgtgtcaa acagtattct tgaatgttat accccagccc aaaccatttc aactgagttt 2160
gctgttaaat tgaaaattga cttagccaac cgagagacaa gcatcttcag ttaccgtgaa 2220
gatcccattg tctatgaaat tcatccaacc aaatctttta ttagtggtgg gagcacaata 2280
acaggtgttg ggaaaaacct gaattcagtt agtgtcccga gaatggtcat aaatgtgcat 2340
gaagcgggaa ggaactttac agtggcatgt caacatcgct ctaattcaga gataatctgt 2400
tgtaccactc cttccctgca acagctgaat ctgcaactcc ccctgaaaac caaagccttt 2460
ttcatgttag atgggatcct ttccaaatac tttgatctca tttatgtaca taatcctgtg 2520
tttaagcctt ttgaaaagcc agtgatgatc tcaatgggca atgaaaatgt actggaaatt 2580
aaggtaagaa atgctttaaa cactgtctta aatcatcagc tcaaacttaa ttgacttcat 2640
agctatgtga atacaattgt tgtactt                                     2667

<210> 214
<211> 877
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR020H07

<400> 214
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro Arg Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Thr Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Pro Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480 
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510         
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525             
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540                 
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560 
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575     
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590         
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605             
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620                 
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640 
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
                645                 650                 655     
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly
            660                 665                 670         
Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg
        675                 680                 685             
His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn
    690                 695                 700                 
Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe
705                 710                 715                 720 
Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe
                725                 730                 735     
Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser
            740                 745                 750         
Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn
        755                 760                 765             
Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg
    770                 775                 780                 
Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys
785                 790                 795                 800 
Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys
                805                 810                 815     
Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp
            820                 825                 830         
Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val
        835                 840                 845             
Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Val Arg Asn
    850                 855                 860                 
Ala Leu Asn Thr Val Leu Asn His Gln Leu Lys Leu Asn
865                 870                 875         

<210> 215
<211> 2542
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR020H08

<400> 215
atgaaggccc ccgctgtgct tgcacctggc atcctcgtgc tcctgtttac cttggtgcag 60
aggagcaatg gggagtgtaa agaggcacta gcaaagtccg agatgaatgt gaatatgaag 120
tatcagcttc ccaacttcac cgcggaaaca cccatccaga atgtcattct acatgagcat 180
cacattttcc ttggtgccac taactacatt tatgttttaa atgaggaaga ccttcagaag 240
gttgctgagt acaagactgg gcctgtgctg gaacacccag attgtttccc atgtcaggac 300
tgcagcagca aagccaattt atcaggaggt gtttggaaag ataacatcaa catggctcta 360
gttgtcgaca cctactatga tgatcaactc attagctgtg gcagcgtcaa cagagggacc 420
tgccagcgac atgtctttcc ccacaatcat actgctgaca tacagtcgga ggttcactgc 480
atattctccc cacagataga agagcccagc cagtgtcctg actgtgtggt gagcgccctg 540
ggagccaaag tcctttcatc tgtaaaggac cggttcatca acttctttgt aggcaatacc 600
ataaattctt cttatttccc agatcatcca ttgcattcga tatcagtgag aaggctaaag 660
gaaacgaaag atggttttat gtttttgacg gaccagtcct acattgatgc tttacctgag 720
ttcagagatt cttaccccat taagtatgtc catgcctttg aaagcaacaa ttttatttac 780
ttcttgacgg tccaaaggga aactctagat gctcagactt ttcacacaag aataatcagg 840
ttctgttcca taaactctgg attgcattcc tacatggaaa tgcctctgga gtgtattctc 900
acagaaaaga gaaaaaagag atccacaaag aaggaagtgt ttaatatact tcaggctgcg 960
tatgtcagca agcctggggc ccagcttgct agacaaatag gagccagcct gaatgatgac 1020
attcttttcg gggtgttcgc acaaagcaag ccagattctg ccgaaccaat ggatcgatct 1080
gccatgtgtg cattccctat caaatatgtc aacgacttct tcaacaagat cgtcaacaaa 1140
aacaatgtga gatgtctcca gcatttttac ggacccaatc atgagcactg ctttaatagg 1200
acacttctga gaaattcatc aggctgtgaa gcgcgccgtg atgaatatcg aacagagttt 1260
accacagctt tgcagcgcgt tgacttattc atgggtcaat tcagcgaagt cctcttaaca 1320
tctatatcca ccttcattaa aggagacctc accatagcta atcttgggac atcagagggt 1380
cgcttcatgc aggttgtggt ttctcgatca ggaccatcaa cccctcatgt gaattttctc 1440
ctggactccc atccagtgtc tccagaagtg attgtggagc atacattaaa ccaaaatggc 1500
tacacactgg ttatcactgg gaggaagatc acgaagatcc cattgaatgg cttgggctgc 1560
agacatttcc agtcctgcag tcaatgcctc tctgccccac cctttgttca gtgtggctgg 1620
tgccacgaca aatgtgtgcg atcggaggaa tgcctgagcg ggacatggac tcagcagatc 1680
tgtctgcctg caatctacaa ggttttccca aatagtgcac cccttgaagg agggacaagg 1740
ctgaccatat gtggctggga ctttggattt cggaggaata ataaatttga tttaaagaaa 1800
actagagttc tccttggaaa tgagagctgc accttgactt taagtgagag cacgatgaat 1860
acattgaaat gcacagttgg tcctgccatg aataagcatt tcaatatgtc cataattatt 1920
tcaaatggcc acgggacaac acaatacagt acattctcct atgtggatcc tgtaataaca 1980
agtatttcgc cgaaatacgg tcctatggct ggtggcactt tacttacttt aactggaaat 2040
tacctaaaca gtgggaattc tagacacatt tcaattggtg gaaaaacgtg tactttaaaa 2100
agtgtgtcaa acagtattct tgaatgttat accccagccc aaaccatttc aactgagtct 2160
gctgttaaat tgaaaattga cttagccaac cgagagacaa gcatcttcag ttaccgtgaa 2220
gatcccattg tctatgaaat tcatccaacc aaatctttta ttaggcatgt caacatcgct 2280
ctaattcaga gataatctgt tgtaccactc cttccctgca acagctgaat ctgcaactcc 2340
ccctgaaaac caaagccttt ttcatgttag atgggatcct ttccaaatac tttgatctca 2400
tttatgtaca taatcctgtg tctaagcctt ttggaaagcc agtgatgatc tcaatgggca 2460
atgaaaatgt actggaaatt aagataagaa atgctttaaa cactgtctta aatcatcagc 2520
tcaaacttaa ttgacttcat ag                                          2542

<210> 216
<211> 764
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR020H08

<400> 216
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Ala Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480 
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Arg Lys Ile Thr Lys
            500                 505                 510         
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525             
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540                 
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560 
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575     
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590         
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605             
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620                 
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640 
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
                645                 650                 655     
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly
            660                 665                 670         
Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg
        675                 680                 685             
His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn
    690                 695                 700                 
Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Ser
705                 710                 715                 720 
Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe
                725                 730                 735     
Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser
            740                 745                 750         
Phe Ile Arg His Val Asn Ile Ala Leu Ile Gln Arg
        755                 760                 

<210> 217
<211> 934
<212> PRT
<213> Homo sapiens

<220> 
<223> MET 34

<400> 217
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480 
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510         
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525             
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540                 
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560 
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575     
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590         
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605             
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620                 
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640 
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
                645                 650                 655     
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly
            660                 665                 670         
Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg
        675                 680                 685             
His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn
    690                 695                 700                 
Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe
705                 710                 715                 720 
Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe
                725                 730                 735     
Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser
            740                 745                 750         
Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn
        755                 760                 765             
Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg
    770                 775                 780                 
Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys
785                 790                 795                 800 
Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys
                805                 810                 815     
Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp
            820                 825                 830         
Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val
        835                 840                 845             
Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp
    850                 855                 860                 
Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys
865                 870                 875                 880 
Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val
                885                 890                 895     
Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Val Gly
            900                 905                 910         
Phe Leu His Ser Ser His Asp Val Asn Lys Glu Ala Ser Val Ile Met
        915                 920                 925             
Leu Phe Ser Gly Leu Lys
    930                 

<210> 218
<211> 1589
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (29)...(1516)
<223> SR004C11

<400> 218
ggatcctcta gggtcccagc tcgcctcg atg gag ctc ctc ccg ccg ctg cct    52
                               Met Glu Leu Leu Pro Pro Leu Pro
                                1               5
 
cag tcc ttc ctg ttg ctg ctg ctg ttg cct gcc aag ccc gcg gcg ggc   100
Gln Ser Phe Leu Leu Leu Leu Leu Leu Pro Ala Lys Pro Ala Ala Gly
     10                  15                  20
 
gag gac tgg cag tgc ccg cgc acc ccc tac gcg gcc tct cgc gac ttt   148
Glu Asp Trp Gln Cys Pro Arg Thr Pro Tyr Ala Ala Ser Arg Asp Phe
 25                  30                  35                  40
 
gac gtg aag tac gtg gtg ccc agc ttc tcc gcc gga ggc ctg gta cag   196
Asp Val Lys Tyr Val Val Pro Ser Phe Ser Ala Gly Gly Leu Val Gln
                 45                  50                  55
 
gcc atg gtg acc tac gag ggc gac aga aat gag agt gct gtg ttt gta   244
Ala Met Val Thr Tyr Glu Gly Asp Arg Asn Glu Ser Ala Val Phe Val
             60                  65                  70
 
gcc ata cgc aat cgc ctg cat gtg ctt ggg cct gac ctg aag tct gtc   292
Ala Ile Arg Asn Arg Leu His Val Leu Gly Pro Asp Leu Lys Ser Val
         75                  80                  85
 
cag agc ctg gcc acg ggc cct gct gga gac cct ggc tgc cag acg tgt   340
Gln Ser Leu Ala Thr Gly Pro Ala Gly Asp Pro Gly Cys Gln Thr Cys
     90                  95                 100
 
gca gcc tgt ggc cca gga ccc cac ggc cct ccc ggt gac aca gac aca   388
Ala Ala Cys Gly Pro Gly Pro His Gly Pro Pro Gly Asp Thr Asp Thr
105                 110                 115                 120
 
aag gtg ctg gtg ctg gat ccc gcg ctg cct gcg ctg gtc agt tgt ggc   436
Lys Val Leu Val Leu Asp Pro Ala Leu Pro Ala Leu Val Ser Cys Gly
                125                 130                 135
 
tcc agc ctg cag ggc cgc tgc ttc ctg cat gac cta gag ccc caa ggg   484
Ser Ser Leu Gln Gly Arg Cys Phe Leu His Asp Leu Glu Pro Gln Gly
            140                 145                 150
 
aca gcc gtg cat ctg gca gcg cca gcc tgc ctc ttc tca gcc cac cat   532
Thr Ala Val His Leu Ala Ala Pro Ala Cys Leu Phe Ser Ala His His
        155                 160                 165
 
aac cgg ccc gat gac tgc ccc gac tgt gtg gcc agc cca ttg ggc acc   580
Asn Arg Pro Asp Asp Cys Pro Asp Cys Val Ala Ser Pro Leu Gly Thr
    170                 175                 180
 
cgt gta act gtg gtt gag caa ggc cag gcc tcc tat ttc tac gtg gca   628
Arg Val Thr Val Val Glu Gln Gly Gln Ala Ser Tyr Phe Tyr Val Ala
185                 190                 195                 200
 
tcc tca ctg gac gca gcc gtg gct gcc agc ttc agc cca cgc tca gtg   676
Ser Ser Leu Asp Ala Ala Val Ala Ala Ser Phe Ser Pro Arg Ser Val
                205                 210                 215
 
tct atc agg cgt ctc aag gct gac gcc tcg gga ttc gca ccg ggc ttt   724
Ser Ile Arg Arg Leu Lys Ala Asp Ala Ser Gly Phe Ala Pro Gly Phe
            220                 225                 230
 
gtg gcg ttg tca gtg ctg ccc aag cat ctt gtc tcc tac agt att gaa   772
Val Ala Leu Ser Val Leu Pro Lys His Leu Val Ser Tyr Ser Ile Glu
        235                 240                 245
 
tac gtg cac agc ttc cac acg gga gcc ttc gta tac ttc ctg act gta   820
Tyr Val His Ser Phe His Thr Gly Ala Phe Val Tyr Phe Leu Thr Val
    250                 255                 260
 
cag ccg gcc agc gtg aca gat gat cct agt gcc ctg cac aca cgc ctg   868
Gln Pro Ala Ser Val Thr Asp Asp Pro Ser Ala Leu His Thr Arg Leu
265                 270                 275                 280
 
gca cgg ctt agc gcc act gag cca gag ttg ggt gac tat cgg gag ctg   916
Ala Arg Leu Ser Ala Thr Glu Pro Glu Leu Gly Asp Tyr Arg Glu Leu
                285                 290                 295
 
gtc ctc gac tgc aga ttt gct cca aaa cgc agg cgc cgg ggg gcc cca   964
Val Leu Asp Cys Arg Phe Ala Pro Lys Arg Arg Arg Arg Gly Ala Pro
            300                 305                 310
 
gaa ggc gga cag ccc tac cct gtg ctg cgg gtg gcc cac tcc gct cca   1012
Glu Gly Gly Gln Pro Tyr Pro Val Leu Arg Val Ala His Ser Ala Pro
        315                 320                 325
 
gtg ggt gcc caa ctt gcc act gag ctg agc atc gcc gag ggc cag gaa   1060
Val Gly Ala Gln Leu Ala Thr Glu Leu Ser Ile Ala Glu Gly Gln Glu
    330                 335                 340
 
gta cta ttt ggg gtc ttt gtg act ggc aag gat ggt ggt cct ggc gtg   1108
Val Leu Phe Gly Val Phe Val Thr Gly Lys Asp Gly Gly Pro Gly Val
345                 350                 355                 360
 
ggc ccc aac tct gtc gtc tgt gcc ttc ccc att gac ctg ctg gac aca   1156
Gly Pro Asn Ser Val Val Cys Ala Phe Pro Ile Asp Leu Leu Asp Thr
                365                 370                 375
 
cta att gat gag ggt gtg gag cgc tgt tgt gaa tcc cca gtc cat cca   1204
Leu Ile Asp Glu Gly Val Glu Arg Cys Cys Glu Ser Pro Val His Pro
            380                 385                 390
 
ggc ctc cgg cga ggc ctc gac ttc ttc cag tcg ccc agt ttt tgc ccc   1252
Gly Leu Arg Arg Gly Leu Asp Phe Phe Gln Ser Pro Ser Phe Cys Pro
        395                 400                 405
 
aac ccg cct ggc ctg gaa gcc ctc agc ccc aac acc agc tgc cgc cac   1300
Asn Pro Pro Gly Leu Glu Ala Leu Ser Pro Asn Thr Ser Cys Arg His
    410                 415                 420
 
ttc cct ctg ctg gtc agt agc agc ttc tca cgt gtg gac cta ttc aat   1348
Phe Pro Leu Leu Val Ser Ser Ser Phe Ser Arg Val Asp Leu Phe Asn
425                 430                 435                 440
 
ggg ctg ttg gga cca gta cag gtc act gca ttg tat gtg aca cgc ctt   1396
Gly Leu Leu Gly Pro Val Gln Val Thr Ala Leu Tyr Val Thr Arg Leu
                445                 450                 455
 
gac aac gtc aca gtg gca cac atg ggc aca atg gat ggg cgt atc ctg   1444
Asp Asn Val Thr Val Ala His Met Gly Thr Met Asp Gly Arg Ile Leu
            460                 465                 470
 
cag gtg ggt cct cat ccc cac agt ccc cta gcc ctg ggt cct tgt ctc   1492
Gln Val Gly Pro His Pro His Ser Pro Leu Ala Leu Gly Pro Cys Leu
        475                 480                 485
 
cat ccc cat ttt gct cac atc tga cctgtcctag gtggagctgg tcaggtcact  1546
His Pro His Phe Ala His Ile  *
    490                 495
 
aaactacttg ctgtatgtgt ccaacttctc actgggtgac agt                   1589

<210> 219
<211> 495
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR004C11

<400> 219
Met Glu Leu Leu Pro Pro Leu Pro Gln Ser Phe Leu Leu Leu Leu Leu
 1               5                  10                  15      
Leu Pro Ala Lys Pro Ala Ala Gly Glu Asp Trp Gln Cys Pro Arg Thr
            20                  25                  30          
Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val Lys Tyr Val Val Pro Ser
        35                  40                  45              
Phe Ser Ala Gly Gly Leu Val Gln Ala Met Val Thr Tyr Glu Gly Asp
    50                  55                  60                  
Arg Asn Glu Ser Ala Val Phe Val Ala Ile Arg Asn Arg Leu His Val
65                  70                  75                  80  
Leu Gly Pro Asp Leu Lys Ser Val Gln Ser Leu Ala Thr Gly Pro Ala
                85                  90                  95      
Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala Cys Gly Pro Gly Pro His
            100                 105                 110         
Gly Pro Pro Gly Asp Thr Asp Thr Lys Val Leu Val Leu Asp Pro Ala
        115                 120                 125             
Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe
    130                 135                 140                 
Leu His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro
145                 150                 155                 160 
Ala Cys Leu Phe Ser Ala His His Asn Arg Pro Asp Asp Cys Pro Asp
                165                 170                 175     
Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln Gly
            180                 185                 190         
Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Ala Ala Val Ala
        195                 200                 205             
Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ala Asp
    210                 215                 220                 
Ala Ser Gly Phe Ala Pro Gly Phe Val Ala Leu Ser Val Leu Pro Lys
225                 230                 235                 240 
His Leu Val Ser Tyr Ser Ile Glu Tyr Val His Ser Phe His Thr Gly
                245                 250                 255     
Ala Phe Val Tyr Phe Leu Thr Val Gln Pro Ala Ser Val Thr Asp Asp
            260                 265                 270         
Pro Ser Ala Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro
        275                 280                 285             
Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys Arg Phe Ala Pro
    290                 295                 300                 
Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Gly Gln Pro Tyr Pro Val
305                 310                 315                 320 
Leu Arg Val Ala His Ser Ala Pro Val Gly Ala Gln Leu Ala Thr Glu
                325                 330                 335     
Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val Thr
            340                 345                 350         
Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn Ser Val Val Cys Ala
        355                 360                 365             
Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp Glu Gly Val Glu Arg
    370                 375                 380                 
Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg Arg Gly Leu Asp Phe
385                 390                 395                 400 
Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Pro Gly Leu Glu Ala Leu
                405                 410                 415     
Ser Pro Asn Thr Ser Cys Arg His Phe Pro Leu Leu Val Ser Ser Ser
            420                 425                 430         
Phe Ser Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Pro Val Gln Val
        435                 440                 445             
Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn Val Thr Val Ala His Met
    450                 455                 460                 
Gly Thr Met Asp Gly Arg Ile Leu Gln Val Gly Pro His Pro His Ser
465                 470                 475                 480 
Pro Leu Ala Leu Gly Pro Cys Leu His Pro His Phe Ala His Ile
                485                 490                 495 

<210> 220
<211> 3113
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR014C01

<400> 220
ggtcccagct cgcctcgatg gagctcctcc cgccgctgcc tcagtccttc ctgttgctgc 60
tgctgttgcc tgccaagccc gcggcgggcg aggactggca gtgcccgcgc accccctacg 120
cggcctctcg cgactttgac gtgaagtacg tggtgcccag cttctccgcc ggaggcctgg 180
tacaggccat ggtgacctac gagggcgaca gaaatgagag tgctgtgttt gtagccatac 240
gcaatcgcct gcatgtgctt gggcctgacc tgaagtctgt ccagagcctg gccacgggcc 300
ctgctggaga ccctggctgc cagacgtgtg cagcctgtgg cccaggaccc cacggccctc 360
ccggtgacac agacacaaag gtgctggtgc tggatcccgc gctgcctgcg ctggtcagtt 420
gtggctccag cctgcagggc cgctgcttcc tgcatgacct agagccccaa gggacagccg 480
tgcatctggc agcgccagcc tgcctcttct cagcccacca taaccggccc gatgactgcc 540
ccgactgtgt ggccagccca ttgggcaccc gtgtaactgt ggttgagcaa ggccaggcct 600
cctatttcta cgtggcatcc tcactggacg cagccgtggc tgccagcttc agcccacgct 660
cagtgtctat caggcgtctc aaggctgacg cctcgggatt cgcaccgggc tttgtggcgt 720
tgtcagtgct gcccaagcat cttgtctcct acagtattga atacgtgcac agcttccaca 780
cgggagcctt cgtatacttc ctgactgtac agccggccag cgtgacagat gatcctagtg 840
ccctgcacac acgcctggca cggcttagcg ccactgagcc agagttgggt gactatcggg 900
agctggtcct cgactgcaga tttgctccaa aacgcaggcg ccggggggcc ccagaaggcg 960
gacagcccta ccctgtgctg cgggtggccc actccgctcc agtgggtgcc caacttgcca 1020
ctgagctgag catcgccgag ggccaggaag tactatttgg ggtctttgtg actggcaagg 1080
atggtggtcc tggcgtgggc cccaactctg tcgtctgtgc cttccccatt gacctgctgg 1140
acacactaat tgatgagggt gtggagcgct gttgtgaatc cccagtccat ccaggcctcc 1200
ggcgaggcct cgacttcttc cagtcgccca gtttttgccc caacccggtt ttccaggtac 1260
ctatccaagg ccctggctgc cgccacttcc tgacctgtgg gcgttgccta agggcatggc 1320
atttcatggg ctgtggctgg tgtgggaaca tgtgcggcca gcagaaggag tgtcctggct 1380
cctggcaaca ggaccactgc ccacctaagc ttactgagtt ccacccccac agtggacctc 1440
taaggggcag tacaaggctg accctgtgtg gctccaactt ctaccttcac ccttctggtc 1500
tggtgcctga gggaacccat caggtcactg tgggccaaag tccctgccgg ccactgccca 1560
aggacagctc aaaactcagg tacaatctgg tccctcccct ccctttccct gaagggggaa 1620
accaagcagc cccttcccca tgagaccctg ttctctgctt atcagaggca aggggggatg 1680
ggggaagctg cagtggttct gactgctttt tgagagtcaa aaaggtctct gtcccttttt 1740
gagctttcat gtgcccttcc tgtctgttca ctcatggacc agccaaggtt aatctctgcc 1800
ccaccagaac cttccttcca tggagggagg catgggtgga gaaatgccat tctctggctc 1860
agaggagccc tgtggcttgt ggcaggcatg catctaggcc tgtgtaattc ctggctgacc 1920
tcaggggttc ccctggtgcc ccagaccagt gccccggaaa gactttgtag aggagtttga 1980
gtgtgaactg gagcccttgg gcacccaggc agtggggcct accaacgtca gcctcaccgt 2040
gactaacatg ccaccgggca agcacttccg ggtagacggc acctccgtgc tgagaggctt 2100
ctctttcatg gagccagtgc tgatagcagt gcaacccctc tttggcccac gggcaggagg 2160
cacctgtctc actcttgaag gccagagtct gtctgtaggc accagccggg ctgtgctggt 2220
caatgggact gagtgtctgc tagcacgggt cagtgagggg cagcttttat gtgccacacc 2280
ccctggggcc acggtggcca gtgtccccct tagcctgcag gtggggggtg cccaggtacc 2340
tggttcctgg accttccagt acagagaaga ccctgtcgtg ctaagcatca gccccaactg 2400
tggctacatc aactcccaca tcaccatctg tggccagcat ctaacttcag catggcactt 2460
agtgctgtca ttccatgacg ggcttagggc agtggaaagc aggtgtgaga ggcagcttcc 2520
agagcagcag ctgtgccgcc ttcctgaata tgtggtccga gacccccagg gatgggtggc 2580
agggaatctg agtgcccgag gggatggagc tgctggcttt acactgcctg gctttcgctt 2640
cctaccccca ccccatccac ccagtgccaa cctagttcca ctgaagcctg aggagcatgc 2700
cattaagttt gaggtaagtg taagggatag gggcagggac agttggggat ctgaaagtag 2760
gggccagcct actggctggt cctcatgacc ctctctgcag tatattgggc tgggcgctgt 2820
ggctgactgt gtgggtatca acgtgaccgt gggtggtgag agctgccagc acgagttccg 2880
gggggacatg gttgtctgcc ccctgccccc atccctgcag cttggccagg atggtgcccc 2940
attgcaggtc tgcgtagatg gtgaatgtca tatcctgggt agagtggtgc ggccagggcc 3000
agatggggtc ccacagagca cgctccttgg tatcctgctg cctttgctgc tgcttgtggc 3060
tgcactggcg actgcactgg tcttcagcta ctggtggcgg aggaagcagc tag        3113

<210> 221
<211> 541
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR014C01

<400> 221
Met Glu Leu Leu Pro Pro Leu Pro Gln Ser Phe Leu Leu Leu Leu Leu
 1               5                  10                  15      
Leu Pro Ala Lys Pro Ala Ala Gly Glu Asp Trp Gln Cys Pro Arg Thr
            20                  25                  30          
Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val Lys Tyr Val Val Pro Ser
        35                  40                  45              
Phe Ser Ala Gly Gly Leu Val Gln Ala Met Val Thr Tyr Glu Gly Asp
    50                  55                  60                  
Arg Asn Glu Ser Ala Val Phe Val Ala Ile Arg Asn Arg Leu His Val
65                  70                  75                  80  
Leu Gly Pro Asp Leu Lys Ser Val Gln Ser Leu Ala Thr Gly Pro Ala
                85                  90                  95      
Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala Cys Gly Pro Gly Pro His
            100                 105                 110         
Gly Pro Pro Gly Asp Thr Asp Thr Lys Val Leu Val Leu Asp Pro Ala
        115                 120                 125             
Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe
    130                 135                 140                 
Leu His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro
145                 150                 155                 160 
Ala Cys Leu Phe Ser Ala His His Asn Arg Pro Asp Asp Cys Pro Asp
                165                 170                 175     
Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln Gly
            180                 185                 190         
Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Ala Ala Val Ala
        195                 200                 205             
Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ala Asp
    210                 215                 220                 
Ala Ser Gly Phe Ala Pro Gly Phe Val Ala Leu Ser Val Leu Pro Lys
225                 230                 235                 240 
His Leu Val Ser Tyr Ser Ile Glu Tyr Val His Ser Phe His Thr Gly
                245                 250                 255     
Ala Phe Val Tyr Phe Leu Thr Val Gln Pro Ala Ser Val Thr Asp Asp
            260                 265                 270         
Pro Ser Ala Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro
        275                 280                 285             
Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys Arg Phe Ala Pro
    290                 295                 300                 
Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Gly Gln Pro Tyr Pro Val
305                 310                 315                 320 
Leu Arg Val Ala His Ser Ala Pro Val Gly Ala Gln Leu Ala Thr Glu
                325                 330                 335     
Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val Thr
            340                 345                 350         
Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn Ser Val Val Cys Ala
        355                 360                 365             
Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp Glu Gly Val Glu Arg
    370                 375                 380                 
Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg Arg Gly Leu Asp Phe
385                 390                 395                 400 
Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Val Phe Gln Val Pro Ile
                405                 410                 415     
Gln Gly Pro Gly Cys Arg His Phe Leu Thr Cys Gly Arg Cys Leu Arg
            420                 425                 430         
Ala Trp His Phe Met Gly Cys Gly Trp Cys Gly Asn Met Cys Gly Gln
        435                 440                 445             
Gln Lys Glu Cys Pro Gly Ser Trp Gln Gln Asp His Cys Pro Pro Lys
    450                 455                 460                 
Leu Thr Glu Phe His Pro His Ser Gly Pro Leu Arg Gly Ser Thr Arg
465                 470                 475                 480 
Leu Thr Leu Cys Gly Ser Asn Phe Tyr Leu His Pro Ser Gly Leu Val
                485                 490                 495     
Pro Glu Gly Thr His Gln Val Thr Val Gly Gln Ser Pro Cys Arg Pro
            500                 505                 510         
Leu Pro Lys Asp Ser Ser Lys Leu Arg Tyr Asn Leu Val Pro Pro Leu
        515                 520                 525             
Pro Phe Pro Glu Gly Gly Asn Gln Ala Ala Pro Ser Pro
    530                 535                 540     

<210> 222
<211> 3069
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR014C09

<400> 222
ggtcccagct cgcctcgatg gagctcctcc cgccgctgcc tcagtccttc ctgttgctgc 60
tgctgttgcc tgccaagccc gcggcgggcg aggactggca gtgcccgcgc accccctacg 120
cggcctctcg cgactttgac gtgaagtacg tggtgcccag cttctccgcc ggaggcctgg 180
tacaggccat ggtgacctac gagggcgaca gaaatgagag tgctgtgttt gtagccatac 240
gcaatcgcct gcatgtgctt gggcctgacc tgaagtctgt ccagagcctg gccacgggcc 300
ctgctggaga ccctggctgc cagacgtgtg cagcctgtgg cccaggaccc cacggccctc 360
ccggtgacac agacacaaag gtgctggtgc tggatcccgc gctgcctgcg ctggtcagtt 420
gtggctccag cctgcagggc cgctgcttcc tgcatgacct agagccccaa gggacagccg 480
tgcatctggc agcgccagcc tgcctcttct cagcccacca taaccggccc gatgactgcc 540
ccgactgtgt ggccagccca ttgggcaccc gtgtaactgt ggttgagcaa ggccaggcct 600
cctatttcta cgtggcatcc tcactggacg cagccgtggc tgccagcttc agcccacgct 660
cagtgtctat caggcgtctc aaggctgacg cctcgggatt cgcaccgggc tttgtggcgt 720
tgtcagtgct gcccaagcat cttgtctcct acagtattga atacgtgcac agcttccaca 780
cgggagcctt cgtatacttc ctgactgtac agccggccag cgtgacagat gatcctagtg 840
ccctgcacac acgcctggca cggcttagcg ccactgagcc agagttgggt gactatcggg 900
agctggtcct cgactgcaga tttgctccaa aacgcaggcg ccggggggcc ccagaaggcg 960
gacagcccta ccctgtgctg cgggtggccc actccgctcc agtgggtgcc caacttgcca 1020
ctgagctgag catcgccgag ggccaggaag tactatttgg ggtctttgtg actggcaagg 1080
atggtggtcc tggcgtgggc cccaactctg tcgtctgtgc cttccccatt gacctgctgg 1140
acacactaat tgatgagggt gtggagcgct gttgtgaatc cccagtccat ccaggcctcc 1200
ggcgaggcct cgacttcttc cagtcgccca gtttttgccc caacccgcct ggcctggaag 1260
ccctcagccc caacaccagc tgccgccact tccctctgct ggtcagtagc agcttctcac 1320
gtgtggacct attcaatggg ctgttgggac cagtacaggt cactgcattg tatgtgacac 1380
gccttgacaa cgtcacagtg gcacacatgg gcacaatgga tgggcgtatc ctgcaggtgg 1440
agctggtcag gtcactaaac tacttgctgt atgtgtccaa cttctcactg ggtgacagtg 1500
ggcagcccgt gcagcgggat gtcagtcgtc ttggggacca cctactcttt gcctctgggg 1560
accaggtttt ccaggtacct atccaaggcc ctggctgccg ccacttcctg acctgtgggc 1620
gttgcctaag ggcatggcat ttcatgggct gtggctggtg tgggaacatg tgcggccagc 1680
agaaggagtg tcctggctcc tggcaacagg accactgccc acctaagctt actgagttcc 1740
acccccacag tggacctcta aggggcagta caaggctgac cctgtgtggc tccaacttct 1800
accttcaccc ttctggtctg gtgcctgagg gaacccatca ggtcactgtg ggccaaagtc 1860
cctgccggcc actgcccaag gacagctcaa aactcagacc agtgccccgg aaagactttg 1920
tagaggagtt tgagtgtgaa ctggagccct tgggcaccca ggcagtgggg cctaccaacg 1980
tcagcctcac cgtgactaac atgccaccgg gcaagcactt ccgggtagac ggcacctccg 2040
tgctgagagg cttctctttc atggagccag tgctgatagc agtgcaaccc ctctttggcc 2100
cacgggcagg aggcacctgt ctcactcttg aaggccagag tctgtctgta ggcaccagcc 2160
gggctgtgct ggtcaatggg actgagtgtc tgctagcacg ggtcagtgag gggcagcttt 2220
tatgtgccac accccctggg gccacggtgg ccagtgtccc ccttagcctg caggtggggg 2280
gtgcccaggt acctggttcc tggaccttcc agtacagaga agaccctgtc gtgctaagca 2340
tcagccccaa ctgtggctac atcaactccc acatcaccat ctgtggccag catctaactt 2400
cagcatggca cttagtgctg tcattccatg acgggcttag ggcagtggaa agcaggcagt 2460
gtgagaggca gcttccagag cagcagctgt gccgccttcc tgaatatgtg gtccgagacc 2520
cccagggatg ggtggcaggg aatctgagtg cccgagggga tggagctgct ggctttacac 2580
tgcctggctt tcgcttccta cccccacccc atccacccag tgccaaccta gttccactga 2640
agcctgagga gcatgccatt aagtttgagg taagtgtaag ggataggggc agggacagtt 2700
ggggatctga aagtaggggc cagcctactg gctggtcctc atgaccctct ctgcagtata 2760
ttgggctggg cgctgtggct gactgtgtgg gtatcaacgt gaccgtgggt ggtgagagct 2820
gccagcacga gttccggggg gacatggttg tctgccccct gcccccatcc ctgcagcttg 2880
gccaggatgg tgccccattg caggtctgcg tagatggtga atgtcatatc ctgggtagag 2940
tggtgcggcc agggccagat ggggtcccac agagcacgct ccttggtatc ctgctgcctt 3000
tgctgctgct tgtggctgca ctggcgactg cactggtctt cagctactgg tggcggagga 3060
agcagctag                                                         3069

<210> 223
<211> 908
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR014C09

<400> 223
Met Glu Leu Leu Pro Pro Leu Pro Gln Ser Phe Leu Leu Leu Leu Leu
 1               5                  10                  15      
Leu Pro Ala Lys Pro Ala Ala Gly Glu Asp Trp Gln Cys Pro Arg Thr
            20                  25                  30          
Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val Lys Tyr Val Val Pro Ser
        35                  40                  45              
Phe Ser Ala Gly Gly Leu Val Gln Ala Met Val Thr Tyr Glu Gly Asp
    50                  55                  60                  
Arg Asn Glu Ser Ala Val Phe Val Ala Ile Arg Asn Arg Leu His Val
65                  70                  75                  80  
Leu Gly Pro Asp Leu Lys Ser Val Gln Ser Leu Ala Thr Gly Pro Ala
                85                  90                  95      
Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala Cys Gly Pro Gly Pro His
            100                 105                 110         
Gly Pro Pro Gly Asp Thr Asp Thr Lys Val Leu Val Leu Asp Pro Ala
        115                 120                 125             
Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe
    130                 135                 140                 
Leu His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro
145                 150                 155                 160 
Ala Cys Leu Phe Ser Ala His His Asn Arg Pro Asp Asp Cys Pro Asp
                165                 170                 175     
Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln Gly
            180                 185                 190         
Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Ala Ala Val Ala
        195                 200                 205             
Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ala Asp
    210                 215                 220                 
Ala Ser Gly Phe Ala Pro Gly Phe Val Ala Leu Ser Val Leu Pro Lys
225                 230                 235                 240 
His Leu Val Ser Tyr Ser Ile Glu Tyr Val His Ser Phe His Thr Gly
                245                 250                 255     
Ala Phe Val Tyr Phe Leu Thr Val Gln Pro Ala Ser Val Thr Asp Asp
            260                 265                 270         
Pro Ser Ala Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro
        275                 280                 285             
Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys Arg Phe Ala Pro
    290                 295                 300                 
Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Gly Gln Pro Tyr Pro Val
305                 310                 315                 320 
Leu Arg Val Ala His Ser Ala Pro Val Gly Ala Gln Leu Ala Thr Glu
                325                 330                 335     
Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val Thr
            340                 345                 350         
Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn Ser Val Val Cys Ala
        355                 360                 365             
Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp Glu Gly Val Glu Arg
    370                 375                 380                 
Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg Arg Gly Leu Asp Phe
385                 390                 395                 400 
Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Pro Gly Leu Glu Ala Leu
                405                 410                 415     
Ser Pro Asn Thr Ser Cys Arg His Phe Pro Leu Leu Val Ser Ser Ser
            420                 425                 430         
Phe Ser Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Pro Val Gln Val
        435                 440                 445             
Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn Val Thr Val Ala His Met
    450                 455                 460                 
Gly Thr Met Asp Gly Arg Ile Leu Gln Val Glu Leu Val Arg Ser Leu
465                 470                 475                 480 
Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Asp Ser Gly Gln
                485                 490                 495     
Pro Val Gln Arg Asp Val Ser Arg Leu Gly Asp His Leu Leu Phe Ala
            500                 505                 510         
Ser Gly Asp Gln Val Phe Gln Val Pro Ile Gln Gly Pro Gly Cys Arg
        515                 520                 525             
His Phe Leu Thr Cys Gly Arg Cys Leu Arg Ala Trp His Phe Met Gly
    530                 535                 540                 
Cys Gly Trp Cys Gly Asn Met Cys Gly Gln Gln Lys Glu Cys Pro Gly
545                 550                 555                 560 
Ser Trp Gln Gln Asp His Cys Pro Pro Lys Leu Thr Glu Phe His Pro
                565                 570                 575     
His Ser Gly Pro Leu Arg Gly Ser Thr Arg Leu Thr Leu Cys Gly Ser
            580                 585                 590         
Asn Phe Tyr Leu His Pro Ser Gly Leu Val Pro Glu Gly Thr His Gln
        595                 600                 605             
Val Thr Val Gly Gln Ser Pro Cys Arg Pro Leu Pro Lys Asp Ser Ser
    610                 615                 620                 
Lys Leu Arg Pro Val Pro Arg Lys Asp Phe Val Glu Glu Phe Glu Cys
625                 630                 635                 640 
Glu Leu Glu Pro Leu Gly Thr Gln Ala Val Gly Pro Thr Asn Val Ser
                645                 650                 655     
Leu Thr Val Thr Asn Met Pro Pro Gly Lys His Phe Arg Val Asp Gly
            660                 665                 670         
Thr Ser Val Leu Arg Gly Phe Ser Phe Met Glu Pro Val Leu Ile Ala
        675                 680                 685             
Val Gln Pro Leu Phe Gly Pro Arg Ala Gly Gly Thr Cys Leu Thr Leu
    690                 695                 700                 
Glu Gly Gln Ser Leu Ser Val Gly Thr Ser Arg Ala Val Leu Val Asn
705                 710                 715                 720 
Gly Thr Glu Cys Leu Leu Ala Arg Val Ser Glu Gly Gln Leu Leu Cys
                725                 730                 735     
Ala Thr Pro Pro Gly Ala Thr Val Ala Ser Val Pro Leu Ser Leu Gln
            740                 745                 750         
Val Gly Gly Ala Gln Val Pro Gly Ser Trp Thr Phe Gln Tyr Arg Glu
        755                 760                 765             
Asp Pro Val Val Leu Ser Ile Ser Pro Asn Cys Gly Tyr Ile Asn Ser
    770                 775                 780                 
His Ile Thr Ile Cys Gly Gln His Leu Thr Ser Ala Trp His Leu Val
785                 790                 795                 800 
Leu Ser Phe His Asp Gly Leu Arg Ala Val Glu Ser Arg Gln Cys Glu
                805                 810                 815     
Arg Gln Leu Pro Glu Gln Gln Leu Cys Arg Leu Pro Glu Tyr Val Val
            820                 825                 830         
Arg Asp Pro Gln Gly Trp Val Ala Gly Asn Leu Ser Ala Arg Gly Asp
        835                 840                 845             
Gly Ala Ala Gly Phe Thr Leu Pro Gly Phe Arg Phe Leu Pro Pro Pro
    850                 855                 860                 
His Pro Pro Ser Ala Asn Leu Val Pro Leu Lys Pro Glu Glu His Ala
865                 870                 875                 880 
Ile Lys Phe Glu Val Ser Val Arg Asp Arg Gly Arg Asp Ser Trp Gly
                885                 890                 895     
Ser Glu Ser Arg Gly Gln Pro Thr Gly Trp Ser Ser
            900                 905             

<210> 224
<211> 3500
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR014E12

<400> 224
ggtcccagct cgcctcgatg gagctcctcc cgccgctgcc tcagtccttc ctgttgctgc 60
tgctgttgcc tgccaagccc gcggcgggcg aggactggca gtgcccgcgc accccctacg 120
cggcctctcg cgactttgac gtgaagtacg tggtgcccag cttctccgcc ggaggcctgg 180
tacaggccat ggtgacctac gagggcgaca gaaatgagag tgctgtgttt gtagccatac 240
gcaatcgcct gcatgtgctt gggcctgacc tgaagtctgt ccagagcctg gccacgggcc 300
ctgctggaga ccctggctgc cagacgtgtg cagcctgtgg cccaggaccc cacggccctc 360
ccggtgacac agacacaaag gtgctggtgc tggatcccgc gctgcctgcg ctggtcagtt 420
gtggctccag cctgcagggc cgctgcttcc tgcatgacct agagccccaa gggacagccg 480
tgcatctggc agcgccagcc tgcctcttct cagcccacca taaccggccc gatgactgcc 540
ccgactgtgt ggccagccca ttgggcaccc gtgtaactgt ggttgagcaa ggccaggcct 600
cctatttcta cgtggcatcc tcactggacg cagccgtggc tgccagcttc agcccacgct 660
cagtgtctat caggcgtctc aaggctgacg cctcgggatt cgcaccgggc tttgtggcgt 720
tgtcagtgct gcccaagcat cttgtctcct acagtattga atacgtgcac agcttccaca 780
cgggagcctt cgtatacttc ctgactgtac agccggccag cgtgacagat gatcctagtg 840
ccctgcacac acgcctggca cggcttagcg ccactgagcc agagttgggt gactatcggg 900
agctggtcct cgactgcaga tttgctccaa aacgcaggcg ccggggggcc ccagaaggcg 960
gacagcccta ccctgtgctg cgggtggccc actccgctcc agtgggtgcc caacttgcca 1020
ctgagctgag catcgccgag ggccaggaag tactatttgg ggtctttgtg actggcaagg 1080
atggtggtcc tggcgtgggc cccaactctg tcgtctgtgc cttccccatt gacctgctgg 1140
acacactaat tgatgagggt gtggagcgct gttgtgaatc cccagtccat ccaggcctcc 1200
ggcgaggcct cgacttcttc cagtcgccca gtttttgccc caacccgcct ggcctggaag 1260
ccctcagccc caacaccagc tgccgccact tccctctgct ggtcagtagc agcttctcac 1320
gtgtggacct attcaatggg ctgttgggac cagtacaggt cactgcattg tatgtgacac 1380
gccttgacaa cgtcacagtg gcacacatgg gcacaatgga tgggcgtatc ctgcaggtgg 1440
agctggtcag gtcactaaac tacttgctgt atgtgtccaa cttctcactg ggtgacagtg 1500
ggcagcccgt gcagcgggat gtcagtcgtc ttggggacca cctactcttt gcctctgggg 1560
accaggtttt ccaggtacct atccaaggcc ctggctgccg ccacttcctg acctgtgggc 1620
gttgcctaag ggcatggcat ttcatgggct gtggctggtg tgggaacatg tgcggccagc 1680
agaaggagtg tcctggctcc tggcaacagg accactgccc acctaagctt actgagttcc 1740
acccccacag tggacctcta aggggcagta caaggctgac cctgtgtggc tccaacttct 1800
accttcaccc ttctggtctg gtgcctgagg gaacccatca ggtcactgtg ggccaaagtc 1860
cctgccggcc actgcccaag gacagctcaa aactcaggta caatctggtc cctcccctcc 1920
ctttccctga agggggaaac caagcagccc cttccccatg agaccctgtt ctctgcttat 1980
cagaggcaag gggggatggg ggaagctgca gtggttctga ctgctttttg agagtcaaaa 2040
aggtctctgt ccctttttga gctttcatgt gcccttcctg tctgttcact catggaccag 2100
ccaaggttaa tctctgcccc accagaacct tccttccatg gagggaggca tgggtggaga 2160
aatgccattc tctggctcag aggagccctg tggcttgtgg caggcatgca tctaggcctg 2220
tgtaattcct ggctgacctc aggggttccc ctggtgcccc agaccagtgc cccggaaaga 2280
ctttgtagag gagtttgagt gtgaactgga gcccttgggc acccaggcag tggggcctac 2340
caacgtcagc ctcaccgtga ctaacatgcc accgggcaag cacttccggg tagacggcac 2400
ctccgtgctg agaggcttct ctttcatgga gccagtgctg atagcagtgc aacccctctt 2460
tggcccacgg gcaggaggca cctgtctcac tcttgaaggc cagagtctgt ctgtaggcac 2520
cagccgggct gtgctggtca atgggactga gtgtctgcta gcacgggtca gtgaggggca 2580
gcttttatgt gccacacccc ctggggccac ggtggccagt gtccccctta gcctgcaggt 2640
ggggggtgcc caggtacctg gttcctggac cttccagtac agagaagacc ctgtcgtgct 2700
aagcatcagc cccaactgtg gctacatcaa ctcccacatc accatctgtg gccagcatct 2760
aacttcagca tggcacttag tgctgtcatt ccatgacggg cttagggcag tggaaagcag 2820
gtgtgagagg cagcttccag agcagcagct gtgccgcctt cctgaatatg tggtccgaga 2880
cccccaggga tgggtggcag ggaatctgag tgcccgaggg gatggagctg ctggctttac 2940
actgcctggc tttcgcttcc tacccccacc ccatccaccc agtgccaacc tagttccact 3000
gaagcctgag gagcatgcca ttaagtttga ggtaagtgta agggataggg gcagggacag 3060
ttggggatct gaaagtaggg gccagcctac tggctggtcc tcatgaccct ctctgcagta 3120
tattgggctg ggcgctgtgg ctgactgtgt gggtatcaac gtgaccgtgg gtggtgagag 3180
ctgccagcac gagttccggg gggacatggt tgtctgcccc ctgcccccat ccctgcagct 3240
tggccaggat ggtgccccat tgcaggtagg cagcccagct ggacctccct gggaaacacg 3300
ggcagagggc ctacaggctg ggcctgagtt gccacctgcc cccaggtctg cgtagatggt 3360
gaatgtcata tcctgggtag agtggtgcgg ccagggccag atggggtccc acagagcacg 3420
ctccttggta tcctgctgcc tttgctgctg cttgtggctg cactggcgac tgcactggtc 3480
ttcagctact ggtggcggag                                             3500

<210> 225
<211> 647
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR014E12

<400> 225
Met Glu Leu Leu Pro Pro Leu Pro Gln Ser Phe Leu Leu Leu Leu Leu
 1               5                  10                  15      
Leu Pro Ala Lys Pro Ala Ala Gly Glu Asp Trp Gln Cys Pro Arg Thr
            20                  25                  30          
Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val Lys Tyr Val Val Pro Ser
        35                  40                  45              
Phe Ser Ala Gly Gly Leu Val Gln Ala Met Val Thr Tyr Glu Gly Asp
    50                  55                  60                  
Arg Asn Glu Ser Ala Val Phe Val Ala Ile Arg Asn Arg Leu His Val
65                  70                  75                  80  
Leu Gly Pro Asp Leu Lys Ser Val Gln Ser Leu Ala Thr Gly Pro Ala
                85                  90                  95      
Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala Cys Gly Pro Gly Pro His
            100                 105                 110         
Gly Pro Pro Gly Asp Thr Asp Thr Lys Val Leu Val Leu Asp Pro Ala
        115                 120                 125             
Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe
    130                 135                 140                 
Leu His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro
145                 150                 155                 160 
Ala Cys Leu Phe Ser Ala His His Asn Arg Pro Asp Asp Cys Pro Asp
                165                 170                 175     
Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln Gly
            180                 185                 190         
Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Ala Ala Val Ala
        195                 200                 205             
Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ala Asp
    210                 215                 220                 
Ala Ser Gly Phe Ala Pro Gly Phe Val Ala Leu Ser Val Leu Pro Lys
225                 230                 235                 240 
His Leu Val Ser Tyr Ser Ile Glu Tyr Val His Ser Phe His Thr Gly
                245                 250                 255     
Ala Phe Val Tyr Phe Leu Thr Val Gln Pro Ala Ser Val Thr Asp Asp
            260                 265                 270         
Pro Ser Ala Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro
        275                 280                 285             
Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys Arg Phe Ala Pro
    290                 295                 300                 
Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Gly Gln Pro Tyr Pro Val
305                 310                 315                 320 
Leu Arg Val Ala His Ser Ala Pro Val Gly Ala Gln Leu Ala Thr Glu
                325                 330                 335     
Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val Thr
            340                 345                 350         
Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn Ser Val Val Cys Ala
        355                 360                 365             
Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp Glu Gly Val Glu Arg
    370                 375                 380                 
Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg Arg Gly Leu Asp Phe
385                 390                 395                 400 
Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Pro Gly Leu Glu Ala Leu
                405                 410                 415     
Ser Pro Asn Thr Ser Cys Arg His Phe Pro Leu Leu Val Ser Ser Ser
            420                 425                 430         
Phe Ser Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Pro Val Gln Val
        435                 440                 445             
Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn Val Thr Val Ala His Met
    450                 455                 460                 
Gly Thr Met Asp Gly Arg Ile Leu Gln Val Glu Leu Val Arg Ser Leu
465                 470                 475                 480 
Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Asp Ser Gly Gln
                485                 490                 495     
Pro Val Gln Arg Asp Val Ser Arg Leu Gly Asp His Leu Leu Phe Ala
            500                 505                 510         
Ser Gly Asp Gln Val Phe Gln Val Pro Ile Gln Gly Pro Gly Cys Arg
        515                 520                 525             
His Phe Leu Thr Cys Gly Arg Cys Leu Arg Ala Trp His Phe Met Gly
    530                 535                 540                 
Cys Gly Trp Cys Gly Asn Met Cys Gly Gln Gln Lys Glu Cys Pro Gly
545                 550                 555                 560 
Ser Trp Gln Gln Asp His Cys Pro Pro Lys Leu Thr Glu Phe His Pro
                565                 570                 575     
His Ser Gly Pro Leu Arg Gly Ser Thr Arg Leu Thr Leu Cys Gly Ser
            580                 585                 590         
Asn Phe Tyr Leu His Pro Ser Gly Leu Val Pro Glu Gly Thr His Gln
        595                 600                 605             
Val Thr Val Gly Gln Ser Pro Cys Arg Pro Leu Pro Lys Asp Ser Ser
    610                 615                 620                 
Lys Leu Arg Tyr Asn Leu Val Pro Pro Leu Pro Phe Pro Glu Gly Gly
625                 630                 635                 640 
Asn Gln Ala Ala Pro Ser Pro
                645         

<210> 226
<211> 1331
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (24)...(944)
<223> SR005A06

<400> 226
cctgccactt ccccaccgag gcc atg ggc cca gga gtt ctg ctg ctc ctg ctg 53
                          Met Gly Pro Gly Val Leu Leu Leu Leu Leu
                           1               5                   10
 
gtg gcc aca gct tgg cat ggt cag gga atc cca gtg ata gag ccc agt   101
Val Ala Thr Ala Trp His Gly Gln Gly Ile Pro Val Ile Glu Pro Ser
                 15                  20                  25
 
gtc cct gag ctg gtc gtg aag cca gga gca acg gtg acc ttg cga tgt   149
Val Pro Glu Leu Val Val Lys Pro Gly Ala Thr Val Thr Leu Arg Cys
             30                  35                  40
 
gtg ggc aat ggc agc gtg gaa tgg gat ggc ccc cca tca cct cac tgg   197
Val Gly Asn Gly Ser Val Glu Trp Asp Gly Pro Pro Ser Pro His Trp
         45                  50                  55
 
acc ctg tac tct gat ggc tcc agc agc atc ctc agc acc aac aac gct   245
Thr Leu Tyr Ser Asp Gly Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala
     60                  65                  70
 
acc ttc caa aac acg ggg acc tat cgc tgc act gag cct gga gac ccc   293
Thr Phe Gln Asn Thr Gly Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro
 75                  80                  85                  90
 
ctg gga ggc agc gcc gcc atc cac ctc tat gtc aaa gac cct gcc cgg   341
Leu Gly Gly Ser Ala Ala Ile His Leu Tyr Val Lys Asp Pro Ala Arg
                 95                 100                 105
 
ccc tgg aac gtg cta gca cag gag gtg gtc gtg ttc gag gac cag gac   389
Pro Trp Asn Val Leu Ala Gln Glu Val Val Val Phe Glu Asp Gln Asp
            110                 115                 120
 
gca cta ctg ccc tgt ctg ctc aca gac ccg gtg ctg gaa gca ggc gtc   437
Ala Leu Leu Pro Cys Leu Leu Thr Asp Pro Val Leu Glu Ala Gly Val
        125                 130                 135
 
tcg ctg gtg cgt gtg cgt ggc cgg ccc ctc atg cgc cac acc aac tac   485
Ser Leu Val Arg Val Arg Gly Arg Pro Leu Met Arg His Thr Asn Tyr
    140                 145                 150
 
tcc ttc tcg ccc tgg cat ggc ttc acc atc cac agg gcc aag ttc att   533
Ser Phe Ser Pro Trp His Gly Phe Thr Ile His Arg Ala Lys Phe Ile
155                 160                 165                 170
 
cag agc cag gac tat caa tgc agt gcc ctg atg ggt ggc agg aag gtg   581
Gln Ser Gln Asp Tyr Gln Cys Ser Ala Leu Met Gly Gly Arg Lys Val
                175                 180                 185
 
atg tcc atc agc atc cgg ctg aaa gtg cag aaa gtc atc cca ggg ccc   629
Met Ser Ile Ser Ile Arg Leu Lys Val Gln Lys Val Ile Pro Gly Pro
            190                 195                 200
 
cca gcc ttg aca ctg gtg cct gca gag ctg gtg cgg att cga ggg gag   677
Pro Ala Leu Thr Leu Val Pro Ala Glu Leu Val Arg Ile Arg Gly Glu
        205                 210                 215
 
gct gcc cag atc gtg tgc tca gcc agc agc gtt gat gtt aac ttt gat   725
Ala Ala Gln Ile Val Cys Ser Ala Ser Ser Val Asp Val Asn Phe Asp
    220                 225                 230
 
gtc ttc ctc caa cac aac aac acc aag ctc gca atc cct caa caa tct   773
Val Phe Leu Gln His Asn Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser
235                 240                 245                 250
 
gac ttt cat aat aac cgt tac caa aaa gtc ctg acc ctc aac ctc gat   821
Asp Phe His Asn Asn Arg Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp
                255                 260                 265
 
caa gta gat ttc caa cat gcc ggc aac tac tcc tgc gtg gcc agc aac   869
Gln Val Asp Phe Gln His Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn
            270                 275                 280
 
gtg cag ggc aag cac tcc acc tcc atg ttc ttc cgg gtg gta ggc aca   917
Val Gln Gly Lys His Ser Thr Ser Met Phe Phe Arg Val Val Gly Thr
        285                 290                 295
 
cct tca ccc tct ctc tgc ccc gcc tga agccctctga ggctggccgc         964
Pro Ser Pro Ser Leu Cys Pro Ala  *
    300                 305
 
tactccttcc tggccagaaa cccaggaggc tggagagctc tgacgtttga gctcaccctt 1024
cgataccccc cagaggtaag cgtcatatgg acattcatca acggctctgg cacccttttg 1084
tgtgctgcct ctgggtaccc ccagcccaac gtgacatggc tgcagtgcag tggccacact 1144
gataggtgtg atgaggccca agtgctgcag gtctgggatg acccataccc tgaggtcctg 1204
agccaggagc ccttccacaa ggtgacggtg cagagcctgc tgactgttga gaccttagag 1264
cacaaccaaa cctacgagtg cagggcccac aacagcgtgg ggagtggctc ctgggccttc 1324
ataccca                                                           1331

<210> 227
<211> 306
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR005A06

<400> 227
Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His
 1               5                  10                  15      
Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val
            20                  25                  30          
Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val
        35                  40                  45              
Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly
    50                  55                  60                  
Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly
65                  70                  75                  80  
Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala
                85                  90                  95      
Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala
            100                 105                 110         
Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu
        115                 120                 125             
Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg
    130                 135                 140                 
Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His
145                 150                 155                 160 
Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln
                165                 170                 175     
Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg
            180                 185                 190         
Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val
        195                 200                 205             
Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys
    210                 215                 220                 
Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn
225                 230                 235                 240 
Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg
                245                 250                 255     
Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His
            260                 265                 270         
Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser
        275                 280                 285             
Thr Ser Met Phe Phe Arg Val Val Gly Thr Pro Ser Pro Ser Leu Cys
    290                 295                 300                 
Pro Ala
305     

<210> 228
<211> 1582
<212> DNA
<213> Homo sapiens

<220> 
<223> SR002H01

<400> 228
gatcccatcg cagctaccgc gatgagaggc gctcgcggcg cctgggattt tctctgcgtt 60
ctgctcctac tgcttcgcgt ccagacaggc tcttctcaac catctgtgag tccaggggaa 120
ccgtctccac catccatcca tccaggaaaa tcagacttaa tagtccgcgt gggcgacgag 180
attaggctgt tatgcactga tccgggcttt gtcaaatgga cttttgagat cctggatgaa 240
acgaatgaga ataagcagaa tgaatggatc acggaaaagg cagaagccac caacaccggc 300
aaatacacgt gcaccaacaa acacggctta agcaattcca tttatgtgtt tgttagagat 360
cctgccaagc ttttccttgt tgaccgctcc ttgtatggga aagaagacaa cgacacgctg 420
gtccgctgtc ctctcacaga cccagaagtg accaattatt ccctcaaggg gtgccagggg 480
aagcctcttc ccaaggactt gaggtttatt cctgacccca aggcgggcat catgatcaaa 540
agtgtgaaac gcgcctacca tcggctctgt ctgcattgtt ctgtggacca ggagggcaag 600
tcagtgctgt cggaaaaatt catcctgaaa gtgaggccag ccttcaaagc tgtgcctgtt 660
gtgtctgtgt ccaaagcaag ctatcttctt agggaagggg aagaattcac agtgacgtgc 720
acaataaaag atgtgtctag ttctgtgtac tcaacgtgga aaagagaaaa cagtcagact 780
aaactacagg agaaatataa tagctggcat cacggtgact tcaattatga acgtcaggca 840
acgttgacta tcagttcagc gagagttaat gattctggag tgttcatgtg ttatgccaat 900
aatacttttg gatcagcaaa tgtcacaaca accttggaag tagtagataa aggattcatt 960
aatatcttcc ccatgataaa cactacagta tttgtaaacg atggagaaaa tgtagatttg 1020
attgttgaat atgaagcatt ccccaaacct gaacaccagc agtggatcta tatgaacaga 1080
accttcactg ataaatggga agattatccc aagtctgaga atgaaagtaa tatcagatac 1140
gtaagtgaac ttcatctaac gagattaaaa ggcaccgaag gaggcactta cacattccta 1200
gtgtccaatt ctgacgtcaa tgctgccata gcatttaatg tttatgtgaa tacttccctg 1260
taaatagagt gattcggctt ttaatcggca ccacccttcc acccccaaaa aggagaaaat 1320
tcatcaaaac cagaaatcct gacttacgac aggctcgtga atggcatgct ccaatgtgtg 1380
gcagcaggat tcccagagcc cacaatagat tggtattttt gtccaggaac tgagcagaga 1440
tgctctgctt ctgtactgcc agtggatgtg cagacactaa actcatctgg gccaccgttt 1500
ggaaagctag tggttcagag ttctatagat tctagtgcat tcaagcacaa tggcacggtt 1560
gaatgtaagg cttacaacga tg                                          1582

<210> 229
<211> 413
<212> PRT
<213> Homo sapiens

<220> 
<223> SR002H01

<400> 229
Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu
 1               5                  10                  15      
Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly
            20                  25                  30          
Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val
        35                  40                  45              
Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val
    50                  55                  60                  
Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn
65                  70                  75                  80  
Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr
                85                  90                  95      
Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg
            100                 105                 110         
Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu
        115                 120                 125             
Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr
    130                 135                 140                 
Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu
145                 150                 155                 160 
Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys
                165                 170                 175     
Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly
            180                 185                 190         
Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe
        195                 200                 205             
Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg
    210                 215                 220                 
Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser
225                 230                 235                 240 
Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln
                245                 250                 255     
Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln
            260                 265                 270         
Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe
        275                 280                 285             
Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr
    290                 295                 300                 
Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn
305                 310                 315                 320 
Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu
                325                 330                 335     
Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn
            340                 345                 350         
Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu
        355                 360                 365             
Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly
    370                 375                 380                 
Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn
385                 390                 395                 400 
Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Ser Leu
                405                 410             

<210> 230
<211> 217
<212> PRT
<213> Homo sapiens

<220> 
<223> PDGFRA.b BUILD 31

<400> 230
Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr
 1               5                  10                  15      
Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro
            20                  25                  30          
Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg
        35                  40                  45              
Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu
    50                  55                  60                  
Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu
65                  70                  75                  80  
Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly
                85                  90                  95      
Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu
            100                 105                 110         
Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe
        115                 120                 125             
Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp
    130                 135                 140                 
Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr
145                 150                 155                 160 
Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln
                165                 170                 175     
Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr
            180                 185                 190         
Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu
        195                 200                 205             
Lys Gly Thr Cys Ile Ile Ser Phe Leu
    210                 215         

<210> 231
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> PDGFRA.c BUILD 34

<400> 231
Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr
 1               5                  10                  15      
Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro
            20                  25                  30          
Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg
        35                  40                  45              
Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu
    50                  55                  60                  
Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu
65                  70                  75                  80  
Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly
                85                  90                  95      
Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu
            100                 105                 110         
Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe
        115                 120                 125             
Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp
    130                 135                 140                 
Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr
145                 150                 155                 160 
Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln
                165                 170                 175     
Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr
            180                 185                 190         
Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu
        195                 200                 205             
Lys Gly Thr Cys Ile Ile Ser Phe Leu Leu
    210                 215     

<210> 232
<211> 1508
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (7)...(1017)
<223> SR007C09

<400> 232
gacacc atg cgg ctt ccg ggt gcg atg cca gct ctg gcc ctc aaa ggc    48
       Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly
        1               5                   10
 
gag ctg ctg ttg ctg tct ctc ctg tta ctt ctg gaa cca cag atc tct   96
Glu Leu Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser
 15                  20                  25                  30
 
cag ggc ctg gtc gtc aca ccc ccg ggg cca gag ctt gtc ctc aat gtc   144
Gln Gly Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val
                 35                  40                  45
 
tcc agc acc ttc gtt ctg acc tgc tcg ggt tca gct ccg gtg gtg tgg   192
Ser Ser Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp
             50                  55                  60
 
gaa cgg atg tcc cag gag ccc cca cag gaa atg gcc aag gcc cag gat   240
Glu Arg Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp
         65                  70                  75
 
ggc acc ttc tcc agc gtg ctc aca ctg acc aac ctc act ggg cta gac   288
Gly Thr Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp
     80                  85                  90
 
acg gga gaa tac ttt tgc acc cac aat gac tcc cgt gga ctg gag acc   336
Thr Gly Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr
 95                 100                 105                 110
 
gat gag cgg aaa cgg ctc tac atc ttt gtg cca gat ccc acc gtg ggc   384
Asp Glu Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly
                115                 120                 125
 
ttc ctc cct aat gat gcc gag gaa cta ttc atc ttt ctc acg gaa ata   432
Phe Leu Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile
            130                 135                 140
 
act gag atc acc att cca tgc cga gta aca gac cca cag ctg gtg gtg   480
Thr Glu Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val
        145                 150                 155
 
aca ctg cac gag aag aaa ggg gac gtt gca ctg cct gtc ccc tat gat   528
Thr Leu His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp
    160                 165                 170
 
cac caa cgt ggc ttt tct ggt atc ttt gag gac aga agc tac atc tgc   576
His Gln Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys
175                 180                 185                 190
 
aaa acc acc att ggg gac agg gag gtg gat tct gat gcc tac tat gtc   624
Lys Thr Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val
                195                 200                 205
 
tac aga ctc cag gtg tca tcc atc aac gtc tct gtg aac gca gtg cag   672
Tyr Arg Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln
            210                 215                 220
 
act gtg gtc cgc cag ggt gag aac atc acc ctc atg tgc att gtg atc   720
Thr Val Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile
        225                 230                 235
 
ggg aat gag gtg gtc aac ttc gag tgg aca tac ccc cgc aaa gaa agt   768
Gly Asn Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser
    240                 245                 250
 
ggg cgg ctg gtg gag ccg gtg act gac ttc ctc ttg gat atg cct tac   816
Gly Arg Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr
255                 260                 265                 270
 
cac atc cgc tcc atc ctg cac atc ccc agt gcc gag tta gaa gac tcg   864
His Ile Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser
                275                 280                 285
 
ggg acc tac acc tgc aat gtg acg gag agt gtg aat gac cat cag gat   912
Gly Thr Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp
            290                 295                 300
 
gaa aag gcc atc aac atc acc gtg aga gcg gct acg tgc ggc tcc tgg   960
Glu Lys Ala Ile Asn Ile Thr Val Arg Ala Ala Thr Cys Gly Ser Trp
        305                 310                 315
 
gag agg tgg gca cac tac aat ttg ctg agc tgc atc gga gcc gga cac   1008
Glu Arg Trp Ala His Tyr Asn Leu Leu Ser Cys Ile Gly Ala Gly His
    320                 325                 330
 
tgc agg tag tgttcgaggc ctacccaccg cccactgtcc tgtggttcaa           1057
Cys Arg  *
335
 
agacaaccgc accctgggcg actccagcgc tggcgaaatc gccctgtcca cgcgcaacgt 1117
gtcggagacc cggtatgtgt cagagctgac actggttcgc gtgaaggtgg cagaggctgg 1177
ccactacacc atgcgggcct tccatgagga tgctgaggtc cagctctcct tccagctaca 1237
gatcaatgtc cctgtccgag tgctggagct aagtgagagc caccctgaca gtggggaaca 1297
gacagtccgc tgtcgtggcc ggggcatgcc ccagccgaac atcatctggt ctgcctgcag 1357
agacctcaaa aggtgtccac gtgagctgcc gcccacgctg ctggggaaca gttccgaaga 1417
ggagagccag ctggagacta acgtgacgta ctgggaggag gagcaggagt ttgaggtggt 1477
gagcacactg cgtctgcagc acgtggatcg g                                1508

<210> 233
<211> 336
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR007C09

<400> 233
Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu
 1               5                  10                  15      
Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly
            20                  25                  30          
Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser
        35                  40                  45              
Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg
    50                  55                  60                  
Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr
65                  70                  75                  80  
Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly
                85                  90                  95      
Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu
            100                 105                 110         
Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu
        115                 120                 125             
Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu
    130                 135                 140                 
Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu
145                 150                 155                 160 
His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln
                165                 170                 175     
Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr
            180                 185                 190         
Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg
        195                 200                 205             
Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val
    210                 215                 220                 
Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn
225                 230                 235                 240 
Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg
                245                 250                 255     
Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile
            260                 265                 270         
Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr
        275                 280                 285             
Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys
    290                 295                 300                 
Ala Ile Asn Ile Thr Val Arg Ala Ala Thr Cys Gly Ser Trp Glu Arg
305                 310                 315                 320 
Trp Ala His Tyr Asn Leu Leu Ser Cys Ile Gly Ala Gly His Cys Arg
                325                 330                 335     

<210> 234
<211> 928
<212> DNA
<213> Homo sapiens

<220> 
<223> SR021A05

<400> 234
caggaccctg gaaggaagca ggatggcagc cggaacagca gttggagcct gggtgctggt 60
cctcagtctg tggggggcag tagtaggtgc tcaaaacatc acagcccgga ttggcgagcc 120
actggtgctg aagtgtaagg gggcccccaa gaaaccaccc cagcggctgg aatggaaact 180
gaacacaggc cggacagaag cttggaaggt cctgtctccc cagggaggag gcccctggga 240
cagtgtggct cgtgtccttc ccaacggctc cctcttcctt ccggctgtcg ggatccagga 300
tgaggggatt ttccggtgcc aggcaatgaa caggaatgga aaggagacca agtccaacta 360
ccgagtccgt gtctaccgta agaattccag ggtcttctcc aaggcctccc tcttacctaa 420
gaaaaagcct tcaaccccag ccttggccca tgagggcctc tgacttccaa tctgaattcg 480
tcgacaagct tctcgagcct aggctagctc tagaccacac gtgtgggggc ccgagctcgc 540
ggccgctgta ttctatagtg tcacctaaat ggccgcacaa ttcactggcc gtcgttttac 600
aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca gcacatcccc 660
ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc 720
gcagcctgaa tggcgaatgg aaattgtaag cgttaatatt ttgttaaaat tcgcgttaaa 780
tttttgttaa atcagctcat tttttaacca ataggccgaa atcggcaaaa tcccttataa 840
atcaaaagaa tagaccgaga tagggttgag tgttgttcca gtttggaaca agagtccact 900
attaaagaac gtggactcca acgtcaaa                                    928

<210> 235
<211> 146
<212> PRT
<213> Homo sapiens

<220> 
<223> SR021A05

<400> 235
Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu
 1               5                  10                  15      
Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu
            20                  25                  30          
Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg
        35                  40                  45              
Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu
    50                  55                  60                  
Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro
65                  70                  75                  80  
Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile
                85                  90                  95      
Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn
            100                 105                 110         
Tyr Arg Val Arg Val Tyr Arg Lys Asn Ser Arg Val Phe Ser Lys Ala
        115                 120                 125             
Ser Leu Leu Pro Lys Lys Lys Pro Ser Thr Pro Ala Leu Ala His Glu
    130                 135                 140                 
Gly Leu
145     

<210> 236
<211> 994
<212> DNA
<213> Homo sapiens

<220> 
<223> SR021C02

<400> 236
aggaccctgg aaggaagcag gatggcagcc ggaacagcag ttggagcctg ggtgctggtc 60
ctcagtctgt ggggggcagt agtaggtgct caaaacatca cagcccggat tggcgagcca 120
ctggtgctga agtgtaaggg ggcccccaag aaaccacccc agcggctgga atggaaactg 180
aacacaggcc ggacagaagc ttggaaggtc ctgtctcccc agggaggagg cccctgggac 240
agtgtggctc gtgtccttcc caacggctcc ctcttccttc cggctgtcgg gatccaggat 300
gaggggattt tccggtgcca ggcaatgaac aggaatggaa aggagaccaa gtccaactac 360
cgagtccgtg tctaccagat tcctgggaag ccagaaattg tagattctgc ctctgaactc 420
acggctggtg ttcccaataa ggtagtggaa gaaagcagga gaagtagaaa acggccctgt 480
gaacaggagg tggggacatg tgtgtcagag ggaagctacc ctgcagggac tcttagctgg 540
cacttggatg ggaagcccct ggtgcctaat gagaagggag tatctgtgaa ggaacagacc 600
aggagacacc ctgagacagg gctcttcaca ctgcagtcgg agctaatggt gaccccagcc 660
cggggaggag atccccgtcc caccttctcc tgtagcttca gcccaggcct tccccgacac 720
cgggccttgc gcacagcccc catccagccc cgtgtctggg gtgagcatag gtggggaggg 780
ccccaagctc acgtgagcac gttctggaag tctgaccctt agggaaagag ggagtaatca 840
cgaattctgg atccgatacg taacgcgtct gcagcatgcg tggtaccgag ctttccctat 900
agtgagtcgt attagagctt ggccgtaatc atggtcatag ctgtttcctg tgtgaaattg 960
ttatccgctc acaatttcac acacatacga gccg                             994

<210> 237
<211> 266
<212> PRT
<213> Homo sapiens

<220> 
<223> SR021C02

<400> 237
Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu
 1               5                  10                  15      
Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu
            20                  25                  30          
Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg
        35                  40                  45              
Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu
    50                  55                  60                  
Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro
65                  70                  75                  80  
Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile
                85                  90                  95      
Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn
            100                 105                 110         
Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp
        115                 120                 125             
Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Val Glu Glu
    130                 135                 140                 
Ser Arg Arg Ser Arg Lys Arg Pro Cys Glu Gln Glu Val Gly Thr Cys
145                 150                 155                 160 
Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp
                165                 170                 175     
Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln
            180                 185                 190         
Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu
        195                 200                 205             
Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys
    210                 215                 220                 
Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro
225                 230                 235                 240 
Ile Gln Pro Arg Val Trp Gly Glu His Arg Trp Gly Gly Pro Gln Ala
                245                 250                 255     
His Val Ser Thr Phe Trp Lys Ser Asp Pro
            260                 265     


<210> 238
<211> 1165
<212> DNA
<213> Homo sapiens

<220> 
<223> SR021C06

<400> 238
atggcagccg gaacagcagt tggagcctgg gtgctggtcc tcagtctgtg gggggcagta 60
gtaggtgctc aaaacatcac agcccggatt ggcgagccac tggtgctgaa gtgtaagggg 120
gcccccaaga aaccacccca gcggctggaa tggaaactga acacaggccg gacagaagct 180
tggaaggtcc tgtctcccca gggaggaggc ccctgggaca gtgtggctcg tgtccttccc 240
aacggctccc tcttccttcc ggctgtcggg atccaggatg aggggatttt ccggtgccag 300
gcaatgaaca ggaatggaaa ggagaccaag tccaactacc gagtccgtgt ctaccagatt 360
cctgggaagc cagaaattgt agattctgcc tctgaactca cggctggtgt tcccaataag 420
gtggggacat gtgtgtcgga gggaagctac cctgcaggga ctcttagctg gcacttggat 480
gggaagcccc tggtgcctaa tgagaaggga gtatctgtga aggaacagac caggagacac 540
cctgagacag ggctcttcac actgcagtcg gagctaatgg tgaccccagc ccggggagga 600
gatccccgtc ccaccttctc ctgtagcttc agcccaggcc ttccccgaca ccgggccttg 660
cgcacagccc ccatccagcc ccgtgtctgg gagcctgtgc ctctggagga ggtccaattg 720
gtggtggagc cagaaggtgg agcagtagct cctggtggaa ccgtaaccct gacctgtgaa 780
gtccctgccc agccctctcc tcaaatccac tggatgaagg atggggtgcc cttgcccctt 840
ccccccagcc ctgtgctgat cctccctgag atagggcctc aggaccaggg aacctacagc 900
tgtgtggcca cccattccag ccacgggccc caggaaagcc gtgctgtcag catcagcatc 960
atcggtgaga cctctcccca agccctacag accctgggac tagggtgcag gacagcacag 1020
gctctaattt cctgccccat tctggcctta tccctaacag ccaccccacc tctccctcca 1080
tgcacccaca cccaagcctc ccctgcccca cccaaattct gccaagagag cagccaagcc 1140
tctcccttct tccctctgag ctaaa                                       1165

<210> 239
<211> 387
<212> PRT
<213> Homo sapiens

<220> 
<223> SR021C06

<400> 239
Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu
 1               5                  10                  15      
Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu
            20                  25                  30          
Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg
        35                  40                  45              
Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu
    50                  55                  60                  
Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro
65                  70                  75                  80  
Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile
                85                  90                  95      
Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn
            100                 105                 110         
Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp
        115                 120                 125             
Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys
    130                 135                 140                 
Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp
145                 150                 155                 160 
Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln
                165                 170                 175     
Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu
            180                 185                 190         
Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys
        195                 200                 205             
Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro
    210                 215                 220                 
Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu
225                 230                 235                 240 
Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr
                245                 250                 255     
Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met
            260                 265                 270         
Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu
        275                 280                 285             
Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr
    290                 295                 300                 
His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile
305                 310                 315                 320 
Ile Gly Glu Thr Ser Pro Gln Ala Leu Gln Thr Leu Gly Leu Gly Cys
                325                 330                 335     
Arg Thr Ala Gln Ala Leu Ile Ser Cys Pro Ile Leu Ala Leu Ser Leu
            340                 345                 350         
Thr Ala Thr Pro Pro Leu Pro Pro Cys Thr His Thr Gln Ala Ser Pro
        355                 360                 365             
Ala Pro Pro Lys Phe Cys Gln Glu Ser Ser Gln Ala Ser Pro Phe Phe
    370                 375                 380                 
Pro Leu Ser
385         

<210> 240
<211> 1415
<212> DNA
<213> Homo sapiens

<220> 
<223> SR021C08

<400> 240
atggcagccg gaacagcagt tggagcctgg gtgctggtcc tcagtctgtg gggggcagta 60
gtaggtgctc aaaacatcac agcccggatt ggcgagccac tggtgctgaa gtgtaagggg 120
gcccccaaga aaccacccca gcggctggaa tggaaactga acacaggccg gacagaagct 180
tggaaggtcc tgtctcccca gggaggaggc ccctgggaca gtgtggctcg tgtccttccc 240
aacggctccc tcttccttcc ggctgtcggg atccaggatg aggggatttt ccggtgccag 300
gcaatgaaca ggaatggaaa ggagaccaag tccaactacc gagtccgtgt ctaccagatt 360
cctgggaagc cagaaattgt agattctgcc tctgaactca cggctggtgt tcccaataag 420
gtagtggaag aaagcaggag aagtagaaaa cggccctgtg aacaggaggc gagtgtgtgt 480
gggtgtgggt gtgtggcatc tctcattttc aaaggattct gaggtcacca ctctttcccc 540
aggtggggac atgtgtgtca gagggaagct accctgcagg gactcttagc tggcacttgg 600
atgggaagcc cctggtgcct aatgagaagg gagtatctgt gaaggaacag accaggagac 660
accctgagac agggctcttc acactgcagt cggagctaat ggtgacccca gcccggggag 720
gagatccccg tcccaccttc tcctgtagct tcagcccagg ccttccccga caccgggcct 780
tgcgcacagc ccccatccag ccccgtgtct ggggtgagca taggtgggga gggccccaag 840
ctcacgtgag cacgttctgg aagtctgacc cttagggaaa gagggagtca agcccatggc 900
cactgggatc actcacaagt gtaactctcc acctcaaaac ccttccaact cccagagcct 960
gtgcctctgg aggaggtcca attggtggtg gagccagaag gtggagcagt agctcctggt 1020
ggaaccgtaa ccctgacctg tgaagtccct gcccagccct ctcctcaaat ccactggatg 1080
aaggatggtg tgcccttgcc ccttcccccc agccctgtgc tgatcctccc tgagataggg 1140
cctcaggacc agggaaccta cagctgtgtg gccacccatt ccagccacgg gccccaggaa 1200
agccgtgctg tcagcatcag catcatcgaa ccaggcaagg aggggccaac tgcaggtgag 1260
gggtttgata aagtcaggga agcagaagat agcccccaac acatgtgact ggggggatgg 1320
tcaacaagaa aggaatggaa ggccccagaa aaccaggagg aagaggagga gcgtgcagaa 1380
ctgaatcagt cggaggaacc tgaggcaggc gagaa                            1415

<210> 241
<211> 173
<212> PRT
<213> Homo sapiens

<220> 
<223> SR021C08

<400> 241
Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu
 1               5                  10                  15      
Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu
            20                  25                  30          
Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg
        35                  40                  45              
Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu
    50                  55                  60                  
Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro
65                  70                  75                  80  
Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile
                85                  90                  95      
Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn
            100                 105                 110         
Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp
        115                 120                 125             
Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Val Glu Glu
    130                 135                 140                 
Ser Arg Arg Ser Arg Lys Arg Pro Cys Glu Gln Glu Ala Ser Val Cys
145                 150                 155                 160 
Gly Cys Gly Cys Val Ala Ser Leu Ile Phe Lys Gly Phe
                165                 170             

<210> 242
<211> 941
<212> DNA
<213> Homo sapiens

<220> 
<223> SR021F06

<400> 242
aggaccctgg aaggaagcag gatggcagcc ggaacagcag ttggagcctg ggtgctggtc 60
ctcagtctgt ggggggcagt agtaggtgct caaaacatca cagcccggat tggcgagcca 120
ctggtgctga agtgtaaggg ggcccccaag aaaccacccc agcggctgga atggaaactg 180
aacacaggcc ggacagaagc ttggaaggtc ctgtctcccc agggaggagg cccctgggac 240
agtgtggctc gtgtccttcc caacggctcc ctcttccttc cggctgtcgg gatccaggat 300
gaggggattt tccggtgcca ggcaatgaac aggaatggaa aggagaccaa gtccaactac 360
cgagtccgtg tctaccagat tcctgggaag ccagaaattg tagattctgc ctctgaactc 420
acggctggtg ttcccaataa ggtggggaca tgtgtgtcag agggaagcta ccctgcaggg 480
actcttagct ggcacttgga tgggaagccc ctggtgccta atgagaaggg tgagtcctaa 540
ggtgcccccc aagaatcacg aattctggat ccgatacgta acgcgtctgc agcatgcgtg 600
gtaccgagct ttccctatag tgagtcgtat tagagcttgg cgtaatcatg gtcatagctg 660
tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata 720
aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca 780
ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc 840
gcggggagag gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg 900
cgctcggtcg ttcggctgcg gcgagcggta tcagctcact c                     941

<210> 243
<211> 172
<212> PRT
<213> Homo sapiens

<220> 
<223> SR021F06

<400> 243
Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu
 1               5                  10                  15      
Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu
            20                  25                  30          
Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg
        35                  40                  45              
Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu
    50                  55                  60                  
Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro
65                  70                  75                  80  
Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile
                85                  90                  95      
Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn
            100                 105                 110         
Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp
        115                 120                 125             
Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys
    130                 135                 140                 
Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp
145                 150                 155                 160 
Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Glu Ser
                165                 170         


<210> 244
<211> 1505
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (41)...(1144)
<223> SR007G02

<400> 244
tgcacatttg tggaaactgg atggagagat ttggggaagc atg gac tct tta gcc   55
                                             Met Asp Ser Leu Ala
                                              1               5
 
agc tta gtt ctc tgt gga gtc agc ttg ctc ctt tct gga act gtg gaa   103
Ser Leu Val Leu Cys Gly Val Ser Leu Leu Leu Ser Gly Thr Val Glu
                 10                  15                  20
 
ggt gcc atg gac ttg atc ttg atc aat tcc cta cct ctt gta tct gat   151
Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu Pro Leu Val Ser Asp
             25                  30                  35
 
gct gaa aca tct ctc acc tgc att gcc tct ggg tgg cgc ccc cat gag   199
Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly Trp Arg Pro His Glu
         40                  45                  50
 
ccc atc acc ata gga agg gac ttt gaa gcc tta atg aac cag cac cag   247
Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu Met Asn Gln His Gln
     55                  60                  65
 
gat ccg ctg gaa gtt act caa gat gtg acc aga gaa tgg gct aaa aaa   295
Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg Glu Trp Ala Lys Lys
 70                  75                  80                  85
 
gtt gtt tgg aag aga gaa aag gct agt aag atc aat ggt gct tat ttc   343
Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile Asn Gly Ala Tyr Phe
                 90                  95                 100
 
tgt gaa ggg cga gtt cga gga gag gca atc agg ata cga acc atg aag   391
Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg Ile Arg Thr Met Lys
            105                 110                 115
 
atg cgt caa caa gct tcc ttc cta cca gct act tta act atg act gtg   439
Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr Leu Thr Met Thr Val
        120                 125                 130
 
gac aag gga gat aac gtg aac ata tct ttc aaa aag gta ttg att aaa   487
Asp Lys Gly Asp Asn Val Asn Ile Ser Phe Lys Lys Val Leu Ile Lys
    135                 140                 145
 
gaa gaa gat gca gtg att tac aaa aat ggt tcc ttc atc cat tca gtg   535
Glu Glu Asp Ala Val Ile Tyr Lys Asn Gly Ser Phe Ile His Ser Val
150                 155                 160                 165
 
ccc cgg cat gaa gta cct gat att cta gaa gta cac ctg cct cat gct   583
Pro Arg His Glu Val Pro Asp Ile Leu Glu Val His Leu Pro His Ala
                170                 175                 180
 
cag ccc cag gat gct gga gtg tac tcg gcc agg tat ata gga gga aac   631
Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg Tyr Ile Gly Gly Asn
            185                 190                 195
 
ctc ttc acc tcg gcc ttc acc agg ctg ata gtc cgg aga tgt gaa gcc   679
Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val Arg Arg Cys Glu Ala
        200                 205                 210
 
cag aag tgg gga cct gaa tgc aac cat ctc tgt act gct tgt atg aac   727
Gln Lys Trp Gly Pro Glu Cys Asn His Leu Cys Thr Ala Cys Met Asn
    215                 220                 225
 
aat ggt gtc tgc cat gaa gat act gga gaa tgc att tgc cct cct ggg   775
Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys Ile Cys Pro Pro Gly
230                 235                 240                 245
 
ttt atg gga agg acg tgt gag aag gct tgt gaa ctg cac acg ttt ggc   823
Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu Leu His Thr Phe Gly
                250                 255                 260
 
aga act tgt aaa gaa agg tgc agt gga caa gag gga tgc aag tct tat   871
Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Glu Gly Cys Lys Ser Tyr
            265                 270                 275
 
gtg ttc tgt ctc cct gac ccc tat ggg tgt tcc tgt gcc aca ggc tgg   919
Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser Cys Ala Thr Gly Trp
        280                 285                 290
 
aag ggt ctg cag tgc aat gaa gca tgc cac cct ggt ttt tac ggg cca   967
Lys Gly Leu Gln Cys Asn Glu Ala Cys His Pro Gly Phe Tyr Gly Pro
    295                 300                 305
 
gat tgt aag ctt agg tgc agc tgc aac aat ggg gag atg tgt gat cgc   1015
Asp Cys Lys Leu Arg Cys Ser Cys Asn Asn Gly Glu Met Cys Asp Arg
310                 315                 320                 325
 
ttc caa gga tgt ctc tgc tct cca gga tgg cag ggg ctc cag tgt gag   1063
Phe Gln Gly Cys Leu Cys Ser Pro Gly Trp Gln Gly Leu Gln Cys Glu
                330                 335                 340
 
aga gaa ggt aaa gca agg cat aca gag gat gac ccc aaa gat agt gga   1111
Arg Glu Gly Lys Ala Arg His Thr Glu Asp Asp Pro Lys Asp Ser Gly
            345                 350                 355
 
ttt gcc aga tca tat aga agt aaa cag tgg taa atttaatccc atttgcaaag 1164
Phe Ala Arg Ser Tyr Arg Ser Lys Gln Trp  *
        360                 365
 
cttctggctg gccgctacct actaatgaag aaatgaccct ggtgaagccg gatgggacag 1224
tgctccatta gccatattca ccatccaccg gatcctcccc cctgactcag gagtttgggt 1284
ctgcagtgtg aacacagtgg ctgggatggt ggaaaagccc ttcaacattt ctgttaaagt 1344
tcttccaaag cccctgaatg ccccaaacgt gattgacact ggacataact ttgctgtcat 1404
caacatcagc tctgagcctt actttgggga tggaccaatc aaatccaaga agcttctata 1464
caaacccgtt aatcactatg aggcttggca acatattcaa g                     1505

<210> 245
<211> 367
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR007G02

<400> 245
Met Asp Ser Leu Ala Ser Leu Val Leu Cys Gly Val Ser Leu Leu Leu
 1               5                  10                  15      
Ser Gly Thr Val Glu Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu
            20                  25                  30          
Pro Leu Val Ser Asp Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly
        35                  40                  45              
Trp Arg Pro His Glu Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu
    50                  55                  60                  
Met Asn Gln His Gln Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg
65                  70                  75                  80  
Glu Trp Ala Lys Lys Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile
                85                  90                  95      
Asn Gly Ala Tyr Phe Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg
            100                 105                 110         
Ile Arg Thr Met Lys Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr
        115                 120                 125             
Leu Thr Met Thr Val Asp Lys Gly Asp Asn Val Asn Ile Ser Phe Lys
    130                 135                 140                 
Lys Val Leu Ile Lys Glu Glu Asp Ala Val Ile Tyr Lys Asn Gly Ser
145                 150                 155                 160 
Phe Ile His Ser Val Pro Arg His Glu Val Pro Asp Ile Leu Glu Val
                165                 170                 175     
His Leu Pro His Ala Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg
            180                 185                 190         
Tyr Ile Gly Gly Asn Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val
        195                 200                 205             
Arg Arg Cys Glu Ala Gln Lys Trp Gly Pro Glu Cys Asn His Leu Cys
    210                 215                 220                 
Thr Ala Cys Met Asn Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys
225                 230                 235                 240 
Ile Cys Pro Pro Gly Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu
                245                 250                 255     
Leu His Thr Phe Gly Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Glu
            260                 265                 270         
Gly Cys Lys Ser Tyr Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser
        275                 280                 285             
Cys Ala Thr Gly Trp Lys Gly Leu Gln Cys Asn Glu Ala Cys His Pro
    290                 295                 300                 
Gly Phe Tyr Gly Pro Asp Cys Lys Leu Arg Cys Ser Cys Asn Asn Gly
305                 310                 315                 320 
Glu Met Cys Asp Arg Phe Gln Gly Cys Leu Cys Ser Pro Gly Trp Gln
                325                 330                 335     
Gly Leu Gln Cys Glu Arg Glu Gly Lys Ala Arg His Thr Glu Asp Asp
            340                 345                 350         
Pro Lys Asp Ser Gly Phe Ala Arg Ser Tyr Arg Ser Lys Gln Trp
        355                 360                 365         

<210> 246
<211> 1467
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (41)...(1447)
<223> SR007H03

<400> 246
tgcacatttg tggaaactgg atggagagat ttggggaagc atg gac tct tta gcc   55
                                             Met Asp Ser Leu Ala
                                              1               5
 
agc tta gtt ctc tgt gga gtc agc ttg ctc ctt tct gga act gtg gaa   103
Ser Leu Val Leu Cys Gly Val Ser Leu Leu Leu Ser Gly Thr Val Glu
                 10                  15                  20
 
ggt gcc atg gac ttg atc ttg atc aat tcc cta cct ctt gta tct gat   151
Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu Pro Leu Val Ser Asp
             25                  30                  35
 
gct gaa aca tct ctc acc tgc att gcc tct ggg tgg cgc ccc cat gag   199
Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly Trp Arg Pro His Glu
         40                  45                  50
 
ccc atc acc ata gga agg gac ttt gaa gcc tta atg aac cag cac cag   247
Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu Met Asn Gln His Gln
     55                  60                  65
 
gat ccg ctg gaa gtt act caa gat gtg acc aga gaa tgg gct aaa aaa   295
Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg Glu Trp Ala Lys Lys
 70                  75                  80                  85
 
gtt gtt tgg aag aga gaa aag gct agt aag atc aat ggt gct tat ttc   343
Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile Asn Gly Ala Tyr Phe
                 90                  95                 100
 
tgt gaa ggg cga gtt cga gga gag gca atc agg ata cga acc atg aag   391
Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg Ile Arg Thr Met Lys
            105                 110                 115
 
atg cgt caa caa gct tcc ttc cta cca gct act tta act atg act gtg   439
Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr Leu Thr Met Thr Val
        120                 125                 130
 
gac aag gga gat aac gtg aac ata tct ttc aaa aag gta ttg att aaa   487
Asp Lys Gly Asp Asn Val Asn Ile Ser Phe Lys Lys Val Leu Ile Lys
    135                 140                 145
 
gaa gaa gat gca gtg att tac aaa aat ggt tcc ttc atc cat tca gtg   535
Glu Glu Asp Ala Val Ile Tyr Lys Asn Gly Ser Phe Ile His Ser Val
150                 155                 160                 165
 
ccc cgg cat gaa gta cct gat att cta gaa gta cac ctg cct cat gct   583
Pro Arg His Glu Val Pro Asp Ile Leu Glu Val His Leu Pro His Ala
                170                 175                 180
 
cag ccc cag gat gct gga gtg tac tcg gcc agg tat ata gga gga aac   631
Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg Tyr Ile Gly Gly Asn
            185                 190                 195
 
ctc ttc acc tcg gcc ttc acc agg ctg ata gtc cgg aga tgt gaa gcc   679
Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val Arg Arg Cys Glu Ala
        200                 205                 210
 
cag aag tgg gga cct gaa tgc aac cat ctc tgt act gct tgt atg aac   727
Gln Lys Trp Gly Pro Glu Cys Asn His Leu Cys Thr Ala Cys Met Asn
    215                 220                 225
 
aat ggt gtc tgc cat gaa gat act gga gaa tgc att tgc cct cct ggg   775
Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys Ile Cys Pro Pro Gly
230                 235                 240                 245
 
ttt atg gga agg acg tgt gag aag gct tgt gaa ctg cac acg ttt ggc   823
Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu Leu His Thr Phe Gly
                250                 255                 260
 
aga act tgt aaa gaa agg tgc agt gga caa gag gga tgc aag tct tat   871
Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Glu Gly Cys Lys Ser Tyr
            265                 270                 275
 
gtg ttc tgt ctc cct gac ccc tat ggg tgt tcc tgt gcc aca ggc tgg   919
Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser Cys Ala Thr Gly Trp
        280                 285                 290
 
aag ggt ctg cag tgc aat gaa ggc ata cag agg atg acc cca aag ata   967
Lys Gly Leu Gln Cys Asn Glu Gly Ile Gln Arg Met Thr Pro Lys Ile
    295                 300                 305
 
gtg gat ttg cca gat cat ata gaa gta aac agt ggt aaa ttt aat ccc   1015
Val Asp Leu Pro Asp His Ile Glu Val Asn Ser Gly Lys Phe Asn Pro
310                 315                 320                 325
 
att tgc aaa gct tct ggc tgg ccg cta cct act aat gaa gaa atg acc   1063
Ile Cys Lys Ala Ser Gly Trp Pro Leu Pro Thr Asn Glu Glu Met Thr
                330                 335                 340
 
ctg gtg aag ccg gat ggg aca gtg ctc cat cca aaa gac ttt aac cat   1111
Leu Val Lys Pro Asp Gly Thr Val Leu His Pro Lys Asp Phe Asn His
            345                 350                 355
 
acg gat cat ttc tca gta gcc ata ttc acc atc cac cgg atc ctc ccc   1159
Thr Asp His Phe Ser Val Ala Ile Phe Thr Ile His Arg Ile Leu Pro
        360                 365                 370
 
cct gac tca gga gtt tgg gtc tgc agt gtg aac aca gtg gct ggg atg   1207
Pro Asp Ser Gly Val Trp Val Cys Ser Val Asn Thr Val Ala Gly Met
    375                 380                 385
 
gtg gaa aag ccc ttc aac att tct gtt aaa gtt ctt cca aag ccc ctg   1255
Val Glu Lys Pro Phe Asn Ile Ser Val Lys Val Leu Pro Lys Pro Leu
390                 395                 400                 405
 
aat gcc cca aac gtg att gac act gga cat aac ttt gct gtc atc aac   1303
Asn Ala Pro Asn Val Ile Asp Thr Gly His Asn Phe Ala Val Ile Asn
                410                 415                 420
 
atc agc tct gag cct tac ttt ggg gat gga cca atc aaa tcc aag aag   1351
Ile Ser Ser Glu Pro Tyr Phe Gly Asp Gly Pro Ile Lys Ser Lys Lys
            425                 430                 435
 
ctt cta tac aaa ccc gtt aat cac tat gag gct tgg caa cat att caa   1399
Leu Leu Tyr Lys Pro Val Asn His Tyr Glu Ala Trp Gln His Ile Gln
        440                 445                 450
 
gta tcc atg gag aaa cag agg ctg act aaa gca aat agt gac aaa tga   1447
Val Ser Met Glu Lys Gln Arg Leu Thr Lys Ala Asn Ser Asp Lys  *
    455                 460                 465
 
gattgttaca ctcaactatt                                             1467

<210> 247
<211> 468
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR007H03

<400> 247
Met Asp Ser Leu Ala Ser Leu Val Leu Cys Gly Val Ser Leu Leu Leu
 1               5                  10                  15      
Ser Gly Thr Val Glu Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu
            20                  25                  30          
Pro Leu Val Ser Asp Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly
        35                  40                  45              
Trp Arg Pro His Glu Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu
    50                  55                  60                  
Met Asn Gln His Gln Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg
65                  70                  75                  80  
Glu Trp Ala Lys Lys Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile
                85                  90                  95      
Asn Gly Ala Tyr Phe Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg
            100                 105                 110         
Ile Arg Thr Met Lys Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr
        115                 120                 125             
Leu Thr Met Thr Val Asp Lys Gly Asp Asn Val Asn Ile Ser Phe Lys
    130                 135                 140                 
Lys Val Leu Ile Lys Glu Glu Asp Ala Val Ile Tyr Lys Asn Gly Ser
145                 150                 155                 160 
Phe Ile His Ser Val Pro Arg His Glu Val Pro Asp Ile Leu Glu Val
                165                 170                 175     
His Leu Pro His Ala Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg
            180                 185                 190         
Tyr Ile Gly Gly Asn Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val
        195                 200                 205             
Arg Arg Cys Glu Ala Gln Lys Trp Gly Pro Glu Cys Asn His Leu Cys
    210                 215                 220                 
Thr Ala Cys Met Asn Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys
225                 230                 235                 240 
Ile Cys Pro Pro Gly Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu
                245                 250                 255     
Leu His Thr Phe Gly Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Glu
            260                 265                 270         
Gly Cys Lys Ser Tyr Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser
        275                 280                 285             
Cys Ala Thr Gly Trp Lys Gly Leu Gln Cys Asn Glu Gly Ile Gln Arg
    290                 295                 300                 
Met Thr Pro Lys Ile Val Asp Leu Pro Asp His Ile Glu Val Asn Ser
305                 310                 315                 320 
Gly Lys Phe Asn Pro Ile Cys Lys Ala Ser Gly Trp Pro Leu Pro Thr
                325                 330                 335     
Asn Glu Glu Met Thr Leu Val Lys Pro Asp Gly Thr Val Leu His Pro
            340                 345                 350         
Lys Asp Phe Asn His Thr Asp His Phe Ser Val Ala Ile Phe Thr Ile
        355                 360                 365             
His Arg Ile Leu Pro Pro Asp Ser Gly Val Trp Val Cys Ser Val Asn
    370                 375                 380                 
Thr Val Ala Gly Met Val Glu Lys Pro Phe Asn Ile Ser Val Lys Val
385                 390                 395                 400 
Leu Pro Lys Pro Leu Asn Ala Pro Asn Val Ile Asp Thr Gly His Asn
                405                 410                 415     
Phe Ala Val Ile Asn Ile Ser Ser Glu Pro Tyr Phe Gly Asp Gly Pro
            420                 425                 430         
Ile Lys Ser Lys Lys Leu Leu Tyr Lys Pro Val Asn His Tyr Glu Ala
        435                 440                 445             
Trp Gln His Ile Gln Val Ser Met Glu Lys Gln Arg Leu Thr Lys Ala
    450                 455                 460                 
Asn Ser Asp Lys
465             

<210> 248
<211> 864
<212> PRT
<213> Homo sapiens

<220> 
<223> TEKc

<400> 248
Met Asp Ser Leu Ala Ser Leu Val Leu Cys Gly Val Ser Leu Leu Leu
 1               5                  10                  15      
Ser Gly Thr Val Glu Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu
            20                  25                  30          
Pro Leu Val Ser Asp Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly
        35                  40                  45              
Trp Arg Pro His Glu Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu
    50                  55                  60                  
Met Asn Gln His Gln Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg
65                  70                  75                  80  
Glu Trp Ala Lys Lys Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile
                85                  90                  95      
Asn Gly Ala Tyr Phe Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg
            100                 105                 110         
Ile Arg Thr Met Lys Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr
        115                 120                 125             
Leu Thr Met Thr Val Asp Lys Gly Asp Asn Val Asn Ile Ser Phe Lys
    130                 135                 140                 
Lys Val Leu Ile Lys Glu Glu Asp Ala Val Ile Tyr Lys Asn Gly Ser
145                 150                 155                 160 
Phe Ile His Ser Val Pro Arg His Glu Val Pro Asp Ile Leu Glu Val
                165                 170                 175     
His Leu Pro His Ala Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg
            180                 185                 190         
Tyr Ile Gly Gly Asn Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val
        195                 200                 205             
Arg Arg Cys Glu Ala Gln Lys Trp Gly Pro Glu Cys Asn His Leu Cys
    210                 215                 220                 
Thr Ala Cys Met Asn Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys
225                 230                 235                 240 
Ile Cys Pro Pro Gly Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu
                245                 250                 255     
Leu His Thr Phe Gly Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Glu
            260                 265                 270         
Gly Cys Lys Ser Tyr Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser
        275                 280                 285             
Cys Ala Thr Gly Trp Lys Gly Leu Gln Cys Asn Glu Ala Cys His Pro
    290                 295                 300                 
Gly Phe Tyr Gly Pro Asp Cys Lys Leu Arg Cys Ser Cys Asn Asn Gly
305                 310                 315                 320 
Glu Met Cys Asp Arg Phe Gln Gly Cys Leu Cys Ser Pro Gly Trp Gln
                325                 330                 335     
Gly Leu Gln Cys Glu Arg Glu Gly Ile Gln Arg Met Thr Pro Lys Ile
            340                 345                 350         
Val Asp Leu Pro Asp His Ile Glu Val Asn Ser Gly Lys Phe Asn Pro
        355                 360                 365             
Ile Cys Lys Ala Ser Gly Trp Pro Leu Pro Thr Asn Glu Glu Met Thr
    370                 375                 380                 
Leu Val Lys Pro Asp Gly Thr Val Leu His Pro Lys Asp Phe Asn His
385                 390                 395                 400 
Thr Asp His Phe Ser Val Ala Ile Phe Thr Ile His Arg Ile Leu Pro
                405                 410                 415     
Pro Asp Ser Gly Val Trp Val Cys Ser Val Asn Thr Val Ala Gly Met
            420                 425                 430         
Val Glu Lys Pro Phe Asn Ile Ser Val Lys Val Leu Pro Lys Pro Leu
        435                 440                 445             
Asn Ala Pro Asn Val Ile Asp Thr Gly His Asn Phe Ala Val Ile Asn
    450                 455                 460                 
Ile Ser Ser Glu Pro Tyr Phe Gly Asp Gly Pro Ile Lys Ser Lys Lys
465                 470                 475                 480 
Leu Leu Tyr Lys Pro Val Asn His Tyr Glu Ala Trp Gln His Ile Gln
                485                 490                 495     
Val Thr Asn Glu Ile Val Thr Leu Asn Tyr Leu Glu Pro Arg Thr Glu
            500                 505                 510         
Tyr Glu Leu Cys Val Gln Leu Val Arg Arg Gly Glu Gly Gly Glu Gly
        515                 520                 525             
His Pro Gly Pro Val Arg Arg Phe Thr Thr Ala Ser Ile Gly Leu Pro
    530                 535                 540                 
Pro Pro Arg Gly Leu Asn Leu Leu Pro Lys Ser Gln Thr Thr Leu Asn
545                 550                 555                 560 
Leu Thr Trp Gln Pro Ser Ser Glu Asp Asp Phe Tyr Val Glu Val Glu
                565                 570                 575     
Arg Arg Ser Val Gln Lys Ser Asp Gln Gln Asn Ile Lys Val Pro Gly
            580                 585                 590         
Asn Leu Thr Ser Val Leu Leu Asn Asn Leu His Pro Arg Glu Gln Tyr
        595                 600                 605             
Val Val Arg Ala Arg Val Asn Thr Lys Ala Gln Gly Glu Trp Ser Glu
    610                 615                 620                 
Asp Leu Thr Ala Trp Thr Leu Ser Asp Ile Leu Pro Pro Gln Pro Glu
625                 630                 635                 640 
Asn Ile Lys Ile Ser Asn Ile Thr His Ser Ser Ala Val Ile Ser Trp
                645                 650                 655     
Thr Ile Leu Asp Gly Tyr Ser Ile Ser Ser Ile Thr Ile Arg Tyr Lys
            660                 665                 670         
Val Gln Gly Lys Asn Glu Asp Gln His Val Asp Val Lys Ile Lys Asn
        675                 680                 685             
Ala Thr Ile Thr Gln Tyr Gln Leu Lys Gly Leu Glu Pro Glu Thr Ala
    690                 695                 700                 
Tyr Gln Val Asp Ile Phe Ala Glu Asn Asn Ile Gly Ser Ser Asn Pro
705                 710                 715                 720 
Ala Phe Ser His Glu Leu Val Thr Leu Pro Glu Ser Gln Ala Pro Ala
                725                 730                 735     
Asp Leu Gly Gly Gly Lys Met Leu Leu Ile Ala Ile Leu Gly Ser Ala
            740                 745                 750         
Gly Met Thr Cys Leu Thr Val Leu Leu Ala Phe Leu Ile Ile Leu Gln
        755                 760                 765             
Leu Lys Arg Ala Asn Val Gln Arg Arg Met Ala Gln Ala Phe Gln Asn
    770                 775                 780                 
Val Arg Glu Glu Pro Ala Val Gln Phe Asn Ser Gly Thr Leu Ala Leu
785                 790                 795                 800 
Asn Arg Lys Val Lys Asn Asn Pro Asp Pro Thr Ile Tyr Pro Val Leu
                805                 810                 815     
Asp Trp Asn Asp Ile Lys Phe Gln Asp Val Ile Gly Glu Gly Asn Phe
            820                 825                 830         
Gly Gln Val Leu Lys Ala Arg Ile Lys Lys Asp Gly Leu Arg Met Asp
        835                 840                 845             
Ala Ala Ile Lys Arg Met Lys Glu Tyr Ala Ser Lys Asp Asp His Arg
    850                 855                 860                 

<210> 249
<211> 798
<212> PRT
<213> Homo sapiens

<220> 
<223> TEKc 31

<400> 249
Met Asp Leu Ile Leu Ile Asn Ser Leu Pro Leu Val Ser Asp Ala Glu
 1               5                  10                  15      
Thr Ser Leu Thr Cys Ile Ala Ser Gly Trp Arg Pro His Glu Pro Ile
            20                  25                  30          
Thr Ile Gly Arg Asp Phe Glu Ala Leu Met Asn Gln His Gln Asp Pro
        35                  40                  45              
Leu Glu Val Thr Gln Asp Val Thr Arg Glu Trp Ala Lys Lys Val Val
    50                  55                  60                  
Trp Lys Arg Glu Lys Ala Ser Lys Ile Asn Gly Ala Tyr Phe Cys Glu
65                  70                  75                  80  
Gly Arg Val Arg Gly Glu Ala Ile Arg Ile Arg Thr Met Lys Met Arg
                85                  90                  95      
Gln Gln Ala Ser Phe Leu Pro Ala Thr Leu Thr Met Thr Val Asp Lys
            100                 105                 110         
Gly Asp Asn Val Asn Ile Ser Phe Lys Lys Val Leu Ile Lys Glu Glu
        115                 120                 125             
Asp Ala Val Ile Tyr Lys Asn Gly Ser Phe Ile His Ser Val Pro Arg
    130                 135                 140                 
His Glu Val Pro Asp Ile Leu Glu Val His Leu Pro His Ala Gln Pro
145                 150                 155                 160 
Gln Asp Ala Gly Val Tyr Ser Ala Arg Tyr Ile Gly Gly Asn Leu Phe
                165                 170                 175     
Thr Ser Ala Phe Thr Arg Leu Ile Val Arg Arg Cys Glu Ala Gln Lys
            180                 185                 190         
Trp Gly Pro Glu Cys Asn His Leu Cys Thr Ala Cys Met Asn Asn Gly
        195                 200                 205             
Val Cys His Glu Asp Thr Gly Glu Cys Ile Cys Pro Pro Gly Phe Met
    210                 215                 220                 
Gly Arg Thr Cys Glu Lys Ala Cys Glu Leu His Thr Phe Gly Arg Thr
225                 230                 235                 240 
Cys Lys Glu Arg Cys Ser Gly Gln Glu Gly Cys Lys Ser Tyr Val Phe
                245                 250                 255     
Cys Leu Pro Asp Pro Tyr Gly Cys Ser Cys Ala Thr Gly Trp Lys Gly
            260                 265                 270         
Leu Gln Cys Asn Glu Gly Ile Gln Arg Met Thr Pro Lys Ile Val Asp
        275                 280                 285             
Leu Pro Asp His Ile Glu Val Asn Ser Gly Lys Phe Asn Pro Ile Cys
    290                 295                 300                 
Lys Ala Ser Gly Trp Pro Leu Pro Thr Asn Glu Glu Met Thr Leu Val
305                 310                 315                 320 
Lys Pro Asp Gly Thr Val Leu His Pro Lys Asp Phe Asn His Thr Asp
                325                 330                 335     
His Phe Ser Val Ala Ile Phe Thr Ile His Arg Ile Leu Pro Pro Asp
            340                 345                 350         
Ser Gly Val Trp Val Cys Ser Val Asn Thr Val Ala Gly Met Val Glu
        355                 360                 365             
Lys Pro Phe Asn Ile Ser Val Lys Val Leu Pro Lys Pro Leu Asn Ala
    370                 375                 380                 
Pro Asn Val Ile Asp Thr Gly His Asn Phe Ala Val Ile Asn Ile Ser
385                 390                 395                 400 
Ser Glu Pro Tyr Phe Gly Asp Gly Pro Ile Lys Ser Lys Lys Leu Leu
                405                 410                 415     
Tyr Lys Pro Val Asn His Tyr Glu Ala Trp Gln His Ile Gln Val Thr
            420                 425                 430         
Asn Glu Ile Val Thr Leu Asn Tyr Leu Glu Pro Arg Thr Glu Tyr Glu
        435                 440                 445             
Leu Cys Val Gln Leu Val Arg Arg Gly Glu Gly Gly Glu Gly His Pro
    450                 455                 460                 
Gly Pro Val Arg Arg Phe Thr Thr Ala Ser Ile Gly Leu Pro Pro Pro
465                 470                 475                 480 
Arg Gly Leu Asn Leu Leu Pro Lys Ser Gln Thr Thr Leu Asn Leu Thr
                485                 490                 495     
Trp Gln Pro Ser Ser Glu Asp Asp Phe Tyr Val Glu Val Glu Arg Arg
            500                 505                 510         
Ser Val Gln Lys Ser Asp Gln Gln Asn Ile Lys Val Pro Gly Asn Leu
        515                 520                 525             
Thr Ser Val Leu Leu Asn Asn Leu His Pro Arg Glu Gln Tyr Val Val
    530                 535                 540                 
Arg Ala Arg Val Asn Thr Lys Ala Gln Gly Glu Trp Ser Glu Asp Leu
545                 550                 555                 560 
Thr Ala Trp Thr Leu Ser Asp Ile Leu Pro Pro Gln Pro Glu Asn Ile
                565                 570                 575     
Lys Ile Ser Asn Ile Thr His Ser Ser Ala Val Ile Ser Trp Thr Ile
            580                 585                 590         
Leu Asp Gly Tyr Ser Ile Ser Ser Ile Thr Ile Arg Tyr Lys Val Gln
        595                 600                 605             
Gly Lys Asn Glu Asp Gln His Val Asp Val Lys Ile Lys Asn Ala Thr
    610                 615                 620                 
Ile Thr Gln Tyr Gln Leu Lys Gly Leu Glu Pro Glu Thr Ala Tyr Gln
625                 630                 635                 640 
Val Asp Ile Phe Ala Glu Asn Asn Ile Gly Ser Ser Asn Pro Ala Phe
                645                 650                 655     
Ser His Glu Leu Val Thr Leu Pro Glu Ser Gln Ala Pro Ala Asp Leu
            660                 665                 670         
Gly Gly Gly Lys Met Leu Leu Ile Ala Ile Leu Gly Ser Ala Gly Met
        675                 680                 685             
Thr Cys Leu Thr Val Leu Leu Ala Phe Leu Ile Ile Leu Gln Leu Lys
    690                 695                 700                 
Arg Ala Asn Val Gln Arg Arg Met Ala Gln Ala Phe Gln Asn Val Arg
705                 710                 715                 720 
Glu Glu Pro Ala Val Gln Phe Asn Ser Gly Thr Leu Ala Leu Asn Arg
                725                 730                 735     
Lys Val Lys Asn Asn Pro Asp Pro Thr Ile Tyr Pro Val Leu Asp Trp
            740                 745                 750         
Asn Asp Ile Lys Phe Gln Asp Val Ile Gly Glu Gly Asn Phe Gly Gln
        755                 760                 765             
Val Leu Lys Ala Arg Ile Lys Lys Asp Gly Leu Arg Met Asp Ala Ala
    770                 775                 780                 
Ile Lys Arg Met Lys Glu Tyr Ala Ser Lys Asp Asp His Arg
785                 790                 795             

<210> 250
<211> 821
<212> PRT
<213> Homo sapiens

<220> 
<223> TEKc 34

<400> 250
Met Asp Ser Leu Ala Ser Leu Val Leu Cys Gly Val Ser Leu Leu Leu
 1               5                  10                  15      
Ser Gly Thr Val Glu Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu
            20                  25                  30          
Pro Leu Val Ser Asp Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly
        35                  40                  45              
Trp Arg Pro His Glu Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu
    50                  55                  60                  
Met Asn Gln His Gln Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg
65                  70                  75                  80  
Glu Trp Ala Lys Lys Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile
                85                  90                  95      
Asn Gly Ala Tyr Phe Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg
            100                 105                 110         
Ile Arg Thr Met Lys Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr
        115                 120                 125             
Leu Thr Met Thr Val Asp Lys Gly Asp Asn Val Asn Ile Ser Phe Lys
    130                 135                 140                 
Lys Val Leu Ile Lys Glu Glu Asp Ala Val Ile Tyr Lys Asn Gly Ser
145                 150                 155                 160 
Phe Ile His Ser Val Pro Arg His Glu Val Pro Asp Ile Leu Glu Val
                165                 170                 175     
His Leu Pro His Ala Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg
            180                 185                 190         
Tyr Ile Gly Gly Asn Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val
        195                 200                 205             
Arg Arg Cys Glu Ala Gln Lys Trp Gly Pro Glu Cys Asn His Leu Cys
    210                 215                 220                 
Thr Ala Cys Met Asn Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys
225                 230                 235                 240 
Ile Cys Pro Pro Gly Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu
                245                 250                 255     
Leu His Thr Phe Gly Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Glu
            260                 265                 270         
Gly Cys Lys Ser Tyr Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser
        275                 280                 285             
Cys Ala Thr Gly Trp Lys Gly Leu Gln Cys Asn Glu Gly Ile Gln Arg
    290                 295                 300                 
Met Thr Pro Lys Ile Val Asp Leu Pro Asp His Ile Glu Val Asn Ser
305                 310                 315                 320 
Gly Lys Phe Asn Pro Ile Cys Lys Ala Ser Gly Trp Pro Leu Pro Thr
                325                 330                 335     
Asn Glu Glu Met Thr Leu Val Lys Pro Asp Gly Thr Val Leu His Pro
            340                 345                 350         
Lys Asp Phe Asn His Thr Asp His Phe Ser Val Ala Ile Phe Thr Ile
        355                 360                 365             
His Arg Ile Leu Pro Pro Asp Ser Gly Val Trp Val Cys Ser Val Asn
    370                 375                 380                 
Thr Val Ala Gly Met Val Glu Lys Pro Phe Asn Ile Ser Val Lys Val
385                 390                 395                 400 
Leu Pro Lys Pro Leu Asn Ala Pro Asn Val Ile Asp Thr Gly His Asn
                405                 410                 415     
Phe Ala Val Ile Asn Ile Ser Ser Glu Pro Tyr Phe Gly Asp Gly Pro
            420                 425                 430         
Ile Lys Ser Lys Lys Leu Leu Tyr Lys Pro Val Asn His Tyr Glu Ala
        435                 440                 445             
Trp Gln His Ile Gln Val Thr Asn Glu Ile Val Thr Leu Asn Tyr Leu
    450                 455                 460                 
Glu Pro Arg Thr Glu Tyr Glu Leu Cys Val Gln Leu Val Arg Arg Gly
465                 470                 475                 480 
Glu Gly Gly Glu Gly His Pro Gly Pro Val Arg Arg Phe Thr Thr Ala
                485                 490                 495     
Ser Ile Gly Leu Pro Pro Pro Arg Gly Leu Asn Leu Leu Pro Lys Ser
            500                 505                 510         
Gln Thr Thr Leu Asn Leu Thr Trp Gln Pro Ser Ser Glu Asp Asp Phe
        515                 520                 525             
Tyr Val Glu Val Glu Arg Arg Ser Val Gln Lys Ser Asp Gln Gln Asn
    530                 535                 540                 
Ile Lys Val Pro Gly Asn Leu Thr Ser Val Leu Leu Asn Asn Leu His
545                 550                 555                 560 
Pro Arg Glu Gln Tyr Val Val Arg Ala Arg Val Asn Thr Lys Ala Gln
                565                 570                 575     
Gly Glu Trp Ser Glu Asp Leu Thr Ala Trp Thr Leu Ser Asp Ile Leu
            580                 585                 590         
Pro Pro Gln Pro Glu Asn Ile Lys Ile Ser Asn Ile Thr His Ser Ser
        595                 600                 605             
Ala Val Ile Ser Trp Thr Ile Leu Asp Gly Tyr Ser Ile Ser Ser Ile
    610                 615                 620                 
Thr Ile Arg Tyr Lys Val Gln Gly Lys Asn Glu Asp Gln His Val Asp
625                 630                 635                 640 
Val Lys Ile Lys Asn Ala Thr Ile Thr Gln Tyr Gln Leu Lys Gly Leu
                645                 650                 655     
Glu Pro Glu Thr Ala Tyr Gln Val Asp Ile Phe Ala Glu Asn Asn Ile
            660                 665                 670         
Gly Ser Ser Asn Pro Ala Phe Ser His Glu Leu Val Thr Leu Pro Glu
        675                 680                 685             
Ser Gln Ala Pro Ala Asp Leu Gly Gly Gly Lys Met Leu Leu Ile Ala
    690                 695                 700                 
Ile Leu Gly Ser Ala Gly Met Thr Cys Leu Thr Val Leu Leu Ala Phe
705                 710                 715                 720 
Leu Ile Ile Leu Gln Leu Lys Arg Ala Asn Val Gln Arg Arg Met Ala
                725                 730                 735     
Gln Ala Phe Gln Asn Val Arg Glu Glu Pro Ala Val Gln Phe Asn Ser
            740                 745                 750         
Gly Thr Leu Ala Leu Asn Arg Lys Val Lys Asn Asn Pro Asp Pro Thr
        755                 760                 765             
Ile Tyr Pro Val Leu Asp Trp Asn Asp Ile Lys Phe Gln Asp Val Ile
    770                 775                 780                 
Gly Glu Gly Asn Phe Gly Gln Val Leu Lys Ala Arg Ile Lys Lys Asp
785                 790                 795                 800 
Gly Leu Arg Met Asp Ala Ala Ile Lys Arg Met Lys Glu Tyr Ala Ser
                805                 810                 815     
Lys Asp Asp His Arg
            820     

<210> 251
<211> 786
<212> PRT
<213> Homo sapiens

<220> 
<223> TIE isoform

<400> 251
Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala
 1               5                  10                  15      
Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg
            20                  25                  30          
Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala
        35                  40                  45              
Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu
    50                  55                  60                  
Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu
65                  70                  75                  80  
Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro
                85                  90                  95      
Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg
            100                 105                 110         
Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu
        115                 120                 125             
Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Ala Val Leu
    130                 135                 140                 
Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser
145                 150                 155                 160 
Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly
                165                 170                 175     
Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile
            180                 185                 190         
Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly Ser Ala Phe Phe
        195                 200                 205             
Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp Gly Pro Gly Cys
    210                 215                 220                 
Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val Cys His Asp His
225                 230                 235                 240 
Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly Thr Arg Cys Glu
                245                 250                 255     
Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys Gln Glu Gln Cys
            260                 265                 270         
Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys Leu Pro Asp Pro
        275                 280                 285             
Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser Gln Cys Gln Glu
    290                 295                 300                 
Ala Cys Ala Pro Gly His Phe Gly Ala Asp Cys Arg Leu Gln Cys Gln
305                 310                 315                 320 
Cys Gln Asn Gly Gly Thr Cys Asp Arg Phe Ser Gly Cys Val Cys Pro
                325                 330                 335     
Ser Gly Trp His Gly Val His Cys Glu Lys Ser Asp Arg Ile Pro Gln
            340                 345                 350         
Ile Leu Asn Met Ala Ser Glu Leu Glu Phe Asn Leu Glu Thr Met Pro
        355                 360                 365             
Arg Ile Asn Cys Ala Ala Ala Gly Asn Pro Phe Pro Val Arg Gly Ser
    370                 375                 380                 
Ile Glu Leu Arg Lys Pro Asp Gly Thr Val Leu Leu Ser Thr Lys Ala
385                 390                 395                 400 
Ile Val Glu Pro Glu Lys Thr Thr Ala Glu Phe Glu Val Pro Arg Leu
                405                 410                 415     
Val Leu Ala Asp Ser Gly Phe Trp Glu Cys Arg Val Ser Thr Ser Gly
            420                 425                 430         
Gly Gln Asp Ser Arg Arg Phe Lys Val Asn Val Lys Val Pro Pro Val
        435                 440                 445             
Pro Leu Ala Ala Pro Arg Leu Leu Thr Lys Gln Ser Arg Gln Leu Val
    450                 455                 460                 
Val Ser Pro Leu Val Ser Phe Ser Gly Asp Gly Pro Ile Ser Thr Val
465                 470                 475                 480 
Arg Leu His Tyr Arg Pro Gln Asp Ser Thr Met Asp Trp Ser Thr Ile
                485                 490                 495     
Val Val Asp Pro Ser Glu Asn Val Thr Leu Met Asn Leu Arg Pro Lys
            500                 505                 510         
Thr Gly Tyr Ser Val Arg Val Gln Leu Ser Arg Pro Gly Glu Gly Gly
        515                 520                 525             
Glu Gly Ala Trp Gly Pro Pro Thr Leu Met Thr Thr Asp Cys Pro Glu
    530                 535                 540                 
Pro Leu Leu Gln Pro Trp Leu Glu Gly Trp His Val Glu Gly Thr Asp
545                 550                 555                 560 
Arg Leu Arg Val Ser Trp Ser Leu Pro Leu Val Pro Gly Pro Leu Val
                565                 570                 575     
Gly Asp Gly Phe Leu Leu Arg Leu Trp Asp Gly Thr Arg Gly Gln Glu
            580                 585                 590         
Arg Arg Glu Asn Val Ser Ser Pro Gln Ala Arg Thr Ala Leu Leu Thr
        595                 600                 605             
Gly Leu Thr Pro Gly Thr His Tyr Gln Leu Asp Val Gln Leu Tyr His
    610                 615                 620                 
Cys Thr Leu Leu Gly Pro Ala Ser Pro Pro Ala His Val Leu Leu Pro
625                 630                 635                 640 
Pro Ser Gly Pro Pro Ala Pro Arg His Leu His Ala Gln Ala Leu Ser
                645                 650                 655     
Asp Ser Glu Ile Gln Leu Thr Trp Lys His Pro Glu Ala Leu Pro Gly
            660                 665                 670         
Pro Ile Ser Lys Tyr Val Val Glu Val Gln Val Ala Gly Gly Ala Gly
        675                 680                 685             
Asp Pro Leu Trp Ile Asp Val Asp Arg Pro Glu Glu Thr Ser Thr Ile
    690                 695                 700                 
Ile Arg Gly Leu Asn Ala Ser Thr Arg Tyr Leu Phe Arg Met Arg Ala
705                 710                 715                 720 
Ser Ile Gln Gly Leu Gly Asp Trp Ser Asn Thr Val Glu Glu Ser Thr
                725                 730                 735     
Leu Gly Asn Gly Leu Gln Ala Glu Gly Pro Val Gln Glu Ser Arg Ala
            740                 745                 750         
Ala Glu Glu Gly Leu Asp Gln Gln Leu Ile Leu Ala Val Val Gly Ser
        755                 760                 765             
Val Ser Ala Thr Cys Leu Thr Ile Leu Ala Ala Leu Leu Thr Leu Val
    770                 775                 780                 
Cys Ile
785     

<210> 252
<211> 934
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (17)...(772)
<223> SR006A04

<400> 252
ggtcggcctc tggagt atg gtc tgg cgg gtg ccc cct ttc ttg ctc ccc atc 52
                  Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile
                   1               5                   10
 
ctc ttc ttg gct tct cat gtg ggc gcg gcg gtg gac ctg acg ctg ctg   100
Leu Phe Leu Ala Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu
         15                  20                  25
 
gcc aac ctg cgg ctc acg gac ccc cag cgc ttc ttc ctg act tgc gtg   148
Ala Asn Leu Arg Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val
     30                  35                  40
 
tct ggg gag gcc ggg gcg ggg agg ggc tcg gac gcc tgg ggc ccg ccc   196
Ser Gly Glu Ala Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro
 45                  50                  55                  60
 
ctg ctg ctg gag aag gac gac cgt atc gtg cgc acc ccg ccc ggg cca   244
Leu Leu Leu Glu Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro
                 65                  70                  75
 
ccc ctg cgc ctg gcg cgc aac ggt tcg cac cag gtc acg ctt cgc ggc   292
Pro Leu Arg Leu Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly
             80                  85                  90
 
ttc tcc aag ccc tcg gac ctc gtg ggc gtc ttc tcc tgc gtg ggc ggt   340
Phe Ser Lys Pro Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly
         95                 100                 105
 
gct ggg gcg cgg cgc acg cgc gtc atc tac gtg cac aac agc cct gga   388
Ala Gly Ala Arg Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly
    110                 115                 120
 
gcc cac ctg ctt cca gac aag gtc aca cac act gtg aac aaa ggt gac   436
Ala His Leu Leu Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp
125                 130                 135                 140
 
acc gct gta ctt tct gca cgt gtg cac aag gag aag cag aca gac gtg   484
Thr Ala Val Leu Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val
                145                 150                 155
 
atc tgg aag agc aac gga tcc tac ttc tac acc ctg gac tgg cat gaa   532
Ile Trp Lys Ser Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu
            160                 165                 170
 
gcc cag gat ggg cgg ttc ctg ctg cag ctc cca aat gtg cag cca cca   580
Ala Gln Asp Gly Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro
        175                 180                 185
 
tcg agc ggc atc tac agt gcc act tac ctg gaa gcc agc ccc ctg ggc   628
Ser Ser Gly Ile Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly
    190                 195                 200
 
agc gcc ttc ttt cgg ctc atc gtg cgg ggt cag agg cag agg gca gag   676
Ser Ala Phe Phe Arg Leu Ile Val Arg Gly Gln Arg Gln Arg Ala Glu
205                 210                 215                 220
 
gtt gtg ggt agg gtg gga ggc tgg gag ccc tat ggg tac ttc ctg tgg   724
Val Val Gly Arg Val Gly Gly Trp Glu Pro Tyr Gly Tyr Phe Leu Trp
                225                 230                 235
 
gtc ccc tgg agc ccc tgg atc tcc agt cct cag tgg tca ggt ggg tga   772
Val Pro Trp Ser Pro Trp Ile Ser Ser Pro Gln Trp Ser Gly Gly  *
            240                 245                 250
 
gggtcagctg ctgaagacac cttcctccag gttgtggggc tgggcgctgg gggccaggct 832
gtaccaagga gtgcccaggt tgcctacatg gaggtgtctg ccacgaccat gacggcgaat 892
gtgtatgccc ccctggcttc actggcaccc gctgtgaaca gg                    934

<210> 253
<211> 251
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR006A04

<400> 253
Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala
 1               5                  10                  15      
Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg
            20                  25                  30          
Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala
        35                  40                  45              
Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu
    50                  55                  60                  
Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu
65                  70                  75                  80  
Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro
                85                  90                  95      
Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg
            100                 105                 110         
Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu
        115                 120                 125             
Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Ala Val Leu
    130                 135                 140                 
Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser
145                 150                 155                 160 
Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly
                165                 170                 175     
Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile
            180                 185                 190         
Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly Ser Ala Phe Phe
        195                 200                 205             
Arg Leu Ile Val Arg Gly Gln Arg Gln Arg Ala Glu Val Val Gly Arg
    210                 215                 220                 
Val Gly Gly Trp Glu Pro Tyr Gly Tyr Phe Leu Trp Val Pro Trp Ser
225                 230                 235                 240 
Pro Trp Ile Ser Ser Pro Gln Trp Ser Gly Gly
                245                 250     

<210> 254
<211> 1619
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (14)...(1153)
<223> SR006B07

<400> 254
cggcctctgg agt atg gtc tgg cgg gtg ccc cct ttc ttg ctc ccc atc    49
               Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile
                1               5                   10
 
ctc ttc ttg gct tct cat gtg ggc gcg gcg gtg gac ctg acg ctg ctg   97
Leu Phe Leu Ala Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu
         15                  20                  25
 
gcc aac ctg cgg ctc acg gac ccc cag cgc ttc ttc ctg act tgc gtg   145
Ala Asn Leu Arg Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val
     30                  35                  40
 
tct ggg gag gcc ggg gcg ggg agg ggc tcg gac gcc tgg ggc ccg ccc   193
Ser Gly Glu Ala Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro
 45                  50                  55                  60
 
ctg ctg ctg gag aag gac gac cgt atc gtg cgc acc ccg ccc ggg cca   241
Leu Leu Leu Glu Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro
                 65                  70                  75
 
ccc ctg cgc ctg gcg cgc aac ggt tcg cac cag gtc acg ctt cgc ggc   289
Pro Leu Arg Leu Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly
             80                  85                  90
 
ttc tcc aag ccc tcg gac ctc gtg ggc gtc ttc tcc tgc gtg ggc ggt   337
Phe Ser Lys Pro Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly
         95                 100                 105
 
gct ggg gcg cgg cgc acg cgc gtc atc tac gtg cac aac agc cct gga   385
Ala Gly Ala Arg Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly
    110                 115                 120
 
gcc cac ctg ctt cca gac aag gtc aca cac act gtg aac aaa ggt gac   433
Ala His Leu Leu Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp
125                 130                 135                 140
 
acc gct gta ctt tct gca cgt gtg cac aag gag aag cag aca gac gtg   481
Thr Ala Val Leu Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val
                145                 150                 155
 
atc tgg aag agc aac gga tcc tac ttc tac acc ctg gac tgg cat gaa   529
Ile Trp Lys Ser Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu
            160                 165                 170
 
gcc cag gat ggg cgg ttc ctg ctg cag ctc cca aat gtg cag cca cca   577
Ala Gln Asp Gly Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro
        175                 180                 185
 
tcg agc ggc atc tac agt gcc act tac ctg gaa gcc agc ccc ctg ggc   625
Ser Ser Gly Ile Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly
    190                 195                 200
 
agc gcc ttc ttt cgg ctc atc gtg cgg ggt tgt ggg gct ggg cgc tgg   673
Ser Ala Phe Phe Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp
205                 210                 215                 220
 
ggg cca ggc tgt acc aag gag tgc cca ggt tgc cta cat gga ggt gtc   721
Gly Pro Gly Cys Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val
                225                 230                 235
 
tgc cac gac cat gac ggc gaa tgt gta tgc ccc cct ggc ttc act ggc   769
Cys His Asp His Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly
            240                 245                 250
 
acc cgc tgt gaa cag gcc tgc aga gag ggc cgt ttt ggg cag agc tgc   817
Thr Arg Cys Glu Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys
        255                 260                 265
 
cag gag cag tgc cca ggc ata tca ggc tgc cgg ggc ctc acc ttc tgc   865
Gln Glu Gln Cys Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys
    270                 275                 280
 
ctc cca gac ccc tat ggc tgc tct tgt gga tct ggc tgg aga gga agc   913
Leu Pro Asp Pro Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser
285                 290                 295                 300
 
cag tgc caa gaa gct tgt gcc cct ggt cat ttt ggg gct gat tgc cga   961
Gln Cys Gln Glu Ala Cys Ala Pro Gly His Phe Gly Ala Asp Cys Arg
                305                 310                 315
 
ctc cag tgc cag tgt cag aat ggt ggc act tgt gac cgg ttc agt ggt   1009
Leu Gln Cys Gln Cys Gln Asn Gly Gly Thr Cys Asp Arg Phe Ser Gly
            320                 325                 330
 
tgt gtc tgc ccc tct ggg tgg cat gga gtg cac tgt gag aag tca ggc   1057
Cys Val Cys Pro Ser Gly Trp His Gly Val His Cys Glu Lys Ser Gly
        335                 340                 345
 
tgg agg gac tgg gta gat acc tcc act gag aaa cag aac acg gat gag   1105
Trp Arg Asp Trp Val Asp Thr Ser Thr Glu Lys Gln Asn Thr Asp Glu
    350                 355                 360
 
ggg cgc ttt ggt ggt cac gtg tct gcc cct gtg gga gct cca gga tga   1153
Gly Arg Phe Gly Gly His Val Ser Ala Pro Val Gly Ala Pro Gly  *
365                 370                 375
 
gtgtcctttc tccccagacc ggatccccca gatcctcaac atggcctcag aactggagtt 1213
caacttagag acgatgcccc ggatcaactg tgcagctgca gggaacccct tccccgtgcg 1273
gggcagcata gagctacgca agccagacgg cactgtgctc ctgtccacca aggccattgt 1333
ggagccagag aagaccacag ctgagttcga ggtgccccgc ttggttcttg cggacagtgg 1393
gttctgggag tgccgtgtgt ccacatctgg cggccaagac agccggcgct tcaaggtcaa 1453
tgtgaaagtg ccccccgtgc ccctggctgc acctcggctc ctgaccaagc agagccgcca 1513
gcttgtggtc tccccgctgg tctcgttctc tggggatgga cccatctcca ctgtccgcct 1573
gcactaccgg ccccaggaca gtaccatgga ctggtcgacc attgtg                1619

<210> 255
<211> 379
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR006B07

<400> 255
Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala
 1               5                  10                  15      
Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg
            20                  25                  30          
Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala
        35                  40                  45              
Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu
    50                  55                  60                  
Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu
65                  70                  75                  80  
Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro
                85                  90                  95      
Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg
            100                 105                 110         
Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu
        115                 120                 125             
Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Ala Val Leu
    130                 135                 140                 
Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser
145                 150                 155                 160 
Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly
                165                 170                 175     
Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile
            180                 185                 190         
Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly Ser Ala Phe Phe
        195                 200                 205             
Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp Gly Pro Gly Cys
    210                 215                 220                 
Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val Cys His Asp His
225                 230                 235                 240 
Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly Thr Arg Cys Glu
                245                 250                 255     
Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys Gln Glu Gln Cys
            260                 265                 270         
Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys Leu Pro Asp Pro
        275                 280                 285             
Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser Gln Cys Gln Glu
    290                 295                 300                 
Ala Cys Ala Pro Gly His Phe Gly Ala Asp Cys Arg Leu Gln Cys Gln
305                 310                 315                 320 
Cys Gln Asn Gly Gly Thr Cys Asp Arg Phe Ser Gly Cys Val Cys Pro
                325                 330                 335     
Ser Gly Trp His Gly Val His Cys Glu Lys Ser Gly Trp Arg Asp Trp
            340                 345                 350         
Val Asp Thr Ser Thr Glu Lys Gln Asn Thr Asp Glu Gly Arg Phe Gly
        355                 360                 365             
Gly His Val Ser Ala Pro Val Gly Ala Pro Gly
    370                 375                 


<210> 256
<211> 740
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (34)...(519)
<223> SR006B06

<400> 256
tcgtcctggc tggcctgggt cggcctctgg agt atg gtc tgg cgg gtg ccc cct  54
                                     Met Val Trp Arg Val Pro Pro
                                      1               5
 
ttc ttg ctc ccc atc ctc ttc ttg gct tct cat gtg ggc gcg gcg gtg   102
Phe Leu Leu Pro Ile Leu Phe Leu Ala Ser His Val Gly Ala Ala Val
         10                  15                  20
 
gac ctg acg ctg ctg gcc aac ctg cgg ctc acg gac ccc cag cgc ttc   150
Asp Leu Thr Leu Leu Ala Asn Leu Arg Leu Thr Asp Pro Gln Arg Phe
     25                  30                  35
 
ttc ctg act tgc gtg tct ggg gag gcc ggg gcg ggg agg ggc tcg gac   198
Phe Leu Thr Cys Val Ser Gly Glu Ala Gly Ala Gly Arg Gly Ser Asp
 40                  45                  50                  55
 
gcc tgg ggc ccg ccc ctg ctg ctg gag aag gac gac cgt atc gtg cgc   246
Ala Trp Gly Pro Pro Leu Leu Leu Glu Lys Asp Asp Arg Ile Val Arg
                 60                  65                  70
 
acc ccg ccc ggg cca ccc ctg cgc ctg gcg cgc aac ggt tcg cac cag   294
Thr Pro Pro Gly Pro Pro Leu Arg Leu Ala Arg Asn Gly Ser His Gln
             75                  80                  85
 
gtc acg ctt cgc ggc ttc tcc aag ccc tcg gac ctc gtg ggc gtc ttc   342
Val Thr Leu Arg Gly Phe Ser Lys Pro Ser Asp Leu Val Gly Val Phe
         90                  95                 100
 
tcc tgc gtg ggc ggt gct ggg gcg cgg cgc acg cgc gtc atc tac gtg   390
Ser Cys Val Gly Gly Ala Gly Ala Arg Arg Thr Arg Val Ile Tyr Val
    105                 110                 115
 
cac aac agc cct gga ggt gag tta ggc agg cgg ggg gat ggc gcg ggg   438
His Asn Ser Pro Gly Gly Glu Leu Gly Arg Arg Gly Asp Gly Ala Gly
120                 125                 130                 135
 
aaa acc agg ccg ctg acc cac ctt cca ccc cgc agc cca cct gct tcc   486
Lys Thr Arg Pro Leu Thr His Leu Pro Pro Arg Ser Pro Pro Ala Ser
                140                 145                 150
 
aga caa ggt cac aca cac tgt gaa caa agg tga caccgctgta ctttctgcac 539
Arg Gln Gly His Thr His Cys Glu Gln Arg  *
            155                 160
 
gtgtgcacaa ggagaagcag acagacgtga tctggaagag caacggatcc tacttctaca 599
ccctggactg gcatgaagcc caggatgggc ggttcctgct gcagctccca aatgtgcagc 659
caccatcgag cggcatctac agtgccactt acctggaagc cagccccctg ggcagcgcct 719
tctttcggct catcgtgcgg g                                           740

<210> 257
<211> 161
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR006B06

<400> 257
Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala
 1               5                  10                  15      
Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg
            20                  25                  30          
Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala
        35                  40                  45              
Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu
    50                  55                  60                  
Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu
65                  70                  75                  80  
Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro
                85                  90                  95      
Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg
            100                 105                 110         
Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Gly Glu Leu Gly
        115                 120                 125             
Arg Arg Gly Asp Gly Ala Gly Lys Thr Arg Pro Leu Thr His Leu Pro
    130                 135                 140                 
Pro Arg Ser Pro Pro Ala Ser Arg Gln Gly His Thr His Cys Glu Gln
145                 150                 155                 160 
Arg
    


<210> 258
<211> 1761
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (14)...(1258)
<223> SR006B12

<400> 258
cggcctctgg agt atg gtc tgg cgg gtg ccc cct ttc ttg ctc ccc atc    49
               Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile
                1               5                   10
 
ctc ttc ttg gct tct cat gtg ggc gcg gcg gtg gac ctg acg ctg ctg   97
Leu Phe Leu Ala Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu
         15                  20                  25
 
gcc aac ctg cgg ctc acg gac ccc cag cgc ttc ttc ctg act tgc gtg   145
Ala Asn Leu Arg Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val
     30                  35                  40
 
tct ggg gag gcc ggg gcg ggg agg ggc tcg gac gcc tgg ggc ccg ccc   193
Ser Gly Glu Ala Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro
 45                  50                  55                  60
 
ctg ctg ctg gag aag gac gac cgt atc gtg cgc acc ccg ccc ggg cca   241
Leu Leu Leu Glu Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro
                 65                  70                  75
 
ccc ctg cgc ctg gcg cgc aac ggt tcg cac cag gtc acg ctt cgc ggc   289
Pro Leu Arg Leu Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly
             80                  85                  90
 
ttc tcc aag ccc tcg gac ctc gtg ggc gtc ttc tcc tgc gtg ggc ggt   337
Phe Ser Lys Pro Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly
         95                 100                 105
 
gct ggg gcg cgg cgc acg cgc gtc atc tac gtg cac aac agc cct gga   385
Ala Gly Ala Arg Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly
    110                 115                 120
 
gcc cac ctg ctt cca gac aag gtc aca cac act gtg aac aaa ggt gac   433
Ala His Leu Leu Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp
125                 130                 135                 140
 
acc gct gta ctt tct gca cgt gtg cac aag gag aag cag aca gac gtg   481
Thr Ala Val Leu Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val
                145                 150                 155
 
atc tgg aag agc aac gga tcc tac ttc tac acc ctg gac tgg cat gaa   529
Ile Trp Lys Ser Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu
            160                 165                 170
 
gcc cag gat ggg cgg ttc ctg ctg cag ctc cca aat gtg cag cca cca   577
Ala Gln Asp Gly Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro
        175                 180                 185
 
tcg agc ggc atc tac agt gcc act tac ctg gaa gcc agc ccc ctg ggc   625
Ser Ser Gly Ile Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly
    190                 195                 200
 
agc gcc ttc ttt cgg ctc atc gtg cgg ggt tgt ggg gct ggg cgc tgg   673
Ser Ala Phe Phe Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp
205                 210                 215                 220
 
ggg cca ggc tgt acc aag gag tgc cca ggt tgc cta cat gga ggt gtc   721
Gly Pro Gly Cys Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val
                225                 230                 235
 
tgc cac gac cat gac ggc gaa tgt gta tgc ccc cct ggc ttc act ggc   769
Cys His Asp His Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly
            240                 245                 250
 
acc cgc tgt gaa cag gcc tgc aga gag ggc cgt ttt ggg cag agc tgc   817
Thr Arg Cys Glu Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys
        255                 260                 265
 
cag gag cag tgc cca ggc ata tca ggc tgc cgg ggc ctc acc ttc tgc   865
Gln Glu Gln Cys Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys
    270                 275                 280
 
ctc cca gac ccc tat ggc tgc tct tgt gga tct ggc tgg aga gga agc   913
Leu Pro Asp Pro Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser
285                 290                 295                 300
 
cag tgc caa gaa gct tgt gcc cct ggt cat ttt ggg gct gat tgc cga   961
Gln Cys Gln Glu Ala Cys Ala Pro Gly His Phe Gly Ala Asp Cys Arg
                305                 310                 315
 
ctc cag tgc cag tgt cag aat ggt ggc act tgt gac cgg ttc agt ggt   1009
Leu Gln Cys Gln Cys Gln Asn Gly Gly Thr Cys Asp Arg Phe Ser Gly
            320                 325                 330
 
tgt gtc tgc ccc tct ggg tgg cat gga gtg cac tgt gag aag tca gac   1057
Cys Val Cys Pro Ser Gly Trp His Gly Val His Cys Glu Lys Ser Asp
        335                 340                 345
 
cgg atc ccc cag atc ctc aac atg gcc tca gaa ctg gag ttc aac tta   1105
Arg Ile Pro Gln Ile Leu Asn Met Ala Ser Glu Leu Glu Phe Asn Leu
    350                 355                 360
 
gag acg atg ccc cgg atc aac tgt gca gct gca ggg aac ccc ttc ccc   1153
Glu Thr Met Pro Arg Ile Asn Cys Ala Ala Ala Gly Asn Pro Phe Pro
365                 370                 375                 380
 
gtg cgg ggc agc ata gag cta cgc aag cca gac ggc act gtg ctc ctg   1201
Val Arg Gly Ser Ile Glu Leu Arg Lys Pro Asp Gly Thr Val Leu Leu
                385                 390                 395
 
gtc agc ccc caa tca ccc caa ccc acc agc ccc tca ggc cgc ctg ctt   1249
Val Ser Pro Gln Ser Pro Gln Pro Thr Ser Pro Ser Gly Arg Leu Leu
            400                 405                 410
 
cac agc tga tccctaagac cccctagtcc ctcagaactt tctgcagggc           1298
His Ser  *

 
ccacccattg gcctgaccat tgctcacatg aggtcaggct gattggtgag ggggctgcca 1358
ctgggcctct gtcctgccat cagtccagac ggacacctgg gtgcctgcca cagaggtgcc 1418
cgttccctgt gacctgtccc cttcccccat ctcttttagt ccaccaaggc cattgtggag 1478
ccagagaaga ccacagctga gttcgaggtg ccccgcttgg ttcttgcgga cagtgggttc 1538
tgggagtgcc gtgtgtccac atctggcggc caagacagcc ggcgcttcaa ggtcaatgtg 1598
aaagtgcccc ccgtgcccct ggctgcacct cggctcctga ccaagcagag ccgccagctt 1658
gtggtctccc cgctggtctc gttctctggg gatggaccca tctccactgt ccgcctgcac 1718
taccggcccc aggacagtac catggactgg tcgaccattg tgg                   1761

<210> 259
<211> 414
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR006B12

<400> 259
Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala
 1               5                  10                  15      
Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg
            20                  25                  30          
Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala
        35                  40                  45              
Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu
    50                  55                  60                  
Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu
65                  70                  75                  80  
Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro
                85                  90                  95      
Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg
            100                 105                 110         
Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu
        115                 120                 125             
Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Ala Val Leu
    130                 135                 140                 
Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser
145                 150                 155                 160 
Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly
                165                 170                 175     
Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile
            180                 185                 190         
Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly Ser Ala Phe Phe
        195                 200                 205             
Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp Gly Pro Gly Cys
    210                 215                 220                 
Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val Cys His Asp His
225                 230                 235                 240 
Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly Thr Arg Cys Glu
                245                 250                 255     
Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys Gln Glu Gln Cys
            260                 265                 270         
Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys Leu Pro Asp Pro
        275                 280                 285             
Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser Gln Cys Gln Glu
    290                 295                 300                 
Ala Cys Ala Pro Gly His Phe Gly Ala Asp Cys Arg Leu Gln Cys Gln
305                 310                 315                 320 
Cys Gln Asn Gly Gly Thr Cys Asp Arg Phe Ser Gly Cys Val Cys Pro
                325                 330                 335     
Ser Gly Trp His Gly Val His Cys Glu Lys Ser Asp Arg Ile Pro Gln
            340                 345                 350         
Ile Leu Asn Met Ala Ser Glu Leu Glu Phe Asn Leu Glu Thr Met Pro
        355                 360                 365             
Arg Ile Asn Cys Ala Ala Ala Gly Asn Pro Phe Pro Val Arg Gly Ser
    370                 375                 380                 
Ile Glu Leu Arg Lys Pro Asp Gly Thr Val Leu Leu Val Ser Pro Gln
385                 390                 395                 400 
Ser Pro Gln Pro Thr Ser Pro Ser Gly Arg Leu Leu His Ser
                405                 410                 


<210> 260
<211> 1230
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (14)...(967)
<223> SR006B10

<400> 260
cggcctctgg agt atg gtc tgg cgg gtg ccc cct ttc ttg ctc ccc atc    49
               Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile
                1               5                   10
 
ctc ttc ttg gct tct cat gtg ggc gcg gcg gtg gac ctg acg ctg ctg   97
Leu Phe Leu Ala Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu
         15                  20                  25
 
gcc aac ctg cgg ctc acg gac ccc cag cgc ttc ttc ctg act tgc gtg   145
Ala Asn Leu Arg Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val
     30                  35                  40
 
tct ggg gag gcc ggg gcg ggg agg ggc tcg gac gcc tgg ggc ccg ccc   193
Ser Gly Glu Ala Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro
 45                  50                  55                  60
 
ctg ctg ctg gag aag gac gac cgt atc gtg cgc acc ccg ccc ggg cca   241
Leu Leu Leu Glu Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro
                 65                  70                  75
 
ccc ctg cgc ctg gcg cgc aac ggt tcg cac cag gtc acg ctt cgc ggc   289
Pro Leu Arg Leu Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly
             80                  85                  90
 
ttc tcc aag ccc tcg gac ctc gtg ggc gtc ttc tcc tgc gtg ggc ggt   337
Phe Ser Lys Pro Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly
         95                 100                 105
 
gct ggg gcg cgg cgc acg cgc gtc atc tac gtg cac aac agc cct gga   385
Ala Gly Ala Arg Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly
    110                 115                 120
 
gcc cac ctg ctt cca gac aag gtc aca cac act gtg aac aaa ggt gac   433
Ala His Leu Leu Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp
125                 130                 135                 140
 
acc gct gta ctt tct gca cgt gtg cac aag gag aag cag aca gac gtg   481
Thr Ala Val Leu Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val
                145                 150                 155
 
atc tgg aag agc aac gga tcc tac ttc tac acc ctg gac tgg cat gaa   529
Ile Trp Lys Ser Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu
            160                 165                 170
 
gcc cag gat ggg cgg ttc ctg ctg cag ctc cca aat gtg cag cca cca   577
Ala Gln Asp Gly Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro
        175                 180                 185
 
tcg agc ggc atc tac agt gcc act tac ctg gaa gcc agc ccc ctg ggc   625
Ser Ser Gly Ile Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly
    190                 195                 200
 
agc gcc ttc ttt cgg ctc atc gtg cgg ggt tgt ggg gct ggg cgc tgg   673
Ser Ala Phe Phe Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp
205                 210                 215                 220
 
ggg cca ggc tgt acc aag gag tgc cca ggt tgc cta cat gga ggt gtc   721
Gly Pro Gly Cys Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val
                225                 230                 235
 
tgc cac gac cat gac ggc gaa tgt gta tgc ccc cct ggc ttc act ggc   769
Cys His Asp His Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly
            240                 245                 250
 
acc cgc tgt gaa cag gcc tgc aga gag ggc cgt ttt ggg cag agc tgc   817
Thr Arg Cys Glu Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys
        255                 260                 265
 
cag gag cag tgc cca ggc ata tca ggc tgc cgg ggc ctc acc ttc tgc   865
Gln Glu Gln Cys Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys
    270                 275                 280
 
ctc cca gac ccc tat ggc tgc tct tgt gga tct ggc tgg aga gga agc   913
Leu Pro Asp Pro Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser
285                 290                 295                 300
 
cag tgc caa gaa gtc cac caa ggc cat tgt gga gcc aga gaa gac cac   961
Gln Cys Gln Glu Val His Gln Gly His Cys Gly Ala Arg Glu Asp His
                305                 310                 315
 
agc tga gttcgaggtg ccccgcttgg ttcttgcgga cagtgggttc tgggagtgcc    1017
Ser  *

 
gtgtgtccac atctggcggc caagacagcc ggcgcttcaa ggtcaatgtg aaagtgcccc 1077
ccgtgcccct ggctgcacct cggctcctga ccaagcagag ccgccagctt gtggtctccc 1137
cgctggtctc gttctctggg gatggaccca tctccactgt ccgcctgcac taccggcccc 1197
aggacagtac catggactgg tcgaccattg tgg                              1230

<210> 261
<211> 317
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR006B10

<400> 261
Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala
 1               5                  10                  15      
Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg
            20                  25                  30          
Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala
        35                  40                  45              
Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu
    50                  55                  60                  
Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu
65                  70                  75                  80  
Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro
                85                  90                  95      
Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg
            100                 105                 110         
Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu
        115                 120                 125             
Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Ala Val Leu
    130                 135                 140                 
Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser
145                 150                 155                 160 
Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly
                165                 170                 175     
Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile
            180                 185                 190         
Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly Ser Ala Phe Phe
        195                 200                 205             
Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp Gly Pro Gly Cys
    210                 215                 220                 
Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val Cys His Asp His
225                 230                 235                 240 
Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly Thr Arg Cys Glu
                245                 250                 255     
Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys Gln Glu Gln Cys
            260                 265                 270         
Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys Leu Pro Asp Pro
        275                 280                 285             
Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser Gln Cys Gln Glu
    290                 295                 300                 
Val His Gln Gly His Cys Gly Ala Arg Glu Asp His Ser
305                 310                 315         

<210> 262
<211> 2273
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR016G03

<400> 262
ctctggagta tggtctggcg ggtgccccct ttcttgctcc ccatcctctt cttggcttct 60
catgtgggcg cggcggtgga cctgacgctg ctggccaacc tgcggctcac ggacccccag 120
cgcttcttcc tgacttgcgt gtctggggag gccggggcgg ggaggggctc ggacgcctgg 180
ggcccgcccc tgctgctgga gaaggacgac cgtatcgtgc gcaccccgcc cgggccaccc 240
ctgcgcctgg cgcgcaacgg ttcgcaccag gtcacgcttc gcggcttctc caagccctcg 300
gacctcgtgg gcgtcttctc ctgcgtgggc ggtgctgggg cgcggcgcac gcgcgtcatc 360
tacgtgcaca acagccctgg agcccacctg cttccagaca aggtcacaca cactgtgaac 420
aaaggtgaca ccgctgtact ttctgcacgt gtgcacaagg agaagcagac agacgtgatc 480
tggaagagca acggatccta cttctacacc ctggactggc atgaagccca ggatgggcgg 540
ttcctgctgc agctcccaaa tgtgcagcca ccatcgagcg gcatctacag tgccacttac 600
ctggaagcca gccccctggg cagcgccttc tttcggctca tcgtgcgggg ttgtggggct 660
gggcgctggg ggccaggctg taccaaggag tgcccaggtt gcctacatgg aggtgtctgc 720
cacgaccatg acggcgaatg tgtatgcccc cctggcttca ctggcacccg ctgtgaacag 780
gcctgcagag agggccgttt tgggcagagc tgccaggagc agtgcccagg catatcaggc 840
tgccggggcc tcaccttctg cctcccagac ccctatggct gctcttgtgg atctggctgg 900
agaggaagcc agtgccaaga agcttgtgcc cctggtcatt ttggggctga ttgccgactc 960
cagtgccagt gtcagaatgg tggcacttgt gaccggttca gtggttgtgt ctgcccctct 1020
gggtggcatg gagtgcactg tgagaagtca gaccggatcc cccagatcct caacatggcc 1080
tcagaactgg agttcaactt agagacgatg ccccggatca actgtgcagc tgcagggaac 1140
cccttccccg tgcggggcag catagagcta cgcaagccag acggcactgt gctcctgtcc 1200
accaaggcca ttgtggagcc agagaagacc acagctgagt tcgaggtgcc ccgcttggtt 1260
cttgcggaca gtgggttctg ggagtgccgt gtgtccacat ctggcggcca agacagccgg 1320
cgcttcaagg tcaatgtgaa agtgcccccc gtgcccctgg ctgcacctcg gctcctgacc 1380
aagcagagcc gccagcttgt ggtctccccg ctggtctcgt tctctgggga tggacccatc 1440
tccactgtcc gcctgcacta ccggccccag gacagtacca tggactggtc gaccattgtg 1500
gtggacccca gtgagaacgt gacgttaatg aacctgaggc caaagacagg atacagtgtt 1560
cgtgtgcagc tgagccggcc aggggaagga ggagaggggg cctgggggcc tcccaccctc 1620
atgaccacag actgtcctga gcctttgttg cagccgtggt tggagggctg gcatgtggaa 1680
ggcactgacc ggctgcgagt gagctggtcc ttgcccttgg tgcccgggcc actggtgggc 1740
gacggtttcc tgctgcgcct gtgggacggg acacgggggc aggagcggcg ggagaacgtc 1800
tcatcccccc aggcccgcac tgccctcctg acgggactca cgcctggcac ccactaccag 1860
ctggatgtgc agctctacca ctgcaccctc ctgggcccgg cctcgccccc tgcacacgtg 1920
cttctgcccc ccagtgggcc tccagccccc cgacacctcc acgcccaggc cctctcagac 1980
tccgagatcc agctgacatg gaagcacccg gaggctctgc ctgggccaat atccaagtac 2040
gttgtggagg tgcaggtggc tgggggtgca ggagacccac tgtggataga cgtggacagg 2100
cctgaggaga caagcaccat catccgtggc ctcaacgcca gcacgcgcta cctcttccgc 2160
atgcgggcca gcattcaggg gctcggggac tggagcaaca cagtagaaga gtccaccctg 2220
ggcaacggtg agagggcagg gcccacagga ccccccgggc tctgagcggg gag        2273

<210> 263
<211> 751
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR016G03

<400> 263
Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala
 1               5                  10                  15      
Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg
            20                  25                  30          
Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala
        35                  40                  45              
Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu
    50                  55                  60                  
Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu
65                  70                  75                  80  
Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro
                85                  90                  95      
Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg
            100                 105                 110         
Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu
        115                 120                 125             
Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Ala Val Leu
    130                 135                 140                 
Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser
145                 150                 155                 160 
Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly
                165                 170                 175     
Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile
            180                 185                 190         
Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly Ser Ala Phe Phe
        195                 200                 205             
Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp Gly Pro Gly Cys
    210                 215                 220                 
Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val Cys His Asp His
225                 230                 235                 240 
Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly Thr Arg Cys Glu
                245                 250                 255     
Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys Gln Glu Gln Cys
            260                 265                 270         
Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys Leu Pro Asp Pro
        275                 280                 285             
Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser Gln Cys Gln Glu
    290                 295                 300                 
Ala Cys Ala Pro Gly His Phe Gly Ala Asp Cys Arg Leu Gln Cys Gln
305                 310                 315                 320 
Cys Gln Asn Gly Gly Thr Cys Asp Arg Phe Ser Gly Cys Val Cys Pro
                325                 330                 335     
Ser Gly Trp His Gly Val His Cys Glu Lys Ser Asp Arg Ile Pro Gln
            340                 345                 350         
Ile Leu Asn Met Ala Ser Glu Leu Glu Phe Asn Leu Glu Thr Met Pro
        355                 360                 365             
Arg Ile Asn Cys Ala Ala Ala Gly Asn Pro Phe Pro Val Arg Gly Ser
    370                 375                 380                 
Ile Glu Leu Arg Lys Pro Asp Gly Thr Val Leu Leu Ser Thr Lys Ala
385                 390                 395                 400 
Ile Val Glu Pro Glu Lys Thr Thr Ala Glu Phe Glu Val Pro Arg Leu
                405                 410                 415     
Val Leu Ala Asp Ser Gly Phe Trp Glu Cys Arg Val Ser Thr Ser Gly
            420                 425                 430         
Gly Gln Asp Ser Arg Arg Phe Lys Val Asn Val Lys Val Pro Pro Val
        435                 440                 445             
Pro Leu Ala Ala Pro Arg Leu Leu Thr Lys Gln Ser Arg Gln Leu Val
    450                 455                 460                 
Val Ser Pro Leu Val Ser Phe Ser Gly Asp Gly Pro Ile Ser Thr Val
465                 470                 475                 480 
Arg Leu His Tyr Arg Pro Gln Asp Ser Thr Met Asp Trp Ser Thr Ile
                485                 490                 495     
Val Val Asp Pro Ser Glu Asn Val Thr Leu Met Asn Leu Arg Pro Lys
            500                 505                 510         
Thr Gly Tyr Ser Val Arg Val Gln Leu Ser Arg Pro Gly Glu Gly Gly
        515                 520                 525             
Glu Gly Ala Trp Gly Pro Pro Thr Leu Met Thr Thr Asp Cys Pro Glu
    530                 535                 540                 
Pro Leu Leu Gln Pro Trp Leu Glu Gly Trp His Val Glu Gly Thr Asp
545                 550                 555                 560 
Arg Leu Arg Val Ser Trp Ser Leu Pro Leu Val Pro Gly Pro Leu Val
                565                 570                 575     
Gly Asp Gly Phe Leu Leu Arg Leu Trp Asp Gly Thr Arg Gly Gln Glu
            580                 585                 590         
Arg Arg Glu Asn Val Ser Ser Pro Gln Ala Arg Thr Ala Leu Leu Thr
        595                 600                 605             
Gly Leu Thr Pro Gly Thr His Tyr Gln Leu Asp Val Gln Leu Tyr His
    610                 615                 620                 
Cys Thr Leu Leu Gly Pro Ala Ser Pro Pro Ala His Val Leu Leu Pro
625                 630                 635                 640 
Pro Ser Gly Pro Pro Ala Pro Arg His Leu His Ala Gln Ala Leu Ser
                645                 650                 655     
Asp Ser Glu Ile Gln Leu Thr Trp Lys His Pro Glu Ala Leu Pro Gly
            660                 665                 670         
Pro Ile Ser Lys Tyr Val Val Glu Val Gln Val Ala Gly Gly Ala Gly
        675                 680                 685             
Asp Pro Leu Trp Ile Asp Val Asp Arg Pro Glu Glu Thr Ser Thr Ile
    690                 695                 700                 
Ile Arg Gly Leu Asn Ala Ser Thr Arg Tyr Leu Phe Arg Met Arg Ala
705                 710                 715                 720 
Ser Ile Gln Gly Leu Gly Asp Trp Ser Asn Thr Val Glu Glu Ser Thr
                725                 730                 735     
Leu Gly Asn Gly Glu Arg Ala Gly Pro Thr Gly Pro Pro Gly Leu
            740                 745                 750     

<210> 264
<211> 838
<212> PRT
<213> Artificial Sequence

<220> 
<223> TIE.IFP

<400> 264
Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala
 1               5                  10                  15      
Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg
            20                  25                  30          
Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala
        35                  40                  45              
Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu
    50                  55                  60                  
Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu
65                  70                  75                  80  
Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro
                85                  90                  95      
Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg
            100                 105                 110         
Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu
        115                 120                 125             
Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Ala Val Leu
    130                 135                 140                 
Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser
145                 150                 155                 160 
Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly
                165                 170                 175     
Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile
            180                 185                 190         
Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly Ser Ala Phe Phe
        195                 200                 205             
Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp Gly Pro Gly Cys
    210                 215                 220                 
Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val Cys His Asp His
225                 230                 235                 240 
Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly Thr Arg Cys Glu
                245                 250                 255     
Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys Gln Glu Gln Cys
            260                 265                 270         
Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys Leu Pro Asp Pro
        275                 280                 285             
Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser Gln Cys Gln Glu
    290                 295                 300                 
Ala Cys Ala Pro Gly His Phe Gly Ala Asp Cys Arg Leu Gln Cys Gln
305                 310                 315                 320 
Cys Gln Asn Gly Gly Thr Cys Asp Arg Phe Ser Gly Cys Val Cys Pro
                325                 330                 335     
Ser Gly Trp His Gly Val His Cys Glu Lys Ser Asp Arg Ile Pro Gln
            340                 345                 350         
Ile Leu Asn Met Ala Ser Glu Leu Glu Phe Asn Leu Glu Thr Met Pro
        355                 360                 365             
Arg Ile Asn Cys Ala Ala Ala Gly Asn Pro Phe Pro Val Arg Gly Ser
    370                 375                 380                 
Ile Glu Leu Arg Lys Pro Asp Gly Thr Val Leu Leu Ser Thr Lys Ala
385                 390                 395                 400 
Ile Val Glu Pro Glu Lys Thr Thr Ala Glu Phe Glu Val Pro Arg Leu
                405                 410                 415     
Val Leu Ala Asp Ser Gly Phe Trp Glu Cys Arg Val Ser Thr Ser Gly
            420                 425                 430         
Gly Gln Asp Ser Arg Arg Phe Lys Val Asn Val Lys Val Pro Pro Val
        435                 440                 445             
Pro Leu Ala Ala Pro Arg Leu Leu Thr Lys Gln Ser Arg Gln Leu Val
    450                 455                 460                 
Val Ser Pro Leu Val Ser Phe Ser Gly Asp Gly Pro Ile Ser Thr Val
465                 470                 475                 480 
Arg Leu His Tyr Arg Pro Gln Asp Ser Thr Met Asp Trp Ser Thr Ile
                485                 490                 495     
Val Val Asp Pro Ser Glu Asn Val Thr Leu Met Asn Leu Arg Pro Lys
            500                 505                 510         
Thr Gly Tyr Ser Val Arg Val Gln Leu Ser Arg Pro Gly Glu Gly Gly
        515                 520                 525             
Glu Gly Ala Trp Gly Pro Pro Thr Leu Met Thr Thr Asp Cys Pro Glu
    530                 535                 540                 
Pro Leu Leu Gln Pro Trp Leu Glu Gly Trp His Val Glu Gly Thr Asp
545                 550                 555                 560 
Arg Leu Arg Val Ser Trp Ser Leu Pro Leu Val Pro Gly Pro Leu Val
                565                 570                 575     
Gly Asp Gly Phe Leu Leu Arg Leu Trp Asp Gly Thr Arg Gly Gln Glu
            580                 585                 590         
Arg Arg Glu Asn Val Ser Ser Pro Gln Ala Arg Thr Ala Leu Leu Thr
        595                 600                 605             
Gly Leu Thr Pro Gly Thr His Tyr Gln Leu Asp Val Gln Leu Tyr His
    610                 615                 620                 
Cys Thr Leu Leu Gly Pro Ala Ser Pro Pro Ala His Val Leu Leu Pro
625                 630                 635                 640 
Pro Ser Gly Pro Pro Ala Pro Arg His Leu His Ala Gln Ala Leu Ser
                645                 650                 655     
Asp Ser Glu Ile Gln Leu Thr Trp Lys His Pro Glu Ala Leu Pro Gly
            660                 665                 670         
Pro Ile Ser Lys Tyr Val Val Glu Val Gln Val Ala Gly Gly Ala Gly
        675                 680                 685             
Asp Pro Leu Trp Ile Asp Val Asp Arg Pro Glu Glu Thr Ser Thr Ile
    690                 695                 700                 
Ile Arg Gly Leu Asn Ala Ser Thr Arg Tyr Leu Phe Arg Met Arg Ala
705                 710                 715                 720 
Ser Ile Gln Gly Leu Gly Asp Trp Ser Asn Thr Val Glu Glu Ser Thr
                725                 730                 735     
Leu Gly Asn Gly Leu Gln Ala Glu Gly Pro Val Gln Glu Ser Arg Ala
            740                 745                 750         
Ala Glu Glu Gly Leu Asp Gln Gln Leu Ile Leu Ala Val Val Gly Ser
        755                 760                 765             
Val Ser Ala Thr Cys Leu Thr Ile Leu Ala Ala Leu Leu Thr Leu Val
    770                 775                 780                 
Cys Ile Arg Arg Ser Cys Leu His Arg Arg Arg Thr Phe Thr Tyr Gln
785                 790                 795                 800 
Ser Gly Ser Gly Glu Glu Thr Ile Leu Gln Phe Ser Ser Gly Thr Leu
                805                 810                 815     
Thr Leu Thr Arg Arg Pro Lys Leu Gln Pro Glu Pro Leu Ser Tyr Pro
            820                 825                 830         
Val Leu Glu Trp Glu Asp
        835             


<210> 265
<211> 632
<212> PRT
<213> Artificial Sequence

<220> 
<223> TIE.IFP

<400> 265
Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala
 1               5                  10                  15      
Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg
            20                  25                  30          
Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala
        35                  40                  45              
Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu
    50                  55                  60                  
Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu
65                  70                  75                  80  
Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro
                85                  90                  95      
Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg
            100                 105                 110         
Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu
        115                 120                 125             
Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Ala Val Leu
    130                 135                 140                 
Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser
145                 150                 155                 160 
Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly
                165                 170                 175     
Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile
            180                 185                 190         
Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly Ser Ala Phe Phe
        195                 200                 205             
Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp Gly Pro Gly Cys
    210                 215                 220                 
Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val Cys His Asp His
225                 230                 235                 240 
Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly Thr Arg Cys Glu
                245                 250                 255     
Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys Gln Glu Gln Cys
            260                 265                 270         
Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys Leu Pro Asp Pro
        275                 280                 285             
Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser Gln Cys Gln Glu
    290                 295                 300                 
Ala Cys Ala Pro Gly His Phe Gly Ala Asp Cys Arg Leu Gln Cys Gln
305                 310                 315                 320 
Cys Gln Asn Gly Gly Thr Cys Asp Arg Phe Ser Gly Cys Val Cys Pro
                325                 330                 335     
Ser Gly Trp His Gly Val His Cys Glu Lys Ser Asp Arg Ile Pro Gln
            340                 345                 350         
Ile Leu Asn Met Ala Ser Glu Leu Glu Phe Asn Leu Glu Thr Met Pro
        355                 360                 365             
Arg Ile Asn Cys Ala Ala Ala Gly Asn Pro Phe Pro Val Arg Gly Ser
    370                 375                 380                 
Ile Glu Leu Arg Lys Pro Asp Gly Thr Val Leu Leu Ser Thr Lys Ala
385                 390                 395                 400 
Ile Val Glu Pro Glu Lys Thr Thr Ala Glu Phe Glu Val Pro Arg Leu
                405                 410                 415     
Val Leu Ala Asp Ser Gly Phe Trp Glu Cys Arg Val Ser Thr Ser Gly
            420                 425                 430         
Gly Gln Asp Ser Arg Arg Phe Lys Val Asn Val Lys Val Pro Pro Val
        435                 440                 445             
Pro Leu Ala Ala Pro Arg Leu Leu Thr Lys Gln Ser Arg Gln Leu Val
    450                 455                 460                 
Val Ser Pro Leu Val Ser Phe Ser Gly Asp Gly Pro Ile Ser Thr Val
465                 470                 475                 480 
Arg Leu His Tyr Arg Pro Gln Asp Ser Thr Met Asp Trp Ser Thr Ile
                485                 490                 495     
Val Val Asp Pro Ser Glu Asn Val Thr Leu Met Asn Leu Arg Pro Lys
            500                 505                 510         
Thr Gly Tyr Ser Val Arg Val Gln Leu Ser Arg Pro Gly Glu Gly Gly
        515                 520                 525             
Glu Gly Ala Trp Gly Pro Pro Thr Leu Met Thr Thr Asp Cys Pro Glu
    530                 535                 540                 
Pro Leu Leu Gln Pro Trp Leu Glu Gly Trp His Val Glu Gly Thr Asp
545                 550                 555                 560 
Arg Leu Arg Val Ser Trp Ser Leu Pro Leu Val Pro Gly Pro Leu Val
                565                 570                 575     
Gly Asp Gly Phe Leu Leu Arg Leu Trp Asp Gly Thr Arg Gly Gln Glu
            580                 585                 590         
Arg Arg Glu Asn Val Ser Ser Pro Gln Ala Arg Thr Ala Leu Leu Thr
        595                 600                 605             
Gly Leu Thr Pro Gly Thr His Tyr Gln Leu Asp Val Gln Leu Tyr His
    610                 615                 620                 
Cys Thr Leu Leu Gly Pro Ala Ser
625                 630         


<210> 266
<211> 533
<212> PRT
<213> Artificial Sequence

<220> 
<223> TIE.IFP

<400> 266
Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala
 1               5                  10                  15      
Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg
            20                  25                  30          
Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala
        35                  40                  45              
Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu
    50                  55                  60                  
Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu
65                  70                  75                  80  
Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro
                85                  90                  95      
Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg
            100                 105                 110         
Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu
        115                 120                 125             
Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Ala Val Leu
    130                 135                 140                 
Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser
145                 150                 155                 160 
Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly
                165                 170                 175     
Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile
            180                 185                 190         
Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly Ser Ala Phe Phe
        195                 200                 205             
Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp Gly Pro Gly Cys
    210                 215                 220                 
Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val Cys His Asp His
225                 230                 235                 240 
Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly Thr Arg Cys Glu
                245                 250                 255     
Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys Gln Glu Gln Cys
            260                 265                 270         
Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys Leu Pro Asp Pro
        275                 280                 285             
Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser Gln Cys Gln Glu
    290                 295                 300                 
Ala Cys Ala Pro Gly His Phe Gly Ala Asp Cys Arg Leu Gln Cys Gln
305                 310                 315                 320 
Cys Gln Asn Gly Gly Thr Cys Asp Arg Phe Ser Gly Cys Val Cys Pro
                325                 330                 335     
Ser Gly Trp His Gly Val His Cys Glu Lys Ser Asp Arg Ile Pro Gln
            340                 345                 350         
Ile Leu Asn Met Ala Ser Glu Leu Glu Phe Asn Leu Glu Thr Met Pro
        355                 360                 365             
Arg Ile Asn Cys Ala Ala Ala Gly Asn Pro Phe Pro Val Arg Gly Ser
    370                 375                 380                 
Ile Glu Leu Arg Lys Pro Asp Gly Thr Val Leu Leu Ser Thr Lys Ala
385                 390                 395                 400 
Ile Val Glu Pro Glu Lys Thr Thr Ala Glu Phe Glu Val Pro Arg Leu
                405                 410                 415     
Val Leu Ala Asp Ser Gly Phe Trp Glu Cys Arg Val Ser Thr Ser Gly
            420                 425                 430         
Gly Gln Asp Ser Arg Arg Phe Lys Val Asn Val Lys Val Pro Pro Val
        435                 440                 445             
Pro Leu Ala Ala Pro Arg Leu Leu Thr Lys Gln Ser Arg Gln Leu Val
    450                 455                 460                 
Val Ser Pro Leu Val Ser Phe Ser Gly Asp Gly Pro Ile Ser Thr Val
465                 470                 475                 480 
Arg Leu His Tyr Arg Pro Gln Asp Ser Thr Met Asp Trp Ser Thr Ile
                485                 490                 495     
Val Val Asp Pro Ser Glu Asn Val Thr Leu Met Asn Leu Arg Pro Lys
            500                 505                 510         
Thr Gly Tyr Ser Val Arg Val Gln Leu Ser Arg Pro Gly Glu Gly Gly
        515                 520                 525             
Glu Gly Ala Trp Gly
    530             


<210> 267
<211> 428
<212> PRT
<213> Artificial Sequence

<220> 
<223> TIE.IFP

<400> 267
Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala
 1               5                  10                  15      
Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg
            20                  25                  30          
Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala
        35                  40                  45              
Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu
    50                  55                  60                  
Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu
65                  70                  75                  80  
Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro
                85                  90                  95      
Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg
            100                 105                 110         
Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu
        115                 120                 125             
Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Ala Val Leu
    130                 135                 140                 
Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser
145                 150                 155                 160 
Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly
                165                 170                 175     
Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile
            180                 185                 190         
Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly Ser Ala Phe Phe
        195                 200                 205             
Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp Gly Pro Gly Cys
    210                 215                 220                 
Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val Cys His Asp His
225                 230                 235                 240 
Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly Thr Arg Cys Glu
                245                 250                 255     
Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys Gln Glu Gln Cys
            260                 265                 270         
Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys Leu Pro Asp Pro
        275                 280                 285             
Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser Gln Cys Gln Glu
    290                 295                 300                 
Ala Cys Ala Pro Gly His Phe Gly Ala Asp Cys Arg Leu Gln Cys Gln
305                 310                 315                 320 
Cys Gln Asn Gly Gly Thr Cys Asp Arg Phe Ser Gly Cys Val Cys Pro
                325                 330                 335     
Ser Gly Trp His Gly Val His Cys Glu Lys Ser Asp Arg Ile Pro Gln
            340                 345                 350         
Ile Leu Asn Met Ala Ser Glu Leu Glu Phe Asn Leu Glu Thr Met Pro
        355                 360                 365             
Arg Ile Asn Cys Ala Ala Ala Gly Asn Pro Phe Pro Val Arg Gly Ser
    370                 375                 380                 
Ile Glu Leu Arg Lys Pro Asp Gly Thr Val Leu Leu Ser Thr Lys Ala
385                 390                 395                 400 
Ile Val Glu Pro Glu Lys Thr Thr Ala Glu Phe Glu Val Pro Arg Leu
                405                 410                 415     
Val Leu Ala Asp Ser Gly Phe Trp Glu Cys Arg Val
            420                 425             


<210> 268
<211> 344
<212> PRT
<213> Artificial Sequence

<220> 
<223> TIE.IFP

<400> 268
Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala
 1               5                  10                  15      
Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg
            20                  25                  30          
Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala
        35                  40                  45              
Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu
    50                  55                  60                  
Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu
65                  70                  75                  80  
Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro
                85                  90                  95      
Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg
            100                 105                 110         
Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu
        115                 120                 125             
Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Ala Val Leu
    130                 135                 140                 
Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser
145                 150                 155                 160 
Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly
                165                 170                 175     
Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile
            180                 185                 190         
Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly Ser Ala Phe Phe
        195                 200                 205             
Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp Gly Pro Gly Cys
    210                 215                 220                 
Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val Cys His Asp His
225                 230                 235                 240 
Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly Thr Arg Cys Glu
                245                 250                 255     
Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys Gln Glu Gln Cys
            260                 265                 270         
Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys Leu Pro Asp Pro
        275                 280                 285             
Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser Gln Cys Gln Glu
    290                 295                 300                 
Ala Cys Ala Pro Gly His Phe Gly Ala Asp Cys Arg Leu Gln Cys Gln
305                 310                 315                 320 
Cys Gln Asn Gly Gly Thr Cys Asp Arg Phe Ser Gly Cys Val Cys Pro
                325                 330                 335     
Ser Gly Trp His Gly Val His Cys
            340                 


<210> 269
<211> 255
<212> PRT
<213> Artificial Sequence

<220> 
<223> TIE.IFP

<400> 269
Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala
 1               5                  10                  15      
Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg
            20                  25                  30          
Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala
        35                  40                  45              
Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu
    50                  55                  60                  
Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu
65                  70                  75                  80  
Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro
                85                  90                  95      
Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg
            100                 105                 110         
Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu
        115                 120                 125             
Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Ala Val Leu
    130                 135                 140                 
Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser
145                 150                 155                 160 
Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly
                165                 170                 175     
Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile
            180                 185                 190         
Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly Ser Ala Phe Phe
        195                 200                 205             
Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp Gly Pro Gly Cys
    210                 215                 220                 
Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val Cys His Asp His
225                 230                 235                 240 
Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly Thr Arg Cys
                245                 250                 255 


<210> 270
<211> 197
<212> PRT
<213> Artificial Sequence

<220> 
<223> TIE.IFP

<400> 270
Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala
 1               5                  10                  15      
Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg
            20                  25                  30          
Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala
        35                  40                  45              
Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu
    50                  55                  60                  
Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu
65                  70                  75                  80  
Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro
                85                  90                  95      
Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg
            100                 105                 110         
Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu
        115                 120                 125             
Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Ala Val Leu
    130                 135                 140                 
Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser
145                 150                 155                 160 
Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly
                165                 170                 175     
Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile
            180                 185                 190         
Tyr Ser Ala Thr Tyr
        195     

<210> 271
<211> 913
<212> DNA
<213> Homo sapiens

<220> 
<223> SR003H02

<400> 271
agaaggcgct gggctgcgag ggcgcgaggg cgcgagggca gggggcaacc ggaccccgcc 60
cgcacccatg gcgcccgtcg ccgtctgggc cgcgctggcc gtcggactgg agctctgggc 120
tgcggcgcac gccttgcccg cccaggtggc atttacaccc tacgccccgg agcccgggag 180
cacatgccgg ctcagagaat actatgacca gacagctcag atgtgctgca gcaaatgctc 240
gccgggccaa catgcaaaag tcttctgtac caagacctcg gacaccgtgt gtgactcctg 300
tgaggacagc acatacaccc agctctggaa ctgggttccc gagtgcttga gctgtggctc 360
ccgctgtagc tctgaccagg tggaaactca agcctgcact cgggaacaga accgcatctg 420
cacctgcagg cccggctggt actgcgcgct gagcaagcag gaggggtgcc ggctgtgcgc 480
gccgctgcgc aagtgccgcc cgggcttcgg cgtggccaga ccagacctct cctagggctc 540
tagtgccaag gcccagctgt cccgcagagt gtctgagtgg ttgacaagtt cggattgttc 600
cctgaaggaa ctgaaacatc agacgtggtg tgcaagccct gtgccccggg gacgttctcc 660
aacacgactt catccacgga tatttgcagg ccccaccaga tctgtaacgt ggtggccatc 720
cctgggaatg caagcatgga tgcagtctgc acgtccacgt cccccacccg gagtatggcc 780
ccaggggcag tacacttacc ccagccagtg tccacacgat cccaacacac gcagccaact 840
ccagaaccca gcactgctcc aagcacctcc ttcctgctcc caatgggccc cagcccccca 900
gctgaaggga gca                                                    913

<210> 272
<211> 155
<212> PRT
<213> Homo sapiens

<220> 
<223> SR003H02

<400> 272
Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu
 1               5                  10                  15      
Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr
            20                  25                  30          
Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln
        35                  40                  45              
Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys
    50                  55                  60                  
Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp
65                  70                  75                  80  
Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys
                85                  90                  95      
Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg
            100                 105                 110         
Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu
        115                 120                 125             
Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg
    130                 135                 140                 
Pro Gly Phe Gly Val Ala Arg Pro Asp Leu Ser
145                 150                 155 

<210> 273
<211> 923
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (253)...(777)
<223> SR004C05

<400> 273
gcggacactc ctctcggctc ctccccggca gcggcggcgg ctcggagcgg gctccggggc 60
tcgggtgcag cggccagcgg gcgcctggcg gcgaggatta cccggggaag tggttgtctc 120
ctggctggag ccgcgagacg ggcgctcagg gcgcggggcc ggcggcggcg aacgagagga 180
cggactctgg cggccgggtc gttggccgcg gggagcgcgg gcaccgggcg agcaggccgc 240
gtcgcgctca cc atg gtc agc tac tgg gac acc ggg gtc ctg ctg tgc gcg 291
              Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala
               1               5                   10
 
ctg ctc agc tgt ctg ctt ctc aca gga tct agt tca ggt tca aaa tta   339
Leu Leu Ser Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu
     15                  20                  25
 
aaa gat cct gaa ctg agt tta aaa ggc acc cag cac atc atg caa gca   387
Lys Asp Pro Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala
 30                  35                  40                  45
 
ggc cag aca ctg cat ctc caa tgc agg ggg gaa gca gcc cat aaa tgg   435
Gly Gln Thr Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp
                 50                  55                  60
 
tct ttg cct gaa atg gtg agt aag gaa agc gaa agg ctg agc ata act   483
Ser Leu Pro Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr
             65                  70                  75
 
aaa tct gcc tgt gga aga aat ggc aaa caa ttc tgc agt act tta acc   531
Lys Ser Ala Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr
         80                  85                  90
 
ttg aac aca gct caa gca aac cac act ggc ttc tac agc tgc aaa tat   579
Leu Asn Thr Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr
     95                 100                 105
 
cta gct gta cct act tca aag aag aag gaa aca gaa tct gca atc tat   627
Leu Ala Val Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr
110                 115                 120                 125
 
ata ttt att agt gat aca ggt aga cct ttc gta gag atg tac agt gaa   675
Ile Phe Ile Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu
                130                 135                 140
 
atc ccc gaa att ata cac atg act gaa gga agg gag ctc gtc att ccc   723
Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro
            145                 150                 155
 
tgc cgg gtt acg tca cct aac atc act gtt act tta aaa aag aag aag   771
Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Lys Lys
        160                 165                 170
 
gca taa ggagaaagtc agatcatgga ttattttctt ctgtttggac tcaccgtgct    827
Ala  *

 
tgggaatact tctgagcatt agagagcact tcattcattg cagagtctct ggcctccgag 887
gctgccttca ccatcagcag cttcagcttc tgggag                           923

<210> 274
<211> 174
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR004C05

<400> 274
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser
 1               5                  10                  15      
Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro
            20                  25                  30          
Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr
        35                  40                  45              
Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro
    50                  55                  60                  
Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala
65                  70                  75                  80  
Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr
                85                  90                  95      
Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val
            100                 105                 110         
Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile
        115                 120                 125             
Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu
    130                 135                 140                 
Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val
145                 150                 155                 160 
Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Lys Lys Ala
                165                 170                 

<210> 275
<211> 479
<212> PRT
<213> Homo sapiens

<220> 
<223> FLT1.c 31

<400> 275
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser
 1               5                  10                  15      
Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro
            20                  25                  30          
Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr
        35                  40                  45              
Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro
    50                  55                  60                  
Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala
65                  70                  75                  80  
Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr
                85                  90                  95      
Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val
            100                 105                 110         
Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile
        115                 120                 125             
Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu
    130                 135                 140                 
Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val
145                 150                 155                 160 
Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr
                165                 170                 175     
Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe
            180                 185                 190         
Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu
        195                 200                 205             
Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg
    210                 215                 220                 
Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val
225                 230                 235                 240 
Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr
                245                 250                 255     
Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys
            260                 265                 270         
Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His
        275                 280                 285             
Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys
    290                 295                 300                 
Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys
305                 310                 315                 320 
Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val
                325                 330                 335     
Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser
            340                 345                 350         
Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val
        355                 360                 365             
Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu
    370                 375                 380                 
Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala
385                 390                 395                 400 
Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys
                405                 410                 415     
Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu
            420                 425                 430         
Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser
        435                 440                 445             
Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile
    450                 455                 460                 
Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg
465                 470                 475                 

<210> 276
<211> 523
<212> PRT
<213> Homo sapiens

<220> 
<223> FLT1.c 32

<400> 276
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser
 1               5                  10                  15      
Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro
            20                  25                  30          
Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr
        35                  40                  45              
Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro
    50                  55                  60                  
Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala
65                  70                  75                  80  
Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr
                85                  90                  95      
Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val
            100                 105                 110         
Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile
        115                 120                 125             
Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu
    130                 135                 140                 
Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val
145                 150                 155                 160 
Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr
                165                 170                 175     
Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe
            180                 185                 190         
Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu
        195                 200                 205             
Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg
    210                 215                 220                 
Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val
225                 230                 235                 240 
Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr
                245                 250                 255     
Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys
            260                 265                 270         
Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His
        275                 280                 285             
Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys
    290                 295                 300                 
Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys
305                 310                 315                 320 
Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val
                325                 330                 335     
Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser
            340                 345                 350         
Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val
        355                 360                 365             
Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu
    370                 375                 380                 
Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala
385                 390                 395                 400 
Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys
                405                 410                 415     
Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu
            420                 425                 430         
Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile Lys Trp
        435                 440                 445             
Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys Asp Phe
    450                 455                 460                 
Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser Asn Met
465                 470                 475                 480 
Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile Glu Gly
                485                 490                 495     
Lys Asn Lys Leu Pro Pro Ala Asn Ser Ser Phe Met Leu Pro Pro Thr
            500                 505                 510         
Ser Phe Ser Ser Asn Tyr Phe His Phe Leu Pro
        515                 520             

<210> 277
<211> 436
<212> PRT
<213> Homo sapiens

<220> 
<223> FLT1.c 33

<400> 277
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser
 1               5                  10                  15      
Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro
            20                  25                  30          
Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr
        35                  40                  45              
Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro
    50                  55                  60                  
Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala
65                  70                  75                  80  
Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr
                85                  90                  95      
Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val
            100                 105                 110         
Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile
        115                 120                 125             
Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu
    130                 135                 140                 
Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val
145                 150                 155                 160 
Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr
                165                 170                 175     
Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe
            180                 185                 190         
Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu
        195                 200                 205             
Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg
    210                 215                 220                 
Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val
225                 230                 235                 240 
Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr
                245                 250                 255     
Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys
            260                 265                 270         
Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His
        275                 280                 285             
Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys
    290                 295                 300                 
Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys
305                 310                 315                 320 
Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val
                325                 330                 335     
Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser
            340                 345                 350         
Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val
        355                 360                 365             
Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu
    370                 375                 380                 
Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Lys Asn Leu Thr Ala Thr
385                 390                 395                 400 
Leu Ile Val Asn Val Lys Pro Gln Glu Arg Ile Arg Glu Arg Ile Ser
                405                 410                 415     
Pro Asp Leu Tyr Arg Ile Trp Tyr Pro Ser Thr Tyr Asn Gln Val Val
            420                 425                 430         
Leu Ala Pro Leu
        435     


<210> 278
<211> 365
<212> PRT
<213> Homo sapiens

<220> 
<223> FLT1.c 34

<400> 278
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser
 1               5                  10                  15      
Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro
            20                  25                  30          
Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr
        35                  40                  45              
Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro
    50                  55                  60                  
Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala
65                  70                  75                  80  
Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr
                85                  90                  95      
Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val
            100                 105                 110         
Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile
        115                 120                 125             
Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu
    130                 135                 140                 
Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val
145                 150                 155                 160 
Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr
                165                 170                 175     
Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe
            180                 185                 190         
Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu
        195                 200                 205             
Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg
    210                 215                 220                 
Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val
225                 230                 235                 240 
Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr
                245                 250                 255     
Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys
            260                 265                 270         
Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His
        275                 280                 285             
Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys
    290                 295                 300                 
Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys
305                 310                 315                 320 
Ser Val Asn Thr Ser Val His Ile Tyr Gly Lys His Ser Ser Ala Leu
                325                 330                 335     
Pro Thr His Ala Met Leu Ser Asn His Cys Arg Cys Leu Cys Ser Leu
            340                 345                 350         
Asn Lys Ser Val Phe Cys Trp Pro Arg Val Thr Leu Ser
        355                 360                 365 

<210> 279
<211> 541
<212> PRT
<213> Homo sapiens

<220> 
<223> SR018C02

<400> 279
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser
 1               5                  10                  15      
Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro
            20                  25                  30          
Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr
        35                  40                  45              
Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro
    50                  55                  60                  
Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala
65                  70                  75                  80  
Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr
                85                  90                  95      
Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val
            100                 105                 110         
Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile
        115                 120                 125             
Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu
    130                 135                 140                 
Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val
145                 150                 155                 160 
Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr
                165                 170                 175     
Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe
            180                 185                 190         
Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu
        195                 200                 205             
Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg
    210                 215                 220                 
Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val
225                 230                 235                 240 
Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr
                245                 250                 255     
Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys
            260                 265                 270         
Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His
        275                 280                 285             
Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys
    290                 295                 300                 
Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys
305                 310                 315                 320 
Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val
                325                 330                 335     
Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser
            340                 345                 350         
Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val
        355                 360                 365             
Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu
    370                 375                 380                 
Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala
385                 390                 395                 400 
Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys
                405                 410                 415     
Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu
            420                 425                 430         
Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser
        435                 440                 445             
Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile
    450                 455                 460                 
Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys
465                 470                 475                 480 
Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser
                485                 490                 495     
Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile
            500                 505                 510         
Glu Gly Lys Asn Lys Leu Pro Pro Ala Asn Ser Ser Phe Met Leu Pro
        515                 520                 525             
Pro Thr Ser Phe Ser Ser Asn Tyr Phe His Phe Leu Pro
    530                 535                 540     

<210> 280
<211> 687
<212> PRT
<213> Artificial Sequence

<220> 
<223> FLT1.d BUILD 31

<400> 280
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser
 1               5                  10                  15      
Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro
            20                  25                  30          
Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr
        35                  40                  45              
Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro
    50                  55                  60                  
Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala
65                  70                  75                  80  
Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr
                85                  90                  95      
Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val
            100                 105                 110         
Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile
        115                 120                 125             
Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu
    130                 135                 140                 
Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val
145                 150                 155                 160 
Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr
                165                 170                 175     
Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe
            180                 185                 190         
Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu
        195                 200                 205             
Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg
    210                 215                 220                 
Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val
225                 230                 235                 240 
Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr
                245                 250                 255     
Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys
            260                 265                 270         
Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His
        275                 280                 285             
Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys
    290                 295                 300                 
Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys
305                 310                 315                 320 
Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val
                325                 330                 335     
Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser
            340                 345                 350         
Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val
        355                 360                 365             
Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu
    370                 375                 380                 
Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala
385                 390                 395                 400 
Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys
                405                 410                 415     
Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu
            420                 425                 430         
Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser
        435                 440                 445             
Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile
    450                 455                 460                 
Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys
465                 470                 475                 480 
Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser
                485                 490                 495     
Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile
            500                 505                 510         
Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg
        515                 520                 525             
Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val
    530                 535                 540                 
Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His
545                 550                 555                 560 
Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser
                565                 570                 575     
Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu
            580                 585                 590         
Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys
        595                 600                 605             
Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met
    610                 615                 620                 
Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn
625                 630                 635                 640 
Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg
                645                 650                 655     
Gly Glu His Cys Asn Lys Lys Ala Val Phe Ser Arg Ile Ser Lys Phe
            660                 665                 670         
Lys Ser Thr Arg Asn Asp Cys Thr Thr Gln Ser Asn Val Lys His
        675                 680                 685         

<210> 281
<211> 2432
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR015F01

<400> 281
catttcgccc ggctcgaggt gcaggatgca gagcaaggtg ctgctggccg tcgccctgtg 60
gctctgcgtg gagacccggg ccgcctctgt gggtttgcct agtgtttctc ttgatctgcc 120
caggctcagc atacaaaaag acatacttac aattaaggct aatacaactc ttcaaattac 180
ttgcagggga cagagggact tggactggct ttggcccaat aatcagagtg gcagtgagca 240
aagggtggag gtgactgagt gcagcgatgg cctcttctgt aagacactca caattccaaa 300
agtgatcgga aatgacactg gagcctacaa gtgcttctac cgggaaactg acttggcctc 360
ggtcatttat gtctatgttc aagattacag atctccattt attgcttctg ttagtgacca 420
acatggagtc gtgtacatta ctgagaacaa aaacaaaact gtggtgattc catgtctcgg 480
gtccatttca aatctcaacg tgtcactttg tgcaagatac ccagaaaaga gatttgttcc 540
tgatggtaac agaatttcct gggacagcaa gaagggcttt actattccca gctacatgat 600
cagctatgct ggcatggtct tctgtgaagc aaaaattaat gatgaaagtt accagtctat 660
tatgtacata gttgtcgttg tagggtatag gatttatgat gtggttctga gtccgtctca 720
tggaattgaa ctatctgttg gagaaaagct tgtcttaaat tgtacagcaa gaactgaact 780
aaatgtgggg attgacttca actgggaata cccttcttcg aagcatcagc ataagaaact 840
tgtaaaccga gacctaaaaa cccagtctgg gagtgagatg aagaaatttt tgagcacctt 900
aactatagat ggtgtaaccc ggagtgacca aggattgtac acctgtgcag catccagtgg 960
gctgatgacc aagaagaaca gcacatttgt cagggtccat gaaaaacctt ttgttgcttt 1020
tggaagtggc atggaatctc tggtggaagc cacggtgggg gagcgtgtca gaatccctgc 1080
gaagtacctt ggttacccac ccccagaaat aaaatggtat aaaaatggaa taccccttga 1140
gtccaatcac acaattaaag cggggcatgt actgacgatt atggaagtga gtgaaagaga 1200
cacaggaaat tacactgtca tccttaccaa tcccatttca aaggagaagc agagccatgt 1260
ggtctctctg gttgtgtatg tcccacccca gattggtgag aaatctctaa tctctcctgt 1320
ggattcctac cagtacggca ccactcaaac gctgacatgt acggtctatg ccattcctcc 1380
cccgcatcac atccactggt attggcagtt ggaggaagag tgcgccaacg agcccagcca 1440
agctgtctca gtgacaaacc catacccttg tgaagaatgg agaagtgtgg aggacttcca 1500
gggaggaaat aaaattgaag ttaataaaaa tcaatttgct ctaattgaag gaaaaaacaa 1560
aactgtaagt acccttgtta tccaagcggc aaatgtgtca gctttgtaca aatgtgaagc 1620
ggtcaacaaa gtcgggagag gagagagggt gatctccttc cacgtgacca ggggtcctga 1680
aattactttg caacctgaca tgcagcccac tgagcaggag agcgtgtctt tgtggtgcac 1740
tgcagacaga tctacgtttg agaacctcac atggtacaag cttggcccac agcctctgcc 1800
aatccatgtg ggagagttgc ccacacctgt ttgcaagaac ttggatactc tttggaaatt 1860
gaatgccacc atgttctcta atagcacaaa tgacattttg atcatggagc ttaagaatgc 1920
atccttgcag gaccaaggag actatgtctg ccttgctcaa gacaggaaga ccaagaaaag 1980
acattgcgtg gtcaggcagc tcacagtcct agagcgtgtg gcacccacga tcacaggaaa 2040
cctggagaat cagacgacaa gtattgggga aagcatcgaa gtctcatgca cggcatctgg 2100
gaatccccct ccacagatca tgtggtttaa agataatgag acccttgtag aagactcaga 2160
gtgaggaagg aggacgaagg cctctacacc tgccaggcat gcagtgttct tggctgtgca 2220
aaagtggagg catttttcat aatagaaggt gcccaggaaa agacgaactt ggaaatcatt 2280
attctagtag gcacggcggt gattgccatg ttcttctggc tacttcttgt catcatccta 2340
cggaccgtta agcgggccaa tggaggggaa ctgaagacag gctacttgtc catcgtcatg 2400
gatccagatg aactcccatt ggatgaacat tg                               2432

<210> 282
<211> 712
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR015F01

<400> 282
Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu
 1               5                  10                  15      
Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro
            20                  25                  30          
Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr
        35                  40                  45              
Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro
    50                  55                  60                  
Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser
65                  70                  75                  80  
Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn
                85                  90                  95      
Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser
            100                 105                 110         
Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser
        115                 120                 125             
Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys
    130                 135                 140                 
Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser
145                 150                 155                 160 
Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg
                165                 170                 175     
Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile
            180                 185                 190         
Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser
        195                 200                 205             
Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr
    210                 215                 220                 
Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu
225                 230                 235                 240 
Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile
                245                 250                 255     
Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu
            260                 265                 270         
Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe
        275                 280                 285             
Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu
    290                 295                 300                 
Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr
305                 310                 315                 320 
Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met
                325                 330                 335     
Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala
            340                 345                 350         
Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly
        355                 360                 365             
Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr
    370                 375                 380                 
Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu
385                 390                 395                 400 
Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val
                405                 410                 415     
Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val
            420                 425                 430         
Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr
        435                 440                 445             
Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu
    450                 455                 460                 
Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr
465                 470                 475                 480 
Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys
                485                 490                 495     
Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys
            500                 505                 510         
Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr
        515                 520                 525             
Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser
    530                 535                 540                 
Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln
545                 550                 555                 560 
Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser
                565                 570                 575     
Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro
            580                 585                 590         
Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr
        595                 600                 605             
Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile
    610                 615                 620                 
Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr
625                 630                 635                 640 
Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val
                645                 650                 655     
Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn
            660                 665                 670         
Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys
        675                 680                 685             
Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn
    690                 695                 700                 
Glu Thr Leu Val Glu Asp Ser Glu
705                 710         

<210> 283
<211> 783
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (17)...(700)
<223> SR007E10

<400> 283
cgcgcagcgg ccggag atg cag cgg ggc gcc gcg ctg tgc ctg cga ctg tgg 52
                  Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp
                   1               5                   10
 
ctc tgc ctg gga ctc ctg gac ggc ctg gtg agt ggc tac tcc atg acc   100
Leu Cys Leu Gly Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr
         15                  20                  25
 
ccc ccg acc ttg aac atc acg gag gag tca cac gtc atc gac acc ggt   148
Pro Pro Thr Leu Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly
     30                  35                  40
 
gac agc ctg tcc atc tcc tgc agg gga cag cac ccc ctc gag tgg gct   196
Asp Ser Leu Ser Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala
 45                  50                  55                  60
 
tgg cca gga gct cag gag gcg cca gcc acc gga gac aag gac agc gag   244
Trp Pro Gly Ala Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu
                 65                  70                  75
 
gac acg ggg gtg gtg cga gac tgc gag ggc aca gac gcc agg ccc tac   292
Asp Thr Gly Val Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr
             80                  85                  90
 
tgc aag gtg ttg ctg ctg cac gag gta cat gcc aac gac aca ggc agc   340
Cys Lys Val Leu Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser
         95                 100                 105
 
tac gtc tgc tac tac aag tac atc aag gca cgc atc gag ggc acc acg   388
Tyr Val Cys Tyr Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr
    110                 115                 120
 
gcc gcc agc tcc tac gtg ttc gtg aga gga agg acg cca tgt ggg tgc   436
Ala Ala Ser Ser Tyr Val Phe Val Arg Gly Arg Thr Pro Cys Gly Cys
125                 130                 135                 140
 
cct gtc tgg tgt cca tcc ccg gcc tca atg tca cgc tgc gct cgc aaa   484
Pro Val Trp Cys Pro Ser Pro Ala Ser Met Ser Arg Cys Ala Arg Lys
                145                 150                 155
 
gct cgg tgc tgt ggc cag acg ggc agg agg tgg tgt ggg atg acc ggc   532
Ala Arg Cys Cys Gly Gln Thr Gly Arg Arg Trp Cys Gly Met Thr Gly
            160                 165                 170
 
ggg gca tgc tcg tgt cca cgc cac tgc tgc acg atg ccc tgt acc tgc   580
Gly Ala Cys Ser Cys Pro Arg His Cys Cys Thr Met Pro Cys Thr Cys
        175                 180                 185
 
agt gcg aga cca cct ggg gag acc agg act tcc ttt cca acc cct tcc   628
Ser Ala Arg Pro Pro Gly Glu Thr Arg Thr Ser Phe Pro Thr Pro Ser
    190                 195                 200
 
tgg tgc aca tca cag gca acg agc tct atg aca tcc agc tgt tgc cca   676
Trp Cys Thr Ser Gln Ala Thr Ser Ser Met Thr Ser Ser Cys Cys Pro
205                 210                 215                 220
 
gga agt cgc tgg agc tgc tgg tag gggagaagct ggtcctgaac tgcaccgtgt  730
Gly Ser Arg Trp Ser Cys Trp  *
                225
 
gggctgagtt taactcaggt gtcacctttg actgggacta cccagggaag cag        783

<210> 284
<211> 227
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR007E10

<400> 284
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15      
Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30          
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45              
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60                  
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80  
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95      
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110         
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125             
Tyr Val Phe Val Arg Gly Arg Thr Pro Cys Gly Cys Pro Val Trp Cys
    130                 135                 140                 
Pro Ser Pro Ala Ser Met Ser Arg Cys Ala Arg Lys Ala Arg Cys Cys
145                 150                 155                 160 
Gly Gln Thr Gly Arg Arg Trp Cys Gly Met Thr Gly Gly Ala Cys Ser
                165                 170                 175     
Cys Pro Arg His Cys Cys Thr Met Pro Cys Thr Cys Ser Ala Arg Pro
            180                 185                 190         
Pro Gly Glu Thr Arg Thr Ser Phe Pro Thr Pro Ser Trp Cys Thr Ser
        195                 200                 205             
Gln Ala Thr Ser Ser Met Thr Ser Ser Cys Cys Pro Gly Ser Arg Trp
    210                 215                 220                 
Ser Cys Trp
225         

<210> 285
<211> 1356
<212> DNA
<213> Homo Sapiens

<220> 
<221> CDS            
<222> (16)...(903)
<223> SR007F05

<400> 285
gcgcagcggc cggag atg cag cgg ggc gcc gcg ctg tgc ctg cga ctg tgg  51
                 Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp
                  1               5                   10
 
ctc tgc ctg gga ctc ctg gac ggc ctg gtg agt ggc tac tcc atg acc   99
Leu Cys Leu Gly Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr
         15                  20                  25
 
ccc ccg acc ttg aac atc acg gag gag tca cac gtc atc gac acc ggt   147
Pro Pro Thr Leu Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly
     30                  35                  40
 
gac agc ctg tcc atc tcc tgc agg gga cag cac ccc ctc gag tgg gct   195
Asp Ser Leu Ser Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala
 45                  50                  55                  60
 
tgg cca gga gct cag gag gcg cca gcc acc gga gac aag gac agc gag   243
Trp Pro Gly Ala Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu
                 65                  70                  75
 
gac acg ggg gtg gtg cga gac tgc gag ggc aca gac gcc agg ccc tac   291
Asp Thr Gly Val Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr
             80                  85                  90
 
tgc aag gtg ttg ctg ctg cac gag gta cat gcc aac gac aca ggc agc   339
Cys Lys Val Leu Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser
         95                 100                 105
 
tac gtc tgc tac tac aag tac atc aag gca cgc atc gag ggc acc acg   387
Tyr Val Cys Tyr Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr
    110                 115                 120
 
gcc gcc agc tcc tac gtg ttc gtg aga gac ttt gag cag cca ttc atc   435
Ala Ala Ser Ser Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile
125                 130                 135                 140
 
aac aag cct gac acg ctc ttg gtc aac agg aag gac gcc atg tgg gtg   483
Asn Lys Pro Asp Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val
                145                 150                 155
 
ccc tgt ctg gtg tcc atc ccc ggc ctc aat gtc acg ctg cgc tcg caa   531
Pro Cys Leu Val Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln
            160                 165                 170
 
agc tcg gtg ctg tgg cca gac ggg cag gag gtg gtg tgg gat gac cgg   579
Ser Ser Val Leu Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg
        175                 180                 185
 
cgg ggc atg ctc gtg tcc acg cca ctg ctg cac gat gcc ctg tac ctg   627
Arg Gly Met Leu Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu
    190                 195                 200
 
cag tgc gag acc acc tgg gga gac cag gac ttc ctt tcc aac ccc ttc   675
Gln Cys Glu Thr Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe
205                 210                 215                 220
 
ctg gtg cac atc aca ggc aac gag ctc tat gac atc cag ctg ttg ccc   723
Leu Val His Ile Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro
                225                 230                 235
 
agg aag tcg ctg gag ctg ctg gta ggg gag aag ctg gtc ctg aac tgc   771
Arg Lys Ser Leu Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys
            240                 245                 250
 
acc gtg tgg gct gag ttt aac tca ggt gtc acc ttt gac tgg gac tac   819
Thr Val Trp Ala Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr
        255                 260                 265
 
cca ggg aag cag aaa atc cct tca tca gcg tcg agt ggc tca aag gac   867
Pro Gly Lys Gln Lys Ile Pro Ser Ser Ala Ser Ser Gly Ser Lys Asp
    270                 275                 280
 
cca tcc tgg agg cca cgg cag gag acg agc tgg tga agctgcccgt        913
Pro Ser Trp Arg Pro Arg Gln Glu Thr Ser Trp  *
285                 290                 295
 
gaagctggca gcgtaccccc cgcccgagtt ccagtggtac aaggatggaa aggcactgtc 973
cgggcgccac agtccacatg ccctggtgct caaggaggtg acagaggcca gcacaggcac 1033
ctacaccctc gccctgtgga actccgctgc tggcctgagg cgcaacatca gcctggagct 1093
ggtggtgaat gtgccccccc agatacatga gaaggaggcc tcctccccca gcatctactc 1153
gcgtcacagc cgccaggccc tcacctgcac ggcctacggg gtgcccctgc ctctcagcat 1213
ccagtggcac tggcggccct ggacaccctg caagatgttt gcccagcgta gtctccggcg 1273
gcggcagcag caagacctca tgccacagtg ccgtgactgg agggcggtga ccacgcagga 1333
tgccgtgaac cccatcgaga gcc                                         1356

<210> 286
<211> 295
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR007F05

<400> 286
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15      
Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30          
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45              
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60                  
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80  
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95      
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110         
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125             
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140                 
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160 
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175     
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190         
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205             
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220                 
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240 
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255     
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270         
Lys Ile Pro Ser Ser Ala Ser Ser Gly Ser Lys Asp Pro Ser Trp Arg
        275                 280                 285             
Pro Arg Gln Glu Thr Ser Trp
    290                 295 

<210> 287
<211> 2620
<212> DNA
<213> Homo Sapiens

<220> 
<223> SR015G09

<400> 287
gcagcggccg gagatgcagc ggggcgccgc gctgtgcctg cgactgtggc tctgcctggg 60
actcctggac ggcctggtga gtggctactc catgaccccc ccgaccttga acatcacgga 120
ggagtcacac gtcatcgaca ccggtgacag cctgtccatc tcctgcaggg gacagcaccc 180
cctcgagtgg gcttggccag gagctcagga ggcgccagcc accggagaca aggacagcga 240
ggacacgggg gtggtgcgag actgcgaggg cacagacgcc aggccctact gcaaggtgtt 300
gctgctgcac gaggtacatg ccaacgacac aggcagctac gtctgctact acaagtacat 360
caaggcacgc atcgagggca ccacggccgc cagctcctac gtgttcgtga gagactttga 420
gcagccattc atcaacaagc ctgacacgct cttggtcaac aggaaggacg ccatgtgggt 480
gccctgtctg gtgtccatcc ccggcctcaa tgtcacgctg cgctcgcaaa gctcggtgct 540
gtggccagac gggcaggagg tggtgtggga tgaccggcgg ggcatgctcg tgtccacgcc 600
actgctgcac gatgccctgt acctgcagtg cgagaccacc tggggagacc aggacttcct 660
ttccaacccc ttcctggtgc acatcacagg caacgagctc tatgacatcc agctgttgcc 720
caggaagtcg ctggagctgc tggtagggga gaagctggtc ctgaactgca ccgtgtgggc 780
tgagtttaac tcaggtgtca cctttgactg ggactaccca gggaagcagg cagagcgggg 840
taagtgggtg cccgagcgac gctcccagca gacccacaca gaactctcca gcatcctgac 900
catccacaac gtcagccagc acgacctggg ctcgtatgtg tgcaaggcca acaacggcat 960
ccagcgattt cgggagagca ccgaggtcat tgtgcatgaa aatcccttca tcagcgtcga 1020
gtggctcaaa ggacccatcc tggaggccac ggcaggagac gagctggtga agctgcccgt 1080
gaagctggca gcgtaccccc cgcccgagtt ccagtggtac aaggatggaa aggcactgtc 1140
cgggcgccac agtccacatg ccctggtgct caaggaggtg acagaggcca gcacaggcac 1200
ctacaccctc gccctgtgga actccgctgc tggcctgagg cgcaacatca gcctggagct 1260
ggtggtgaat gtgccccccc agatacatga gaaggaggcc tcctccccca gcatctactc 1320
gcgtcacagc cgccaggccc tcacctgcac ggcctacggg gtgcccctgc ctctcagcat 1380
ccagtggcac tggcggccct ggacaccctg caagatgttt gcccagcgta gtctccggcg 1440
gcggcagcag caagacctca tgccacagtg ccgtgactgg agggcggtga ccacgcagga 1500
tgccgtgaac cccatcgaga gcctggacac ctggaccgag tttgtggagg gaaagaataa 1560
gactgtgagc aagctggtga tccagaatgc caacgtgtct gccatgtaca agtgtgtggt 1620
ctccaacaag gtgggccagg atgagcggct catctacttc tatgtgacca ccatccccga 1680
cggcttcacc atcgaatcca agccatccga ggagctacta gagggccagc cggtgctcct 1740
gagctgccaa gccgacagct acaagtacga gcatctgcgc tggtaccgcc tcaacctgtc 1800
cacgctgcac gatgcgcacg ggaacccgct tctgctcgac tgcaagaacg tgcatctgtt 1860
cgccacccct ctggccgcca gcctggagga ggtggcacct ggggcgcgcc acgccacgct 1920
cagcctgagt atcccccgcg tcgcgcccga gcacgagggc cactatgtgt gcgaagtgca 1980
agaccggcgc agccatgaca agcactgcca caagaagtac ctgtcggtgc aggccctgga 2040
agcccctcgg ctcacgcaga acttgaccga cctcctggtg aacgtgagcg actcgctgga 2100
gatgcagtgc ttggtggccg gagcgcacgc gcccagcatc gtgtggtaca aagacgagag 2160
gctgctggag gaaaagtctg gtagggaggg tggccctggc gaagggcagg tccggaggcc 2220
cgcgaggccg acgatcccaa acccaggtgg acccgcacct ccaccccacc ccctgcagga 2280
gtcgacttgg cggactccaa ccagaagctg agcatccagc gcgtgcgcga ggaggatgcg 2340
ggacgctatc tgtgcagcgt gtgcaacgcc aagggctgcg tcaactcctc cgccagcgtg 2400
gccgtggaag gctccgagga taagggcagc atggagatcg tgatccttgt cggtaccggc 2460
gtcatcgctg tcttcttctg ggtcctcctc ctcctcatct tctgtaacat gaggaggccg 2520
gcccacgcag acatcaagac gggctacctg tccatcatca tggaccccgg ggaggtgcct 2580
ctggaggagc aatgcgaata cctgtcctac gatgccagcc                       2620

<210> 288
<211> 765
<212> PRT
<213> Homo Sapiens

<220> 
<223> SR015G09

<400> 288
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15      
Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30          
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45              
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60                  
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80  
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95      
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110         
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125             
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140                 
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160 
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175     
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190         
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205             
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220                 
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240 
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255     
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270         
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285             
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300                 
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320 
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335     
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350         
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365             
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380                 
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400 
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415     
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430         
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445             
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460                 
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480 
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495     
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510         
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525             
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540                 
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560 
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575     
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590         
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605             
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620                 
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640 
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655     
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670         
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685             
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700                 
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720 
Lys Ser Gly Arg Glu Gly Gly Pro Gly Glu Gly Gln Val Arg Arg Pro
                725                 730                 735     
Ala Arg Pro Thr Ile Pro Asn Pro Gly Gly Pro Ala Pro Pro Pro His
            740                 745                 750         
Pro Leu Gln Glu Ser Thr Trp Arg Thr Pro Thr Arg Ser
        755                 760                 765 


<210> 289
<211> 419
<212> PRT
<213> Homo sapiens

<220> 
<223> Herstatin

<400> 289
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val
            340                 345                 350         
Pro Val Pro Leu Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser
        355                 360                 365             
Phe Leu Arg Pro Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro
    370                 375                 380                 
Leu Ala Pro Leu Asp Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val
385                 390                 395                 400 
Gly Arg Gly Pro Ser Pro Asp Ala His Val Ala Val Asp Leu Ser Arg
                405                 410                 415     
Tyr Glu Gly
            
<210> 290
<211> 419
<212> PRT
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> VARIANT        
<222> 342
<223> Xaa= Thr or Ser

<400> 290
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Gly Xaa His Ser Leu Pro Pro Arg Pro Ala Ala Val
            340                 345                 350         
Pro Val Pro Leu Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser
        355                 360                 365             
Phe Leu Arg Pro Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro
    370                 375                 380                 
Leu Ala Pro Leu Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val
385                 390                 395                 400 
Gly Arg Gly Pro Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg
                405                 410                 415     
Tyr Glu Gly
          
<210> 291
<211> 419
<212> PRT
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> VARIANT        
<222> 345
<223> Xaa= Leu or Pro

<400> 291
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Gly Thr His Ser Xaa Pro Pro Arg Pro Ala Ala Val
            340                 345                 350         
Pro Val Pro Leu Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser
        355                 360                 365             
Phe Leu Arg Pro Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro
    370                 375                 380                 
Leu Ala Pro Leu Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val
385                 390                 395                 400 
Gly Arg Gly Pro Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg
                405                 410                 415     
Tyr Glu Gly
            
<210> 292
<211> 419
<212> PRT
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> VARIANT        
<222> 346
<223> Xaa= Pro or Leu

<400> 292
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Gly Thr His Ser Leu Xaa Pro Arg Pro Ala Ala Val
            340                 345                 350         
Pro Val Pro Leu Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser
        355                 360                 365             
Phe Leu Arg Pro Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro
    370                 375                 380                 
Leu Ala Pro Leu Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val
385                 390                 395                 400 
Gly Arg Gly Pro Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg
                405                 410                 415     
Tyr Glu Gly
            
<210> 293
<211> 419
<212> PRT
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> VARIANT        
<222> 356
<223> Xaa= Leu or Gln

<400> 293
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val
            340                 345                 350         
Pro Val Pro Xaa Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser
        355                 360                 365             
Phe Leu Arg Pro Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro
    370                 375                 380                 
Leu Ala Pro Leu Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val
385                 390                 395                 400 
Gly Arg Gly Pro Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg
                405                 410                 415     
Tyr Glu Gly
            
<210> 294
<211> 419
<212> PRT
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> VARIANT        
<222> 357
<223> Xaa= Arg or Cys

<400> 294
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val
            340                 345                 350         
Pro Val Pro Leu Xaa Met Gln Pro Gly Pro Ala His Pro Val Leu Ser
        355                 360                 365             
Phe Leu Arg Pro Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro
    370                 375                 380                 
Leu Ala Pro Leu Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val
385                 390                 395                 400 
Gly Arg Gly Pro Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg
                405                 410                 415     
Tyr Glu Gly


<210> 295
<211> 419
<212> PRT
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> VARIANT        
<222> 358
<223> Xaa= Met or Leu

<400> 295
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val
            340                 345                 350         
Pro Val Pro Leu Arg Xaa Gln Pro Gly Pro Ala His Pro Val Leu Ser
        355                 360                 365             
Phe Leu Arg Pro Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro
    370                 375                 380                 
Leu Ala Pro Leu Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val
385                 390                 395                 400 
Gly Arg Gly Pro Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg
                405                 410                 415     
Tyr Glu Gly
            

<210> 296
<211> 419
<212> PRT
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> VARIANT        
<222> 358
<223> Xaa= Met or Ile

<400> 296
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val
            340                 345                 350         
Pro Val Pro Leu Arg Xaa Gln Pro Gly Pro Ala His Pro Val Leu Ser
        355                 360                 365             
Phe Leu Arg Pro Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro
    370                 375                 380                 
Leu Ala Pro Leu Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val
385                 390                 395                 400 
Gly Arg Gly Pro Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg
                405                 410                 415     
Tyr Glu Gly
            

<210> 297
<211> 419
<212> PRT
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> VARIANT        
<222> 361
<223> Xaa= Gly, Asp, Ala, or Val

<400> 297
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val
            340                 345                 350         
Pro Val Pro Leu Arg Met Gln Pro Xaa Pro Ala His Pro Val Leu Ser
        355                 360                 365             
Phe Leu Arg Pro Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro
    370                 375                 380                 
Leu Ala Pro Leu Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val
385                 390                 395                 400 
Gly Arg Gly Pro Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg
                405                 410                 415     
Tyr Glu Gly
            

<210> 298
<211> 419
<212> PRT
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> VARIANT        
<222> 371
<223> Xaa= Arg or Ile

<400> 298
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val
            340                 345                 350         
Pro Val Pro Leu Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser
        355                 360                 365             
Phe Leu Xaa Pro Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro
    370                 375                 380                 
Leu Ala Pro Leu Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val
385                 390                 395                 400 
Gly Arg Gly Pro Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg
                405                 410                 415     
Tyr Glu Gly
       

<210> 299
<211> 419
<212> PRT
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> VARIANT        
<222> 376
<223> Xaa= Leu or Ile

<400> 299
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val
            340                 345                 350         
Pro Val Pro Leu Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser
        355                 360                 365             
Phe Leu Arg Pro Ser Trp Asp Xaa Val Ser Ala Phe Tyr Ser Leu Pro
    370                 375                 380                 
Leu Ala Pro Leu Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val
385                 390                 395                 400 
Gly Arg Gly Pro Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg
                405                 410                 415     
Tyr Glu Gly
            
<210> 300
<211> 419
<212> PRT
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> VARIANT        
<222> 394
<223> Xaa= Pro or Arg

<400> 300
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val
            340                 345                 350         
Pro Val Pro Leu Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser
        355                 360                 365             
Phe Leu Arg Pro Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro
    370                 375                 380                 
Leu Ala Pro Leu Ser Pro Thr Ser Val Xaa Ile Ser Pro Val Ser Val
385                 390                 395                 400 
Gly Arg Gly Pro Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg
                405                 410                 415     
Tyr Glu Gly
            
<210> 301
<211> 419
<212> PRT
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> VARIANT        
<222> 404
<223> Xaa= Pro or Leu

<400> 301
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val
            340                 345                 350         
Pro Val Pro Leu Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser
        355                 360                 365             
Phe Leu Arg Pro Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro
    370                 375                 380                 
Leu Ala Pro Leu Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val
385                 390                 395                 400 
Gly Arg Gly Xaa Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg
                405                 410                 415     
Tyr Glu Gly
         
<210> 302
<211> 419
<212> PRT
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> VARIANT        
<222> 413
<223> Xaa= Asp, Asn, or His

<400> 302
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val
            340                 345                 350         
Pro Val Pro Leu Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser
        355                 360                 365             
Phe Leu Arg Pro Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro
    370                 375                 380                 
Leu Ala Pro Leu Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val
385                 390                 395                 400 
Gly Arg Gly Pro Asp Pro Asp Ala His Val Ala Val Xaa Leu Ser Arg
                405                 410                 415     
Tyr Glu Gly
            
            
<210> 303
<211> 419
<212> PRT
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> VARIANT        
<222> 346
<223> Xaa= Pro or Leu

<220> 
<221> VARIANT        
<222> 413
<223> Xaa= Asp, His, or Asn

<400> 303
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Gly Thr His Ser Leu Xaa Pro Arg Pro Ala Ala Val
            340                 345                 350         
Pro Val Pro Leu Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser
        355                 360                 365             
Phe Leu Arg Pro Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro
    370                 375                 380                 
Leu Ala Pro Leu Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val
385                 390                 395                 400 
Gly Arg Gly Pro Asp Pro Asp Ala His Val Ala Val Xaa Leu Ser Arg
                405                 410                 415     
Tyr Glu Gly
            

<210> 304
<211> 1316
<212> DNA
<213> Homo sapiens

<220> 
<223> Herstatin

<400> 304
gcagtgagca ccatggagct ggcggccttg tgccgctggg ggctcctcct cgccctcttg 60
ccccccggag ccgcgagcac ccaagtgtgc accggcacag acatgaagct gcggctccct 120
gccagtcccg agacccacct ggacatgctc cgccacctct accagggatg ccaggtggtg 180
cagggaaacc tggaactcac ctacctgccc accaatgcca gcctgtcctt cctgcaggat 240
atccaggagg tgcagggcta cgtgctcatc gctcacaacc aagtgaggca ggtcccactg 300
cagaggctgc ggattgtgcg aggcacccag ctctttgagg acaactatgc cctggccgtg 360
ctagacaatg gagacccgct gaacaatacc acccctgtca caggggcctc cccaggaggc 420
ctgcgggagc tgcagcttcg aagcctcaca gagatcttga aaggaggggt cttgatccag 480
cggaaccccc agctctgcta ccaggacacg attttgtgga aggacatctt ccacaagaac 540
aaccagctgg ctctcacact gatagacacc aaccgctctc gggcctgcca cccctgctct 600
ccgatgtgta agggctcccg ctgctgggga gagagttctg aggattgtca gagcctgacg 660
cgcactgtct gtgccggtgg ctgtgcccgc tgcaaggggc cactgcccac tgactgctgc 720
catgagcagt gtgctgccgg ctgcacgggc cccaagcact ctgactgcct ggcctgcctc 780
cacttcaacc acagtggcat ctgtgagctg cactgcccag ccctggtcac ctacaacaca 840
gacacgtttg agtccatgcc caatcccgag ggccggtata cattcggcgc cagctgtgtc 900
actgcctgtc cctacaacta cctttctacg gacgtgggat cctgcaccct cgtctgcccc 960
ctgcacaacc aagaggtgac agcagaggat ggaacacagc ggtgtgagaa gtgcagcaag 1020
ccctgtgccc gaggtaccca ctcactgccc ccgaggccag ctgcagttcc tgtccctctg 1080
cgcatgcagc ctggcccagc ccaccctgtc ctatccttcc tcagaccctc ttgggaccta 1140
gtctctgcct tctactctct acccctggcc cccctcagcc ctacaagtgt ccctatatcc 1200
cctgtcagtg tggggagggg cccggaccct gatgctcatg tggctgttga cctgtcccgg 1260
tatgaaggct gagacggccc cttccccacc cacccccacc tcctcagtgt gctatg     1316

<210> 305
<211> 1316
<212> DNA
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> allele
<222> 1036
<223> n= A or T 

<400> 305
gcagtgagca ccatggagct ggcggccttg tgccgctggg ggctcctcct cgccctcttg 60
ccccccggag ccgcgagcac ccaagtgtgc accggcacag acatgaagct gcggctccct 120
gccagtcccg agacccacct ggacatgctc cgccacctct accagggatg ccaggtggtg 180
cagggaaacc tggaactcac ctacctgccc accaatgcca gcctgtcctt cctgcaggat 240
atccaggagg tgcagggcta cgtgctcatc gctcacaacc aagtgaggca ggtcccactg 300
cagaggctgc ggattgtgcg aggcacccag ctctttgagg acaactatgc cctggccgtg 360
ctagacaatg gagacccgct gaacaatacc acccctgtca caggggcctc cccaggaggc 420
ctgcgggagc tgcagcttcg aagcctcaca gagatcttga aaggaggggt cttgatccag 480
cggaaccccc agctctgcta ccaggacacg attttgtgga aggacatctt ccacaagaac 540
aaccagctgg ctctcacact gatagacacc aaccgctctc gggcctgcca cccctgctct 600
ccgatgtgta agggctcccg ctgctgggga gagagttctg aggattgtca gagcctgacg 660
cgcactgtct gtgccggtgg ctgtgcccgc tgcaaggggc cactgcccac tgactgctgc 720
catgagcagt gtgctgccgg ctgcacgggc cccaagcact ctgactgcct ggcctgcctc 780
cacttcaacc acagtggcat ctgtgagctg cactgcccag ccctggtcac ctacaacaca 840
gacacgtttg agtccatgcc caatcccgag ggccggtata cattcggcgc cagctgtgtc 900
actgcctgtc cctacaacta cctttctacg gacgtgggat cctgcaccct cgtctgcccc 960
ctgcacaacc aagaggtgac agcagaggat ggaacacagc ggtgtgagaa gtgcagcaag 1020
ccctgtgccc gaggtnccca ctcactgccc ccgaggccag ctgcagttcc tgtccctctg 1080
cgcatgcagc ctggcccagc ccaccctgtc ctatccttcc tcagaccctc ttgggaccta 1140
gtctctgcct tctactctct acccctggcc cccctcagcc ctacaagtgt ccctatatcc 1200
cctgtcagtg tggggagggg cccggaccct gatgctcatg tggctgttga cctgtcccgg 1260
tatgaaggct gagacggccc cttccccacc cacccccacc tcctcagtgt gctatg     1316

<210> 306
<211> 1316
<212> DNA
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> allele
<222> 1046
<223> n= T or C

<400> 306
gcagtgagca ccatggagct ggcggccttg tgccgctggg ggctcctcct cgccctcttg 60
ccccccggag ccgcgagcac ccaagtgtgc accggcacag acatgaagct gcggctccct 120
gccagtcccg agacccacct ggacatgctc cgccacctct accagggatg ccaggtggtg 180
cagggaaacc tggaactcac ctacctgccc accaatgcca gcctgtcctt cctgcaggat 240
atccaggagg tgcagggcta cgtgctcatc gctcacaacc aagtgaggca ggtcccactg 300
cagaggctgc ggattgtgcg aggcacccag ctctttgagg acaactatgc cctggccgtg 360
ctagacaatg gagacccgct gaacaatacc acccctgtca caggggcctc cccaggaggc 420
ctgcgggagc tgcagcttcg aagcctcaca gagatcttga aaggaggggt cttgatccag 480
cggaaccccc agctctgcta ccaggacacg attttgtgga aggacatctt ccacaagaac 540
aaccagctgg ctctcacact gatagacacc aaccgctctc gggcctgcca cccctgctct 600
ccgatgtgta agggctcccg ctgctgggga gagagttctg aggattgtca gagcctgacg 660
cgcactgtct gtgccggtgg ctgtgcccgc tgcaaggggc cactgcccac tgactgctgc 720
catgagcagt gtgctgccgg ctgcacgggc cccaagcact ctgactgcct ggcctgcctc 780
cacttcaacc acagtggcat ctgtgagctg cactgcccag ccctggtcac ctacaacaca 840
gacacgtttg agtccatgcc caatcccgag ggccggtata cattcggcgc cagctgtgtc 900
actgcctgtc cctacaacta cctttctacg gacgtgggat cctgcaccct cgtctgcccc 960
ctgcacaacc aagaggtgac agcagaggat ggaacacagc ggtgtgagaa gtgcagcaag 1020
ccctgtgccc gaggtaccca ctcacngccc ccgaggccag ctgcagttcc tgtccctctg 1080
cgcatgcagc ctggcccagc ccaccctgtc ctatccttcc tcagaccctc ttgggaccta 1140
gtctctgcct tctactctct acccctggcc cccctcagcc ctacaagtgt ccctatatcc 1200
cctgtcagtg tggggagggg cccggaccct gatgctcatg tggctgttga cctgtcccgg 1260
tatgaaggct gagacggccc cttccccacc cacccccacc tcctcagtgt gctatg     1316

<210> 307
<211> 1316
<212> DNA
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> allele
<222> 1049
<223> n= C or T

<400> 307
gcagtgagca ccatggagct ggcggccttg tgccgctggg ggctcctcct cgccctcttg 60
ccccccggag ccgcgagcac ccaagtgtgc accggcacag acatgaagct gcggctccct 120
gccagtcccg agacccacct ggacatgctc cgccacctct accagggatg ccaggtggtg 180
cagggaaacc tggaactcac ctacctgccc accaatgcca gcctgtcctt cctgcaggat 240
atccaggagg tgcagggcta cgtgctcatc gctcacaacc aagtgaggca ggtcccactg 300
cagaggctgc ggattgtgcg aggcacccag ctctttgagg acaactatgc cctggccgtg 360
ctagacaatg gagacccgct gaacaatacc acccctgtca caggggcctc cccaggaggc 420
ctgcgggagc tgcagcttcg aagcctcaca gagatcttga aaggaggggt cttgatccag 480
cggaaccccc agctctgcta ccaggacacg attttgtgga aggacatctt ccacaagaac 540
aaccagctgg ctctcacact gatagacacc aaccgctctc gggcctgcca cccctgctct 600
ccgatgtgta agggctcccg ctgctgggga gagagttctg aggattgtca gagcctgacg 660
cgcactgtct gtgccggtgg ctgtgcccgc tgcaaggggc cactgcccac tgactgctgc 720
catgagcagt gtgctgccgg ctgcacgggc cccaagcact ctgactgcct ggcctgcctc 780
cacttcaacc acagtggcat ctgtgagctg cactgcccag ccctggtcac ctacaacaca 840
gacacgtttg agtccatgcc caatcccgag ggccggtata cattcggcgc cagctgtgtc 900
actgcctgtc cctacaacta cctttctacg gacgtgggat cctgcaccct cgtctgcccc 960
ctgcacaacc aagaggtgac agcagaggat ggaacacagc ggtgtgagaa gtgcagcaag 1020
ccctgtgccc gaggtaccca ctcactgcnc ccgaggccag ctgcagttcc tgtccctctg 1080
cgcatgcagc ctggcccagc ccaccctgtc ctatccttcc tcagaccctc ttgggaccta 1140
gtctctgcct tctactctct acccctggcc cccctcagcc ctacaagtgt ccctatatcc 1200
cctgtcagtg tggggagggg cccggaccct gatgctcatg tggctgttga cctgtcccgg 1260
tatgaaggct gagacggccc cttccccacc cacccccacc tcctcagtgt gctatg     1316


<210> 308
<211> 1316
<212> DNA
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> allele
<222> 1079
<223> n= T or A

<400> 308
gcagtgagca ccatggagct ggcggccttg tgccgctggg ggctcctcct cgccctcttg 60
ccccccggag ccgcgagcac ccaagtgtgc accggcacag acatgaagct gcggctccct 120
gccagtcccg agacccacct ggacatgctc cgccacctct accagggatg ccaggtggtg 180
cagggaaacc tggaactcac ctacctgccc accaatgcca gcctgtcctt cctgcaggat 240
atccaggagg tgcagggcta cgtgctcatc gctcacaacc aagtgaggca ggtcccactg 300
cagaggctgc ggattgtgcg aggcacccag ctctttgagg acaactatgc cctggccgtg 360
ctagacaatg gagacccgct gaacaatacc acccctgtca caggggcctc cccaggaggc 420
ctgcgggagc tgcagcttcg aagcctcaca gagatcttga aaggaggggt cttgatccag 480
cggaaccccc agctctgcta ccaggacacg attttgtgga aggacatctt ccacaagaac 540
aaccagctgg ctctcacact gatagacacc aaccgctctc gggcctgcca cccctgctct 600
ccgatgtgta agggctcccg ctgctgggga gagagttctg aggattgtca gagcctgacg 660
cgcactgtct gtgccggtgg ctgtgcccgc tgcaaggggc cactgcccac tgactgctgc 720
catgagcagt gtgctgccgg ctgcacgggc cccaagcact ctgactgcct ggcctgcctc 780
cacttcaacc acagtggcat ctgtgagctg cactgcccag ccctggtcac ctacaacaca 840
gacacgtttg agtccatgcc caatcccgag ggccggtata cattcggcgc cagctgtgtc 900
actgcctgtc cctacaacta cctttctacg gacgtgggat cctgcaccct cgtctgcccc 960
ctgcacaacc aagaggtgac agcagaggat ggaacacagc ggtgtgagaa gtgcagcaag 1020
ccctgtgccc gaggtaccca ctcactgccc ccgaggccag ctgcagttcc tgtccctcng 1080
cgcatgcagc ctggcccagc ccaccctgtc ctatccttcc tcagaccctc ttgggaccta 1140
gtctctgcct tctactctct acccctggcc cccctcagcc ctacaagtgt ccctatatcc 1200
cctgtcagtg tggggagggg cccggaccct gatgctcatg tggctgttga cctgtcccgg 1260
tatgaaggct gagacggccc cttccccacc cacccccacc tcctcagtgt gctatg     1316

<210> 309
<211> 1316
<212> DNA
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> allele
<222> 1081
<223> n= C or T

<400> 309
gcagtgagca ccatggagct ggcggccttg tgccgctggg ggctcctcct cgccctcttg 60
ccccccggag ccgcgagcac ccaagtgtgc accggcacag acatgaagct gcggctccct 120
gccagtcccg agacccacct ggacatgctc cgccacctct accagggatg ccaggtggtg 180
cagggaaacc tggaactcac ctacctgccc accaatgcca gcctgtcctt cctgcaggat 240
atccaggagg tgcagggcta cgtgctcatc gctcacaacc aagtgaggca ggtcccactg 300
cagaggctgc ggattgtgcg aggcacccag ctctttgagg acaactatgc cctggccgtg 360
ctagacaatg gagacccgct gaacaatacc acccctgtca caggggcctc cccaggaggc 420
ctgcgggagc tgcagcttcg aagcctcaca gagatcttga aaggaggggt cttgatccag 480
cggaaccccc agctctgcta ccaggacacg attttgtgga aggacatctt ccacaagaac 540
aaccagctgg ctctcacact gatagacacc aaccgctctc gggcctgcca cccctgctct 600
ccgatgtgta agggctcccg ctgctgggga gagagttctg aggattgtca gagcctgacg 660
cgcactgtct gtgccggtgg ctgtgcccgc tgcaaggggc cactgcccac tgactgctgc 720
catgagcagt gtgctgccgg ctgcacgggc cccaagcact ctgactgcct ggcctgcctc 780
cacttcaacc acagtggcat ctgtgagctg cactgcccag ccctggtcac ctacaacaca 840
gacacgtttg agtccatgcc caatcccgag ggccggtata cattcggcgc cagctgtgtc 900
actgcctgtc cctacaacta cctttctacg gacgtgggat cctgcaccct cgtctgcccc 960
ctgcacaacc aagaggtgac agcagaggat ggaacacagc ggtgtgagaa gtgcagcaag 1020
ccctgtgccc gaggtaccca ctcactgccc ccgaggccag ctgcagttcc tgtccctctg 1080
ngcatgcagc ctggcccagc ccaccctgtc ctatccttcc tcagaccctc ttgggaccta 1140
gtctctgcct tctactctct acccctggcc cccctcagcc ctacaagtgt ccctatatcc 1200
cctgtcagtg tggggagggg cccggaccct gatgctcatg tggctgttga cctgtcccgg 1260
tatgaaggct gagacggccc cttccccacc cacccccacc tcctcagtgt gctatg     1316

<210> 310
<211> 1316
<212> DNA
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> allele
<222> 1084
<223> n= A or C

<400> 310
gcagtgagca ccatggagct ggcggccttg tgccgctggg ggctcctcct cgccctcttg 60
ccccccggag ccgcgagcac ccaagtgtgc accggcacag acatgaagct gcggctccct 120
gccagtcccg agacccacct ggacatgctc cgccacctct accagggatg ccaggtggtg 180
cagggaaacc tggaactcac ctacctgccc accaatgcca gcctgtcctt cctgcaggat 240
atccaggagg tgcagggcta cgtgctcatc gctcacaacc aagtgaggca ggtcccactg 300
cagaggctgc ggattgtgcg aggcacccag ctctttgagg acaactatgc cctggccgtg 360
ctagacaatg gagacccgct gaacaatacc acccctgtca caggggcctc cccaggaggc 420
ctgcgggagc tgcagcttcg aagcctcaca gagatcttga aaggaggggt cttgatccag 480
cggaaccccc agctctgcta ccaggacacg attttgtgga aggacatctt ccacaagaac 540
aaccagctgg ctctcacact gatagacacc aaccgctctc gggcctgcca cccctgctct 600
ccgatgtgta agggctcccg ctgctgggga gagagttctg aggattgtca gagcctgacg 660
cgcactgtct gtgccggtgg ctgtgcccgc tgcaaggggc cactgcccac tgactgctgc 720
catgagcagt gtgctgccgg ctgcacgggc cccaagcact ctgactgcct ggcctgcctc 780
cacttcaacc acagtggcat ctgtgagctg cactgcccag ccctggtcac ctacaacaca 840
gacacgtttg agtccatgcc caatcccgag ggccggtata cattcggcgc cagctgtgtc 900
actgcctgtc cctacaacta cctttctacg gacgtgggat cctgcaccct cgtctgcccc 960
ctgcacaacc aagaggtgac agcagaggat ggaacacagc ggtgtgagaa gtgcagcaag 1020
ccctgtgccc gaggtaccca ctcactgccc ccgaggccag ctgcagttcc tgtccctctg 1080
cgcntgcagc ctggcccagc ccaccctgtc ctatccttcc tcagaccctc ttgggaccta 1140
gtctctgcct tctactctct acccctggcc cccctcagcc ctacaagtgt ccctatatcc 1200
cctgtcagtg tggggagggg cccggaccct gatgctcatg tggctgttga cctgtcccgg 1260
tatgaaggct gagacggccc cttccccacc cacccccacc tcctcagtgt gctatg     1316


<210> 311
<211> 1316
<212> DNA
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> allele
<222> 1086
<223> n= G or A

<400> 311
gcagtgagca ccatggagct ggcggccttg tgccgctggg ggctcctcct cgccctcttg 60
ccccccggag ccgcgagcac ccaagtgtgc accggcacag acatgaagct gcggctccct 120
gccagtcccg agacccacct ggacatgctc cgccacctct accagggatg ccaggtggtg 180
cagggaaacc tggaactcac ctacctgccc accaatgcca gcctgtcctt cctgcaggat 240
atccaggagg tgcagggcta cgtgctcatc gctcacaacc aagtgaggca ggtcccactg 300
cagaggctgc ggattgtgcg aggcacccag ctctttgagg acaactatgc cctggccgtg 360
ctagacaatg gagacccgct gaacaatacc acccctgtca caggggcctc cccaggaggc 420
ctgcgggagc tgcagcttcg aagcctcaca gagatcttga aaggaggggt cttgatccag 480
cggaaccccc agctctgcta ccaggacacg attttgtgga aggacatctt ccacaagaac 540
aaccagctgg ctctcacact gatagacacc aaccgctctc gggcctgcca cccctgctct 600
ccgatgtgta agggctcccg ctgctgggga gagagttctg aggattgtca gagcctgacg 660
cgcactgtct gtgccggtgg ctgtgcccgc tgcaaggggc cactgcccac tgactgctgc 720
catgagcagt gtgctgccgg ctgcacgggc cccaagcact ctgactgcct ggcctgcctc 780
cacttcaacc acagtggcat ctgtgagctg cactgcccag ccctggtcac ctacaacaca 840
gacacgtttg agtccatgcc caatcccgag ggccggtata cattcggcgc cagctgtgtc 900
actgcctgtc cctacaacta cctttctacg gacgtgggat cctgcaccct cgtctgcccc 960
ctgcacaacc aagaggtgac agcagaggat ggaacacagc ggtgtgagaa gtgcagcaag 1020
ccctgtgccc gaggtaccca ctcactgccc ccgaggccag ctgcagttcc tgtccctctg 1080
cgcatncagc ctggcccagc ccaccctgtc ctatccttcc tcagaccctc ttgggaccta 1140
gtctctgcct tctactctct acccctggcc cccctcagcc ctacaagtgt ccctatatcc 1200
cctgtcagtg tggggagggg cccggaccct gatgctcatg tggctgttga cctgtcccgg 1260
tatgaaggct gagacggccc cttccccacc cacccccacc tcctcagtgt gctatg     1316

<210> 312
<211> 1316
<212> DNA
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> allele
<222> 1094
<223> n= G, C, T, or A

<400> 312
gcagtgagca ccatggagct ggcggccttg tgccgctggg ggctcctcct cgccctcttg 60
ccccccggag ccgcgagcac ccaagtgtgc accggcacag acatgaagct gcggctccct 120
gccagtcccg agacccacct ggacatgctc cgccacctct accagggatg ccaggtggtg 180
cagggaaacc tggaactcac ctacctgccc accaatgcca gcctgtcctt cctgcaggat 240
atccaggagg tgcagggcta cgtgctcatc gctcacaacc aagtgaggca ggtcccactg 300
cagaggctgc ggattgtgcg aggcacccag ctctttgagg acaactatgc cctggccgtg 360
ctagacaatg gagacccgct gaacaatacc acccctgtca caggggcctc cccaggaggc 420
ctgcgggagc tgcagcttcg aagcctcaca gagatcttga aaggaggggt cttgatccag 480
cggaaccccc agctctgcta ccaggacacg attttgtgga aggacatctt ccacaagaac 540
aaccagctgg ctctcacact gatagacacc aaccgctctc gggcctgcca cccctgctct 600
ccgatgtgta agggctcccg ctgctgggga gagagttctg aggattgtca gagcctgacg 660
cgcactgtct gtgccggtgg ctgtgcccgc tgcaaggggc cactgcccac tgactgctgc 720
catgagcagt gtgctgccgg ctgcacgggc cccaagcact ctgactgcct ggcctgcctc 780
cacttcaacc acagtggcat ctgtgagctg cactgcccag ccctggtcac ctacaacaca 840
gacacgtttg agtccatgcc caatcccgag ggccggtata cattcggcgc cagctgtgtc 900
actgcctgtc cctacaacta cctttctacg gacgtgggat cctgcaccct cgtctgcccc 960
ctgcacaacc aagaggtgac agcagaggat ggaacacagc ggtgtgagaa gtgcagcaag 1020
ccctgtgccc gaggtaccca ctcactgccc ccgaggccag ctgcagttcc tgtccctctg 1080
cgcatgcagc ctgncccagc ccaccctgtc ctatccttcc tcagaccctc ttgggaccta 1140
gtctctgcct tctactctct acccctggcc cccctcagcc ctacaagtgt ccctatatcc 1200
cctgtcagtg tggggagggg cccggaccct gatgctcatg tggctgttga cctgtcccgg 1260
tatgaaggct gagacggccc cttccccacc cacccccacc tcctcagtgt gctatg     1316

<210> 313
<211> 1316
<212> DNA
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> allele
<222> 1124
<223> n= G or T

<400> 313
gcagtgagca ccatggagct ggcggccttg tgccgctggg ggctcctcct cgccctcttg 60
ccccccggag ccgcgagcac ccaagtgtgc accggcacag acatgaagct gcggctccct 120
gccagtcccg agacccacct ggacatgctc cgccacctct accagggatg ccaggtggtg 180
cagggaaacc tggaactcac ctacctgccc accaatgcca gcctgtcctt cctgcaggat 240
atccaggagg tgcagggcta cgtgctcatc gctcacaacc aagtgaggca ggtcccactg 300
cagaggctgc ggattgtgcg aggcacccag ctctttgagg acaactatgc cctggccgtg 360
ctagacaatg gagacccgct gaacaatacc acccctgtca caggggcctc cccaggaggc 420
ctgcgggagc tgcagcttcg aagcctcaca gagatcttga aaggaggggt cttgatccag 480
cggaaccccc agctctgcta ccaggacacg attttgtgga aggacatctt ccacaagaac 540
aaccagctgg ctctcacact gatagacacc aaccgctctc gggcctgcca cccctgctct 600
ccgatgtgta agggctcccg ctgctgggga gagagttctg aggattgtca gagcctgacg 660
cgcactgtct gtgccggtgg ctgtgcccgc tgcaaggggc cactgcccac tgactgctgc 720
catgagcagt gtgctgccgg ctgcacgggc cccaagcact ctgactgcct ggcctgcctc 780
cacttcaacc acagtggcat ctgtgagctg cactgcccag ccctggtcac ctacaacaca 840
gacacgtttg agtccatgcc caatcccgag ggccggtata cattcggcgc cagctgtgtc 900
actgcctgtc cctacaacta cctttctacg gacgtgggat cctgcaccct cgtctgcccc 960
ctgcacaacc aagaggtgac agcagaggat ggaacacagc ggtgtgagaa gtgcagcaag 1020
ccctgtgccc gaggtaccca ctcactgccc ccgaggccag ctgcagttcc tgtccctctg 1080
cgcatgcagc ctggcccagc ccaccctgtc ctatccttcc tcanaccctc ttgggaccta 1140
gtctctgcct tctactctct acccctggcc cccctcagcc ctacaagtgt ccctatatcc 1200
cctgtcagtg tggggagggg cccggaccct gatgctcatg tggctgttga cctgtcccgg 1260
tatgaaggct gagacggccc cttccccacc cacccccacc tcctcagtgt gctatg     1316

<210> 314
<211> 1316
<212> DNA
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> allele
<222> 1138
<223> n= C or A

<400> 314
gcagtgagca ccatggagct ggcggccttg tgccgctggg ggctcctcct cgccctcttg 60
ccccccggag ccgcgagcac ccaagtgtgc accggcacag acatgaagct gcggctccct 120
gccagtcccg agacccacct ggacatgctc cgccacctct accagggatg ccaggtggtg 180
cagggaaacc tggaactcac ctacctgccc accaatgcca gcctgtcctt cctgcaggat 240
atccaggagg tgcagggcta cgtgctcatc gctcacaacc aagtgaggca ggtcccactg 300
cagaggctgc ggattgtgcg aggcacccag ctctttgagg acaactatgc cctggccgtg 360
ctagacaatg gagacccgct gaacaatacc acccctgtca caggggcctc cccaggaggc 420
ctgcgggagc tgcagcttcg aagcctcaca gagatcttga aaggaggggt cttgatccag 480
cggaaccccc agctctgcta ccaggacacg attttgtgga aggacatctt ccacaagaac 540
aaccagctgg ctctcacact gatagacacc aaccgctctc gggcctgcca cccctgctct 600
ccgatgtgta agggctcccg ctgctgggga gagagttctg aggattgtca gagcctgacg 660
cgcactgtct gtgccggtgg ctgtgcccgc tgcaaggggc cactgcccac tgactgctgc 720
catgagcagt gtgctgccgg ctgcacgggc cccaagcact ctgactgcct ggcctgcctc 780
cacttcaacc acagtggcat ctgtgagctg cactgcccag ccctggtcac ctacaacaca 840
gacacgtttg agtccatgcc caatcccgag ggccggtata cattcggcgc cagctgtgtc 900
actgcctgtc cctacaacta cctttctacg gacgtgggat cctgcaccct cgtctgcccc 960
ctgcacaacc aagaggtgac agcagaggat ggaacacagc ggtgtgagaa gtgcagcaag 1020
ccctgtgccc gaggtaccca ctcactgccc ccgaggccag ctgcagttcc tgtccctctg 1080
cgcatgcagc ctggcccagc ccaccctgtc ctatccttcc tcagaccctc ttgggacnta 1140
gtctctgcct tctactctct acccctggcc cccctcagcc ctacaagtgt ccctatatcc 1200
cctgtcagtg tggggagggg cccggaccct gatgctcatg tggctgttga cctgtcccgg 1260
tatgaaggct gagacggccc cttccccacc cacccccacc tcctcagtgt gctatg     1316

<210> 315
<211> 1316
<212> DNA
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> allele
<222> 1193
<223> n= C or G

<400> 315
gcagtgagca ccatggagct ggcggccttg tgccgctggg ggctcctcct cgccctcttg 60
ccccccggag ccgcgagcac ccaagtgtgc accggcacag acatgaagct gcggctccct 120
gccagtcccg agacccacct ggacatgctc cgccacctct accagggatg ccaggtggtg 180
cagggaaacc tggaactcac ctacctgccc accaatgcca gcctgtcctt cctgcaggat 240
atccaggagg tgcagggcta cgtgctcatc gctcacaacc aagtgaggca ggtcccactg 300
cagaggctgc ggattgtgcg aggcacccag ctctttgagg acaactatgc cctggccgtg 360
ctagacaatg gagacccgct gaacaatacc acccctgtca caggggcctc cccaggaggc 420
ctgcgggagc tgcagcttcg aagcctcaca gagatcttga aaggaggggt cttgatccag 480
cggaaccccc agctctgcta ccaggacacg attttgtgga aggacatctt ccacaagaac 540
aaccagctgg ctctcacact gatagacacc aaccgctctc gggcctgcca cccctgctct 600
ccgatgtgta agggctcccg ctgctgggga gagagttctg aggattgtca gagcctgacg 660
cgcactgtct gtgccggtgg ctgtgcccgc tgcaaggggc cactgcccac tgactgctgc 720
catgagcagt gtgctgccgg ctgcacgggc cccaagcact ctgactgcct ggcctgcctc 780
cacttcaacc acagtggcat ctgtgagctg cactgcccag ccctggtcac ctacaacaca 840
gacacgtttg agtccatgcc caatcccgag ggccggtata cattcggcgc cagctgtgtc 900
actgcctgtc cctacaacta cctttctacg gacgtgggat cctgcaccct cgtctgcccc 960
ctgcacaacc aagaggtgac agcagaggat ggaacacagc ggtgtgagaa gtgcagcaag 1020
ccctgtgccc gaggtaccca ctcactgccc ccgaggccag ctgcagttcc tgtccctctg 1080
cgcatgcagc ctggcccagc ccaccctgtc ctatccttcc tcagaccctc ttgggaccta 1140
gtctctgcct tctactctct acccctggcc cccctcagcc ctacaagtgt ccntatatcc 1200
cctgtcagtg tggggagggg cccggaccct gatgctcatg tggctgttga cctgtcccgg 1260
tatgaaggct gagacggccc cttccccacc cacccccacc tcctcagtgt gctatg     1316

<210> 316
<211> 1316
<212> DNA
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> allele
<222> 1223
<223> n= C or T

<400> 316
gcagtgagca ccatggagct ggcggccttg tgccgctggg ggctcctcct cgccctcttg 60
ccccccggag ccgcgagcac ccaagtgtgc accggcacag acatgaagct gcggctccct 120
gccagtcccg agacccacct ggacatgctc cgccacctct accagggatg ccaggtggtg 180
cagggaaacc tggaactcac ctacctgccc accaatgcca gcctgtcctt cctgcaggat 240
atccaggagg tgcagggcta cgtgctcatc gctcacaacc aagtgaggca ggtcccactg 300
cagaggctgc ggattgtgcg aggcacccag ctctttgagg acaactatgc cctggccgtg 360
ctagacaatg gagacccgct gaacaatacc acccctgtca caggggcctc cccaggaggc 420
ctgcgggagc tgcagcttcg aagcctcaca gagatcttga aaggaggggt cttgatccag 480
cggaaccccc agctctgcta ccaggacacg attttgtgga aggacatctt ccacaagaac 540
aaccagctgg ctctcacact gatagacacc aaccgctctc gggcctgcca cccctgctct 600
ccgatgtgta agggctcccg ctgctgggga gagagttctg aggattgtca gagcctgacg 660
cgcactgtct gtgccggtgg ctgtgcccgc tgcaaggggc cactgcccac tgactgctgc 720
catgagcagt gtgctgccgg ctgcacgggc cccaagcact ctgactgcct ggcctgcctc 780
cacttcaacc acagtggcat ctgtgagctg cactgcccag ccctggtcac ctacaacaca 840
gacacgtttg agtccatgcc caatcccgag ggccggtata cattcggcgc cagctgtgtc 900
actgcctgtc cctacaacta cctttctacg gacgtgggat cctgcaccct cgtctgcccc 960
ctgcacaacc aagaggtgac agcagaggat ggaacacagc ggtgtgagaa gtgcagcaag 1020
ccctgtgccc gaggtaccca ctcactgccc ccgaggccag ctgcagttcc tgtccctctg 1080
cgcatgcagc ctggcccagc ccaccctgtc ctatccttcc tcagaccctc ttgggaccta 1140
gtctctgcct tctactctct acccctggcc cccctcagcc ctacaagtgt ccctatatcc 1200
cctgtcagtg tggggagggg ccnggaccct gatgctcatg tggctgttga cctgtcccgg 1260
tatgaaggct gagacggccc cttccccacc cacccccacc tcctcagtgt gctatg     1316

<210> 317
<211> 1316
<212> DNA
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> allele
<222> 1249
<223> n= G, C, or A

<400> 317
gcagtgagca ccatggagct ggcggccttg tgccgctggg ggctcctcct cgccctcttg 60
ccccccggag ccgcgagcac ccaagtgtgc accggcacag acatgaagct gcggctccct 120
gccagtcccg agacccacct ggacatgctc cgccacctct accagggatg ccaggtggtg 180
cagggaaacc tggaactcac ctacctgccc accaatgcca gcctgtcctt cctgcaggat 240
atccaggagg tgcagggcta cgtgctcatc gctcacaacc aagtgaggca ggtcccactg 300
cagaggctgc ggattgtgcg aggcacccag ctctttgagg acaactatgc cctggccgtg 360
ctagacaatg gagacccgct gaacaatacc acccctgtca caggggcctc cccaggaggc 420
ctgcgggagc tgcagcttcg aagcctcaca gagatcttga aaggaggggt cttgatccag 480
cggaaccccc agctctgcta ccaggacacg attttgtgga aggacatctt ccacaagaac 540
aaccagctgg ctctcacact gatagacacc aaccgctctc gggcctgcca cccctgctct 600
ccgatgtgta agggctcccg ctgctgggga gagagttctg aggattgtca gagcctgacg 660
cgcactgtct gtgccggtgg ctgtgcccgc tgcaaggggc cactgcccac tgactgctgc 720
catgagcagt gtgctgccgg ctgcacgggc cccaagcact ctgactgcct ggcctgcctc 780
cacttcaacc acagtggcat ctgtgagctg cactgcccag ccctggtcac ctacaacaca 840
gacacgtttg agtccatgcc caatcccgag ggccggtata cattcggcgc cagctgtgtc 900
actgcctgtc cctacaacta cctttctacg gacgtgggat cctgcaccct cgtctgcccc 960
ctgcacaacc aagaggtgac agcagaggat ggaacacagc ggtgtgagaa gtgcagcaag 1020
ccctgtgccc gaggtaccca ctcactgccc ccgaggccag ctgcagttcc tgtccctctg 1080
cgcatgcagc ctggcccagc ccaccctgtc ctatccttcc tcagaccctc ttgggaccta 1140
gtctctgcct tctactctct acccctggcc cccctcagcc ctacaagtgt ccctatatcc 1200
cctgtcagtg tggggagggg cccggaccct gatgctcatg tggctgttna cctgtcccgg 1260
tatgaaggct gagacggccc cttccccacc cacccccacc tcctcagtgt gctatg     1316

<210> 318
<211> 1316
<212> DNA
<213> Homo sapiens

<220> 
<223> Herstatin variant

<220> 
<221> allele
<222> 1049
<223> n= C or T

<220> 
<221> allele
<222> 1249
<223> n= G, C, or A

<400> 318
gcagtgagca ccatggagct ggcggccttg tgccgctggg ggctcctcct cgccctcttg 60
ccccccggag ccgcgagcac ccaagtgtgc accggcacag acatgaagct gcggctccct 120
gccagtcccg agacccacct ggacatgctc cgccacctct accagggatg ccaggtggtg 180
cagggaaacc tggaactcac ctacctgccc accaatgcca gcctgtcctt cctgcaggat 240
atccaggagg tgcagggcta cgtgctcatc gctcacaacc aagtgaggca ggtcccactg 300
cagaggctgc ggattgtgcg aggcacccag ctctttgagg acaactatgc cctggccgtg 360
ctagacaatg gagacccgct gaacaatacc acccctgtca caggggcctc cccaggaggc 420
ctgcgggagc tgcagcttcg aagcctcaca gagatcttga aaggaggggt cttgatccag 480
cggaaccccc agctctgcta ccaggacacg attttgtgga aggacatctt ccacaagaac 540
aaccagctgg ctctcacact gatagacacc aaccgctctc gggcctgcca cccctgctct 600
ccgatgtgta agggctcccg ctgctgggga gagagttctg aggattgtca gagcctgacg 660
cgcactgtct gtgccggtgg ctgtgcccgc tgcaaggggc cactgcccac tgactgctgc 720
catgagcagt gtgctgccgg ctgcacgggc cccaagcact ctgactgcct ggcctgcctc 780
cacttcaacc acagtggcat ctgtgagctg cactgcccag ccctggtcac ctacaacaca 840
gacacgtttg agtccatgcc caatcccgag ggccggtata cattcggcgc cagctgtgtc 900
actgcctgtc cctacaacta cctttctacg gacgtgggat cctgcaccct cgtctgcccc 960
ctgcacaacc aagaggtgac agcagaggat ggaacacagc ggtgtgagaa gtgcagcaag 1020
ccctgtgccc gaggtaccca ctcactgcnc ccgaggccag ctgcagttcc tgtccctctg 1080
cgcatgcagc ctggcccagc ccaccctgtc ctatccttcc tcagaccctc ttgggaccta 1140
gtctctgcct tctactctct acccctggcc cccctcagcc ctacaagtgt ccctatatcc 1200
cctgtcagtg tggggagggg cccggaccct gatgctcatg tggctgttna cctgtcccgg 1260
tatgaaggct gagacggccc cttccccacc cacccccacc tcctcagtgt gctatg     1316

<210> 319
<211> 79
<212> PRT
<213> Homo sapiens

<220> 
<223> Intron 8

<400> 319
Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val Pro Val Pro Leu
 1               5                  10                  15      
Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser Phe Leu Arg Pro
            20                  25                  30          
Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro Leu Ala Pro Leu
        35                  40                  45              
Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val Gly Arg Gly Pro
    50                  55                  60                  
Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg Tyr Glu Gly
65                  70                  75                  
   
<210> 320
<211> 79
<212> PRT
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> VARIANT        
<222> 2
<223> Xaa= Thr or Ser

<400> 320
Gly Xaa His Ser Leu Pro Pro Arg Pro Ala Ala Val Pro Val Pro Leu
 1               5                  10                  15      
Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser Phe Leu Arg Pro
            20                  25                  30          
Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro Leu Ala Pro Leu
        35                  40                  45              
Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val Gly Arg Gly Pro
    50                  55                  60                  
Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg Tyr Glu Gly
65                  70                  75                  

<210> 321
<211> 79
<212> PRT
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> VARIANT        
<222> 5
<223> Xaa= Leu or Pro

<400> 321
Gly Thr His Ser Xaa Pro Pro Arg Pro Ala Ala Val Pro Val Pro Leu
 1               5                  10                  15      
Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser Phe Leu Arg Pro
            20                  25                  30          
Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro Leu Ala Pro Leu
        35                  40                  45              
Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val Gly Arg Gly Pro
    50                  55                  60                  
Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg Tyr Glu Gly
65                  70                  75                  

<210> 322
<211> 79
<212> PRT
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> VARIANT        
<222> 6
<223> Xaa= Pro or Leu

<400> 322
Gly Thr His Ser Leu Xaa Pro Arg Pro Ala Ala Val Pro Val Pro Leu
 1               5                  10                  15      
Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser Phe Leu Arg Pro
            20                  25                  30          
Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro Leu Ala Pro Leu
        35                  40                  45              
Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val Gly Arg Gly Pro
    50                  55                  60                  
Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg Tyr Glu Gly
65                  70                  75                  

<210> 323
<211> 79
<212> PRT
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> VARIANT        
<222> 16
<223> Xaa= Leu or Gln

<400> 323
Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val Pro Val Pro Xaa
 1               5                  10                  15      
Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser Phe Leu Arg Pro
            20                  25                  30          
Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro Leu Ala Pro Leu
        35                  40                  45              
Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val Gly Arg Gly Pro
    50                  55                  60                  
Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg Tyr Glu Gly
65                  70                  75                  

<210> 324
<211> 79
<212> PRT
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> VARIANT        
<222> 17
<223> Xaa= Arg or Cys

<400> 324
Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val Pro Val Pro Leu
 1               5                  10                  15      
Xaa Met Gln Pro Gly Pro Ala His Pro Val Leu Ser Phe Leu Arg Pro
            20                  25                  30          
Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro Leu Ala Pro Leu
        35                  40                  45              
Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val Gly Arg Gly Pro
    50                  55                  60                  
Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg Tyr Glu Gly
65                  70                  75                  

<210> 325
<211> 79
<212> PRT
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> VARIANT        
<222> 18
<223> Xaa= Met or Leu

<400> 325
Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val Pro Val Pro Leu
 1               5                  10                  15      
Arg Xaa Gln Pro Gly Pro Ala His Pro Val Leu Ser Phe Leu Arg Pro
            20                  25                  30          
Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro Leu Ala Pro Leu
        35                  40                  45              
Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val Gly Arg Gly Pro
    50                  55                  60                  
Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg Tyr Glu Gly
65                  70                  75                  

<210> 326
<211> 79
<212> PRT
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> VARIANT        
<222> 18
<223> Xaa= Met or Ile

<400> 326
Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val Pro Val Pro Leu
 1               5                  10                  15      
Arg Xaa Gln Pro Gly Pro Ala His Pro Val Leu Ser Phe Leu Arg Pro
            20                  25                  30          
Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro Leu Ala Pro Leu
        35                  40                  45              
Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val Gly Arg Gly Pro
    50                  55                  60                  
Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg Tyr Glu Gly
65                  70                  75                  

<210> 327
<211> 79
<212> PRT
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> VARIANT        
<222> 21
<223> Xaa= Gly, Asp, Ala, or Val

<400> 327
Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val Pro Val Pro Leu
 1               5                  10                  15      
Arg Met Gln Pro Xaa Pro Ala His Pro Val Leu Ser Phe Leu Arg Pro
            20                  25                  30          
Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro Leu Ala Pro Leu
        35                  40                  45              
Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val Gly Arg Gly Pro
    50                  55                  60                  
Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg Tyr Glu Gly
65                  70                  75                  


<210> 328
<211> 79
<212> PRT
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> VARIANT        
<222> 31
<223> Xaa= Arg or Ile

<400> 328
Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val Pro Val Pro Leu
 1               5                  10                  15      
Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser Phe Leu Xaa Pro
            20                  25                  30          
Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro Leu Ala Pro Leu
        35                  40                  45              
Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val Gly Arg Gly Pro
    50                  55                  60                  
Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg Tyr Glu Gly
65                  70                  75                  

<210> 329
<211> 79
<212> PRT
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> VARIANT        
<222> 36
<223> Xaa= Leu or Ile

<400> 329
Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val Pro Val Pro Leu
 1               5                  10                  15      
Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser Phe Leu Arg Pro
            20                  25                  30          
Ser Trp Asp Xaa Val Ser Ala Phe Tyr Ser Leu Pro Leu Ala Pro Leu
        35                  40                  45              
Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val Gly Arg Gly Pro
    50                  55                  60                  
Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg Tyr Glu Gly
65                  70                  75                  

<210> 330
<211> 79
<212> PRT
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> VARIANT        
<222> 54
<223> Xaa= Pro or Arg

<400> 330
Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val Pro Val Pro Leu
 1               5                  10                  15      
Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser Phe Leu Arg Pro
            20                  25                  30          
Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro Leu Ala Pro Leu
        35                  40                  45              
Ser Pro Thr Ser Val Xaa Ile Ser Pro Val Ser Val Gly Arg Gly Pro
    50                  55                  60                  
Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg Tyr Glu Gly
65                  70                  75                  

<210> 331
<211> 79
<212> PRT
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> VARIANT        
<222> 64
<223> Xaa= Pro or Leu

<400> 331
Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val Pro Val Pro Leu
 1               5                  10                  15      
Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser Phe Leu Arg Pro
            20                  25                  30          
Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro Leu Ala Pro Leu
        35                  40                  45              
Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val Gly Arg Gly Xaa
    50                  55                  60                  
Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg Tyr Glu Gly
65                  70                  75                  

<210> 332
<211> 79
<212> PRT
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> VARIANT        
<222> 73
<223> Xaa= Asp, His, or Asn

<400> 332
Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val Pro Val Pro Leu
 1               5                  10                  15      
Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser Phe Leu Arg Pro
            20                  25                  30          
Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro Leu Ala Pro Leu
        35                  40                  45              
Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val Gly Arg Gly Pro
    50                  55                  60                  
Asp Pro Asp Ala His Val Ala Val Xaa Leu Ser Arg Tyr Glu Gly
65                  70                  75                  

<210> 333
<211> 79
<212> PRT
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> VARIANT        
<222> 6
<223> Xaa= Pro or Leu

<220> 
<221> VARIANT        
<222> 73
<223> Xaa= Asp, His or Asn

<400> 333
Gly Thr His Ser Leu Xaa Pro Arg Pro Ala Ala Val Pro Val Pro Leu
 1               5                  10                  15      
Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser Phe Leu Arg Pro
            20                  25                  30          
Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro Leu Ala Pro Leu
        35                  40                  45              
Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val Gly Arg Gly Pro
    50                  55                  60                  
Asp Pro Asp Ala His Val Ala Val Xaa Leu Ser Arg Tyr Glu Gly
65                  70                  75                  

<210> 334
<211> 240
<212> DNA
<213> Homo sapiens

<220> 
<223> Intron 8

<400> 334
ggtacccact cactgccccc gaggccagct gcagttcctg tccctctgcg catgcagcct 60
ggcccagccc accctgtcct atccttcctc agaccctctt gggacctagt ctctgccttc 120
tactctctac ccctggcccc cctcagccct acaagtgtcc ctatatcccc tgtcagtgtg 180
gggaggggcc cggaccctga tgctcatgtg gctgttgacc tgtcccggta tgaaggctga 240

<210> 335
<211> 240
<212> DNA
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> allele   
<222> 4
<223> n= A or T

<400> 335
ggtncccact cactgccccc gaggccagct gcagttcctg tccctctgcg catgcagcct 60
ggcccagccc accctgtcct atccttcctc agaccctctt gggacctagt ctctgccttc 120
tactctctac ccctggcccc cctcagccct acaagtgtcc ctatatcccc tgtcagtgtg 180
gggaggggcc cggaccctga tgctcatgtg gctgttgacc tgtcccggta tgaaggctga 240

<210> 336
<211> 240
<212> DNA
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> allele
<222> 14
<223> n= T or C 

<400> 336
ggtacccact cacngccccc gaggccagct gcagttcctg tccctctgcg catgcagcct 60
ggcccagccc accctgtcct atccttcctc agaccctctt gggacctagt ctctgccttc 120
tactctctac ccctggcccc cctcagccct acaagtgtcc ctatatcccc tgtcagtgtg 180
gggaggggcc cggaccctga tgctcatgtg gctgttgacc tgtcccggta tgaaggctga 240

<210> 337
<211> 240
<212> DNA
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> allele
<222> 17
<223> n= C or T

<400> 337
ggtacccact cactgcnccc gaggccagct gcagttcctg tccctctgcg catgcagcct 60
ggcccagccc accctgtcct atccttcctc agaccctctt gggacctagt ctctgccttc 120
tactctctac ccctggcccc cctcagccct acaagtgtcc ctatatcccc tgtcagtgtg 180
gggaggggcc cggaccctga tgctcatgtg gctgttgacc tgtcccggta tgaaggctga 240


<210> 338
<211> 240
<212> DNA
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> allele
<222> 47
<223> n= T or A 

<400> 338
ggtacccact cactgccccc gaggccagct gcagttcctg tccctcngcg catgcagcct 60
ggcccagccc accctgtcct atccttcctc agaccctctt gggacctagt ctctgccttc 120
tactctctac ccctggcccc cctcagccct acaagtgtcc ctatatcccc tgtcagtgtg 180
gggaggggcc cggaccctga tgctcatgtg gctgttgacc tgtcccggta tgaaggctga 240


<210> 339
<211> 240
<212> DNA
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> allele
<222> 49
<223> n= C or T

<400> 339
ggtacccact cactgccccc gaggccagct gcagttcctg tccctctgng catgcagcct 60
ggcccagccc accctgtcct atccttcctc agaccctctt gggacctagt ctctgccttc 120
tactctctac ccctggcccc cctcagccct acaagtgtcc ctatatcccc tgtcagtgtg 180
gggaggggcc cggaccctga tgctcatgtg gctgttnacc tgtcccggta tgaaggctga 240

<210> 340
<211> 240
<212> DNA
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> allele
<222> 52
<223> n= A or C 

<400> 340
ggtacccact cactgccccc gaggccagct gcagttcctg tccctctgcg cntgcagcct 60
ggcccagccc accctgtcct atccttcctc agaccctctt gggacctagt ctctgccttc 120
tactctctac ccctggcccc cctcagccct acaagtgtcc ctatatcccc tgtcagtgtg 180
gggaggggcc cggaccctga tgctcatgtg gctgttgacc tgtcccggta tgaaggctga 240

<210> 341
<211> 240
<212> DNA
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> allele
<222> 54
<223> n= G or A 

<400> 341
ggtacccact cactgccccc gaggccagct gcagttcctg tccctctgcg catncagcct 60
ggcccagccc accctgtcct atccttcctc agaccctctt gggacctagt ctctgccttc 120
tactctctac ccctggcccc cctcagccct acaagtgtcc ctatatcccc tgtcagtgtg 180
gggaggggcc cggaccctga tgctcatgtg gctgttgacc tgtcccggta tgaaggctga 240

<210> 342
<211> 240
<212> DNA
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> allele
<222> 62
<223> n= G, C, T, or A

<400> 342
ggtacccact cactgccccc gaggccagct gcagttcctg tccctctgcg catgcagcct 60
gncccagccc accctgtcct atccttcctc agaccctctt gggacctagt ctctgccttc 120
tactctctac ccctggcccc cctcagccct acaagtgtcc ctatatcccc tgtcagtgtg 180
gggaggggcc cggaccctga tgctcatgtg gctgttgacc tgtcccggta tgaaggctga 240


<210> 343
<211> 240
<212> DNA
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> allele
<222> 92
<223> n= G or T

<400> 343
ggtacccact cactgccccc gaggccagct gcagttcctg tccctctgcg catgcagcct 60
ggcccagccc accctgtcct atccttcctc anaccctctt gggacctagt ctctgccttc 120
tactctctac ccctggcccc cctcagccct acaagtgtcc ctatatcccc tgtcagtgtg 180
gggaggggcc cggaccctga tgctcatgtg gctgttnacc tgtcccggta tgaaggctga 240
  

<210> 344
<211> 240
<212> DNA
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> allele
<222> 106
<223> n= C or A 

<400> 344
ggtacccact cactgccccc gaggccagct gcagttcctg tccctctgcg catgcagcct 60
ggcccagccc accctgtcct atccttcctc agaccctctt gggacntagt ctctgccttc 120
tactctctac ccctggcccc cctcagccct acaagtgtcc ctatatcccc tgtcagtgtg 180
gggaggggcc cggaccctga tgctcatgtg gctgttgacc tgtcccggta tgaaggctga 240


<210> 345
<211> 240
<212> DNA
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> allele
<222> 161
<223> n= C or G 

<400> 345
ggtacccact cactgccccc gaggccagct gcagttcctg tccctctgcg catgcagcct 60
ggcccagccc accctgtcct atccttcctc agaccctctt gggacctagt ctctgccttc 120
tactctctac ccctggcccc cctcagccct acaagtgtcc ntatatcccc tgtcagtgtg 180
gggaggggcc cggaccctga tgctcatgtg gctgttgacc tgtcccggta tgaaggctga 240


<210> 346
<211> 240
<212> DNA
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> allele
<222> 191
<223> n= C or T 

<400> 346
ggtacccact cactgccccc gaggccagct gcagttcctg tccctctgcg catgcagcct 60
ggcccagccc accctgtcct atccttcctc agaccctctt gggacctagt ctctgccttc 120
tactctctac ccctggcccc cctcagccct acaagtgtcc ctatatcccc tgtcagtgtg 180
gggaggggcc nggaccctga tgctcatgtg gctgttgacc tgtcccggta tgaaggctga 240

<210> 347
<211> 240
<212> DNA
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> allele
<222> 217
<223> n= G, C, or A

<400> 347
ggtacccact cactgccccc gaggccagct gcagttcctg tccctctgcg catgcagcct 60
ggcccagccc accctgtcct atccttcctc agaccctctt gggacctagt ctctgccttc 120
tactctctac ccctggcccc cctcagccct acaagtgtcc ctatatcccc tgtcagtgtg 180
gggaggggcc cggaccctga tgctcatgtg gctgttnacc tgtcccggta tgaaggctga 240

	
<210> 348
<211> 240
<212> DNA
<213> Homo sapiens

<220> 
<223> Intron 8 variant

<220> 
<221> allele
<222> 17
<223> n= C or T

<220>
<221> allele
<222> 217
<223> n= G, C, or A

<400> 348
ggtacccact cactgcnccc gaggccagct gcagttcctg tccctctgcg catgcagcct 60
ggcccagccc accctgtcct atccttcctc agaccctctt gggacctagt ctctgccttc 120
tactctctac ccctggcccc cctcagccct acaagtgtcc ctatatcccc tgtcagtgtg 180
gggaggggcc cggaccctga tgctcatgtg gctgttnacc tgtcccggta tgaaggctga 240

<210> 349
<211> 1471
<212> DNA
<213> Homo sapiens

<220> 
<223> SR023A02

<400> 349
cccaggcatc tcctccagag ggatccgcca gcccgtccag cagcaccatg tgggtgacca 60
aactcctgcc agccctgctg ctgcagcatg tcctcctgca tctcctcctg ctccccatcg 120
ccatccccta tgcagaggga caaaggaaaa gaagaaatac aattcatgaa ttcaaaaaat 180
cagcaaagac taccctaatc aaaatagatc cagcactgaa gataaaaacc aaaaaagtga 240
atactgcaga ccaatgtgct aatagatgta ctaggaataa aggacttcca ctcacttgca 300
aggcttttgt ttttgataaa gcaagaaaac aatgcctctg gttccccttc aatagcatgt 360
caagtggagt gaaaaaagaa tttggccatg aatttgacct ctatgaaaac aaagactaca 420
ttagaaactg catcattggt aaaggacgca gctacaaggg aacagtatct atcactaaga 480
gtggcatcaa atgtcagccc tggagttcca tgataccaca cgaacacagc tatcggggta 540
aagacctaca ggaaaactac tgtcgaaatc ctcgagggga agaaggggga ccctggtgtt 600
tcacaagcaa tccagaggta cgctacgaag tctgtgacat tcctcagtgt tcagaagttg 660
aatgcatgac ctgcaatggg gagagttatc gaggtctcat ggatcataca gaatcaggca 720
agatttgtca gcgctgggat catcagacac cacaccggca caaattcttg cctgaaagat 780
atcccgacaa gggctttgat gataattatt gccgcaatcc cgatggccag ccgaggccat 840
ggtgctatac tcttgaccct cacacccgct gggagtactg tgcaattaaa acatgcgctg 900
acaatactat gaatgacact gatgttcctt tggaaacaac tgaatgcatc caaggtcaag 960
gagaaggcta caggggcact gtcaatacca tttggaatgg aatttcatgt cagcgttggg 1020
attctcagta tcctcacgag catgacatga ctcctgaaaa tttcaagtgc aaggacctac 1080
gagaaaatta ctgccgaaat ccagatgggt ctgaatcacc ctggtgtttt accactgatc 1140
caaacatccg agttggctac tgctcccaaa ttccaaactg tgatatgtca catggacaag 1200
attgttatcg tgggaatggc aaaaattata tgggcaactt atcccaaaca agatctggac 1260
taacatgttc aatgtgggac aagaacatgg aagacttaca tcgtcatatc ttctgggaac 1320
cagatgcaag taagctgaat gagaattact gccgaaatcc agatgatgat gctcatggac 1380
cctggtgcta cacgggaaat ccactcattc cttgggatta ttgccctatt tctcgttgta 1440
agtacagtta gggattggtg tcttgtgaaa t                                1471

<210> 350
<211> 467
<212> PRT
<213> Homo sapiens

<220> 
<223> SR023A02

<400> 350
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu
 1               5                  10                  15      
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln
            20                  25                  30          
Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr
        35                  40                  45              
Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val
    50                  55                  60                  
Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu
65                  70                  75                  80  
Pro Leu Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys
                85                  90                  95      
Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe
            100                 105                 110         
Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys
        115                 120                 125             
Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys
    130                 135                 140                 
Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His
145                 150                 155                 160 
Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr Cys Arg Asn Pro Arg
                165                 170                 175     
Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser Asn Pro Glu Val Arg
            180                 185                 190         
Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu Val Glu Cys Met Thr
        195                 200                 205             
Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp His Thr Glu Ser Gly
    210                 215                 220                 
Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro His Arg His Lys Phe
225                 230                 235                 240 
Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp Asp Asn Tyr Cys Arg
                245                 250                 255     
Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr Thr Leu Asp Pro His
            260                 265                 270         
Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys Ala Asp Asn Thr Met
        275                 280                 285             
Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu Cys Ile Gln Gly Gln
    290                 295                 300                 
Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile Trp Asn Gly Ile Ser
305                 310                 315                 320 
Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu His Asp Met Thr Pro
                325                 330                 335     
Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn Tyr Cys Arg Asn Pro
            340                 345                 350         
Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr Asp Pro Asn Ile Arg
        355                 360                 365             
Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp Met Ser His Gly Gln
    370                 375                 380                 
Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met Gly Asn Leu Ser Gln
385                 390                 395                 400 
Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp Lys Asn Met Glu Asp
                405                 410                 415     
Leu His Arg His Ile Phe Trp Glu Pro Asp Ala Ser Lys Leu Asn Glu
            420                 425                 430         
Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His Gly Pro Trp Cys Tyr
        435                 440                 445             
Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys Pro Ile Ser Arg Cys
    450                 455                 460                 
Lys Tyr Ser
465         


<210> 351
<211> 1495
<212> DNA
<213> Homo sapiens

<220> 
<223> SR023A08

<400> 351
attctttcac ccaggcatct cctccagagg gatccgccag cccgtccagc agcaccatgt 60
gggtgaccaa actcctgcca gccctgctgc tgcagcatgt cctcctgcat ctcctcctgc 120
tccccatcgc catcccctat gcagagggac aaaggaaaag aagaaataca attcatgaat 180
tcaaaaaatc agcaaagact accctaatca aaatagatcc agcactgaag ataaaaacca 240
aaaaagtgaa tactgcagac caatgtgcta atagatgtac taggaataaa ggacttccat 300
tcacttgcaa ggcttttgtt tttgataaag caagaaaaca atgcctctgg ttccccttca 360
atagcatgtc aagtggagtg aaaaaagaat ttggccatga atttgacctc tatgaaaaca 420
aagactacat tagaaactgc atcattggta aaggacgcag ctacaaggga acagtatcta 480
tcactaagag tggcatcaaa tgtcagccct ggagttccat gataccacac gaacacagct 540
ttttgccttc gagctatcgg ggtaaagacc tacaggaaaa ctactgtcga aatcctcgag 600
gggaagaagg gggaccctgg tgtttcacaa gcaatccaga ggtacgctac gaagtctgtg 660
acattcctca gtgttcagaa gttgaatgca tgacctgcaa tggggagagt tatcgaggtc 720
tcatggatca tacagaatca ggcaagattt gtcagcgctg ggatcatcag acaccacacc 780
ggcacaaatt cttgcctgaa agatatcccg acaagggctt tgatgataat tattgccgca 840
atcccgatgg ccagccgagg ccatggtgct atactcttga ccctcacacc cgctgggagt 900
actgtgcaat taaaacatgc gctgacaata ctatgaatga cactgatgtt cctttggaaa 960
caactaaatg catccaaggt caaggagaag gctacagggg cactgtcaat accatttgga 1020
atggaattcc atgtcagcgt tgggattctc agtatcctca cgagcatgac atgactcctg 1080
aaaatttcaa gtgcaaggac ctacgagaaa attactgccg aaatccagat gggtctgaat 1140
caccctggtg ttttaccact gatccaaaca tccgagttgg ctactgctcc caaattccaa 1200
actgtgatat gtcacatgga caagattgtt atcgtgggaa tggcaaaaat tatatgggca 1260
acttatccca aacaagatct ggactaacat gttcaatgtg ggacaagaac atggaagact 1320
tacatcgtca tatcttctgg gaaccagatg caagtaagct gaatgagaat tactgccgaa 1380
atccagatga tgatgctcat ggaccctggt gctacacggg aaatccactc attccttggg 1440
attattgccc tatttctcgt tgtaagtaca gttagggatt ggtgtcttgt gaaat      1495

<210> 352
<211> 472
<212> PRT
<213> Homo sapiens

<220> 
<223> SR023A08

<400> 352
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu
 1               5                  10                  15      
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln
            20                  25                  30          
Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr
        35                  40                  45              
Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val
    50                  55                  60                  
Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu
65                  70                  75                  80  
Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys
                85                  90                  95      
Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe
            100                 105                 110         
Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys
        115                 120                 125             
Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys
    130                 135                 140                 
Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His
145                 150                 155                 160 
Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr
                165                 170                 175     
Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser
            180                 185                 190         
Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu
        195                 200                 205             
Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp
    210                 215                 220                 
His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro
225                 230                 235                 240 
His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp
                245                 250                 255     
Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr
            260                 265                 270         
Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys
        275                 280                 285             
Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Lys
    290                 295                 300                 
Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile
305                 310                 315                 320 
Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu
                325                 330                 335     
His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn
            340                 345                 350         
Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr
        355                 360                 365             
Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp
    370                 375                 380                 
Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met
385                 390                 395                 400 
Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp
                405                 410                 415     
Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala
            420                 425                 430         
Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His
        435                 440                 445             
Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys
    450                 455                 460                 
Pro Ile Ser Arg Cys Lys Tyr Ser
465                 470         


<210> 353
<211> 1613
<212> DNA
<213> Homo sapiens

<220> 
<223> SR023E09

<400> 353
agcaccatgt gggtgaccaa actcctgcca gccctgctgc tgcagcatgt cctcctgcat 60
ctcctcctgc tccccatcgc catcccctat gcagagggac aaaggaaaag aagaaataca 120
attcatgaat tcaaaaaatc agcaaagact accctaatca aaatagatcc agcactgaag 180
ataaaaacca aaaaagtgaa tactgcagac caatgtgcta atagatgtac taggaataaa 240
ggacttccat tcacttgcaa ggcttttgtt tttgataaag caagaaaaca atgcctctgg 300
ttccccttca atagcatgtc aagtggagtg aaaaaagaat ttggccatga atttgacctc 360
tatgaaaaca aagactacat tagaaactgc atcattggta aaggacgcag ctacaaggga 420
acagtatcta tcactaagag tggcatcaaa tgtcagccct ggagttccat gataccacac 480
gaacacagct ttttgccttc gagctatcgg ggtaaagacc tacaggaaaa ctactgtcga 540
aatcctcgag gggaagaagg gggaccctgg tgtttcacaa gcaatccaga ggtacgctac 600
gaagtctgtg acattcctca gtgttcagaa gttgaatgca tgacctgcaa tggggagagt 660
tatcgaggtc tcatggatca tacagaatca ggcaagattt gtcagcgctg ggatcatcag 720
acaccacacc ggcacaaatt cttgcctgaa agatatcccg acaagggctt tgatgataat 780
tattgccgca atcccgatgg ccagccgagg ccatggtgct atactcttga ccctcacacc 840
cgctgggagt actgtgcaat taaaacatgc gctgacaata ctatgaatga cactgatgtt 900
cctttggaaa caactgaatg catccaaggt caaggagaag gctacagggg cactgtcaat 960
accatttgga atggaattcc atgtcagcgt tgggattctc agtatcctca cgagcatgac 1020
atgactcctg aaaatttcaa gtgcaaggac ctacgagaaa attactgccg aaatccagat 1080
gggtctgaat caccctggtg ttttaccact gatccaaaca tccgagttgg ctactgctcc 1140
caaattccaa actgtgatat gtcacatgga caagattgtt atcgtgggaa tggcaaaaat 1200
tatatgggca acttatccca aacaagatct ggactaacat gttcaatgtg ggacaagaac 1260
atggaagact tacatcgtca tatcttctgg gaaccagatg caagtaagct gaatgagaat 1320
tactgccgaa atccagatga tgatgctcat ggaccctggt gctacacggg aaatccactc 1380
attccttggg attattgccc tatttctcgt tgtgaaggtg ataccacacc tacaatagtc 1440
aatttagacc atcccgtaat atcttgtgcc aaaacgaaac aattgcgagt tgtaaatggg 1500
attccaacac gaacaaacat aggatggatg gttagtttga gatacaggta attattaata 1560
gatgcaagtc atgcatatcc agaatatgta caagagagtc ctattcccag aaa        1613

<210> 354
<211> 514
<212> PRT
<213> Homo sapiens

<220> 
<223> SR023E09

<400> 354
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu
 1               5                  10                  15      
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln
            20                  25                  30          
Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr
        35                  40                  45              
Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val
    50                  55                  60                  
Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu
65                  70                  75                  80  
Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys
                85                  90                  95      
Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe
            100                 105                 110         
Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys
        115                 120                 125             
Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys
    130                 135                 140                 
Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His
145                 150                 155                 160 
Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr
                165                 170                 175     
Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser
            180                 185                 190         
Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu
        195                 200                 205             
Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp
    210                 215                 220                 
His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro
225                 230                 235                 240 
His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp
                245                 250                 255     
Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr
            260                 265                 270         
Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys
        275                 280                 285             
Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu
    290                 295                 300                 
Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile
305                 310                 315                 320 
Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu
                325                 330                 335     
His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn
            340                 345                 350         
Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr
        355                 360                 365             
Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp
    370                 375                 380                 
Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met
385                 390                 395                 400 
Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp
                405                 410                 415     
Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala
            420                 425                 430         
Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His
        435                 440                 445             
Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys
    450                 455                 460                 
Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu
465                 470                 475                 480 
Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val
                485                 490                 495     
Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg
            500                 505                 510         
Tyr Arg
        


<210> 355
<211> 3952
<212> DNA
<213> Homo Sapiens

<300> 
<308> GenBank No. NM013993
<309> 2004-10-28  

<400> 355
ggcttaggaa gtattaactg atctctgccc tagttctcat gtgttaaata tggatagtaa 60
tagtatctac cttatgaagt gactgtgaag ataaaattat ggattctgtt taagggttta 120
ggccagtgtc tggcacaggg gaagcattct aaaaatatag ctgatgctgt taaacaatga 180
ctgttgttgt tgttttactg ttattatccc caaagcggcc cattctgtct gttgctgtca 240
gctatgactc agtcccctga ttaacttacg caccacccat tttatcccct gcagagatgc 300
tgcccccacc cccttaggcc cgagggatca ggagctatgg gaccagaggc cctgtcatct 360
ttactgctgc tgctcttggt ggcaagtgga gatgctgaca tgaagggaca ttttgatcct 420
gccaagtgcc gctatgccct gggcatgcag gaccggacca tcccagacag tgacatctct 480
gcttccagct cctggtcaga ttccactgcc gcccgccaca gcaggttgga gagcagtgac 540
ggggatgggg cctggtgccc cgcagggtcg gtgtttccca aggaggagga gtacttgcag 600
gtggatctac aacgactgca cctggtggct ctggtgggca cccagggacg gcatgccggg 660
ggcctgggca aggagttctc ccggagctac cggctgcgtt actcccggga tggtcgccgc 720
tggatgggct ggaaggaccg ctggggtcag gaggtgatct caggcaatga ggaccctgag 780
ggagtggtgc tgaaggacct tgggcccccc atggttgccc gactggttcg cttctacccc 840
cgggctgacc gggtcatgag cgtctgtctg cgggtagagc tctatggctg cctctggagg 900
gatggactcc tgtcttacac cgcccctgtg gggcagacaa tgtatttatc tgaggccgtg 960
tacctcaacg actccaccta tgacggacat accgtgggcg gactgcagta tgggggtctg 1020
ggccagctgg cagatggtgt ggtggggctg gatgacttta ggaagagtca ggagctgcgg 1080
gtctggccag gctatgacta tgtgggatgg agcaaccaca gcttctccag tggctatgtg 1140
gagatggagt ttgagtttga ccggctgagg gccttccagg ctatgcaggt ccactgtaac 1200
aacatgcaca cgctgggagc ccgtctgcct ggcggggtgg aatgtcgctt ccggcgtggc 1260
cctgccatgg cctgggaggg ggagcccatg cgccacaacc tagggggcaa cctgggggac 1320
cccagagccc gggctgtctc agtgcccctt ggcggccgtg tggctcgctt tctgcagtgc 1380
cgcttcctct ttgcggggcc ctggttactc ttcagcgaaa tctccttcat ctctgatgtg 1440
gtgaacaatt cctctccggc actgggaggc accttcccgc cagccccctg gtggccgcct 1500
ggcccacctc ccaccaactt cagcagcttg gagctggagc ccagaggcca gcagcccgtg 1560
gccaaggccg aggggagccc gaccgccatc ctcatcggct gcctggtggc catcatcctg 1620
ctcctgctgc tcatcattgc cctcatgctc tggcggctgc actggcgcag gctcctcagc 1680
aaggctgaac ggagggtgtt ggaagaggag ctgacggttc acctctctgt ccctggggac 1740
actatcctca tcaacaaccg cccaggtcct agagagccac ccccgtacca ggagccccgg 1800
cctcgtggga atccgcccca ctccgctccc tgtgtcccca atggctctgc gttgctgctc 1860
tccaatccag cctaccgcct ccttctggcc acttacgccc gtccccctcg aggcccgggc 1920
ccccccacac ccgcctgggc caaacccacc aacacccagg cctacagtgg ggactatatg 1980
gagcctgaga agccaggcgc cccgcttctg cccccacctc cccagaacag cgtcccccat 2040
tatgccgagg ctgacattgt taccctgcag ggcgtcaccg ggggcaacac ctatgctgtg 2100
cctgcactgc ccccaggggc agtcggggat gggcccccca gagtggattt ccctcgatct 2160
cgactccgct tcaaggagaa gcttggcgag ggccagtttg gggaggtgca cctgtgtgag 2220
gtcgacagcc ctcaagatct ggttagtctt gatttccccc ttaatgtgcg taagggacac 2280
cctttgctgg tagctgtcaa gatcttacgg ccagatgcca ccaagaatgc caggaatgat 2340
ttcctgaaag aggtgaagat catgtcgagg ctcaaggacc caaacatcat tcggctgctg 2400
ggcgtgtgtg tgcaggacga ccccctctgc atgattactg actacatgga gaacggcgac 2460
ctcaaccagt tcctcagtgc ccaccagctg gaggacaagg cagccgaggg ggcccctggg 2520
gacgggcagg ctgcgcaggg gcccaccatc agctacccaa tgctgctgca tgtggcagcc 2580
cagatcgcct ccggcatgcg ctatctggcc acactcaact ttgtacatcg ggacctggcc 2640
acgcggaact gcctagttgg ggaaaatttc accatcaaaa tcgcagactt tggcatgagc 2700
cggaacctct atgctgggga ctattaccgt gtgcagggcc gggcagtgct gcccatccgc 2760
tggatggcct gggagtgcat cctcatgggg aagttcacga ctgcgagtga cgtgtgggcc 2820
tttggtgtga ccctgtggga ggtgctgatg ctctgtaggg cccagccctt tgggtcagct 2880
caccgacgag caggtcatcg agaacgcggg ggagttcttc cgggaccagg gccggcagtg 2940
tacctgtccc ggccgcctgc ctgcccgcag ggcctatatg agctgatgct tcggtgctgg 3000
agccgggagt ctgagcagcg accacccttt tcccagctgc atcggttcct ggcagaggat 3060
gcactcaaca cggtgtgaat cacacatcca gctgcccctc cctcagggag cgatccaggg 3120
gaagccagtg acactaaaac aagaggacac aatggcacct ctgcccttcc cctcccgaca 3180
gcccatcacc tctaatagag gcagtgagac tgcaggtggg ctgggcccac ccagggagct 3240
gatgcccctt ctccccttcc tggacacact ctcatgtccc cttcctgttc ttccttccta 3300
gaagcccccc tgtcgcccac ccagctggtc ctgtggatgg gatcctctcc accctcctct 3360
agccatccct tggggaaggg tggggagaaa tataggatag acactggaca tggcccattg 3420
gagcacctgg gccccactgg acaacactga ttcctggaga ggtggctgcg cccccagctt 3480
ctctctccct gtcacacact ggaccccact ggctgagaat ctgggggtga ggaggacaag 3540
aaggagagga aaatgtttcc ttgtgcctgc tcctgtactt gtcctcagct tgggcttctt 3600
cctcctccat cacctgaaac actggacctg ggggtagccc cgccccagcc ctcagtcacc 3660
cccacttccc acttgcagtc ttgtagctag aacttctcta agcctatacg tttctgtgga 3720
gtaaatattg ggattggggg gaaagaggga gcaacggccc atagccttgg ggttggacat 3780
ctctagtgta gctgccacat tgatttttct ataatcactt ggggtttgta catttttggg 3840
gggagagaca cagattttta cactaatata tggacctagc ttgaggcaat tttaatcccc 3900
tgcactaggc aggtaataat aaaggttgag ttttccacaa aaaaaaaaaa aa         3952

<210> 356
<211> 3096
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM006182
<309> 2004-10-26  

<400> 356
catcttgcat cagcctgtgg atgtatgcct accaccgggc tccttcacca gcaaagtgga 60
aaaagaagcg tttcacaaca aattcttctt tttgggttgg ggaaacgcag tggattatag 120
ctctgttttc ttctttccaa aactgtgcac ccctggatga aacctccatc aagggagacc 180
tacaagttgc ctggggttca gtgctctaga aagttccaag gtttgtggct tgaattattc 240
taaagaagct gaaataattg aagagaagca gaggccagct gtttttgagg atcctgctcc 300
acagagaatg ctctgcaccc gttgatactc cagttccaac accatcttct gagatgatcc 360
tgattcccag aatgctcttg gtgctgttcc tgctgctgcc tatcttgagt tctgcaaaag 420
ctcaggttaa tccagctata tgccgctatc ctctgggcat gtcaggaggc cagattccag 480
atgaggacat cacagcttcc agtcagtggt cagagtccac agctgccaaa tatggaaggc 540
tggactcaga agaaggggat ggagcctggt gccctgagat tccagtggaa cctgatgacc 600
tgaaggagtt tctgcagatt gacttgcaca ccctccattt tatcactctg gtggggaccc 660
aggggcgcca tgcaggaggt catggcatcg agtttgcccc catgtacaag atcaattaca 720
gtcgggatgg cactcgctgg atctcttggc ggaaccgtca tgggaaacag gtgctggatg 780
gaaatagtaa cccctatgac attttcctaa aggacttgga gccgcccatt gtagccagat 840
ttgtccggtt cattccagtc accgaccact ccatgaatgt gtgtatgaga gtggagcttt 900
acggctgtgt ctggctagat ggcttggtgt cttacaatgc tccagctggg cagcagtttg 960
tactccctgg aggttccatc atttatctga atgattctgt ctatgatgga gctgttggat 1020
acagcatgac agaagggcta ggccaattga ccgatggtgt gtctggcctg gacgatttca 1080
cccagaccca tgaataccac gtgtggcccg gctatgacta tgtgggctgg cggaacgaga 1140
gtgccaccaa tggctacatt gagatcatgt ttgaatttga ccgcatcagg aatttcacta 1200
ccatgaaggt ccactgcaac aacatgtttg ctaaaggtgt gaagatcttt aaggaggtac 1260
agtgctactt ccgctctgaa gccagtgagt gggaacctaa tgccatttcc ttcccccttg 1320
tcctggatga cgtcaacccc agtgctcggt ttgtcacggt gcctctccac caccgaatgg 1380
ccagtgccat caagtgtcaa taccattttg cagatacctg gatgatgttc agtgagatca 1440
ccttccaatc agatgctgca atgtacaaca actctgaagc cctgcccacc tctcctatgg 1500
cacccacaac ctatgatcca atgcttaaag ttgatgacag caacactcgg atcctgattg 1560
gctgcttggt ggccatcatc tttatcctcc tggccatcat tgtcatcatc ctctggaggc 1620
agttctggca gaaaatgctg gagaaggctt ctcggaggat gctggatgat gaaatgacag 1680
tcagcctttc cctgccaagt gattctagca tgttcaacaa taaccgctcc tcatcaccta 1740
gtgaacaagg gtccaactcg acttacgatc gcatctttcc ccttcgccct gactaccagg 1800
agccatccag gctgatacga aaactcccag aatttgctcc aggggaggag gagtcaggct 1860
gcagcggtgt tgtgaagcca gtccagccca gtggccctga gggggtgccc cactatgcag 1920
aggctgacat agtgaacctc caaggagtga caggaggcaa cacatactca gtgcctgccg 1980
tcaccatgga cctgctctca ggaaaagatg tggctgtgga ggagttcccc aggaaactcc 2040
taactttcaa agagaagctg ggagaaggac agtttgggga ggttcatctc tgtgaagtgg 2100
agggaatgga aaaattcaaa gacaaagatt ttgccctaga tgtcagtgcc aaccagcctg 2160
tcctggtggc tgtgaaaatg ctccgagcag atgccaacaa gaatgccagg aatgattttc 2220
ttaaggagat aaagatcatg tctcggctca aggacccaaa catcatccat ctattatctg 2280
tgtgtatcac tgatgaccct ctctgtatga tcactgaata catggagaat ggagatctca 2340
atcagtttct ttcccgccac gagcccccta attcttcctc cagcgatgta cgcactgtca 2400
gttacaccaa tctgaagttt atggctaccc aaattgcctc tggcatgaag tacctttcct 2460
ctcttaattt tgttcaccga gatctggcca cacgaaactg tttagtgggt aagaactaca 2520
caatcaagat agctgacttt ggaatgagca ggaacctgta cagtggtgac tattaccgga 2580
tccagggccg ggcagtgctc cctatccgct ggatgtcttg ggagagtatc ttgctgggca 2640
agttcactac agcaagtgat gtgtgggcct ttggggttac tttgtgggag actttcacct 2700
tttgtcaaga acagccctat tcccagctgt cagatgaaca ggttattgag aatactggag 2760
agttcttccg agaccaaggg aggcagactt acctccctca accagccatt tgtcctgact 2820
ctgtgtataa gctgatgctc agctgctgga gaagagatac gaagaaccgt ccctcattcc 2880
aagaaatcca ccttctgctc cttcaacaag gcgacgagtg atgctgtcag tgcctggcca 2940
tgttcctacg gctcaggtcc tccctacaag acctaccact cacccatgcc tatgccactc 3000
catctggaca tttaatgaaa ctgagagaca gaggcttgtt tgctttgccc tcttttcctg 3060
gtcaccccca ctccctaccc ctgactcata tatact                           3096

<210> 357
<211> 3363
<212> DNA
<213> Homo Sapiens

<300> 
<308> GenBank No. NM005232
<309> 2004-11-29  

<400> 357
gcccccgccc ggcccgcccc gctctcctag tcccttgcaa cctggcgctg ccatccgggc 60
cactgtccca ggtcccggcc cggagctatg gagcggcgct ggcccctggg gctagggctg 120
gtgctgctgc tctgcgcccc gctgcccccg ggggcgcgcg ccaaggaagt tactctgatg 180
gacacaagca aggcacaggg agagctgggc tggctgctgg atcccccaaa agatgggtgg 240
agtgaacagc aacagatact gaatgggaca cccctgtaca tgtaccagga ctgcccaatg 300
caaggacgca gagacactga ccactggctt cgctccaatt ggatctaccg cggggaggag 360
gcttcccgcg tccacgtgga gctgcagttc accgtgcggg actgcaagag tttccctggg 420
ggagccgggc ctctgggctg caaggagacc ttcaaccttc tgtacatgga gagtgaccag 480
gatgtgggca ttcagctccg acggcccttg ttccagaagg taaccacggt ggctgcagac 540
cagagcttca ccattcgaga ccttgcgtct ggctccgtga agctgaatgt ggagcgctgc 600
tctctgggcc gcctgacccg ccgtggcctc tacctcgctt tccacaaccc gggtgcctgt 660
gtggccctgg tgtctgtccg ggtcttctac cagcgctgtc ctgagaccct gaatggcttg 720
gcccaattcc cagacactct gcctggcccc gctgggttgg tggaagtggc ggggacctgc 780
ttgccccacg cgcgggccag ccccaggccc tcaggtgcac cccgcatgca ctgcagccct 840
gatggcgagt ggctggtgcc tgtaggacgg tgccactgtg agcctggcta tgaggaaggt 900
ggcagtggcg aagcatgtgt tgcctgccct agcggctcct accggatgga catggacaca 960
ccccattgtc tcacgtgccc ccagcagagc actgctgagt ctgagggggc caccatctgt 1020
acctgtgaga gcggccatta cagagctccc ggggagggcc cccaggtggc atgcacaggt 1080
cccccctcgg ccccccgaaa cctgagcttc tctgcctcag ggactcagct ctccctgcgt 1140
tgggaacccc cagcagatac ggggggacgc caggatgtca gatacagtgt gaggtgttcc 1200
cagtgtcagg gcacagcaca ggacgggggg ccctgccagc cctgtggggt gggcgtgcac 1260
ttctcgccgg gggcccgggc gctcaccaca cctgcagtgc atgtcaatgg ccttgaacct 1320
tatgccaact acacctttaa tgtggaagcc caaaatggag tgtcagggct gggcagctct 1380
ggccatgcca gcacctcagt cagcatcagc atggggcatg cagagtcact gtcaggcctg 1440
tctctgagac tggtgaagaa agaaccgagg caactagagc tgacctgggc ggggtcccgg 1500
ccccgaagcc ctggggcgaa cctgacctat gagctgcacg tgctgaacca ggatgaagaa 1560
cggtaccaga tggttctaga acccagggtc ttgctgacag agctgcagcc tgacaccaca 1620
tacatcgtca gagtccgaat gctgacccca ctgggtcctg gccctttctc ccctgatcat 1680
gagtttcgga ccagcccacc agtgtccagg ggcctgactg gaggagagat tgtagccgtc 1740
atctttgggc tgctgcttgg tgcagccttg ctgcttggga ttctcgtttt ccggtccagg 1800
agagcccagc ggcagaggca gcagaggcag cgtgaccgcg ccaccgatgt ggatcgagag 1860
gacaagctgt ggctgaagcc ttatgtggac ctccaggcat acgaggaccc tgcacaggga 1920
gccttggact ttacccggga gcttgatcca gcgtggctga tggtggacac tgtcatagga 1980
gaaggagagt ttggggaagt gtatcgaggg accctgaggc tccccagcca ggactgcaag 2040
actgtggcca ttaagacctt aaaagacaca tccccaggtg gccagtggtg gaacttcctt 2100
cgagaggcaa ctatcatggg ccagtttagc cacccgcata ttctgcatct ggaaggcgtc 2160
gtcacaaagc gaaagccgat catgatcatc acagaattta tggagaatgg agccctggat 2220
gccttcctga gggagcggga ggaccagctg gtccctgggc agctagtggc catgctgcag 2280
ggcatagcat ctggcatgaa ctacctcagt aatcacaatt atgtccaccg ggacctggct 2340
gccagaaaca tcttggtgaa tcaaaacctg tgctgcaagg tgtctgactt tggcctgact 2400
cgcctcctgg atgactttga tggcacatac gaaacccagg gaggaaagat ccctatccgt 2460
tggacagccc ctgaagccat tgcccatcgg atcttcacca cagccagcga tgtgtggagc 2520
tttgggattg tgatgtggga ggtgctgagc tttggggaca agccttatgg ggagatgagc 2580
aatcaggagg ttatgaagag cattgaggat gggtaccggt tgccccctcc tgtggactgc 2640
cctgcccctc tgtatgagct catgaagaac tgctgggcat atgaccgtgc ccgccggcca 2700
cacttccaga agcttcaggc acatctggag caactgcttg ccaaccccca ctccctgcgg 2760
accattgcca actttgaccc cagggtgact cttcgcctgc ccagcctgag tggctcagat 2820
gggatcccgt atcgaaccgt ctctgagtgg ctcgagtcca tacgcatgaa acgctacatc 2880
ctgcacttcc actcggctgg gctggacacc atggagtgtg tgctggagct gaccgctgag 2940
gacctgacgc agatgggaat cacactgccc gggcaccaga agcgcattct ttgcagtatt 3000
cagggattca aggactgatc cctcctctca ccccatgccc aatcagggtg caaggagcaa 3060
ggacggggcc aaggtcgctc atggtcactc cctgcgcccc ttcccacaac ctgccagact 3120
aggctatcgg tgctgcttct gcccactttc aggagaaccc tgctctgcac cccagaaaac 3180
ctctttgttt taaaagggag gtgggggtag aagtaaaagg atgatcatgg gagggagctg 3240
aggggttaat atatatacat acatacacat atatatattt ttgtaaataa acaggaactg 3300
attttctgcc tccatcccac ccatgagggc tgcaggcact acaaaagagc tgactactga 3360
gaa                                                               3363

<210> 358
<211> 3963
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM004431
<309> 2004-12-20  

<400> 358
attaaggact cggggcagga ggggcagaag ttgcgcgcag gccggcgggc gggagcggac 60
accgaggccg gcgtgcaggc gtgcgggtgt gcgggagccg ggctcggggg gatcggaccg 120
agagcgagaa gcgcggcatg gagctccagg cagcccgcgc ctgcttcgcc ctgctgtggg 180
gctgtgcgct ggccgcggcc gcggcggcgc agggcaagga agtggtactg ctggactttg 240
ctgcagctgg aggggagctc ggctggctca cacacccgta tggcaaaggg tgggacctga 300
tgcagaacat catgaatgac atgccgatct acatgtactc cgtgtgcaac gtgatgtctg 360
gcgaccagga caactggctc cgcaccaact gggtgtaccg aggagaggct gagcgtatct 420
tcattgagct caagtttact gtacgtgact gcaacagctt ccctggtggc gccagctcct 480
gcaaggagac tttcaacctc tactatgccg agtcggacct ggactacggc accaacttcc 540
agaagcgcct gttcaccaag attgacacca ttgcgcccga tgagatcacc gtcagcagcg 600
acttcgaggc acgccacgtg aagctgaacg tggaggagcg ctccgtgggg ccgctcaccc 660
gcaaaggctt ctacctggcc ttccaggata tcggtgcctg tgtggcgctg ctctccgtcc 720
gtgtctacta caagaagtgc cccgagctgc tgcagggcct ggcccacttc cctgagacca 780
tcgccggctc tgatgcacct tccctggcca ctgtggccgg cacctgtgtg gaccatgccg 840
tggtgccacc ggggggtgaa gagccccgta tgcactgtgc agtggatggc gagtggctgg 900
tgcccattgg gcagtgcctg tgccaggcag gctacgagaa ggtggaggat gcctgccagg 960
cctgctcgcc tggatttttt aagtttgagg catctgagag cccctgcttg gagtgccctg 1020
agcacacgct gccatcccct gagggtgcca cctcctgcga gtgtgaggaa ggcttcttcc 1080
gggcacctca ggacccagcg tcgatgcctt gcacacgacc cccctccgcc ccacactacc 1140
tcacagccgt gggcatgggt gccaaggtgg agctgcgctg gacgccccct caggacagcg 1200
ggggccgcga ggacattgtc tacagcgtca cctgcgaaca gtgctggccc gagtctgggg 1260
aatgcgggcc gtgtgaggcc agtgtgcgct actcggagcc tcctcacgga ctgacccgca 1320
ccagtgtgac agtgagcgac ctggagcccc acatgaacta caccttcacc gtggaggccc 1380
gcaatggcgt ctcaggcctg gtaaccagcc gcagcttccg tactgccagt gtcagcatca 1440
accagacaga gccccccaag gtgaggctgg agggccgcag caccacctcg cttagcgtct 1500
cctggagcat ccccccgccg cagcagagcc gagtgtggaa gtacgaggtc acttaccgca 1560
agaagggaga ctccaacagc tacaatgtgc gccgcaccga gggtttctcc gtgaccctgg 1620
acgacctggc cccagacacc acctacctgg tccaggtgca ggcactgacg caggagggcc 1680
agggggccgg cagcaaggtg cacgaattcc agacgctgtc cccggaggga tctggcaact 1740
tggcggtgat tggcggcgtg gctgtcggtg tggtcctgct tctggtgctg gcaggagttg 1800
gcttctttat ccaccgcagg aggaagaacc agcgtgcccg ccagtccccg gaggacgttt 1860
acttctccaa gtcagaacaa ctgaagcccc tgaagacata cgtggacccc cacacatatg 1920
aggaccccaa ccaggctgtg ttgaagttca ctaccgagat ccatccatcc tgtgtcactc 1980
ggcagaaggt gatcggagca ggagagtttg gggaggtgta caagggcatg ctgaagacat 2040
cctcggggaa gaaggaggtg ccggtggcca tcaagacgct gaaagccggc tacacagaga 2100
agcagcgagt ggacttcctc ggcgaggccg gcatcatggg ccagttcagc caccacaaca 2160
tcatccgcct agagggcgtc atctccaaat acaagcccat gatgatcatc actgagtaca 2220
tggagaatgg ggccctggac aagttccttc gggagaagga tggcgagttc agcgtgctgc 2280
agctggtggg catgctgcgg ggcatcgcag ctggcatgaa gtacctggcc aacatgaact 2340
atgtgcaccg tgacctggct gcccgcaaca tcctcgtcaa cagcaacctg gtctgcaagg 2400
tgtctgactt tggcctgtcc cgcgtgctgg aggacgaccc cgaggccacc tacaccacca 2460
gtggcggcaa gatccccatc cgctggaccg ccccggaggc catttcctac cggaagttca 2520
cctctgccag cgacgtgtgg agctttggca ttgtcatgtg ggaggtgatg acctatggcg 2580
agcggcccta ctgggagttg tccaaccacg aggtgatgaa agccatcaat gatggcttcc 2640
ggctccccac acccatggac tgcccctccg ccatctacca gctcatgatg cagtgctggc 2700
agcaggagcg tgcccgccgc cccaagttcg ctgacatcgt cagcatcctg gacaagctca 2760
ttcgtgcccc tgactccctc aagaccctgg ctgactttga cccccgcgtg tctatccggc 2820
tccccagcac gagcggctcg gagggggtgc ccttccgcac ggtgtccgag tggctggagt 2880
ccatcaagat gcagcagtat acggagcact tcatggcggc cggctacact gccatcgaga 2940
aggtggtgca gatgaccaac gacgacatca agaggattgg ggtgcggctg cccggccacc 3000
agaagcgcat cgcctacagc ctgctgggac tcaaggacca ggtgaacact gtggggatcc 3060
ccatctgagc ctcgacaggg cctggagccc catcggccaa gaatacttga agaaacagag 3120
tggcctccct gctgtgccat gctgggccac tggggacttt atttatttct agttctttcc 3180
tccccctgca acttccgctg aggggtctcg gatgacaccc tggcctgaac tgaggagatg 3240
accagggatg ctgggctggg ccctctttcc ctgcgagacg cacacagctg agcacttagc 3300
aggcaccgcc acgtcccagc atccctggag caggagcccc gccacagcct tcggacagac 3360
atataggata ttcccaagcc gaccttccct ccgccttctc ccacatgagg ccatctcagg 3420
agatggaggg cttggcccag cgccaagtaa acagggtacc tcaagcccca tttcctcaca 3480
ctaagagggc agactgtgaa cttgactggg tgagacccaa agcggtccct gtccctctag 3540
tgccttcttt agaccctcgg gccccatcct catccctgac tggccaaacc cttgctttcc 3600
tgggcctttg caagatgctt ggttgtgttg aggtttttaa atatatattt tgtactttgt 3660
ggagagaatg tgtgtgtgtg gcagggggcc ccgccagggc tggggacaga gggtgtcaaa 3720
cattcgtgag ctggggactc agggaccggt gctgcaggag tgtcctgccc atgccccagt 3780
cggccccatc tctcatcctt ttggataagt ttctattctg tcagtgttaa agattttgtt 3840
ttgttggaca tttttttcga atcttaattt attatttttt ttatatttat tgttagaaaa 3900
tgacttattt ctgctctgga ataaagttgc agatgattca aaccgaaaaa aaaaaaaaaa 3960
aaa                                                               3963

<210> 359
<211> 5826
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM005233
<309> 2004-11-16  

<400> 359
cccgctctgc ttcagcgcac gctgaagacg gcactaggac ccagggaagt ccccgagcgg 60
ggttcgcgga aaggcagcca gactcctcct tatctccagt gtcaaacttg acatcagcct 120
gcgagcggag catggtaact tctccagcaa tcagagcgct ccccctcaca tcagtggcat 180
gcttcatgga gatatgctcc tctcactgcc ctctgcacca gcaacatgga ttgtcagctc 240
tccatcctcc tccttctcag ctgctctgtt ctcgacagct tcggggaact gattccgcag 300
ccttccaatg aagtcaatct actggattca aaaacaattc aaggggagct gggctggatc 360
tcttatccat cacatgggtg ggaagagatc agtggtgtgg atgaacatta cacacccatc 420
aggacttacc aggtgtgcaa tgtcatggac cacagtcaaa acaattggct gagaacaaac 480
tgggtcccca ggaactcagc tcagaagatt tatgtggagc tcaagttcac tctacgagac 540
tgcaatagca ttccattggt tttaggaact tgcaaggaga cattcaacct gtactacatg 600
gagtctgatg atgatcatgg ggtgaaattt cgagagcatc agtttacaaa gattgacacc 660
attgcagctg atgaaagttt cactcaaatg gatcttgggg accgtattct gaagctcaac 720
actgagatta gagaagtagg tcctgtcaac aagaagggat tttatttggc atttcaagat 780
gttggtgctt gtgttgcctt ggtgtctgtg agagtatact tcaaaaagtg cccatttaca 840
gtgaagaatc tggctatgtt tccagacacg gtacccatgg actcccagtc cctggtggag 900
gttagagggt cttgtgtcaa caattctaag gaggaagatc ctccaaggat gtactgcagt 960
acagaaggcg aatggcttgt acccattggc aagtgttcct gcaatgctgg ctatgaagaa 1020
agaggtttta tgtgccaagc ttgtcgacca ggtttctaca aggcattgga tggtaatatg 1080
aagtgtgcta agtgcccgcc tcacagttct actcaggaag atggttcaat gaactgcagg 1140
tgtgagaata attacttccg ggcagacaaa gaccctccat ccatggcttg tacccgacct 1200
ccatcttcac caagaaatgt tatctctaat ataaacgaga cctcagttat cctggactgg 1260
agttggcccc tggacacagg aggccggaaa gatgttacct tcaacatcat atgtaaaaaa 1320
tgtgggtgga atataaaaca gtgtgagcca tgcagcccaa atgtccgctt cctccctcga 1380
cagtttggac tcaccaacac cacggtgaca gtgacagacc ttctggcaca tactaactac 1440
acctttgaga ttgatgccgt taatggggtg tcagagctga gctccccacc aagacagttt 1500
gctgcggtca gcatcacaac taatcaggct gctccatcac ctgtcctgac gattaagaaa 1560
gatcggacct ccagaaatag catctctttg tcctggcaag aacctgaaca tcctaatggg 1620
atcatattgg actacgaggt caaatactat gaaaagcagg aacaagaaac aagttatacc 1680
attctgaggg caagaggcac aaatgttacc atcagtagcc tcaagcctga cactatatac 1740
gtattccaaa tccgagcccg aacagccgct ggatatggga cgaacagccg caagtttgag 1800
tttgaaacta gtccagactc tttctccatc tctggtgaaa gtagccaagt ggtcatgatc 1860
gccatttcag cggcagtagc aattattctc ctcactgttg tcatctatgt tttgattggg 1920
aggttctgtg gctataagtc aaaacatggg gcagatgaaa aaagacttca ttttggcaat 1980
gggcatttaa aacttccagg tctcaggact tatgttgacc cacatacata tgaagaccct 2040
acccaagctg ttcatgagtt tgccaaggaa ttggatgcca ccaacatatc cattgataaa 2100
gttgttggag caggtgaatt tggagaggtg tgcagtggtc gcttaaaact tccttcaaaa 2160
aaagagattt cagtggccat taagaccctg aaagttggct acacagaaaa gcagaggaga 2220
gacttcctgg gagaagcaag cattatggga cagtttgacc accccaatat cattcgactg 2280
gaaggagttg ttaccaaaag taagccagtt atgattgtca cagaatacat ggagaatggt 2340
tccttggata gtttcctacg taaacacgat gcccagttta ctgtcattca gctagtgggg 2400
atgcttcgag ggatagcatc tggcatgaag tacctgtcag acatgggcta tgttcaccga 2460
gacctcgctg ctcggaacat cttgatcaac agtaacttgg tgtgtaaggt ttctgatttc 2520
ggactttcgc gtgtcctgga ggatgaccca gaagctgctt atacaacaag aggagggaag 2580
atcccaatca ggtggacatc accagaagct atagcctacc gcaagttcac gtcagccagc 2640
gatgtatgga gttatgggat tgttctctgg gaggtgatgt cttatggaga gagaccatac 2700
tgggagatgt ccaatcagga tgtaattaaa gctgtagatg agggctatcg actgccaccc 2760
cccatggact gcccagctgc cttgtatcag ctgatgctgg actgctggca gaaagacagg 2820
aacaacagac ccaagtttga gcagattgtt agtattctgg acaagcttat ccggaatccc 2880
ggcagcctga agatcatcac cagtgcagcc gcaaggccat caaaccttct tctggaccaa 2940
agcaatgtgg atatcactac cttccgcaca acaggtgact ggcttaatgg tgtctggaca 3000
gcacactgca aggaaatctt cacgggtgtg gagtacagtt cttgtgacac aatagccaag 3060
atttccacag atgacatgaa aaaggttggt gtcaccgtgg ttgggccaca gaagaagatc 3120
atcagtagca ttaaagctct agaaacgcaa tcaaagaatg gcccagttcc cgtgtaaagc 3180
acgggacgga agtgcttctg gacggaagtg gtggctgtgg aaggcgtagc atcatcctgc 3240
agacagacaa taattctgga gatactggtg gaagttccaa gtccaataag acactcaaat 3300
atgagtacaa atgccttaaa atggaattga aaaactcttt attttcccct atcatttatt 3360
ggatgggtgg gtggggtatt tttttgtaat tgctttttta aatattagtt aatggattaa 3420
atttaattct tcagcgtaaa atggtgaaga actagcatat agccattgat cataaactga 3480
ctatcataaa atcaaaacaa gtgaaataac aaaatggaca tggtggcttt gtttaggtag 3540
agccacaaaa gaaaagactt gtaatatttt tatatacaga ggaaatctgt aacaggtatt 3600
ttgtttcttt taaagcaagc aacacagagg aatttatacc tcaaactatc tggccatatt 3660
tactacctta tcactgcatt attctctttt atctgtttaa agcatataga gatgaagttt 3720
gtagttgttt taagtactac acatttttaa attgttagct tccttaagta tatcatgtaa 3780
agaaatgtct taatttttga aaaaagtaca tatttatttt cttttgaatt gtttttattg 3840
ttttctattt atgccttgat gatttaatat ggatttgtta cagccaagtg ccaaatgctc 3900
tctcaaattg tcagcaattt aactagacac agataataat gggtttcttt cagatttttt 3960
gaaccatcca cttacatata tttttaaaaa atgaaatcct tttcctgttc atacactaac 4020
caaatctctc aaatctgtta tcccaatcat tgttgcctct ccgtttatta taaactgtat 4080
gctcacaact tagtgtaata taccagcttg tatgcaatgg attttcaacc agataacata 4140
cctttcctgc tctggtgctt agagactatc aactccctcc tttagtgaag gagccgtgtt 4200
agagcttccg agaatagctc cactggagag aagtggaatc ctatatagaa tgctgcacta 4260
attgacaaca cagcctatag gccaatgcat gagtaaaaaa aaaaacaatt actggctcac 4320
tggctttgaa aagtcactta ctattgttgc tgaaacttgc tgagctgttt atagagaatg 4380
atgataacag aacttttcct ctgtatcact ggtgtttagg tgaattaatt aaacattgtg 4440
atcattagta ccaggtatta ttatctttaa gagtcttcca cttcaatgca catggtgcag 4500
ttttggtgtg taacttagaa ggattgaact tctttgaatt tactggacat aacattttca 4560
gaatagttgg tcatctagca accgcctcaa aatgtgtaag caggagagaa atttctcatc 4620
acagggattt agacttacta ttacataaag gctaactatg agcttgctca ttaattttga 4680
aaagatgtac ctggtggata tctagctagt aatatattct gaagcaacat tttagctcta 4740
ttgatactct ttctaatgct gatatgatct tgagtataag aaatgcatat gtcactagaa 4800
tggataaaat aatgctgcaa acttaatgtt cttatgcaaa atggaacgct aatgaaacac 4860
agcttacaat cgcaaatcaa aactcacaag tgctcatctg ttgtagattt agtgtaataa 4920
gacttagatt gtgctccttc ggatatgatt gtttctcaaa tcttggcaat attccttagt 4980
caaatcaggc tactagaatt ctgtattgga tatataagag catgaaattt ttaaaaatac 5040
acttgtgatt ataaaattaa tcacaaattt cacttatacc tgctatcagc agctagaaaa 5100
catttttttt ttaaatcaag tattttgtgt ttggaatgtt agaatgagat ctgaatgtgg 5160
tttcaatcta attttttccc agactactat tttctttttt aggtactatt ctgagcatac 5220
tcaacaaaac ccatgcattt cataaactaa tagaagttga ggattgttga atctatttca 5280
cttattttgg ctgtggtttc catctgaaag tagaggttgt atacaccata tactgttctt 5340
cattttatta atatttttct ccttgacctc tcataaattt actttacaca attcttaccc 5400
tgtacatatg taaacataag tgtacgattc ttaaccatgg agtagaggta ctagaatgct 5460
tacggccatc tctttgtaca ggaactgcat tgactttcag taaacataaa gccacaactc 5520
ctacatgatg ttatgtacca tatgatctgt tttgtatctt aaatttgatt tacatatatt 5580
atttatttct ggtaactcac tcagtttatg ctgtgctaaa tatcaatcaa gccatgtata 5640
aatgtgatat gattggcaat atgtgtttac tttaaacttg tcttttcaaa atattactca 5700
gtttatgttg tacaatgtag atggcctctt actaatgtaa aatgatttgt agtggaaaca 5760
tttatatttt tataataaac ataatgaaaa tattttttac agattggaaa aaaaaaaaaa 5820
aaaaaa                                                            5826

<210> 360
<211> 6364
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM004438
<309> 2004-11-16  

<400> 360
ctgggataga agcggcagga gcagcgttgg caccggcgaa ccatggctgg gattttctat 60
ttcgccctat tttcgtgtct cttcgggatt tgcgacgctg tcacaggttc cagggtatac 120
cccgcgaatg aagttacctt attggattcc agatctgttc agggagaact tgggtggata 180
gcaagccctc tggaaggagg gtgggaggaa gtgagtatca tggatgaaaa aaatacacca 240
atccgaacct accaagtgtg caatgtgatg gaacccagcc agaataactg gctacgaact 300
gattggatca cccgagaagg ggctcagagg gtgtatattg agattaaatt caccttgagg 360
gactgcaata gtcttccggg cgtcatgggg acttgcaagg agacgtttaa cctgtactac 420
tatgaatcag acaacgacaa agagcgtttc atcagagaga accagtttgt caaaattgac 480
accattgctg ctgatgagag cttcacccaa gtggacattg gtgacagaat catgaagctg 540
aacaccgaga tccgggatgt agggccatta agcaaaaagg ggttttacct ggcttttcag 600
gatgtggggg cctgcatcgc cctggtatca gtccgtgtgt tctataaaaa gtgtccactc 660
acagtccgca atctggccca gtttcctgac accatcacag gggctgatac gtcttccctg 720
gtggaagttc gaggctcctg tgtcaacaac tcagaagaga aagatgtgcc aaaaatgtac 780
tgtggggcag atggtgaatg gctggtaccc attggcaact gcctatgcaa cgctgggcat 840
gaggagcgga gcggagaatg ccaagcttgc aaaattggat attacaaggc tctctccacg 900
gatgccacct gtgccaagtg cccaccccac agctactctg tctgggaagg agccacctcg 960
tgcacctgtg accgaggctt tttcagagct gacaacgatg ctgcctctat gccctgcacc 1020
cgtccaccat ctgctcccct gaacttgatt tcaaatgtca acgagacatc tgtgaacttg 1080
gaatggagta gccctcagaa tacaggtggc cgccaggaca tttcctataa tgtggtatgc 1140
aagaaatgtg gagctggtga ccccagcaag tgccgaccct gtggaagtgg ggtccactac 1200
accccacagc agaatggctt gaagaccacc aaagtctcca tcactgacct cctagctcat 1260
accaattaca cctttgaaat ctgggctgtg aatggagtgt ccaaatataa ccctaaccca 1320
gaccaatcag tttctgtcac tgtgaccacc aaccaagcag caccatcatc cattgctttg 1380
gtccaggcta aagaagtcac aagatacagt gtggcactgg cttggctgga accagatcgg 1440
cccaatgggg taatcctgga atatgaagtc aagtattatg agaaggatca gaatgagcga 1500
agctatcgta tagttcggac agctgccagg aacacagata tcaaaggcct gaaccctctc 1560
acttcctatg ttttccacgt gcgagccagg acagcagctg gctatggaga cttcagtgag 1620
cccttggagg ttacaaccaa cacagtgcct tcccggatca ttggagatgg ggctaactcc 1680
acagtccttc tggtctctgt ctcgggcagt gtggtgctgg tggtaattct cattgcagct 1740
tttgtcatca gccggagacg gagtaaatac agtaaagcca aacaagaagc ggatgaagag 1800
aaacatttga atcaaggtgt aagaacatat gtggacccct ttacgtacga agatcccaac 1860
caagcagtgc gagagtttgc caaagaaatt gacgcatcct gcattaagat tgaaaaagtt 1920
ataggagttg gtgaatttgg tgaggtatgc agtgggcgtc tcaaagtgcc tggcaagaga 1980
gagatctgtg tggctatcaa gactctgaaa gctggttata cagacaaaca gaggagagac 2040
ttcctgagtg aggccagcat catgggacag tttgaccatc cgaacatcat tcacttggaa 2100
ggcgtggtca ctaaatgtaa accagtaatg atcataacag agtacatgga gaatggctcc 2160
ttggatgcat tcctcaggaa aaatgatggc agatttacag tcattcagct ggtgggcatg 2220
cttcgtggca ttgggtctgg gatgaagtat ttatctgata tgagctatgt gcatcgtgat 2280
ctggccgcac ggaacatcct ggtgaacagc aacttggtct gcaaagtgtc tgattttggc 2340
atgtcccgag tgcttgagga tgatccggaa gcagcttaca ccaccagggg tggcaagatt 2400
cctatccggt ggactgcgcc agaagcaatt gcctatcgta aattcacatc agcaagtgat 2460
gtatggagct atggaatcgt tatgtgggaa gtgatgtcgt acggggagag gccctattgg 2520
gatatgtcca atcaagatgt gattaaagcc attgaggaag gctatcggtt accccctcca 2580
atggactgcc ccattgcgct ccaccagctg atgctagact gctggcagaa ggagaggagc 2640
gacaggccta aatttgggca gattgtcaac atgttggaca aactcatccg caaccccaac 2700
agcttgaaga ggacagggac ggagagctcc agacctaaca ctgccttgtt ggatccaagc 2760
tcccctgaat tctctgctgt ggtatcagtg ggcgattggc tccaggccat taaaatggac 2820
cggtataagg ataacttcac agctgctggt tataccacac tagaggctgt ggtgcacgtg 2880
aaccaggagg acctggcaag aattggtatc acagccatca cgcaccagaa taagattttg 2940
agcagtgtcc aggcaatgcg aacccaaatg cagcagatgc acggcagaat ggttcccgtc 3000
tgagccagta ctgaataaac tcaaaactct tgaaattagt ttacctcatc catgcacttt 3060
aattgaagaa ctgcactttt tttacttcgt cttcgccctc tgaaattaaa gaaatgaaaa 3120
aaaaaaacaa tatctgcagc gttgcttggt gcacagattg ctgaaactgt ggggcttaca 3180
gaaatgactg ccggtcattt gaatgagacc tggaacaaat cgtttctcag aagtactttt 3240
ctgttcatca ccagtctgta aaatacatgt acctatagaa atagaacact gcctctgagt 3300
tttgatgctg tatttgctgc cagacactga gcttctgaga catccctgat tctctctcca 3360
tttggaatta caaccattgt attttgtttg tggcataaat tacagtcatc tgtctttcac 3420
tggaatgaag accatgccta ggaacatttt ttaaggactc agctgtggct tttagggctt 3480
ggttcatacc atgggggaaa aaaaagtcct aggagaaagc gacgtggctc attagtgttg 3540
cctcttcagt gctcaagccg cctggtggat tcctatgaca cagggggcct ggaaagaaag 3600
ggaaagtgga tttaaaatat atatatacgt aacccaagcc ccataacccc taactggaca 3660
aatgaggtct gtttctttgg gcctgaggct gtgccatata aagtcttatt ttgggacttt 3720
acaaacttgt cctaactatc ttgtggatag tgggctgtga caatctggaa tagagaacgt 3780
tcacacttcg ctcctttaaa gaagcgaccc cagatctgca agggagtaga ttctgctatc 3840
ttggcctcac agcccttcct gttgattaca aagcccgtgg aagaaaacag aacacaccct 3900
cctcagttcc gtctaaatgt gtttcttctg cttcaattac accagttctg gggcaaagac 3960
actgatgaaa caacacccat acctgaaaag aataaatgtg tgactttcaa atcccctttc 4020
gcagtgaaag aaacagcaaa cacttaagat tcagcatctg ttctccagtt gcactgagga 4080
atgcactgtc tcgcagcacc agctctgcag agcccttgcc ccagactctt tgcggtttta 4140
tttatatgta tttccatatt tcattcctgt gtgtcactgc tgcattggtg tggcagcaag 4200
tgaccaaatg ctacaggtct tactatggac accaggtcag gtgcaaccac acaaaacaaa 4260
gccagttcca tgagctgcct atgatatgca ttgcggaagt aacattttac ccagggtgtg 4320
ccattgcagt gatataaata tatttttttc ttagactaaa tatgagctga ctatctcttt 4380
tgatgtgtgt acataggtgt gagtgtgtgt gtatgcgtgc ctgtctgtgt gcgggtgtgt 4440
gtatgtgcat agcctcatgc ttaggactac ccatgaatgt tgtggaatgc tacacctgga 4500
gagttctggt tttccaccag tttcaagatg aagaactaca tgatacagtg gacctggaga 4560
ccatcccctt ggaaagacaa cccagagatg ttcagcatcc tgtatctaca cgcatcctgt 4620
atctacacgt gtattttgta gctgtcacac taaccttaat aagaattcta cagctttgga 4680
cagaggcatt ttcaccttaa tggtgaagta atttaaaata taaatccatt caggtgacaa 4740
cccatcatca aaattacaaa ttttctgatt gaactcatct gaatcatcag ttccttgatg 4800
gagagagaga aggagatgga atgtgtctgg taaccccaaa tggagtacaa gtagcctttg 4860
ttttcctgca taaatggact tgttgaatgc gaacgaatat atgcaattca tatacttttg 4920
gagatgaacg tagatatgtg tgtcagcttt gagatggtgt gtcctggatt aatactttgt 4980
ctcccaatat cacagaaaaa tacatgccag tgactcttga ggttaaggta gttgggatga 5040
aatggcctca ggcaatttca cattccctaa ttacctggaa agttctacag taattaatat 5100
gcagctaact cctgttgccc tcacaagagc atcagccttc tagaatcgga gctccggagt 5160
gtgaagattc agtattgata tgatatgtat accaaactcc agccaactta ctgccatttt 5220
tcataatctg agtggctgcc ttgcttatcc taagctgtgg ttgcagaaac cgtggccatt 5280
tatataagct ataacatcaa atcagggaaa aatgaggaaa aaaaatagat tctgaaccat 5340
ttattgttga ataagtagag aaaatcatca ataaatattt attacattct gacagggtgt 5400
gtggcattgt gttctatgcc agagtgacaa agttgattca cccctttttg gggaccttaa 5460
tatatttttt aagggatgtg cctatgcatt gatgcctgaa aaatatgtat aaagaaatga 5520
ggttgactct tctgagcagt tcatcttttc cagaggtaag ggtaggaggc caacttcagg 5580
gtctgggtct gagcccgtgg gcaagccctg gccgagtgag ctccaatgct aactcatgtg 5640
ccgatctcta gagcagtggg aaactacccc gctgcaccaa atcaagtagc ttcaccttgt 5700
gtatgcaggc cccaagttat tttttagcaa tcttacgagt gaaatgttct ggtgggttga 5760
aaaacgttct tattttaaag aaaggttgtg ctcgctacac tgctggtgtg tgcattctga 5820
gacctcttgt attcaatctg tgaaggatat gtgtattaat ccgtacaccc gtatagcctc 5880
aatatttgtc tgaagacact taaattctga cccataaagg aaagttctag aagcaatatt 5940
ttcacttatt taacattctc caaacaacat caagcattga tacacactga agagtgcgtt 6000
tattttttgt atcactctaa gtatgttgga atatgcaagg actgtggttc aaattagaat 6060
gtataaggca tattataatt tagttcatac tgaataagaa attaacagaa cattgttcgg 6120
ttcacacgtt ccaaactttg agtgatttct ggagttagac atagattttc tattttgttt 6180
taatttgtca aggtattttt cttcccttca tgaactttag gtacacataa cttatgtcat 6240
ttatttatgg tcttttatac ctagtttgta aaattgtaaa atagcaaact aaatgcaaag 6300
agtttgcatt tgaaaataat aaagtagttg ccgtatacaa ccctgcaaaa aaaaaaaaaa 6360
aaaa                                                              6364

<210> 361
<211> 3162
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. L36644
<309> 1995-08-10  

<400> 361
ccagcgtccc tggccggctg ctactctgca cctcgacggg ctcccctctg gacgtgcctt 60
ctcctgtgcg ccgcactccg gaccctcctg gccagcccca gcaacgaagt gaatttattg 120
gattcacgca ctgtcatggg ggacctggga tggattgctt ttccaaaaaa tgggtgggaa 180
gagattggtg aagtggatga aaattatgcc cctatccaca cataccaagt atgcaaagtg 240
atggaacaga atcagaataa ctggcttttg accagttgga tctccaatga aggtgcttcc 300
agaatcttca tagaactcaa atttaccctg cgggactgca acagccttcc tggaggactg 360
gggacctgta aggaaacctt taatatgtat tactttgagt cagatgatca gaatgggaga 420
aacatcaagg aaaaccaata catcaaaatt gataccattg ctgccgatga aagctttaca 480
gaacttgatc ttggtgaccg tgttatgaaa ctgaatacag aggtcagaga tgtaggacct 540
ctaagcaaaa agggatttta tcttgctttt caagatgttg gtgcttgcat tgctctggtt 600
tctgtgcgtg tatactataa aaaatgccct tctgtggtac gacacttggc tgtcttccct 660
gacaccatca ctggagctga ttcttcccaa ttgctcgaag tgtcaggctc ctgtgtcaac 720
cattctgtga ccgatgaacc tcccaaaatg cactgcagcg ccgaagggga gtggctggtg 780
cccatcggga aatgcatgtg caaggcagga tatgaagaga aaaatggcac ctgtcaagtg 840
tgcagacctg ggttcttcaa agcctcacct cacatccaga gctgcggcaa atgtccacct 900
cacagttata cccatgagga agcttcaacc tcttgtgtct gtgaaaagga ttatttcagg 960
agagagtctg atccacccac aatggcatgc acaagacccc cctctgctcc tcggaatgcc 1020
atctcaaatg ttaatgaaac tagtgtcttt ctggaatgga ttccgcctgc tgacactggt 1080
ggaaggaaag acgtgtcata ttatattgca tgcaagaagt gcaactccca tgcaggtgtg 1140
tgtgaggagt gtggcggtca tgtcaggtac cttccccggc aaagcggcct gaaaaacacc 1200
tctgtcatga tggtggatct actcgctcac acaaactata cctttgagat tgaggcagtg 1260
aatggagtgt ccgacttgag cccaggagcc cggcagtatg tgtctgtaaa tgtaaccaca 1320
aatcaagcag ctccatctcc agtcaccaat gtgaaaaaag ggaaaattgc aaaaaacagc 1380
atctctttgt cttggcaaga accagatcgt cccaatggaa tcatcctaga gtatgaaatc 1440
aagcattttg aaaaggacca agagaccagc tacacgatta tcaaatctaa agagacaact 1500
attactgcag agggcttgaa accagcttca gtttatgtct tccaaattcg agcacgtaca 1560
gcagcaggct atggtgtctt cagtcgaaga tttgagtttg aaaccacccc agtgtttgca 1620
gcatccagcg atcaaagcca gattcctgta attgctgtgt ctgtgacagt aggagtcatt 1680
ttgttggcag tggttatcgg cgtcctcctc agtggaaggc ggtgtggcta cagcaaagca 1740
aaacaagatc cagaagagga aaagatgcat tttcataatg ggcacattaa actgccagga 1800
gtaagaactt acattgatcc acatacctat gaggatccca atcaagctgt ccacgaattt 1860
gccaaggaga tagaagcatc atgtatcacc attgagagag ttattggagc aggtgaattt 1920
ggtgaagttt gtagtggacg tttgaaacta ccaggaaaaa gagaattacc tgtggctatc 1980
aaaaccctta aagtaggcta tactgaaaag caacgcagag atttcctagg tgaagcaagt 2040
atcatgggac agtttgatca tcctaacatc atccatttag aaggtgtggt gaccaaaagt 2100
aaaccagtga tgatcgtgac agagtatatg gagaatggct ctttagatac atttttgaag 2160
aaaaacgatg ggcagttcac tgtgattcag cttgttggca tgctgagagg tatctctgca 2220
ggaatgaagt acctttctga catgggctat gtgcatagag atcttgctgc cagaaacatc 2280
ttaatcaaca gtaaccttgt gtgcaaagtg tctgactttg gactttcccg ggtactggaa 2340
gatgatcccg aggcagccta caccacaagg ggaggaaaaa ttccaatcag atggactgcc 2400
ccagaagcaa tagctttccg aaagtttact tctgccagtg atgtctggag ttatggaata 2460
gtaatgtggg aagttgtgtc ttatggagag agaccctact gggagatgac caatcaagat 2520
gtgattaaag cggtagagga aggctatcgt ctgccaagcc ccatggattg tcctgctgct 2580
ctctatcagt taatgctgga ttgctggcag aaagagcgaa atagcaggcc caagtttgat 2640
gaaatagtca acatgttgga caagctgata cgtaacccaa gtagtctgaa gacgctggtt 2700
aatgcatcct gcagagtatc taatttattg gcagaacata gcccactagg atctggggcc 2760
tacagatcag taggtgaatg gctagaggca atcaagatgg gccggtatac agagattttc 2820
atggaaaatg gatacagttc aatggacgct gtggctcagg tgaccttgga ggatttgaga 2880
cggcttggag tgactcttgt cggtcaccag aagaagatca tgaacagcct tcaagaaatg 2940
aaggtgcagc tggtaaacgg aatggtgcca ttgtaacttc atgtaaatgt cgcttcttca 3000
agtgaatgat tctgcacttt gtaaacagca ctgagattta ttttaacaaa aaaaggggga 3060
aaagggaaaa cagtgatttc taaaccttag aaaacatttg cctcagccac agaatttgta 3120
atcatggttt tactgaagta tccagttctt agtccttagt ct                    3162

<210> 362
<211> 1619
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. AL133666
<309> 2005-01-20  

<400> 362
aggaaagcta agacaaacaa aactacaatg gaagaagaaa acgtcctcaa ctagacatct 60
gccaaaaata tcatccagaa tgccctggca agttcacttc catttagtga agtgagataa 120
tttggcaatt cacgcaagag actgagaacc aagcctcaag ccctgcctct gattctgcag 180
gtatggaaca tgagcagctg acctactctt ccacaaggtc caaagccccc agtgtcatca 240
tcacaggtct taagccagcc accaaatatg tatttcacat ccgagtgaga actgcgacag 300
gatacagtgg ctacagtcag aaatttgaat ttgaaacagg agatgaaaga ctctccattt 360
caagtgacaa aactgtactg gcttaatgaa aagtgggact ttattgcctc agcttctgac 420
atggcagcag aacaaggaca gattctcgtg atagccaccg ccgctgttgg cggattcact 480
ctcctcgtca tcctcacttt attcttcttg atcactggga gatgtcagtg gtacataaaa 540
gccaagatga agtcagaaga gaagagaaga aaccacttac agaatgggca tttgcgcttc 600
ccgggaatta aaacttacat tgatccagat acatatgaag acccatccct agcagtccat 660
gaatttgcaa aggagattga tccctcaaga attcgtattg agagagtcat tggggcaggt 720
gaatttggag aagtctgtag tgggcgtttg aagacaccag ggaaaagaga gatcccagtt 780
gccattaaaa ctttgaaagg tggccacatg gatcggcaaa gaagagattt tctaagagaa 840
gctagtatca tgggccagtt tgaccatcca aacatcattc gcctagaagg ggttgtcacc 900
aaaagatcct tcccggccat tggggtggag gcgttttgcc ccagcttcct gagggcaggg 960
tttttaaata gcatccaggc cccgcatcca gtgccagggg gaggatcttt gccccccagg 1020
attcctgctg gcagaccagt aatgattgtg gtggaatata tggagaatgg atccctagac 1080
tcctttttgc ggaagcatga tggccacttc acagtcatcc agttggtcgg aatgctccga 1140
ggcattgcat caggcatgaa gtatctttct gatatgggtt atgttcatcg agacctagcg 1200
gctcggaata tactggtcaa tagcaactta gtatgcaaag tttctgattt tggtctctcc 1260
agagtgctgg aagatgatcc agaagctgct tatacaacaa ctgacctctt ccaaactcta 1320
acacttaacc tctgctattc tgcataaatt ctgagaaaag ccaaattttc tgtcggtcta 1380
agaagacata gcctacaccc aactggagat aattataaaa aataatgaag cagcatgagg 1440
ggaaggtatt taatgtgtat tttaaagttg ggagagattc tccttcacct aatttaggtg 1500
tttgtgaatt ggcttgactt tttgaagtta atttttaagc cttgaacatg tccaacttta 1560
agaactttaa gaataaatat tttaacacaa gtgaaaaaaa aaaaaaaaaa aaaaaaagg  1619

<210> 363
<211> 4996
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM004440
<309> 2005-01-26  

<400> 363
gcgccggggt gtgcgcccgg ccgggtgtgc ggagagcgag ggagcgcgct ccctcccgac 60
gcgcgggccg cagcggccaa gcccgagggt gcgtggcgcc cccgcccgcc cggcccggcc 120
cggccatggc ccccgcccgg ggccgcctgc cccctgcgct ctgggtcgtc acggccgcgg 180
cggcggcggc cacctgcgtg tccgcggcgc gcggcgaagt gaatttgctg gacacgtcga 240
ccatccacgg ggactggggc tggctcacgt atccggctca tgggtgggac tccatcaacg 300
aggtggacga gtccttccag cccatccaca cgtaccaggt ttgcaacgtc atgagcccca 360
accagaacaa ctggctgcgc acgagctggg tcccccgaga cggcgcccgg cgcgtctatg 420
ctgagatcaa gtttaccctg cgcgactgca acagcatgcc tggtgtgctg ggcacctgca 480
aggagacctt caacctctac tacctggagt cggaccgcga cctgggggcc agcacacaag 540
aaagccagtt cctcaaaatc gacaccattg cggccgacga gagcttcaca ggtgccgacc 600
ttggtgtgcg gcgtctcaag ctcaacacgg aggtgcgcag tgtgggtccc ctcagcaagc 660
gcggcttcta cctggccttc caggacatag gtgcctgcct ggccatcctc tctctccgca 720
tctactataa gaagtgccct gccatggtgc gcaatctggc tgccttctcg gaggcagtga 780
cgggggccga ctcgtcctca ctggtggagg tgaggggcca gtgcgtgcgg cactcagagg 840
agcgggacac acccaagatg tactgcagcg cggagggcga gtggctcgtg cccatcggca 900
aatgcgtgtg cagtgccggc tacgaggagc ggcgggatgc ctgtgtggcc tgtgagctgg 960
gcttctacaa gtcagcccct ggggaccagc tgtgtgcccg ctgccctccc cacagccact 1020
ccgcagctcc agccgcccaa gcctgccact gtgacctcag ctactaccgt gcagccctgg 1080
acccgccgtc ctcagcctgc acccggccac cctcggcacc agtgaacctg atctccagtg 1140
tgaatgggac atcagtgact ctggagtggg cccctcccct ggacccaggt ggccgcagtg 1200
acatcaccta caatgccgtg tgccgccgct gcccctgggc actgagccgc tgcgaggcat 1260
gtgggagcgg cacccgcttt gtgccccagc agacaagcct ggtgcaggcc agcctgctgg 1320
tggccaacct gctggcccac atgaactact ccttctggat cgaggccgtc aatggcgtgt 1380
ccgacctgag ccccgagccc cgccgggccg ctgtggtcaa catcaccacg aaccaggcag 1440
ccccgtccca ggtggtggtg atccgtcaag agcgggcggg gcagaccagc gtctcgctgc 1500
tgtggcagga gcccgagcag ccgaacggca tcatcctgga gtatgagatc aagtactacg 1560
agaaggacaa ggagatgcag agctactcca ccctcaaggc cgtcaccacc agagccaccg 1620
tctccggcct caagccgggc acccgctacg tgttccaggt ccgagcccgc acctcagcag 1680
gctgtggccg cttcagccag gccatggagg tggagaccgg gaaaccccgg ccccgctatg 1740
acaccaggac cattgtctgg atctgcctga cgctcatcac gggcctggtg gtgcttctgc 1800
tcctgctcat ctgcaagaag aggcactgtg gctacagcaa ggccttccag gactcggacg 1860
aggagaagat gcactatcag aatggacagg cacccccacc tgtcttcctg cctctgcatc 1920
accccccggg aaagctccca gagccccagt tctatgcgga accccacacc tacgaggagc 1980
caggccgggc gggccgcagt ttcactcggg agatcgaggc ctctaggatc cacatcgaga 2040
aaatcatcgg ctctggagac tccggggaag tctgctacgg gaggctgcgg gtgccagggc 2100
agcgggatgt gcccgtggcc atcaaggccc tcaaagccgg ctacacggag agacagaggc 2160
gggacttcct gagcgaggcg tccatcatgg ggcaattcga ccatcccaac atcatccgcc 2220
tcgagggtgt cgtcacccgt ggccgcctgg caatgattgt gactgagtac atggagaacg 2280
gctctctgga caccttcctg aggacccacg acgggcagtt caccatcatg cagctggtgg 2340
gcatgctgag aggagtgggt gccggcatgc gctacctctc agacctgggc tatgtccacc 2400
gagacctggc cgcccgcaac gtcctggttg acagcaacct ggtctgcaag gtgtctgact 2460
tcgggctctc acgggtgctg gaggacgacc cggatgctgc ctacaccacc acgggcggga 2520
agatccccat ccgctggacg gccccagagg ccatcgcctt ccgcaccttc tcctcggcca 2580
gcgacgtgtg gagcttcggc gtggtcatgt gggaggtgct ggcctatggg gagcggccct 2640
actggaacat gaccaaccgg gatgtcatca gctctgtgga ggaggggtac cgcctgcccg 2700
cacccatggg ctgcccccac gccctgcacc agctcatgct cgactgttgg cacaaggacc 2760
gggcgcagcg gcctcgcttc tcccagattg tcagtgtcct cgatgcgctc atccgcagcc 2820
ctgagagtct cagggccacc gccacagtca gcaggtgccc accccctgcc ttcgtccgga 2880
gctgctttga cctccgaggg ggcagcggtg gcggtggggg cctcaccgtg ggggactggc 2940
tggactccat ccgcatgggc cggtaccgag accacttcgc tgcgggcgga tactcctctc 3000
tgggcatggt gctacgcatg aacgcccagg acgtgcgcgc cctgggcatc accctcatgg 3060
gccaccagaa gaagatcctg ggcagcattc agaccatgcg ggcccagctg accagcaccc 3120
aggggccccg ccggcacctc tgatgtacag ccagcagggc ccaggcagcc accaagccca 3180
ccccaggtca tgccagcggc agaggacgtg aggggctggc agcaggcagg gcggccccag 3240
gcctctgccc tcctctcagg tgctggagga gctgaaggct tcgccacagg acctggagtt 3300
atcaggggtc aggcgcctgg gaaggggcct ttggtggcca ccctggtgag gacacctgtc 3360
ccccagggca ggcaccttct cttttccaga gcctggggcc tccacgtcac agagtccaac 3420
agggacatca ctcgcctgcc tctgtgtgcg tgcatgtgtg tgtgtggtgg ggggtgttct 3480
cacaaggtca tgggatctca tgtgaacagt gtgtgatcaa gtgtgtccac cccttcgggt 3540
ctcagcatgg acgtgtgcat gttatgagcg tgtgcttatc cgttaaggct ggaggcacat 3600
gtgggtgatg gtggatgatg tgtcatgaat gaggaggtgt gtgagcaggg aactcagtgt 3660
gacaccgcca ggtccagcac ccatgggggc gggggagagg ctcaccccta cgtcccccca 3720
cacctggagg ctggagccag gggccacttc tgaactgcac cagcaccagg cccaccctcg 3780
tctctgcctg ggtgagccca ccccggctgt atctcaggtc tgggtcctcc ctctagccga 3840
ggaggccacc tgcagcctcc acccggctct caccgctgct tcaacaggaa aacagggttc 3900
ccggtcagtc cggctggccg ccttcatgga ggcatcatgg cagagcacat gagatgtcct 3960
cagctgggct tggctgcctg gccagggccg ggggctcagc agcctcctct agcctctgat 4020
gccttccctc cacggcccag gtctcctcac tcaaagtccc ttcgccaacc tttcaatgcc 4080
cagccctgac acctgccctt tgtcccccag gcctaggatc agggaccaga ggatcctatc 4140
ttctcagcac ccagcccacc ccttcctgta gcatatgggg agactaaggc ctggagagag 4200
gggtgatgcc ccgtcccagg ttgcactgca accaagtgtc agagtcgggg ctccggcctc 4260
ctgccaaggc tcttgtcccc atacaccatc ccacaagggc gctgggggtg gaagtgccct 4320
ggaagcccct cccctctcac actgacctcc ccccttacgg cccaccaggg tatgtaaata 4380
tctcttttct accatgtcag aatatttttt cctcactcct gacaatgcaa aaatggtctt 4440
caaagcacat aaaaagcacc cagggtgaga aagccccatc ccgggggccg ttggcaggca 4500
gggaagcagg aaccccaccg tgtgccccct gccagcccca gagggagtgg cgagcccagc 4560
tgcccagccc tgccccccct ccccatagcc agcacagcta tcccgcgggg acaccagcac 4620
tgagccccct ctccctcctg caataattcg gggagtctca gccccatcca ggtgccgcgg 4680
ccagctctct acacctctat atattatatt actatatagc cgagctgttc ttccttccta 4740
tggaagtcgg aaacatggtc agaacacgat ctgggggggg gatcctgtct tcctccccac 4800
cccaccccac tcttacccaa tttctgggct ctggatcctc acagtcatgg aggcaccgtg 4860
ggcctggcac ttgcaaaagt gtggcccctc actctagtgt gtggtccctc tcagggtcct 4920
ggggatctgc ctctctgtgg tctccatcct gactcttgaa cttacccaca ataagaataa 4980
attctgcctc atcttt                                                 4996

<210> 364
<211> 5229
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM020526
<309> 2004-11-16  

<400> 364
gcagtcggag acttgcaggc agcaaacacg gtgcgagcga acaggagtgg gggggaaatt 60
aaaaaaagct aaacgtggag cagccgatcg gggaccgaga aggggaatcg atgcaaggag 120
cacaataaaa caaaagctac ttcggaacaa acagcattta aaaatccacg actcaagata 180
actgaaacct aaaataaaac ctgctcatgc accatggttt ttcaaactcg gtacccttca 240
tggattattt tatgctacat ctggctgctc cgctttgcac acacagggga ggcgcaggct 300
gcgaaggaag tactactgct ggattctaaa gcacaacaaa cagagttgga gtggatttcc 360
tctccaccca atgggtggga agaaattagt ggtttggatg agaactatac cccgatacga 420
acataccagg tgtgccaagt catggagccc aaccaaaaca actggctgcg gactaactgg 480
atttccaaag gcaatgcaca aaggattttt gtagaattga aattcaccct gagggattgt 540
aacagtcttc ctggagtact gggaacttgc aaggaaacat ttaatttgta ctattatgaa 600
acagactatg acactggcag gaatataaga gaaaacctct atgtaaaaat agacaccatt 660
gctgcagatg aaagttttac ccaaggtgac cttggtgaaa gaaagatgaa gcttaacact 720
gaggtgagag agattggacc tttgtccaaa aagggattct atcttgcctt tcaggatgta 780
ggggcttgca tagctttggt ttctgtcaaa gtgtactaca agaagtgctg gtccattatt 840
gagaacttag ctatctttcc agatacagtg actggttcag aattttcctc tttagtcgag 900
gttcgaggga catgtgtcag cagtgcagag gaagaagcgg aaaacgcccc caggatgcac 960
tgcagtgcag aaggagaatg gttagtgccc attggaaaat gtatctgcaa agcaggctac 1020
cagcaaaaag gagacacttg tgaaccctgt ggccgtgggt tctacaagtc ttcctctcaa 1080
gatcttcagt gctctcgttg tccaactcac agtttttctg ataaagaagg ctcctccaga 1140
tgtgaatgtg aagatgggta ttacagggct ccatctgacc caccatacgt tgcatgcaca 1200
aggcctccat ctgcaccaca gaacctcatt ttcaacatca accaaaccac agtaagtttg 1260
gaatggagtc ctcctgcaga caatggggga agaaacgatg tgacctacag aatattgtgt 1320
aagcggtgca gttgggagca gggcgaatgt gttccctgtg ggagtaacat tggatacatg 1380
ccccagcaga ctggattaga ggataactat gtcactgtca tggacctgct agcccacgct 1440
aattatactt ttgaagttga agctgtaaat ggagtttctg acttaagccg atcccagagg 1500
ctctttgctg ctgtcagtat caccactggt caagcagctc cctcgcaagt gagcggagta 1560
atgaaggaga gagtactgca gcggagtgtc gagctttcct ggcaggaacc agagcatccc 1620
aatggagtca tcacagaata tgaaatcaag tattacgaga aagatcaaag ggaacggacc 1680
tactcaacag taaaaaccaa gtctacttca gcctccatta ataatctgaa accaggaaca 1740
gtgtatgttt tccagattcg ggcttttact gctgctggtt atggaaatta cagtcccaga 1800
cttgatgttg ctacactaga ggaagctaca ggtaaaatgt ttgaagctac agctgtctcc 1860
agtgaacaga atcctgttat tatcattgct gtggttgctg tagctgggac catcattttg 1920
gtgttcatgg tctttggctt catcattggg agaaggcact gtggttatag caaagctgac 1980
caagaaggcg atgaagagct ttactttcat tttaaatttc caggcaccaa aacctacatt 2040
gaccctgaaa cctatgagga cccaaataga gctgtccatc aattcgccaa ggagctagat 2100
gcctcctgta ttaaaattga gcgtgtgatt ggtgcaggag aattcggtga agtctgcagt 2160
ggccgtttga aacttccagg gaaaagagat gttgcagtag ccataaaaac cctgaaagtt 2220
ggttacacag aaaaacaaag gagagacttt ttgtgtgaag caagcatcat ggggcagttt 2280
gaccacccaa atgttgtcca tttggaaggg gttgttacaa gagggaaacc agtcatgata 2340
gtaatagagt tcatggaaaa tggagcccta gatgcatttc tcaggaaaca tgatgggcaa 2400
tttacagtca ttcagttagt aggaatgctg agaggaattg ctgctggaat gagatatttg 2460
gctgatatgg gatatgttca cagggacctt gcagctcgca atattcttgt caacagcaat 2520
ctcgtttgta aagtgtcaga ttttggcctg tcccgagtta tagaggatga tccagaagct 2580
gtctatacaa ctactggtgg aaaaattcca gtaaggtgga cagcacccga agccatccag 2640
taccggaaat tcacatcagc cagtgatgta tggagctatg gaatagtcat gtgggaagtt 2700
atgtcttatg gagaaagacc ttattgggac atgtcaaatc aagatgttat aaaagcaata 2760
gaagaaggtt atcgtttacc agcacccatg gactgcccag ctggccttca ccagctaatg 2820
ttggattgtt ggcaaaagga gcgtgctgaa aggccaaaat ttgaacagat agttggaatt 2880
ctagacaaaa tgattcgaaa cccaaatagt ctgaaaactc ccctgggaac ttgtagtagg 2940
ccaataagcc ctcttctgga tcaaaacact cctgatttca ctaccttttg ttcagttgga 3000
gaatggctac aagctattaa gatggaaaga tataaagata atttcacggc agctggctac 3060
aattcccttg aatcagtagc caggatgact attgaggatg tgatgagttt agggatcaca 3120
ctggttggtc atcaaaagaa aatcatgagc agcattcaga ctatgagagc acaaatgcta 3180
catttacatg gaactggcat tcaagtgtga tatgcatttc tcccttttaa gggagattac 3240
agactgcaag agaacagtac tggccttcag tatatgcata gaatgctgct agaagacaag 3300
tgatgtcctg ggtccttcca acagtgaaga gaagatttaa gaagcaccta tagacttgaa 3360
ctcctaagtg ccaccagaat atataaaaag ggaatttagg atccaccatc ggtggccagg 3420
aaaatagcag tgacaataaa caaagtacta cctgaaaaac atccaaacac cttgagctct 3480
ctaacctcct ttttgtctta tagacttttt aaaatgtaca taaagaattt aagaaagaat 3540
atatttgtca aataaaatca tgatcttatt gttaaaatta atgaaatatt ttccttaaat 3600
atgtgatttc agactattcc tttttaaaat catttgtgtt tattcttcat aaggactttg 3660
ttttagaaag ctgtttatag ctttggacct ttttagtgtt aaatctgtaa cattactaca 3720
ctgggtacct ttgaaagaat ctcaaatttc aaaagaaata gcatgattga agatacatct 3780
ctgttagaac attggtatcc tttttgtgcc attttattct gtttaatcag tgctgttttg 3840
atattgtttg ctaattggca ggtagtcaag aaaatgcaag ttgccaagag ctctgatatt 3900
ttttaaaaag aatttttttg taaagatcag acaacacact atcttttcaa tgaaaaaagc 3960
aataatgatc catacatact ataaggcact tttaacagat tgtttataga gtgattttac 4020
tagaaagaat ttaataaact cgaagtttag gtttatgagt atataaacaa atgaggcact 4080
tcatctgaag aatgttggtg aaggcaagtc tctgaaagca gaactatcca gtgttatcta 4140
aaaattaatc tgagcacatc aagatttttt cattctcgtg acattaggaa atttaggata 4200
aatagttgac atatatttta tatcctcttc tgttgaatgc agtccaaaca tgaaaggaaa 4260
taattgtttt atattataac tctgaagcat gataaagggg cagttcacaa ttttcaccat 4320
ttaaacacaa atttgctgca cagaatatca ccattgcagt tcaaaacaaa acaaaacaaa 4380
aagtcttttg tttgtgaaca ctgatgcaag aaacttgtta aatgaaagga ctctttaccc 4440
tagaaggaag aggtgaagga tctggcttgt ttttaaagct ttatttatta aaccatatta 4500
tttgattact gtgttagaat ttcataagca ataattaaat gtgtctttat agatattgca 4560
ggaatgtata catattgtga ttaatgcttt caaaacttat gaaaatcatg aactacccca 4620
gaattgaact gttgtacttc caaagagaat tgggctgttt ataatgattt taatagagaa 4680
agatcccagg gatcggtcat aattggtctt gtttgataat gtgggcatcc acaaacaaac 4740
aaacaaataa cagaaacaaa atctgtaaat gttcctttgt aaaacttgta aattttattt 4800
atactgtctt gttttgtaca cacatttctc tgtagtgggc tctgaataca ttgaaaatgc 4860
actatatttt tctattttac ttgcagagca tcacaaaaga acaggtattt tcagtgctac 4920
ataatgtgtt ttcccacatt taggaccaaa gacggctata gaaaaactca aatggattgc 4980
ttcccaaacc cctccccacc cttttttttt ggttttaaat cactgtacag tgttatttga 5040
tattttaatt tattttttga ttgactagaa aaatcatttt aatttcacta aaatgttttt 5100
tgtccctaag gaaaagtaat ctgtaaaaat aattttaatt agcataatac agtcacctag 5160
acacttccat ttgtaatctt tgtaatagac tgtaaatata tttttggaac tataaaaaaa 5220
aaaaaaaaa                                                         5229

<210> 365
<211> 3865
<212> DNA
<213> Homo Sapiens

<300> 
<308> GenBank No. NM004441
<309> 2004-11-15  

<400> 365
cacatgcaca cccacaccca cgcgcgcccg caccgcccca cgcgcacaca ctcctgccca 60
cgcccacgca gcgctccggg aagtccggtc cgggcgagag cgcgaaagga taccgagaag 120
ccacccgcgg agagcgcagc ggcgccctgg gacgcggcgc tctcccggcg ctgctgcctc 180
ggcttggtct cggcctgcgg gccgtcggcc ggcgatggcc ctggattatc tactactgct 240
cctcctggca tccgcagtgg ctgcgatgga agaaacgtta atggacacca gaacggctac 300
tgcagagctg ggctggacgg ccaatcctgc gtccgggtgg gaagaagtca gtggctacga 360
tgaaaacctg aacaccatcc gcacctacca ggtgtgcaat gtcttcgagc ccaaccagaa 420
caattggctg ctcaccacct tcatcaaccg gcggggggcc catcgcatct acacagagat 480
gcgcttcact gtgagagact gcagcagcct ccctaatgtc ccaggatcct gcaaggagac 540
cttcaacttg tattactatg agactgactc tgtcattgcc accaagaagt cagccttctg 600
gtctgaggcc ccctacctca aagtagacac cattgctgca gatgagagct tctcccaggt 660
ggactttggg ggaaggctga tgaaggtaaa cacagaagtc aggagctttg ggcctcttac 720
tcggaatggt ttttacctcg cttttcagga ttatggagcc tgtatgtctc ttctttctgt 780
ccgtgtcttc ttcaaaaagt gtcccagcat tgtgcaaaat tttgcagtgt ttccagagac 840
tatgacaggg gcagagagca catctctggt gattgctcgg ggcacatgca tccccaacgc 900
agaggaagtg gacgtgccca tcaaactcta ctgcaacggg gatggggaat ggatggtgcc 960
tattgggcga tgcacctgca agcctggcta tgagcctgag aacagcgtgg catgcaaggc 1020
ttgccctgca gggacattca aggccagcca ggaagctgaa ggctgctccc actgcccctc 1080
caacagccgc tcccctgcag aggcgtctcc catctgcacc tgtcggaccg gttattaccg 1140
agcggacttt gaccctccag aagtggcatg cactagcgtc ccatcaggtc cccgcaatgt 1200
tatctccatc gtcaatgaga cgtccatcat tctggagtgg caccctccaa gggagacagg 1260
tgggcgggat gatgtgacct acaacatcat ctgcaaaaag tgccgggcag accgccggag 1320
ctgctcccgc tgtgacgaca atgtggagtt tgtgcccagg cagctgggcc tgacggagtg 1380
ccgcgtctcc atcagcagcc tgtgggccca caccccctac acctttgaca tccaggccat 1440
caatggagtc tccagcaaga gtcccttccc cccacagcac gtctctgtca acatcaccac 1500
aaaccaagcc gccccctcca ccgttcccat catgcaccaa gtcagtgcca ctatgaggag 1560
catcaccttg tcatggccac agccggagca gcccaatggc atcatcctgg actatgagat 1620
ccggtactat gagaaggaac acaatgagtt caactcctcc atggccagga gtcagaccaa 1680
cacagcaagg attgatgggc tgcggcctgg catggtatat gtggtacagg tgcgtgcccg 1740
cactgttgct ggctacggca agttcagtgg caagatgtgc ttccagactc tgactgacga 1800
tgattacaag tcagagctga gggagcagct gcccctgatt gctggctcgg cagcggccgg 1860
ggtcgtgttc gttgtgtcct tggtggccat ctctatcgtc tgtagcagga aacgggctta 1920
tagcaaagag gctgtgtaca gcgataagct ccagcattac agcacaggcc gaggctcccc 1980
agggatgaag atctacattg accccttcac ttatgaggat cccaacgaag ctgtccggga 2040
gtttgccaag gagattgatg tatcttttgt gaaaattgaa gaggtcatcg gagcagggga 2100
gtttggagaa gtgtacaagg ggcgtttgaa actgccaggc aagagggaaa tctacgtggc 2160
catcaagacc ctgaaggcag ggtactcgga gaagcagcgt cgggactttc tgagtgaggc 2220
gagcatcatg ggccagttcg accatcctaa catcattcgc ctggagggtg tggtcaccaa 2280
gagtcggcct gtcatgatca tcacagagtt catggagaat ggtgcattgg attctttcct 2340
caggcaaaat gacgggcagt tcaccgtgat ccagcttgtg ggtatgctca ggggcatcgc 2400
tgctggcatg aagtacctgg ctgagatgaa ttatgtgcat cgggacctgg ctgctaggaa 2460
cattctggtc aacagtaacc tggtgtgcaa ggtgtccgac tttggcctct cccgctacct 2520
ccaggatgac acctcagatc ccacctacac cagctccttg ggagggaaga tccctgtgag 2580
atggacagct ccagaggcca tcgcctaccg caagttcact tcagccagcg acgtttggag 2640
ctatgggatc gtcatgtggg aagtcatgtc atttggagag agaccctatt gggatatgtc 2700
caaccaagat gtcatcaatg ccatcgagca ggactaccgg ctgcccccac ccatggactg 2760
tccagctgct ctacaccagc tcatgctgga ctgttggcag aaggaccgga acagccggcc 2820
ccggtttgcg gagattgtca acaccctaga taagatgatc cggaacccgg caagtctcaa 2880
gactgtggca accatcaccg ccgtgccttc ccagcccctg ctcgaccgct ccatcccaga 2940
cttcacggcc tttaccaccg tggatgactg gctcagcgcc atcaaaatgg tccagtacag 3000
ggacagcttc ctcactgctg gcttcacctc cctccagctg gtcacccaga tgacatcaga 3060
agacctcctg agaataggca tcaccttggc aggccatcag aagaagatcc tgaacagcat 3120
tcattctatg agggtccaga taagtcagtc accaacggca atggcatgag aactcttgtt 3180
tcttggggaa ggagaggagg gaaaaggacc agggtcaagg gggaccagag gttgaccact 3240
gtggaatgta ctggagagac tggcttctca gctgaggaat gcatttccat cagtgaagaa 3300
tcaaccggac ctgttgctag caggcaatct ccatttctca gtgacagaag catgtttgag 3360
atgccgtggg aaaccaaata tataataata aaaatataaa aaggtgatgt tcaacagaag 3420
tgaagacaaa acaatatgca tcaggagaac aagagtaaac ccagctccca ctctcagtgg 3480
gctgcagttg cccaaccaca ggaagaaagg gaaggaggta gagggaagaa acagaagcag 3540
tgttccattt tcttcctcac caatgacatt cttttctttt ctcctttcgt actcctccct 3600
gagagtcccc tcccttctcc cacactcgtt tccctttgct catgactcct gtagggaagt 3660
ttcttcaaac aaaacccagc tcctgagtct ccagatgttg ttctgtcagt tgccaaagga 3720
ctttgctgac cactgcatgg ggatccaacc aattcaatta atgtcttcat attgaagaag 3780
agatgtacct tcaattgaaa acctcgtttt tcttttgttt gcattttctg caaaaaggaa 3840
aaagaaacca caaattgggg aattc                                       3865

<210> 366
<211> 3949
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. AF025304
<309> 2000-11-29  

<400> 366
gaattccgcc ccgggaagcg cagccatggc tctgcggagg ctgggggccg cgctgctgct 60
gctgccgctg ctcgccgccg tggaagaaac gctaatggac tccactacag cgactgctga 120
gctgggctgg atggtgcatc ctccatcagg gtgggaagag gtgagtggct acgatgagaa 180
catgaacacg atccgcacgt accaggtgtg caacgtgttt gagtcaagcc agaacaactg 240
gctacggacc aagtttatcc ggcgccgtgg cgcccaccgc atccacgtgg agatgaagtt 300
ttcggtgcgt gactgcagca gcatccccag cgtgcctggc tcctgcaagg agaccttcaa 360
cctctattac tatgaggctg actttgactc ggccaccaag accttcccca actggatgga 420
gaatccatgg gtgaaggtgg ataccattgc agccgacgag agcttctccc aggtggacct 480
gggtggccgc gtcatgaaaa tcaacaccga ggtgcggagc ttcggacctg tgtcccgcag 540
cggcttctac ctggccttcc aggactatgg cggctgcatg tccctcatcg ccgtgcgtgt 600
cttctaccgc aagtgccccc gcatcatcca gaatggcgcc atcttccagg aaaccctgtc 660
gggggctgag agcacatcgc tggtggctgc ccggggcagc tgcatcgcca atgcggaaga 720
ggtggatgta cccatcaagc tctactgtaa cggggacggc gagtggctgg tgcccatcgg 780
gcgctgcatg tgcaaagcag gcttcgaggc cgttgagaat ggcaccgtct gccgaggttg 840
tccatctggg actttcaagg ccaaccaagg ggatgaggcc tgtacccact gtcccatcaa 900
cagccggacc acttctgaag gggccaccaa ctgtgtctgc cgcaatggct actacagagc 960
agacctggac cccctggaca tgccctgcac aaccatcccc tccgcgcccc aggctgtgat 1020
ttccagtgtc aatgagacct ccctcatgct ggagtggacc cctccccgcg actccggagg 1080
ccgagaggac ctcgtctaca acatcatctg caagagctgt ggctcgggcc ggggtgcctg 1140
cacccgctgc ggggacaatg tacagtacgc accacgccag ctaggcctga ccgagccacg 1200
catttacatc agtgacctgc tggcccacac ccagtacacc ttcgagatcc aggctgtgaa 1260
cggcgttact gaccagagcc ccttctcgcc tcagttcgcc tctgtgaaca tcaccaccaa 1320
ccaggcagct ccatcggcag tgtccatcat gcatcaggtg agccgcaccg tggacagcat 1380
taccctgtcg tggtcccagc cagaccagcc caatggcgtg atcctggact atgagctgca 1440
gtactatgag aaggagctca gtgagtacaa cgccacagcc ataaaaagcc ccaccaacac 1500
ggtcaccgtg cagggcctca aagccggcgc catctatgtc ttccaggtgc gggcacgcac 1560
cgtggcaggc tacgggcgct acagcggcaa gatgtacttc cagaccatga cagaagccga 1620
gtaccagaca agcatccagg agaagttgcc actcatcatc ggctcctcgg ccgctggcct 1680
ggtcttcctc attgctgtgg ttgtcatcgc catcgtgtgt aacagacggg ggtttgagcg 1740
tgctgactcg gagtacacgg acaagctgca acactacacc agtggccaca tgaccccagg 1800
catgaagatc tacatcgatc ctttcaccta cgaggacccc aacgaggcag tgcgggagtt 1860
tgccaaggaa attgacatct cctgtgtcaa aattgagcag gtgatcggag caggggagtt 1920
tggcgaggtc tgcagtggcc acctgaagct gccaggcaag agagagatct ttgtggccat 1980
caagacgctc aagtcgggct acacggagaa gcagcgccgg gacttcctga gcgaagcctc 2040
catcatgggc cagttcgacc atcccaacgt catccacctg gagggtgtcg tgaccaagag 2100
cacacctgtg atgatcatca ccgagttcat ggagaatggc tccctggact cctttctccg 2160
gcaaaacgat gggcagttca cagtcatcca gctggtgggc atgcttcggg gcatcgcagc 2220
tggcatgaag tacctggcag acatgaacta tgttcaccgt gacctggctg cccgcaacat 2280
cctcgtcaac agcaacctgg tctgcaaggt gtcggacttt gggctctcac gctttctaga 2340
ggacgatacc tcagacccca cctacaccag tgccctgggc ggaaagatcc ccatccgctg 2400
gacagccccg gaagccatcc agtaccggaa gttcacctcg gccagtgatg tgtggagcta 2460
cggcattgtc atgtgggagg tgatgtccta tggggagcgg ccctactggg acatgaccaa 2520
ccaggatgta atcaatgcca ttgagcagga ctatcggctg ccaccgccca tggactgccc 2580
gagcgccctg caccaactca tgctggactg ttggcagaag gaccgcaacc accggcccaa 2640
gttcggccaa attgtcaaca cgctagacaa gatgatccgc aatcccaaca gcctcaaagc 2700
catggcgccc ctctcctctg gcatcaacct gccgctgctg gaccgcacga tccccgacta 2760
caccagcttt aacacggtgg acgagtggct ggaggccatc aagatggggc agtacaagga 2820
gagcttcgcc aatgccggct tcacctcctt tgacgtcgtg tctcagatga tgatggagga 2880
cattctccgg gttggggtca ctttggctgg ccaccagaaa aaaatcctga acagtatcca 2940
ggtgatgcgg gcgcagatga accagattca gtctgtggag ggccagccac tcgccaggag 3000
gccacgggcc acgggaagaa ccaagcggtg ccagccacga gacgtcacca agaaaacatg 3060
caactcaaac gacggaaaaa aaaagggaat gggaaaaaag aaaacagatc ctgggagggg 3120
gcgggaaata caaggaatat tttttaaaga ggattctcat aaggaaagca atgactgttc 3180
ttgcggggga taaaaaaggg cttgggagat tcatgcgatg tgtccaatcg gagacaaaag 3240
cagtttctct ccaactccct ctgggaaggt gacctggcca gagccaagaa acactttcag 3300
aaaaacaaat gtgaagggga gagacagggg ccacccttgg ctcctgtccc tgctgctcct 3360
ctaggcctca ctcaacaacc aagcgcctgg aggacgggac agatggacag acagccaccc 3420
tgagaacccc tctgggaaaa tctattcctg ccaccactgg gcaaacagaa gaatttttct 3480
gtctttggag agtattttag aaactccaat gaaagacact gtttctcctg ttggctcaca 3540
gggctgaaag gggcttttgt cctcctgggt cagggagaac gcggggaccc cagaaaggtc 3600
agccttcctg aggatgggca acccccaggt ctgcagctcc aggtacatat cacgcgcaca 3660
gcctggcagc ctggccctcc tggtgcccac tcccgccagc ccctgcctcg aggactgata 3720
ctgcagtgac tgccgtcagc tccgactgcc gctgagaagg gttgatcctg catctgggtt 3780
tgtttacagc aattcctgga ctcgggggta ttttggtcac agggtggttt tggtttaggg 3840
ggtttgtttg ttgggttgtt ttttgttttt tggttttttt taatgacaat gaagtgacac 3900
tttgacattt ccaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa             3949

<210> 367
<211> 4234
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM004443
<309> 2004-11-16  

<400> 367
cgtgagcggc gcagcaagat cccagctcgg accccggacg gcgcgcgccc ccgaagcccc 60
ggatcccagt cgggcccgca gctgaccgcc agattactgt gcatcccgaa tcacgaccac 120
ctgcaccctc ctgccccggc ccgcccccca agtcctcagg cacccagctc cccggcgccc 180
cggatcctcc tggaccggtc cgtccagatt cccgcgggac cgacctgtcc gcatccccag 240
gaccgccggg ctcggtgcac cgcctcggtc ccggagccgc ccgcctggat tgcattccct 300
cctctcctgg atctcctggg acccgacgcg agcctgcccc ggagcccgcc gagcgcaccc 360
tctctcgggt gcctgcagcc ccgccggcgc ggcccggccc ggcgcggccc ggctcggctc 420
ctagagctgc cacggccatg gccagagccc gcccgccgcc gccgccgtcg ccgccgccgg 480
ggcttctgcc gctgctccct ccgctgctgc tgctgccgct gctgctgctg cccgccggct 540
gccgggcgct ggaagagacc ctcatggaca caaaatgggt aacatctgag ttggcgtgga 600
catctcatcc agaaagtggg tgggaagagg tgagtggcta cgatgaggcc atgaatccca 660
tccgcacata ccaggtgtgt aatgtgcgcg agtcaagcca gaacaactgg cttcgcacgg 720
ggttcatctg gcggcgggat gtgcagcggg tctacgtgga gctcaagttc actgtgcgtg 780
actgcaacag catccccaac atccccggct cctgcaagga gaccttcaac ctcttctact 840
acgaggctga cagcgatgtg gcctcagcct cctccccctt ctggatggag aacccctacg 900
tgaaagtgga caccattgca cccgatgaga gcttctcgcg gctggatgcc ggccgtgtca 960
acaccaaggt gcgcagcttt gggccacttt ccaaggctgg cttctacctg gccttccagg 1020
accagggcgc ctgcatgtcg ctcatctccg tgcgcgcctt ctacaagaag tgtgcatcca 1080
ccaccgcagg cttcgcactc ttccccgaga ccctcactgg ggcggagccc acctcgctgg 1140
tcattgctcc tggcacctgc atccctaacg ccgtggaggt gtcggtgcca ctcaagctct 1200
actgcaacgg cgatggggag tggatggtgc ctgtgggtgc ctgcacctgt gccaccggcc 1260
atgagccagc tgccaaggag tcccagtgcc gcccctgtcc ccctgggagc tacaaggcga 1320
agcagggaga ggggccctgc ctcccatgtc cccccaacag ccgtaccacc tccccagccg 1380
ccagcatctg cacctgccac aataacttct accgtgcaga ctcggactct gcggacagtg 1440
cctgtaccac cgtgccatct ccaccccgag gtgtgatctc caatgtgaat gaaacctcac 1500
tgatcctcga gtggagtgag ccccgggacc tgggtggccg ggatgacctc ctgtacaatg 1560
tcatctgcaa gaagtgccat ggggctggag gggcctcagc ctgctcacgc tgtgatgaca 1620
acgtggagtt tgtgcctcgg cagctgggcc tgacggagcg ccgggtccac atcagccatc 1680
tgctggccca cacgcgctac acctttgagg tgcaggcggt caacggtgtc tcgggcaaga 1740
gccctctgcc gcctcgttat gcggccgtga atatcaccac aaaccaggct gccccgtctg 1800
aagtgcccac actacgcctg cacagcagct caggcagcag cctcacccta tcctgggcac 1860
ccccagagcg gcccaacgga gtcatcctgg actacgagat gaagtacttt gagaagagcg 1920
agggcatcgc ctccacagtg accagccaga tgaactccgt gcagctggac gggcttcggc 1980
ctgacgcccg ctatgtggtc caggtccgtg cccgcacagt agctggctat gggcagtaca 2040
gccgccctgc cgagtttgag accacaagtg agagaggctc tggggcccag cagctccagg 2100
agcagcttcc cctcatcgtg ggctccgcta cagctgggct tgtcttcgtg gtggctgtcg 2160
tggtcatcgc tatcgtctgc ctcaggaagc agcgacacgg ctctgattcg gagtacacgg 2220
agaagctgca gcagtacatt gctcctggaa tgaaggttta tattgaccct tttacctacg 2280
aggaccctaa tgaggctgtt cgggagtttg ccaaggagat cgacgtgtcc tgcgtcaaga 2340
tcgaggaggt gatcggagct ggggaatttg gggaagtgtg ccgtggtcga ctgaaacagc 2400
ctggccgccg agaggtgttt gtggccatca agacgctgaa ggtgggctac accgagaggc 2460
agcggcggga cttcctaagc gaggcctcca tcatgggtca gtttgatcac cccaatataa 2520
tccggctcga gggcgtggtc accaaaagtc ggccagttat gatcctcact gagttcatgg 2580
aaaactgcgc cctggactcc ttcctccggc tcaacgatgg gcagttcacg gtcatccagc 2640
tggtgggcat gttgcggggc attgctgccg gcatgaagta cctgtccgag atgaactatg 2700
tgcaccgcga cctggctgct cgcaacatcc ttgtcaacag caacctggtc tgcaaagtct 2760
cagactttgg cctctcccgc ttcctggagg atgacccctc cgatcctacc tacaccagtt 2820
ccctgggcgg gaagatcccc atccgctgga ctgccccaga ggccatagcc tatcggaagt 2880
tcacttctgc tagtgatgtc tggagctacg gaattgtcat gtgggaggtc atgagctatg 2940
gagagcgacc ctactgggac atgagcaacc aggatgtcat caatgccgtg gagcaggatt 3000
accggctgcc accacccatg gactgtccca cagcactgca ccagctcatg ctggactgct 3060
gggtgcggga ccggaacctc aggcccaaat tctcccagat tgtcaatacc ctggacaagc 3120
tcatccgcaa tgctgccagc ctcaaggtca ttgccagcgc tcagtctggc atgtcacagc 3180
ccctcctgga ccgcacggtc ccagattaca caaccttcac gacagttggt gattggctgg 3240
atgccatcaa gatggggcgg tacaaggaga gcttcgtcag tgcggggttt gcatcttttg 3300
acctggtggc ccagatgacg gcagaagacc tgctccgtat tggggtcacc ctggccggcc 3360
accagaagaa gatcctgagc agtatccagg acatgcggct gcagatgaac cagacgctgc 3420
ctgtgcaggt ctgacaccgg ctcccacggg gaccctgagg accgtgcagg gatgccaagc 3480
agccggctgg actttcggac tcttggactt ttggatgcct ggccttaggc tgtggcccag 3540
aagctggaag tttgggaaag gcccaagctg ggacttctcc aggcctgtgt tccctcccca 3600
ggaagtgcgc cccaaacctc ttcatattga agatggatta ggagaggggg tgatgacccc 3660
tccccaagcc cctcagggcc cagaccttcc tgctctccag caggggatcc ccacaacctc 3720
acacttgtct gttcttcagt gctggaggtc ctggcagggt caggctgggg taagccgggg 3780
ttccacaggg cccagccctg gcaggggtct ggccccccag gtaggcggag agcagtccct 3840
ccctcaggaa ctggaggagg ggactccagg aatggggaaa tgtgacacca ccatcctgaa 3900
gccagcttgc acctccagtt tgcacaggga tttgttctgg gggctgaggg ccctgtcccc 3960
acccccgccc ttggtgctgt cataaaaggg caggcagggg caggctgagg agttgccctt 4020
tgccccccag agactgactc tcagagccag agatgggatg tgtgagtgtg tgtgtgtgtg 4080
tgtgtgtgtg cgcgcgcgcg cgcgtgtgtg tgtgcacgca ctggcctgca cagagagcat 4140
gggtgagcgt gtaaaagctt ggccctgtgc cctacaatgg ggccagctgg gccgacagca 4200
gaataaaggc aataagatga aaaaaaaaaa aaaa                             4234

<210> 368
<211> 4369
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM004444
<309> 2004-11-16  

<400> 368
ttccagcgca gctcagcccc tgcccggccc ggcccgcccg gctccgcgcc gcagtctccc 60
tccctcccgc tccgtccccg ctcgggctcc caccatcccc gcccgcgagg agagcactcg 120
gcccggcggc gcgagcagag ccactccagg gaggggggga gaccgcgagc ggccggctca 180
gcccccgcca cccggggcgg gaccccgagg ccccggaggg accccaactc cagccacgtc 240
ttgctgcgcg cccgcccggc gcggccactg ccagcacgct ccgggcccgc cgcccgcgcg 300
cgcggcacag acgcggggcc acacttggcg ccgccgcccg gtgccccgca cgctcgcatg 360
ggcccgcgct gagggccccg acgaggagtc ccgcgcggag tatcggcgtc cacccgccca 420
gggagagtca gacctggggg ggcgagggcc ccccaaactc agttcggatc ctacccgagt 480
gaggcggcgc catggagctc cgggtgctgc tctgctgggc ttcgttggcc gcagctttgg 540
aagagaccct gctgaacaca aaattggaaa ctgctgatct gaagtgggtg acattccctc 600
aggtggacgg gcagtgggag gaactgagcg gcctggatga ggaacagcac agcgtgcgca 660
cctacgaagt gtgtgacgtg cagcgtgccc cgggccaggc ccactggctt cgcacaggtt 720
gggtcccacg gcggggcgcc gtccacgtgt acgccacgct gcgcttcacc atgctcgagt 780
gcctgtccct gcctcgggct gggcgctcct gcaaggagac cttcaccgtc ttctactatg 840
agagcgatgc ggacacggcc acggccctca cgccagcctg gatggagaac ccctacatca 900
aggtggacac ggtggccgcg gagcatctca cccggaagcg ccctggggcc gaggccaccg 960
ggaaggtgaa tgtcaagacg ctgcgtctgg gaccgctcag caaggctggc ttctacctgg 1020
ccttccagga ccagggtgcc tgcatggccc tgctatccct gcacctcttc tacaaaaagt 1080
gcgcccagct gactgtgaac ctgactcgat tcccggagac tgtgcctcgg gagctggttg 1140
tgcccgtggc cggtagctgc gtggtggatg ccgtccccgc ccctggcccc agccccagcc 1200
tctactgccg tgaggatggc cagtgggccg aacagccggt cacgggctgc agctgtgctc 1260
cggggttcga ggcagctgag gggaacacca agtgccgagc ctgtgcccag ggcaccttca 1320
agcccctgtc aggagaaggg tcctgccagc catgcccagc caatagccac tctaacacca 1380
ttggatcagc cgtctgccag tgccgcgtcg ggtacttccg ggcacgcaca gacccccggg 1440
gtgcaccctg caccacccct ccttcggctc cgcggagcgt ggtttcccgc ctgaacggct 1500
cctccctgca cctggaatgg agtgcccccc tggagtctgg tggccgagag gacctcacct 1560
acgccctccg ctgccgggag tgccgacccg gaggctcctg tgcgccctgc gggggagacc 1620
tgacttttga ccccggcccc cgggacctgg tggagccctg ggtggtggtt cgagggctac 1680
gtcctgactt cacctatacc tttgaggtca ctgcattgaa cggggtatcc tccttagcca 1740
cggggcccgt cccatttgag cctgtcaatg tcaccactga ccgagaggta cctcctgcag 1800
tgtctgacat ccgggtgacg cggtcctcac ccagcagctt gagcctggcc tgggctgttc 1860
cccgggcacc cagtggggct gtgctggact acgaggtcaa ataccatgag aagggcgccg 1920
agggtcccag cagcgtgcgg ttcctgaaga cgtcagaaaa ccgggcagag ctgcgggggc 1980
tgaagcgggg agccagctac ctggtgcagg tacgggcgcg ctctgaggcc ggctacgggc 2040
ccttcggcca ggaacatcac agccagaccc aactggatga gagcgagggc tggcgggagc 2100
agctggccct gattgcgggc acggcagtcg tgggtgtggt cctggtcctg gtggtcattg 2160
tggtcgcagt tctctgcctc aggaagcaga gcaatgggag agaagcagaa tattcggaca 2220
aacacggaca gtatctcatc ggacatggta ctaaggtcta catcgacccc ttcacttatg 2280
aagaccctaa tgaggctgtg agggaatttg caaaagagat cgatgtctcc tacgtcaaga 2340
ttgaagaggt gattggtgca ggtgagtttg gcgaggtgtg ccgggggcgg ctcaaggccc 2400
cagggaagaa ggagagctgt gtggcaatca agaccctgaa gggtggctac acggagcggc 2460
agcggcgtga gtttctgagc gaggcctcca tcatgggcca gttcgagcac cccaatatca 2520
tccgcctgga gggcgtggtc accaacagca tgcccgtcat gattctcaca gagttcatgg 2580
agaacggcgc cctggactcc ttcctgcggc taaacgacgg acagttcaca gtcatccagc 2640
tcgtgggcat gctgcggggc atcgcctcgg gcatgcggta ccttgccgag atgagctacg 2700
tccaccgaga cctggctgct cgcaacatcc tagtcaacag caacctcgtc tgcaaagtgt 2760
ctgactttgg cctttcccga ttcctggagg agaactcttc cgatcccacc tacacgagct 2820
ccctgggagg aaagattccc atccgatgga ctgccccgga ggccattgcc ttccggaagt 2880
tcacttccgc cagtgatgcc tggagttacg ggattgtgat gtgggaggtg atgtcatttg 2940
gggagaggcc gtactgggac atgagcaatc aggacgtgat caatgccatt gaacaggact 3000
accggctgcc cccgccccca gactgtccca cctccctcca ccagctcatg ctggactgtt 3060
ggcagaaaga ccggaatgcc cggccccgct tcccccaggt ggtcagcgcc ctggacaaga 3120
tgatccggaa ccccgccagc ctcaaaatcg tggcccggga gaatggcggg gcctcacacc 3180
ctctcctgga ccagcggcag cctcactact cagcttttgg ctctgtgggc gagtggcttc 3240
gggccatcaa aatgggaaga tacgaagaaa gtttcgcagc cgctggcttt ggctccttcg 3300
agctggtcag ccagatctct gctgaggacc tgctccgaat cggagtcact ctggcgggac 3360
accagaagaa aatcttggcc agtgtccagc acatgaagtc ccaggccaag ccgggaaccc 3420
cgggtgggac aggaggaccg gccccgcagt actgacctgc aggaactccc caccccaggg 3480
acaccgcctc cccattttcc ggggcagagt ggggactcac agaggccccc agccctgtgc 3540
cccgctggat tgcactttga gcccgtgggg tgaggagttg gcaatttgga gagacaggat 3600
ttgggggttc tgccataata ggaggggaaa atcacccccc agccacctcg gggaactcca 3660
gaccaagggt gagggcgcct ttccctcagg actgggtgtg accagaggaa aaggaagtgc 3720
ccaacatctc ccagcctccc caggtgcccc cctcaccttg atgggtgcgt tcccgcagac 3780
caaagagagt gtgactccct tgccagctcc agagtggggg ggctgtccca gggggcaaga 3840
aggggtgtca gggcccagtg acaaaatcat tggggtttgt agtcccaact tgctgctgtc 3900
accaccaaac tcaatcattt ttttcccttg taaatgcccc tcccccagct gctgccttca 3960
tattgaaggt ttttgagttt tgtttttggt cttaattttt ctccccgttc cctttttgtt 4020
tcttcgtttt gtttttctac cgtccttgtc ataactttgt gttggaggga acctgtttca 4080
ctatggcctc ctttgcccaa gttgaaacag gggcccatca tcatgtctgt ttccagaaca 4140
gtgccttggt catcccacat ccccggaccc cgcctgggac ccccaagctg tgtcctatga 4200
aggggtgtgg ggtgaggtag tgaaaagggc ggtagttggt ggtggaaccc agaaacggac 4260
gccggtgctt ggaggggttc ttaaattata tttaaaaaag taactttttg tataaataaa 4320
agaaaatggg acgtgtccca gctccagggg taaaaaaaaa aaaaaaaaa             4369

<210> 369
<211> 4059
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM004445
<309> 2004-11-29  

<400> 369
ggggcgggcc gggccggctt gggaggggac gcggaggggg cgggccgggc tgcgttcgct 60
ccagccgcgg ctctacagca gcgggcggcg ggacccggga cccagcttgg cgacggcgat 120
ctcgacgcgg gcccccagga tctcccggcg ccccacctct ggagcagccc ctgccgccag 180
cgtcaggtcc accccggaat cccagggact ctcggcgccg aacggacccg ggccgggtgc 240
aacggggtcc ccggactgga gaagacgcgg gtggcaccgt gcgagctcca ggagccccgg 300
gtccactgcg aggcctcggg gggcgcagac ctgcagagac tgcggccaac gggaagaaat 360
aaagggatta tagtccaccc aattcacaga cttctgagac tcagacacga ggagagatag 420
agaaccgcca atctctagat caacaagcaa aggaggtgcc aagcctgttt gtcttcattg 480
tgacactgga gtctagatgc tgggaagtcc aagatcaggg tgccggcatg gtcagttcct 540
ggcgaagcct ctcttctagg tttcagactg ccctcttctt tgttgtgtcc tcgaatggca 600
gaaaaagggg tggctgttgg aggaagggag gagagtaaat gaagagaaag aactggaata 660
accccttgca gaaaaaaaaa aaaagggaag caagcttagc tgtacaccct gagtcttgca 720
aaagctgcag ccccacccag gagcagggtg gtggctgggg cgatggtgga cgccctgaag 780
atgtcccatg gctactgaag gggctgccca gttagggaac agagtggcgg gcatggtgtg 840
tagcctatgg gtgctgctcc tggtgtcttc agttctggct ctggaagagg tattgctgga 900
caccaccgga gagacatctg agattggctg gctcacctac ccaccagggg ggtgggacga 960
ggtgagtgtt ctggacgacc agcgacgcct gactcggacc tttgaggcat gtcatgtggc 1020
aggggcccct ccaggcaccg ggcaggacaa ttggttgcag acacactttg tggagcggcg 1080
cggggcccag agggcgcaca ttcgactcca cttctctgtg cgggcatgct ccagcctggg 1140
tgtgagcggc ggcacctgcc gggagacctt caccctttac taccgtcagg ctgaggagcc 1200
cgacagccct gacagcgttt cctcctggca cctcaaacgc tggaccaagg tggacacaat 1260
tgcagcagac gagagctttc cctcctcctc ctcctcctcc tcctcttctt cctctgcagc 1320
gtgggctgtg ggaccccacg gggctgggca gcgggctgga ctgcaactga acgtcaaaga 1380
gcggagcttt gggcctctca cccaacgcgg cttctacgtg gccttccagg acacgggggc 1440
ctgcctggcc ctggtcgctg tcaggctctt ctcctacacc tgccctgccg tgctccgatc 1500
ctttgcttcc tttccagaga cgcaggccag tggggctggg ggggcctccc tggtggcagc 1560
tgtgggcacc tgtgtggctc atgcagagcc agaggaggat ggagtagggg gccaggcagg 1620
aggcagcccc cccaggctgc actgcaacgg ggagggcaag tggatggtag ctgtcggggg 1680
ctgccgctgc cagcctggat accaaccagc acgaggagac aaggcctgcc aagcctgccc 1740
acgggggctc tataagtctt ctgctgggaa tgctccctgc tcaccatgcc ctgcccgcag 1800
tcacgctccc aacccagcag cccccgtttg cccctgcctg gagggcttct accgggccag 1860
ttccgaccca ccagaggccc cctgcactgg tcctccatcg gctccccagg agctttggtt 1920
tgaggtgcaa ggctcagcac tcatgctaca ctggcgcctg cctcgggagc tggggggtcg 1980
aggggacctg ctcttcaatg tcgtgtgcaa ggagtgtgaa ggccgccagg aacctgccag 2040
cggtggtggg ggcacttgtc accgctgcag ggatgaggtc cacttcgacc ctcgccagag 2100
aggcctgact gagagccgag tgttagtggg gggactccgg gcacacgtac cctacatctt 2160
agaggtgcag gctgttaatg gggtgtctga gctcagccct gaccctcctc aggctgcagc 2220
catcaatgtc agcaccagcc atgaagtgcc ctctgctgtc cctgtggtgc accaggtgag 2280
ccgggcatcc aacagcatca cggtgtcctg gccgcagccc gaccagacca atgggaacat 2340
cctggactat cagctccgct actatgacca ggcagaagac gaatcccact ccttcaccct 2400
gaccagcgag accaacactg ccaccgtgac acagctgagc cctggccaca tctatggttt 2460
ccaggtgcgg gcccggactg ctgccggcca cggcccctac gggggcaaag tctatttcca 2520
gacacttcct caaggggagc tgtcttccca gcttccggaa agactctcct tggtgatcgg 2580
ctccatcctg ggggctttgg ccttcctcct gctggcagcc atcaccgtgc tggcggtcgt 2640
cttccagcgg aagcggcgtg ggactggcta cacggagcag ctgcagcaat acagcagccc 2700
aggactcggg gtgaagtatt acatcgaccc ctccacctac gaggacccct gtcaggccat 2760
ccgagaactt gcccgggaag tcgatcctgc ttatatcaag attgaggagg tcattgggac 2820
aggctctttt ggagaagtgc gccagggccg cctgcagcca cggggacgga gggagcagac 2880
tgtggccatc caggccctgt gggccggggg cgccgaaagc ctgcagatga ccttcctggg 2940
ccgggccgca gtgctgggtc agttccagca ccccaacatc ctgcggctgg agggcgtggt 3000
caccaagagc cgacccctca tggtgctgac ggagttcatg gagcttggcc ccctggacag 3060
cttcctcagg cagcgggagg gccagttcag cagcctgcag ctggtggcca tgcagcgggg 3120
agtggctgct gccatgcagt acctgtccag ctttgccttc gtccatcgct cgctgtctgc 3180
ccacagcgtg ctggtgaata gccacttggt gtgcaaggtg gcccgtcttg gccacagtcc 3240
tcagggccca agttgtttgc ttcgctgggc agccccagag gtcattgcac atggaaagca 3300
tacaacatcc agtgatgtct ggagctttgg gatactcatg tgggaagtga tgagttatgg 3360
agaacggcct tactgggaca tgagtgagca ggaggtacta aatgcaatag agcaggagtt 3420
ccggctgccc ccgcctccag gctgtcctcc tggattacat ctacttatgt tggacacttg 3480
gcagaaggac cgtgcccggc ggcctcattt tgaccagctg gtggctgcat ttgacaagat 3540
gatccgcaag ccagataccc tgcaggctgg cggggaccca ggggaaaggc cttcccaggc 3600
ccttctgacc cctgtggccc tggactttcc ttgtctggac tcaccccagg cctggctttc 3660
agccattgga ctggagtgct accaggacaa cttctccaag tttggcctct gtaccttcag 3720
tgatgtggct cagctcagcc tagaagacct gcctgccctg ggcatcaccc tggctggcca 3780
ccagaagaag ctgctgcacc acatccagct ccttcagcaa cacctgaggc agcagggctc 3840
agtggaggtc tgagaatgac gatacccgtg actcagccct ggacactggt ccgagaaggg 3900
acatgtggga cgtgagccgg gctccaacag cctctgtgag agatgcccca caccaaaccc 3960
aaccctcccg atggctgcat tccctggtcc tccgcctctc caccagcccc ctcctcatta 4020
aagggaaaga agggaatttg caaaaaaaaa aaaaaaaaa                        4059

<210> 370
<211> 5616
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM005228
<309> 2005-01-26  

<400> 370
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg 60
gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac 120
aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc 180
gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga 240
gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc 300
tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc 360
acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt 420
gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc 480
ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga 540
attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc 600
ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga 660
aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac 720
gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg 780
gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc 840
tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag 900
tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca 960
ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc 1020
acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat 1080
gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat 1140
tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg 1200
gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac 1260
ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac 1320
ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt 1380
gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta 1440
aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat 1500
gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt 1560
gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat 1620
ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa 1680
aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc 1740
tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg 1800
gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag 1860
tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc 1920
cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac 1980
tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga 2040
gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac 2100
ctgtgccatc caaactgcac ctacggatgc actgggccag gtcttgaagg ctgtccaacg 2160
aatgggccta agatcccgtc catcgccact gggatggtgg gggccctcct cttgctgctg 2220
gtggtggccc tggggatcgg cctcttcatg cgaaggcgcc acatcgttcg gaagcgcacg 2280
ctgcggaggc tgctgcagga gagggagctt gtggagcctc ttacacccag tggagaagct 2340
cccaaccaag ctctcttgag gatcttgaag gaaactgaat tcaaaaagat caaagtgctg 2400
ggctccggtg cgttcggcac ggtgtataag ggactctgga tcccagaagg tgagaaagtt 2460
aaaattcccg tcgctatcaa ggaattaaga gaagcaacat ctccgaaagc caacaaggaa 2520
atcctcgatg aagcctacgt gatggccagc gtggacaacc cccacgtgtg ccgcctgctg 2580
ggcatctgcc tcacctccac cgtgcagctc atcacgcagc tcatgccctt cggctgcctc 2640
ctggactatg tccgggaaca caaagacaat attggctccc agtacctgct caactggtgt 2700
gtgcagatcg caaagggcat gaactacttg gaggaccgtc gcttggtgca ccgcgacctg 2760
gcagccagga acgtactggt gaaaacaccg cagcatgtca agatcacaga ttttgggctg 2820
gccaaactgc tgggtgcgga agagaaagaa taccatgcag aaggaggcaa agtgcctatc 2880
aagtggatgg cattggaatc aattttacac agaatctata cccaccagag tgatgtctgg 2940
agctacgggg tgaccgtttg ggagttgatg acctttggat ccaagccata tgacggaatc 3000
cctgccagcg agatctcctc catcctggag aaaggagaac gcctccctca gccacccata 3060
tgtaccatcg atgtctacat gatcatggtc aagtgctgga tgatagacgc agatagtcgc 3120
ccaaagttcc gtgagttgat catcgaattc tccaaaatgg cccgagaccc ccagcgctac 3180
cttgtcattc agggggatga aagaatgcat ttgccaagtc ctacagactc caacttctac 3240
cgtgccctga tggatgaaga agacatggac gacgtggtgg atgccgacga gtacctcatc 3300
ccacagcagg gcttcttcag cagcccctcc acgtcacgga ctcccctcct gagctctctg 3360
agtgcaacca gcaacaattc caccgtggct tgcattgata gaaatgggct gcaaagctgt 3420
cccatcaagg aagacagctt cttgcagcga tacagctcag accccacagg cgccttgact 3480
gaggacagca tagacgacac cttcctccca gtgcctgaat acataaacca gtccgttccc 3540
aaaaggcccg ctggctctgt gcagaatcct gtctatcaca atcagcctct gaaccccgcg 3600
cccagcagag acccacacta ccaggacccc cacagcactg cagtgggcaa ccccgagtat 3660
ctcaacactg tccagcccac ctgtgtcaac agcacattcg acagccctgc ccactgggcc 3720
cagaaaggca gccaccaaat tagcctggac aaccctgact accagcagga cttctttccc 3780
aaggaagcca agccaaatgg catctttaag ggctccacag ctgaaaatgc agaataccta 3840
agggtcgcgc cacaaagcag tgaatttatt ggagcatgac cacggaggat agtatgagcc 3900
ctaaaaatcc agactctttc gatacccagg accaagccac agcaggtcct ccatcccaac 3960
agccatgccc gcattagctc ttagacccac agactggttt tgcaacgttt acaccgacta 4020
gccaggaagt acttccacct cgggcacatt ttgggaagtt gcattccttt gtcttcaaac 4080
tgtgaagcat ttacagaaac gcatccagca agaatattgt ccctttgagc agaaatttat 4140
ctttcaaaga ggtatatttg aaaaaaaaaa aaagtatatg tgaggatttt tattgattgg 4200
ggatcttgga gtttttcatt gtcgctattg atttttactt caatgggctc ttccaacaag 4260
gaagaagctt gctggtagca cttgctaccc tgagttcatc caggcccaac tgtgagcaag 4320
gagcacaagc cacaagtctt ccagaggatg cttgattcca gtggttctgc ttcaaggctt 4380
ccactgcaaa acactaaaga tccaagaagg ccttcatggc cccagcaggc cggatcggta 4440
ctgtatcaag tcatggcagg tacagtagga taagccactc tgtcccttcc tgggcaaaga 4500
agaaacggag gggatggaat tcttccttag acttactttt gtaaaaatgt ccccacggta 4560
cttactcccc actgatggac cagtggtttc cagtcatgag cgttagactg acttgtttgt 4620
cttccattcc attgttttga aactcagtat gctgcccctg tcttgctgtc atgaaatcag 4680
caagagagga tgacacatca aataataact cggattccag cccacattgg attcatcagc 4740
atttggacca atagcccaca gctgagaatg tggaatacct aaggatagca ccgcttttgt 4800
tctcgcaaaa acgtatctcc taatttgagg ctcagatgaa atgcatcagg tcctttgggg 4860
catagatcag aagactacaa aaatgaagct gctctgaaat ctcctttagc catcacccca 4920
accccccaaa attagtttgt gttacttatg gaagatagtt ttctcctttt acttcacttc 4980
aaaagctttt tactcaaaga gtatatgttc cctccaggtc agctgccccc aaaccccctc 5040
cttacgcttt gtcacacaaa aagtgtctct gccttgagtc atctattcaa gcacttacag 5100
ctctggccac aacagggcat tttacaggtg cgaatgacag tagcattatg agtagtgtgg 5160
aattcaggta gtaaatatga aactagggtt tgaaattgat aatgctttca caacatttgc 5220
agatgtttta gaaggaaaaa agttccttcc taaaataatt tctctacaat tggaagattg 5280
gaagattcag ctagttagga gcccaccttt tttcctaatc tgtgtgtgcc ctgtaacctg 5340
actggttaac agcagtcctt tgtaaacagt gttttaaact ctcctagtca atatccaccc 5400
catccaattt atcaaggaag aaatggttca gaaaatattt tcagcctaca gttatgttca 5460
gtcacacaca catacaaaat gttccttttg cttttaaagt aatttttgac tcccagatca 5520
gtcagagccc ctacagcatt gttaagaaag tatttgattt ttgtctcaat gaaaataaaa 5580
ctatattcat ttccactcta aaaaaaaaaa aaaaaa                           5616

<210> 371
<211> 4624
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM004448
<309> 2004-12-20  

<400> 371
ggaggaggtg gaggaggagg gctgcttgag gaagtataag aatgaagttg tgaagctgag 60
attcccctcc attgggaccg gagaaaccag gggagccccc cgggcagccg cgcgcccctt 120
cccacggggc cctttactgc gccgcgcgcc cggcccccac ccctcgcagc accccgcgcc 180
ccgcgccctc ccagccgggt ccagccggag ccatggggcc ggagccgcag tgagcaccat 240
ggagctggcg gccttgtgcc gctgggggct cctcctcgcc ctcttgcccc ccggagccgc 300
gagcacccaa gtgtgcaccg gcacagacat gaagctgcgg ctccctgcca gtcccgagac 360
ccacctggac atgctccgcc acctctacca gggctgccag gtggtgcagg gaaacctgga 420
actcacctac ctgcccacca atgccagcct gtccttcctg caggatatcc aggaggtgca 480
gggctacgtg ctcatcgctc acaaccaagt gaggcaggtc ccactgcaga ggctgcggat 540
tgtgcgaggc acccagctct ttgaggacaa ctatgccctg gccgtgctag acaatggaga 600
cccgctgaac aataccaccc ctgtcacagg ggcctcccca ggaggcctgc gggagctgca 660
gcttcgaagc ctcacagaga tcttgaaagg aggggtcttg atccagcgga acccccagct 720
ctgctaccag gacacgattt tgtggaagga catcttccac aagaacaacc agctggctct 780
cacactgata gacaccaacc gctctcgggc ctgccacccc tgttctccga tgtgtaaggg 840
ctcccgctgc tggggagaga gttctgagga ttgtcagagc ctgacgcgca ctgtctgtgc 900
cggtggctgt gcccgctgca aggggccact gcccactgac tgctgccatg agcagtgtgc 960
tgccggctgc acgggcccca agcactctga ctgcctggcc tgcctccact tcaaccacag 1020
tggcatctgt gagctgcact gcccagccct ggtcacctac aacacagaca cgtttgagtc 1080
catgcccaat cccgagggcc ggtatacatt cggcgccagc tgtgtgactg cctgtcccta 1140
caactacctt tctacggacg tgggatcctg caccctcgtc tgccccctgc acaaccaaga 1200
ggtgacagca gaggatggaa cacagcggtg tgagaagtgc agcaagccct gtgcccgagt 1260
gtgctatggt ctgggcatgg agcacttgcg agaggtgagg gcagttacca gtgccaatat 1320
ccaggagttt gctggctgca agaagatctt tgggagcctg gcatttctgc cggagagctt 1380
tgatggggac ccagcctcca acactgcccc gctccagcca gagcagctcc aagtgtttga 1440
gactctggaa gagatcacag gttacctata catctcagca tggccggaca gcctgcctga 1500
cctcagcgtc ttccagaacc tgcaagtaat ccggggacga attctgcaca atggcgccta 1560
ctcgctgacc ctgcaagggc tgggcatcag ctggctgggg ctgcgctcac tgagggaact 1620
gggcagtgga ctggccctca tccaccataa cacccacctc tgcttcgtgc acacggtgcc 1680
ctgggaccag ctctttcgga acccgcacca agctctgctc cacactgcca accggccaga 1740
ggacgagtgt gtgggcgagg gcctggcctg ccaccagctg tgcgcccgag ggcactgctg 1800
gggtccaggg cccacccagt gtgtcaactg cagccagttc cttcggggcc aggagtgcgt 1860
ggaggaatgc cgagtactgc aggggctccc cagggagtat gtgaatgcca ggcactgttt 1920
gccgtgccac cctgagtgtc agccccagaa tggctcagtg acctgttttg gaccggaggc 1980
tgaccagtgt gtggcctgtg cccactataa ggaccctccc ttctgcgtgg cccgctgccc 2040
cagcggtgtg aaacctgacc tctcctacat gcccatctgg aagtttccag atgaggaggg 2100
cgcatgccag ccttgcccca tcaactgcac ccactcctgt gtggacctgg atgacaaggg 2160
ctgccccgcc gagcagagag ccagccctct gacgtccatc atctctgcgg tggttggcat 2220
tctgctggtc gtggtcttgg gggtggtctt tgggatcctc atcaagcgac ggcagcagaa 2280
gatccggaag tacacgatgc ggagactgct gcaggaaacg gagctggtgg agccgctgac 2340
acctagcgga gcgatgccca accaggcgca gatgcggatc ctgaaagaga cggagctgag 2400
gaaggtgaag gtgcttggat ctggcgcttt tggcacagtc tacaagggca tctggatccc 2460
tgatggggag aatgtgaaaa ttccagtggc catcaaagtg ttgagggaaa acacatcccc 2520
caaagccaac aaagaaatct tagacgaagc atacgtgatg gctggtgtgg gctccccata 2580
tgtctcccgc cttctgggca tctgcctgac atccacggtg cagctggtga cacagcttat 2640
gccctatggc tgcctcttag accatgtccg ggaaaaccgc ggacgcctgg gctcccagga 2700
cctgctgaac tggtgtatgc agattgccaa ggggatgagc tacctggagg atgtgcggct 2760
cgtacacagg gacttggccg ctcggaacgt gctggtcaag agtcccaacc atgtcaaaat 2820
tacagacttc gggctggctc ggctgctgga cattgacgag acagagtacc atgcagatgg 2880
gggcaaggtg cccatcaagt ggatggcgct ggagtccatt ctccgccggc ggttcaccca 2940
ccagagtgat gtgtggagtt atggtgtgac tgtgtgggag ctgatgactt ttggggccaa 3000
accttacgat gggatcccag cccgggagat ccctgacctg ctggaaaagg gggagcggct 3060
gccccagccc cccatctgca ccattgatgt ctacatgatc atggtcaaat gttggatgat 3120
tgactctgaa tgtcggccaa gattccggga gttggtgtct gaattctccc gcatggccag 3180
ggacccccag cgctttgtgg tcatccagaa tgaggacttg ggcccagcca gtcccttgga 3240
cagcaccttc taccgctcac tgctggagga cgatgacatg ggggacctgg tggatgctga 3300
ggagtatctg gtaccccagc agggcttctt ctgtccagac cctgccccgg gcgctggggg 3360
catggtccac cacaggcacc gcagctcatc taccaggagt ggcggtgggg acctgacact 3420
agggctggag ccctctgaag aggaggcccc caggtctcca ctggcaccct ccgaaggggc 3480
tggctccgat gtatttgatg gtgacctggg aatgggggca gccaaggggc tgcaaagcct 3540
ccccacacat gaccccagcc ctctacagcg gtacagtgag gaccccacag tacccctgcc 3600
ctctgagact gatggctacg ttgcccccct gacctgcagc ccccagcctg aatatgtgaa 3660
ccagccagat gttcggcccc agcccccttc gccccgagag ggccctctgc ctgctgcccg 3720
acctgctggt gccactctgg aaaggcccaa gactctctcc ccagggaaga atggggtcgt 3780
caaagacgtt tttgcctttg ggggtgccgt ggagaacccc gagtacttga caccccaggg 3840
aggagctgcc cctcagcccc accctcctcc tgccttcagc ccagccttcg acaacctcta 3900
ttactgggac caggacccac cagagcgggg ggctccaccc agcaccttca aagggacacc 3960
tacggcagag aacccagagt acctgggtct ggacgtgcca gtgtgaacca gaaggccaag 4020
tccgcagaag ccctgatgtg tcctcaggga gcagggaagg cctgacttct gctggcatca 4080
agaggtggga gggccctccg accacttcca ggggaacctg ccatgccagg aacctgtcct 4140
aaggaacctt ccttcctgct tgagttccca gatggctgga aggggtccag cctcgttgga 4200
agaggaacag cactggggag tctttgtgga ttctgaggcc ctgcccaatg agactctagg 4260
gtccagtgga tgccacagcc cagcttggcc ctttccttcc agatcctggg tactgaaagc 4320
cttagggaag ctggcctgag aggggaagcg gccctaaggg agtgtctaag aacaaaagcg 4380
acccattcag agactgtccc tgaaacctag tactgccccc catgaggaag gaacagcaat 4440
ggtgtcagta tccaggcttt gtacagagtg cttttctgtt tagtttttac tttttttgtt 4500
ttgttttttt aaagatgaaa taaagaccca gggggagaat gggtgttgta tggggaggca 4560
agtgtggggg gtccttctcc acacccactt tgtccatttg caaatatatt ttggaaaaca 4620
gcta                                                              4624

<210> 372
<211> 5511
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM001982
<309> 2004-12-20  

<400> 372
acacacacac acccctcccc tgccatccct ccccggactc cggctccggc tccgattgca 60
atttgcaacc tccgctgccg tcgccgcagc agccaccaat tcgccagcgg ttcaggtggc 120
tcttgcctcg atgtcctagc ctaggggccc ccgggccgga cttggctggg ctcccttcac 180
cctctgcgga gtcatgaggg cgaacgacgc tctgcaggtg ctgggcttgc ttttcagcct 240
ggcccggggc tccgaggtgg gcaactctca ggcagtgtgt cctgggactc tgaatggcct 300
gagtgtgacc ggcgatgctg agaaccaata ccagacactg tacaagctct acgagaggtg 360
tgaggtggtg atggggaacc ttgagattgt gctcacggga cacaatgccg acctctcctt 420
cctgcagtgg attcgagaag tgacaggcta tgtcctcgtg gccatgaatg aattctctac 480
tctaccattg cccaacctcc gcgtggtgcg agggacccag gtctacgatg ggaagtttgc 540
catcttcgtc atgttgaact ataacaccaa ctccagccac gctctgcgcc agctccgctt 600
gactcagctc accgagattc tgtcaggggg tgtttatatt gagaagaacg ataagctttg 660
tcacatggac acaattgact ggagggacat cgtgagggac cgagatgctg agatagtggt 720
gaaggacaat ggcagaagct gtcccccctg tcatgaggtt tgcaaggggc gatgctgggg 780
tcctggatca gaagactgcc agacattgac caagaccatc tgtgctcctc agtgtaatgg 840
tcactgcttt gggcccaacc ccaaccagtg ctgccatgat gagtgtgccg ggggctgctc 900
aggccctcag gacacagact gctttgcctg ccggcacttc aatgacagtg gagcctgtgt 960
acctcgctgt ccacagcctc ttgtctacaa caagctaact ttccagctgg aacccaatcc 1020
ccacaccaag tatcagtatg gaggagtttg tgtagccagc tgtccccata actttgtggt 1080
ggatcaaaca tcctgtgtca gggcctgtcc tcctgacaag atggaagtag ataaaaatgg 1140
gctcaagatg tgtgagcctt gtgggggact atgtcccaaa gcctgtgagg gaacaggctc 1200
tgggagccgc ttccagactg tggactcgag caacattgat ggatttgtga actgcaccaa 1260
gatcctgggc aacctggact ttctgatcac cggcctcaat ggagacccct ggcacaagat 1320
ccctgccctg gacccagaga agctcaatgt cttccggaca gtacgggaga tcacaggtta 1380
cctgaacatc cagtcctggc cgccccacat gcacaacttc agtgtttttt ccaatttgac 1440
aaccattgga ggcagaagcc tctacaaccg gggcttctca ttgttgatca tgaagaactt 1500
gaatgtcaca tctctgggct tccgatccct gaaggaaatt agtgctgggc gtatctatat 1560
aagtgccaat aggcagctct gctaccacca ctctttgaac tggaccaagg tgcttcgggg 1620
gcctacggaa gagcgactag acatcaagca taatcggccg cgcagagact gcgtggcaga 1680
gggcaaagtg tgtgacccac tgtgctcctc tgggggatgc tggggcccag gccctggtca 1740
gtgcttgtcc tgtcgaaatt atagccgagg aggtgtctgt gtgacccact gcaactttct 1800
gaatggggag cctcgagaat ttgcccatga ggccgaatgc ttctcctgcc acccggaatg 1860
ccaacccatg gagggcactg ccacatgcaa tggctcgggc tctgatactt gtgctcaatg 1920
tgcccatttt cgagatgggc cccactgtgt gagcagctgc ccccatggag tcctaggtgc 1980
caagggccca atctacaagt acccagatgt tcagaatgaa tgtcggccct gccatgagaa 2040
ctgcacccag gggtgtaaag gaccagagct tcaagactgt ttaggacaaa cactggtgct 2100
gatcggcaaa acccatctga caatggcttt gacagtgata gcaggattgg tagtgatttt 2160
catgatgctg ggcggcactt ttctctactg gcgtgggcgc cggattcaga ataaaagggc 2220
tatgaggcga tacttggaac ggggtgagag catagagcct ctggacccca gtgagaaggc 2280
taacaaagtc ttggccagaa tcttcaaaga gacagagcta aggaagctta aagtgcttgg 2340
ctcgggtgtc tttggaactg tgcacaaagg agtgtggatc cctgagggtg aatcaatcaa 2400
gattccagtc tgcattaaag tcattgagga caagagtgga cggcagagtt ttcaagctgt 2460
gacagatcat atgctggcca ttggcagcct ggaccatgcc cacattgtaa ggctgctggg 2520
actatgccca gggtcatctc tgcagcttgt cactcaatat ttgcctctgg gttctctgct 2580
ggatcatgtg agacaacacc ggggggcact ggggccacag ctgctgctca actggggagt 2640
acaaattgcc aagggaatgt actaccttga ggaacatggt atggtgcata gaaacctggc 2700
tgcccgaaac gtgctactca agtcacccag tcaggttcag gtggcagatt ttggtgtggc 2760
tgacctgctg cctcctgatg ataagcagct gctatacagt gaggccaaga ctccaattaa 2820
gtggatggcc cttgagagta tccactttgg gaaatacaca caccagagtg atgtctggag 2880
ctatggtgtg acagtttggg agttgatgac cttcggggca gagccctatg cagggctacg 2940
attggctgaa gtaccagacc tgctagagaa gggggagcgg ttggcacagc cccagatctg 3000
cacaattgat gtctacatgg tgatggtcaa gtgttggatg attgatgaga acattcgccc 3060
aacctttaaa gaactagcca atgagttcac caggatggcc cgagacccac cacggtatct 3120
ggtcataaag agagagagtg ggcctggaat agcccctggg ccagagcccc atggtctgac 3180
aaacaagaag ctagaggaag tagagctgga gccagaacta gacctagacc tagacttgga 3240
agcagaggag gacaacctgg caaccaccac actgggctcc gccctcagcc taccagttgg 3300
aacacttaat cggccacgtg ggagccagag ccttttaagt ccatcatctg gatacatgcc 3360
catgaaccag ggtaatcttg gggagtcttg ccaggagtct gcagtttctg ggagcagtga 3420
acggtgcccc cgtccagtct ctctacaccc aatgccacgg ggatgcctgg catcagagtc 3480
atcagagggg catgtaacag gctctgaggc tgagctccag gagaaagtgt caatgtgtag 3540
gagccggagc aggagccgga gcccacggcc acgcggagat agcgcctacc attcccagcg 3600
ccacagtctg ctgactcctg ttaccccact ctccccaccc gggttagagg aagaggatgt 3660
caacggttat gtcatgccag atacacacct caaaggtact ccctcctccc gggaaggcac 3720
cctttcttca gtgggtctca gttctgtcct gggtactgaa gaagaagatg aagatgagga 3780
gtatgaatac atgaaccgga ggagaaggca cagtccacct catcccccta ggccaagttc 3840
ccttgaggag ctgggttatg agtacatgga tgtggggtca gacctcagtg cctctctggg 3900
cagcacacag agttgcccac tccaccctgt acccatcatg cccactgcag gcacaactcc 3960
agatgaagac tatgaatata tgaatcggca acgagatgga ggtggtcctg ggggtgatta 4020
tgcagccatg ggggcctgcc cagcatctga gcaagggtat gaagagatga gagcttttca 4080
ggggcctgga catcaggccc cccatgtcca ttatgcccgc ctaaaaactc tacgtagctt 4140
agaggctaca gactctgcct ttgataaccc tgattactgg catagcaggc ttttccccaa 4200
ggctaatgcc cagagaacgt aactcctgct ccctgtggca ctcagggagc atttaatggc 4260
agctagtgcc tttagagggt accgtcttct ccctattccc tctctctccc aggtcccagc 4320
cccttttccc cagtcccaga caattccatt caatctttgg aggcttttaa acattttgac 4380
acaaaattct tatggtatgt agccagctgt gcactttctt ctctttccca accccaggaa 4440
aggttttcct tattttgtgt gctttcccag tcccattcct cagcttcttc acaggcactc 4500
ctggagatat gaaggattac tctccatatc ccttcctctc aggctcttga ctacttggaa 4560
ctaggctctt atgtgtgcct ttgtttccca tcagactgtc aagaagagga aagggaggaa 4620
acctagcaga ggaaagtgta attttggttt atgactctta accccctaga aagacagaag 4680
cttaaaatct gtgaagaaag aggttaggag tagatattga ttactatcat aattcagcac 4740
ttaactatga gccaggcatc atactaaact tcacctacat tatctcactt agtcctttat 4800
catccttaaa acaattctgt gacatacata ttatctcatt ttacacaaag ggaagtcggg 4860
catggtggct catgcctgta atctcagcac tttgggaggc tgaggcagaa ggattacctg 4920
aggcaaggag tttgagacca gcttagccaa catagtaaga cccccatctc tttaaaaaaa 4980
aaaaaaaaaa aaaaaaaaaa actttagaac tgggtgcagt ggctcatgcc tgtaatccca 5040
gccagcactt tgggaggctg agatgggaag atcacttgag cccagaatta gagataagcc 5100
tatggaaaca tagcaagaca ctgtctctac aggggaaaaa aaaaaaagaa actgagcctt 5160
aaagagatga aataaattaa gcagtagatc caggatgcaa aatcctccca attcctgtgc 5220
atgtgctctt attgtaaggt gccaagaaaa actgatttaa gttacagccc ttgtttaagg 5280
ggcactgttt cttgtttttg cactgaatca agtctaaccc caacagccac atcctcctat 5340
acctagacat ctcatctcag gaagtggtgg tgggggtagt cagaaggaaa aataactgga 5400
catctttgtg taaaccataa tccacatgtg ccgtaaatga tcttcactcc ttatccgagg 5460
gcaaattcac aaggatcccc aagatccact tttagaagcc attctcatcc a          5511

<210> 373
<211> 3343
<212> DNA
<213> Homo Sapiens

<300> 
<308> GenBank No. M34641
<309> 2001-12-14  

<400> 373
gaattcggga tgtggagctg gaagtgcctc ctcttctggg ctgtgctggt cacagccaca 60
ctctgcaccg ctaggccgtc cccgaccttg cctgaacaag cccagccctg gggagcccct 120
gtggaagtgg agtccttcct ggtccacccc ggtgacctgc tgcagcttcg ctgtcggctg 180
cgggacgatg tgcagagcat caactggctg cgggacgggg tgcagctggc ggaaagcaac 240
cgcacccgca tcacagggga ggaggtggag gtgcaggact ccgtgcccgc agactccggc 300
ctctatgctt gcgtaaccag cagcccctcg ggcagtgaca ccacctactt ctccgtcaat 360
gtttcagatg ctctcccctc ctcggaggat gatgatgatg atgatgactc ctcttcagag 420
gagaaagaaa cagataacac caaaccaaac cccgtagctc catattggac atccccagaa 480
aagatggaaa agaaattgca tgcagtgccg gctgccaaga cagtgaagtt caaatgccct 540
tccagtggga ccccaaaccc cacactgcgc tggttgaaaa atagcaaaga attcaaacct 600
gaccacagaa ttggaggcta caaggtccgt tatgccacct ggagcatcat aatggactct 660
gtggtgccct ctgacaaggg caactacacc tgcattgtgg agaatgagta cggcagcatc 720
aaccacacat accagctgga tgtcgtggag cggtcccctc accggcccat cctgcaagca 780
gggttgcccg ccaacaaaac agtggccctg ggtagcaacg tggagttcat gtgtaaggtg 840
tacagtgacc cgcagccgca catccagtgg ctaaagcaca tcgaggtgaa tgggagcaag 900
attggcccag acaacctgcc ttatgtccag atcttgaaga ctgctggagt taataccacc 960
gacaaagaga tggaggtgct tcacttaaga aatgtctcct ttgaggacgc aggggagtat 1020
acgtgcttgg cgggtaactc tatcggactc tcccatcact ctgcatggtt gaccgttctg 1080
gaagccctgg aagagaggcc ggcagtgatg acctcgcccc tgtacctgga gatcatcatc 1140
tattgcacag gggccttcct catctcctgc atggtggggt cggtcatcgt ctacaagatg 1200
aagagtggta ccaagaagag tgacttccac agccagatgg ctgtgcacaa gctggccaag 1260
agcatccctc tgcgcagaca ggtaacagtg tctgctgact ccagtgcatc catgaactct 1320
ggggttcttc tggttcggcc atcacggctc tcctccagtg ggactcccat gctagcaggg 1380
gtctctgagt atgagcttcc cgaagaccct cgctgggagc tgcctcggga cagactggtc 1440
ttaggcaaac ccctgggaga gggctgcttt gggcaggtgg tgttggcaga ggctatcggg 1500
ctggacaagg acaaacccaa ccgtgtgacc aaagtggctg tgaagatgtt gaagtcggac 1560
gcaacagaga aagacttgtc agacctgatc tcagaaatgg agatgatgaa gatgatcggg 1620
aagcataaga atatcatcaa cctgctgggg gcctgcacgc aggatggtcc cttgtatgtc 1680
atcgtggagt atgcctccaa gggcaacctg cgggagtacc tgcaggcccg gaggccccca 1740
gggctggaat actgctacaa ccccagccac aacccagagg agcagctctc ctccaaggac 1800
ctggtgtcct gcgcctacca ggtggcccga ggcatggagt atctggcctc caagaagtgc 1860
atacaccgag acctggcagc caggaatgtc ctggtgacag aggacaatgt gatgaagata 1920
gcagactttg gcctcgcacg ggacattcac cacatcgact actataaaaa gacaaccaac 1980
ggccgactgc ctgtgaagtg gatggcaccc gaggcattat ttgaccggat ctacacccac 2040
cagagtgatg tgtggtcttt cggggtgctc ctgtgggaga tcttcactct gggcggctcc 2100
ccataccccg gtgtgcctgt ggaggaactt ttcaagctgc tgaaggaggg tcaccgcatg 2160
gacaagccca gtaactgcac caacgagctg tacatgatga tgcgggactg ctggcatgca 2220
gtgccctcac agagacccac cttcaagcag ctggtggaag acctggaccg catcgtggcc 2280
ttgacctcca accaggagta cctggacctg tccatgcccc tggaccagta ctcccccagc 2340
tttcccgaca cccggagctc tacgtgctcc tcaggggagg attccgtctt ctctcatgag 2400
ccgctgcccg aggagccctg cctgccccga cacccagccc agcttgccaa tggcggactc 2460
aaacgccgct gactgccacc cacacgccct ccccagactc caccgtcagc tgtaaccctc 2520
acccacagcc cctgctgggc ccaccacctg tccgtccctg tcccctttcc tgctggcagg 2580
agccggctgc ctaccagggg ccttcctgtg tggcctgcct tcaccccact cagctcacct 2640
ctccctccac ctcctctcca cctgctggtg agaggtgcaa agaggcagat ctttgctgcc 2700
agccacttca tcccctccca gatgttggac caacacccct ccctgccaca gcatcgcctg 2760
gagggcaggg agtgggagcc aatgaacagg catgcaagtg agagcttcct gagctttctc 2820
tgtcggtttg gtctgttttg ccttcaccca taagcccctc gcactctggt ggcaggtgcc 2880
ttgtcctcag ggctacagca gtagggaggt cagtgcttcg tgcctcgatt gaaggtgacc 2940
tctgccccag ataggtggtg cagtggctta ttaattccga tactagtttg ctttgctgac 3000
caaatgcctg gtaccagagg atggtgaggc gaaggccagg ttgggggcag tgttgtggcc 3060
ctggggccag ccccaaactg ggggctctgt atatagctat gaagaaaaca caaagtgtat 3120
aaatctgagt atatatttac atgtcttttt aaaagggtcg ttaccagaga tttacccatc 3180
gggtaagatg ctcctggtgg ctgggaggca tcagttgcta tatattaaaa acaaaaaaga 3240
aaaaaaagga aaatgttttt aaaaaggtca tatatttttt gctacttttg ctgttttatt 3300
tttttaaatt atgttctaaa ctcgtgccgc tcgtgccgaa ttc                   3343

<210> 374
<211> 4587
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM000141
<309> 2004-12-20  

<400> 374
gagcgggcga gggagcgcgc gcggccgcca caaagctcgg gcgccgcggg gctgcatgcg 60
gcgtacctgg cccggcgcgg cgactgctct ccgggctggc gggggccggc cgcgagcccc 120
gggggccccg aggccgcagc ttgcctgcgc gctctgagcc ttcgcaactc gcgagcaaag 180
tttggtggag gcaacgccaa gcctgagtcc tttcttcctc tcgttcccca aatccgaggg 240
cagcccgcgg gcgtcatgcc cgcgctcctc cgcagcctgg ggtacgcgtg aagcccggga 300
ggcttggcgc cggcgaagac ccaaggacca ctcttctgcg tttggagttg ctccccacaa 360
ccccgggctc gtcgctttct ccatcccgac ccacgcgggg cgcggggaca acacaggtcg 420
cggaggagcg ttgccattca agtgactgca gcagcagcgg cagcgcctcg gttcctgagc 480
ccaccgcagg ctgaaggcat tgcgcgtagt ccatgcccgt agaggaagtg tgcagatggg 540
attaacgtcc acatggagat atggaagagg accggggatt ggtaccgtaa ccatggtcag 600
ctggggtcgt ttcatctgcc tggtcgtggt caccatggca accttgtccc tggcccggcc 660
ctccttcagt ttagttgagg ataccacatt agagccagaa gagccaccaa ccaaatacca 720
aatctctcaa ccagaagtgt acgtggctgc gccaggggag tcgctagagg tgcgctgcct 780
gttgaaagat gccgccgtga tcagttggac taaggatggg gtgcacttgg ggcccaacaa 840
taggacagtg cttattgggg agtacttgca gataaagggc gccacgccta gagactccgg 900
cctctatgct tgtactgcca gtaggactgt agacagtgaa acttggtact tcatggtgaa 960
tgtcacagat gccatctcat ccggagatga tgaggatgac accgatggtg cggaagattt 1020
tgtcagtgag aacagtaaca acaagagagc accatactgg accaacacag aaaagatgga 1080
aaagcggctc catgctgtgc ctgcggccaa cactgtcaag tttcgctgcc cagccggggg 1140
gaacccaatg ccaaccatgc ggtggctgaa aaacgggaag gagtttaagc aggagcatcg 1200
cattggaggc tacaaggtac gaaaccagca ctggagcctc attatggaaa gtgtggtccc 1260
atctgacaag ggaaattata cctgtgtggt ggagaatgaa tacgggtcca tcaatcacac 1320
gtaccacctg gatgttgtgg agcgatcgcc tcaccggccc atcctccaag ccggactgcc 1380
ggcaaatgcc tccacagtgg tcggaggaga cgtagagttt gtctgcaagg tttacagtga 1440
tgcccagccc cacatccagt ggatcaagca cgtggaaaag aacggcagta aatacgggcc 1500
cgacgggctg ccctacctca aggttctcaa ggccgccggt gttaacacca cggacaaaga 1560
gattgaggtt ctctatattc ggaatgtaac ttttgaggac gctggggaat atacgtgctt 1620
ggcgggtaat tctattggga tatcctttca ctctgcatgg ttgacagttc tgccagcgcc 1680
tggaagagaa aaggagatta cagcttcccc agactacctg gagatagcca tttactgcat 1740
aggggtcttc ttaatcgcct gtatggtggt aacagtcatc ctgtgccgaa tgaagaacac 1800
gaccaagaag ccagacttca gcagccagcc ggctgtgcac aagctgacca aacgtatccc 1860
cctgcggaga caggtaacag tttcggctga gtccagctcc tccatgaact ccaacacccc 1920
gctggtgagg ataacaacac gcctctcttc aacggcagac acccccatgc tggcaggggt 1980
ctccgagtat gaacttccag aggacccaaa atgggagttt ccaagagata agctgacact 2040
gggcaagccc ctgggagaag gttgctttgg gcaagtggtc atggcggaag cagtgggaat 2100
tgacaaagac aagcccaagg aggcggtcac cgtggccgtg aagatgttga aagatgatgc 2160
cacagagaaa gacctttctg atctggtgtc agagatggag atgatgaaga tgattgggaa 2220
acacaagaat atcataaatc ttcttggagc ctgcacacag gatgggcctc tctatgtcat 2280
agttgagtat gcctctaaag gcaacctccg agaatacctc cgagcccgga ggccacccgg 2340
gatggagtac tcctatgaca ttaaccgtgt tcctgaggag cagatgacct tcaaggactt 2400
ggtgtcatgc acctaccagc tggccagagg catggagtac ttggcttccc aaaaatgtat 2460
tcatcgagat ttagcagcca gaaatgtttt ggtaacagaa aacaatgtga tgaaaatagc 2520
agactttgga ctcgccagag atatcaacaa tatagactat tacaaaaaga ccaccaatgg 2580
gcggcttcca gtcaagtgga tggctccaga agccctgttt gatagagtat acactcatca 2640
gagtgatgtc tggtccttcg gggtgttaat gtgggagatc ttcactttag ggggctcgcc 2700
ctacccaggg attcccgtgg aggaactttt taagctgctg aaggaaggac acagaatgga 2760
taagccagcc aactgcacca acgaactgta catgatgatg agggactgtt ggcatgcagt 2820
gccctcccag agaccaacgt tcaagcagtt ggtagaagac ttggatcgaa ttctcactct 2880
cacaaccaat gaggaatact tggacctcag ccaacctctc gaacagtatt cacctagtta 2940
ccctgacaca agaagttctt gttcttcagg agatgattct gttttttctc cagaccccat 3000
gccttacgaa ccatgccttc ctcagtatcc acacataaac ggcagtgtta aaacatgaat 3060
gactgtgtct gcctgtcccc aaacaggaca gcactgggaa cctagctaca ctgagcaggg 3120
agaccatgcc tcccagagct tgttgtctcc acttgtatat atggatcaga ggagtaaata 3180
attggaaaag taatcagcat atgtgtaaag atttatacag ttgaaaactt gtaatcttcc 3240
ccaggaggag aagaaggttt ctggagcagt ggactgccac aagccaccat gtaacccctc 3300
tcacctgccg tgcgtactgg ctgtggacca gtaggactca aggtggacgt gcgttctgcc 3360
ttccttgtta attttgtaat aattggagaa gatttatgtc agcacacact tacagagcac 3420
aaatgcagta tataggtgct ggatgtatgt aaatatattc aaattatgta taaatatata 3480
ttatatattt acaaggagtt attttttgta ttgattttaa atggatgtcc caatgcacct 3540
agaaaattgg tctctctttt tttaatagct atttgctaaa tgctgttctt acacataatt 3600
tcttaatttt caccgagcag aggtggaaaa atacttttgc tttcagggaa aatggtataa 3660
cgttaattta ttaataaatt ggtaatatac aaaacaatta atcatttata gttttttttg 3720
taatttaagt ggcatttcta tgcaggcagc acagcagact agttaatcta ttgcttggac 3780
ttaactagtt atcagatcct ttgaaaagag aatatttaca atatatgact aatttgggga 3840
aaatgaagtt ttgatttatt tgtgtttaaa tgctgctgtc agacgattgt tcttagacct 3900
cctaaatgcc ccatattaaa agaactcatt cataggaagg tgtttcattt tggtgtgcaa 3960
ccctgtcatt acgtcaacgc aacgtctaac tggacttccc aagataaatg gtaccagcgt 4020
cctcttaaaa gatgccttaa tccattcctt gaggacagac cttagttgaa atgatagcag 4080
aatgtgcttc tctctggcag ctggccttct gcttctgagt tgcacattaa tcagattagc 4140
ctgattctct tcagtgaatt ttgataatgg cttccagact ctttgcgttg gagacgcctg 4200
ttaggatctt caagtcccat catagaaaat tgaaacacag agttgttctg ctgatagttt 4260
tggggatacg tccatctttt taagggattg ctttcatcta attctggcag gacctcacca 4320
aaagatccag cctcatacct acatcagaca aaatatcgcc gttgttcctt ctgtactaaa 4380
gtattgtgtt ttgctttgga aacacccact cactttgcaa tagccgtgca agatgaatgc 4440
agattacact gatcttatgt gttacaaaat tggagaaagt atttaataaa acctgttaat 4500
ttttatactg acaataaaaa tgtttctaca gatattaatg ttaacaagac aaaataaatg 4560
tcacgcaact taaaaaaaaa aaaaaaa                                     4587

<210> 375
<211> 4093
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM000142
<309> 2004-12-20  

<400> 375
cgcgcgctgc ctgaggacgc cgcggccccc gcccccgcca tgggcgcccc tgcctgcgcc 60
ctcgcgctct gcgtggccgt ggccatcgtg gccggcgcct cctcggagtc cttggggacg 120
gagcagcgcg tcgtggggcg agcggcagaa gtcccgggcc cagagcccgg ccagcaggag 180
cagttggtct tcggcagcgg ggatgctgtg gagctgagct gtcccccgcc cgggggtggt 240
cccatggggc ccactgtctg ggtcaaggat ggcacagggc tggtgccctc ggagcgtgtc 300
ctggtggggc cccagcggct gcaggtgctg aatgcctccc acgaggactc cggggcctac 360
agctgccggc agcggctcac gcagcgcgta ctgtgccact tcagtgtgcg ggtgacagac 420
gctccatcct cgggagatga cgaagacggg gaggacgagg ctgaggacac aggtgtggac 480
acaggggccc cttactggac acggcccgag cggatggaca agaagctgct ggccgtgccg 540
gccgccaaca ccgtccgctt ccgctgccca gccgctggca accccactcc ctccatctcc 600
tggctgaaga acggcaggga gttccgcggc gagcaccgca ttggaggcat caagctgcgg 660
catcagcagt ggagcctggt catggaaagc gtggtgccct cggaccgcgg caactacacc 720
tgcgtcgtgg agaacaagtt tggcagcatc cggcagacgt acacgctgga cgtgctggag 780
cgctccccgc accggcccat cctgcaggcg gggctgccgg ccaaccagac ggcggtgctg 840
ggcagcgacg tggagttcca ctgcaaggtg tacagtgacg cacagcccca catccagtgg 900
ctcaagcacg tggaggtgaa cggcagcaag gtgggcccgg acggcacacc ctacgttacc 960
gtgctcaaga cggcgggcgc taacaccacc gacaaggagc tagaggttct ctccttgcac 1020
aacgtcacct ttgaggacgc cggggagtac acctgcctgg cgggcaattc tattgggttt 1080
tctcatcact ctgcgtggct ggtggtgctg ccagccgagg aggagctggt ggaggctgac 1140
gaggcgggca gtgtgtatgc aggcatcctc agctacgggg tgggcttctt cctgttcatc 1200
ctggtggtgg cggctgtgac gctctgccgc ctgcgcagcc cccccaagaa aggcctgggc 1260
tcccccaccg tgcacaagat ctcccgcttc ccgctcaagc gacaggtgtc cctggagtcc 1320
aacgcgtcca tgagctccaa cacaccactg gtgcgcatcg caaggctgtc ctcaggggag 1380
ggccccacgc tggccaatgt ctccgagctc gagctgcctg ccgaccccaa atgggagctg 1440
tctcgggccc ggctgaccct gggcaagccc cttggggagg gctgcttcgg ccaggtggtc 1500
atggcggagg ccatcggcat tgacaaggac cgggccgcca agcctgtcac cgtagccgtg 1560
aagatgctga aagacgatgc cactgacaag gacctgtcgg acctggtgtc tgagatggag 1620
atgatgaaga tgatcgggaa acacaaaaac atcatcaacc tgctgggcgc ctgcacgcag 1680
ggcgggcccc tgtacgtgct ggtggagtac gcggccaagg gtaacctgcg ggagtttctg 1740
cgggcgcggc ggcccccggg cctggactac tccttcgaca cctgcaagcc gcccgaggag 1800
cagctcacct tcaaggacct ggtgtcctgt gcctaccagg tggcccgggg catggagtac 1860
ttggcctccc agaagtgcat ccacagggac ctggctgccc gcaatgtgct ggtgaccgag 1920
gacaacgtga tgaagatcgc agacttcggg ctggcccggg acgtgcacaa cctcgactac 1980
tacaagaaga caaccaacgg ccggctgccc gtgaagtgga tggcgcctga ggccttgttt 2040
gaccgagtct acactcacca gagtgacgtc tggtcctttg gggtcctgct ctgggagatc 2100
ttcacgctgg ggggctcccc gtaccccggc atccctgtgg aggagctctt caagctgctg 2160
aaggagggcc accgcatgga caagcccgcc aactgcacac acgacctgta catgatcatg 2220
cgggagtgct ggcatgccgc gccctcccag aggcccacct tcaagcagct ggtggaggac 2280
ctggaccgtg tccttaccgt gacgtccacc gacgagtacc tggacctgtc ggcgcctttc 2340
gagcagtact ccccgggtgg ccaggacacc cccagctcca gctcctcagg ggacgactcc 2400
gtgtttgccc acgacctgct gcccccggcc ccacccagca gtgggggctc gcggacgtga 2460
agggccactg gtccccaaca atgtgagggg tccctagcag ccctccctgc tgctggtgca 2520
cagccactcc ccggcatgag actcagtgca gatggagaga cagctacaca gagctttggt 2580
ctgtgtgtgt gtgtgtgcgt gtgtgtgtgt gtgtgcacat ccgcgtgtgc ctgtgtgcgt 2640
gcgcatcttg cctccaggtg cagaggtacc ctgggtgtcc ccgctgctgt gcaacggtct 2700
cctgactggt gctgcagcac cgaggggcct ttgttctggg gggacccagt gcagaatgta 2760
agtgggccca cccggtggga ccccgtgggg cagggagctg ggcccgacat ggctcggcct 2820
ctgcctttgc accacgggac atcacagggt gcgctcggcc cctcccacac ccaaagctga 2880
gcctgcaggg aagccccaca tgtccagcac cttgtgcctg gggtgttagt ggcaccgcct 2940
ccccacctcc aggctttccc acttcccacc ctgcccctca gagactgaaa ttacgggtac 3000
ctgaagatgg gagcctttac cttttatgca aaaggtttat tccggaaact agtgtacatt 3060
tctataaata gatgctgtgt atatggtata tatacatata tatatataac atatatggaa 3120
gaggaaaagg ctggtacaac ggaggcctgc gaccctgggg gcacaggagg caggcatggc 3180
cctgggcggg gcgtgggggg gcgtggaggg aggccccagg ggtctcaccc atgcaagcag 3240
aggaccaggg ctttttctgg caccgcagtt ttgttttaaa actggacctg tatatttgta 3300
aagctattta tgggcccctg gcactcttgt tcccacaccc caacacttcc agcatttagc 3360
tggccacatg gcggagagtt ttaattttta acttattgac aaccgagaag gtttatcccg 3420
ccgatagagg gacggccaag aatgtacgtc cagcctgccc cggagctgga ggatcccctc 3480
caagcctaaa aggttgttaa tagttggagg tgattccagt gaagatattt tatttgcttt 3540
gtcctttttc aggagaatta gatttctata ggatttttct ttaggagatt tattttttgg 3600
acttcaaagc aagctggtat tttcatacaa attcttctaa ttgctgtgtg tcccaggcag 3660
ggagacggtt tccagggagg ggccggccct gtgtgcaggt tccgatgtta ttagatgtta 3720
caagtttata tatatctata tatataattt attgagtttt tacaagatgt atttgttgta 3780
gacttaacac ttcttacgca atgcttctag agttttatag cctggactgc tacctttcaa 3840
agcttggagg gaagccgtga attcagttgg ttcgttctgt actgttactg ggccctgagt 3900
ctgggcagct gtcccttgct tgcctgcagg gccatggctc agggtggtct cttcttgggg 3960
cccagtgcat ggtggccaga ggtgtcaccc aaaccggcag gtgcgatttt gttaacccag 4020
cgacgaactt tccgaaaaat aaagacacct ggttgctaac ctgaaaaaaa aaaaaaaaaa 4080
aaaaaaaaaa aaa                                                    4093

<210> 376
<211> 3015
<212> DNA
<213> Homo Sapiens

<300> 
<308> GenBank NM_002011
<309> 2004-05-20  

<400> 376
ccgaggagcg ctcgggctgt ctgcggaccc tgccgcgtgc aggggtcgcg gccggctgga 60
gctgggagtg aggcggcgga ggagccaggt gaggaggagc caggaaggca gttggtggga 120
agtccagctt gggtccctga gagctgtgag aaggagatgc ggctgctgct ggccctgttg 180
ggggtcctgc tgagtgtgcc tgggcctcca gtcttgtccc tggaggcctc tgaggaagtg 240
gagcttgagc cctgcctggc tcccagcctg gagcagcaag agcaggagct gacagtagcc 300
cttgggcagc ctgtgcggct gtgctgtggg cgggctgagc gtggtggcca ctggtacaag 360
gagggcagtc gcctggcacc tgctggccgt gtacggggct ggaggggccg cctagagatt 420
gccagcttcc tacctgagga tgctggccgc tacctctgcc tggcacgagg ctccatgatc 480
gtcctgcaga atctcacctt gattacaggt gactccttga cctccagcaa cgatgatgag 540
gaccccaagt cccataggga cctctcgaat aggcacagtt acccccagca agcaccctac 600
tggacacacc cccagcgcat ggagaagaaa ctgcatgcag tacctgcggg gaacaccgtc 660
aagttccgct gtccagctgc aggcaacccc acgcccacca tccgctggct taaggatgga 720
caggcctttc atggggagaa ccgcattgga ggcattcggc tgcgccatca gcactggagt 780
ctcgtgatgg agagcgtggt gccctcggac cgcggcacat acacctgcct ggtagagaac 840
gctgtgggca gcatccgcta taactacctg ctagatgtgc tggagcggtc cccgcaccgg 900
cccatcctgc aggccgggct cccggccaac accacagccg tggtgggcag cgacgtggag 960
ctgctgtgca aggtgtacag cgatgcccag ccccacatcc agtggctgaa gcacatcgtc 1020
atcaacggca gcagcttcgg agccgacggt ttcccctatg tgcaagtcct aaagactgca 1080
gacatcaata gctcagaggt ggaggtcctg tacctgcgga acgtgtcagc cgaggacgca 1140
ggcgagtaca cctgcctcgc aggcaattcc atcggcctct cctaccagtc tgcctggctc 1200
acggtgctgc cagaggagga ccccacatgg accgcagcag cgcccgaggc caggtatacg 1260
gacatcatcc tgtacgcgtc gggctccctg gccttggctg tgctcctgct gctggccggg 1320
ctgtatcgag ggcaggcgct ccacggccgg cacccccgcc cgcccgccac tgtgcagaag 1380
ctctcccgct tccctctggc ccgacagttc tccctggagt caggctcttc cggcaagtca 1440
agctcatccc tggtacgagg cgtgcgtctc tcctccagcg gccccgcctt gctcgccggc 1500
ctcgtgagtc tagatctacc tctcgaccca ctatgggagt tcccccggga caggctggtg 1560
cttgggaagc ccctaggcga gggctgcttt ggccaggtag tacgtgcaga ggcctttggc 1620
atggaccctg cccggcctga ccaagccagc actgtggccg tcaagatgct caaagacaac 1680
gcctctgaca aggacctggc cgacctggtc tcggagatgg aggtgatgaa gctgatcggc 1740
cgacacaaga acatcatcaa cctgcttggt gtctgcaccc aggaagggcc cctgtacgtg 1800
atcgtggagt gcgccgccaa gggaaacctg cgggagttcc tgcgggcccg gcgcccccca 1860
ggccccgacc tcagccccga cggtcctcgg agcagtgagg ggccgctctc cttcccagtc 1920
ctggtctcct gcgcctacca ggtggcccga ggcatgcagt atctggagtc ccggaagtgt 1980
atccaccggg acctggctgc ccgcaatgtg ctggtgactg aggacaatgt gatgaagatt 2040
gctgactttg ggctggcccg cggcgtccac cacattgact actataagaa aaccagcaac 2100
ggccgcctgc ctgtgaagtg gatggcgccc gaggccttgt ttgaccgggt gtacacacac 2160
cagagtgacg tgtggtcttt tgggatcctg ctatgggaga tcttcaccct cgggggctcc 2220
ccgtatcctg gcatcccggt ggaggagctg ttctcgctgc tgcgggaggg acatcggatg 2280
gaccgacccc cacactgccc cccagagctg tacgggctga tgcgtgagtg ctggcacgca 2340
gcgccctccc agaggcctac cttcaagcag ctggtggagg cgctggacaa ggtcctgctg 2400
gccgtctctg aggagtacct cgacctccgc ctgaccttcg gaccctattc cccctctggt 2460
ggggacgcca gcagcacctg ctcctccagc gattctgtct tcagccacga ccccctgcca 2520
ttgggatcca gctccttccc cttcgggtct ggggtgcaga catgagcaag gctcaaggct 2580
gtgcaggcac ataggctggt ggccttgggc cttggggctc agccacagcc tgacacagtg 2640
ctcgaccttg atagcatggg gcccctggcc cagagttgct gtgccgtgtc caagggccgt 2700
gcccttgccc ttggagctgc cgtgcctgtg tcctgatggc ccaaatgtca gggttctgct 2760
cggcttcttg gaccatggcg cttagtcccc atcccgggtt tggctgagcc tggctggaga 2820
gctgctatgc taaacctcct gcctcccaat accagcagga ggttctgggc ctctgaaccc 2880
cctttcccca cacctccccc tgctgctgct gccccagcgt cttgacggga gcattggccc 2940
ctgagcccag agaagctgga agcctgccga aaacaggagc aaatggcgtt ttataaatta 3000
tttttttgaa ataaa                                                  3015

<210> 377
<211> 6641
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM000245
<309> 2004-10-28  

<400> 377
gccctcgccg cccgcggcgc cccgagcgct ttgtgagcag atgcggagcc gagtggaggg 60
cgcgagccag atgcggggcg acagctgact tgctgagagg aggcggggag gcgcggagcg 120
cgcgtgtggt ccttgcgccg ctgacttctc cactggttcc tgggcaccga aagataaacc 180
tctcataatg aaggcccccg ctgtgcttgc acctggcatc ctcgtgctcc tgtttacctt 240
ggtgcagagg agcaatgggg agtgtaaaga ggcactagca aagtccgaga tgaatgtgaa 300
tatgaagtat cagcttccca acttcaccgc ggaaacaccc atccagaatg tcattctaca 360
tgagcatcac attttccttg gtgccactaa ctacatttat gttttaaatg aggaagacct 420
tcagaaggtt gctgagtaca agactgggcc tgtgctggaa cacccagatt gtttcccatg 480
tcaggactgc agcagcaaag ccaatttatc aggaggtgtt tggaaagata acatcaacat 540
ggctctagtt gtcgacacct actatgatga tcaactcatt agctgtggca gcgtcaacag 600
agggacctgc cagcgacatg tctttcccca caatcatact gctgacatac agtcggaggt 660
tcactgcata ttctccccac agatagaaga gcccagccag tgtcctgact gtgtggtgag 720
cgccctggga gccaaagtcc tttcatctgt aaaggaccgg ttcatcaact tctttgtagg 780
caataccata aattcttctt atttcccaga tcatccattg cattcgatat cagtgagaag 840
gctaaaggaa acgaaagatg gttttatgtt tttgacggac cagtcctaca ttgatgtttt 900
acctgagttc agagattctt accccattaa gtatgtccat gcctttgaaa gcaacaattt 960
tatttacttc ttgacggtcc aaagggaaac tctagatgct cagacttttc acacaagaat 1020
aatcaggttc tgttccataa actctggatt gcattcctac atggaaatgc ctctggagtg 1080
tattctcaca gaaaagagaa aaaagagatc cacaaagaag gaagtgttta atatacttca 1140
ggctgcgtat gtcagcaagc ctggggccca gcttgctaga caaataggag ccagcctgaa 1200
tgatgacatt cttttcgggg tgttcgcaca aagcaagcca gattctgccg aaccaatgga 1260
tcgatctgcc atgtgtgcat tccctatcaa atatgtcaac gacttcttca acaagatcgt 1320
caacaaaaac aatgtgagat gtctccagca tttttacgga cccaatcatg agcactgctt 1380
taataggaca cttctgagaa attcatcagg ctgtgaagcg cgccgtgatg aatatcgaac 1440
agagtttacc acagctttgc agcgcgttga cttattcatg ggtcaattca gcgaagtcct 1500
cttaacatct atatccacct tcattaaagg agacctcacc atagctaatc ttgggacatc 1560
agagggtcgc ttcatgcagg ttgtggtttc tcgatcagga ccatcaaccc ctcatgtgaa 1620
ttttctcctg gactcccatc cagtgtctcc agaagtgatt gtggagcata cattaaacca 1680
aaatggctac acactggtta tcactgggaa gaagatcacg aagatcccat tgaatggctt 1740
gggctgcaga catttccagt cctgcagtca atgcctctct gccccaccct ttgttcagtg 1800
tggctggtgc cacgacaaat gtgtgcgatc ggaggaatgc ctgagcggga catggactca 1860
acagatctgt ctgcctgcaa tctacaaggt tttcccaaat agtgcacccc ttgaaggagg 1920
gacaaggctg accatatgtg gctgggactt tggatttcgg aggaataata aatttgattt 1980
aaagaaaact agagttctcc ttggaaatga gagctgcacc ttgactttaa gtgagagcac 2040
gatgaataca ttgaaatgca cagttggtcc tgccatgaat aagcatttca atatgtccat 2100
aattatttca aatggccacg ggacaacaca atacagtaca ttctcctatg tggatcctgt 2160
aataacaagt atttcgccga aatacggtcc tatggctggt ggcactttac ttactttaac 2220
tggaaattac ctaaacagtg ggaattctag acacatttca attggtggaa aaacatgtac 2280
tttaaaaagt gtgtcaaaca gtattcttga atgttatacc ccagcccaaa ccatttcaac 2340
tgagtttgct gttaaattga aaattgactt agccaaccga gagacaagca tcttcagtta 2400
ccgtgaagat cccattgtct atgaaattca tccaaccaaa tcttttatta gtggtgggag 2460
cacaataaca ggtgttggga aaaacctgaa ttcagttagt gtcccgagaa tggtcataaa 2520
tgtgcatgaa gcaggaagga actttacagt ggcatgtcaa catcgctcta attcagagat 2580
aatctgttgt accactcctt ccctgcaaca gctgaatctg caactccccc tgaaaaccaa 2640
agcctttttc atgttagatg ggatcctttc caaatacttt gatctcattt atgtacataa 2700
tcctgtgttt aagccttttg aaaagccagt gatgatctca atgggcaatg aaaatgtact 2760
ggaaattaag ggaaatgata ttgaccctga agcagttaaa ggtgaagtgt taaaagttgg 2820
aaataagagc tgtgagaata tacacttaca ttctgaagcc gttttatgca cggtccccaa 2880
tgacctgctg aaattgaaca gcgagctaaa tatagagtgg aagcaagcaa tttcttcaac 2940
cgtccttgga aaagtaatag ttcaaccaga tcagaatttc acaggattga ttgctggtgt 3000
tgtctcaata tcaacagcac tgttattact acttgggttt ttcctgtggc tgaaaaagag 3060
aaagcaaatt aaagatctgg gcagtgaatt agttcgctac gatgcaagag tacacactcc 3120
tcatttggat aggcttgtaa gtgcccgaag tgtaagccca actacagaaa tggtttcaaa 3180
tgaatctgta gactaccgag ctacttttcc agaagatcag tttcctaatt catctcagaa 3240
cggttcatgc cgacaagtgc agtatcctct gacagacatg tcccccatcc taactagtgg 3300
ggactctgat atatccagtc cattactgca aaatactgtc cacattgacc tcagtgctct 3360
aaatccagag ctggtccagg cagtgcagca tgtagtgatt gggcccagta gcctgattgt 3420
gcatttcaat gaagtcatag gaagagggca ttttggttgt gtatatcatg ggactttgtt 3480
ggacaatgat ggcaagaaaa ttcactgtgc tgtgaaatcc ttgaacagaa tcactgacat 3540
aggagaagtt tcccaatttc tgaccgaggg aatcatcatg aaagatttta gtcatcccaa 3600
tgtcctctcg ctcctgggaa tctgcctgcg aagtgaaggg tctccgctgg tggtcctacc 3660
atacatgaaa catggagatc ttcgaaattt cattcgaaat gagactcata atccaactgt 3720
aaaagatctt attggctttg gtcttcaagt agccaaaggc atgaaatatc ttgcaagcaa 3780
aaagtttgtc cacagagact tggctgcaag aaactgtatg ctggatgaaa aattcacagt 3840
caaggttgct gattttggtc ttgccagaga catgtatgat aaagaatact atagtgtaca 3900
caacaaaaca ggtgcaaagc tgccagtgaa gtggatggct ttggaaagtc tgcaaactca 3960
aaagtttacc accaagtcag atgtgtggtc ctttggcgtg ctcctctggg agctgatgac 4020
aagaggagcc ccaccttatc ctgacgtaaa cacctttgat ataactgttt acttgttgca 4080
agggagaaga ctcctacaac ccgaatactg cccagacccc ttatatgaag taatgctaaa 4140
atgctggcac cctaaagccg aaatgcgccc atccttttct gaactggtgt cccggatatc 4200
agcgatcttc tctactttca ttggggagca ctatgtccat gtgaacgcta cttatgtgaa 4260
cgtaaaatgt gtcgctccgt atccttctct gttgtcatca gaagataacg ctgatgatga 4320
ggtggacaca cgaccagcct ccttctggga gacatcatag tgctagtact atgtcaaagc 4380
aacagtccac actttgtcca atggtttttt cactgcctga cctttaaaag gccatcgata 4440
ttctttgctc ttgccaaaat tgcactatta taggacttgt attgttattt aaattactgg 4500
attctaagga atttcttatc tgacagagca tcagaaccag aggcttggtc ccacaggcca 4560
cggaccaatg gcctgcagcc gtgacaacac tcctgtcata ttggagtcca aaacttgaat 4620
tctgggttga attttttaaa aatcaggtac cacttgattt catatgggaa attgaagcag 4680
gaaatattga gggcttcttg atcacagaaa actcagaaga gatagtaatg ctcaggacag 4740
gagcggcagc cccagaacag gccactcatt tagaattcta gtgtttcaaa acacttttgt 4800
gtgttgtatg gtcaataaca tttttcatta ctgatggtgt cattcaccca ttaggtaaac 4860
attccctttt aaatgtttgt ttgttttttg agacaggatc tcactctgtt gccagggctg 4920
tagtgcagtg gtgtgatcat agctcactgc aacctccacc tcccaggctc aagcctcccg 4980
aatagctggg actacaggcg cacaccacca tccccggcta atttttgtat tttttgtaga 5040
gacggggttt tgccatgttg ccaaggctgg tttcaaactc ctggactcaa gaaatccacc 5100
cacctcagcc tcccaaagtg ctaggattac aggcatgagc cactgcgccc agcccttata 5160
aatttttgta tagacattcc tttggttgga agaatattta taggcaatac agtcaaagtt 5220
tcaaaatagc atcacacaaa acatgtttat aaatgaacag gatgtaatgt acatagatga 5280
cattaagaaa atttgtatga aataatttag tcatcatgaa atatttagtt gtcatataaa 5340
aacccactgt ttgagaatga tgctactctg atctaatgaa tgtgaacatg tagatgtttt 5400
gtgtgtattt ttttaaatga aaactcaaaa taagacaagt aatttgttga taaatatttt 5460
taaagataac tcagcatgtt tgtaaagcag gatacatttt actaaaaggt tcattggttc 5520
caatcacagc tcataggtag agcaaagaaa gggtggatgg attgaaaaga ttagcctctg 5580
tctcggtggc aggttcccac ctcgcaagca attggaaaca aaacttttgg ggagttttat 5640
tttgcattag ggtgtgtttt atgttaagca aaacatactt tagaaacaaa tgaaaaaggc 5700
aattgaaaat cccagctatt tcacctagat ggaatagcca ccctgagcag aactttgtga 5760
tgcttcattc tgtggaattt tgtgcttgct actgtatagt gcatgtggtg taggttactc 5820
taactggttt tgtcgacgta aacatttaaa gtgttatatt ttttataaaa atgtttattt 5880
ttaatgatat gagaaaaatt ttgttaggcc acaaaaacac tgcactgtga acattttaga 5940
aaaggtatgt cagactggga ttaatgacag catgattttc aatgactgta aattgcgata 6000
aggaaatgta ctgattgcca atacacccca ccctcattac atcatcagga cttgaagcca 6060
agggttaacc cagcaagcta caaagagggt gtgtcacact gaaactcaat agttgagttt 6120
ggctgttgtt gcaggaaaat gattataact aaaagctctc tgatagtgca gagacttacc 6180
agaagacaca aggaattgta ctgaagagct attacaatcc aaatattgcc gtttcataaa 6240
tgtaataagt aatactaatt cacagagtat tgtaaatggt ggatgacaaa agaaaatctg 6300
ctctgtggaa agaaagaact gtctctacca gggtcaagag catgaacgca tcaatagaaa 6360
gaactcgggg aaacatccca tcaacaggac tacacacttg tatatacatt cttgagaaca 6420
ctgcaatgtg aaaatcacgt ttgctattta taaacttgtc cttagattaa tgtgtctgga 6480
cagattgtgg gagtaagtga ttcttctaag aattagatac ttgtcactgc ctatacctgc 6540
agctgaactg aatggtactt cgtatgttaa tagttgttct gataaatcat gcaattaaag 6600
taaagtgatg caacatcttg taaaaaaaaa aaaaaaaaaa a                     6641

<210> 378
<211> 4541
<212> DNA
<213> Homo Sapiens

<300> 
<308> GenBank No. NM002447
<309> 2004-10-28  

<400> 378
ggatcctcta gggtcccagc tcgcctcgat ggagctcctc ccgccgctgc ctcagtcctt 60
cctgttgctg ctgctgttgc ctgccaagcc cgcggcgggc gaggactggc agtgcccgcg 120
caccccctac gcggcctctc gcgactttga cgtgaagtac gtggtgccca gcttctccgc 180
cggaggcctg gtacaggcca tggtgaccta cgagggcgac agaaatgaga gtgctgtgtt 240
tgtagccata cgcaatcgcc tgcatgtgct tgggcctgac ctgaagtctg tccagagcct 300
ggccacgggc cctgctggag accctggctg ccagacgtgt gcagcctgtg gcccaggacc 360
ccacggccct cccggtgaca cagacacaaa ggtgctggtg ctggatcccg cgctgcctgc 420
gctggtcagt tgtggctcca gcctgcaggg ccgctgcttc ctgcatgacc tagagcccca 480
agggacagcc gtgcatctgg cagcgccagc ctgcctcttc tcagcccacc ataaccggcc 540
cgatgactgc cccgactgtg tggccagccc attgggcacc cgtgtaactg tggttgagca 600
aggccaggcc tcctatttct acgtggcatc ctcactggac gcagccgtgg ctggcagctt 660
cagcccacgc tcagtgtcta tcaggcgtct caaggctgac gcctcgggat tcgcaccggg 720
ctttgtggcg ttgtcagtgc tgcccaagca tcttgtctcc tacagtattg aatacgtgca 780
cagcttccac acgggagcct tcgtatactt cctgactgta cagccggcca gcgtgacaga 840
tgatcctagt gccctgcaca cacgcctggc acggcttagc gccactgagc cagagttggg 900
tgactatcgg gagctggtcc tcgactgcag atttgctcca aaacgcaggc gccggggggc 960
cccagaaggc ggacagccct accctgtgct gcaggtggcc cactccgctc cagtgggtgc 1020
ccaacttgcc actgagctga gcatcgccga gggccaggaa gtactatttg gggtctttgt 1080
gactggcaag gatggtggtc ctggcgtggg ccccaactct gtcgtctgtg ccttccccat 1140
tgacctgctg gacacactaa ttgatgaggg tgtggagcgc tgttgtgaat ccccagtcca 1200
tccaggcctc cggcgaggcc tcgacttctt ccagtcgccc agtttttgcc ccaacccgcc 1260
tggcctggaa gccctcagcc ccaacaccag ctgccgccac ttccctctgc tggtcagtag 1320
cagcttctca cgtgtggacc tattcaatgg gctgttggga ccagtacagg tcactgcatt 1380
gtatgtgaca cgccttgaca acgtcacagt ggcacacatg ggcacaatgg atgggcgtat 1440
cctgcaggtg gagctggtca ggtcactaaa ctacttgctg tatgtgtcca acttctcact 1500
gggtgacagt gggcagcccg tgcagcggga tgtcagtcgt cttggggacc acctactctt 1560
tgcctctggg gaccaggttt tccaggtacc tatccgaggc cctggctgcc gccacttcct 1620
gacctgtggg cgttgcctaa gggcatggca tttcatgggc tgtggctggt gtgggaacat 1680
gtgcggccag cagaaggagt gtcctggctc ctggcaacag gaccactgcc cacctaagct 1740
tactgagttc cacccccaca gtggacctct aaggggcagt acaaggctga ccctgtgtgg 1800
ctccaacttc taccttcacc cttctggtct ggtgcctgag ggaacccatc aggtcactgt 1860
gggccaaagt ccctgccggc cactgcccaa ggacagctca aaactcagac cagtgccccg 1920
gaaagacttt gtagaggagt ttgagtgtga actggagccc ttgggcaccc aggcagtggg 1980
gcctaccaac gtcagcctca ccgtgactaa catgccaccg ggcaagcact tccgggtaga 2040
cggcacctcc gtgctgagag gcttctcttt catggagcca gtgctgatag cagtgcaacc 2100
cctctttggc ccacgggcag gaggcacctg tctcactctt gaaggccaga gtctgtctgt 2160
aggcaccagc cgggctgtgc tggtcaatgg gactgagtgt ctgctagcac gggtcagtga 2220
ggggcagctt ttatgtgcca caccccctgg ggccacggtg gccagtgtcc cccttagcct 2280
gcaggtgggg ggtgcccagg tacctggttc ctggaccttc cagtacagag aagaccctgt 2340
cgtgctaagc atcagcccca actgtggcta catcaactcc cacatcacca tctgtggcca 2400
gcatctaact tcagcatggc acttagtgct gtcattccat gacgggctta gggcagtgga 2460
aagcaggtgt gagaggcagc ttccagagca gcagctgtgc cgccttcctg aatatgtggt 2520
ccgagacccc cagggatggg tggcagggaa tctgagtgcc cgaggggatg gagctgctgg 2580
ctttacactg cctggctttc gcttcctacc cccaccccat ccacccagtg ccaacctagt 2640
tccactgaag cctgaggagc atgccattaa gtttgagtat attgggctgg gcgctgtggc 2700
tgactgtgtg ggtatcaacg tgaccgtggg tggtgagagc tgccagcacg agttccgggg 2760
ggacatggtt gtctgccccc tgcccccatc cctgcagctt ggccaggatg gtgccccatt 2820
gcaggtctgc gtagatggtg aatgtcatat cctgggtaga gtggtgcggc cagggccaga 2880
tggggtccca cagagcacgc tccttggtat cctgctgcct ttgctgctgc ttgtggctgc 2940
actggcgact gcactggtct tcagctactg gtggcggagg aagcagctag ttcttcctcc 3000
caacctgaat gacctggcat ccctggacca gactgctgga gccacacccc tgcctattct 3060
gtactcgggc tctgactaca gaagtggcct tgcactccct gccattgatg gtctggattc 3120
caccacttgt gtccatggag catccttctc cgatagtgaa gatgaatcct gtgtgccact 3180
gctgcggaaa gagtccatcc agctaaggga cctggactct gcgctcttgg ctgaggtcaa 3240
ggatgtgctg attccccatg agcgggtggt cacccacagt gaccgagtca ttggcaaagg 3300
ccactttgga gttgtctacc acggagaata catagaccag gcccagaatc gaatccaatg 3360
tgccatcaag tcactaagtc gcatcacaga gatgcagcag gtggaggcct tcctgcgaga 3420
ggggctgctc atgcgtggcc tgaaccaccc gaatgtgctg gctctcattg gtatcatgtt 3480
gccacctgag ggcctgcccc atgtgctgct gccctatatg tgccacggtg acctgctcca 3540
gttcatccgc tcacctcagc ggaaccccac cgtgaaggac ctcatcagct ttggcctgca 3600
ggtagcccgc ggcatggagt acctggcaga gcagaagttt gtgcacaggg acctggctgc 3660
gcggaactgc atgctggacg agtcattcac agtcaaggtg gctgactttg gtttggcccg 3720
cgacatcctg gacagggagt actatagtgt tcaacagcat cgccacgctc gcctacctgt 3780
gaagtggatg gcgctggaga gcctgcagac ctatagattt accaccaagt ctgatgtgtg 3840
gtcatttggt gtgctgctgt gggaactgct gacacggggt gccccaccat accgccacat 3900
tgaccctttt gaccttaccc acttcctggc ccagggtcgg cgcctgcccc agcctgagta 3960
ttgccctgat tctctgtacc aagtgatgca gcaatgctgg gaggcagacc cagcagtgcg 4020
acccaccttc agagtactag tgggggaggt ggagcagata gtgtctgcac tgcttgggga 4080
ccattatgtg cagctgccag caacctacat gaacttgggc cccagcacct cgcatgagat 4140
gaatgtgcgt ccagaacagc cgcagttctc acccatgcca gggaatgtac gccggccccg 4200
gccactctca gagcctcctc ggcccacttg acttagttct tgggctggac ctgcttagct 4260
gccttgagct aaccccaagg ctgcctctgg gccatgccag gccagagcag tggccctcca 4320
ccttgttcct gccctttaac tttcagaggc aataggtaaa tgggcccatt aggtccctca 4380
ctccacagag tgagccagtg agggcagtcc tgcaacatgt atttatggag tgcctgctgt 4440
ggaccctgtc ttctgggcac agtggactca gcagtgacca caccaacact gacccttgaa 4500
ccaataaagg aacaaatgac tattaaagca caaaaaaaaa a                     4541

<210> 379
<211> 3985
<212> DNA
<213> Homo Sapiens

<300> 
<308> GenBank No. NM005211
<309> 2004-10-26  

<400> 379
gaagggcaga cagagtgtcc aaaagcgtga gagcacgaag tgaggagaag gtggagaaga 60
gagaagagga agaggaagag gaagagagga agcggaggga actgcggcca ggctaaaagg 120
ggaagaagag gatcagccca aggaggagga agaggaaaac aagacaaaca gccagtgcag 180
aggagaggaa cgtgtgtcca gtgtcccgat ccctgcggag ctagtagctg agagctctgt 240
gccctgggca ccttgcagcc ctgcacctgc ctgccacttc cccaccgagg ccatgggccc 300
aggagttctg ctgctcctgc tggtggccac agcttggcat ggtcagggaa tcccagtgat 360
agagcccagt gtccctgagc tggtcgtgaa gccaggagca acggtgacct tgcgatgtgt 420
gggcaatggc agcgtggaat gggatggccc cccatcacct cactggaccc tgtactctga 480
tggctccagc agcatcctca gcaccaacaa cgctaccttc caaaacacgg ggacctatcg 540
ctgcactgag cctggagacc ccctgggagg cagcgccgcc atccacctct atgtcaaaga 600
ccctgcccgg ccctggaacg tgctagcaca ggaggtggtc gtgttcgagg accaggacgc 660
actactgccc tgtctgctca cagacccggt gctggaagca ggcgtctcgc tggtgcgtgt 720
gcgtggccgg cccctcatgc gccacaccaa ctactccttc tcgccctggc atggcttcac 780
catccacagg gccaagttca ttcagagcca ggactatcaa tgcagtgccc tgatgggtgg 840
caggaaggtg atgtccatca gcatccggct gaaagtgcag aaagtcatcc cagggccccc 900
agccttgaca ctggtgcctg cagagctggt gcggattcga ggggaggctg cccagatcgt 960
gtgctcagcc agcagcgttg atgttaactt tgatgtcttc ctccaacaca acaacaccaa 1020
gctcgcaatc cctcaacaat ctgactttca taataaccgt taccaaaaag tcctgaccct 1080
caacctcgat caagtagatt tccaacatgc cggcaactac tcctgcgtgg ccagcaacgt 1140
gcagggcaag cactccacct ccatgttctt ccgggtggta gagagtgcct acttgaactt 1200
gagctctgag cagaacctca tccaggaggt gaccgtgggg gaggggctca acctcaaagt 1260
catggtggag gcctacccag gcctgcaagg ttttaactgg acctacctgg gacccttttc 1320
tgaccaccag cctgagccca agcttgctaa tgctaccacc aaggacacat acaggcacac 1380
cttcaccctc tctctgcccc gcctgaagcc ctctgaggct ggccgctact ccttcctggc 1440
cagaaaccca ggaggctgga gagctctgac gtttgagctc acccttcgat accccccaga 1500
ggtaagcgtc atatggacat tcatcaacgg ctctggcacc cttttgtgtg ctgcctctgg 1560
gtacccccag cccaacgtga catggctgca gtgcagtggc cacactgata ggtgtgatga 1620
ggcccaagtg ctgcaggtct gggatgaccc ataccctgag gtcctgagcc aggagccctt 1680
ccacaaggtg acggtgcaga gcctgctgac tgttgagacc ttagagcaca accaaaccta 1740
cgagtgcagg gcccacaaca gcgtggggag tggctcctgg gccttcatac ccatctctgc 1800
aggagcccac acgcatcccc cggatgagtt cctcttcaca ccagtggtgg tcgcctgcat 1860
gtccatcatg gccttgctgc tgctgctgct cctgctgcta ttgtacaagt ataagcagaa 1920
gcccaagtac caggtccgct ggaagatcat cgagagctat gagggcaaca gttatacttt 1980
catcgacccc acgcagctgc cttacaacga gaagtgggag ttcccccgga acaacctgca 2040
gtttggtaag accctcggag ctggagcctt tgggaaggtg gtggaggcca cggcctttgg 2100
tctgggcaag gaggatgctg tcctgaaggt ggctgtgaag atgctgaagt ccacggccca 2160
tgctgatgag aaggaggccc tcatgtccga gctgaagatc atgagccacc tgggccagca 2220
cgagaacatc gtcaaccttc tgggagcctg tacccatgga ggccctgtac tggtcatcac 2280
ggagtactgt tgctatggcg acctgctcaa ctttctgcga aggaaggctg aggccatgct 2340
gggacccagc ctgagccccg gccaggaccc cgagggaggc gtcgactata agaacatcca 2400
cctcgagaag aaatatgtcc gcagggacag tggcttctcc agccagggtg tggacaccta 2460
tgtggagatg aggcctgtct ccacttcttc aaatgactcc ttctctgagc aagacctgga 2520
caaggaggat ggacggcccc tggagctccg ggacctgctt cacttctcca gccaagtagc 2580
ccagggcatg gccttcctcg cttccaagaa ttgcatccac cgggacgtgg cagcgcgtaa 2640
cgtgctgttg accaatggtc atgtggccaa gattggggac ttcgggctgg ctagggacat 2700
catgaatgac tccaactaca ttgtcaaggg caatgcccgc ctgcctgtga agtggatggc 2760
cccagagagc atctttgact gtgtctacac ggttcagagc gacgtctggt cctatggcat 2820
cctcctctgg gagatcttct cacttgggct gaatccctac cctggcatcc tggtgaacag 2880
caagttctat aaactggtga aggatggata ccaaatggcc cagcctgcat ttgccccaaa 2940
gaatatatac agcatcatgc aggcctgctg ggccttggag cccacccaca gacccacctt 3000
ccagcagatc tgctccttcc ttcaggagca ggcccaagag gacaggagag agcgggacta 3060
taccaatctg ccgagcagca gcagaagcgg tggcagcggc agcagcagca gtgagctgga 3120
ggaggagagc tctagtgagc acctgacctg ctgcgagcaa ggggatatcg cccagccctt 3180
gctgcagccc aacaactatc agttctgctg aggagttgac gacagggagt accactctcc 3240
cctcctccaa acttcaactc ctccatggat ggggcgacac ggggagaaca tacaaactct 3300
gccttcggtc atttcactca acagctcggc ccagctctga aacttgggaa ggtgagggat 3360
tcaggggagg tcagaggatc ccacttcctg agcatgggcc atcactgcca gtcaggggct 3420
gggggctgag ccctcacccc cccctcccct actgttctca tggtgttggc ctcgtgtttg 3480
ctatgccaac tagtagaacc ttctttccta atccccttat cttcatggaa atggactgac 3540
tttatgccta tgaagtcccc aggagctaca ctgatactga gaaaaccagg ctctttgggg 3600
ctagacagac tggcagagag tgagatctcc ctctctgaga ggagcagcag atgctcacag 3660
accacactca gctcaggccc cttggagcag gatggctcct ctaagaatct cacaggacct 3720
cttagtctct gccctatacg ccgccttcac tccacagcct cacccctccc acccccatac 3780
tggtactgct gtaatgagcc aagtggcagc taaaagttgg gggtgttctg cccagtcccg 3840
tcattctggg ctagaaggca ggggaccttg gcatgtggct ggccacacca agcaggaagc 3900
acaaactccc ccaagctgac tcatcctaac taacagtcac gccgtgggat gtctctgtcc 3960
acattaaact aacagcatta atgca                                       3985

<210> 380
<211> 5084
<212> DNA
<213> Homo Sapiens

<300> 
<308> GenBank No. NM_00022
<309> 2003-12-20  

<400> 380
gatcccatcg cagctaccgc gatgagaggc gctcgcggcg cctgggattt tctctgcgtt 60
ctgctcctac tgcttcgcgt ccagacaggc tcttctcaac catctgtgag tccaggggaa 120
ccgtctccac catccatcca tccaggaaaa tcagacttaa tagtccgcgt gggcgacgag 180
attaggctgt tatgcactga tccgggcttt gtcaaatgga cttttgagat cctggatgaa 240
acgaatgaga ataagcagaa tgaatggatc acggaaaagg cagaagccac caacaccggc 300
aaatacacgt gcaccaacaa acacggctta agcaattcca tttatgtgtt tgttagagat 360
cctgccaagc ttttccttgt tgaccgctcc ttgtatggga aagaagacaa cgacacgctg 420
gtccgctgtc ctctcacaga cccagaagtg accaattatt ccctcaaggg gtgccagggg 480
aagcctcttc ccaaggactt gaggtttatt cctgacccca aggcgggcat catgatcaaa 540
agtgtgaaac gcgcctacca tcggctctgt ctgcattgtt ctgtggacca ggagggcaag 600
tcagtgctgt cggaaaaatt catcctgaaa gtgaggccag ccttcaaagc tgtgcctgtt 660
gtgtctgtgt ccaaagcaag ctatcttctt agggaagggg aagaattcac agtgacgtgc 720
acaataaaag atgtgtctag ttctgtgtac tcaacgtgga aaagagaaaa cagtcagact 780
aaactacagg agaaatataa tagctggcat cacggtgact tcaattatga acgtcaggca 840
acgttgacta tcagttcagc gagagttaat gattctggag tgttcatgtg ttatgccaat 900
aatacttttg gatcagcaaa tgtcacaaca accttggaag tagtagataa aggattcatt 960
aatatcttcc ccatgataaa cactacagta tttgtaaacg atggagaaaa tgtagatttg 1020
attgttgaat atgaagcatt ccccaaacct gaacaccagc agtggatcta tatgaacaga 1080
accttcactg ataaatggga agattatccc aagtctgaga atgaaagtaa tatcagatac 1140
gtaagtgaac ttcatctaac gagattaaaa ggcaccgaag gaggcactta cacattccta 1200
gtgtccaatt ctgacgtcaa tgctgccata gcatttaatg tttatgtgaa tacaaaacca 1260
gaaatcctga cttacgacag gctcgtgaat ggcatgctcc aatgtgtggc agcaggattc 1320
ccagagccca caatagattg gtatttttgt ccaggaactg agcagagatg ctctgcttct 1380
gtactgccag tggatgtgca gacactaaac tcatctgggc caccgtttgg aaagctagtg 1440
gttcagagtt ctatagattc tagtgcattc aagcacaatg gcacggttga atgtaaggct 1500
tacaacgatg tgggcaagac ttctgcctat tttaactttg catttaaagg taacaacaaa 1560
gagcaaatcc atccccacac cctgttcact cctttgctga ttggtttcgt aatcgtagct 1620
ggcatgatgt gcattattgt gatgattctg acctacaaat atttacagaa acccatgtat 1680
gaagtacagt ggaaggttgt tgaggagata aatggaaaca attatgttta catagaccca 1740
acacaacttc cttatgatca caaatgggag tttcccagaa acaggctgag ttttgggaaa 1800
accctgggtg ctggagcttt cgggaaggtt gttgaggcaa ctgcttatgg cttaattaag 1860
tcagatgcgg ccatgactgt cgctgtaaag atgctcaagc cgagtgccca tttgacagaa 1920
cgggaagccc tcatgtctga actcaaagtc ctgagttacc ttggtaatca catgaatatt 1980
gtgaatctac ttggagcctg caccattgga gggcccaccc tggtcattac agaatattgt 2040
tgctatggtg atcttttgaa ttttttgaga agaaaacgtg attcatttat ttgttcaaag 2100
caggaagatc atgcagaagc tgcactttat aagaatcttc tgcattcaaa ggagtcttcc 2160
tgcagcgata gtactaatga gtacatggac atgaaacctg gagtttctta tgttgtccca 2220
accaaggccg acaaaaggag atctgtgaga ataggctcat acatagaaag agatgtgact 2280
cccgccatca tggaggatga cgagttggcc ctagacttag aagacttgct gagcttttct 2340
taccaggtgg caaagggcat ggctttcctc gcctccaaga attgtattca cagagacttg 2400
gcagccagaa atatcctcct tactcatggt cggatcacaa agatttgtga ttttggtcta 2460
gccagagaca tcaagaatga ttctaattat gtggttaaag gaaacgctcg actacctgtg 2520
aagtggatgg cacctgaaag cattttcaac tgtgtataca cgtttgaaag tgacgtctgg 2580
tcctatggga tttttctttg ggagctgttc tctttaggaa gcagccccta tcctggaatg 2640
ccggtcgatt ctaagttcta caagatgatc aaggaaggct tccggatgct cagccctgaa 2700
cacgcacctg ctgaaatgta tgacataatg aagacttgct gggatgcaga tcccctaaaa 2760
agaccaacat tcaagcaaat tgttcagcta attgagaagc agatttcaga gagcaccaat 2820
catatttact ccaacttagc aaactgcagc cccaaccgac agaagcccgt ggtagaccat 2880
tctgtgcgga tcaattctgt cggcagcacc gcttcctcct cccagcctct gcttgtgcac 2940
gacgatgtct gagcagaatc agtgtttggg tcacccctcc aggaatgatc tcttcttttg 3000
gcttccatga tggttatttt cttttctttc aacttgcatc caactccagg atagtgggca 3060
ccccactgca atcctgtctt tctgagcaca ctttagtggc cgatgatttt tgtcatcagc 3120
caccatccta ttgcaaaggt tccaactgta tatattccca atagcaacgt agcttctacc 3180
atgaacagaa aacattctga tttggaaaaa gagagggagg tatggactgg gggccagagt 3240
cctttccaag gcttctccaa ttctgcccaa aaatatggtt gatagtttac ctgaataaat 3300
ggtagtaatc acagttggcc ttcagaacca tccatagtag tatgatgata caagattaga 3360
agctgaaaac ctaagtcctt tatgtggaaa acagaacatc attagaacaa aggacagagt 3420
atgaacacct gggcttaaga aatctagtat ttcatgctgg gaatgagaca taggccatga 3480
aaaaaatgat ccccaagtgt gaacaaaaga tgctcttctg tggaccactg catgagcttt 3540
tatactaccg acctggtttt taaatagagt ttgctattag agcattgaat tggagagaag 3600
gcctccctag ccagcacttg tatatacgca tctataaatt gtccgtgttc atacatttga 3660
ggggaaaaca ccataaggtt tcgtttctgt atacaaccct ggcattatgt ccactgtgta 3720
tagaagtaga ttaagagcca tataagtttg aaggaaacag ttaataccat tttttaagga 3780
aacaatataa ccacaaagca cagtttgaac aaaatctcct cttttagctg atgaacttat 3840
tctgtagatt ctgtggaaca agcctatcag cttcagaatg gcattgtact caatggattt 3900
gatgctgttt gacaaagtta ctgattcact gcatggctcc cacaggagtg ggaaaacact 3960
gccatcttag tttggattct tatgtagcag gaaataaagt ataggtttag cctccttcgc 4020
aggcatgtcc tggacaccgg gccagtatct atatatgtgt atgtacgttt gtatgtgtgt 4080
agacaaatat ttggaggggt atttttgccc tgagtccaag agggtccttt agtacctgaa 4140
aagtaacttg gctttcatta ttagtactgc tcttgtttct tttcacatag ctgtctagag 4200
tagcttacca gaagcttcca tagtggtgca gaggaagtgg aaggcatcag tccctatgta 4260
tttgcagttc acctgcactt aaggcactct gttatttaga ctcatcttac tgtacctgtt 4320
ccttagacct tccataatgc tactgtctca ctgaaacatt taaattttac cctttagact 4380
gtagcctgga tattattctt gtagtttacc tctttaaaaa caaaacaaaa caaaacaaaa 4440
aactcccctt cctcactgcc caatataaaa ggcaaatgtg tacatggcag agtttgtgtg 4500
ttgtcttgaa agattcaggt atgttgcctt tatggtttcc cccttctaca tttcttagac 4560
tacatttaga gaactgtggc cgttatctgg aagtaaccat ttgcactgga gttctatgct 4620
ctcgcacctt tccaaagtta acagattttg gggttgtgtt gtcacccaag agattgttgt 4680
ttgccatact ttgtctgaaa aattcctttg tgtttctatt gacttcaatg atagtaagaa 4740
aagtggttgt tagttataga tgtctaggta cttcaggggc acttcattga gagttttgtc 4800
ttgccatact ttgtctgaaa aattcctttg tgtttctatt gacttcaatg atagtaagaa 4860
aagtggttgt tagttataga tgtctaggta cttcaggggc acttcattga gagttttgtc 4920
aatgtctttt gaatattccc aagcccatga gtccttgaaa atatttttta tatatacagt 4980
aactttatgt gtaaatacat aagcggcgta agtttaaagg atgttggtgt tccacgtgtt 5040
ttattcctgt atgttgtcca attgttgaca gttctgaaga attc                  5084

<210> 381
<211> 3475
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM004119
<309> 2005-01-22  

<400> 381
cgaggcggca tccgagggct gggccggcgc cctgggggac cccgggctcc ggaggccatg 60
ccggcgttgg cgcgcgacgc gggcaccgtg ccgctgctcg ttgttttttc tgcaatgata 120
tttgggacta ttacaaatca agatctgcct gtgatcaagt gtgttttaat caatcataag 180
aacaatgatt catcagtggg gaagtcatca tcatatccca tggtatcaga atccccggaa 240
gacctcgggt gtgcgttgag accccagagc tcagggacag tgtacgaagc tgccgctgtg 300
gaagtggatg tatctgcttc catcacactg caagtgctgg tcgatgcccc agggaacatt 360
tcctgtctct gggtctttaa gcacagctcc ctgaattgcc agccacattt tgatttacaa 420
aacagaggag ttgtttccat ggtcattttg aaaatgacag aaacccaagc tggagaatac 480
ctacttttta ttcagagtga agctaccaat tacacaatat tgtttacagt gagtataaga 540
aataccctgc tttacacatt aagaagacct tactttagaa aaatggaaaa ccaggacgcc 600
ctggtctgca tatctgagag cgttccagag ccgatcgtgg aatgggtgct ttgcgattca 660
cagggggaaa gctgtaaaga agaaagtcca gctgttgtta aaaaggagga aaaagtgctt 720
catgaattat ttgggacgga cataaggtgc tgtgccagaa atgaactggg cagggaatgc 780
accaggctgt tcacaataga tctaaatcaa actcctcaga ccacattgcc acaattattt 840
cttaaagtag gggaaccctt atggataagg tgcaaagctg ttcatgtgaa ccatggattc 900
gggctcacct gggaattaga aaacaaagca ctcgaggagg gcaactactt tgagatgagt 960
acctattcaa caaacagaac tatgatacgg attctgtttg cttttgtatc atcagtggca 1020
agaaacgaca ccggatacta cacttgttcc tcttcaaagc atcccagtca atcagctttg 1080
gttaccatcg taggaaaggg atttataaat gctaccaatt caagtgaaga ttatgaaatt 1140
gaccaatatg aagagttttg tttttctgtc aggtttaaag cctacccaca aatcagatgt 1200
acgtggacct tctctcgaaa atcatttcct tgtgagcaaa agggtcttga taacggatac 1260
agcatatcca agttttgcaa tcataagcac cagccaggag aatatatatt ccatgcagaa 1320
aatgatgatg cccaatttac caaaatgttc acgctgaata taagaaggaa acctcaagtg 1380
ctcgcagaag catcggcaag tcaggcgtcc tgtttctcgg atggataccc attaccatct 1440
tggacctgga agaagtgttc agacaagtct cccaactgca cagaagagat cacagaagga 1500
gtctggaata gaaaggctaa cagaaaagtg tttggacagt gggtgtcgag cagtactcta 1560
aacatgagtg aagccataaa agggttcctg gtcaagtgct gtgcatacaa ttcccttggc 1620
acatcttgtg agacgatcct tttaaactct ccaggcccct tccctttcat ccaagacaac 1680
atctcattct atgcaacaat tggtgtttgt ctcctcttca ttgtcgtttt aaccctgcta 1740
atttgtcaca agtacaaaaa gcaatttagg tatgaaagcc agctacagat ggtacaggtg 1800
accggctcct cagataatga gtacttctac gttgatttca gagaatatga atatgatctc 1860
aaatgggagt ttccaagaga aaatttagag tttgggaagg tactaggatc aggtgctttt 1920
ggaaaagtga tgaacgcaac agcttatgga attagcaaaa caggagtctc aatccaggtt 1980
gccgtcaaaa tgctgaaaga aaaagcagac agctctgaaa gagaggcact catgtcagaa 2040
ctcaagatga tgacccagct gggaagccac gagaatattg tgaacctgct gggggcgtgc 2100
acactgtcag gaccaattta cttgattttt gaatactgtt gctatggtga tcttctcaac 2160
tatctaagaa gtaaaagaga aaaatttcac aggacttgga cagagatttt caaggaacac 2220
aatttcagtt tttaccccac tttccaatca catccaaatt ccagcatgcc tggttcaaga 2280
gaagttcaga tacacccgga ctcggatcaa atctcagggc ttcatgggaa ttcatttcac 2340
tctgaagatg aaattgaata tgaaaaccaa aaaaggctgg aagaagagga ggacttgaat 2400
gtgcttacat ttgaagatct tctttgcttt gcatatcaag ttgccaaagg aatggaattt 2460
ctggaattta agtcgtgtgt tcacagagac ctggccgcca ggaacgtgct tgtcacccac 2520
gggaaagtgg tgaagatatg tgactttgga ttggctcgag atatcatgag tgattccaac 2580
tatgttgtca ggggcaatgc ccgtctgcct gtaaaatgga tggcccccga aagcctgttt 2640
gaaggcatct acaccattaa gagtgatgtc tggtcatatg gaatattact gtgggaaatc 2700
ttctcacttg gtgtgaatcc ttaccctggc attccggttg atgctaactt ctacaaactg 2760
attcaaaatg gatttaaaat ggatcagcca ttttatgcta cagaagaaat atacattata 2820
atgcaatcct gctgggcttt tgactcaagg aaacggccat ccttccctaa tttgacttcg 2880
tttttaggat gtcagctggc agatgcagaa gaagcgatgt atcagaatgt ggatggccgt 2940
gtttcggaat gtcctcacac ctaccaaaac aggcgacctt tcagcagaga gatggatttg 3000
gggctactct ctccgcaggc tcaggtcgaa gattcgtaga ggaacaattt agttttaagg 3060
acttcatccc tccacctatc cctaacaggc tgtagattac caaaacaaga ttaatttcat 3120
cactaaaaga aaatctatta tcaactgctg cttcaccaga cttttctcta gaagccgtct 3180
gcgtttactc ttgttttcaa agggactttt gtaaaatcaa atcatcctgt cacaaggcag 3240
gaggagctga taatgaactt tattggagca ttgatctgca tccaaggcct tctcaggccg 3300
gcttgagtga attgtgtacc tgaagtacag tatattcttg taaatacata aaacaaaagc 3360
attttgctaa ggagaagcta atatgatttt ttaagtctat gttttaaaat aatatgtaaa 3420
tttttcagct atttagtgat atattttatg ggtgggaata aaatttctac tacag      3475

<210> 382
<211> 6633
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM006206
<309> 2004-10-26  

<400> 382
ttctccccgc cccccagttg ttgtcgaagt ctgggggttg ggactggacc ccctgattgc 60
gtaagagcaa aaagcgaagg cgcaatctgg acactgggag attcggagcg cagggagttt 120
gagagaaact tttattttga agagaccaag gttgaggggg ggcttatttc ctgacagcta 180
tttacttaga gcaaatgatt agttttagaa ggatggacta taacattgaa tcaattacaa 240
aacgcggttt ttgagcccat tactgttgga gctacaggga gagaaacagg aggagactgc 300
aagagatcat ttgggaaggc cgtgggcacg ctctttactc catgtgtggg acattcattg 360
cggaataaca tcggaggaga agtttcccag agctatgggg acttcccatc cggcgttcct 420
ggtcttaggc tgtcttctca cagggctgag cctaatcctc tgccagcttt cattaccctc 480
tatccttcca aatgaaaatg aaaaggttgt gcagctgaat tcatcctttt ctctgagatg 540
ctttggggag agtgaagtga gctggcagta ccccatgtct gaagaagaga gctccgatgt 600
ggaaatcaga aatgaagaaa acaacagcgg cctttttgtg acggtcttgg aagtgagcag 660
tgcctcggcg gcccacacag ggttgtacac ttgctattac aaccacactc agacagaaga 720
gaatgagctt gaaggcaggc acatttacat ctatgtgcca gacccagatg tagcctttgt 780
acctctagga atgacggatt atttagtcat cgtggaggat gatgattctg ccattatacc 840
ttgtcgcaca actgatcccg agactcctgt aaccttacac aacagtgagg gggtggtacc 900
tgcctcctac gacagcagac agggctttaa tgggaccttc actgtagggc cctatatctg 960
tgaggccacc gtcaaaggaa agaagttcca gaccatccca tttaatgttt atgctttaaa 1020
agcaacatca gagctggatc tagaaatgga agctcttaaa accgtgtata agtcagggga 1080
aacgattgtg gtcacctgtg ctgtttttaa caatgaggtg gttgaccttc aatggactta 1140
ccctggagaa gtgaaaggca aaggcatcac aatgctggaa gaaatcaaag tcccatccat 1200
caaattggtg tacactttga cggtccccga ggccacggtg aaagacagtg gagattacga 1260
atgtgctgcc cgccaggcta ccagggaggt caaagaaatg aagaaagtca ctatttctgt 1320
ccatgagaaa ggtttcattg aaatcaaacc caccttcagc cagttggaag ctgtcaacct 1380
gcatgaagtc aaacattttg ttgtagaggt gcgggcctac ccacctccca ggatatcctg 1440
gctgaaaaac aatctgactc tgattgaaaa tctcactgag atcaccactg atgtggaaaa 1500
gattcaggaa ataaggtatc gaagcaaatt aaagctgatc cgtgctaagg aagaagacag 1560
tggccattat actattgtag ctcaaaatga agatgctgtg aagagctata cttttgaact 1620
gttaactcaa gttccttcat ccattctgga cttggtcgat gatcaccatg gctcaactgg 1680
gggacagacg gtgaggtgca cagctgaagg cacgccgctt cctgatattg agtggatgat 1740
atgcaaagat attaagaaat gtaataatga aacttcctgg actattttgg ccaacaatgt 1800
ctcaaacatc atcacggaga tccactcccg agacaggagt accgtggagg gccgtgtgac 1860
tttcgccaaa gtggaggaga ccatcgccgt gcgatgcctg gctaagaatc tccttggagc 1920
tgagaaccga gagctgaagc tggtggctcc caccctgcgt tctgaactca cggtggctgc 1980
tgcagtcctg gtgctgttgg tgattgtgat catctcactt attgtcctgg ttgtcatttg 2040
gaaacagaaa ccgaggtatg aaattcgctg gagggtcatt gaatcaatca gcccggatgg 2100
acatgaatat atttatgtgg acccgatgca gctgccttat gactcaagat gggagtttcc 2160
aagagatgga ctagtgcttg gtcgggtctt ggggtctgga gcgtttggga aggtggttga 2220
aggaacagcc tatggattaa gccggtccca acctgtcatg aaagttgcag tgaagatgct 2280
aaaacccacg gccagatcca gtgaaaaaca agctctcatg tctgaactga agataatgac 2340
tcacctgggg ccacatttga acattgtaaa cttgctggga gcctgcacca agtcaggccc 2400
catttacatc atcacagagt attgcttcta tggagatttg gtcaactatt tgcataagaa 2460
tagggatagc ttcctgagcc accacccaga gaagccaaag aaagagctgg atatctttgg 2520
attgaaccct gctgatgaaa gcacacggag ctatgttatt ttatcttttg aaaacaatgg 2580
tgactacatg gacatgaagc aggctgatac tacacagtat gtccccatgc tagaaaggaa 2640
agaggtttct aaatattccg acatccagag atcactctat gatcgtccag cctcatataa 2700
gaagaaatct atgttagact cagaagtcaa aaacctcctt tcagatgata actcagaagg 2760
ccttacttta ttggatttgt tgagcttcac ctatcaagtt gcccgaggaa tggagttttt 2820
ggcttcaaaa aattgtgtcc accgtgatct ggctgctcgc aacgtcctcc tggcacaagg 2880
aaaaattgtg aagatctgtg actttggcct ggccagagac atcatgcatg attcgaacta 2940
tgtgtcgaaa ggcagtacct ttctgcccgt gaagtggatg gctcctgaga gcatctttga 3000
caacctctac accacactga gtgatgtctg gtcttatggc attctgctct gggagatctt 3060
ttcccttggt ggcacccctt accccggcat gatggtggat tctactttct acaataagat 3120
caagagtggg taccggatgg ccaagcctga ccacgctacc agtgaagtct acgagatcat 3180
ggtgaaatgc tggaacagtg agccggagaa gagaccctcc ttttaccacc tgagtgagat 3240
tgtggagaat ctgctgcctg gacaatataa aaagagttat gaaaaaattc acctggactt 3300
cctgaagagt gaccatcctg ctgtggcacg catgcgtgtg gactcagaca atgcatacat 3360
tggtgtcacc tacaaaaacg aggaagacaa gctgaaggac tgggagggtg gtctggatga 3420
gcagagactg agcgctgaca gtggctacat cattcctctg cctgacattg accctgtccc 3480
tgaggaggag gacctgggca agaggaacag acacagctcg cagacctctg aagagagtgc 3540
cattgagacg ggttccagca gttccacctt catcaagaga gaggacgaga ccattgaaga 3600
catcgacatg atggacgaca tcggcataga ctcttcagac ctggtggaag acagcttcct 3660
gtaactggcg gattcgaggg gttccttcca cttctggggc cacctctgga tcccgttcag 3720
aaaaccactt tattgcaatg cggaggttga gaggaggact tggttgatgt ttaaagagaa 3780
gttcccagcc aagggcctcg gggagcgttc taaatatgaa tgaatgggat attttgaaat 3840
gaactttgtc agtgttgcct ctcgcaatgc ctcagtagca tctcagtggt gtgtgaagtt 3900
tggagataga tggataaggg aataataggc cacagaaggt gaactttgtg cttcaaggac 3960
attggtgaga gtccaacaga cacaatttat actgcgacag aacttcagca ttgtaattat 4020
gtaaataact ctaaccaagg ctgtgtttag attgtattaa ctatcttctt tggacttctg 4080
aagagaccac tcaatccatc catgtacttc cctcttgaaa cctgatgtca gctgctgttg 4140
aactttttaa agaagtgcat gaaaaaccat ttttgaacct taaaaggtac tggtactata 4200
gcattttgct atctttttta gtgttaagag ataaagaata ataattaacc aaccttgttt 4260
aatagatttg ggtcatttag aagcctgaca actcattttc atattgtaat ctatgtttat 4320
aatactacta ctgttatcag taatgctaaa tgtgtaataa tgtaacatga tttccctcca 4380
gagaaagcac aatttaaaac aatccttact aagtaggtga tgagtttgac agtttttgac 4440
atttatatta aataacatgt ttctctataa agtatggtaa tagctttagt gaattaaatt 4500
tagttgagca tagagaacaa agtaaaagta gtgttgtcca ggaagtcaga atttttaact 4560
gtactgaata ggttccccaa tccatcgtat taaaaaacaa ttaactgccc tctgaaataa 4620
tgggattaga aacaaacaaa actcttaagt cctaaaagtt ctcaatgtag aggcataaac 4680
ctgtgctgaa cataacttct catgtatatt acccaatgga aaatataatg atcagcaaaa 4740
agactggatt tgcagaagtt tttttttttt ttcttcatgc ctgatgaaag ctttggcaac 4800
cccaatatat gtattttttg aatctatgaa cctgaaaagg gtcagaagga tgcccagaca 4860
tcagcctcct tctttcaccc cttaccccaa agagaaagag tttgaaactc gagaccataa 4920
agatattctt tagtggaggc tggatgtgca ttagcctgga tcctcagttc tcaaatgtgt 4980
gtggcagcca ggatgactag atcctgggtt tccatccttg agattctgaa gtatgaagtc 5040
tgagggaaac cagagtctgt atttttctaa actccctggc tgttctgatc ggccagtttt 5100
cggaaacact gacttaggtt tcaggaagtt gccatgggaa acaaataatt tgaactttgg 5160
aacagggttg gaattcaacc acgcaggaag cctactattt aaatccttgg cttcaggtta 5220
gtgacattta atgccatcta gctagcaatt gcgaccttaa tttaactttc cagtcttagc 5280
tgaggctgag aaagctaaag tttggttttg acaggttttc caaaagtaaa gatgctactt 5340
cccactgtat gggggagatt gaactttccc cgtctcccgt cttctgcctc ccactccata 5400
ccccgccaag gaaaggcatg tacaaaaatt atgcaattca gtgttccaag tctctgtgta 5460
accagctcag tgttttggtg gaaaaaacat tttaagtttt actgataatt tgaggttaga 5520
tgggaggatg aattgtcaca tctatccaca ctgtcaaaca ggttggtgtg ggttcattgg 5580
cattctttgc aatactgctt aattgctgat accatatgaa tgaaacatgg gctgtgatta 5640
ctgcaatcac tgtgctatcg gcagatgatg ctttggaaga tgcagaagca ataataaagt 5700
acttgactac ctactggtgt aatctcaatg caagccccaa ctttcttatc caactttttc 5760
atagtaagtg cgaagactga gccagattgg ccaattaaaa acgaaaacct gactaggttc 5820
tgtagagcca attagacttg aaatacgttt gtgtttctag aatcacagct caagcattct 5880
gtttatcgct cactctccct tgtacagcct tattttgttg gtgctttgca ttttgatatt 5940
gctgtgagcc ttgcatgaca tcatgaggcc ggatgaaact tctcagtcca gcagtttcca 6000
gtcctaacaa atgctcccac ctgaatttgt atatgactgc atttgtgggt gtgtgtgtgt 6060
tttcagcaaa ttccagattt gtttcctttt ggcctcctgc aaagtctcca gaagaaaatt 6120
tgccaatctt tcctactttc tatttttatg atgacaatca aagccggcct gagaaacact 6180
atttgtgact ttttaaacga ttagtgatgt ccttaaaatg tggtctgcca atctgtacaa 6240
aatggtccta tttttgtgaa gagggacata agataaaatg atgttataca tcaatatgta 6300
tatatgtatt tctatataga cttggagaat actgccaaaa catttatgac aagctgtatc 6360
actgccttcg tttatatttt tttaactgtg ataatcccca caggcacatt aactgttgca 6420
cttttgaatg tccaaaattt atattttaga aataataaaa agaaagatac ttacatgttc 6480
ccaaaacaat ggtgtggtga atgtgtgaga aaaactaact tgatagggtc taccaataca 6540
aaatgtatta cgaatgcccc tgttcatgtt tttgttttaa aacgtgtaaa tgaagatctt 6600
tatatttcaa taaatgatat ataatttaaa gtt                              6633

<210> 383
<211> 5598
<212> DNA
<213> Homo Sapiens

<300> 
<308> GenBank No. NM002609
<309> 2004-10-26  

<400> 383
ggcccctcag ccctgctgcc cagcacgagc ctgtgctcgc cctgcccaac gcagacagcc 60
agacccaggg cggcccctct ggcggctctg ctcctcccga aggatgcttg gggagtgagg 120
cgaagctggg cgctcctctc ccctacagca gcccccttcc tccatccctc tgttctcctg 180
agccttcagg agcctgcacc agtcctgcct gtccttctac tcagctgtta cccactctgg 240
gaccagcagt ctttctgata actgggagag ggcagtaagg aggacttcct ggagggggtg 300
actgtccaga gcctggaact gtgcccacac cagaagccat cagcagcaag gacaccatgc 360
ggcttccggg tgcgatgcca gctctggccc tcaaaggcga gctgctgttg ctgtctctcc 420
tgttacttct ggaaccacag atctctcagg gcctggtcgt cacacccccg gggccagagc 480
ttgtcctcaa tgtctccagc accttcgttc tgacctgctc gggttcagct ccggtggtgt 540
gggaacggat gtcccaggag cccccacagg aaatggccaa ggcccaggat ggcaccttct 600
ccagcgtgct cacactgacc aacctcactg ggctagacac gggagaatac ttttgcaccc 660
acaatgactc ccgtggactg gagaccgatg agcggaaacg gctctacatc tttgtgccag 720
atcccaccgt gggcttcctc cctaatgatg ccgaggaact attcatcttt ctcacggaaa 780
taactgagat caccattcca tgccgagtaa cagacccaca gctggtggtg acactgcacg 840
agaagaaagg ggacgttgca ctgcctgtcc cctatgatca ccaacgtggc ttttctggta 900
tctttgagga cagaagctac atctgcaaaa ccaccattgg ggacagggag gtggattctg 960
atgcctacta tgtctacaga ctccaggtgt catccatcaa cgtctctgtg aacgcagtgc 1020
agactgtggt ccgccagggt gagaacatca ccctcatgtg cattgtgatc gggaatgagg 1080
tggtcaactt cgagtggaca tacccccgca aagaaagtgg gcggctggtg gagccggtga 1140
ctgacttcct cttggatatg ccttaccaca tccgctccat cctgcacatc cccagtgccg 1200
agttagaaga ctcggggacc tacacctgca atgtgacgga gagtgtgaat gaccatcagg 1260
atgaaaaggc catcaacatc accgtggttg agagcggcta cgtgcggctc ctgggagagg 1320
tgggcacact acaatttgct gagctgcatc ggagccggac actgcaggta gtgttcgagg 1380
cctacccacc gcccactgtc ctgtggttca aagacaaccg caccctgggc gactccagcg 1440
ctggcgaaat cgccctgtcc acgcgcaacg tgtcggagac ccggtatgtg tcagagctga 1500
cactggttcg cgtgaaggtg gcagaggctg gccactacac catgcgggcc ttccatgagg 1560
atgctgaggt ccagctctcc ttccagctac agatcaatgt ccctgtccga gtgctggagc 1620
taagtgagag ccaccctgac agtggggaac agacagtccg ctgtcgtggc cggggcatgc 1680
cccagccgaa catcatctgg tctgcctgca gagacctcaa aaggtgtcca cgtgagctgc 1740
cgcccacgct gctggggaac agttccgaag aggagagcca gctggagact aacgtgacgt 1800
actgggagga ggagcaggag tttgaggtgg tgagcacact gcgtctgcag cacgtggatc 1860
ggccactgtc ggtgcgctgc acgctgcgca acgctgtggg ccaggacacg caggaggtca 1920
tcgtggtgcc acactccttg ccctttaagg tggtggtgat ctcagccatc ctggccctgg 1980
tggtgctcac catcatctcc cttatcatcc tcatcatgct ttggcagaag aagccacgtt 2040
acgagatccg atggaaggtg attgagtctg tgagctctga cggccatgag tacatctacg 2100
tggaccccat gcagctgccc tatgactcca cgtgggagct gccgcgggac cagcttgtgc 2160
tgggacgcac cctcggctct ggggcctttg ggcaggtggt ggaggccacg gctcatggcc 2220
tgagccattc tcaggccacg atgaaagtgg ccgtcaagat gcttaaatcc acagcccgca 2280
gcagtgagaa gcaagccctt atgtcggagc tgaagatcat gagtcacctt gggccccacc 2340
tgaacgtggt caacctgttg ggggcctgca ccaaaggagg acccatctat atcatcactg 2400
agtactgccg ctacggagac ctggtggact acctgcaccg caacaaacac accttcctgc 2460
agcaccactc cgacaagcgc cgcccgccca gcgcggagct ctacagcaat gctctgcccg 2520
ttgggctccc cctgcccagc catgtgtcct tgaccgggga gagcgacggt ggctacatgg 2580
acatgagcaa ggacgagtcg gtggactatg tgcccatgct ggacatgaaa ggagacgtca 2640
aatatgcaga catcgagtcc tccaactaca tggcccctta cgataactac gttccctctg 2700
cccctgagag gacctgccga gcaactttga tcaacgagtc tccagtgcta agctacatgg 2760
acctcgtggg cttcagctac caggtggcca atggcatgga gtttctggcc tccaagaact 2820
gcgtccacag agacctggcg gctaggaacg tgctcatctg tgaaggcaag ctggtcaaga 2880
tctgtgactt tggcctggct cgagacatca tgcgggactc gaattacatc tccaaaggca 2940
gcaccttttt gcctttaaag tggatggctc cggagagcat cttcaacagc ctctacacca 3000
ccctgagcga cgtgtggtcc ttcgggatcc tgctctggga gatcttcacc ttgggtggca 3060
ccccttaccc agagctgccc atgaacgagc agttctacaa tgccatcaaa cggggttacc 3120
gcatggccca gcctgcccat gcctccgacg agatctatga gatcatgcag aagtgctggg 3180
aagagaagtt tgagattcgg ccccccttct cccagctggt gctgcttctc gagagactgt 3240
tgggcgaagg ttacaaaaag aagtaccagc aggtggatga ggagtttctg aggagtgacc 3300
acccagccat ccttcggtcc caggcccgct tgcctgggtt ccatggcctc cgatctcccc 3360
tggacaccag ctccgtcctc tatactgccg tgcagcccaa tgagggtgac aacgactata 3420
tcatccccct gcctgacccc aaacccgagg ttgctgacga gggcccactg gagggttccc 3480
ccagcctagc cagctccacc ctgaatgaag tcaacacctc ctcaaccatc tcctgtgaca 3540
gccccctgga gccccaggac gaaccagagc cagagcccca gcttgagctc caggtggagc 3600
cggagccaga gctggaacag ttgccggatt cggggtgccc tgcgcctcgg gcggaagcag 3660
aggatagctt cctgtagggg gctggcccct accctgccct gcctgaagct ccccccctgc 3720
cagcacccag catctcctgg cctggcctga ccgggcttcc tgtcagccag gctgccctta 3780
tcagctgtcc ccttctggaa gctttctgct cctgacgtgt tgtgccccaa accctggggc 3840
tggcttagga ggcaagaaaa ctgcaggggc cgtgaccagc cctctgcctc cagggaggcc 3900
aactgactct gagccagggt tcccccaggg aactcagttt tcccatatgt aagatgggaa 3960
agttaggctt gatgacccag aatctaggat tctctccctg gctgacaggt ggggagaccg 4020
aatccctccc tgggaagatt cttggagtta ctgaggtggt aaattaactt ttttctgttc 4080
agccagctac ccctcaagga atcatagctc tctcctcgca ctttttatcc acccaggagc 4140
tagggaagag accctagcct ccctggctgc tggctgagct agggcctagc cttgagcagt 4200
gttgcctcat ccagaagaaa gccagtctcc tccctatgat gccagtccct gcgttccctg 4260
gcccgagctg gtctggggcc attaggcagc ctaattaatg ctggaggctg agccaagtac 4320
aggacacccc cagcctgcag cccttgccca gggcacttgg agcacacgca gccatagcaa 4380
gtgcctgtgt ccctgtcctt caggcccatc agtcctgggg ctttttcttt atcaccctca 4440
gtcttaatcc atccaccaga gtctagaagg ccagacgggc cccgcatctg tgatgagaat 4500
gtaaatgtgc cagtgtggag tggccacgtg tgtgtgccag tatatggccc tggctctgca 4560
ttggacctgc tatgaggctt tggaggaatc cctcaccctc tctgggcctc agtttcccct 4620
tcaaaaaatg aataagtcgg acttattaac tctgagtgcc ttgccagcac taacattcta 4680
gagtattcca ggtggttgca catttgtcca gatgaagcaa ggccatatac cctaaacttc 4740
catcctgggg gtcagctggg ctcctgggag attccagatc acacatcaca ctctggggac 4800
tcaggaacca tgccccttcc ccaggccccc agcaagtctc aagaacacag ctgcacaggc 4860
cttgacttag agtgacagcc ggtgtcctgg aaagccccaa gcagctgccc cagggacatg 4920
ggaagaccac gggacctctt tcactaccca cgatgacctc cgggggtatc ctgggcaaaa 4980
gggacaaaga gggcaaatga gatcacctcc tgcagcccac cactccagca cctgtgccga 5040
ggtctgcgtc gaagacagaa tggacagtga ggacagttat gtcttgtaaa agacaagaag 5100
cttcagatgg taccccaaga aggatgtgag aggtggccgc ttggagtttg cccctcaccc 5160
accagctgcc ccatccctga ggcagcgctc catgggggta tggttttgtc actgcccaga 5220
cctagcagtg acatctcatt gtccccagcc cagtgggcat tggaggtgcc aggggagtca 5280
gggttgtagc caagacgccc ccgcacgggg agggttggga agggggtgca ggaagctcaa 5340
cccctctggg caccaaccct gcattgcagg ttggcacctt acttccctgg gatccccaga 5400
gttggtccaa ggagggagag tgggttctca atacggtacc aaagatataa tcacctaggt 5460
ttacaaatat ttttaggact cacgttaact cacatttata cagcagaaat gctattttgt 5520
atgctgttaa gtttttctat ctgtgtactt ttttttaagg gaaagatttt aatattaaac 5580
ctggtgcttc tcactcac                                               5598

<210> 384
<211> 1414
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM001136
<309> 2005-10-31

<400> 384
gccaggaccc tggaaggaag caggatggca gccggaacag cagttggagc ctgggtgctg 60
gtcctcagtc tgtggggggc agtagtaggt gctcaaaaca tcacagcccg gattggcgag 120
ccactggtgc tgaagtgtaa gggggccccc aagaaaccac cccagcggct ggaatggaaa 180
ctgaacacag gccggacaga agcttggaag gtcctgtctc cccagggagg aggcccctgg 240
gacagtgtgg ctcgtgtcct tcccaacggc tccctcttcc ttccggctgt cgggatccag 300
gatgagggga ttttccggtg ccaggcaatg aacaggaatg gaaaggagac caagtccaac 360
taccgagtcc gtgtctacca gattcctggg aagccagaaa ttgtagattc tgcctctgaa 420
ctcacggctg gtgttcccaa taaggtgggg acatgtgtgt cagagggaag ctaccctgca 480
gggactctta gctggcactt ggatgggaag cccctggtgc ctaatgagaa gggagtatct 540
gtgaaggaac agaccaggag acaccctgag acagggctct tcacactgca gtcggagcta 600
atggtgaccc cagcccgggg aggagatccc cgtcccacct tctcctgtag cttcagccca 660
ggccttcccc gacaccgggc cttgcgcaca gcccccatcc agccccgtgt ctgggagcct 720
gtgcctctgg aggaggtcca attggtggtg gagccagaag gtggagcagt agctcctggt 780
ggaaccgtaa ccctgacctg tgaagtccct gcccagccct ctcctcaaat ccactggatg 840
aaggatggtg tgcccttgcc ccttcccccc agccctgtgc tgatcctccc tgagataggg 900
cctcaggacc agggaaccta cagctgtgtg gccacccatt ccagccacgg gccccaggaa 960
agccgtgctg tcagcatcag catcatcgaa ccaggcgagg aggggccaac tgcaggctct 1020
gtgggaggat cagggctggg aactctagcc ctggccctgg ggatcctggg aggcctgggg 1080
acagccgccc tgctcattgg ggtcatcttg tggcaaaggc ggcaacgccg aggagaggag 1140
aggaaggccc cagaaaacca ggaggaagag gaggagcgtg cagaactgaa tcagtcggag 1200
gaacctgagg caggcgagag tagtactgga gggccttgag gggcccacag acagatccca 1260
tccatcagct cccttttctt tttcccttga actgttctgg cctcagacca actctctcct 1320
gtataatctc tctcctgtat aaccccacct tgccaagctt tcttctacaa ccagagcccc 1380
ccacaatgat gattaaacac ctgacacatc ttga                             1414

<210> 385
<211> 4138
<212> DNA
<213> Homo Sapiens

<300> 
<308> GenBank No. NM000459
<309> 2004-10-26  

<400> 385
cttctgtgct gttccttctt gcctctaact tgtaaacaag acgtactagg acgatgctaa 60
tggaaagtca caaaccgctg ggtttttgaa aggatccttg ggacctcatg cacatttgtg 120
gaaactggat ggagagattt ggggaagcat ggactcttta gccagcttag ttctctgtgg 180
agtcagcttg ctcctttctg gaactgtgga aggtgccatg gacttgatct tgatcaattc 240
cctacctctt gtatctgatg ctgaaacatc tctcacctgc attgcctctg ggtggcgccc 300
ccatgagccc atcaccatag gaagggactt tgaagcctta atgaaccagc accaggatcc 360
gctggaagtt actcaagatg tgaccagaga atgggctaaa aaagttgttt ggaagagaga 420
aaaggctagt aagatcaatg gtgcttattt ctgtgaaggg cgagttcgag gagaggcaat 480
caggatacga accatgaaga tgcgtcaaca agcttccttc ctaccagcta ctttaactat 540
gactgtggac aagggagata acgtgaacat atctttcaaa aaggtattga ttaaagaaga 600
agatgcagtg atttacaaaa atggttcctt catccattca gtgccccggc atgaagtacc 660
tgatattcta gaagtacacc tgcctcatgc tcagccccag gatgctggag tgtactcggc 720
caggtatata ggaggaaacc tcttcacctc ggccttcacc aggctgatag tccggagatg 780
tgaagcccag aagtggggac ctgaatgcaa ccatctctgt actgcttgta tgaacaatgg 840
tgtctgccat gaagatactg gagaatgcat ttgccctcct gggtttatgg gaaggacgtg 900
tgagaaggct tgtgaactgc acacgtttgg cagaacttgt aaagaaaggt gcagtggaca 960
agagggatgc aagtcttatg tgttctgtct ccctgacccc tatgggtgtt cctgtgccac 1020
aggctggaag ggtctgcagt gcaatgaagc atgccaccct ggtttttacg ggccagattg 1080
taagcttagg tgcagctgca acaatgggga gatgtgtgat cgcttccaag gatgtctctg 1140
ctctccagga tggcaggggc tccagtgtga gagagaaggc ataccgagga tgaccccaaa 1200
gatagtggat ttgccagatc atatagaagt aaacagtggt aaatttaatc ccatttgcaa 1260
agcttctggc tggccgctac ctactaatga agaaatgacc ctggtgaagc cggatgggac 1320
agtgctccat ccaaaagact ttaaccatac ggatcatttc tcagtagcca tattcaccat 1380
ccaccggatc ctcccccctg actcaggagt ttgggtctgc agtgtgaaca cagtggctgg 1440
gatggtggaa aagcccttca acatttctgt taaagttctt ccaaagcccc tgaatgcccc 1500
aaacgtgatt gacactggac ataactttgc tgtcatcaac atcagctctg agccttactt 1560
tggggatgga ccaatcaaat ccaagaagct tctatacaaa cccgttaatc actatgaggc 1620
ttggcaacat attcaagtga caaatgagat tgttacactc aactatttgg aacctcggac 1680
agaatatgaa ctctgtgtgc aactggtccg tcgtggagag ggtggggaag ggcatcctgg 1740
acctgtgaga cgcttcacaa cagcttctat cggactccct cctccaagag gtctaaatct 1800
cctgcctaaa agtcagacca ctctaaattt gacctggcaa ccaatatttc caagctcgga 1860
agatgacttt tatgttgaag tggagagaag gtctgtgcaa aaaagtgatc agcagaatat 1920
taaagttcca ggcaacttga cttcggtgct acttaacaac ttacatccca gggagcagta 1980
cgtggtccga gctagagtca acaccaaggc ccagggggaa tggagtgaag atctcactgc 2040
ttggaccctt agtgacattc ttcctcctca accagaaaac atcaagattt ccaacattac 2100
acactcctcg gctgtgattt cttggacaat attggatggc tattctattt cttctattac 2160
tatccgttac aaggttcaag gcaagaatga agaccagcac gttgatgtga agataaagaa 2220
tgccaccatc attcagtatc agctcaaggg cctagagcct gaaacagcat accaggtgga 2280
catttttgca gagaacaaca tagggtcaag caacccagcc ttttctcatg aactggtgac 2340
cctcccagaa tctcaagcac cagcggacct cggagggggg aagatgctgc ttatagccat 2400
ccttggctct gctggaatga cctgcctgac tgtgctgttg gcctttctga tcatattgca 2460
attgaagagg gcaaatgtgc aaaggagaat ggcccaagcc ttccaaaacg tgagggaaga 2520
accagctgtg cagttcaact cagggactct ggccctaaac aggaaggtca aaaacaaccc 2580
agatcctaca atttatccag tgcttgactg gaatgacatc aaatttcaag atgtgattgg 2640
ggagggcaat tttggccaag ttcttaaggc gcgcatcaag aaggatgggt tacggatgga 2700
tgctgccatc aaaagaatga aagaatatgc ctccaaagat gatcacaggg actttgcagg 2760
agaactggaa gttctttgta aacttggaca ccatccaaac atcatcaatc tcttaggagc 2820
atgtgaacat cgaggctact tgtacctggc cattgagtac gcgccccatg gaaaccttct 2880
ggacttcctt cgcaagagcc gtgtgctgga gacggaccca gcatttgcca ttgccaatag 2940
caccgcgtcc acactgtcct cccagcagct ccttcacttc gctgccgacg tggcccgggg 3000
catggactac ttgagccaaa aacagtttat ccacagggat ctggctgcca gaaacatttt 3060
agttggtgaa aactatgtgg caaaaatagc agattttgga ttgtcccgag gtcaagaggt 3120
gtacgtgaaa aagacaatgg gaaggctccc agtgcgctgg atggccatcg agtcactgaa 3180
ttacagtgtg tacacaacca acagtgatgt atggtcctat ggtgtgttac tatgggagat 3240
tgttagctta ggaggcacac cctactgcgg gatgacttgt gcagaactct acgagaagct 3300
gccccagggc tacagactgg agaagcccct gaactgtgat gatgaggtgt atgatctaat 3360
gagacaatgc tggcgggaga agccttatga gaggccatca tttgcccaga tattggtgtc 3420
cttaaacaga atgttagagg agcgaaagac ctacgtgaat accacgcttt atgagaagtt 3480
tacttatgca ggaattgact gttctgctga agaagcggcc taggacagaa catctgtata 3540
ccctctgttt ccctttcact ggcatgggag acccttgaca actgctgaga aaacatgcct 3600
ctgccaaagg atgtgatata taagtgtaca tatgtgctgg aattctaaca agtcataggt 3660
taatatttaa gacactgaaa aatctaagtg atataaatca gattcttctc tctcatttta 3720
tccctcacct gtagcatgcc agtcccgttt catttagtca tgtgaccact ctgtcttgtg 3780
tttccacagc ctgcaagttc agtccaggat gctaacatct aaaaatagac ttaaatctca 3840
ttgcttacaa gcctaagaat ctttagagaa gtatacataa gtttaggata aaataatggg 3900
attttctttt cttttctctg gtaatattga cttgtatatt ttaagaaata acagaaagcc 3960
tgggtgacat ttgggagaca tgtgacattt atatattgaa ttaatatccc tacatgtatt 4020
gcacattgta aaaagtttta gttttgatga gttgtgagtt taccttgtat actgtaggca 4080
cactttgcac tgatatatca tgagtgaata aatgtcttgc ctactcaaaa aaaaaaaa   4138

<210> 386
<211> 3960
<212> DNA
<213> Homo Sapiens

<300> 
<308> GenBank No. NM005424
<309> 2004-12-18  

<400> 386
cacaggctga gcagtcaggc ccacagcatc tgaccccagg cccagctcgt cctggctggc 60
ctgggtcggc ctctggagta tggtctggcg ggtgccccct ttcttgctcc ccatcctctt 120
cttggcttct catgtgggcg cggcggtgga cctgacgctg ctggccaacc tgcggctcac 180
ggacccccag cgcttcttcc tgacttgcgt gtctggggag gccggggcgg ggaggggctc 240
ggacgcctgg ggcccgcccc tgctgctgga gaaggacgac cgtatcgtgc gcaccccgcc 300
cgggccaccc ctgcgcctgg cgcgcaacgg ttcgcaccag gtcacgcttc gcggcttctc 360
caagccctcg gacctcgtgg gcgtcttctc ctgcgtgggc ggtgctgggg cgcggcgcac 420
gcgcgtcatc tacgtgcaca acagccctgg agcccacctg cttccagaca aggtcacaca 480
cactgtgaac aaaggtgaca ccgctgtact ttctgcacgt gtgcacaagg agaagcagac 540
agacgtgatc tggaagagca acggatccta cttctacacc ctggactggc atgaagccca 600
ggatgggcgg ttcctgctgc agctcccaaa tgtgcagcca ccatcgagcg gcatctacag 660
tgccacttac ctggaagcca gccccctggg cagcgccttc tttcggctca tcgtgcgggg 720
ttgtggggct gggcgctggg ggccaggctg taccaaggag tgcccaggtt gcctacatgg 780
aggtgtctgc cacgaccatg acggcgaatg tgtatgcccc cctggcttca ctggcacccg 840
ctgtgaacag gcctgcagag agggccgttt tgggcagagc tgccaggagc agtgcccagg 900
catatcaggc tgccggggcc tcaccttctg cctcccagac ccctatggct gctcttgtgg 960
atctggctgg agaggaagcc agtgccaaga agcttgtgcc cctggtcatt ttggggctga 1020
ttgccgactc cagtgccagt gtcagaatgg tggcacttgt gaccggttca gtggttgtgt 1080
ctgcccctct gggtggcatg gagtgcactg tgagaagtca gaccggatcc cccagatcct 1140
caacatggcc tcagaactgg agttcaactt agagacgatg ccccggatca actgtgcagc 1200
tgcagggaac cccttccccg tgcggggcag catagagcta cgcaagccag acggcactgt 1260
gctcctgtcc accaaggcca ttgtggagcc agagaagacc acagctgagt tcgaggtgcc 1320
ccgcttggtt cttgcggaca gtgggttctg ggagtgccgt gtgtccacat ctggcggcca 1380
agacagccgg cgcttcaagg tcaatgtgaa agtgcccccc gtgcccctgg ctgcacctcg 1440
gctcctgacc aagcagagcc gccagcttgt ggtctccccg ctggtctcgt tctctgggga 1500
tggacccatc tccactgtcc gcctgcacta ccggccccag gacagtacca tggactggtc 1560
gaccattgtg gtggacccca gtgagaacgt gacgttaatg aacctgaggc caaagacagg 1620
atacagtgtt cgtgtgcagc tgagccggcc aggggaagga ggagaggggg cctgggggcc 1680
tcccaccctc atgaccacag actgtcctga gcctttgttg cagccgtggt tggagggctg 1740
gcatgtggaa ggcactgacc ggctgcgagt gagctggtcc ttgcccttgg tgcccgggcc 1800
actggtgggc gacggtttcc tgctgcgcct gtgggacggg acacgggggc aggagcggcg 1860
ggagaacgtc tcatcccccc aggcccgcac tgccctcctg acgggactca cgcctggcac 1920
ccactaccag ctggatgtgc agctctacca ctgcaccctc ctgggcccgg cctcgccccc 1980
tgcacacgtg cttctgcccc ccagtgggcc tccagccccc cgacacctcc acgcccaggc 2040
cctctcagac tccgagatcc agctgacatg gaagcacccg gaggctctgc ctgggccaat 2100
atccaagtac gttgtggagg tgcaggtggc tgggggtgca ggagacccac tgtggataga 2160
cgtggacagg cctgaggaga caagcaccat catccgtggc ctcaacgcca gcacgcgcta 2220
cctcttccgc atgcgggcca gcattcaggg gctcggggac tggagcaaca cagtagaaga 2280
gtccaccctg ggcaacgggc tgcaggctga gggcccagtc caagagagcc gggcagctga 2340
agagggcctg gatcagcagc tgatcctggc ggtggtgggc tccgtgtctg ccacctgcct 2400
caccatcctg gccgcccttt taaccctggt gtgcatccgc agaagctgcc tgcatcggag 2460
acgcaccttc acctaccagt caggctcggg cgaggagacc atcctgcagt tcagctcagg 2520
gaccttgaca cttacccggc ggccaaaact gcagcccgag cccctgagct acccagtgct 2580
agagtgggag gacatcacct ttgaggacct catcggggag gggaacttcg gccaggtcat 2640
ccgggccatg atcaagaagg acgggctgaa gatgaacgca gccatcaaaa tgctgaaaga 2700
gtatgcctct gaaaatgacc atcgtgactt tgcgggagaa ctggaagttc tgtgcaaatt 2760
ggggcatcac cccaacatca tcaacctcct gggggcctgt aagaaccgag gttacttgta 2820
tatcgctatt gaatatgccc cctacgggaa cctgctagat tttctgcgga aaagccgggt 2880
cctagagact gacccagctt ttgctcgaga gcatgggaca gcctctaccc ttagctcccg 2940
gcagctgctg cgtttcgcca gtgatgcggc caatggcatg cagtacctga gtgagaagca 3000
gttcatccac agggacctgg ctgcccggaa tgtgctggtc ggagagaacc tagcctccaa 3060
gattgcagac ttcggccttt ctcggggaga ggaggtttat gtgaagaaga cgatggggcg 3120
tctccctgtg cgctggatgg ccattgagtc cctgaactac agtgtctata ccaccaagag 3180
tgatgtctgg tcctttggag tccttctttg ggagatagtg agccttggag gtacacccta 3240
ctgtggcatg acctgtgccg agctctatga aaagctgccc cagggctacc gcatggagca 3300
gcctcgaaac tgtgacgatg aagtgtacga gctgatgcgt cagtgctggc gggaccgtcc 3360
ctatgagcga cccccctttg cccagattgc gctacagcta ggccgcatgc tggaagccag 3420
gaaggcctat gtgaacatgt cgctgtttga gaacttcact tacgcgggca ttgatgccac 3480
agctgaggag gcctgagctg ccatccagcc agaacgtggc tctgctggcc ggagcaaact 3540
ctgctgtcta acctgtgacc agtctgaccc ttacagcctc tgacttaagc tgcctcaagg 3600
aattttttta acttaaggga gaaaaaaagg gatctgggga tggggtgggc ttaggggaac 3660
tgggttccca tgctttgtag gtgtctcata gctatcctgg gcatccttct ttctagttca 3720
gctgccccac aggtgtgttt cccatcccac tgctccccca acacaaaccc ccactccagc 3780
tccttcgctt aagccagcac tcacaccact aacatgccct gttcagctac tcccactccc 3840
ggcctgtcat tcagaaaaaa ataaatgttc taataagctc caaaaaaaaa aaaaaaaaaa 3900
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 3960

<210> 387
<211> 3682
<212> DNA
<213> Homo Sapiens

<300> 
<308> GenBank NM_001066
<309> 2003-12-20  

<400> 387
gcgagcgcag cggagcctgg agagaaggcg ctgggctgcg agggcgcgag ggcgcgaggg 60
cagggggcaa ccggaccccg cccgcaccca tggcgcccgt cgccgtctgg gccgcgctgg 120
ccgtcggact ggagctctgg gctgcggcgc acgccttgcc cgcccaggtg gcatttacac 180
cctacgcccc ggagcccggg agcacatgcc ggctcagaga atactatgac cagacagctc 240
agatgtgctg cagcaaatgc tcgccgggcc aacatgcaaa agtcttctgt accaagacct 300
cggacaccgt gtgtgactcc tgtgaggaca gcacatacac ccagctctgg aactgggttc 360
ccgagtgctt gagctgtggc tcccgctgta gctctgacca ggtggaaact caagcctgca 420
ctcgggaaca gaaccgcatc tgcacctgca ggcccggctg gtactgcgcg ctgagcaagc 480
aggaggggtg ccggctgtgc gcgccgctgc gcaagtgccg cccgggcttc ggcgtggcca 540
gaccaggaac tgaaacatca gacgtggtgt gcaagccctg tgccccgggg acgttctcca 600
acacgacttc atccacggat atttgcaggc cccaccagat ctgtaacgtg gtggccatcc 660
ctgggaatgc aagcatggat gcagtctgca cgtccacgtc ccccacccgg agtatggccc 720
caggggcagt acacttaccc cagccagtgt ccacacgatc ccaacacacg cagccaactc 780
cagaacccag cactgctcca agcacctcct tcctgctccc aatgggcccc agccccccag 840
ctgaagggag cactggcgac ttcgctcttc cagttggact gattgtgggt gtgacagcct 900
tgggtctact aataatagga gtggtgaact gtgtcatcat gacccaggtg aaaaagaagc 960
ccttgtgcct gcagagagaa gccaaggtgc ctcacttgcc tgccgataag gcccggggta 1020
cacagggccc cgagcagcag cacctgctga tcacagcgcc gagctccagc agcagctccc 1080
tggagagctc ggccagtgcg ttggacagaa gggcgcccac tcggaaccag ccacaggcac 1140
caggcgtgga ggccagtggg gccggggagg cccgggccag caccgggagc tcagattctt 1200
cccctggtgg ccatgggacc caggtcaatg tcacctgcat cgtgaacgtc tgtagcagct 1260
ctgaccacag ctcacagtgc tcctcccaag ccagctccac aatgggagac acagattcca 1320
gcccctcgga gtccccgaag gacgagcagg tccccttctc caaggaggaa tgtgcctttc 1380
ggtcacagct ggagacgcca gagaccctgc tggggagcac cgaagagaag cccctgcccc 1440
ttggagtgcc tgatgctggg atgaagccca gttaaccagg ccggtgtggg ctgtgtcgta 1500
gccaaggtgg gctgagccct ggcaggatga ccctgcgaag gggccctggt ccttccaggc 1560
ccccaccact aggactctga ggctctttct gggccaagtt cctctagtgc cctccacagc 1620
cgcagcctcc ctctgacctg caggccaaga gcagaggcag cgagttgtgg aaagcctctg 1680
ctgccatggc gtgtccctct cggaaggctg gctgggcatg gacgttcggg gcatgctggg 1740
gcaagtccct gactctctgt gacctgcccc gcccagctgc acctgccagc ctggcttctg 1800
gagcccttgg gttttttgtt tgtttgtttg tttgtttgtt tgtttctccc cctgggctct 1860
gccccagctc tggcttccag aaaaccccag catccttttc tgcagagggg ctttctggag 1920
aggagggatg ctgcctgagt cacccatgaa gacaggacag tgcttcagcc tgaggctgag 1980
actgcgggat ggtcctgggg ctctgtgcag ggaggaggtg gcagccctgt agggaacggg 2040
gtccttcaag ttagctcagg aggcttggaa agcatcacct caggccaggt gcagtggctc 2100
acgcctatga tcccagcact ttgggaggct gaggcgggtg gatcacctga ggttaggagt 2160
tcgagaccag cctggccaac atggtaaaac cccatctcta ctaaaaatac agaaattagc 2220
cgggcgtggt ggcgggcacc tatagtccca gctactcaga agcctgaggc tgggaaatcg 2280
tttgaacccg ggaagcggag gttgcaggga gccgagatca cgccactgca ctccagcctg 2340
ggcgacagag cgagagtctg tctcaaaaga aaaaaaaaag caccgcctcc aaatgccaac 2400
ttgtcctttt gtaccatggt gtgaaagtca gatgcccaga gggcccaggc aggccaccat 2460
attcagtgct gtggcctggg caagataacg cacttctaac tagaaatctg ccaatttttt 2520
aaaaaagtaa gtaccactca ggccaacaag ccaacgacaa agccaaactc tgccagccac 2580
atccaacccc ccacctgcca tttgcaccct ccgccttcac tccggtgtgc ctgcagcccc 2640
gcgcctcctt ccttgctgtc ctaggccaca ccatctcctt tcagggaatt tcaggaacta 2700
gagatgactg agtcctcgta gccatctctc tactcctacc tcagcctaga ccctcctcct 2760
cccccagagg ggtgggttcc tcttccccac tccccacctt caattcctgg gccccaaacg 2820
ggctgccctg ccactttggt acatggccag tgtgatccca agtgccagtc ttgtgtctgc 2880
gtctgtgttg cgtgtcgtgg gtgtgtgtag ccaaggtcgg taagttgaat ggcctgcctt 2940
gaagccactg aagctgggat tcctccccat tagagtcagc cttccccctc ccagggccag 3000
ggccctgcag aggggaaacc agtgtagcct tgcccggatt ctgggaggaa gcaggttgag 3060
gggctcctgg aaaggctcag tctcaggagc atggggataa aggagaaggc atgaaattgt 3120
ctagcagagc aggggcaggg tgataaattg ttgataaatt ccactggact tgagcttggc 3180
agctgaacta ttggagggtg ggagagccca gccattacca tggagacaag aagggttttc 3240
caccctggaa tcaagatgtc agactggctg gctgcagtga cgtgcacctg tactcaggag 3300
gctgagggga ggatcactgg agcccaggag tttgaggctg cagcgagcta tgatcgcgcc 3360
actacactcc agcctgagca acagagtgag accctgtctc ttaaagaaaa aaaaagtcag 3420
actgctggga ctggccaggt ttctgcccac attggaccca catgaggaca tgatggagcg 3480
cacctgcccc ctggtggaca gtcctgggag aacctcaggc ttccttggca tcacagggca 3540
gagccgggaa gcgatgaatt tggagactct gtggggcctt ggttcccttg tgtgtgtgtg 3600
ttgatcccaa gacaatgaaa gtttgcactg tatgctggac ggcattcctg cttatcaata 3660
aacctgtttg ttttaaaaaa aa                                          3682

<210> 388
<211> 2236
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM001065
<309> 2004-10-27  

<400> 388
gctgttgcaa cactgcctca ctcttcccct cccaccttct ctcccctcct ctctgcttta 60
attttctcag aattctctgg actgaggctc cagttctggc ctttggggtt caagatcact 120
gggaccaggc cgtgatctct atgcccgagt ctcaaccctc aactgtcacc ccaaggcact 180
tgggacgtcc tggacagacc gagtcccggg aagccccagc actgccgctg ccacactgcc 240
ctgagcccaa atgggggagt gagaggccat agctgtctgg catgggcctc tccaccgtgc 300
ctgacctgct gctgccactg gtgctcctgg agctgttggt gggaatatac ccctcagggg 360
ttattggact ggtccctcac ctaggggaca gggagaagag agatagtgtg tgtccccaag 420
gaaaatatat ccaccctcaa aataattcga tttgctgtac caagtgccac aaaggaacct 480
acttgtacaa tgactgtcca ggcccggggc aggatacgga ctgcagggag tgtgagagcg 540
gctccttcac cgcttcagaa aaccacctca gacactgcct cagctgctcc aaatgccgaa 600
aggaaatggg tcaggtggag atctcttctt gcacagtgga ccgggacacc gtgtgtggct 660
gcaggaagaa ccagtaccgg cattattgga gtgaaaacct tttccagtgc ttcaattgca 720
gcctctgcct caatgggacc gtgcacctct cctgccagga gaaacagaac accgtgtgca 780
cctgccatgc aggtttcttt ctaagagaaa acgagtgtgt ctcctgtagt aactgtaaga 840
aaagcctgga gtgcacgaag ttgtgcctac cccagattga gaatgttaag ggcactgagg 900
actcaggcac cacagtgctg ttgcccctgg tcattttctt tggtctttgc cttttatccc 960
tcctcttcat tggtttaatg tatcgctacc aacggtggaa gtccaagctc tactccattg 1020
tttgtgggaa atcgacacct gaaaaagagg gggagcttga aggaactact actaagcccc 1080
tggccccaaa cccaagcttc agtcccactc caggcttcac ccccaccctg ggcttcagtc 1140
ccgtgcccag ttccaccttc acctccagct ccacctatac ccccggtgac tgtcccaact 1200
ttgcggctcc ccgcagagag gtggcaccac cctatcaggg ggctgacccc atccttgcga 1260
cagccctcgc ctccgacccc atccccaacc cccttcagaa gtgggaggac agcgcccaca 1320
agccacagag cctagacact gatgaccccg cgacgctgta cgccgtggtg gagaacgtgc 1380
ccccgttgcg ctggaaggaa ttcgtgcggc gcctagggct gagcgaccac gagatcgatc 1440
ggctggagct gcagaacggg cgctgcctgc gcgaggcgca atacagcatg ctggcgacct 1500
ggaggcggcg cacgccgcgg cgcgaggcca cgctggagct gctgggacgc gtgctccgcg 1560
acatggacct gctgggctgc ctggaggaca tcgaggaggc gctttgcggc cccgccgccc 1620
tcccgcccgc gcccagtctt ctcagatgag gctgcgcccc tgcgggcagc tctaaggacc 1680
gtcctgcgag atcgccttcc aaccccactt ttttctggaa aggaggggtc ctgcaggggc 1740
aagcaggagc tagcagccgc ctacttggtg ctaacccctc gatgtacata gcttttctca 1800
gctgcctgcg cgccgccgac agtcagcgct gtgcgcgcgg agagaggtgc gccgtgggct 1860
caagagcctg agtgggtggt ttgcgaggat gagggacgct atgcctcatg cccgttttgg 1920
gtgtcctcac cagcaaggct gctcgggggc ccctggttcg tccctgagcc tttttcacag 1980
tgcataagca gttttttttg tttttgtttt gttttgtttt gtttttaaat caatcatgtt 2040
acactaatag aaacttggca ctcctgtgcc ctctgcctgg acaagcacat agcaagctga 2100
actgtcctaa ggcaggggcg agcacggaac aatggggcct tcagctggag ctgtggactt 2160
ttgtacatac actaaaattc tgaagttaaa gctctgctct tggaaaaaaa aaaaaaaaaa 2220
aaaaaaaaaa aaaaaa                                                 2236

<210> 389
<211> 5777
<212> DNA
<213> Homo Sapiens

<300> 
<308> GenBank No. NM002019
<309> 2004-10-28  

<400> 389
gcggacactc ctctcggctc ctccccggca gcggcggcgg ctcggagcgg gctccggggc 60
tcgggtgcag cggccagcgg gcctggcggc gaggattacc cggggaagtg gttgtctcct 120
ggctggagcc gcgagacggg cgctcagggc gcggggccgg cggcggcgaa cgagaggacg 180
gactctggcg gccgggtcgt tggccggggg agcgcgggca ccgggcgagc aggccgcgtc 240
gcgctcacca tggtcagcta ctgggacacc ggggtcctgc tgtgcgcgct gctcagctgt 300
ctgcttctca caggatctag ttcaggttca aaattaaaag atcctgaact gagtttaaaa 360
ggcacccagc acatcatgca agcaggccag acactgcatc tccaatgcag gggggaagca 420
gcccataaat ggtctttgcc tgaaatggtg agtaaggaaa gcgaaaggct gagcataact 480
aaatctgcct gtggaagaaa tggcaaacaa ttctgcagta ctttaacctt gaacacagct 540
caagcaaacc acactggctt ctacagctgc aaatatctag ctgtacctac ttcaaagaag 600
aaggaaacag aatctgcaat ctatatattt attagtgata caggtagacc tttcgtagag 660
atgtacagtg aaatccccga aattatacac atgactgaag gaagggagct cgtcattccc 720
tgccgggtta cgtcacctaa catcactgtt actttaaaaa agtttccact tgacactttg 780
atccctgatg gaaaacgcat aatctgggac agtagaaagg gcttcatcat atcaaatgca 840
acgtacaaag aaatagggct tctgacctgt gaagcaacag tcaatgggca tttgtataag 900
acaaactatc tcacacatcg acaaaccaat acaatcatag atgtccaaat aagcacacca 960
cgcccagtca aattacttag aggccatact cttgtcctca attgtactgc taccactccc 1020
ttgaacacga gagttcaaat gacctggagt taccctgatg aaaaaaataa gagagcttcc 1080
gtaaggcgac gaattgacca aagcaattcc catgccaaca tattctacag tgttcttact 1140
attgacaaaa tgcagaacaa agacaaagga ctttatactt gtcgtgtaag gagtggacca 1200
tcattcaaat ctgttaacac ctcagtgcat atatatgata aagcattcat cactgtgaaa 1260
catcgaaaac agcaggtgct tgaaaccgta gctggcaagc ggtcttaccg gctctctatg 1320
aaagtgaagg catttccctc gccggaagtt gtatggttaa aagatgggtt acctgcgact 1380
gagaaatctg ctcgctattt gactcgtggc tactcgttaa ttatcaagga cgtaactgaa 1440
gaggatgcag ggaattatac aatcttgctg agcataaaac agtcaaatgt gtttaaaaac 1500
ctcactgcca ctctaattgt caatgtgaaa ccccagattt acgaaaaggc cgtgtcatcg 1560
tttccagacc cggctctcta cccactgggc agcagacaaa tcctgacttg taccgcatat 1620
ggtatccctc aacctacaat caagtggttc tggcacccct gtaaccataa tcattccgaa 1680
gcaaggtgtg acttttgttc caataatgaa gagtccttta tcctggatgc tgacagcaac 1740
atgggaaaca gaattgagag catcactcag cgcatggcaa taatagaagg aaagaataag 1800
atggctagca ccttggttgt ggctgactct agaatttctg gaatctacat ttgcatagct 1860
tccaataaag ttgggactgt gggaagaaac ataagctttt atatcacaga tgtgccaaat 1920
gggtttcatg ttaacttgga aaaaatgccg acggaaggag aggacctgaa actgtcttgc 1980
acagttaaca agttcttata cagagacgtt acttggattt tactgcggac agttaataac 2040
agaacaatgc actacagtat tagcaagcaa aaaatggcca tcactaagga gcactccatc 2100
actcttaatc ttaccatcat gaatgtttcc ctgcaagatt caggcaccta tgcctgcaga 2160
gccaggaatg tatacacagg ggaagaaatc ctccagaaga aagaaattac aatcagagat 2220
caggaagcac catacctcct gcgaaacctc agtgatcaca cagtggccat cagcagttcc 2280
accactttag actgtcatgc taatggtgtc cccgagcctc agatcacttg gtttaaaaac 2340
aaccacaaaa tacaacaaga gcctggaatt attttaggac caggaagcag cacgctgttt 2400
attgaaagag tcacagaaga ggatgaaggt gtctatcact gcaaagccac caaccagaag 2460
ggctctgtgg aaagttcagc atacctcact gttcaaggaa cctcggacaa gtctaatctg 2520
gagctgatca ctctaacatg cacctgtgtg gctgcgactc tcttctggct cctattaacc 2580
ctccttatcc gaaaaatgaa aaggtcttct tctgaaataa agactgacta cctatcaatt 2640
ataatggacc cagatgaagt tcctttggat gagcagtgtg agcggctccc ttatgatgcc 2700
agcaagtggg agtttgcccg ggagagactt aaactgggca aatcacttgg aagaggggct 2760
tttggaaaag tggttcaagc atcagcattt ggcattaaga aatcacctac gtgccggact 2820
gtggctgtga aaatgctgaa agagggggcc acggccagcg agtacaaagc tctgatgact 2880
gagctaaaaa tcttgaccca cattggccac catctgaacg tggttaacct gctgggagcc 2940
tgcaccaagc aaggagggcc tctgatggtg attgttgaat actgcaaata tggaaatctc 3000
tccaactacc tcaagagcaa acgtgactta ttttttctca acaaggatgc agcactacac 3060
atggagccta agaaagaaaa aatggagcca ggcctggaac aaggcaagaa accaagacta 3120
gatagcgtca ccagcagcga aagctttgcg agctccggct ttcaggaaga taaaagtctg 3180
agtgatgttg aggaagagga ggattctgac ggtttctaca aggagcccat cactatggaa 3240
gatctgattt cttacagttt tcaagtggcc agaggcatgg agttcctgtc ttccagaaag 3300
tgcattcatc gggacctggc agcgagaaac attcttttat ctgagaacaa cgtggtgaag 3360
atttgtgatt ttggccttgc ccgggatatt tataagaacc ccgattatgt gagaaaagga 3420
gatactcgac ttcctctgaa atggatggct cccgaatcta tctttgacaa aatctacagc 3480
accaagagcg acgtgtggtc ttacggagta ttgctgtggg aaatcttctc cttaggtggg 3540
tctccatacc caggagtaca aatggatgag gacttttgca gtcgcctgag ggaaggcatg 3600
aggatgagag ctcctgagta ctctactcct gaaatctatc agatcatgct ggactgctgg 3660
cacagagacc caaaagaaag gccaagattt gcagaacttg tggaaaaact aggtgatttg 3720
cttcaagcaa atgtacaaca ggatggtaaa gactacatcc caatcaatgc catactgaca 3780
ggaaatagtg ggtttacata ctcaactcct gccttctctg aggacttctt caaggaaagt 3840
atttcagctc cgaagtttaa ttcaggaagc tctgatgatg tcagatatgt aaatgctttc 3900
aagttcatga gcctggaaag aatcaaaacc tttgaagaac ttttaccgaa tgccacctcc 3960
atgtttgatg actaccaggg cgacagcagc actctgttgg cctctcccat gctgaagcgc 4020
ttcacctgga ctgacagcaa acccaaggcc tcgctcaaga ttgacttgag agtaaccagt 4080
aaaagtaagg agtcggggct gtctgatgtc agcaggccca gtttctgcca ttccagctgt 4140
gggcacgtca gcgaaggcaa gcgcaggttc acctacgacc acgctgagct ggaaaggaaa 4200
atcgcgtgct gctccccgcc cccagactac aactcggtgg tcctgtactc caccccaccc 4260
atctagagtt tgacacgaag ccttatttct agaagcacat gtgtatttat acccccagga 4320
aactagcttt tgccagtatt atgcatatat aagtttacac ctttatcttt ccatgggagc 4380
cagctgcttt ttgtgatttt tttaatagtg cttttttttt ttgactaaca agaatgtaac 4440
tccagataga gaaatagtga caagtgaaga acactactgc taaatcctca tgttactcag 4500
tgttagagaa atccttccta aacccaatga cttccctgct ccaacccccg ccacctcagg 4560
gcacgcagga ccagtttgat tgaggagctg cactgatcac ccaatgcatc acgtacccca 4620
ctgggccagc cctgcagccc aaaacccagg gcaacaagcc cgttagcccc aggggatcac 4680
tggctggcct gagcaacatc tcgggagtcc tctagcaggc ctaagacatg tgaggaggaa 4740
aaggaaaaaa agcaaaaagc aagggagaaa agagaaaccg ggagaaggca tgagaaagaa 4800
tttgagacgc accatgtggg cacggagggg gacggggctc agcaatgcca tttcagtggc 4860
ttcccagctc tgacccttct acatttgagg gcccagccag gagcagatgg acagcgatga 4920
ggggacattt tctggattct gggaggcaag aaaaggacaa atatcttttt tggaactaaa 4980
gcaaatttta gacctttacc tatggaagtg gttctatgtc cattctcatt cgtggcatgt 5040
tttgatttgt agcactgagg gtggcactca actctgagcc catacttttg gctcctctag 5100
taagatgcac tgaaaactta gccagagtta ggttgtctcc aggccatgat ggccttacac 5160
tgaaaatgtc acattctatt ttgggtatta atatatagtc cagacactta actcaatttc 5220
ttggtattat tctgttttgc acagttagtt gtgaaagaaa gctgagaaga atgaaaatgc 5280
agtcctgagg agagttttct ccatatcaaa acgagggctg atggaggaaa aaggtcaata 5340
aggtcaaggg aagaccccgt ctctatacca accaaaccaa ttcaccaaca cagttgggac 5400
ccaaaacaca ggaagtcagt cacgtttcct tttcatttaa tggggattcc actatctcac 5460
actaatctga aaggatgtgg aagagcatta gctggcgcat attaagcact ttaagctcct 5520
tgagtaaaaa ggtggtatgt aatttatgca aggtatttct ccagttggga ctcaggatat 5580
tagttaatga gccatcacta gaagaaaagc ccattttcaa ctgctttgaa acttgcctgg 5640
ggtctgagca tgatgggaat agggagacag ggtaggaaag ggcgcctact cttcagggtc 5700
taaagatcaa gtgggccttg gatcgctaag ctggctctgt ttgatgctat ttatgcaagt 5760
tagggtctat gtattta                                                5777

<210> 390
<211> 5830
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM002253
<309> 2004-10-26  

<400> 390
actgagtccc gggaccccgg gagagcggtc agtgtgtggt cgctgcgttt cctctgcctg 60
cgccgggcat cacttgcgcg ccgcagaaag tccgtctggc agcctggata tcctctccta 120
ccggcacccg cagacgcccc tgcagccgcc ggtcggcgcc cgggctccct agccctgtgc 180
gctcaactgt cctgcgctgc ggggtgccgc gagttccacc tccgcgcctc cttctctaga 240
caggcgctgg gagaaagaac cggctcccga gttctgggca tttcgcccgg ctcgaggtgc 300
aggatgcaga gcaaggtgct gctggccgtc gccctgtggc tctgcgtgga gacccgggcc 360
gcctctgtgg gtttgcctag tgtttctctt gatctgccca ggctcagcat acaaaaagac 420
atacttacaa ttaaggctaa tacaactctt caaattactt gcaggggaca gagggacttg 480
gactggcttt ggcccaataa tcagagtggc agtgagcaaa gggtggaggt gactgagtgc 540
agcgatggcc tcttctgtaa gacactcaca attccaaaag tgatcggaaa tgacactgga 600
gcctacaagt gcttctaccg ggaaactgac ttggcctcgg tcatttatgt ctatgttcaa 660
gattacagat ctccatttat tgcttctgtt agtgaccaac atggagtcgt gtacattact 720
gagaacaaaa acaaaactgt ggtgattcca tgtctcgggt ccatttcaaa tctcaacgtg 780
tcactttgtg caagataccc agaaaagaga tttgttcctg atggtaacag aatttcctgg 840
gacagcaaga agggctttac tattcccagc tacatgatca gctatgctgg catggtcttc 900
tgtgaagcaa aaattaatga tgaaagttac cagtctatta tgtacatagt tgtcgttgta 960
gggtatagga tttatgatgt ggttctgagt ccgtctcatg gaattgaact atctgttgga 1020
gaaaagcttg tcttaaattg tacagcaaga actgaactaa atgtggggat tgacttcaac 1080
tgggaatacc cttcttcgaa gcatcagcat aagaaacttg taaaccgaga cctaaaaacc 1140
cagtctggga gtgagatgaa gaaatttttg agcaccttaa ctatagatgg tgtaacccgg 1200
agtgaccaag gattgtacac ctgtgcagca tccagtgggc tgatgaccaa gaagaacagc 1260
acatttgtca gggtccatga aaaacctttt gttgcttttg gaagtggcat ggaatctctg 1320
gtggaagcca cggtggggga gcgtgtcaga atccctgcga agtaccttgg ttacccaccc 1380
ccagaaataa aatggtataa aaatggaata ccccttgagt ccaatcacac aattaaagcg 1440
gggcatgtac tgacgattat ggaagtgagt gaaagagaca caggaaatta cactgtcatc 1500
cttaccaatc ccatttcaaa ggagaagcag agccatgtgg tctctctggt tgtgtatgtc 1560
ccaccccaga ttggtgagaa atctctaatc tctcctgtgg attcctacca gtacggcacc 1620
actcaaacgc tgacatgtac ggtctatgcc attcctcccc cgcatcacat ccactggtat 1680
tggcagttgg aggaagagtg cgccaacgag cccagccaag ctgtctcagt gacaaaccca 1740
tacccttgtg aagaatggag aagtgtggag gacttccagg gaggaaataa aattgaagtt 1800
aataaaaatc aatttgctct aattgaagga aaaaacaaaa ctgtaagtac ccttgttatc 1860
caagcggcaa atgtgtcagc tttgtacaaa tgtgaagcgg tcaacaaagt cgggagagga 1920
gagagggtga tctccttcca cgtgaccagg ggtcctgaaa ttactttgca acctgacatg 1980
cagcccactg agcaggagag cgtgtctttg tggtgcactg cagacagatc tacgtttgag 2040
aacctcacat ggtacaagct tggcccacag cctctgccaa tccatgtggg agagttgccc 2100
acacctgttt gcaagaactt ggatactctt tggaaattga atgccaccat gttctctaat 2160
agcacaaatg acattttgat catggagctt aagaatgcat ccttgcagga ccaaggagac 2220
tatgtctgcc ttgctcaaga caggaagacc aagaaaagac attgcgtggt caggcagctc 2280
acagtcctag agcgtgtggc acccacgatc acaggaaacc tggagaatca gacgacaagt 2340
attggggaaa gcatcgaagt ctcatgcacg gcatctggga atccccctcc acagatcatg 2400
tggtttaaag ataatgagac ccttgtagaa gactcaggca ttgtattgaa ggatgggaac 2460
cggaacctca ctatccgcag agtgaggaag gaggacgaag gcctctacac ctgccaggca 2520
tgcagtgttc ttggctgtgc aaaagtggag gcatttttca taatagaagg tgcccaggaa 2580
aagacgaact tggaaatcat tattctagta ggcacggcgg tgattgccat gttcttctgg 2640
ctacttcttg tcatcatcct acggaccgtt aagcgggcca atggagggga actgaagaca 2700
ggctacttgt ccatcgtcat ggatccagat gaactcccat tggatgaaca ttgtgaacga 2760
ctgccttatg atgccagcaa atgggaattc cccagagacc ggctgaagct aggtaagcct 2820
cttggccgtg gtgcctttgg ccaagtgatt gaagcagatg cctttggaat tgacaagaca 2880
gcaacttgca ggacagtagc agtcaaaatg ttgaaagaag gagcaacaca cagtgagcat 2940
cgagctctca tgtctgaact caagatcctc attcatattg gtcaccatct caatgtggtc 3000
aaccttctag gtgcctgtac caagccagga gggccactca tggtgattgt ggaattctgc 3060
aaatttggaa acctgtccac ttacctgagg agcaagagaa atgaatttgt cccctacaag 3120
accaaagggg cacgattccg tcaagggaaa gactacgttg gagcaatccc tgtggatctg 3180
aaacggcgct tggacagcat caccagtagc cagagctcag ccagctctgg atttgtggag 3240
gagaagtccc tcagtgatgt agaagaagag gaagctcctg aagatctgta taaggacttc 3300
ctgaccttgg agcatctcat ctgttacagc ttccaagtgg ctaagggcat ggagttcttg 3360
gcatcgcgaa agtgtatcca cagggacctg gcggcacgaa atatcctctt atcggagaag 3420
aacgtggtta aaatctgtga ctttggcttg gcccgggata tttataaaga tccagattat 3480
gtcagaaaag gagatgctcg cctccctttg aaatggatgg ccccagaaac aatttttgac 3540
agagtgtaca caatccagag tgacgtctgg tcttttggtg ttttgctgtg ggaaatattt 3600
tccttaggtg cttctccata tcctggggta aagattgatg aagaattttg taggcgattg 3660
aaagaaggaa ctagaatgag ggcccctgat tatactacac cagaaatgta ccagaccatg 3720
ctggactgct ggcacgggga gcccagtcag agacccacgt tttcagagtt ggtggaacat 3780
ttgggaaatc tcttgcaagc taatgctcag caggatggca aagactacat tgttcttccg 3840
atatcagaga ctttgagcat ggaagaggat tctggactct ctctgcctac ctcacctgtt 3900
tcctgtatgg aggaggagga agtatgtgac cccaaattcc attatgacaa cacagcagga 3960
atcagtcagt atctgcagaa cagtaagcga aagagccggc ctgtgagtgt aaaaacattt 4020
gaagatatcc cgttagaaga accagaagta aaagtaatcc cagatgacaa ccagacggac 4080
agtggtatgg ttcttgcctc agaagagctg aaaactttgg aagacagaac caaattatct 4140
ccatcttttg gtggaatggt gcccagcaaa agcagggagt ctgtggcatc tgaaggctca 4200
aaccagacaa gcggctacca gtccggatat cactccgatg acacagacac caccgtgtac 4260
tccagtgagg aagcagaact tttaaagctg atagagattg gagtgcaaac cggtagcaca 4320
gcccagattc tccagcctga ctcggggacc acactgagct ctcctcctgt ttaaaaggaa 4380
gcatccacac cccaactccc ggacatcaca tgagaggtct gctcagattt tgaagtgttg 4440
ttctttccac cagcaggaag tagccgcatt tgattttcat ttcgacaaca gaaaaaggac 4500
ctcggactgc agggagccag tcttctaggc atatcctgga agaggcttgt gacccaagaa 4560
tgtgtctgtg tcttctccca gtgttgacct gatcctcttt tttcattcat ttaaaaagca 4620
ttatcatgcc cctgctgcgg gtctcaccat gggtttagaa caaagagctt caagcaatgg 4680
ccccatcctc aaagaagtag cagtacctgg ggagctgaca cttctgtaaa actagaagat 4740
aaaccaggca acgtaagtgt tcgaggtgtt gaagatggga aggatttgca gggctgagtc 4800
tatccaagag gctttgttta ggacgtgggt cccaagccaa gccttaagtg tggaattcgg 4860
attgatagaa aggaagacta acgttacctt gctttggaga gtactggagc ctgcaaatgc 4920
attgtgtttg ctctggtgga ggtgggcatg gggtctgttc tgaaatgtaa agggttcaga 4980
cggggtttct ggttttagaa ggttgcgtgt tcttcgagtt gggctaaagt agagttcgtt 5040
gtgctgtttc tgactcctaa tgagagttcc ttccagaccg ttagctgtct ccttgccaag 5100
ccccaggaag aaaatgatgc agctctggct ccttgtctcc caggctgatc ctttattcag 5160
aataccacaa agaaaggaca ttcagctcaa ggctccctgc cgtgttgaag agttctgact 5220
gcacaaacca gcttctggtt tcttctggaa tgaataccct catatctgtc ctgatgtgat 5280
atgtctgaga ctgaatgcgg gaggttcaat gtgaagctgt gtgtggtgtc aaagtttcag 5340
gaaggatttt acccttttgt tcttccccct gtccccaacc cactctcacc ccgcaaccca 5400
tcagtatttt agttatttgg cctctactcc agtaaacctg attgggtttg ttcactctct 5460
gaatgattat tagccagact tcaaaattat tttatagccc aaattataac atctattgta 5520
ttatttagac ttttaacata tagagctatt tctactgatt tttgcccttg ttctgtcctt 5580
tttttcaaaa aagaaaatgt gttttttgtt tggtaccata gtgtgaaatg ctgggaacaa 5640
tgactataag acatgctatg gcacatatat ttatagtctg tttatgtaga aacaaatgta 5700
atatattaaa gccttatata taatgaactt tgtactattc acattttgta tcagtattat 5760
gtagcataac aaaggtcata atgctttcag caattgatgt cattttatta aagaacattg 5820
aaaaacttga                                                        5830

<210> 391
<211> 4450
<212> DNA
<213> Homo Sapiens

<300> 
<308> GenBank No. NM002020
<309> 2004-12-18  

<400> 391
acccacgcgc agcggccgga gatgcagcgg ggcgccgcgc tgtgcctgcg actgtggctc 60
tgcctgggac tcctggacgg cctggtgagt gactactcca tgaccccccc gaccttgaac 120
atcacggagg agtcacacgt catcgacacc ggtgacagcc tgtccatctc ctgcagggga 180
cagcaccccc tcgagtgggc ttggccagga gctcaggagg cgccagccac cggagacaag 240
gacagcgagg acacgggggt ggtgcgagac tgcgagggca cagacgccag gccctactgc 300
aaggtgttgc tgctgcacga ggtacatgcc aacgacacag gcagctacgt ctgctactac 360
aagtacatca aggcacgcat cgagggcacc acggccgcca gctcctacgt gttcgtgaga 420
gactttgagc agccattcat caacaagcct gacacgctct tggtcaacag gaaggacgcc 480
atgtgggtgc cctgtctggt gtccatcccc ggcctcaatg tcacgctgcg ctcgcaaagc 540
tcggtgctgt ggccagacgg gcaggaggtg gtgtgggatg accggcgggg catgctcgtg 600
tccacgccac tgctgcacga tgccctgtac ctgcagtgcg agaccacctg gggagaccag 660
gacttccttt ccaacccctt cctggtgcac atcacaggca acgagctcta tgacatccag 720
ctgttgccca ggaagtcgct ggagctgctg gtaggggaga agctggtcct caactgcacc 780
gtgtgggctg agtttaactc aggtgtcacc tttgactggg actacccagg gaagcaggca 840
gagcggggta agtgggtgcc cgagcgacgc tcccaacaga cccacacaga actctccagc 900
atcctgacca tccacaacgt cagccagcac gacctgggct cgtatgtgtg caaggccaac 960
aacggcatcc agcgatttcg ggagagcacc gaggtcattg tgcatgaaaa tcccttcatc 1020
agcgtcgagt ggctcaaagg acccatcctg gaggccacgg caggagacga gctggtgaag 1080
ctgcccgtga agctggcagc gtaccccccg cccgagttcc agtggtacaa ggatggaaag 1140
gcactgtccg ggcgccacag tccacatgcc ctggtgctca aggaggtgac agaggccagc 1200
acaggcacct acaccctcgc cctgtggaac tccgctgctg gcctgaggcg caacatcagc 1260
ctggagctgg tggtgaatgt gcccccccag atacatgaga aggaggcctc ctcccccagc 1320
atctactcgc gtcacagccg ccaggccctc acctgcacgg cctacggggt gcccctgcct 1380
ctcagcatcc agtggcactg gcggccctgg acaccctgca agatgtttgc ccagcgtagt 1440
ctccggcggc ggcagcagca agacctcatg ccacagtgcc gtgactggag ggcggtgacc 1500
acgcaggatg ccgtgaaccc catcgagagc ctggacacct ggaccgagtt tgtggaggga 1560
aagaataaga ctgtgagcaa gctggtgatc cagaatgcca acgtgtctgc catgtacaag 1620
tgtgtggtct ccaacaaggt gggccaggat gagcggctca tctacttcta tgtgaccacc 1680
atccccgacg gcttcaccat cgaatccaag ccatccgagg agctactaga gggccagccg 1740
gtgctcctga gctgccaagc cgacagctac aagtacgagc atctgcgctg gtaccgcctc 1800
aacctgtcca cgctgcacga tgcgcacggg aacccgcttc tgctcgactg caagaacgtg 1860
catctgttcg ccacccctct ggccgccagc ctggaggagg tggcacctgg ggcgcgccac 1920
gccacgctca gcctgagtat cccccgcgtc gcgcccgagc acgagggcca ctatgtgtgc 1980
gaagtgcaag accggcgcag ccatgacaag cactgccaca agaagtacct gtcggtgcag 2040
gccctggaag cccctcggct cacgcagaac ttgaccgacc tcctggtgaa cgtgagcgac 2100
tcgctggaga tgcagtgctt ggtggccgga gcgcacgcgc ccagcatcgt gtggtacaaa 2160
gacgagaggc tgctggagga aaagtctgga gtcgacttgg cggactccaa ccagaagctg 2220
agcatccagc gcgtgcgcga ggaggatgcg ggaccgtatc tgtgcagcgt gtgcagaccc 2280
aagggctgcg tcaactcctc cgccagcgtg gccgtggaag gctccgagga taagggcagc 2340
atggagatcg tgatccttgt cggtaccggc gtcatcgctg tcttcttctg ggtcctcctc 2400
ctcctcatct tctgtaacat gaggaggccg gcccacgcag acatcaagac gggctacctg 2460
tccatcatca tggaccccgg ggaggtgcct ctggaggagc aatgcgaata cctgtcctac 2520
gatgccagcc agtgggaatt cccccgagag cggctgcacc tggggagagt gctcggctac 2580
ggcgccttcg ggaaggtggt ggaagcctcc gctttcggca tccacaaggg cagcagctgt 2640
gacaccgtgg ccgtgaaaat gctgaaagag ggcgccacgg ccagcgagca gcgcgcgctg 2700
atgtcggagc tcaagatcct cattcacatc ggcaaccacc tcaacgtggt caacctcctc 2760
ggggcgtgca ccaagccgca gggccccctc atggtgatcg tggagttctg caagtacggc 2820
aacctctcca acttcctgcg cgccaagcgg gacgccttca gcccctgcgc ggagaagtct 2880
cccgagcagc gcggacgctt ccgcgccatg gtggagctcg ccaggctgga tcggaggcgg 2940
ccggggagca gcgacagggt cctcttcgcg cggttctcga agaccgaggg cggagcgagg 3000
cgggcttctc cagaccaaga agctgaggac ctgtggctga gcccgctgac catggaagat 3060
cttgtctgct acagcttcca ggtggccaga gggatggagt tcctggcttc ccgaaagtgc 3120
atccacagag acctggctgc tcggaacatt ctgctgtcgg aaagcgacgt ggtgaagatc 3180
tgtgactttg gccttgcccg ggacatctac aaagaccccg actacgtccg caagggcagt 3240
gcccggctgc ccctgaagtg gatggcccct gaaagcatct tcgacaaggt gtacaccacg 3300
cagagtgacg tgtggtcctt tggggtgctt ctctgggaga tcttctctct gggggcctcc 3360
ccgtaccctg gggtgcagat caatgaggag ttctgccagc gcgtgagaga cggcacaagg 3420
atgagggccc cggagctggc cactcccgcc atacgccaca tcatgctgaa ctgctggtcc 3480
ggagacccca aggcgagacc tgcattctcg gacctggtgg agatcctggg ggacctgctc 3540
cagggcaggg gcctgcaaga ggaagaggag gtctgcatgg ccccgcgcag ctctcagagc 3600
tcagaagagg gcagcttctc gcaggtgtcc accatggccc tacacatcgc ccaggctgac 3660
gctgaggaca gcccgccaag cctgcagcgc cacagcctgg ccgccaggta ttacaactgg 3720
gtgtcctttc ccgggtgcct ggccagaggg gctgagaccc gtggttcctc caggatgaag 3780
acatttgagg aattccccat gaccccaacg acctacaaag gctctgtgga caaccagaca 3840
gacagtggga tggtgctggc ctcggaggag tttgagcaga tagagagcag gcatagacaa 3900
gaaagcggct tcaggtagct gaagcagaga gagagaaggc agcatacgtc agcattttct 3960
tctctgcact tataagaaag atcaaagact ttaagacttt cgctatttct tctactgcta 4020
tctactacaa acttcaaaga ggaaccagga ggacaagagg agcatgaaag tggacaagga 4080
gtgtgaccac tgaagcacca cagggagggg ttaggcctcc ggatgactgc gggcaggcct 4140
ggataatatc cagcctccca caagaagctg gtggagcaga gtgttccctg actcctccaa 4200
ggaaagggag acgccctttc atggtctgct gagtaacagg tgccttccca gacactggcg 4260
ttactgcttg accaaagagc cctcaagcgg cccttatgcc agcgtgacag agggctcacc 4320
tcttgccttc taggtcactt ctcacaatgt cccttcagca cctgaccctg tgcccgccga 4380
ttattccttg gtaatatgag taatacatca aagagtagta ttaaaagcta attaatcatg 4440
tttataaaaa                                                        4450


<210> 392
<211> 913
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP054699
<309> 2004-10-26  

<400> 392
Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala
 1               5                  10                  15      
Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg
            20                  25                  30          
Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser
        35                  40                  45              
Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu
    50                  55                  60                  
Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe
65                  70                  75                  80  
Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu
                85                  90                  95      
Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys
            100                 105                 110         
Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg
        115                 120                 125             
Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn
    130                 135                 140                 
Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val
145                 150                 155                 160 
Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val
                165                 170                 175     
Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu
            180                 185                 190         
Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val
        195                 200                 205             
Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln
    210                 215                 220                 
Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp
225                 230                 235                 240 
Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val
                245                 250                 255     
Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe
            260                 265                 270         
Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn
        275                 280                 285             
Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg
    290                 295                 300                 
Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His
305                 310                 315                 320 
Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val
                325                 330                 335     
Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe
            340                 345                 350         
Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val
        355                 360                 365             
Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro
    370                 375                 380                 
Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu
385                 390                 395                 400 
Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr
                405                 410                 415     
Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu
            420                 425                 430         
Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser
        435                 440                 445             
Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser
    450                 455                 460                 
Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu
465                 470                 475                 480 
Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser
                485                 490                 495     
Ala Pro Cys Val Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala
            500                 505                 510         
Tyr Arg Leu Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly Pro Gly
        515                 520                 525             
Pro Pro Thr Pro Ala Trp Ala Lys Pro Thr Asn Thr Gln Ala Tyr Ser
    530                 535                 540                 
Gly Asp Tyr Met Glu Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro
545                 550                 555                 560 
Pro Pro Gln Asn Ser Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr
                565                 570                 575     
Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro
            580                 585                 590         
Pro Gly Ala Val Gly Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser
        595                 600                 605             
Arg Leu Arg Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val
    610                 615                 620                 
His Leu Cys Glu Val Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe
625                 630                 635                 640 
Pro Leu Asn Val Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile
                645                 650                 655     
Leu Arg Pro Asp Ala Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu
            660                 665                 670         
Val Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu
        675                 680                 685             
Gly Val Cys Val Gln Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met
    690                 695                 700                 
Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp
705                 710                 715                 720 
Lys Ala Ala Glu Gly Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro
                725                 730                 735     
Thr Ile Ser Tyr Pro Met Leu Leu His Val Ala Ala Gln Ile Ala Ser
            740                 745                 750         
Gly Met Arg Tyr Leu Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala
        755                 760                 765             
Thr Arg Asn Cys Leu Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp
    770                 775                 780                 
Phe Gly Met Ser Arg Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln
785                 790                 795                 800 
Gly Arg Ala Val Leu Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu
                805                 810                 815     
Met Gly Lys Phe Thr Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr
            820                 825                 830         
Leu Trp Glu Val Leu Met Leu Cys Arg Ala Gln Pro Phe Gly Ser Ala
        835                 840                 845             
His Arg Arg Ala Gly His Arg Glu Arg Gly Gly Val Leu Pro Gly Pro
    850                 855                 860                 
Gly Pro Ala Val Tyr Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu
865                 870                 875                 880 
Tyr Glu Leu Met Leu Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro
                885                 890                 895     
Pro Phe Ser Gln Leu His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr
            900                 905                 910         
Val
    

<210> 393
<211> 855
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP006173
<309> 2004-10-26  

<400> 393
Met Ile Leu Ile Pro Arg Met Leu Leu Val Leu Phe Leu Leu Leu Pro
 1               5                  10                  15      
Ile Leu Ser Ser Ala Lys Ala Gln Val Asn Pro Ala Ile Cys Arg Tyr
            20                  25                  30          
Pro Leu Gly Met Ser Gly Gly Gln Ile Pro Asp Glu Asp Ile Thr Ala
        35                  40                  45              
Ser Ser Gln Trp Ser Glu Ser Thr Ala Ala Lys Tyr Gly Arg Leu Asp
    50                  55                  60                  
Ser Glu Glu Gly Asp Gly Ala Trp Cys Pro Glu Ile Pro Val Glu Pro
65                  70                  75                  80  
Asp Asp Leu Lys Glu Phe Leu Gln Ile Asp Leu His Thr Leu His Phe
                85                  90                  95      
Ile Thr Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly His Gly Ile
            100                 105                 110         
Glu Phe Ala Pro Met Tyr Lys Ile Asn Tyr Ser Arg Asp Gly Thr Arg
        115                 120                 125             
Trp Ile Ser Trp Arg Asn Arg His Gly Lys Gln Val Leu Asp Gly Asn
    130                 135                 140                 
Ser Asn Pro Tyr Asp Ile Phe Leu Lys Asp Leu Glu Pro Pro Ile Val
145                 150                 155                 160 
Ala Arg Phe Val Arg Phe Ile Pro Val Thr Asp His Ser Met Asn Val
                165                 170                 175     
Cys Met Arg Val Glu Leu Tyr Gly Cys Val Trp Leu Asp Gly Leu Val
            180                 185                 190         
Ser Tyr Asn Ala Pro Ala Gly Gln Gln Phe Val Leu Pro Gly Gly Ser
        195                 200                 205             
Ile Ile Tyr Leu Asn Asp Ser Val Tyr Asp Gly Ala Val Gly Tyr Ser
    210                 215                 220                 
Met Thr Glu Gly Leu Gly Gln Leu Thr Asp Gly Val Ser Gly Leu Asp
225                 230                 235                 240 
Asp Phe Thr Gln Thr His Glu Tyr His Val Trp Pro Gly Tyr Asp Tyr
                245                 250                 255     
Val Gly Trp Arg Asn Glu Ser Ala Thr Asn Gly Tyr Ile Glu Ile Met
            260                 265                 270         
Phe Glu Phe Asp Arg Ile Arg Asn Phe Thr Thr Met Lys Val His Cys
        275                 280                 285             
Asn Asn Met Phe Ala Lys Gly Val Lys Ile Phe Lys Glu Val Gln Cys
    290                 295                 300                 
Tyr Phe Arg Ser Glu Ala Ser Glu Trp Glu Pro Asn Ala Ile Ser Phe
305                 310                 315                 320 
Pro Leu Val Leu Asp Asp Val Asn Pro Ser Ala Arg Phe Val Thr Val
                325                 330                 335     
Pro Leu His His Arg Met Ala Ser Ala Ile Lys Cys Gln Tyr His Phe
            340                 345                 350         
Ala Asp Thr Trp Met Met Phe Ser Glu Ile Thr Phe Gln Ser Asp Ala
        355                 360                 365             
Ala Met Tyr Asn Asn Ser Glu Ala Leu Pro Thr Ser Pro Met Ala Pro
    370                 375                 380                 
Thr Thr Tyr Asp Pro Met Leu Lys Val Asp Asp Ser Asn Thr Arg Ile
385                 390                 395                 400 
Leu Ile Gly Cys Leu Val Ala Ile Ile Phe Ile Leu Leu Ala Ile Ile
                405                 410                 415     
Val Ile Ile Leu Trp Arg Gln Phe Trp Gln Lys Met Leu Glu Lys Ala
            420                 425                 430         
Ser Arg Arg Met Leu Asp Asp Glu Met Thr Val Ser Leu Ser Leu Pro
        435                 440                 445             
Ser Asp Ser Ser Met Phe Asn Asn Asn Arg Ser Ser Ser Pro Ser Glu
    450                 455                 460                 
Gln Gly Ser Asn Ser Thr Tyr Asp Arg Ile Phe Pro Leu Arg Pro Asp
465                 470                 475                 480 
Tyr Gln Glu Pro Ser Arg Leu Ile Arg Lys Leu Pro Glu Phe Ala Pro
                485                 490                 495     
Gly Glu Glu Glu Ser Gly Cys Ser Gly Val Val Lys Pro Val Gln Pro
            500                 505                 510         
Ser Gly Pro Glu Gly Val Pro His Tyr Ala Glu Ala Asp Ile Val Asn
        515                 520                 525             
Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ser Val Pro Ala Val Thr
    530                 535                 540                 
Met Asp Leu Leu Ser Gly Lys Asp Val Ala Val Glu Glu Phe Pro Arg
545                 550                 555                 560 
Lys Leu Leu Thr Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu
                565                 570                 575     
Val His Leu Cys Glu Val Glu Gly Met Glu Lys Phe Lys Asp Lys Asp
            580                 585                 590         
Phe Ala Leu Asp Val Ser Ala Asn Gln Pro Val Leu Val Ala Val Lys
        595                 600                 605             
Met Leu Arg Ala Asp Ala Asn Lys Asn Ala Arg Asn Asp Phe Leu Lys
    610                 615                 620                 
Glu Ile Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile His Leu
625                 630                 635                 640 
Leu Ser Val Cys Ile Thr Asp Asp Pro Leu Cys Met Ile Thr Glu Tyr
                645                 650                 655     
Met Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Arg His Glu Pro Pro
            660                 665                 670         
Asn Ser Ser Ser Ser Asp Val Arg Thr Val Ser Tyr Thr Asn Leu Lys
        675                 680                 685             
Phe Met Ala Thr Gln Ile Ala Ser Gly Met Lys Tyr Leu Ser Ser Leu
    690                 695                 700                 
Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Lys
705                 710                 715                 720 
Asn Tyr Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg Asn Leu Tyr
                725                 730                 735     
Ser Gly Asp Tyr Tyr Arg Ile Gln Gly Arg Ala Val Leu Pro Ile Arg
            740                 745                 750         
Trp Met Ser Trp Glu Ser Ile Leu Leu Gly Lys Phe Thr Thr Ala Ser
        755                 760                 765             
Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Thr Phe Thr Phe Cys
    770                 775                 780                 
Gln Glu Gln Pro Tyr Ser Gln Leu Ser Asp Glu Gln Val Ile Glu Asn
785                 790                 795                 800 
Thr Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Thr Tyr Leu Pro Gln
                805                 810                 815     
Pro Ala Ile Cys Pro Asp Ser Val Tyr Lys Leu Met Leu Ser Cys Trp
            820                 825                 830         
Arg Arg Asp Thr Lys Asn Arg Pro Ser Phe Gln Glu Ile His Leu Leu
        835                 840                 845             
Leu Leu Gln Gln Gly Asp Glu
    850                 855 

<210> 394
<211> 976
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP005223
<309> 2004-11-29  

<400> 394
Met Glu Arg Arg Trp Pro Leu Gly Leu Gly Leu Val Leu Leu Leu Cys
 1               5                  10                  15      
Ala Pro Leu Pro Pro Gly Ala Arg Ala Lys Glu Val Thr Leu Met Asp
            20                  25                  30          
Thr Ser Lys Ala Gln Gly Glu Leu Gly Trp Leu Leu Asp Pro Pro Lys
        35                  40                  45              
Asp Gly Trp Ser Glu Gln Gln Gln Ile Leu Asn Gly Thr Pro Leu Tyr
    50                  55                  60                  
Met Tyr Gln Asp Cys Pro Met Gln Gly Arg Arg Asp Thr Asp His Trp
65                  70                  75                  80  
Leu Arg Ser Asn Trp Ile Tyr Arg Gly Glu Glu Ala Ser Arg Val His
                85                  90                  95      
Val Glu Leu Gln Phe Thr Val Arg Asp Cys Lys Ser Phe Pro Gly Gly
            100                 105                 110         
Ala Gly Pro Leu Gly Cys Lys Glu Thr Phe Asn Leu Leu Tyr Met Glu
        115                 120                 125             
Ser Asp Gln Asp Val Gly Ile Gln Leu Arg Arg Pro Leu Phe Gln Lys
    130                 135                 140                 
Val Thr Thr Val Ala Ala Asp Gln Ser Phe Thr Ile Arg Asp Leu Ala
145                 150                 155                 160 
Ser Gly Ser Val Lys Leu Asn Val Glu Arg Cys Ser Leu Gly Arg Leu
                165                 170                 175     
Thr Arg Arg Gly Leu Tyr Leu Ala Phe His Asn Pro Gly Ala Cys Val
            180                 185                 190         
Ala Leu Val Ser Val Arg Val Phe Tyr Gln Arg Cys Pro Glu Thr Leu
        195                 200                 205             
Asn Gly Leu Ala Gln Phe Pro Asp Thr Leu Pro Gly Pro Ala Gly Leu
    210                 215                 220                 
Val Glu Val Ala Gly Thr Cys Leu Pro His Ala Arg Ala Ser Pro Arg
225                 230                 235                 240 
Pro Ser Gly Ala Pro Arg Met His Cys Ser Pro Asp Gly Glu Trp Leu
                245                 250                 255     
Val Pro Val Gly Arg Cys His Cys Glu Pro Gly Tyr Glu Glu Gly Gly
            260                 265                 270         
Ser Gly Glu Ala Cys Val Ala Cys Pro Ser Gly Ser Tyr Arg Met Asp
        275                 280                 285             
Met Asp Thr Pro His Cys Leu Thr Cys Pro Gln Gln Ser Thr Ala Glu
    290                 295                 300                 
Ser Glu Gly Ala Thr Ile Cys Thr Cys Glu Ser Gly His Tyr Arg Ala
305                 310                 315                 320 
Pro Gly Glu Gly Pro Gln Val Ala Cys Thr Gly Pro Pro Ser Ala Pro
                325                 330                 335     
Arg Asn Leu Ser Phe Ser Ala Ser Gly Thr Gln Leu Ser Leu Arg Trp
            340                 345                 350         
Glu Pro Pro Ala Asp Thr Gly Gly Arg Gln Asp Val Arg Tyr Ser Val
        355                 360                 365             
Arg Cys Ser Gln Cys Gln Gly Thr Ala Gln Asp Gly Gly Pro Cys Gln
    370                 375                 380                 
Pro Cys Gly Val Gly Val His Phe Ser Pro Gly Ala Arg Gly Leu Thr
385                 390                 395                 400 
Thr Pro Ala Val His Val Asn Gly Leu Glu Pro Tyr Ala Asn Tyr Thr
                405                 410                 415     
Phe Asn Val Glu Ala Gln Asn Gly Val Ser Gly Leu Gly Ser Ser Gly
            420                 425                 430         
His Ala Ser Thr Ser Val Ser Ile Ser Met Gly His Ala Glu Ser Leu
        435                 440                 445             
Ser Gly Leu Ser Leu Arg Leu Val Lys Lys Glu Pro Arg Gln Leu Glu
    450                 455                 460                 
Leu Thr Trp Ala Gly Ser Arg Pro Arg Ser Pro Gly Ala Asn Leu Thr
465                 470                 475                 480 
Tyr Glu Leu His Val Leu Asn Gln Asp Glu Glu Arg Tyr Gln Met Val
                485                 490                 495     
Leu Glu Pro Arg Val Leu Leu Thr Glu Leu Gln Pro Asp Thr Thr Tyr
            500                 505                 510         
Ile Val Arg Val Arg Met Leu Thr Pro Leu Gly Pro Gly Pro Phe Ser
        515                 520                 525             
Pro Asp His Glu Phe Arg Thr Ser Pro Pro Val Ser Arg Gly Leu Thr
    530                 535                 540                 
Gly Gly Glu Ile Val Ala Val Ile Phe Gly Leu Leu Leu Gly Ala Ala
545                 550                 555                 560 
Leu Leu Leu Gly Ile Leu Val Phe Arg Ser Arg Arg Ala Gln Arg Gln
                565                 570                 575     
Arg Gln Gln Arg Gln Arg Asp Arg Ala Thr Asp Val Asp Arg Glu Asp
            580                 585                 590         
Lys Leu Trp Leu Lys Pro Tyr Val Asp Leu Gln Ala Tyr Glu Asp Pro
        595                 600                 605             
Ala Gln Gly Ala Leu Asp Phe Thr Arg Glu Leu Asp Pro Ala Trp Leu
    610                 615                 620                 
Met Val Asp Thr Val Ile Gly Glu Gly Glu Phe Gly Glu Val Tyr Arg
625                 630                 635                 640 
Gly Thr Leu Arg Leu Pro Ser Gln Asp Cys Lys Thr Val Ala Ile Lys
                645                 650                 655     
Thr Leu Lys Asp Thr Ser Pro Gly Gly Gln Trp Trp Asn Phe Leu Arg
            660                 665                 670         
Glu Ala Thr Ile Met Gly Gln Phe Ser His Pro His Ile Leu His Leu
        675                 680                 685             
Glu Gly Val Val Thr Lys Arg Lys Pro Ile Met Ile Ile Thr Glu Phe
    690                 695                 700                 
Met Glu Asn Gly Ala Leu Asp Ala Phe Leu Arg Glu Arg Glu Asp Gln
705                 710                 715                 720 
Leu Val Pro Gly Gln Leu Val Ala Met Leu Gln Gly Ile Ala Ser Gly
                725                 730                 735     
Met Asn Tyr Leu Ser Asn His Asn Tyr Val His Arg Asp Leu Ala Ala
            740                 745                 750         
Arg Asn Ile Leu Val Asn Gln Asn Leu Cys Cys Lys Val Ser Asp Phe
        755                 760                 765             
Gly Leu Thr Arg Leu Leu Asp Asp Phe Asp Gly Thr Tyr Glu Thr Gln
    770                 775                 780                 
Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala His
785                 790                 795                 800 
Arg Ile Phe Thr Thr Ala Ser Asp Val Trp Ser Phe Gly Ile Val Met
                805                 810                 815     
Trp Glu Val Leu Ser Phe Gly Asp Lys Pro Tyr Gly Glu Met Ser Asn
            820                 825                 830         
Gln Glu Val Met Lys Ser Ile Glu Asp Gly Tyr Arg Leu Pro Pro Pro
        835                 840                 845             
Val Asp Cys Pro Ala Pro Leu Tyr Glu Leu Met Lys Asn Cys Trp Ala
    850                 855                 860                 
Tyr Asp Arg Ala Arg Arg Pro His Phe Gln Lys Leu Gln Ala His Leu
865                 870                 875                 880 
Glu Gln Leu Leu Ala Asn Pro His Ser Leu Arg Thr Ile Ala Asn Phe
                885                 890                 895     
Asp Pro Arg Met Thr Leu Arg Leu Pro Ser Leu Ser Gly Ser Asp Gly
            900                 905                 910         
Ile Pro Tyr Arg Thr Val Ser Glu Trp Leu Glu Ser Ile Arg Met Lys
        915                 920                 925             
Arg Tyr Ile Leu His Phe His Ser Ala Gly Leu Asp Thr Met Glu Cys
    930                 935                 940                 
Val Leu Glu Leu Thr Ala Glu Asp Leu Thr Gln Met Gly Ile Thr Leu
945                 950                 955                 960 
Pro Gly His Gln Lys Arg Ile Leu Cys Ser Ile Gln Gly Phe Lys Asp
                965                 970                 975     


<210> 395
<211> 976
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP004422
<309> 2004-12-20  

<400> 395
Met Glu Leu Gln Ala Ala Arg Ala Cys Phe Ala Leu Leu Trp Gly Cys
 1               5                  10                  15      
Ala Leu Ala Ala Ala Ala Ala Ala Gln Gly Lys Glu Val Val Leu Leu
            20                  25                  30          
Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly Trp Leu Thr His Pro Tyr
        35                  40                  45              
Gly Lys Gly Trp Asp Leu Met Gln Asn Ile Met Asn Asp Met Pro Ile
    50                  55                  60                  
Tyr Met Tyr Ser Val Cys Asn Val Met Ser Gly Asp Gln Asp Asn Trp
65                  70                  75                  80  
Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu Ala Glu Arg Ile Phe Ile
                85                  90                  95      
Glu Leu Lys Phe Thr Val Arg Asp Cys Asn Ser Phe Pro Gly Gly Ala
            100                 105                 110         
Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Ala Glu Ser Asp Leu
        115                 120                 125             
Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu Phe Thr Lys Ile Asp Thr
    130                 135                 140                 
Ile Ala Pro Asp Glu Ile Thr Val Ser Ser Asp Phe Glu Ala Arg His
145                 150                 155                 160 
Val Lys Leu Asn Val Glu Glu Arg Ser Val Gly Pro Leu Thr Arg Lys
                165                 170                 175     
Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Val Ala Leu Leu
            180                 185                 190         
Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Glu Leu Leu Gln Gly Leu
        195                 200                 205             
Ala His Phe Pro Glu Thr Ile Ala Gly Ser Asp Ala Pro Ser Leu Ala
    210                 215                 220                 
Thr Val Ala Gly Thr Cys Val Asp His Ala Val Val Pro Pro Gly Gly
225                 230                 235                 240 
Glu Glu Pro Arg Met His Cys Ala Val Asp Gly Glu Trp Leu Val Pro
                245                 250                 255     
Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr Glu Lys Val Glu Asp Ala
            260                 265                 270         
Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys Phe Glu Ala Ser Glu Ser
        275                 280                 285             
Pro Cys Leu Glu Cys Pro Glu His Thr Leu Pro Ser Pro Glu Gly Ala
    290                 295                 300                 
Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe Arg Ala Pro Gln Asp Pro
305                 310                 315                 320 
Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro His Tyr Leu Thr
                325                 330                 335     
Ala Val Gly Met Gly Ala Lys Val Glu Leu Arg Trp Thr Pro Pro Gln
            340                 345                 350         
Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr Ser Val Thr Cys Glu Gln
        355                 360                 365             
Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro Cys Glu Ala Ser Val Arg
    370                 375                 380                 
Tyr Ser Glu Pro Pro His Gly Leu Thr Arg Thr Ser Val Thr Val Ser
385                 390                 395                 400 
Asp Leu Glu Pro His Met Asn Tyr Thr Phe Thr Val Glu Ala Arg Asn
                405                 410                 415     
Gly Val Ser Gly Leu Val Thr Ser Arg Ser Phe Arg Thr Ala Ser Val
            420                 425                 430         
Ser Ile Asn Gln Thr Glu Pro Pro Lys Val Arg Leu Glu Gly Arg Ser
        435                 440                 445             
Thr Thr Ser Leu Ser Val Ser Trp Ser Ile Pro Pro Pro Gln Gln Ser
    450                 455                 460                 
Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg Lys Lys Gly Asp Ser Asn
465                 470                 475                 480 
Ser Tyr Asn Val Arg Arg Thr Glu Gly Phe Ser Val Thr Leu Asp Asp
                485                 490                 495     
Leu Ala Pro Asp Thr Thr Tyr Leu Val Gln Val Gln Ala Leu Thr Gln
            500                 505                 510         
Glu Gly Gln Gly Ala Gly Ser Lys Val His Glu Phe Gln Thr Leu Ser
        515                 520                 525             
Pro Glu Gly Ser Gly Asn Leu Ala Val Ile Gly Gly Val Ala Val Gly
    530                 535                 540                 
Val Val Leu Leu Leu Val Leu Ala Gly Val Gly Phe Phe Ile His Arg
545                 550                 555                 560 
Arg Arg Lys Asn Gln Arg Ala Arg Gln Ser Pro Glu Asp Val Tyr Phe
                565                 570                 575     
Ser Lys Ser Glu Gln Leu Lys Pro Leu Lys Thr Tyr Val Asp Pro His
            580                 585                 590         
Thr Tyr Glu Asp Pro Asn Gln Ala Val Leu Lys Phe Thr Thr Glu Ile
        595                 600                 605             
His Pro Ser Cys Val Thr Arg Gln Lys Val Ile Gly Ala Gly Glu Phe
    610                 615                 620                 
Gly Glu Val Tyr Lys Gly Met Leu Lys Thr Ser Ser Gly Lys Lys Glu
625                 630                 635                 640 
Val Pro Val Ala Ile Lys Thr Leu Lys Ala Gly Tyr Thr Glu Lys Gln
                645                 650                 655     
Arg Val Asp Phe Leu Gly Glu Ala Gly Ile Met Gly Gln Phe Ser His
            660                 665                 670         
His Asn Ile Ile Arg Leu Glu Gly Val Ile Ser Lys Tyr Lys Pro Met
        675                 680                 685             
Met Ile Ile Thr Glu Tyr Met Glu Asn Gly Ala Leu Asp Lys Phe Leu
    690                 695                 700                 
Arg Glu Lys Asp Gly Glu Phe Ser Val Leu Gln Leu Val Gly Met Leu
705                 710                 715                 720 
Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Asn Met Asn Tyr Val
                725                 730                 735     
His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val
            740                 745                 750         
Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro
        755                 760                 765             
Glu Ala Thr Tyr Thr Thr Ser Gly Gly Lys Ile Pro Ile Arg Trp Thr
    770                 775                 780                 
Ala Pro Glu Ala Ile Ser Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val
785                 790                 795                 800 
Trp Ser Phe Gly Ile Val Met Trp Glu Val Met Thr Tyr Gly Glu Arg
                805                 810                 815     
Pro Tyr Trp Glu Leu Ser Asn His Glu Val Met Lys Ala Ile Asn Asp
            820                 825                 830         
Gly Phe Arg Leu Pro Thr Pro Met Asp Cys Pro Ser Ala Ile Tyr Gln
        835                 840                 845             
Leu Met Met Gln Cys Trp Gln Gln Glu Arg Ala Arg Arg Pro Lys Phe
    850                 855                 860                 
Ala Asp Ile Val Ser Ile Leu Asp Lys Leu Ile Arg Ala Pro Asp Ser
865                 870                 875                 880 
Leu Lys Thr Leu Ala Asp Phe Asp Pro Arg Val Ser Ile Arg Leu Pro
                885                 890                 895     
Ser Thr Ser Gly Ser Glu Gly Val Pro Phe Arg Thr Val Ser Glu Trp
            900                 905                 910         
Leu Glu Ser Ile Lys Met Gln Gln Tyr Thr Glu His Phe Met Ala Ala
        915                 920                 925             
Gly Tyr Thr Ala Ile Glu Lys Val Val Gln Met Thr Asn Asp Asp Ile
    930                 935                 940                 
Lys Arg Ile Gly Val Arg Leu Pro Gly His Gln Lys Arg Ile Ala Tyr
945                 950                 955                 960 
Ser Leu Leu Gly Leu Lys Asp Gln Val Asn Thr Val Gly Ile Pro Ile
                965                 970                 975     


<210> 396
<211> 983
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP005224
<309> 2004-11-16  

<400> 396
Met Asp Cys Gln Leu Ser Ile Leu Leu Leu Leu Ser Cys Ser Val Leu
 1               5                  10                  15      
Asp Ser Phe Gly Glu Leu Ile Pro Gln Pro Ser Asn Glu Val Asn Leu
            20                  25                  30          
Leu Asp Ser Lys Thr Ile Gln Gly Glu Leu Gly Trp Ile Ser Tyr Pro
        35                  40                  45              
Ser His Gly Trp Glu Glu Ile Ser Gly Val Asp Glu His Tyr Thr Pro
    50                  55                  60                  
Ile Arg Thr Tyr Gln Val Cys Asn Val Met Asp His Ser Gln Asn Asn
65                  70                  75                  80  
Trp Leu Arg Thr Asn Trp Val Pro Arg Asn Ser Ala Gln Lys Ile Tyr
                85                  90                  95      
Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Ile Pro Leu Val
            100                 105                 110         
Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Met Glu Ser Asp
        115                 120                 125             
Asp Asp His Gly Val Lys Phe Arg Glu His Gln Phe Thr Lys Ile Asp
    130                 135                 140                 
Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Met Asp Leu Gly Asp Arg
145                 150                 155                 160 
Ile Leu Lys Leu Asn Thr Glu Ile Arg Glu Val Gly Pro Val Asn Lys
                165                 170                 175     
Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Val Ala Leu
            180                 185                 190         
Val Ser Val Arg Val Tyr Phe Lys Lys Cys Pro Phe Thr Val Lys Asn
        195                 200                 205             
Leu Ala Met Phe Pro Asp Thr Val Pro Met Asp Ser Gln Ser Leu Val
    210                 215                 220                 
Glu Val Arg Gly Ser Cys Val Asn Asn Ser Lys Glu Glu Asp Pro Pro
225                 230                 235                 240 
Arg Met Tyr Cys Ser Thr Glu Gly Glu Trp Leu Val Pro Ile Gly Lys
                245                 250                 255     
Cys Ser Cys Asn Ala Gly Tyr Glu Glu Arg Gly Phe Met Cys Gln Ala
            260                 265                 270         
Cys Arg Pro Gly Phe Tyr Lys Ala Leu Asp Gly Asn Met Lys Cys Ala
        275                 280                 285             
Lys Cys Pro Pro His Ser Ser Thr Gln Glu Asp Gly Ser Met Asn Cys
    290                 295                 300                 
Arg Cys Glu Asn Asn Tyr Phe Arg Ala Asp Lys Asp Pro Pro Ser Met
305                 310                 315                 320 
Ala Cys Thr Arg Pro Pro Ser Ser Pro Arg Asn Val Ile Ser Asn Ile
                325                 330                 335     
Asn Glu Thr Ser Val Ile Leu Asp Trp Ser Trp Pro Leu Asp Thr Gly
            340                 345                 350         
Gly Arg Lys Asp Val Thr Phe Asn Ile Ile Cys Lys Lys Cys Gly Trp
        355                 360                 365             
Asn Ile Lys Gln Cys Glu Pro Cys Ser Pro Asn Val Arg Phe Leu Pro
    370                 375                 380                 
Arg Gln Phe Gly Leu Thr Asn Thr Thr Val Thr Val Thr Asp Leu Leu
385                 390                 395                 400 
Ala His Thr Asn Tyr Thr Phe Glu Ile Asp Ala Val Asn Gly Val Ser
                405                 410                 415     
Glu Leu Ser Ser Pro Pro Arg Gln Phe Ala Ala Val Ser Ile Thr Thr
            420                 425                 430         
Asn Gln Ala Ala Pro Ser Pro Val Leu Thr Ile Lys Lys Asp Arg Thr
        435                 440                 445             
Ser Arg Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Glu His Pro Asn
    450                 455                 460                 
Gly Ile Ile Leu Asp Tyr Glu Val Lys Tyr Tyr Glu Lys Gln Glu Gln
465                 470                 475                 480 
Glu Thr Ser Tyr Thr Ile Leu Arg Ala Arg Gly Thr Asn Val Thr Ile
                485                 490                 495     
Ser Ser Leu Lys Pro Asp Thr Ile Tyr Val Phe Gln Ile Arg Ala Arg
            500                 505                 510         
Thr Ala Ala Gly Tyr Gly Thr Asn Ser Arg Lys Phe Glu Phe Glu Thr
        515                 520                 525             
Ser Pro Asp Ser Phe Ser Ile Ser Gly Glu Ser Ser Gln Val Val Met
    530                 535                 540                 
Ile Ala Ile Ser Ala Ala Val Ala Ile Ile Leu Leu Thr Val Val Ile
545                 550                 555                 560 
Tyr Val Leu Ile Gly Arg Phe Cys Gly Tyr Lys Ser Lys His Gly Ala
                565                 570                 575     
Asp Glu Lys Arg Leu His Phe Gly Asn Gly His Leu Lys Leu Pro Gly
            580                 585                 590         
Leu Arg Thr Tyr Val Asp Pro His Thr Tyr Glu Asp Pro Thr Gln Ala
        595                 600                 605             
Val His Glu Phe Ala Lys Glu Leu Asp Ala Thr Asn Ile Ser Ile Asp
    610                 615                 620                 
Lys Val Val Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu
625                 630                 635                 640 
Lys Leu Pro Ser Lys Lys Glu Ile Ser Val Ala Ile Lys Thr Leu Lys
                645                 650                 655     
Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Gly Glu Ala Ser
            660                 665                 670         
Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val
        675                 680                 685             
Val Thr Lys Ser Lys Pro Val Met Ile Val Thr Glu Tyr Met Glu Asn
    690                 695                 700                 
Gly Ser Leu Asp Ser Phe Leu Arg Lys His Asp Ala Gln Phe Thr Val
705                 710                 715                 720 
Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ser Gly Met Lys Tyr
                725                 730                 735     
Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile
            740                 745                 750         
Leu Ile Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser
        755                 760                 765             
Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly
    770                 775                 780                 
Lys Ile Pro Ile Arg Trp Thr Ser Pro Glu Ala Ile Ala Tyr Arg Lys
785                 790                 795                 800 
Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Leu Trp Glu
                805                 810                 815     
Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Glu Met Ser Asn Gln Asp
            820                 825                 830         
Val Ile Lys Ala Val Asp Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp
        835                 840                 845             
Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu Asp Cys Trp Gln Lys Asp
    850                 855                 860                 
Arg Asn Asn Arg Pro Lys Phe Glu Gln Ile Val Ser Ile Leu Asp Lys
865                 870                 875                 880 
Leu Ile Arg Asn Pro Gly Ser Leu Lys Ile Ile Thr Ser Ala Ala Ala
                885                 890                 895     
Arg Pro Ser Asn Leu Leu Leu Asp Gln Ser Asn Val Asp Ile Thr Thr
            900                 905                 910         
Phe Arg Thr Thr Gly Asp Trp Leu Asn Gly Val Trp Thr Ala His Cys
        915                 920                 925             
Lys Glu Ile Phe Thr Gly Val Glu Tyr Ser Ser Cys Asp Thr Ile Ala
    930                 935                 940                 
Lys Ile Ser Thr Asp Asp Met Lys Lys Val Gly Val Thr Val Val Gly
945                 950                 955                 960 
Pro Gln Lys Lys Ile Ile Ser Ser Ile Lys Ala Leu Glu Thr Gln Ser
                965                 970                 975     
Lys Asn Gly Pro Val Pro Val
            980             


<210> 397
<211> 986
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP004429
<309> 2004-11-16  

<400> 397
Met Ala Gly Ile Phe Tyr Phe Ala Leu Phe Ser Cys Leu Phe Gly Ile
 1               5                  10                  15      
Cys Asp Ala Val Thr Gly Ser Arg Val Tyr Pro Ala Asn Glu Val Thr
            20                  25                  30          
Leu Leu Asp Ser Arg Ser Val Gln Gly Glu Leu Gly Trp Ile Ala Ser
        35                  40                  45              
Pro Leu Glu Gly Gly Trp Glu Glu Val Ser Ile Met Asp Glu Lys Asn
    50                  55                  60                  
Thr Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Met Glu Pro Ser Gln
65                  70                  75                  80  
Asn Asn Trp Leu Arg Thr Asp Trp Ile Thr Arg Glu Gly Ala Gln Arg
                85                  90                  95      
Val Tyr Ile Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro
            100                 105                 110         
Gly Val Met Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu
        115                 120                 125             
Ser Asp Asn Asp Lys Glu Arg Phe Ile Arg Glu Asn Gln Phe Val Lys
    130                 135                 140                 
Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Val Asp Ile Gly
145                 150                 155                 160 
Asp Arg Ile Met Lys Leu Asn Thr Glu Ile Arg Asp Val Gly Pro Leu
                165                 170                 175     
Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile
            180                 185                 190         
Ala Leu Val Ser Val Arg Val Phe Tyr Lys Lys Cys Pro Leu Thr Val
        195                 200                 205             
Arg Asn Leu Ala Gln Phe Pro Asp Thr Ile Thr Gly Ala Asp Thr Ser
    210                 215                 220                 
Ser Leu Val Glu Val Arg Gly Ser Cys Val Asn Asn Ser Glu Glu Lys
225                 230                 235                 240 
Asp Val Pro Lys Met Tyr Cys Gly Ala Asp Gly Glu Trp Leu Val Pro
                245                 250                 255     
Ile Gly Asn Cys Leu Cys Asn Ala Gly His Glu Glu Arg Ser Gly Glu
            260                 265                 270         
Cys Gln Ala Cys Lys Ile Gly Tyr Tyr Lys Ala Leu Ser Thr Asp Ala
        275                 280                 285             
Thr Cys Ala Lys Cys Pro Pro His Ser Tyr Ser Val Trp Glu Gly Ala
    290                 295                 300                 
Thr Ser Cys Thr Cys Asp Arg Gly Phe Phe Arg Ala Asp Asn Asp Ala
305                 310                 315                 320 
Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro Leu Asn Leu Ile
                325                 330                 335     
Ser Asn Val Asn Glu Thr Ser Val Asn Leu Glu Trp Ser Ser Pro Gln
            340                 345                 350         
Asn Thr Gly Gly Arg Gln Asp Ile Ser Tyr Asn Val Val Cys Lys Lys
        355                 360                 365             
Cys Gly Ala Gly Asp Pro Ser Lys Cys Arg Pro Cys Gly Ser Gly Val
    370                 375                 380                 
His Tyr Thr Pro Gln Gln Asn Gly Leu Lys Thr Thr Lys Val Ser Ile
385                 390                 395                 400 
Thr Asp Leu Leu Ala His Thr Asn Tyr Thr Phe Glu Ile Trp Ala Val
                405                 410                 415     
Asn Gly Val Ser Lys Tyr Asn Pro Asn Pro Asp Gln Ser Val Ser Val
            420                 425                 430         
Thr Val Thr Thr Asn Gln Ala Ala Pro Ser Ser Ile Ala Leu Val Gln
        435                 440                 445             
Ala Lys Glu Val Thr Arg Tyr Ser Val Ala Leu Ala Trp Leu Glu Pro
    450                 455                 460                 
Asp Arg Pro Asn Gly Val Ile Leu Glu Tyr Glu Val Lys Tyr Tyr Glu
465                 470                 475                 480 
Lys Asp Gln Asn Glu Arg Ser Tyr Arg Ile Val Arg Thr Ala Ala Arg
                485                 490                 495     
Asn Thr Asp Ile Lys Gly Leu Asn Pro Leu Thr Ser Tyr Val Phe His
            500                 505                 510         
Val Arg Ala Arg Thr Ala Ala Gly Tyr Gly Asp Phe Ser Glu Pro Leu
        515                 520                 525             
Glu Val Thr Thr Asn Thr Val Pro Ser Arg Ile Ile Gly Asp Gly Ala
    530                 535                 540                 
Asn Ser Thr Val Leu Leu Val Ser Val Ser Gly Ser Val Val Leu Val
545                 550                 555                 560 
Val Ile Leu Ile Ala Ala Phe Val Ile Ser Arg Arg Arg Ser Lys Tyr
                565                 570                 575     
Ser Lys Ala Lys Gln Glu Ala Asp Glu Glu Lys His Leu Asn Gln Gly
            580                 585                 590         
Val Arg Thr Tyr Val Asp Pro Phe Thr Tyr Glu Asp Pro Asn Gln Ala
        595                 600                 605             
Val Arg Glu Phe Ala Lys Glu Ile Asp Ala Ser Cys Ile Lys Ile Glu
    610                 615                 620                 
Lys Val Ile Gly Val Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu
625                 630                 635                 640 
Lys Val Pro Gly Lys Arg Glu Ile Cys Val Ala Ile Lys Thr Leu Lys
                645                 650                 655     
Ala Gly Tyr Thr Asp Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser
            660                 665                 670         
Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile His Leu Glu Gly Val
        675                 680                 685             
Val Thr Lys Cys Lys Pro Val Met Ile Ile Thr Glu Tyr Met Glu Asn
    690                 695                 700                 
Gly Ser Leu Asp Ala Phe Leu Arg Lys Asn Asp Gly Arg Phe Thr Val
705                 710                 715                 720 
Ile Gln Leu Val Gly Met Leu Arg Gly Ile Gly Ser Gly Met Lys Tyr
                725                 730                 735     
Leu Ser Asp Met Ser Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile
            740                 745                 750         
Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Met Ser
        755                 760                 765             
Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly
    770                 775                 780                 
Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys
785                 790                 795                 800 
Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu
                805                 810                 815     
Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp
            820                 825                 830         
Val Ile Lys Ala Ile Glu Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp
        835                 840                 845             
Cys Pro Ile Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu
    850                 855                 860                 
Arg Ser Asp Arg Pro Lys Phe Gly Gln Ile Val Asn Met Leu Asp Lys
865                 870                 875                 880 
Leu Ile Arg Asn Pro Asn Ser Leu Lys Arg Thr Gly Thr Glu Ser Ser
                885                 890                 895     
Arg Pro Asn Thr Ala Leu Leu Asp Pro Ser Ser Pro Glu Phe Ser Ala
            900                 905                 910         
Val Val Ser Val Gly Asp Trp Leu Gln Ala Ile Lys Met Asp Arg Tyr
        915                 920                 925             
Lys Asp Asn Phe Thr Ala Ala Gly Tyr Thr Thr Leu Glu Ala Val Val
    930                 935                 940                 
His Val Asn Gln Glu Asp Leu Ala Arg Ile Gly Ile Thr Ala Ile Thr
945                 950                 955                 960 
His Gln Asn Lys Ile Leu Ser Ser Val Gln Ala Met Arg Thr Gln Met
                965                 970                 975     
Gln Gln Met His Gly Arg Met Val Pro Val
            980                 985     


<210> 398
<211> 991
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. AAA74245
<309> 1995-08-10  

<400> 398
Pro Ala Ser Leu Ala Gly Cys Tyr Ser Ala Pro Arg Arg Ala Pro Leu
 1               5                  10                  15      
Trp Thr Cys Leu Leu Leu Cys Ala Ala Leu Arg Thr Leu Leu Ala Ser
            20                  25                  30          
Pro Ser Asn Glu Val Asn Leu Leu Asp Ser Arg Thr Val Met Gly Asp
        35                  40                  45              
Leu Gly Trp Ile Ala Phe Pro Lys Asn Gly Trp Glu Glu Ile Gly Glu
    50                  55                  60                  
Val Asp Glu Asn Tyr Ala Pro Ile His Thr Tyr Gln Val Cys Lys Val
65                  70                  75                  80  
Met Glu Gln Asn Gln Asn Asn Trp Leu Leu Thr Ser Trp Ile Ser Asn
                85                  90                  95      
Glu Gly Ala Ser Arg Ile Phe Ile Glu Leu Lys Phe Thr Leu Arg Asp
            100                 105                 110         
Cys Asn Ser Leu Pro Gly Gly Leu Gly Thr Cys Lys Glu Thr Phe Asn
        115                 120                 125             
Met Tyr Tyr Phe Glu Ser Asp Asp Gln Asn Gly Arg Asn Ile Lys Glu
    130                 135                 140                 
Asn Gln Tyr Ile Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr
145                 150                 155                 160 
Glu Leu Asp Leu Gly Asp Arg Val Met Lys Leu Asn Thr Glu Val Arg
                165                 170                 175     
Asp Val Gly Pro Leu Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp
            180                 185                 190         
Val Gly Ala Cys Ile Ala Leu Val Ser Val Arg Val Tyr Tyr Lys Lys
        195                 200                 205             
Cys Pro Ser Val Val Arg His Leu Ala Val Phe Pro Asp Thr Ile Thr
    210                 215                 220                 
Gly Ala Asp Ser Ser Gln Leu Leu Glu Val Ser Gly Ser Cys Val Asn
225                 230                 235                 240 
His Ser Val Thr Asp Glu Pro Pro Lys Met His Cys Ser Ala Glu Gly
                245                 250                 255     
Glu Trp Leu Val Pro Ile Gly Lys Cys Met Cys Lys Ala Gly Tyr Glu
            260                 265                 270         
Glu Lys Asn Gly Thr Cys Gln Val Cys Arg Pro Gly Phe Phe Lys Ala
        275                 280                 285             
Ser Pro His Ile Gln Ser Cys Gly Lys Cys Pro Pro His Ser Tyr Thr
    290                 295                 300                 
His Glu Glu Ala Ser Thr Ser Cys Val Cys Glu Lys Asp Tyr Phe Arg
305                 310                 315                 320 
Arg Glu Ser Asp Pro Pro Thr Met Ala Cys Thr Arg Pro Pro Ser Ala
                325                 330                 335     
Pro Arg Asn Ala Ile Ser Asn Val Asn Glu Thr Ser Val Phe Leu Glu
            340                 345                 350         
Trp Ile Pro Pro Ala Asp Thr Gly Gly Arg Lys Asp Val Ser Tyr Tyr
        355                 360                 365             
Ile Ala Cys Lys Lys Cys Asn Ser His Ala Gly Val Cys Glu Glu Cys
    370                 375                 380                 
Gly Gly His Val Arg Tyr Leu Pro Arg Gln Ser Gly Leu Lys Asn Thr
385                 390                 395                 400 
Ser Val Met Met Val Asp Leu Leu Ala His Thr Asn Tyr Thr Phe Glu
                405                 410                 415     
Ile Glu Ala Val Asn Gly Val Ser Asp Leu Ser Pro Gly Ala Arg Gln
            420                 425                 430         
Tyr Val Ser Val Asn Val Thr Thr Asn Gln Ala Ala Pro Ser Pro Val
        435                 440                 445             
Thr Asn Val Lys Lys Gly Lys Ile Ala Lys Asn Ser Ile Ser Leu Ser
    450                 455                 460                 
Trp Gln Glu Pro Asp Arg Pro Asn Gly Ile Ile Leu Glu Tyr Glu Ile
465                 470                 475                 480 
Lys His Phe Glu Lys Asp Gln Glu Thr Ser Tyr Thr Ile Ile Lys Ser
                485                 490                 495     
Lys Glu Thr Thr Ile Thr Ala Glu Gly Leu Lys Pro Ala Ser Val Tyr
            500                 505                 510         
Val Phe Gln Ile Arg Ala Arg Thr Ala Ala Gly Tyr Gly Val Phe Ser
        515                 520                 525             
Arg Arg Phe Glu Phe Glu Thr Thr Pro Val Phe Ala Ala Ser Ser Asp
    530                 535                 540                 
Gln Ser Gln Ile Pro Val Ile Ala Val Ser Val Thr Val Gly Val Ile
545                 550                 555                 560 
Leu Leu Ala Val Val Ile Gly Val Leu Leu Ser Gly Arg Arg Cys Gly
                565                 570                 575     
Tyr Ser Lys Ala Lys Gln Asp Pro Glu Glu Glu Lys Met His Phe His
            580                 585                 590         
Asn Gly His Ile Lys Leu Pro Gly Val Arg Thr Tyr Ile Asp Pro His
        595                 600                 605             
Thr Tyr Glu Asp Pro Asn Gln Ala Val His Glu Phe Ala Lys Glu Ile
    610                 615                 620                 
Glu Ala Ser Cys Ile Thr Ile Glu Arg Val Ile Gly Ala Gly Glu Phe
625                 630                 635                 640 
Gly Glu Val Cys Ser Gly Arg Leu Lys Leu Pro Gly Lys Arg Glu Leu
                645                 650                 655     
Pro Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr Glu Lys Gln Arg
            660                 665                 670         
Arg Asp Phe Leu Gly Glu Ala Ser Ile Met Gly Gln Phe Asp His Pro
        675                 680                 685             
Asn Ile Ile His Leu Glu Gly Val Val Thr Lys Ser Lys Pro Val Met
    690                 695                 700                 
Ile Val Thr Glu Tyr Met Glu Asn Gly Ser Leu Asp Thr Phe Leu Lys
705                 710                 715                 720 
Lys Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met Leu Arg
                725                 730                 735     
Gly Ile Ser Ala Gly Met Lys Tyr Leu Ser Asp Met Gly Tyr Val His
            740                 745                 750         
Arg Asp Leu Ala Ala Arg Asn Ile Leu Ile Asn Ser Asn Leu Val Cys
        755                 760                 765             
Lys Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro Glu
    770                 775                 780                 
Ala Ala Tyr Thr Thr Arg Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala
785                 790                 795                 800 
Pro Glu Ala Ile Ala Phe Arg Lys Phe Thr Ser Ala Ser Asp Val Trp
                805                 810                 815     
Ser Tyr Gly Ile Val Met Trp Glu Val Val Ser Tyr Gly Glu Arg Pro
            820                 825                 830         
Tyr Trp Glu Met Thr Asn Gln Asp Val Ile Lys Ala Val Glu Glu Gly
        835                 840                 845             
Tyr Arg Leu Pro Ser Pro Met Asp Cys Pro Ala Ala Leu Tyr Gln Leu
    850                 855                 860                 
Met Leu Asp Cys Trp Gln Lys Glu Arg Asn Ser Arg Pro Lys Phe Asp
865                 870                 875                 880 
Glu Ile Val Asn Met Leu Asp Lys Leu Ile Arg Asn Pro Ser Ser Leu
                885                 890                 895     
Lys Thr Leu Val Asn Ala Ser Cys Arg Val Ser Asn Leu Leu Ala Glu
            900                 905                 910         
His Ser Pro Leu Gly Ser Gly Ala Tyr Arg Ser Val Gly Glu Trp Leu
        915                 920                 925             
Glu Ala Ile Lys Met Gly Arg Tyr Thr Glu Ile Phe Met Glu Asn Gly
    930                 935                 940                 
Tyr Ser Ser Met Asp Ala Val Ala Gln Val Thr Leu Glu Asp Leu Arg
945                 950                 955                 960 
Arg Leu Gly Val Thr Leu Val Gly His Gln Lys Lys Ile Met Asn Ser
                965                 970                 975     
Leu Gln Glu Met Lys Val Gln Leu Val Asn Gly Met Val Pro Leu
            980                 985                 990     


<210> 399
<211> 334
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. CAB63775
<309> 2005-01-20  

<400> 399
Met Lys Asp Ser Pro Phe Gln Val Thr Lys Leu Tyr Trp Leu Asn Glu
 1               5                  10                  15      
Lys Trp Asp Phe Ile Ala Ser Ala Ser Asp Met Ala Ala Glu Gln Gly
            20                  25                  30          
Gln Ile Leu Val Ile Ala Thr Ala Ala Val Gly Gly Phe Thr Leu Leu
        35                  40                  45              
Val Ile Leu Thr Leu Phe Phe Leu Ile Thr Gly Arg Cys Gln Trp Tyr
    50                  55                  60                  
Ile Lys Ala Lys Met Lys Ser Glu Glu Lys Arg Arg Asn His Leu Gln
65                  70                  75                  80  
Asn Gly His Leu Arg Phe Pro Gly Ile Lys Thr Tyr Ile Asp Pro Asp
                85                  90                  95      
Thr Tyr Glu Asp Pro Ser Leu Ala Val His Glu Phe Ala Lys Glu Ile
            100                 105                 110         
Asp Pro Ser Arg Ile Arg Ile Glu Arg Val Ile Gly Ala Gly Glu Phe
        115                 120                 125             
Gly Glu Val Cys Ser Gly Arg Leu Lys Thr Pro Gly Lys Arg Glu Ile
    130                 135                 140                 
Pro Val Ala Ile Lys Thr Leu Lys Gly Gly His Met Asp Arg Gln Arg
145                 150                 155                 160 
Arg Asp Phe Leu Arg Glu Ala Ser Ile Met Gly Gln Phe Asp His Pro
                165                 170                 175     
Asn Ile Ile Arg Leu Glu Gly Val Val Thr Lys Arg Ser Phe Pro Ala
            180                 185                 190         
Ile Gly Val Glu Ala Phe Cys Pro Ser Phe Leu Arg Ala Gly Phe Leu
        195                 200                 205             
Asn Ser Ile Gln Ala Pro His Pro Val Pro Gly Gly Gly Ser Leu Pro
    210                 215                 220                 
Pro Arg Ile Pro Ala Gly Arg Pro Val Met Ile Val Val Glu Tyr Met
225                 230                 235                 240 
Glu Asn Gly Ser Leu Asp Ser Phe Leu Arg Lys His Asp Gly His Phe
                245                 250                 255     
Thr Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ser Gly Met
            260                 265                 270         
Lys Tyr Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg
        275                 280                 285             
Asn Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly
    290                 295                 300                 
Leu Ser Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Thr
305                 310                 315                 320 
Asp Leu Phe Gln Thr Leu Thr Leu Asn Leu Cys Tyr Ser Ala
                325                 330                 


<210> 400
<211> 998
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP004431
<309> 2005-01-26  

<400> 400
Met Val Phe Gln Thr Arg Tyr Pro Ser Trp Ile Ile Leu Cys Tyr Ile
 1               5                  10                  15      
Trp Leu Leu Arg Phe Ala His Thr Gly Glu Ala Gln Ala Ala Lys Glu
            20                  25                  30          
Val Leu Leu Leu Asp Ser Lys Ala Gln Gln Thr Glu Leu Glu Trp Ile
        35                  40                  45              
Ser Ser Pro Pro Asn Gly Trp Glu Glu Ile Ser Gly Leu Asp Glu Asn
    50                  55                  60                  
Tyr Thr Pro Ile Arg Thr Tyr Gln Val Cys Gln Val Met Glu Pro Asn
65                  70                  75                  80  
Gln Asn Asn Trp Leu Arg Thr Asn Trp Ile Ser Lys Gly Asn Ala Gln
                85                  90                  95      
Arg Ile Phe Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu
            100                 105                 110         
Pro Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr
        115                 120                 125             
Glu Thr Asp Tyr Asp Thr Gly Arg Asn Ile Arg Glu Asn Leu Tyr Val
    130                 135                 140                 
Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Gly Asp Leu
145                 150                 155                 160 
Gly Glu Arg Lys Met Lys Leu Asn Thr Glu Val Arg Glu Ile Gly Pro
                165                 170                 175     
Leu Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys
            180                 185                 190         
Ile Ala Leu Val Ser Val Lys Val Tyr Tyr Lys Lys Cys Trp Ser Ile
        195                 200                 205             
Ile Glu Asn Leu Ala Ile Phe Pro Asp Thr Val Thr Gly Ser Glu Phe
    210                 215                 220                 
Ser Ser Leu Val Glu Val Arg Gly Thr Cys Val Ser Ser Ala Glu Glu
225                 230                 235                 240 
Glu Ala Glu Asn Ala Pro Arg Met His Cys Ser Ala Glu Gly Glu Trp
                245                 250                 255     
Leu Val Pro Ile Gly Lys Cys Ile Cys Lys Ala Gly Tyr Gln Gln Lys
            260                 265                 270         
Gly Asp Thr Cys Glu Pro Cys Gly Arg Gly Phe Tyr Lys Ser Ser Ser
        275                 280                 285             
Gln Asp Leu Gln Cys Ser Arg Cys Pro Thr His Ser Phe Ser Asp Lys
    290                 295                 300                 
Glu Gly Ser Ser Arg Cys Glu Cys Glu Asp Gly Tyr Tyr Arg Ala Pro
305                 310                 315                 320 
Ser Asp Pro Pro Tyr Val Ala Cys Thr Arg Pro Pro Ser Ala Pro Gln
                325                 330                 335     
Asn Leu Ile Phe Asn Ile Asn Gln Thr Thr Val Ser Leu Glu Trp Ser
            340                 345                 350         
Pro Pro Ala Asp Asn Gly Gly Arg Asn Asp Val Thr Tyr Arg Ile Leu
        355                 360                 365             
Cys Lys Arg Cys Ser Trp Glu Gln Gly Glu Cys Val Pro Cys Gly Ser
    370                 375                 380                 
Asn Ile Gly Tyr Met Pro Gln Gln Thr Gly Leu Glu Asp Asn Tyr Val
385                 390                 395                 400 
Thr Val Met Asp Leu Leu Ala His Ala Asn Tyr Thr Phe Glu Val Glu
                405                 410                 415     
Ala Val Asn Gly Val Ser Asp Leu Ser Arg Ser Gln Arg Leu Phe Ala
            420                 425                 430         
Ala Val Ser Ile Thr Thr Gly Gln Ala Ala Pro Ser Gln Val Ser Gly
        435                 440                 445             
Val Met Lys Glu Arg Val Leu Gln Arg Ser Val Glu Leu Ser Trp Gln
    450                 455                 460                 
Glu Pro Glu His Pro Asn Gly Val Ile Thr Glu Tyr Glu Ile Lys Tyr
465                 470                 475                 480 
Tyr Glu Lys Asp Gln Arg Glu Arg Thr Tyr Ser Thr Val Lys Thr Lys
                485                 490                 495     
Ser Thr Ser Ala Ser Ile Asn Asn Leu Lys Pro Gly Thr Val Tyr Val
            500                 505                 510         
Phe Gln Ile Arg Ala Phe Thr Ala Ala Gly Tyr Gly Asn Tyr Ser Pro
        515                 520                 525             
Arg Leu Asp Val Ala Thr Leu Glu Glu Ala Thr Gly Lys Met Phe Glu
    530                 535                 540                 
Ala Thr Ala Val Ser Ser Glu Gln Asn Pro Val Ile Ile Ile Ala Val
545                 550                 555                 560 
Val Ala Val Ala Gly Thr Ile Ile Leu Val Phe Met Val Phe Gly Phe
                565                 570                 575     
Ile Ile Gly Arg Arg His Cys Gly Tyr Ser Lys Ala Asp Gln Glu Gly
            580                 585                 590         
Asp Glu Glu Leu Tyr Phe His Phe Lys Phe Pro Gly Thr Lys Thr Tyr
        595                 600                 605             
Ile Asp Pro Glu Thr Tyr Glu Asp Pro Asn Arg Ala Val His Gln Phe
    610                 615                 620                 
Ala Lys Glu Leu Asp Ala Ser Cys Ile Lys Ile Glu Arg Val Ile Gly
625                 630                 635                 640 
Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu Lys Leu Pro Gly
                645                 650                 655     
Lys Arg Asp Val Ala Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr
            660                 665                 670         
Glu Lys Gln Arg Arg Asp Phe Leu Cys Glu Ala Ser Ile Met Gly Gln
        675                 680                 685             
Phe Asp His Pro Asn Val Val His Leu Glu Gly Val Val Thr Arg Gly
    690                 695                 700                 
Lys Pro Val Met Ile Val Ile Glu Phe Met Glu Asn Gly Ala Leu Asp
705                 710                 715                 720 
Ala Phe Leu Arg Lys His Asp Gly Gln Phe Thr Val Ile Gln Leu Val
                725                 730                 735     
Gly Met Leu Arg Gly Ile Ala Ala Gly Met Arg Tyr Leu Ala Asp Met
            740                 745                 750         
Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser
        755                 760                 765             
Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Ile Glu
    770                 775                 780                 
Asp Asp Pro Glu Ala Val Tyr Thr Thr Thr Gly Gly Lys Ile Pro Val
785                 790                 795                 800 
Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr Arg Lys Phe Thr Ser Ala
                805                 810                 815     
Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Tyr
            820                 825                 830         
Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Lys Ala
        835                 840                 845             
Ile Glu Glu Gly Tyr Arg Leu Pro Ala Pro Met Asp Cys Pro Ala Gly
    850                 855                 860                 
Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu Arg Ala Glu Arg
865                 870                 875                 880 
Pro Lys Phe Glu Gln Ile Val Gly Ile Leu Asp Lys Met Ile Arg Asn
                885                 890                 895     
Pro Asn Ser Leu Lys Thr Pro Leu Gly Thr Cys Ser Arg Pro Ile Ser
            900                 905                 910         
Pro Leu Leu Asp Gln Asn Thr Pro Asp Phe Thr Thr Phe Cys Ser Val
        915                 920                 925             
Gly Glu Trp Leu Gln Ala Ile Lys Met Glu Arg Tyr Lys Asp Asn Phe
    930                 935                 940                 
Thr Ala Ala Gly Tyr Asn Ser Leu Glu Ser Val Ala Arg Met Thr Ile
945                 950                 955                 960 
Glu Asp Val Met Ser Leu Gly Ile Thr Leu Val Gly His Gln Lys Lys
                965                 970                 975     
Ile Met Ser Ser Ile Gln Thr Met Arg Ala Gln Met Leu His Leu His
            980                 985                 990         
Gly Thr Gly Ile Gln Val
        995             


<210> 401
<211> 1005
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP065387
<309> 2004-11-16  

<400> 401
Met Ala Pro Ala Arg Gly Arg Leu Pro Pro Ala Leu Trp Val Val Thr
 1               5                  10                  15      
Ala Ala Ala Ala Ala Ala Thr Cys Val Ser Ala Ala Arg Gly Glu Val
            20                  25                  30          
Asn Leu Leu Asp Thr Ser Thr Ile His Gly Asp Trp Gly Trp Leu Thr
        35                  40                  45              
Tyr Pro Ala His Gly Trp Asp Ser Ile Asn Glu Val Asp Glu Ser Phe
    50                  55                  60                  
Gln Pro Ile His Thr Tyr Gln Val Cys Asn Val Met Ser Pro Asn Gln
65                  70                  75                  80  
Asn Asn Trp Leu Arg Thr Ser Trp Val Pro Arg Asp Gly Ala Arg Arg
                85                  90                  95      
Val Tyr Ala Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Met Pro
            100                 105                 110         
Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Leu Glu
        115                 120                 125             
Ser Asp Arg Asp Leu Gly Ala Ser Thr Gln Glu Ser Gln Phe Leu Lys
    130                 135                 140                 
Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gly Ala Asp Leu Gly
145                 150                 155                 160 
Val Arg Arg Leu Lys Leu Asn Thr Glu Val Arg Ser Val Gly Pro Leu
                165                 170                 175     
Ser Lys Arg Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Leu
            180                 185                 190         
Ala Ile Leu Ser Leu Arg Ile Tyr Tyr Lys Lys Cys Pro Ala Met Val
        195                 200                 205             
Arg Asn Leu Ala Ala Phe Ser Glu Ala Val Thr Gly Ala Asp Ser Ser
    210                 215                 220                 
Ser Leu Val Glu Val Arg Gly Gln Cys Val Arg His Ser Glu Glu Arg
225                 230                 235                 240 
Asp Thr Pro Lys Met Tyr Cys Ser Ala Glu Gly Glu Trp Leu Val Pro
                245                 250                 255     
Ile Gly Lys Cys Val Cys Ser Ala Gly Tyr Glu Glu Arg Arg Asp Ala
            260                 265                 270         
Cys Val Ala Cys Glu Leu Gly Phe Tyr Lys Ser Ala Pro Gly Asp Gln
        275                 280                 285             
Leu Cys Ala Arg Cys Pro Pro His Ser His Ser Ala Ala Pro Ala Ala
    290                 295                 300                 
Gln Ala Cys His Cys Asp Leu Ser Tyr Tyr Arg Ala Ala Leu Asp Pro
305                 310                 315                 320 
Pro Ser Ser Ala Cys Thr Arg Pro Pro Ser Ala Pro Val Asn Leu Ile
                325                 330                 335     
Ser Ser Val Asn Gly Thr Ser Val Thr Leu Glu Trp Ala Pro Pro Leu
            340                 345                 350         
Asp Pro Gly Gly Arg Ser Asp Ile Thr Tyr Asn Ala Val Cys Arg Arg
        355                 360                 365             
Cys Pro Trp Ala Leu Ser Arg Cys Glu Ala Cys Gly Ser Gly Thr Arg
    370                 375                 380                 
Phe Val Pro Gln Gln Thr Ser Leu Val Gln Ala Ser Leu Leu Val Ala
385                 390                 395                 400 
Asn Leu Leu Ala His Met Asn Tyr Ser Phe Trp Ile Glu Ala Val Asn
                405                 410                 415     
Gly Val Ser Asp Leu Ser Pro Glu Pro Arg Arg Ala Ala Val Val Asn
            420                 425                 430         
Ile Thr Thr Asn Gln Ala Ala Pro Ser Gln Val Val Val Ile Arg Gln
        435                 440                 445             
Glu Arg Ala Gly Gln Thr Ser Val Ser Leu Leu Trp Gln Glu Pro Glu
    450                 455                 460                 
Gln Pro Asn Gly Ile Ile Leu Glu Tyr Glu Ile Lys Tyr Tyr Glu Lys
465                 470                 475                 480 
Asp Lys Glu Met Gln Ser Tyr Ser Thr Leu Lys Ala Val Thr Thr Arg
                485                 490                 495     
Ala Thr Val Ser Gly Leu Lys Pro Gly Thr Arg Tyr Val Phe Gln Val
            500                 505                 510         
Arg Ala Arg Thr Ser Ala Gly Cys Gly Arg Phe Ser Gln Ala Met Glu
        515                 520                 525             
Val Glu Thr Gly Lys Pro Arg Pro Arg Tyr Asp Thr Arg Thr Ile Val
    530                 535                 540                 
Trp Ile Cys Leu Thr Leu Ile Thr Gly Leu Val Val Leu Leu Leu Leu
545                 550                 555                 560 
Leu Ile Cys Lys Lys Arg His Cys Gly Tyr Ser Lys Ala Phe Gln Asp
                565                 570                 575     
Ser Asp Glu Glu Lys Met His Tyr Gln Asn Gly Gln Ala Pro Pro Pro
            580                 585                 590         
Val Phe Leu Pro Leu His His Pro Pro Gly Lys Leu Pro Glu Pro Gln
        595                 600                 605             
Phe Tyr Ala Glu Pro His Thr Tyr Glu Glu Pro Gly Arg Ala Gly Arg
    610                 615                 620                 
Ser Phe Thr Arg Glu Ile Glu Ala Ser Arg Ile His Ile Glu Lys Ile
625                 630                 635                 640 
Ile Gly Ser Gly Asp Ser Gly Glu Val Cys Tyr Gly Arg Leu Arg Val
                645                 650                 655     
Pro Gly Gln Arg Asp Val Pro Val Ala Ile Lys Ala Leu Lys Ala Gly
            660                 665                 670         
Tyr Thr Glu Arg Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met
        675                 680                 685             
Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr
    690                 695                 700                 
Arg Gly Arg Leu Ala Met Ile Val Thr Glu Tyr Met Glu Asn Gly Ser
705                 710                 715                 720 
Leu Asp Thr Phe Leu Arg Thr His Asp Gly Gln Phe Thr Ile Met Gln
                725                 730                 735     
Leu Val Gly Met Leu Arg Gly Val Gly Ala Gly Met Arg Tyr Leu Ser
            740                 745                 750         
Asp Leu Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val
        755                 760                 765             
Asp Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val
    770                 775                 780                 
Leu Glu Asp Asp Pro Asp Ala Ala Tyr Thr Thr Thr Gly Gly Lys Ile
785                 790                 795                 800 
Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Thr Phe Ser
                805                 810                 815     
Ser Ala Ser Asp Val Trp Ser Phe Gly Val Val Met Trp Glu Val Leu
            820                 825                 830         
Ala Tyr Gly Glu Arg Pro Tyr Trp Asn Met Thr Asn Arg Asp Val Ile
        835                 840                 845             
Ser Ser Val Glu Glu Gly Tyr Arg Leu Pro Ala Pro Met Gly Cys Pro
    850                 855                 860                 
His Ala Leu His Gln Leu Met Leu Asp Cys Trp His Lys Asp Arg Ala
865                 870                 875                 880 
Gln Arg Pro Arg Phe Ser Gln Ile Val Ser Val Leu Asp Ala Leu Ile
                885                 890                 895     
Arg Ser Pro Glu Ser Leu Arg Ala Thr Ala Thr Val Ser Arg Cys Pro
            900                 905                 910         
Pro Pro Ala Phe Val Arg Ser Cys Phe Asp Leu Arg Gly Gly Ser Gly
        915                 920                 925             
Gly Gly Gly Gly Leu Thr Val Gly Asp Trp Leu Asp Ser Ile Arg Met
    930                 935                 940                 
Gly Arg Tyr Arg Asp His Phe Ala Ala Gly Gly Tyr Ser Ser Leu Gly
945                 950                 955                 960 
Met Val Leu Arg Met Asn Ala Gln Asp Val Arg Ala Leu Gly Ile Thr
                965                 970                 975     
Leu Met Gly His Gln Lys Lys Ile Leu Gly Ser Ile Gln Thr Met Arg
            980                 985                 990         
Ala Gln Leu Thr Ser Thr Gln Gly Pro Arg Arg His Leu
        995                 1000                1005


<210> 402
<211> 984
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP004432
<309> 2004-11-15  

<400> 402
Met Ala Leu Asp Tyr Leu Leu Leu Leu Leu Leu Ala Ser Ala Val Ala
 1               5                  10                  15      
Ala Met Glu Glu Thr Leu Met Asp Thr Arg Thr Ala Thr Ala Glu Leu
            20                  25                  30          
Gly Trp Thr Ala Asn Pro Ala Ser Gly Trp Glu Glu Val Ser Gly Tyr
        35                  40                  45              
Asp Glu Asn Leu Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val Phe
    50                  55                  60                  
Glu Pro Asn Gln Asn Asn Trp Leu Leu Thr Thr Phe Ile Asn Arg Arg
65                  70                  75                  80  
Gly Ala His Arg Ile Tyr Thr Glu Met Arg Phe Thr Val Arg Asp Cys
                85                  90                  95      
Ser Ser Leu Pro Asn Val Pro Gly Ser Cys Lys Glu Thr Phe Asn Leu
            100                 105                 110         
Tyr Tyr Tyr Glu Thr Asp Ser Val Ile Ala Thr Lys Lys Ser Ala Phe
        115                 120                 125             
Trp Ser Glu Ala Pro Tyr Leu Lys Val Asp Thr Ile Ala Ala Asp Glu
    130                 135                 140                 
Ser Phe Ser Gln Val Asp Phe Gly Gly Arg Leu Met Lys Val Asn Thr
145                 150                 155                 160 
Glu Val Arg Ser Phe Gly Pro Leu Thr Arg Asn Gly Phe Tyr Leu Ala
                165                 170                 175     
Phe Gln Asp Tyr Gly Ala Cys Met Ser Leu Leu Ser Val Arg Val Phe
            180                 185                 190         
Phe Lys Lys Cys Pro Ser Ile Val Gln Asn Phe Ala Val Phe Pro Glu
        195                 200                 205             
Thr Met Thr Gly Ala Glu Ser Thr Ser Leu Val Ile Ala Arg Gly Thr
    210                 215                 220                 
Cys Ile Pro Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr Cys
225                 230                 235                 240 
Asn Gly Asp Gly Glu Trp Met Val Pro Ile Gly Arg Cys Thr Cys Lys
                245                 250                 255     
Pro Gly Tyr Glu Pro Glu Asn Ser Val Ala Cys Lys Ala Cys Pro Ala
            260                 265                 270         
Gly Thr Phe Lys Ala Ser Gln Glu Ala Glu Gly Cys Ser His Cys Pro
        275                 280                 285             
Ser Asn Ser Arg Ser Pro Ala Glu Ala Ser Pro Ile Cys Thr Cys Arg
    290                 295                 300                 
Thr Gly Tyr Tyr Arg Ala Asp Phe Asp Pro Pro Glu Val Ala Cys Thr
305                 310                 315                 320 
Ser Val Pro Ser Gly Pro Arg Asn Val Ile Ser Ile Val Asn Glu Thr
                325                 330                 335     
Ser Ile Ile Leu Glu Trp His Pro Pro Arg Glu Thr Gly Gly Arg Asp
            340                 345                 350         
Asp Val Thr Tyr Asn Ile Ile Cys Lys Lys Cys Arg Ala Asp Arg Arg
        355                 360                 365             
Ser Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro Arg Gln Leu
    370                 375                 380                 
Gly Leu Thr Glu Cys Arg Val Ser Ile Ser Ser Leu Trp Ala His Thr
385                 390                 395                 400 
Pro Tyr Thr Phe Asp Ile Gln Ala Ile Asn Gly Val Ser Ser Lys Ser
                405                 410                 415     
Pro Phe Pro Pro Gln His Val Ser Val Asn Ile Thr Thr Asn Gln Ala
            420                 425                 430         
Ala Pro Ser Thr Val Pro Ile Met His Gln Val Ser Ala Thr Met Arg
        435                 440                 445             
Ser Ile Thr Leu Ser Trp Pro Gln Pro Glu Gln Pro Asn Gly Ile Ile
    450                 455                 460                 
Leu Asp Tyr Glu Ile Arg Tyr Tyr Glu Lys Glu His Asn Glu Phe Asn
465                 470                 475                 480 
Ser Ser Met Ala Arg Ser Gln Thr Asn Thr Ala Arg Ile Asp Gly Leu
                485                 490                 495     
Arg Pro Gly Met Val Tyr Val Val Gln Val Arg Ala Arg Thr Val Ala
            500                 505                 510         
Gly Tyr Gly Lys Phe Ser Gly Lys Met Cys Phe Gln Thr Leu Thr Asp
        515                 520                 525             
Asp Asp Tyr Lys Ser Glu Leu Arg Glu Gln Leu Pro Leu Ile Ala Gly
    530                 535                 540                 
Ser Ala Ala Ala Gly Val Val Phe Val Val Ser Leu Val Ala Ile Ser
545                 550                 555                 560 
Ile Val Cys Ser Arg Lys Arg Ala Tyr Ser Lys Glu Ala Val Tyr Ser
                565                 570                 575     
Asp Lys Leu Gln His Tyr Ser Thr Gly Arg Gly Ser Pro Gly Met Lys
            580                 585                 590         
Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg
        595                 600                 605             
Glu Phe Ala Lys Glu Ile Asp Val Ser Phe Val Lys Ile Glu Glu Val
    610                 615                 620                 
Ile Gly Ala Gly Glu Phe Gly Glu Val Tyr Lys Gly Arg Leu Lys Leu
625                 630                 635                 640 
Pro Gly Lys Arg Glu Ile Tyr Val Ala Ile Lys Thr Leu Lys Ala Gly
                645                 650                 655     
Tyr Ser Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met
            660                 665                 670         
Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr
        675                 680                 685             
Lys Ser Arg Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn Gly Ala
    690                 695                 700                 
Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val Ile Gln
705                 710                 715                 720 
Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala
                725                 730                 735     
Glu Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val
            740                 745                 750         
Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Tyr
        755                 760                 765             
Leu Gln Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly
    770                 775                 780                 
Lys Ile Pro Val Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys
785                 790                 795                 800 
Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu
                805                 810                 815     
Val Met Ser Phe Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp
            820                 825                 830         
Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp
        835                 840                 845             
Cys Pro Ala Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp
    850                 855                 860                 
Arg Asn Ser Arg Pro Arg Phe Ala Glu Ile Val Asn Thr Leu Asp Lys
865                 870                 875                 880 
Met Ile Arg Asn Pro Ala Ser Leu Lys Thr Val Ala Thr Ile Thr Ala
                885                 890                 895     
Val Pro Ser Gln Pro Leu Leu Asp Arg Ser Ile Pro Asp Phe Thr Ala
            900                 905                 910         
Phe Thr Thr Val Asp Asp Trp Leu Ser Ala Ile Lys Met Val Gln Tyr
        915                 920                 925             
Arg Asp Ser Phe Leu Thr Ala Gly Phe Thr Ser Leu Gln Leu Val Thr
    930                 935                 940                 
Gln Met Thr Ser Glu Asp Leu Leu Arg Ile Gly Ile Thr Leu Ala Gly
945                 950                 955                 960 
His Gln Lys Lys Ile Leu Asn Ser Ile His Ser Met Arg Val Gln Ile
                965                 970                 975     
Ser Gln Ser Pro Thr Ala Met Ala
            980                 


<210> 403
<211> 1055
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. AAB94602
<309> 2000-11-29  

<400> 403
Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu
 1               5                  10                  15      
Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu
            20                  25                  30          
Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly
        35                  40                  45              
Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val
    50                  55                  60                  
Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg
65                  70                  75                  80  
Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp
                85                  90                  95      
Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn
            100                 105                 110         
Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro
        115                 120                 125             
Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp
    130                 135                 140                 
Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn
145                 150                 155                 160 
Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu
                165                 170                 175     
Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val
            180                 185                 190         
Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln
        195                 200                 205             
Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly
    210                 215                 220                 
Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr
225                 230                 235                 240 
Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys
                245                 250                 255     
Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys
            260                 265                 270         
Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His
        275                 280                 285             
Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val
    290                 295                 300                 
Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro
305                 310                 315                 320 
Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn
                325                 330                 335     
Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly
            340                 345                 350         
Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly
        355                 360                 365             
Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg
    370                 375                 380                 
Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala
385                 390                 395                 400 
His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp
                405                 410                 415     
Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn
            420                 425                 430         
Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr
        435                 440                 445             
Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly
    450                 455                 460                 
Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu
465                 470                 475                 480 
Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln
                485                 490                 495     
Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr
            500                 505                 510         
Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met
        515                 520                 525             
Thr Glu Ala Glu Tyr Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile
    530                 535                 540                 
Ile Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val Val
545                 550                 555                 560 
Ile Ala Ile Val Cys Asn Arg Arg Gly Phe Glu Arg Ala Asp Ser Glu
                565                 570                 575     
Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro Gly
            580                 585                 590         
Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala
        595                 600                 605             
Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile Glu
    610                 615                 620                 
Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His Leu
625                 630                 635                 640 
Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu Lys
                645                 650                 655     
Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser
            660                 665                 670         
Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly Val
        675                 680                 685             
Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn
    690                 695                 700                 
Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val
705                 710                 715                 720 
Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr
                725                 730                 735     
Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile
            740                 745                 750         
Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser
        755                 760                 765             
Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala Leu
    770                 775                 780                 
Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr
785                 790                 795                 800 
Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met
                805                 810                 815     
Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr Asn
            820                 825                 830         
Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro
        835                 840                 845             
Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln
    850                 855                 860                 
Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr Leu
865                 870                 875                 880 
Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro Leu
                885                 890                 895     
Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp Tyr
            900                 905                 910         
Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met Gly
        915                 920                 925             
Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp Val
    930                 935                 940                 
Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr Leu
945                 950                 955                 960 
Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg Ala
                965                 970                 975     
Gln Met Asn Gln Ile Gln Ser Val Glu Gly Gln Pro Leu Ala Arg Arg
            980                 985                 990         
Pro Arg Ala Thr Gly Arg Thr Lys Arg Cys Gln Pro Arg Asp Val Thr
        995                 1000                1005            
Lys Lys Thr Cys Asn Ser Asn Asp Gly Lys Lys Lys Gly Met Gly Lys
    1010                1015                1020                
Lys Lys Thr Asp Pro Gly Arg Gly Arg Glu Ile Gln Gly Ile Phe Phe
1025                1030                1035                1040
Lys Glu Asp Ser His Lys Glu Ser Asn Asp Cys Ser Cys Gly Gly
                1045                1050                1055


<210> 404
<211> 998
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP004434
<309> 2004-11-16  

<400> 404
Met Ala Arg Ala Arg Pro Pro Pro Pro Pro Ser Pro Pro Pro Gly Leu
 1               5                  10                  15      
Leu Pro Leu Leu Pro Pro Leu Leu Leu Leu Pro Leu Leu Leu Leu Pro
            20                  25                  30          
Ala Gly Cys Arg Ala Leu Glu Glu Thr Leu Met Asp Thr Lys Trp Val
        35                  40                  45              
Thr Ser Glu Leu Ala Trp Thr Ser His Pro Glu Ser Gly Trp Glu Glu
    50                  55                  60                  
Val Ser Gly Tyr Asp Glu Ala Met Asn Pro Ile Arg Thr Tyr Gln Val
65                  70                  75                  80  
Cys Asn Val Arg Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Gly Phe
                85                  90                  95      
Ile Trp Arg Arg Asp Val Gln Arg Val Tyr Val Glu Leu Lys Phe Thr
            100                 105                 110         
Val Arg Asp Cys Asn Ser Ile Pro Asn Ile Pro Gly Ser Cys Lys Glu
        115                 120                 125             
Thr Phe Asn Leu Phe Tyr Tyr Glu Ala Asp Ser Asp Val Ala Ser Ala
    130                 135                 140                 
Ser Ser Pro Phe Trp Met Glu Asn Pro Tyr Val Lys Val Asp Thr Ile
145                 150                 155                 160 
Ala Pro Asp Glu Ser Phe Ser Arg Leu Asp Ala Gly Arg Val Asn Thr
                165                 170                 175     
Lys Val Arg Ser Phe Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu Ala
            180                 185                 190         
Phe Gln Asp Gln Gly Ala Cys Met Ser Leu Ile Ser Val Arg Ala Phe
        195                 200                 205             
Tyr Lys Lys Cys Ala Ser Thr Thr Ala Gly Phe Ala Leu Phe Pro Glu
    210                 215                 220                 
Thr Leu Thr Gly Ala Glu Pro Thr Ser Leu Val Ile Ala Pro Gly Thr
225                 230                 235                 240 
Cys Ile Pro Asn Ala Val Glu Val Ser Val Pro Leu Lys Leu Tyr Cys
                245                 250                 255     
Asn Gly Asp Gly Glu Trp Met Val Pro Val Gly Ala Cys Thr Cys Ala
            260                 265                 270         
Thr Gly His Glu Pro Ala Ala Lys Glu Ser Gln Cys Arg Pro Cys Pro
        275                 280                 285             
Pro Gly Ser Tyr Lys Ala Lys Gln Gly Glu Gly Pro Cys Leu Pro Cys
    290                 295                 300                 
Pro Pro Asn Ser Arg Thr Thr Ser Pro Ala Ala Ser Ile Cys Thr Cys
305                 310                 315                 320 
His Asn Asn Phe Tyr Arg Ala Asp Ser Asp Ser Ala Asp Ser Ala Cys
                325                 330                 335     
Thr Thr Val Pro Ser Pro Pro Arg Gly Val Ile Ser Asn Val Asn Glu
            340                 345                 350         
Thr Ser Leu Ile Leu Glu Trp Ser Glu Pro Arg Asp Leu Gly Gly Arg
        355                 360                 365             
Asp Asp Leu Leu Tyr Asn Val Ile Cys Lys Lys Cys His Gly Ala Gly
    370                 375                 380                 
Gly Ala Ser Ala Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro
385                 390                 395                 400 
Arg Gln Leu Gly Leu Thr Glu Arg Arg Val His Ile Ser His Leu Leu
                405                 410                 415     
Ala His Thr Arg Tyr Thr Phe Glu Val Gln Ala Val Asn Gly Val Ser
            420                 425                 430         
Gly Lys Ser Pro Leu Pro Pro Arg Tyr Ala Ala Val Asn Ile Thr Thr
        435                 440                 445             
Asn Gln Ala Ala Pro Ser Glu Val Pro Thr Leu Arg Leu His Ser Ser
    450                 455                 460                 
Ser Gly Ser Ser Leu Thr Leu Ser Trp Ala Pro Pro Glu Arg Pro Asn
465                 470                 475                 480 
Gly Val Ile Leu Asp Tyr Glu Met Lys Tyr Phe Glu Lys Ser Glu Gly
                485                 490                 495     
Ile Ala Ser Thr Val Thr Ser Gln Met Asn Ser Val Gln Leu Asp Gly
            500                 505                 510         
Leu Arg Pro Asp Ala Arg Tyr Val Val Gln Val Arg Ala Arg Thr Val
        515                 520                 525             
Ala Gly Tyr Gly Gln Tyr Ser Arg Pro Ala Glu Phe Glu Thr Thr Ser
    530                 535                 540                 
Glu Arg Gly Ser Gly Ala Gln Gln Leu Gln Glu Gln Leu Pro Leu Ile
545                 550                 555                 560 
Val Gly Ser Ala Thr Ala Gly Leu Val Phe Val Val Ala Val Val Val
                565                 570                 575     
Ile Ala Ile Val Cys Leu Arg Lys Gln Arg His Gly Ser Asp Ser Glu
            580                 585                 590         
Tyr Thr Glu Lys Leu Gln Gln Tyr Ile Ala Pro Gly Met Lys Val Tyr
        595                 600                 605             
Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe
    610                 615                 620                 
Ala Lys Glu Ile Asp Val Ser Cys Val Lys Ile Glu Glu Val Ile Gly
625                 630                 635                 640 
Ala Gly Glu Phe Gly Glu Val Cys Arg Gly Arg Leu Lys Gln Pro Gly
                645                 650                 655     
Arg Arg Glu Val Phe Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr
            660                 665                 670         
Glu Arg Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met Gly Gln
        675                 680                 685             
Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Lys Ser
    690                 695                 700                 
Arg Pro Val Met Ile Leu Thr Glu Phe Met Glu Asn Cys Ala Leu Asp
705                 710                 715                 720 
Ser Phe Leu Arg Leu Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val
                725                 730                 735     
Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ser Glu Met
            740                 745                 750         
Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser
        755                 760                 765             
Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu
    770                 775                 780                 
Asp Asp Pro Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile
785                 790                 795                 800 
Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys Phe Thr
                805                 810                 815     
Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met
            820                 825                 830         
Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile
        835                 840                 845             
Asn Ala Val Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp Cys Pro
    850                 855                 860                 
Thr Ala Leu His Gln Leu Met Leu Asp Cys Trp Val Arg Asp Arg Asn
865                 870                 875                 880 
Leu Arg Pro Lys Phe Ser Gln Ile Val Asn Thr Leu Asp Lys Leu Ile
                885                 890                 895     
Arg Asn Ala Ala Ser Leu Lys Val Ile Ala Ser Ala Gln Ser Gly Met
            900                 905                 910         
Ser Gln Pro Leu Leu Asp Arg Thr Val Pro Asp Tyr Thr Thr Phe Thr
        915                 920                 925             
Thr Val Gly Asp Trp Leu Asp Ala Ile Lys Met Gly Arg Tyr Lys Glu
    930                 935                 940                 
Ser Phe Val Ser Ala Gly Phe Ala Ser Phe Asp Leu Val Ala Gln Met
945                 950                 955                 960 
Thr Ala Glu Asp Leu Leu Arg Ile Gly Val Thr Leu Ala Gly His Gln
                965                 970                 975     
Lys Lys Ile Leu Ser Ser Ile Gln Asp Met Arg Leu Gln Met Asn Gln
            980                 985                 990         
Thr Leu Pro Val Gln Val
        995             


<210> 405
<211> 987
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No.NP004435
<309> 2004-11-16  

<400> 405
Met Glu Leu Arg Val Leu Leu Cys Trp Ala Ser Leu Ala Ala Ala Leu
 1               5                  10                  15      
Glu Glu Thr Leu Leu Asn Thr Lys Leu Glu Thr Ala Asp Leu Lys Trp
            20                  25                  30          
Val Thr Phe Pro Gln Val Asp Gly Gln Trp Glu Glu Leu Ser Gly Leu
        35                  40                  45              
Asp Glu Glu Gln His Ser Val Arg Thr Tyr Glu Val Cys Asp Val Gln
    50                  55                  60                  
Arg Ala Pro Gly Gln Ala His Trp Leu Arg Thr Gly Trp Val Pro Arg
65                  70                  75                  80  
Arg Gly Ala Val His Val Tyr Ala Thr Leu Arg Phe Thr Met Leu Glu
                85                  90                  95      
Cys Leu Ser Leu Pro Arg Ala Gly Arg Ser Cys Lys Glu Thr Phe Thr
            100                 105                 110         
Val Phe Tyr Tyr Glu Ser Asp Ala Asp Thr Ala Thr Ala Leu Thr Pro
        115                 120                 125             
Ala Trp Met Glu Asn Pro Tyr Ile Lys Val Asp Thr Val Ala Ala Glu
    130                 135                 140                 
His Leu Thr Arg Lys Arg Pro Gly Ala Glu Ala Thr Gly Lys Val Asn
145                 150                 155                 160 
Val Lys Thr Leu Arg Leu Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu
                165                 170                 175     
Ala Phe Gln Asp Gln Gly Ala Cys Met Ala Leu Leu Ser Leu His Leu
            180                 185                 190         
Phe Tyr Lys Lys Cys Ala Gln Leu Thr Val Asn Leu Thr Arg Phe Pro
        195                 200                 205             
Glu Thr Val Pro Arg Glu Leu Val Val Pro Val Ala Gly Ser Cys Val
    210                 215                 220                 
Val Asp Ala Val Pro Ala Pro Gly Pro Ser Pro Ser Leu Tyr Cys Arg
225                 230                 235                 240 
Glu Asp Gly Gln Trp Ala Glu Gln Pro Val Thr Gly Cys Ser Cys Ala
                245                 250                 255     
Pro Gly Phe Glu Ala Ala Glu Gly Asn Thr Lys Cys Arg Ala Cys Ala
            260                 265                 270         
Gln Gly Thr Phe Lys Pro Leu Ser Gly Glu Gly Ser Cys Gln Pro Cys
        275                 280                 285             
Pro Ala Asn Ser His Ser Asn Thr Ile Gly Ser Ala Val Cys Gln Cys
    290                 295                 300                 
Arg Val Gly Tyr Phe Arg Ala Arg Thr Asp Pro Arg Gly Ala Pro Cys
305                 310                 315                 320 
Thr Thr Pro Pro Ser Ala Pro Arg Ser Val Val Ser Arg Leu Asn Gly
                325                 330                 335     
Ser Ser Leu His Leu Glu Trp Ser Ala Pro Leu Glu Ser Gly Gly Arg
            340                 345                 350         
Glu Asp Leu Thr Tyr Ala Leu Arg Cys Arg Glu Cys Arg Pro Gly Gly
        355                 360                 365             
Ser Cys Ala Pro Cys Gly Gly Asp Leu Thr Phe Asp Pro Gly Pro Arg
    370                 375                 380                 
Asp Leu Val Glu Pro Trp Val Val Val Arg Gly Leu Arg Pro Asp Phe
385                 390                 395                 400 
Thr Tyr Thr Phe Glu Val Thr Ala Leu Asn Gly Val Ser Ser Leu Ala
                405                 410                 415     
Thr Gly Pro Val Pro Phe Glu Pro Val Asn Val Thr Thr Asp Arg Glu
            420                 425                 430         
Val Pro Pro Ala Val Ser Asp Ile Arg Val Thr Arg Ser Ser Pro Ser
        435                 440                 445             
Ser Leu Ser Leu Ala Trp Ala Val Pro Arg Ala Pro Ser Gly Ala Val
    450                 455                 460                 
Leu Asp Tyr Glu Val Lys Tyr His Glu Lys Gly Ala Glu Gly Pro Ser
465                 470                 475                 480 
Ser Val Arg Phe Leu Lys Thr Ser Glu Asn Arg Ala Glu Leu Arg Gly
                485                 490                 495     
Leu Lys Arg Gly Ala Ser Tyr Leu Val Gln Val Arg Ala Arg Ser Glu
            500                 505                 510         
Ala Gly Tyr Gly Pro Phe Gly Gln Glu His His Ser Gln Thr Gln Leu
        515                 520                 525             
Asp Glu Ser Glu Gly Trp Arg Glu Gln Leu Ala Leu Ile Ala Gly Thr
    530                 535                 540                 
Ala Val Val Gly Val Val Leu Val Leu Val Val Ile Val Val Ala Val
545                 550                 555                 560 
Leu Cys Leu Arg Lys Gln Ser Asn Gly Arg Glu Ala Glu Tyr Ser Asp
                565                 570                 575     
Lys His Gly Gln Tyr Leu Ile Gly His Gly Thr Lys Val Tyr Ile Asp
            580                 585                 590         
Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe Ala Lys
        595                 600                 605             
Glu Ile Asp Val Ser Tyr Val Lys Ile Glu Glu Val Ile Gly Ala Gly
    610                 615                 620                 
Glu Phe Gly Glu Val Cys Arg Gly Arg Leu Lys Ala Pro Gly Lys Lys
625                 630                 635                 640 
Glu Ser Cys Val Ala Ile Lys Thr Leu Lys Gly Gly Tyr Thr Glu Arg
                645                 650                 655     
Gln Arg Arg Glu Phe Leu Ser Glu Ala Ser Ile Met Gly Gln Phe Glu
            660                 665                 670         
His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Asn Ser Met Pro
        675                 680                 685             
Val Met Ile Leu Thr Glu Phe Met Glu Asn Gly Ala Leu Asp Ser Phe
    690                 695                 700                 
Leu Arg Leu Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met
705                 710                 715                 720 
Leu Arg Gly Ile Ala Ser Gly Met Arg Tyr Leu Ala Glu Met Ser Tyr
                725                 730                 735     
Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu
            740                 745                 750         
Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu Glu Asn
        755                 760                 765             
Ser Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile Pro Ile
    770                 775                 780                 
Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Lys Phe Thr Ser Ala
785                 790                 795                 800 
Ser Asp Ala Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Phe
                805                 810                 815     
Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Asn Ala
            820                 825                 830         
Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Pro Asp Cys Pro Thr Ser
        835                 840                 845             
Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp Arg Asn Ala Arg
    850                 855                 860                 
Pro Arg Phe Pro Gln Val Val Ser Ala Leu Asp Lys Met Ile Arg Asn
865                 870                 875                 880 
Pro Ala Ser Leu Lys Ile Val Ala Arg Glu Asn Gly Gly Ala Ser His
                885                 890                 895     
Pro Leu Leu Asp Gln Arg Gln Pro His Tyr Ser Ala Phe Gly Ser Val
            900                 905                 910         
Gly Glu Trp Leu Arg Ala Ile Lys Met Gly Arg Tyr Glu Glu Ser Phe
        915                 920                 925             
Ala Ala Ala Gly Phe Gly Ser Phe Glu Leu Val Ser Gln Ile Ser Ala
    930                 935                 940                 
Glu Asp Leu Leu Arg Ile Gly Val Thr Leu Ala Gly His Gln Lys Lys
945                 950                 955                 960 
Ile Leu Ala Ser Val Gln His Met Lys Ser Gln Ala Lys Pro Gly Thr
                965                 970                 975     
Pro Gly Gly Thr Gly Gly Pro Ala Pro Gln Tyr
            980                 985         


<210> 406
<211> 1006
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No.NP004436
<309> 2004-11-29  

<400> 406
Met Val Cys Ser Leu Trp Val Leu Leu Leu Val Ser Ser Val Leu Ala
 1               5                  10                  15      
Leu Glu Glu Val Leu Leu Asp Thr Thr Gly Glu Thr Ser Glu Ile Gly
            20                  25                  30          
Trp Leu Thr Tyr Pro Pro Gly Gly Trp Asp Glu Val Ser Val Leu Asp
        35                  40                  45              
Asp Gln Arg Arg Leu Thr Arg Thr Phe Glu Ala Cys His Val Ala Gly
    50                  55                  60                  
Ala Pro Pro Gly Thr Gly Gln Asp Asn Trp Leu Gln Thr His Phe Val
65                  70                  75                  80  
Glu Arg Arg Gly Ala Gln Arg Ala His Ile Arg Leu His Phe Ser Val
                85                  90                  95      
Arg Ala Cys Ser Ser Leu Gly Val Ser Gly Gly Thr Cys Arg Glu Thr
            100                 105                 110         
Phe Thr Leu Tyr Tyr Arg Gln Ala Glu Glu Pro Asp Ser Pro Asp Ser
        115                 120                 125             
Val Ser Ser Trp His Leu Lys Arg Trp Thr Lys Val Asp Thr Ile Ala
    130                 135                 140                 
Ala Asp Glu Ser Phe Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser
145                 150                 155                 160 
Ser Ala Ala Trp Ala Val Gly Pro His Gly Ala Gly Gln Arg Ala Gly
                165                 170                 175     
Leu Gln Leu Asn Val Lys Glu Arg Ser Phe Gly Pro Leu Thr Gln Arg
            180                 185                 190         
Gly Phe Tyr Val Ala Phe Gln Asp Thr Gly Ala Cys Leu Ala Leu Val
        195                 200                 205             
Ala Val Arg Leu Phe Ser Tyr Thr Cys Pro Ala Val Leu Arg Ser Phe
    210                 215                 220                 
Ala Ser Phe Pro Glu Thr Gln Ala Ser Gly Ala Gly Gly Ala Ser Leu
225                 230                 235                 240 
Val Ala Ala Val Gly Thr Cys Val Ala His Ala Glu Pro Glu Glu Asp
                245                 250                 255     
Gly Val Gly Gly Gln Ala Gly Gly Ser Pro Pro Arg Leu His Cys Asn
            260                 265                 270         
Gly Glu Gly Lys Trp Met Val Ala Val Gly Gly Cys Arg Cys Gln Pro
        275                 280                 285             
Gly Tyr Gln Pro Ala Arg Gly Asp Lys Ala Cys Gln Ala Cys Pro Arg
    290                 295                 300                 
Gly Leu Tyr Lys Ser Ser Ala Gly Asn Ala Pro Cys Ser Pro Cys Pro
305                 310                 315                 320 
Ala Arg Ser His Ala Pro Asn Pro Ala Ala Pro Val Cys Pro Cys Leu
                325                 330                 335     
Glu Gly Phe Tyr Arg Ala Ser Ser Asp Pro Pro Glu Ala Pro Cys Thr
            340                 345                 350         
Gly Pro Pro Ser Ala Pro Gln Glu Leu Trp Phe Glu Val Gln Gly Ser
        355                 360                 365             
Ala Leu Met Leu His Trp Arg Leu Pro Arg Glu Leu Gly Gly Arg Gly
    370                 375                 380                 
Asp Leu Leu Phe Asn Val Val Cys Lys Glu Cys Glu Gly Arg Gln Glu
385                 390                 395                 400 
Pro Ala Ser Gly Gly Gly Gly Thr Cys His Arg Cys Arg Asp Glu Val
                405                 410                 415     
His Phe Asp Pro Arg Gln Arg Gly Leu Thr Glu Ser Arg Val Leu Val
            420                 425                 430         
Gly Gly Leu Arg Ala His Val Pro Tyr Ile Leu Glu Val Gln Ala Val
        435                 440                 445             
Asn Gly Val Ser Glu Leu Ser Pro Asp Pro Pro Gln Ala Ala Ala Ile
    450                 455                 460                 
Asn Val Ser Thr Ser His Glu Val Pro Ser Ala Val Pro Val Val His
465                 470                 475                 480 
Gln Val Ser Arg Ala Ser Asn Ser Ile Thr Val Ser Trp Pro Gln Pro
                485                 490                 495     
Asp Gln Thr Asn Gly Asn Ile Leu Asp Tyr Gln Leu Arg Tyr Tyr Asp
            500                 505                 510         
Gln Ala Glu Asp Glu Ser His Ser Phe Thr Leu Thr Ser Glu Thr Asn
        515                 520                 525             
Thr Ala Thr Val Thr Gln Leu Ser Pro Gly His Ile Tyr Gly Phe Gln
    530                 535                 540                 
Val Arg Ala Arg Thr Ala Ala Gly His Gly Pro Tyr Gly Gly Lys Val
545                 550                 555                 560 
Tyr Phe Gln Thr Leu Pro Gln Gly Glu Leu Ser Ser Gln Leu Pro Glu
                565                 570                 575     
Arg Leu Ser Leu Val Ile Gly Ser Ile Leu Gly Ala Leu Ala Phe Leu
            580                 585                 590         
Leu Leu Ala Ala Ile Thr Val Leu Ala Val Val Phe Gln Arg Lys Arg
        595                 600                 605             
Arg Gly Thr Gly Tyr Thr Glu Gln Leu Gln Gln Tyr Ser Ser Pro Gly
    610                 615                 620                 
Leu Gly Val Lys Tyr Tyr Ile Asp Pro Ser Thr Tyr Glu Asp Pro Cys
625                 630                 635                 640 
Gln Ala Ile Arg Glu Leu Ala Arg Glu Val Asp Pro Ala Tyr Ile Lys
                645                 650                 655     
Ile Glu Glu Val Ile Gly Thr Gly Ser Phe Gly Glu Val Arg Gln Gly
            660                 665                 670         
Arg Leu Gln Pro Arg Gly Arg Arg Glu Gln Thr Val Ala Ile Gln Ala
        675                 680                 685             
Leu Trp Ala Gly Gly Ala Glu Ser Leu Gln Met Thr Phe Leu Gly Arg
    690                 695                 700                 
Ala Ala Val Leu Gly Gln Phe Gln His Pro Asn Ile Leu Arg Leu Glu
705                 710                 715                 720 
Gly Val Val Thr Lys Ser Arg Pro Leu Met Val Leu Thr Glu Phe Met
                725                 730                 735     
Glu Leu Gly Pro Leu Asp Ser Phe Leu Arg Gln Arg Glu Gly Gln Phe
            740                 745                 750         
Ser Ser Leu Gln Leu Val Ala Met Gln Arg Gly Val Ala Ala Ala Met
        755                 760                 765             
Gln Tyr Leu Ser Ser Phe Ala Phe Val His Arg Ser Leu Ser Ala His
    770                 775                 780                 
Ser Val Leu Val Asn Ser His Leu Val Cys Lys Val Ala Arg Leu Gly
785                 790                 795                 800 
His Ser Pro Gln Gly Pro Ser Cys Leu Leu Arg Trp Ala Ala Pro Glu
                805                 810                 815     
Val Ile Ala His Gly Lys His Thr Thr Ser Ser Asp Val Trp Ser Phe
            820                 825                 830         
Gly Ile Leu Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp
        835                 840                 845             
Asp Met Ser Glu Gln Glu Val Leu Asn Ala Ile Glu Gln Glu Phe Arg
    850                 855                 860                 
Leu Pro Pro Pro Pro Gly Cys Pro Pro Gly Leu His Leu Leu Met Leu
865                 870                 875                 880 
Asp Thr Trp Gln Lys Asp Arg Ala Arg Arg Pro His Phe Asp Gln Leu
                885                 890                 895     
Val Ala Ala Phe Asp Lys Met Ile Arg Lys Pro Asp Thr Leu Gln Ala
            900                 905                 910         
Gly Gly Asp Pro Gly Glu Arg Pro Ser Gln Ala Leu Leu Thr Pro Val
        915                 920                 925             
Ala Leu Asp Phe Pro Cys Leu Asp Ser Pro Gln Ala Trp Leu Ser Ala
    930                 935                 940                 
Ile Gly Leu Glu Cys Tyr Gln Asp Asn Phe Ser Lys Phe Gly Leu Cys
945                 950                 955                 960 
Thr Phe Ser Asp Val Ala Gln Leu Ser Leu Glu Asp Leu Pro Ala Leu
                965                 970                 975     
Gly Ile Thr Leu Ala Gly His Gln Lys Lys Leu Leu His His Ile Gln
            980                 985                 990         
Leu Leu Gln Gln His Leu Arg Gln Gln Gly Ser Val Glu Val
        995                 1000                1005    

<210> 407
<211> 1210
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP005219
<309> 2004-01-26  

<400> 407
Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala
 1               5                  10                  15      
Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln
            20                  25                  30          
Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe
        35                  40                  45              
Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn
    50                  55                  60                  
Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys
65                  70                  75                  80  
Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val
                85                  90                  95      
Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr
            100                 105                 110         
Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn
        115                 120                 125             
Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu
    130                 135                 140                 
His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu
145                 150                 155                 160 
Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met
                165                 170                 175     
Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro
            180                 185                 190         
Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln
        195                 200                 205             
Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg
    210                 215                 220                 
Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys
225                 230                 235                 240 
Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp
                245                 250                 255     
Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro
            260                 265                 270         
Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly
        275                 280                 285             
Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His
    290                 295                 300                 
Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu
305                 310                 315                 320 
Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val
                325                 330                 335     
Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn
            340                 345                 350         
Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp
        355                 360                 365             
Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr
    370                 375                 380                 
Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu
385                 390                 395                 400 
Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp
                405                 410                 415     
Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln
            420                 425                 430         
His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu
        435                 440                 445             
Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser
    450                 455                 460                 
Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu
465                 470                 475                 480 
Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu
                485                 490                 495     
Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro
            500                 505                 510         
Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn
        515                 520                 525             
Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly
    530                 535                 540                 
Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro
545                 550                 555                 560 
Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro
                565                 570                 575     
Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val
            580                 585                 590         
Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp
        595                 600                 605             
Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys
    610                 615                 620                 
Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly
625                 630                 635                 640 
Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu
                645                 650                 655     
Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His
            660                 665                 670         
Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu
        675                 680                 685             
Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu
    690                 695                 700                 
Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser
705                 710                 715                 720 
Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu
                725                 730                 735     
Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser
            740                 745                 750         
Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser
        755                 760                 765             
Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser
    770                 775                 780                 
Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp
785                 790                 795                 800 
Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn
                805                 810                 815     
Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg
            820                 825                 830         
Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro
        835                 840                 845             
Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala
    850                 855                 860                 
Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp
865                 870                 875                 880 
Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp
                885                 890                 895     
Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser
            900                 905                 910         
Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu
        915                 920                 925             
Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr
    930                 935                 940                 
Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys
945                 950                 955                 960 
Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln
                965                 970                 975     
Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro
            980                 985                 990         
Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met Asp
        995                 1000                1005            
Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe
    1010                1015                1020                
Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser Ala
1025                1030                1035                1040
Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu Gln
                1045                1050                1055    
Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg Tyr Ser Ser Asp
            1060                1065                1070        
Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp Asp Thr Phe Leu Pro
        1075                1080                1085            
Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly Ser
    1090                1095                1100                
Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro Ser
1105                1110                1115                1120
Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala Val Gly Asn Pro
                1125                1130                1135    
Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn Ser Thr Phe Asp
            1140                1145                1150        
Ser Pro Ala His Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu Asp
        1155                1160                1165            
Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn
    1170                1175                1180                
Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val
1185                1190                1195                1200
Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala
                1205                1210

<210> 408
<211> 1255
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP004439
<309> 2004-12-20  

<400> 408
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu
            340                 345                 350         
Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys
        355                 360                 365             
Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp
    370                 375                 380                 
Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe
385                 390                 395                 400 
Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro
                405                 410                 415     
Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg
            420                 425                 430         
Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu
        435                 440                 445             
Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly
    450                 455                 460                 
Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val
465                 470                 475                 480 
Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr
                485                 490                 495     
Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His
            500                 505                 510         
Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys
        515                 520                 525             
Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys
    530                 535                 540                 
Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys
545                 550                 555                 560 
Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys
                565                 570                 575     
Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp
            580                 585                 590         
Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu
        595                 600                 605             
Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln
    610                 615                 620                 
Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys
625                 630                 635                 640 
Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser
                645                 650                 655     
Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly
            660                 665                 670         
Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg
        675                 680                 685             
Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly
    690                 695                 700                 
Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu
705                 710                 715                 720 
Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys
                725                 730                 735     
Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile
            740                 745                 750         
Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu
        755                 760                 765             
Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg
    770                 775                 780                 
Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu
785                 790                 795                 800 
Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg
                805                 810                 815     
Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly
            820                 825                 830         
Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala
        835                 840                 845             
Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe
    850                 855                 860                 
Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp
865                 870                 875                 880 
Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg
                885                 890                 895     
Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val
            900                 905                 910         
Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala
        915                 920                 925             
Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro
    930                 935                 940                 
Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met
945                 950                 955                 960 
Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe
                965                 970                 975     
Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu
            980                 985                 990         
Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu
        995                 1000                1005            
Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr Leu
    1010                1015                1020                
Val Pro Gln Gln Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly Ala Gly
1025                1030                1035                1040
Gly Met Val His His Arg His Arg Ser Ser Ser Thr Arg Ser Gly Gly
                1045                1050                1055    
Gly Asp Leu Thr Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala Pro Arg
            1060                1065                1070        
Ser Pro Leu Ala Pro Ser Glu Gly Ala Gly Ser Asp Val Phe Asp Gly
        1075                1080                1085            
Asp Leu Gly Met Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro Thr His
    1090                1095                1100                
Asp Pro Ser Pro Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val Pro Leu
1105                1110                1115                1120
Pro Ser Glu Thr Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser Pro Gln
                1125                1130                1135    
Pro Glu Tyr Val Asn Gln Pro Asp Val Arg Pro Gln Pro Pro Ser Pro
            1140                1145                1150        
Arg Glu Gly Pro Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu
        1155                1160                1165            
Arg Pro Lys Thr Leu Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val
    1170                1175                1180                
Phe Ala Phe Gly Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln
1185                1190                1195                1200
Gly Gly Ala Ala Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala
                1205                1210                1215    
Phe Asp Asn Leu Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala
            1220                1225                1230        
Pro Pro Ser Thr Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr
        1235                1240                1245            
Leu Gly Leu Asp Val Pro Val
    1250                1255


<210> 409
<211> 1342
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP001973
<309> 2004-12-20  

<400> 409
Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu
 1               5                  10                  15      
Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr
            20                  25                  30          
Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr
        35                  40                  45              
Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60                  
Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile
65                  70                  75                  80  
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr
                85                  90                  95      
Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp
            100                 105                 110         
Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser
        115                 120                 125             
His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser
    130                 135                 140                 
Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr
145                 150                 155                 160 
Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val
                165                 170                 175     
Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly
            180                 185                 190         
Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr
        195                 200                 205             
Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn
    210                 215                 220                 
Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp
225                 230                 235                 240 
Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val
                245                 250                 255     
Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu
            260                 265                 270         
Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala
        275                 280                 285             
Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala
    290                 295                 300                 
Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys
305                 310                 315                 320 
Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser
                325                 330                 335     
Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val
            340                 345                 350         
Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu
        355                 360                 365             
Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu
    370                 375                 380                 
Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln
385                 390                 395                 400 
Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr
                405                 410                 415     
Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile
            420                 425                 430         
Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu
        435                 440                 445             
Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr
    450                 455                 460                 
His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu
465                 470                 475                 480 
Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu
                485                 490                 495     
Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro
            500                 505                 510         
Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val
        515                 520                 525             
Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala
    530                 535                 540                 
His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu
545                 550                 555                 560 
Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys
                565                 570                 575     
Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly
            580                 585                 590         
Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn
        595                 600                 605             
Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro
    610                 615                 620                 
Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr
625                 630                 635                 640 
His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe
                645                 650                 655     
Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln
            660                 665                 670         
Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu
        675                 680                 685             
Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe
    690                 695                 700                 
Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe
705                 710                 715                 720 
Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys
                725                 730                 735     
Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser
            740                 745                 750         
Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His
        755                 760                 765             
Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln
    770                 775                 780                 
Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg
785                 790                 795                 800 
Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val
                805                 810                 815     
Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His
            820                 825                 830         
Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val
        835                 840                 845             
Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys
    850                 855                 860                 
Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu
865                 870                 875                 880 
Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser
                885                 890                 895     
Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr
            900                 905                 910         
Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu
        915                 920                 925             
Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met
    930                 935                 940                 
Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu
945                 950                 955                 960 
Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu
                965                 970                 975     
Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro
            980                 985                 990         
His Gly Leu Thr Asn Lys Lys Leu Glu Glu Val Glu Leu Glu Pro Glu
        995                 1000                1005            
Leu Asp Leu Asp Leu Asp Leu Glu Ala Glu Glu Asp Asn Leu Ala Thr
    1010                1015                1020                
Thr Thr Leu Gly Ser Ala Leu Ser Leu Pro Val Gly Thr Leu Asn Arg
1025                1030                1035                1040
Pro Arg Gly Ser Gln Ser Leu Leu Ser Pro Ser Ser Gly Tyr Met Pro
                1045                1050                1055    
Met Asn Gln Gly Asn Leu Gly Glu Ser Cys Gln Glu Ser Ala Val Ser
            1060                1065                1070        
Gly Ser Ser Glu Arg Cys Pro Arg Pro Val Ser Leu His Pro Met Pro
        1075                1080                1085            
Arg Gly Cys Leu Ala Ser Glu Ser Ser Glu Gly His Val Thr Gly Ser
    1090                1095                1100                
Glu Ala Glu Leu Gln Glu Lys Val Ser Met Cys Arg Ser Arg Ser Arg
1105                1110                1115                1120
Ser Arg Ser Pro Arg Pro Arg Gly Asp Ser Ala Tyr His Ser Gln Arg
                1125                1130                1135    
His Ser Leu Leu Thr Pro Val Thr Pro Leu Ser Pro Pro Gly Leu Glu
            1140                1145                1150        
Glu Glu Asp Val Asn Gly Tyr Val Met Pro Asp Thr His Leu Lys Gly
        1155                1160                1165            
Thr Pro Ser Ser Arg Glu Gly Thr Leu Ser Ser Val Gly Leu Ser Ser
    1170                1175                1180                
Val Leu Gly Thr Glu Glu Glu Asp Glu Asp Glu Glu Tyr Glu Tyr Met
1185                1190                1195                1200
Asn Arg Arg Arg Arg His Ser Pro Pro His Pro Pro Arg Pro Ser Ser
                1205                1210                1215    
Leu Glu Glu Leu Gly Tyr Glu Tyr Met Asp Val Gly Ser Asp Leu Ser
            1220                1225                1230        
Ala Ser Leu Gly Ser Thr Gln Ser Cys Pro Leu His Pro Val Pro Ile
        1235                1240                1245            
Met Pro Thr Ala Gly Thr Thr Pro Asp Glu Asp Tyr Glu Tyr Met Asn
    1250                1255                1260                
Arg Gln Arg Asp Gly Gly Gly Pro Gly Gly Asp Tyr Ala Ala Met Gly
1265                1270                1275                1280
Ala Cys Pro Ala Ser Glu Gln Gly Tyr Glu Glu Met Arg Ala Phe Gln
                1285                1290                1295    
Gly Pro Gly His Gln Ala Pro His Val His Tyr Ala Arg Leu Lys Thr
            1300                1305                1310        
Leu Arg Ser Leu Glu Ala Thr Asp Ser Ala Phe Asp Asn Pro Asp Tyr
        1315                1320                1325            
Trp His Ser Arg Leu Phe Pro Lys Ala Asn Ala Gln Arg Thr
    1330                1335                1340        


<210> 410
<211> 820
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. AAA35835
<309> 2001-12-14  

<400> 410
Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala
 1               5                  10                  15      
Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln
            20                  25                  30          
Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly
        35                  40                  45              
Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile
    50                  55                  60                  
Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg
65                  70                  75                  80  
Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser
                85                  90                  95      
Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr
            100                 105                 110         
Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp
        115                 120                 125             
Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr
    130                 135                 140                 
Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu
145                 150                 155                 160 
Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys
                165                 170                 175     
Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn Ser
            180                 185                 190         
Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val Arg Tyr
        195                 200                 205             
Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp Lys Gly
    210                 215                 220                 
Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr
225                 230                 235                 240 
Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln
                245                 250                 255     
Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn Val Glu
            260                 265                 270         
Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln Trp Leu
        275                 280                 285             
Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro
    290                 295                 300                 
Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp Lys Glu
305                 310                 315                 320 
Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala Gly Glu
                325                 330                 335     
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His Ser Ala
            340                 345                 350         
Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val Met Thr
        355                 360                 365             
Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala Phe Leu
    370                 375                 380                 
Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys Ser Gly
385                 390                 395                 400 
Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys Leu Ala
                405                 410                 415     
Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp Ser Ser
            420                 425                 430         
Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser
        435                 440                 445             
Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro
    450                 455                 460                 
Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys
465                 470                 475                 480 
Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile
                485                 490                 495     
Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala Val Lys
            500                 505                 510         
Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser
        515                 520                 525             
Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn
    530                 535                 540                 
Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu
545                 550                 555                 560 
Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro
                565                 570                 575     
Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu Glu Gln
            580                 585                 590         
Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly
        595                 600                 605             
Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala
    610                 615                 620                 
Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe
625                 630                 635                 640 
Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr
                645                 650                 655     
Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp
            660                 665                 670         
Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
        675                 680                 685             
Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val
    690                 695                 700                 
Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro
705                 710                 715                 720 
Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His
                725                 730                 735     
Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu
            740                 745                 750         
Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser
        755                 760                 765             
Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser
    770                 775                 780                 
Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro
785                 790                 795                 800 
Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn Gly Gly
                805                 810                 815     
Leu Lys Arg Arg
            820 


<210> 411
<211> 821
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP000132
<309> 2004-12-20  

<400> 411
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu
        35                  40                  45              
Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu
    50                  55                  60                  
Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly
65                  70                  75                  80  
Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly
                85                  90                  95      
Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr
            100                 105                 110         
Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile
        115                 120                 125             
Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val
    130                 135                 140                 
Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu
145                 150                 155                 160 
Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys
                165                 170                 175     
Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu
            180                 185                 190         
Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys
        195                 200                 205             
Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser
    210                 215                 220                 
Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile
225                 230                 235                 240 
Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro
                245                 250                 255     
Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly
            260                 265                 270         
Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile
        275                 280                 285             
Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp
    290                 295                 300                 
Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr
305                 310                 315                 320 
Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp
                325                 330                 335     
Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe
            340                 345                 350         
His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu
        355                 360                 365             
Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly
    370                 375                 380                 
Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met
385                 390                 395                 400 
Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His
                405                 410                 415     
Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala
            420                 425                 430         
Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr
        435                 440                 445             
Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser
    450                 455                 460                 
Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys
465                 470                 475                 480 
Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val
                485                 490                 495     
Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val
            500                 505                 510         
Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu
        515                 520                 525             
Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His
    530                 535                 540                 
Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu
545                 550                 555                 560 
Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu
                565                 570                 575     
Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg
            580                 585                 590         
Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr
        595                 600                 605             
Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His
    610                 615                 620                 
Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met
625                 630                 635                 640 
Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr
                645                 650                 655     
Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro
            660                 665                 670         
Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser
        675                 680                 685             
Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr
    690                 695                 700                 
Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His
705                 710                 715                 720 
Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met
                725                 730                 735     
Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln
            740                 745                 750         
Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu
        755                 760                 765             
Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro
    770                 775                 780                 
Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro
785                 790                 795                 800 
Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn
                805                 810                 815     
Gly Ser Val Lys Thr
            820     


<210> 412
<211> 806
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP000133
<309> 2004-12-20  

<400> 412
Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile
 1               5                  10                  15      
Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val
            20                  25                  30          
Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln
        35                  40                  45              
Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro
    50                  55                  60                  
Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly
65                  70                  75                  80  
Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val
                85                  90                  95      
Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg
            100                 105                 110         
Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala
        115                 120                 125             
Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr
    130                 135                 140                 
Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp
145                 150                 155                 160 
Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys
                165                 170                 175     
Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly
            180                 185                 190         
Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His
        195                 200                 205             
Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly
    210                 215                 220                 
Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr
225                 230                 235                 240 
Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln
                245                 250                 255     
Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu
            260                 265                 270         
Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu
        275                 280                 285             
Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro
    290                 295                 300                 
Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu
305                 310                 315                 320 
Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu
                325                 330                 335     
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala
            340                 345                 350         
Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu
        355                 360                 365             
Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe
    370                 375                 380                 
Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser
385                 390                 395                 400 
Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg
                405                 410                 415     
Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser Met Ser
            420                 425                 430         
Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly
        435                 440                 445             
Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys
    450                 455                 460                 
Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu
465                 470                 475                 480 
Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys
                485                 490                 495     
Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp
            500                 505                 510         
Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met
        515                 520                 525             
Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala
    530                 535                 540                 
Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys
545                 550                 555                 560 
Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp
                565                 570                 575     
Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys
            580                 585                 590         
Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu
        595                 600                 605             
Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu
    610                 615                 620                 
Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg
625                 630                 635                 640 
Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu
                645                 650                 655     
Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr
            660                 665                 670         
His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe
        675                 680                 685             
Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe
    690                 695                 700                 
Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr
705                 710                 715                 720 
His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser
                725                 730                 735     
Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu
            740                 745                 750         
Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu
        755                 760                 765             
Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly
    770                 775                 780                 
Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser
785                 790                 795                 800 
Ser Gly Gly Ser Arg Thr
                805     


<210> 413
<211> 802
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP002002
<309> 2004-10-28  

<400> 413
Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly
 1               5                  10                  15      
Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro
            20                  25                  30          
Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala
        35                  40                  45              
Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly
    50                  55                  60                  
His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg
65                  70                  75                  80  
Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala
                85                  90                  95      
Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn
            100                 105                 110         
Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu
        115                 120                 125             
Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln
    130                 135                 140                 
Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His
145                 150                 155                 160 
Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly
                165                 170                 175     
Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His
            180                 185                 190         
Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser
        195                 200                 205             
Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys
    210                 215                 220                 
Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp
225                 230                 235                 240 
Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro
                245                 250                 255     
Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys
            260                 265                 270         
Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val
        275                 280                 285             
Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val
    290                 295                 300                 
Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu
305                 310                 315                 320 
Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly
                325                 330                 335     
Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro
            340                 345                 350         
Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr
        355                 360                 365             
Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu
    370                 375                 380                 
Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro
385                 390                 395                 400 
Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg
                405                 410                 415     
Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu
            420                 425                 430         
Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly
        435                 440                 445             
Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg
    450                 455                 460                 
Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln
465                 470                 475                 480 
Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln
                485                 490                 495     
Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys
            500                 505                 510         
Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly
        515                 520                 525             
Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly
    530                 535                 540                 
Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu
545                 550                 555                 560 
Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly
                565                 570                 575     
Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys
            580                 585                 590         
Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys
        595                 600                 605             
Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn
    610                 615                 620                 
Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile
625                 630                 635                 640 
Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met
                645                 650                 655     
Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val
            660                 665                 670         
Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser
        675                 680                 685             
Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu
    690                 695                 700                 
Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly
705                 710                 715                 720 
Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe
                725                 730                 735     
Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu
            740                 745                 750         
Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly
        755                 760                 765             
Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His
    770                 775                 780                 
Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val
785                 790                 795                 800 
Gln Thr
        
<210> 414
<211> 1390
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP000236
<309> 2004-10-28  

<400> 414
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480 
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510         
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525             
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540                 
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560 
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575     
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590         
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605             
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620                 
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640 
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
                645                 650                 655     
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly
            660                 665                 670         
Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg
        675                 680                 685             
His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn
    690                 695                 700                 
Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe
705                 710                 715                 720 
Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe
                725                 730                 735     
Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser
            740                 745                 750         
Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn
        755                 760                 765             
Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg
    770                 775                 780                 
Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys
785                 790                 795                 800 
Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys
                805                 810                 815     
Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp
            820                 825                 830         
Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val
        835                 840                 845             
Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp
    850                 855                 860                 
Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys
865                 870                 875                 880 
Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val
                885                 890                 895     
Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys
            900                 905                 910         
Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp
        915                 920                 925             
Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala
    930                 935                 940                 
Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln
945                 950                 955                 960 
Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His
                965                 970                 975     
Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr
            980                 985                 990         
Thr Glu Met Val Ser Asn Glu Ser Val Asp Tyr Arg Ala Thr Phe Pro
        995                 1000                1005            
Glu Asp Gln Phe Pro Asn Ser Ser Gln Asn Gly Ser Cys Arg Gln Val
    1010                1015                1020                
Gln Tyr Pro Leu Thr Asp Met Ser Pro Ile Leu Thr Ser Gly Asp Ser
1025                1030                1035                1040
Asp Ile Ser Ser Pro Leu Leu Gln Asn Thr Val His Ile Asp Leu Ser
                1045                1050                1055    
Ala Leu Asn Pro Glu Leu Val Gln Ala Val Gln His Val Val Ile Gly
            1060                1065                1070        
Pro Ser Ser Leu Ile Val His Phe Asn Glu Val Ile Gly Arg Gly His
        1075                1080                1085            
Phe Gly Cys Val Tyr His Gly Thr Leu Leu Asp Asn Asp Gly Lys Lys
    1090                1095                1100                
Ile His Cys Ala Val Lys Ser Leu Asn Arg Ile Thr Asp Ile Gly Glu
1105                1110                1115                1120
Val Ser Gln Phe Leu Thr Glu Gly Ile Ile Met Lys Asp Phe Ser His
                1125                1130                1135    
Pro Asn Val Leu Ser Leu Leu Gly Ile Cys Leu Arg Ser Glu Gly Ser
            1140                1145                1150        
Pro Leu Val Val Leu Pro Tyr Met Lys His Gly Asp Leu Arg Asn Phe
        1155                1160                1165            
Ile Arg Asn Glu Thr His Asn Pro Thr Val Lys Asp Leu Ile Gly Phe
    1170                1175                1180                
Gly Leu Gln Val Ala Lys Gly Met Lys Tyr Leu Ala Ser Lys Lys Phe
1185                1190                1195                1200
Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asp Glu Lys Phe
                1205                1210                1215    
Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Asp Met Tyr Asp Lys
            1220                1225                1230        
Glu Tyr Tyr Ser Val His Asn Lys Thr Gly Ala Lys Leu Pro Val Lys
        1235                1240                1245            
Trp Met Ala Leu Glu Ser Leu Gln Thr Gln Lys Phe Thr Thr Lys Ser
    1250                1255                1260                
Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Leu Met Thr Arg Gly
1265                1270                1275                1280
Ala Pro Pro Tyr Pro Asp Val Asn Thr Phe Asp Ile Thr Val Tyr Leu
                1285                1290                1295    
Leu Gln Gly Arg Arg Leu Leu Gln Pro Glu Tyr Cys Pro Asp Pro Leu
            1300                1305                1310        
Tyr Glu Val Met Leu Lys Cys Trp His Pro Lys Ala Glu Met Arg Pro
        1315                1320                1325            
Ser Phe Ser Glu Leu Val Ser Arg Ile Ser Ala Ile Phe Ser Thr Phe
    1330                1335                1340                
Ile Gly Glu His Tyr Val His Val Asn Ala Thr Tyr Val Asn Val Lys
1345                1350                1355                1360
Cys Val Ala Pro Tyr Pro Ser Leu Leu Ser Ser Glu Asp Asn Ala Asp
                1365                1370                1375    
Asp Glu Val Asp Thr Arg Pro Ala Ser Phe Trp Glu Thr Ser
            1380                1385                1390

<210> 415
<211> 1400
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP002438
<309> 2004-10-28  

<400> 415
Met Glu Leu Leu Pro Pro Leu Pro Gln Ser Phe Leu Leu Leu Leu Leu
 1               5                  10                  15      
Leu Pro Ala Lys Pro Ala Ala Gly Glu Asp Trp Gln Cys Pro Arg Thr
            20                  25                  30          
Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val Lys Tyr Val Val Pro Ser
        35                  40                  45              
Phe Ser Ala Gly Gly Leu Val Gln Ala Met Val Thr Tyr Glu Gly Asp
    50                  55                  60                  
Arg Asn Glu Ser Ala Val Phe Val Ala Ile Arg Asn Arg Leu His Val
65                  70                  75                  80  
Leu Gly Pro Asp Leu Lys Ser Val Gln Ser Leu Ala Thr Gly Pro Ala
                85                  90                  95      
Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala Cys Gly Pro Gly Pro His
            100                 105                 110         
Gly Pro Pro Gly Asp Thr Asp Thr Lys Val Leu Val Leu Asp Pro Ala
        115                 120                 125             
Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe
    130                 135                 140                 
Leu His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro
145                 150                 155                 160 
Ala Cys Leu Phe Ser Ala His His Asn Arg Pro Asp Asp Cys Pro Asp
                165                 170                 175     
Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln Gly
            180                 185                 190         
Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Ala Ala Val Ala
        195                 200                 205             
Gly Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ala Asp
    210                 215                 220                 
Ala Ser Gly Phe Ala Pro Gly Phe Val Ala Leu Ser Val Leu Pro Lys
225                 230                 235                 240 
His Leu Val Ser Tyr Ser Ile Glu Tyr Val His Ser Phe His Thr Gly
                245                 250                 255     
Ala Phe Val Tyr Phe Leu Thr Val Gln Pro Ala Ser Val Thr Asp Asp
            260                 265                 270         
Pro Ser Ala Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro
        275                 280                 285             
Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys Arg Phe Ala Pro
    290                 295                 300                 
Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Gly Gln Pro Tyr Pro Val
305                 310                 315                 320 
Leu Gln Val Ala His Ser Ala Pro Val Gly Ala Gln Leu Ala Thr Glu
                325                 330                 335     
Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val Thr
            340                 345                 350         
Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn Ser Val Val Cys Ala
        355                 360                 365             
Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp Glu Gly Val Glu Arg
    370                 375                 380                 
Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg Arg Gly Leu Asp Phe
385                 390                 395                 400 
Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Pro Gly Leu Glu Ala Leu
                405                 410                 415     
Ser Pro Asn Thr Ser Cys Arg His Phe Pro Leu Leu Val Ser Ser Ser
            420                 425                 430         
Phe Ser Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Pro Val Gln Val
        435                 440                 445             
Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn Val Thr Val Ala His Met
    450                 455                 460                 
Gly Thr Met Asp Gly Arg Ile Leu Gln Val Glu Leu Val Arg Ser Leu
465                 470                 475                 480 
Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Asp Ser Gly Gln
                485                 490                 495     
Pro Val Gln Arg Asp Val Ser Arg Leu Gly Asp His Leu Leu Phe Ala
            500                 505                 510         
Ser Gly Asp Gln Val Phe Gln Val Pro Ile Arg Gly Pro Gly Cys Arg
        515                 520                 525             
His Phe Leu Thr Cys Gly Arg Cys Leu Arg Ala Trp His Phe Met Gly
    530                 535                 540                 
Cys Gly Trp Cys Gly Asn Met Cys Gly Gln Gln Lys Glu Cys Pro Gly
545                 550                 555                 560 
Ser Trp Gln Gln Asp His Cys Pro Pro Lys Leu Thr Glu Phe His Pro
                565                 570                 575     
His Ser Gly Pro Leu Arg Gly Ser Thr Arg Leu Thr Leu Cys Gly Ser
            580                 585                 590         
Asn Phe Tyr Leu His Pro Ser Gly Leu Val Pro Glu Gly Thr His Gln
        595                 600                 605             
Val Thr Val Gly Gln Ser Pro Cys Arg Pro Leu Pro Lys Asp Ser Ser
    610                 615                 620                 
Lys Leu Arg Pro Val Pro Arg Lys Asp Phe Val Glu Glu Phe Glu Cys
625                 630                 635                 640 
Glu Leu Glu Pro Leu Gly Thr Gln Ala Val Gly Pro Thr Asn Val Ser
                645                 650                 655     
Leu Thr Val Thr Asn Met Pro Pro Gly Lys His Phe Arg Val Asp Gly
            660                 665                 670         
Thr Ser Val Leu Arg Gly Phe Ser Phe Met Glu Pro Val Leu Ile Ala
        675                 680                 685             
Val Gln Pro Leu Phe Gly Pro Arg Ala Gly Gly Thr Cys Leu Thr Leu
    690                 695                 700                 
Glu Gly Gln Ser Leu Ser Val Gly Thr Ser Arg Ala Val Leu Val Asn
705                 710                 715                 720 
Gly Thr Glu Cys Leu Leu Ala Arg Val Ser Glu Gly Gln Leu Leu Cys
                725                 730                 735     
Ala Thr Pro Pro Gly Ala Thr Val Ala Ser Val Pro Leu Ser Leu Gln
            740                 745                 750         
Val Gly Gly Ala Gln Val Pro Gly Ser Trp Thr Phe Gln Tyr Arg Glu
        755                 760                 765             
Asp Pro Val Val Leu Ser Ile Ser Pro Asn Cys Gly Tyr Ile Asn Ser
    770                 775                 780                 
His Ile Thr Ile Cys Gly Gln His Leu Thr Ser Ala Trp His Leu Val
785                 790                 795                 800 
Leu Ser Phe His Asp Gly Leu Arg Ala Val Glu Ser Arg Cys Glu Arg
                805                 810                 815     
Gln Leu Pro Glu Gln Gln Leu Cys Arg Leu Pro Glu Tyr Val Val Arg
            820                 825                 830         
Asp Pro Gln Gly Trp Val Ala Gly Asn Leu Ser Ala Arg Gly Asp Gly
        835                 840                 845             
Ala Ala Gly Phe Thr Leu Pro Gly Phe Arg Phe Leu Pro Pro Pro His
    850                 855                 860                 
Pro Pro Ser Ala Asn Leu Val Pro Leu Lys Pro Glu Glu His Ala Ile
865                 870                 875                 880 
Lys Phe Glu Tyr Ile Gly Leu Gly Ala Val Ala Asp Cys Val Gly Ile
                885                 890                 895     
Asn Val Thr Val Gly Gly Glu Ser Cys Gln His Glu Phe Arg Gly Asp
            900                 905                 910         
Met Val Val Cys Pro Leu Pro Pro Ser Leu Gln Leu Gly Gln Asp Gly
        915                 920                 925             
Ala Pro Leu Gln Val Cys Val Asp Gly Glu Cys His Ile Leu Gly Arg
    930                 935                 940                 
Val Val Arg Pro Gly Pro Asp Gly Val Pro Gln Ser Thr Leu Leu Gly
945                 950                 955                 960 
Ile Leu Leu Pro Leu Leu Leu Leu Val Ala Ala Leu Ala Thr Ala Leu
                965                 970                 975     
Val Phe Ser Tyr Trp Trp Arg Arg Lys Gln Leu Val Leu Pro Pro Asn
            980                 985                 990         
Leu Asn Asp Leu Ala Ser Leu Asp Gln Thr Ala Gly Ala Thr Pro Leu
        995                 1000                1005            
Pro Ile Leu Tyr Ser Gly Ser Asp Tyr Arg Ser Gly Leu Ala Leu Pro
    1010                1015                1020                
Ala Ile Asp Gly Leu Asp Ser Thr Thr Cys Val His Gly Ala Ser Phe
1025                1030                1035                1040
Ser Asp Ser Glu Asp Glu Ser Cys Val Pro Leu Leu Arg Lys Glu Ser
                1045                1050                1055    
Ile Gln Leu Arg Asp Leu Asp Ser Ala Leu Leu Ala Glu Val Lys Asp
            1060                1065                1070        
Val Leu Ile Pro His Glu Arg Val Val Thr His Ser Asp Arg Val Ile
        1075                1080                1085            
Gly Lys Gly His Phe Gly Val Val Tyr His Gly Glu Tyr Ile Asp Gln
    1090                1095                1100                
Ala Gln Asn Arg Ile Gln Cys Ala Ile Lys Ser Leu Ser Arg Ile Thr
1105                1110                1115                1120
Glu Met Gln Gln Val Glu Ala Phe Leu Arg Glu Gly Leu Leu Met Arg
                1125                1130                1135    
Gly Leu Asn His Pro Asn Val Leu Ala Leu Ile Gly Ile Met Leu Pro
            1140                1145                1150        
Pro Glu Gly Leu Pro His Val Leu Leu Pro Tyr Met Cys His Gly Asp
        1155                1160                1165            
Leu Leu Gln Phe Ile Arg Ser Pro Gln Arg Asn Pro Thr Val Lys Asp
    1170                1175                1180                
Leu Ile Ser Phe Gly Leu Gln Val Ala Arg Gly Met Glu Tyr Leu Ala
1185                1190                1195                1200
Glu Gln Lys Phe Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu
                1205                1210                1215    
Asp Glu Ser Phe Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Asp
            1220                1225                1230        
Ile Leu Asp Arg Glu Tyr Tyr Ser Val Gln Gln His Arg His Ala Arg
        1235                1240                1245            
Leu Pro Val Lys Trp Met Ala Leu Glu Ser Leu Gln Thr Tyr Arg Phe
    1250                1255                1260                
Thr Thr Lys Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Leu
1265                1270                1275                1280
Leu Thr Arg Gly Ala Pro Pro Tyr Arg His Ile Asp Pro Phe Asp Leu
                1285                1290                1295    
Thr His Phe Leu Ala Gln Gly Arg Arg Leu Pro Gln Pro Glu Tyr Cys
            1300                1305                1310        
Pro Asp Ser Leu Tyr Gln Val Met Gln Gln Cys Trp Glu Ala Asp Pro
        1315                1320                1325            
Ala Val Arg Pro Thr Phe Arg Val Leu Val Gly Glu Val Glu Gln Ile
    1330                1335                1340                
Val Ser Ala Leu Leu Gly Asp His Tyr Val Gln Leu Pro Ala Thr Tyr
1345                1350                1355                1360
Met Asn Leu Gly Pro Ser Thr Ser His Glu Met Asn Val Arg Pro Glu
                1365                1370                1375    
Gln Pro Gln Phe Ser Pro Met Pro Gly Asn Val Arg Arg Pro Arg Pro
            1380                1385                1390        
Leu Ser Glu Pro Pro Arg Pro Thr
        1395                1400

<210> 416
<211> 972
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP005202
<309> 2004-10-26  

<400> 416
Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His
 1               5                  10                  15      
Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val
            20                  25                  30          
Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val
        35                  40                  45              
Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly
    50                  55                  60                  
Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly
65                  70                  75                  80  
Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala
                85                  90                  95      
Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala
            100                 105                 110         
Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu
        115                 120                 125             
Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg
    130                 135                 140                 
Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His
145                 150                 155                 160 
Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln
                165                 170                 175     
Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg
            180                 185                 190         
Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val
        195                 200                 205             
Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys
    210                 215                 220                 
Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn
225                 230                 235                 240 
Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg
                245                 250                 255     
Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His
            260                 265                 270         
Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser
        275                 280                 285             
Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser
    290                 295                 300                 
Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn
305                 310                 315                 320 
Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp
                325                 330                 335     
Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala
            340                 345                 350         
Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu
        355                 360                 365             
Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg
    370                 375                 380                 
Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr
385                 390                 395                 400 
Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr
                405                 410                 415     
Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu
            420                 425                 430         
Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln
        435                 440                 445             
Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His
    450                 455                 460                 
Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn
465                 470                 475                 480 
Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp
                485                 490                 495     
Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu
            500                 505                 510         
Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu
        515                 520                 525             
Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro
    530                 535                 540                 
Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser
545                 550                 555                 560 
Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu
                565                 570                 575     
Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala
            580                 585                 590         
Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp
        595                 600                 605             
Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala
    610                 615                 620                 
Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu
625                 630                 635                 640 
Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly
                645                 650                 655     
Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu
            660                 665                 670         
Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser
        675                 680                 685             
Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu
    690                 695                 700                 
Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val
705                 710                 715                 720 
Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser
                725                 730                 735     
Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu
            740                 745                 750         
Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe
        755                 760                 765             
Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val
    770                 775                 780                 
Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala
785                 790                 795                 800 
Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg
                805                 810                 815     
Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr
            820                 825                 830         
Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile
        835                 840                 845             
Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys
    850                 855                 860                 
Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe
865                 870                 875                 880 
Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu
                885                 890                 895     
Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu
            900                 905                 910         
Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser
        915                 920                 925             
Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu
    930                 935                 940                 
Glu Ser Ser Ser Glu His Leu Thr Cys Cys Glu Gln Gly Asp Ile Ala
945                 950                 955                 960 
Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys
                965                 970         

<210> 417
<211> 993
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP004110
<309> 2005-01-22  

<400> 417
Met Pro Ala Leu Ala Arg Asp Ala Gly Thr Val Pro Leu Leu Val Val
 1               5                  10                  15      
Phe Ser Ala Met Ile Phe Gly Thr Ile Thr Asn Gln Asp Leu Pro Val
            20                  25                  30          
Ile Lys Cys Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val Gly
        35                  40                  45              
Lys Ser Ser Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly
    50                  55                  60                  
Cys Ala Leu Arg Pro Gln Ser Ser Gly Thr Val Tyr Glu Ala Ala Ala
65                  70                  75                  80  
Val Glu Val Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val Asp
                85                  90                  95      
Ala Pro Gly Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu
            100                 105                 110         
Asn Cys Gln Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser Met
        115                 120                 125             
Val Ile Leu Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu Phe
    130                 135                 140                 
Ile Gln Ser Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser Ile
145                 150                 155                 160 
Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met
                165                 170                 175     
Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro
            180                 185                 190         
Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu
        195                 200                 205             
Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu
    210                 215                 220                 
Phe Gly Thr Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu
225                 230                 235                 240 
Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr Thr
                245                 250                 255     
Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg Cys
            260                 265                 270         
Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu
        275                 280                 285             
Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser
    290                 295                 300                 
Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser Val
305                 310                 315                 320 
Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro
                325                 330                 335     
Ser Gln Ser Ala Leu Val Thr Ile Val Gly Lys Gly Phe Ile Asn Ala
            340                 345                 350         
Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe Cys
        355                 360                 365             
Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp Thr
    370                 375                 380                 
Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn Gly
385                 390                 395                 400 
Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu Tyr
                405                 410                 415     
Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe Thr
            420                 425                 430         
Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser
        435                 440                 445             
Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp
    450                 455                 460                 
Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu
465                 470                 475                 480 
Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val
                485                 490                 495     
Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val
            500                 505                 510         
Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu
        515                 520                 525             
Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser Phe
    530                 535                 540                 
Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr Leu
545                 550                 555                 560 
Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln Leu
                565                 570                 575     
Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr Val
            580                 585                 590         
Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg Glu
        595                 600                 605             
Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys Val
    610                 615                 620                 
Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile Gln
625                 630                 635                 640 
Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg Glu
                645                 650                 655     
Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His Glu
            660                 665                 670         
Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile Tyr
        675                 680                 685             
Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu Arg
    690                 695                 700                 
Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys Glu
705                 710                 715                 720 
His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser Ser
                725                 730                 735     
Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln Ile
            740                 745                 750         
Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu Tyr
        755                 760                 765             
Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu Thr
    770                 775                 780                 
Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met Glu
785                 790                 795                 800 
Phe Leu Glu Phe Lys Ser Cys Val His Arg Asp Leu Ala Ala Arg Asn
                805                 810                 815     
Val Leu Val Thr His Gly Lys Val Val Lys Ile Cys Asp Phe Gly Leu
            820                 825                 830         
Ala Arg Asp Ile Met Ser Asp Ser Asn Tyr Val Val Arg Gly Asn Ala
        835                 840                 845             
Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Leu Phe Glu Gly Ile
    850                 855                 860                 
Tyr Thr Ile Lys Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu
865                 870                 875                 880 
Ile Phe Ser Leu Gly Val Asn Pro Tyr Pro Gly Ile Pro Val Asp Ala
                885                 890                 895     
Asn Phe Tyr Lys Leu Ile Gln Asn Gly Phe Lys Met Asp Gln Pro Phe
            900                 905                 910         
Tyr Ala Thr Glu Glu Ile Tyr Ile Ile Met Gln Ser Cys Trp Ala Phe
        915                 920                 925             
Asp Ser Arg Lys Arg Pro Ser Phe Pro Asn Leu Thr Ser Phe Leu Gly
    930                 935                 940                 
Cys Gln Leu Ala Asp Ala Glu Glu Ala Met Tyr Gln Asn Val Asp Gly
945                 950                 955                 960 
Arg Val Ser Glu Cys Pro His Thr Tyr Gln Asn Arg Arg Pro Phe Ser
                965                 970                 975     
Arg Glu Met Asp Leu Gly Leu Leu Ser Pro Gln Ala Gln Val Glu Asp
            980                 985                 990         
Ser
    

<210> 418
<211> 1363
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP000213
<309> 2004-12-20  

<400> 418
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15      
Leu Leu Asp Gly Leu Val Ser Asp Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30          
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45              
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60                  
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80  
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95      
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110         
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125             
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140                 
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160 
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175     
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190         
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205             
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220                 
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240 
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255     
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270         
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285             
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300                 
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320 
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335     
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350         
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365             
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380                 
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400 
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415     
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430         
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445             
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460                 
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480 
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495     
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510         
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525             
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540                 
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560 
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575     
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590         
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605             
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620                 
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640 
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655     
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670         
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685             
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700                 
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720 
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735     
Arg Val Arg Glu Glu Asp Ala Gly Pro Tyr Leu Cys Ser Val Cys Arg
            740                 745                 750         
Pro Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765             
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780                 
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800 
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815     
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830         
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845             
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860                 
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880 
Leu Lys Glu Gly Ala Thr Ala Ser Glu Gln Arg Ala Leu Met Ser Glu
                885                 890                 895     
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910         
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925             
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940                 
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960 
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975     
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990         
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005            
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020                
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055    
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070        
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085            
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100                
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Val Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135    
Pro Glu Leu Ala Thr Pro Ala Ile Arg His Ile Met Leu Asn Cys Trp
            1140                1145                1150        
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Glu Leu Val Glu Ile
        1155                1160                1165            
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180                
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215    
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230        
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245            
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260                
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295    
Phe Ser Cys Lys Gly Pro Gly Gln Asn Val Ala Val Thr Arg Ala His
            1300                1305                1310        
Pro Asp Ser Gln Gly Arg Arg Arg Arg Pro Glu Arg Gly Ala Arg Gly
        1315                1320                1325            
Gly Gln Val Phe Tyr Asn Ser Glu Tyr Gly Glu Leu Ser Glu Pro Ser
    1330                1335                1340                
Glu Glu Asp His Cys Ser Pro Ser Ala Arg Val Thr Phe Phe Thr Asp
1345                1350                1355                1360
Asn Ser Tyr
            

<210> 419
<211> 1089
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP006197
<309> 2004-10-26  

<400> 419
Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr
 1               5                  10                  15      
Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro
            20                  25                  30          
Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg
        35                  40                  45              
Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu
    50                  55                  60                  
Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu
65                  70                  75                  80  
Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly
                85                  90                  95      
Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu
            100                 105                 110         
Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe
        115                 120                 125             
Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp
    130                 135                 140                 
Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr
145                 150                 155                 160 
Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln
                165                 170                 175     
Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr
            180                 185                 190         
Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu
        195                 200                 205             
Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val
    210                 215                 220                 
Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn
225                 230                 235                 240 
Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys
                245                 250                 255     
Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val
            260                 265                 270         
Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr
        275                 280                 285             
Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys
    290                 295                 300                 
Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr
305                 310                 315                 320 
Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val
                325                 330                 335     
Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn
            340                 345                 350         
Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu
        355                 360                 365             
Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala
    370                 375                 380                 
Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp
385                 390                 395                 400 
Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser
                405                 410                 415     
Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr
            420                 425                 430         
Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met
        435                 440                 445             
Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile
    450                 455                 460                 
Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp
465                 470                 475                 480 
Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr
                485                 490                 495     
Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg
            500                 505                 510         
Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala
        515                 520                 525             
Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val
    530                 535                 540                 
Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg
545                 550                 555                 560 
Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp
                565                 570                 575     
Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly
            580                 585                 590         
Leu Val Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val
        595                 600                 605             
Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val
    610                 615                 620                 
Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala
625                 630                 635                 640 
Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn
                645                 650                 655     
Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile
            660                 665                 670         
Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys
        675                 680                 685             
Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu
    690                 695                 700                 
Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr
705                 710                 715                 720 
Val Ile Leu Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln
                725                 730                 735     
Ala Asp Thr Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser
            740                 745                 750         
Lys Tyr Ser Asp Ile Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr
        755                 760                 765             
Lys Lys Lys Ser Met Leu Asp Ser Glu Val Lys Asn Leu Leu Ser Asp
    770                 775                 780                 
Asp Asn Ser Glu Gly Leu Thr Leu Leu Asp Leu Leu Ser Phe Thr Tyr
785                 790                 795                 800 
Gln Val Ala Arg Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His
                805                 810                 815     
Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Ala Gln Gly Lys Ile Val
            820                 825                 830         
Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Met His Asp Ser Asn
        835                 840                 845             
Tyr Val Ser Lys Gly Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro
    850                 855                 860                 
Glu Ser Ile Phe Asp Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser
865                 870                 875                 880 
Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr
                885                 890                 895     
Pro Gly Met Met Val Asp Ser Thr Phe Tyr Asn Lys Ile Lys Ser Gly
            900                 905                 910         
Tyr Arg Met Ala Lys Pro Asp His Ala Thr Ser Glu Val Tyr Glu Ile
        915                 920                 925             
Met Val Lys Cys Trp Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Tyr
    930                 935                 940                 
His Leu Ser Glu Ile Val Glu Asn Leu Leu Pro Gly Gln Tyr Lys Lys
945                 950                 955                 960 
Ser Tyr Glu Lys Ile His Leu Asp Phe Leu Lys Ser Asp His Pro Ala
                965                 970                 975     
Val Ala Arg Met Arg Val Asp Ser Asp Asn Ala Tyr Ile Gly Val Thr
            980                 985                 990         
Tyr Lys Asn Glu Glu Asp Lys Leu Lys Asp Trp Glu Gly Gly Leu Asp
        995                 1000                1005            
Glu Gln Arg Leu Ser Ala Asp Ser Gly Tyr Ile Ile Pro Leu Pro Asp
    1010                1015                1020                
Ile Asp Pro Val Pro Glu Glu Glu Asp Leu Gly Lys Arg Asn Arg His
1025                1030                1035                1040
Ser Ser Gln Thr Ser Glu Glu Ser Ala Ile Glu Thr Gly Ser Ser Ser
                1045                1050                1055    
Ser Thr Phe Ile Lys Arg Glu Asp Glu Thr Ile Glu Asp Ile Asp Met
            1060                1065                1070        
Met Asp Asp Ile Gly Ile Asp Ser Ser Asp Leu Val Glu Asp Ser Phe
        1075                1080                1085            
Leu
    

<210> 420
<211> 1106
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP002600
<309> 2004-10-26  

<400> 420
Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu
 1               5                  10                  15      
Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly
            20                  25                  30          
Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser
        35                  40                  45              
Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg
    50                  55                  60                  
Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr
65                  70                  75                  80  
Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly
                85                  90                  95      
Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu
            100                 105                 110         
Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu
        115                 120                 125             
Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu
    130                 135                 140                 
Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu
145                 150                 155                 160 
His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln
                165                 170                 175     
Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr
            180                 185                 190         
Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg
        195                 200                 205             
Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val
    210                 215                 220                 
Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn
225                 230                 235                 240 
Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg
                245                 250                 255     
Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile
            260                 265                 270         
Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr
        275                 280                 285             
Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys
    290                 295                 300                 
Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly
305                 310                 315                 320 
Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu
                325                 330                 335     
Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys
            340                 345                 350         
Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser
        355                 360                 365             
Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val
    370                 375                 380                 
Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His
385                 390                 395                 400 
Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro
                405                 410                 415     
Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln
            420                 425                 430         
Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp
        435                 440                 445             
Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr
    450                 455                 460                 
Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val
465                 470                 475                 480 
Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg
                485                 490                 495     
Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn
            500                 505                 510         
Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu
        515                 520                 525             
Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu
    530                 535                 540                 
Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro
545                 550                 555                 560 
Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly
                565                 570                 575     
His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr
            580                 585                 590         
Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser
        595                 600                 605             
Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His
    610                 615                 620                 
Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala
625                 630                 635                 640 
Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser
                645                 650                 655     
His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr
            660                 665                 670         
Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp
        675                 680                 685             
Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His
    690                 695                 700                 
Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu
705                 710                 715                 720 
Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser
                725                 730                 735     
Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val
            740                 745                 750         
Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser
        755                 760                 765             
Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu
    770                 775                 780                 
Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr
785                 790                 795                 800 
Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe
                805                 810                 815     
Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val
            820                 825                 830         
Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala
        835                 840                 845             
Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe
    850                 855                 860                 
Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr
865                 870                 875                 880 
Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile
                885                 890                 895     
Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln
            900                 905                 910         
Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His
        915                 920                 925             
Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys
    930                 935                 940                 
Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg
945                 950                 955                 960 
Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu
                965                 970                 975     
Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu
            980                 985                 990         
Pro Gly Phe His Gly Leu Arg Ser Pro Leu Asp Thr Ser Ser Val Leu
        995                 1000                1005            
Tyr Thr Ala Val Gln Pro Asn Glu Gly Asp Asn Asp Tyr Ile Ile Pro
    1010                1015                1020                
Leu Pro Asp Pro Lys Pro Glu Val Ala Asp Glu Gly Pro Leu Glu Gly
1025                1030                1035                1040
Ser Pro Ser Leu Ala Ser Ser Thr Leu Asn Glu Val Asn Thr Ser Ser
                1045                1050                1055    
Thr Ile Ser Cys Asp Ser Pro Leu Glu Pro Gln Asp Glu Pro Glu Pro
            1060                1065                1070        
Glu Pro Gln Leu Glu Leu Gln Val Glu Pro Glu Pro Glu Leu Glu Gln
        1075                1080                1085            
Leu Pro Asp Ser Gly Cys Pro Ala Pro Arg Ala Glu Ala Glu Asp Ser
    1090                1095                1100                
Phe Leu
1105    

<210> 421
<211> 404
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP001127
<309> 2005-10-31

<400> 421
Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu
 1               5                  10                  15      
Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu
            20                  25                  30          
Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg
        35                  40                  45              
Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu
    50                  55                  60                  
Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro
65                  70                  75                  80  
Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile
                85                  90                  95      
Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn
            100                 105                 110         
Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp
        115                 120                 125             
Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys
    130                 135                 140                 
Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp
145                 150                 155                 160 
Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln
                165                 170                 175     
Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu
            180                 185                 190         
Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys
        195                 200                 205             
Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro
    210                 215                 220                 
Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu
225                 230                 235                 240 
Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr
                245                 250                 255     
Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met
            260                 265                 270         
Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu
        275                 280                 285             
Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr
    290                 295                 300                 
His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile
305                 310                 315                 320 
Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser
                325                 330                 335     
Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly
            340                 345                 350         
Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg
        355                 360                 365             
Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu
    370                 375                 380                 
Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser
385                 390                 395                 400 
Thr Gly Gly Pro
                

<210> 422
<211> 1124
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP000450
<309> 2004-10-26  

<400> 422
Met Asp Ser Leu Ala Ser Leu Val Leu Cys Gly Val Ser Leu Leu Leu
 1               5                  10                  15      
Ser Gly Thr Val Glu Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu
            20                  25                  30          
Pro Leu Val Ser Asp Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly
        35                  40                  45              
Trp Arg Pro His Glu Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu
    50                  55                  60                  
Met Asn Gln His Gln Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg
65                  70                  75                  80  
Glu Trp Ala Lys Lys Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile
                85                  90                  95      
Asn Gly Ala Tyr Phe Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg
            100                 105                 110         
Ile Arg Thr Met Lys Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr
        115                 120                 125             
Leu Thr Met Thr Val Asp Lys Gly Asp Asn Val Asn Ile Ser Phe Lys
    130                 135                 140                 
Lys Val Leu Ile Lys Glu Glu Asp Ala Val Ile Tyr Lys Asn Gly Ser
145                 150                 155                 160 
Phe Ile His Ser Val Pro Arg His Glu Val Pro Asp Ile Leu Glu Val
                165                 170                 175     
His Leu Pro His Ala Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg
            180                 185                 190         
Tyr Ile Gly Gly Asn Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val
        195                 200                 205             
Arg Arg Cys Glu Ala Gln Lys Trp Gly Pro Glu Cys Asn His Leu Cys
    210                 215                 220                 
Thr Ala Cys Met Asn Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys
225                 230                 235                 240 
Ile Cys Pro Pro Gly Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu
                245                 250                 255     
Leu His Thr Phe Gly Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Glu
            260                 265                 270         
Gly Cys Lys Ser Tyr Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser
        275                 280                 285             
Cys Ala Thr Gly Trp Lys Gly Leu Gln Cys Asn Glu Ala Cys His Pro
    290                 295                 300                 
Gly Phe Tyr Gly Pro Asp Cys Lys Leu Arg Cys Ser Cys Asn Asn Gly
305                 310                 315                 320 
Glu Met Cys Asp Arg Phe Gln Gly Cys Leu Cys Ser Pro Gly Trp Gln
                325                 330                 335     
Gly Leu Gln Cys Glu Arg Glu Gly Ile Pro Arg Met Thr Pro Lys Ile
            340                 345                 350         
Val Asp Leu Pro Asp His Ile Glu Val Asn Ser Gly Lys Phe Asn Pro
        355                 360                 365             
Ile Cys Lys Ala Ser Gly Trp Pro Leu Pro Thr Asn Glu Glu Met Thr
    370                 375                 380                 
Leu Val Lys Pro Asp Gly Thr Val Leu His Pro Lys Asp Phe Asn His
385                 390                 395                 400 
Thr Asp His Phe Ser Val Ala Ile Phe Thr Ile His Arg Ile Leu Pro
                405                 410                 415     
Pro Asp Ser Gly Val Trp Val Cys Ser Val Asn Thr Val Ala Gly Met
            420                 425                 430         
Val Glu Lys Pro Phe Asn Ile Ser Val Lys Val Leu Pro Lys Pro Leu
        435                 440                 445             
Asn Ala Pro Asn Val Ile Asp Thr Gly His Asn Phe Ala Val Ile Asn
    450                 455                 460                 
Ile Ser Ser Glu Pro Tyr Phe Gly Asp Gly Pro Ile Lys Ser Lys Lys
465                 470                 475                 480 
Leu Leu Tyr Lys Pro Val Asn His Tyr Glu Ala Trp Gln His Ile Gln
                485                 490                 495     
Val Thr Asn Glu Ile Val Thr Leu Asn Tyr Leu Glu Pro Arg Thr Glu
            500                 505                 510         
Tyr Glu Leu Cys Val Gln Leu Val Arg Arg Gly Glu Gly Gly Glu Gly
        515                 520                 525             
His Pro Gly Pro Val Arg Arg Phe Thr Thr Ala Ser Ile Gly Leu Pro
    530                 535                 540                 
Pro Pro Arg Gly Leu Asn Leu Leu Pro Lys Ser Gln Thr Thr Leu Asn
545                 550                 555                 560 
Leu Thr Trp Gln Pro Ile Phe Pro Ser Ser Glu Asp Asp Phe Tyr Val
                565                 570                 575     
Glu Val Glu Arg Arg Ser Val Gln Lys Ser Asp Gln Gln Asn Ile Lys
            580                 585                 590         
Val Pro Gly Asn Leu Thr Ser Val Leu Leu Asn Asn Leu His Pro Arg
        595                 600                 605             
Glu Gln Tyr Val Val Arg Ala Arg Val Asn Thr Lys Ala Gln Gly Glu
    610                 615                 620                 
Trp Ser Glu Asp Leu Thr Ala Trp Thr Leu Ser Asp Ile Leu Pro Pro
625                 630                 635                 640 
Gln Pro Glu Asn Ile Lys Ile Ser Asn Ile Thr His Ser Ser Ala Val
                645                 650                 655     
Ile Ser Trp Thr Ile Leu Asp Gly Tyr Ser Ile Ser Ser Ile Thr Ile
            660                 665                 670         
Arg Tyr Lys Val Gln Gly Lys Asn Glu Asp Gln His Val Asp Val Lys
        675                 680                 685             
Ile Lys Asn Ala Thr Ile Ile Gln Tyr Gln Leu Lys Gly Leu Glu Pro
    690                 695                 700                 
Glu Thr Ala Tyr Gln Val Asp Ile Phe Ala Glu Asn Asn Ile Gly Ser
705                 710                 715                 720 
Ser Asn Pro Ala Phe Ser His Glu Leu Val Thr Leu Pro Glu Ser Gln
                725                 730                 735     
Ala Pro Ala Asp Leu Gly Gly Gly Lys Met Leu Leu Ile Ala Ile Leu
            740                 745                 750         
Gly Ser Ala Gly Met Thr Cys Leu Thr Val Leu Leu Ala Phe Leu Ile
        755                 760                 765             
Ile Leu Gln Leu Lys Arg Ala Asn Val Gln Arg Arg Met Ala Gln Ala
    770                 775                 780                 
Phe Gln Asn Val Arg Glu Glu Pro Ala Val Gln Phe Asn Ser Gly Thr
785                 790                 795                 800 
Leu Ala Leu Asn Arg Lys Val Lys Asn Asn Pro Asp Pro Thr Ile Tyr
                805                 810                 815     
Pro Val Leu Asp Trp Asn Asp Ile Lys Phe Gln Asp Val Ile Gly Glu
            820                 825                 830         
Gly Asn Phe Gly Gln Val Leu Lys Ala Arg Ile Lys Lys Asp Gly Leu
        835                 840                 845             
Arg Met Asp Ala Ala Ile Lys Arg Met Lys Glu Tyr Ala Ser Lys Asp
    850                 855                 860                 
Asp His Arg Asp Phe Ala Gly Glu Leu Glu Val Leu Cys Lys Leu Gly
865                 870                 875                 880 
His His Pro Asn Ile Ile Asn Leu Leu Gly Ala Cys Glu His Arg Gly
                885                 890                 895     
Tyr Leu Tyr Leu Ala Ile Glu Tyr Ala Pro His Gly Asn Leu Leu Asp
            900                 905                 910         
Phe Leu Arg Lys Ser Arg Val Leu Glu Thr Asp Pro Ala Phe Ala Ile
        915                 920                 925             
Ala Asn Ser Thr Ala Ser Thr Leu Ser Ser Gln Gln Leu Leu His Phe
    930                 935                 940                 
Ala Ala Asp Val Ala Arg Gly Met Asp Tyr Leu Ser Gln Lys Gln Phe
945                 950                 955                 960 
Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Gly Glu Asn Tyr
                965                 970                 975     
Val Ala Lys Ile Ala Asp Phe Gly Leu Ser Arg Gly Gln Glu Val Tyr
            980                 985                 990         
Val Lys Lys Thr Met Gly Arg Leu Pro Val Arg Trp Met Ala Ile Glu
        995                 1000                1005            
Ser Leu Asn Tyr Ser Val Tyr Thr Thr Asn Ser Asp Val Trp Ser Tyr
    1010                1015                1020                
Gly Val Leu Leu Trp Glu Ile Val Ser Leu Gly Gly Thr Pro Tyr Cys
1025                1030                1035                1040
Gly Met Thr Cys Ala Glu Leu Tyr Glu Lys Leu Pro Gln Gly Tyr Arg
                1045                1050                1055    
Leu Glu Lys Pro Leu Asn Cys Asp Asp Glu Val Tyr Asp Leu Met Arg
            1060                1065                1070        
Gln Cys Trp Arg Glu Lys Pro Tyr Glu Arg Pro Ser Phe Ala Gln Ile
        1075                1080                1085            
Leu Val Ser Leu Asn Arg Met Leu Glu Glu Arg Lys Thr Tyr Val Asn
    1090                1095                1100                
Thr Thr Leu Tyr Glu Lys Phe Thr Tyr Ala Gly Ile Asp Cys Ser Ala
1105                1110                1115                1120
Glu Glu Ala Ala
                


<210> 423
<211> 1138
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP005415
<309> 2004-12-18  

<400> 423
Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala
 1               5                  10                  15      
Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg
            20                  25                  30          
Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala
        35                  40                  45              
Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu
    50                  55                  60                  
Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu
65                  70                  75                  80  
Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro
                85                  90                  95      
Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg
            100                 105                 110         
Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu
        115                 120                 125             
Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Ala Val Leu
    130                 135                 140                 
Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser
145                 150                 155                 160 
Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly
                165                 170                 175     
Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile
            180                 185                 190         
Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly Ser Ala Phe Phe
        195                 200                 205             
Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp Gly Pro Gly Cys
    210                 215                 220                 
Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val Cys His Asp His
225                 230                 235                 240 
Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly Thr Arg Cys Glu
                245                 250                 255     
Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys Gln Glu Gln Cys
            260                 265                 270         
Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys Leu Pro Asp Pro
        275                 280                 285             
Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser Gln Cys Gln Glu
    290                 295                 300                 
Ala Cys Ala Pro Gly His Phe Gly Ala Asp Cys Arg Leu Gln Cys Gln
305                 310                 315                 320 
Cys Gln Asn Gly Gly Thr Cys Asp Arg Phe Ser Gly Cys Val Cys Pro
                325                 330                 335     
Ser Gly Trp His Gly Val His Cys Glu Lys Ser Asp Arg Ile Pro Gln
            340                 345                 350         
Ile Leu Asn Met Ala Ser Glu Leu Glu Phe Asn Leu Glu Thr Met Pro
        355                 360                 365             
Arg Ile Asn Cys Ala Ala Ala Gly Asn Pro Phe Pro Val Arg Gly Ser
    370                 375                 380                 
Ile Glu Leu Arg Lys Pro Asp Gly Thr Val Leu Leu Ser Thr Lys Ala
385                 390                 395                 400 
Ile Val Glu Pro Glu Lys Thr Thr Ala Glu Phe Glu Val Pro Arg Leu
                405                 410                 415     
Val Leu Ala Asp Ser Gly Phe Trp Glu Cys Arg Val Ser Thr Ser Gly
            420                 425                 430         
Gly Gln Asp Ser Arg Arg Phe Lys Val Asn Val Lys Val Pro Pro Val
        435                 440                 445             
Pro Leu Ala Ala Pro Arg Leu Leu Thr Lys Gln Ser Arg Gln Leu Val
    450                 455                 460                 
Val Ser Pro Leu Val Ser Phe Ser Gly Asp Gly Pro Ile Ser Thr Val
465                 470                 475                 480 
Arg Leu His Tyr Arg Pro Gln Asp Ser Thr Met Asp Trp Ser Thr Ile
                485                 490                 495     
Val Val Asp Pro Ser Glu Asn Val Thr Leu Met Asn Leu Arg Pro Lys
            500                 505                 510         
Thr Gly Tyr Ser Val Arg Val Gln Leu Ser Arg Pro Gly Glu Gly Gly
        515                 520                 525             
Glu Gly Ala Trp Gly Pro Pro Thr Leu Met Thr Thr Asp Cys Pro Glu
    530                 535                 540                 
Pro Leu Leu Gln Pro Trp Leu Glu Gly Trp His Val Glu Gly Thr Asp
545                 550                 555                 560 
Arg Leu Arg Val Ser Trp Ser Leu Pro Leu Val Pro Gly Pro Leu Val
                565                 570                 575     
Gly Asp Gly Phe Leu Leu Arg Leu Trp Asp Gly Thr Arg Gly Gln Glu
            580                 585                 590         
Arg Arg Glu Asn Val Ser Ser Pro Gln Ala Arg Thr Ala Leu Leu Thr
        595                 600                 605             
Gly Leu Thr Pro Gly Thr His Tyr Gln Leu Asp Val Gln Leu Tyr His
    610                 615                 620                 
Cys Thr Leu Leu Gly Pro Ala Ser Pro Pro Ala His Val Leu Leu Pro
625                 630                 635                 640 
Pro Ser Gly Pro Pro Ala Pro Arg His Leu His Ala Gln Ala Leu Ser
                645                 650                 655     
Asp Ser Glu Ile Gln Leu Thr Trp Lys His Pro Glu Ala Leu Pro Gly
            660                 665                 670         
Pro Ile Ser Lys Tyr Val Val Glu Val Gln Val Ala Gly Gly Ala Gly
        675                 680                 685             
Asp Pro Leu Trp Ile Asp Val Asp Arg Pro Glu Glu Thr Ser Thr Ile
    690                 695                 700                 
Ile Arg Gly Leu Asn Ala Ser Thr Arg Tyr Leu Phe Arg Met Arg Ala
705                 710                 715                 720 
Ser Ile Gln Gly Leu Gly Asp Trp Ser Asn Thr Val Glu Glu Ser Thr
                725                 730                 735     
Leu Gly Asn Gly Leu Gln Ala Glu Gly Pro Val Gln Glu Ser Arg Ala
            740                 745                 750         
Ala Glu Glu Gly Leu Asp Gln Gln Leu Ile Leu Ala Val Val Gly Ser
        755                 760                 765             
Val Ser Ala Thr Cys Leu Thr Ile Leu Ala Ala Leu Leu Thr Leu Val
    770                 775                 780                 
Cys Ile Arg Arg Ser Cys Leu His Arg Arg Arg Thr Phe Thr Tyr Gln
785                 790                 795                 800 
Ser Gly Ser Gly Glu Glu Thr Ile Leu Gln Phe Ser Ser Gly Thr Leu
                805                 810                 815     
Thr Leu Thr Arg Arg Pro Lys Leu Gln Pro Glu Pro Leu Ser Tyr Pro
            820                 825                 830         
Val Leu Glu Trp Glu Asp Ile Thr Phe Glu Asp Leu Ile Gly Glu Gly
        835                 840                 845             
Asn Phe Gly Gln Val Ile Arg Ala Met Ile Lys Lys Asp Gly Leu Lys
    850                 855                 860                 
Met Asn Ala Ala Ile Lys Met Leu Lys Glu Tyr Ala Ser Glu Asn Asp
865                 870                 875                 880 
His Arg Asp Phe Ala Gly Glu Leu Glu Val Leu Cys Lys Leu Gly His
                885                 890                 895     
His Pro Asn Ile Ile Asn Leu Leu Gly Ala Cys Lys Asn Arg Gly Tyr
            900                 905                 910         
Leu Tyr Ile Ala Ile Glu Tyr Ala Pro Tyr Gly Asn Leu Leu Asp Phe
        915                 920                 925             
Leu Arg Lys Ser Arg Val Leu Glu Thr Asp Pro Ala Phe Ala Arg Glu
    930                 935                 940                 
His Gly Thr Ala Ser Thr Leu Ser Ser Arg Gln Leu Leu Arg Phe Ala
945                 950                 955                 960 
Ser Asp Ala Ala Asn Gly Met Gln Tyr Leu Ser Glu Lys Gln Phe Ile
                965                 970                 975     
His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Gly Glu Asn Leu Ala
            980                 985                 990         
Ser Lys Ile Ala Asp Phe Gly Leu Ser Arg Gly Glu Glu Val Tyr Val
        995                 1000                1005            
Lys Lys Thr Met Gly Arg Leu Pro Val Arg Trp Met Ala Ile Glu Ser
    1010                1015                1020                
Leu Asn Tyr Ser Val Tyr Thr Thr Lys Ser Asp Val Trp Ser Phe Gly
1025                1030                1035                1040
Val Leu Leu Trp Glu Ile Val Ser Leu Gly Gly Thr Pro Tyr Cys Gly
                1045                1050                1055    
Met Thr Cys Ala Glu Leu Tyr Glu Lys Leu Pro Gln Gly Tyr Arg Met
            1060                1065                1070        
Glu Gln Pro Arg Asn Cys Asp Asp Glu Val Tyr Glu Leu Met Arg Gln
        1075                1080                1085            
Cys Trp Arg Asp Arg Pro Tyr Glu Arg Pro Pro Phe Ala Gln Ile Ala
    1090                1095                1100                
Leu Gln Leu Gly Arg Met Leu Glu Ala Arg Lys Ala Tyr Val Asn Met
1105                1110                1115                1120
Ser Leu Phe Glu Asn Phe Thr Tyr Ala Gly Ile Asp Ala Thr Ala Glu
                1125                1130                1135    
Glu Ala
        


<210> 424
<211> 455
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP001056
<309> 2004-10-27  

<400> 424
Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu
 1               5                  10                  15      
Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro
            20                  25                  30          
His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys
        35                  40                  45              
Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys
    50                  55                  60                  
Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp
65                  70                  75                  80  
Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu
                85                  90                  95      
Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val
            100                 105                 110         
Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg
        115                 120                 125             
Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe
    130                 135                 140                 
Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu
145                 150                 155                 160 
Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu
                165                 170                 175     
Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr
            180                 185                 190         
Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser
        195                 200                 205             
Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu
    210                 215                 220                 
Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys
225                 230                 235                 240 
Ser Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu
                245                 250                 255     
Gly Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser
            260                 265                 270         
Phe Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val
        275                 280                 285             
Pro Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys
    290                 295                 300                 
Pro Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly
305                 310                 315                 320 
Ala Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn
                325                 330                 335     
Pro Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp
            340                 345                 350         
Thr Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro
        355                 360                 365             
Leu Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu
    370                 375                 380                 
Ile Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln
385                 390                 395                 400 
Tyr Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Pro Arg Arg Glu Ala
                405                 410                 415     
Thr Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly
            420                 425                 430         
Cys Leu Glu Asp Ile Glu Glu Ala Leu Cys Gly Pro Ala Ala Leu Pro
        435                 440                 445             
Pro Ala Pro Ser Leu Leu Arg
    450                 455 


<210> 425
<211> 461
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP001057
<309> 2004-10-26  

<400> 425
Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu
 1               5                  10                  15      
Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr
            20                  25                  30          
Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln
        35                  40                  45              
Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys
    50                  55                  60                  
Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp
65                  70                  75                  80  
Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys
                85                  90                  95      
Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg
            100                 105                 110         
Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu
        115                 120                 125             
Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg
    130                 135                 140                 
Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val
145                 150                 155                 160 
Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr
                165                 170                 175     
Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly
            180                 185                 190         
Asn Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser
        195                 200                 205             
Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser
    210                 215                 220                 
Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser
225                 230                 235                 240 
Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly
                245                 250                 255     
Asp Phe Ala Leu Pro Val Gly Leu Ile Val Gly Val Thr Ala Leu Gly
            260                 265                 270         
Leu Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val Lys
        275                 280                 285             
Lys Lys Pro Leu Cys Leu Gln Arg Glu Ala Lys Val Pro His Leu Pro
    290                 295                 300                 
Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His Leu Leu
305                 310                 315                 320 
Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser
                325                 330                 335     
Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly
            340                 345                 350         
Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser
        355                 360                 365             
Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile
    370                 375                 380                 
Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser Gln
385                 390                 395                 400 
Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu Ser Pro
                405                 410                 415     
Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser
            420                 425                 430         
Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro
        435                 440                 445             
Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser
    450                 455                 460     


<210> 426
<211> 1338
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP002010
<309> 2004-10-28  

<400> 426
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser
 1               5                  10                  15      
Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro
            20                  25                  30          
Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr
        35                  40                  45              
Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro
    50                  55                  60                  
Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala
65                  70                  75                  80  
Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr
                85                  90                  95      
Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val
            100                 105                 110         
Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile
        115                 120                 125             
Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu
    130                 135                 140                 
Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val
145                 150                 155                 160 
Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr
                165                 170                 175     
Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe
            180                 185                 190         
Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu
        195                 200                 205             
Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg
    210                 215                 220                 
Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val
225                 230                 235                 240 
Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr
                245                 250                 255     
Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys
            260                 265                 270         
Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His
        275                 280                 285             
Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys
    290                 295                 300                 
Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys
305                 310                 315                 320 
Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val
                325                 330                 335     
Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser
            340                 345                 350         
Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val
        355                 360                 365             
Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu
    370                 375                 380                 
Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala
385                 390                 395                 400 
Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys
                405                 410                 415     
Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu
            420                 425                 430         
Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser
        435                 440                 445             
Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile
    450                 455                 460                 
Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys
465                 470                 475                 480 
Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser
                485                 490                 495     
Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile
            500                 505                 510         
Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg
        515                 520                 525             
Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val
    530                 535                 540                 
Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His
545                 550                 555                 560 
Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser
                565                 570                 575     
Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu
            580                 585                 590         
Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys
        595                 600                 605             
Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met
    610                 615                 620                 
Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn
625                 630                 635                 640 
Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg
                645                 650                 655     
Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn Leu Ser Asp His Thr Val
            660                 665                 670         
Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys His Ala Asn Gly Val Pro
        675                 680                 685             
Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn His Lys Ile Gln Gln Glu
    690                 695                 700                 
Pro Gly Ile Ile Leu Gly Pro Gly Ser Ser Thr Leu Phe Ile Glu Arg
705                 710                 715                 720 
Val Thr Glu Glu Asp Glu Gly Val Tyr His Cys Lys Ala Thr Asn Gln
                725                 730                 735     
Lys Gly Ser Val Glu Ser Ser Ala Tyr Leu Thr Val Gln Gly Thr Ser
            740                 745                 750         
Asp Lys Ser Asn Leu Glu Leu Ile Thr Leu Thr Cys Thr Cys Val Ala
        755                 760                 765             
Ala Thr Leu Phe Trp Leu Leu Leu Thr Leu Leu Ile Arg Lys Met Lys
    770                 775                 780                 
Arg Ser Ser Ser Glu Ile Lys Thr Asp Tyr Leu Ser Ile Ile Met Asp
785                 790                 795                 800 
Pro Asp Glu Val Pro Leu Asp Glu Gln Cys Glu Arg Leu Pro Tyr Asp
                805                 810                 815     
Ala Ser Lys Trp Glu Phe Ala Arg Glu Arg Leu Lys Leu Gly Lys Ser
            820                 825                 830         
Leu Gly Arg Gly Ala Phe Gly Lys Val Val Gln Ala Ser Ala Phe Gly
        835                 840                 845             
Ile Lys Lys Ser Pro Thr Cys Arg Thr Val Ala Val Lys Met Leu Lys
    850                 855                 860                 
Glu Gly Ala Thr Ala Ser Glu Tyr Lys Ala Leu Met Thr Glu Leu Lys
865                 870                 875                 880 
Ile Leu Thr His Ile Gly His His Leu Asn Val Val Asn Leu Leu Gly
                885                 890                 895     
Ala Cys Thr Lys Gln Gly Gly Pro Leu Met Val Ile Val Glu Tyr Cys
            900                 905                 910         
Lys Tyr Gly Asn Leu Ser Asn Tyr Leu Lys Ser Lys Arg Asp Leu Phe
        915                 920                 925             
Phe Leu Asn Lys Asp Ala Ala Leu His Met Glu Pro Lys Lys Glu Lys
    930                 935                 940                 
Met Glu Pro Gly Leu Glu Gln Gly Lys Lys Pro Arg Leu Asp Ser Val
945                 950                 955                 960 
Thr Ser Ser Glu Ser Phe Ala Ser Ser Gly Phe Gln Glu Asp Lys Ser
                965                 970                 975     
Leu Ser Asp Val Glu Glu Glu Glu Asp Ser Asp Gly Phe Tyr Lys Glu
            980                 985                 990         
Pro Ile Thr Met Glu Asp Leu Ile Ser Tyr Ser Phe Gln Val Ala Arg
        995                 1000                1005            
Gly Met Glu Phe Leu Ser Ser Arg Lys Cys Ile His Arg Asp Leu Ala
    1010                1015                1020                
Ala Arg Asn Ile Leu Leu Ser Glu Asn Asn Val Val Lys Ile Cys Asp
1025                1030                1035                1040
Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asn Pro Asp Tyr Val Arg Lys
                1045                1050                1055    
Gly Asp Thr Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe
            1060                1065                1070        
Asp Lys Ile Tyr Ser Thr Lys Ser Asp Val Trp Ser Tyr Gly Val Leu
        1075                1080                1085            
Leu Trp Glu Ile Phe Ser Leu Gly Gly Ser Pro Tyr Pro Gly Val Gln
    1090                1095                1100                
Met Asp Glu Asp Phe Cys Ser Arg Leu Arg Glu Gly Met Arg Met Arg
1105                1110                1115                1120
Ala Pro Glu Tyr Ser Thr Pro Glu Ile Tyr Gln Ile Met Leu Asp Cys
                1125                1130                1135    
Trp His Arg Asp Pro Lys Glu Arg Pro Arg Phe Ala Glu Leu Val Glu
            1140                1145                1150        
Lys Leu Gly Asp Leu Leu Gln Ala Asn Val Gln Gln Asp Gly Lys Asp
        1155                1160                1165            
Tyr Ile Pro Ile Asn Ala Ile Leu Thr Gly Asn Ser Gly Phe Thr Tyr
    1170                1175                1180                
Ser Thr Pro Ala Phe Ser Glu Asp Phe Phe Lys Glu Ser Ile Ser Ala
1185                1190                1195                1200
Pro Lys Phe Asn Ser Gly Ser Ser Asp Asp Val Arg Tyr Val Asn Ala
                1205                1210                1215    
Phe Lys Phe Met Ser Leu Glu Arg Ile Lys Thr Phe Glu Glu Leu Leu
            1220                1225                1230        
Pro Asn Ala Thr Ser Met Phe Asp Asp Tyr Gln Gly Asp Ser Ser Thr
        1235                1240                1245            
Leu Leu Ala Ser Pro Met Leu Lys Arg Phe Thr Trp Thr Asp Ser Lys
    1250                1255                1260                
Pro Lys Ala Ser Leu Lys Ile Asp Leu Arg Val Thr Ser Lys Ser Lys
1265                1270                1275                1280
Glu Ser Gly Leu Ser Asp Val Ser Arg Pro Ser Phe Cys His Ser Ser
                1285                1290                1295    
Cys Gly His Val Ser Glu Gly Lys Arg Arg Phe Thr Tyr Asp His Ala
            1300                1305                1310        
Glu Leu Glu Arg Lys Ile Ala Cys Cys Ser Pro Pro Pro Asp Tyr Asn
        1315                1320                1325            
Ser Val Val Leu Tyr Ser Thr Pro Pro Ile
    1330                1335            


<210> 427
<211> 1356
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP002244
<309> 2004-10-26  

<400> 427
Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu
 1               5                  10                  15      
Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro
            20                  25                  30          
Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr
        35                  40                  45              
Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro
    50                  55                  60                  
Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser
65                  70                  75                  80  
Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn
                85                  90                  95      
Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser
            100                 105                 110         
Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser
        115                 120                 125             
Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys
    130                 135                 140                 
Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser
145                 150                 155                 160 
Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg
                165                 170                 175     
Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile
            180                 185                 190         
Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser
        195                 200                 205             
Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr
    210                 215                 220                 
Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu
225                 230                 235                 240 
Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile
                245                 250                 255     
Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu
            260                 265                 270         
Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe
        275                 280                 285             
Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu
    290                 295                 300                 
Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr
305                 310                 315                 320 
Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met
                325                 330                 335     
Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala
            340                 345                 350         
Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly
        355                 360                 365             
Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr
    370                 375                 380                 
Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu
385                 390                 395                 400 
Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val
                405                 410                 415     
Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val
            420                 425                 430         
Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr
        435                 440                 445             
Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu
    450                 455                 460                 
Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr
465                 470                 475                 480 
Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys
                485                 490                 495     
Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys
            500                 505                 510         
Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr
        515                 520                 525             
Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser
    530                 535                 540                 
Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln
545                 550                 555                 560 
Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser
                565                 570                 575     
Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro
            580                 585                 590         
Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr
        595                 600                 605             
Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile
    610                 615                 620                 
Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr
625                 630                 635                 640 
Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val
                645                 650                 655     
Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn
            660                 665                 670         
Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys
        675                 680                 685             
Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn
    690                 695                 700                 
Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg
705                 710                 715                 720 
Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr
                725                 730                 735     
Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe
            740                 745                 750         
Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu
        755                 760                 765             
Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile
    770                 775                 780                 
Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly
785                 790                 795                 800 
Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His
                805                 810                 815     
Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp
            820                 825                 830         
Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val
        835                 840                 845             
Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr
    850                 855                 860                 
Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg
865                 870                 875                 880 
Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu
                885                 890                 895     
Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu
            900                 905                 910         
Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu
        915                 920                 925             
Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg
    930                 935                 940                 
Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys
945                 950                 955                 960 
Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly
                965                 970                 975     
Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro
            980                 985                 990         
Glu Asp Leu Tyr Lys Asp Phe Leu Thr Leu Glu His Leu Ile Cys Tyr
        995                 1000                1005            
Ser Phe Gln Val Ala Lys Gly Met Glu Phe Leu Ala Ser Arg Lys Cys
    1010                1015                1020                
Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Ser Glu Lys Asn
1025                1030                1035                1040
Val Val Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asp
                1045                1050                1055    
Pro Asp Tyr Val Arg Lys Gly Asp Ala Arg Leu Pro Leu Lys Trp Met
            1060                1065                1070        
Ala Pro Glu Thr Ile Phe Asp Arg Val Tyr Thr Ile Gln Ser Asp Val
        1075                1080                1085            
Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Ala Ser
    1090                1095                1100                
Pro Tyr Pro Gly Val Lys Ile Asp Glu Glu Phe Cys Arg Arg Leu Lys
1105                1110                1115                1120
Glu Gly Thr Arg Met Arg Ala Pro Asp Tyr Thr Thr Pro Glu Met Tyr
                1125                1130                1135    
Gln Thr Met Leu Asp Cys Trp His Gly Glu Pro Ser Gln Arg Pro Thr
            1140                1145                1150        
Phe Ser Glu Leu Val Glu His Leu Gly Asn Leu Leu Gln Ala Asn Ala
        1155                1160                1165            
Gln Gln Asp Gly Lys Asp Tyr Ile Val Leu Pro Ile Ser Glu Thr Leu
    1170                1175                1180                
Ser Met Glu Glu Asp Ser Gly Leu Ser Leu Pro Thr Ser Pro Val Ser
1185                1190                1195                1200
Cys Met Glu Glu Glu Glu Val Cys Asp Pro Lys Phe His Tyr Asp Asn
                1205                1210                1215    
Thr Ala Gly Ile Ser Gln Tyr Leu Gln Asn Ser Lys Arg Lys Ser Arg
            1220                1225                1230        
Pro Val Ser Val Lys Thr Phe Glu Asp Ile Pro Leu Glu Glu Pro Glu
        1235                1240                1245            
Val Lys Val Ile Pro Asp Asp Asn Gln Thr Asp Ser Gly Met Val Leu
    1250                1255                1260                
Ala Ser Glu Glu Leu Lys Thr Leu Glu Asp Arg Thr Lys Leu Ser Pro
1265                1270                1275                1280
Ser Phe Gly Gly Met Val Pro Ser Lys Ser Arg Glu Ser Val Ala Ser
                1285                1290                1295    
Glu Gly Ser Asn Gln Thr Ser Gly Tyr Gln Ser Gly Tyr His Ser Asp
            1300                1305                1310        
Asp Thr Asp Thr Thr Val Tyr Ser Ser Glu Glu Ala Glu Leu Leu Lys
        1315                1320                1325            
Leu Ile Glu Ile Gly Val Gln Thr Gly Ser Thr Ala Gln Ile Leu Gln
    1330                1335                1340                
Pro Asp Ser Gly Thr Thr Leu Ser Ser Pro Pro Val
1345                1350                1355    


<210> 428
<211> 1298
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP002011
<309> 2004-12-18  

<400> 428
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15      
Leu Leu Asp Gly Leu Val Ser Asp Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30          
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45              
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60                  
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80  
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95      
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110         
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125             
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140                 
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160 
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175     
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190         
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205             
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220                 
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240 
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255     
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270         
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285             
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300                 
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320 
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335     
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350         
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365             
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380                 
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400 
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415     
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430         
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445             
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460                 
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480 
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495     
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510         
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525             
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540                 
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560 
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575     
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590         
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605             
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620                 
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640 
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655     
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670         
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685             
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700                 
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720 
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735     
Arg Val Arg Glu Glu Asp Ala Gly Pro Tyr Leu Cys Ser Val Cys Arg
            740                 745                 750         
Pro Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765             
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780                 
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800 
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815     
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830         
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845             
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860                 
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880 
Leu Lys Glu Gly Ala Thr Ala Ser Glu Gln Arg Ala Leu Met Ser Glu
                885                 890                 895     
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910         
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925             
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940                 
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960 
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975     
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990         
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005            
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020                
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055    
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070        
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085            
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100                
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Val Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135    
Pro Glu Leu Ala Thr Pro Ala Ile Arg His Ile Met Leu Asn Cys Trp
            1140                1145                1150        
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Asp Leu Val Glu Ile
        1155                1160                1165            
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180                
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215    
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230        
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245            
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260                
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295    
Phe Arg
        

<210> 429
<211> 913
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 53
<223> Xaa = W or A

<220> 
<221> VARIANT        
<222> 55,  68
<223> Xaa = D or A

<220> 
<221> VARIANT        
<222> 66, 175
<223> Xaa = S or A

<220> 
<221> VARIANT        
<222> 105
<223> Xaa = R or A

<220> 
<221> VARIANT        
<222> 106
<223> Xaa = H or A

<220> 
<221> VARIANT        
<222> 110
<223> Xaa = L or A

<220> 
<221> VARIANT        
<222> 112
<223> Xaa = K or A

<220> 
<221> VARIANT        
<222> 173
<223> Xaa = V or A

<220> 
<221> VARIANT        
<222> 174
<223> Xaa = M or A

<400> 429
Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala
 1               5                  10                  15      
Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg
            20                  25                  30          
Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser
        35                  40                  45              
Ala Ser Ser Ser Xaa Ser Xaa Ser Thr Ala Ala Arg His Ser Arg Leu
    50                  55                  60                  
Glu Xaa Ser Xaa Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe
65                  70                  75                  80  
Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu
                85                  90                  95      
Val Ala Leu Val Gly Thr Gln Gly Xaa Xaa Ala Gly Gly Xaa Gly Xaa
            100                 105                 110         
Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg
        115                 120                 125             
Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn
    130                 135                 140                 
Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val
145                 150                 155                 160 
Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Xaa Xaa Xaa Val
                165                 170                 175     
Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu
            180                 185                 190         
Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val
        195                 200                 205             
Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln
    210                 215                 220                 
Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp
225                 230                 235                 240 
Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val
                245                 250                 255     
Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe
            260                 265                 270         
Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn
        275                 280                 285             
Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg
    290                 295                 300                 
Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His
305                 310                 315                 320 
Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val
                325                 330                 335     
Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe
            340                 345                 350         
Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val
        355                 360                 365             
Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro
    370                 375                 380                 
Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu
385                 390                 395                 400 
Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr
                405                 410                 415     
Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu
            420                 425                 430         
Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser
        435                 440                 445             
Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser
    450                 455                 460                 
Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu
465                 470                 475                 480 
Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser
                485                 490                 495     
Ala Pro Cys Val Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala
            500                 505                 510         
Tyr Arg Leu Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly Pro Gly
        515                 520                 525             
Pro Pro Thr Pro Ala Trp Ala Lys Pro Thr Asn Thr Gln Ala Tyr Ser
    530                 535                 540                 
Gly Asp Tyr Met Glu Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro
545                 550                 555                 560 
Pro Pro Gln Asn Ser Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr
                565                 570                 575     
Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro
            580                 585                 590         
Pro Gly Ala Val Gly Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser
        595                 600                 605             
Arg Leu Arg Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val
    610                 615                 620                 
His Leu Cys Glu Val Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe
625                 630                 635                 640 
Pro Leu Asn Val Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile
                645                 650                 655     
Leu Arg Pro Asp Ala Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu
            660                 665                 670         
Val Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu
        675                 680                 685             
Gly Val Cys Val Gln Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met
    690                 695                 700                 
Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp
705                 710                 715                 720 
Lys Ala Ala Glu Gly Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro
                725                 730                 735     
Thr Ile Ser Tyr Pro Met Leu Leu His Val Ala Ala Gln Ile Ala Ser
            740                 745                 750         
Gly Met Arg Tyr Leu Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala
        755                 760                 765             
Thr Arg Asn Cys Leu Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp
    770                 775                 780                 
Phe Gly Met Ser Arg Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln
785                 790                 795                 800 
Gly Arg Ala Val Leu Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu
                805                 810                 815     
Met Gly Lys Phe Thr Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr
            820                 825                 830         
Leu Trp Glu Val Leu Met Leu Cys Arg Ala Gln Pro Phe Gly Ser Ala
        835                 840                 845             
His Arg Arg Ala Gly His Arg Glu Arg Gly Gly Val Leu Pro Gly Pro
    850                 855                 860                 
Gly Pro Ala Val Tyr Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu
865                 870                 875                 880 
Tyr Glu Leu Met Leu Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro
                885                 890                 895     
Pro Phe Ser Gln Leu His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr
            900                 905                 910         
Val
    


<210> 430
<211> 855
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 550
<223> Xaa = G or R

<400> 430
Met Ile Leu Ile Pro Arg Met Leu Leu Val Leu Phe Leu Leu Leu Pro
 1               5                  10                  15      
Ile Leu Ser Ser Ala Lys Ala Gln Val Asn Pro Ala Ile Cys Arg Tyr
            20                  25                  30          
Pro Leu Gly Met Ser Gly Gly Gln Ile Pro Asp Glu Asp Ile Thr Ala
        35                  40                  45              
Ser Ser Gln Trp Ser Glu Ser Thr Ala Ala Lys Tyr Gly Arg Leu Asp
    50                  55                  60                  
Ser Glu Glu Gly Asp Gly Ala Trp Cys Pro Glu Ile Pro Val Glu Pro
65                  70                  75                  80  
Asp Asp Leu Lys Glu Phe Leu Gln Ile Asp Leu His Thr Leu His Phe
                85                  90                  95      
Ile Thr Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly His Gly Ile
            100                 105                 110         
Glu Phe Ala Pro Met Tyr Lys Ile Asn Tyr Ser Arg Asp Gly Thr Arg
        115                 120                 125             
Trp Ile Ser Trp Arg Asn Arg His Gly Lys Gln Val Leu Asp Gly Asn
    130                 135                 140                 
Ser Asn Pro Tyr Asp Ile Phe Leu Lys Asp Leu Glu Pro Pro Ile Val
145                 150                 155                 160 
Ala Arg Phe Val Arg Phe Ile Pro Val Thr Asp His Ser Met Asn Val
                165                 170                 175     
Cys Met Arg Val Glu Leu Tyr Gly Cys Val Trp Leu Asp Gly Leu Val
            180                 185                 190         
Ser Tyr Asn Ala Pro Ala Gly Gln Gln Phe Val Leu Pro Gly Gly Ser
        195                 200                 205             
Ile Ile Tyr Leu Asn Asp Ser Val Tyr Asp Gly Ala Val Gly Tyr Ser
    210                 215                 220                 
Met Thr Glu Gly Leu Gly Gln Leu Thr Asp Gly Val Ser Gly Leu Asp
225                 230                 235                 240 
Asp Phe Thr Gln Thr His Glu Tyr His Val Trp Pro Gly Tyr Asp Tyr
                245                 250                 255     
Val Gly Trp Arg Asn Glu Ser Ala Thr Asn Gly Tyr Ile Glu Ile Met
            260                 265                 270         
Phe Glu Phe Asp Arg Ile Arg Asn Phe Thr Thr Met Lys Val His Cys
        275                 280                 285             
Asn Asn Met Phe Ala Lys Gly Val Lys Ile Phe Lys Glu Val Gln Cys
    290                 295                 300                 
Tyr Phe Arg Ser Glu Ala Ser Glu Trp Glu Pro Asn Ala Ile Ser Phe
305                 310                 315                 320 
Pro Leu Val Leu Asp Asp Val Asn Pro Ser Ala Arg Phe Val Thr Val
                325                 330                 335     
Pro Leu His His Arg Met Ala Ser Ala Ile Lys Cys Gln Tyr His Phe
            340                 345                 350         
Ala Asp Thr Trp Met Met Phe Ser Glu Ile Thr Phe Gln Ser Asp Ala
        355                 360                 365             
Ala Met Tyr Asn Asn Ser Glu Ala Leu Pro Thr Ser Pro Met Ala Pro
    370                 375                 380                 
Thr Thr Tyr Asp Pro Met Leu Lys Val Asp Asp Ser Asn Thr Arg Ile
385                 390                 395                 400 
Leu Ile Gly Cys Leu Val Ala Ile Ile Phe Ile Leu Leu Ala Ile Ile
                405                 410                 415     
Val Ile Ile Leu Trp Arg Gln Phe Trp Gln Lys Met Leu Glu Lys Ala
            420                 425                 430         
Ser Arg Arg Met Leu Asp Asp Glu Met Thr Val Ser Leu Ser Leu Pro
        435                 440                 445             
Ser Asp Ser Ser Met Phe Asn Asn Asn Arg Ser Ser Ser Pro Ser Glu
    450                 455                 460                 
Gln Gly Ser Asn Ser Thr Tyr Asp Arg Ile Phe Pro Leu Arg Pro Asp
465                 470                 475                 480 
Tyr Gln Glu Pro Ser Arg Leu Ile Arg Lys Leu Pro Glu Phe Ala Pro
                485                 490                 495     
Gly Glu Glu Glu Ser Gly Cys Ser Gly Val Val Lys Pro Val Gln Pro
            500                 505                 510         
Ser Gly Pro Glu Gly Val Pro His Tyr Ala Glu Ala Asp Ile Val Asn
        515                 520                 525             
Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ser Val Pro Ala Val Thr
    530                 535                 540                 
Met Asp Leu Leu Ser Xaa Lys Asp Val Ala Val Glu Glu Phe Pro Arg
545                 550                 555                 560 
Lys Leu Leu Thr Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu
                565                 570                 575     
Val His Leu Cys Glu Val Glu Gly Met Glu Lys Phe Lys Asp Lys Asp
            580                 585                 590         
Phe Ala Leu Asp Val Ser Ala Asn Gln Pro Val Leu Val Ala Val Lys
        595                 600                 605             
Met Leu Arg Ala Asp Ala Asn Lys Asn Ala Arg Asn Asp Phe Leu Lys
    610                 615                 620                 
Glu Ile Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile His Leu
625                 630                 635                 640 
Leu Ser Val Cys Ile Thr Asp Asp Pro Leu Cys Met Ile Thr Glu Tyr
                645                 650                 655     
Met Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Arg His Glu Pro Pro
            660                 665                 670         
Asn Ser Ser Ser Ser Asp Val Arg Thr Val Ser Tyr Thr Asn Leu Lys
        675                 680                 685             
Phe Met Ala Thr Gln Ile Ala Ser Gly Met Lys Tyr Leu Ser Ser Leu
    690                 695                 700                 
Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Lys
705                 710                 715                 720 
Asn Tyr Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg Asn Leu Tyr
                725                 730                 735     
Ser Gly Asp Tyr Tyr Arg Ile Gln Gly Arg Ala Val Leu Pro Ile Arg
            740                 745                 750         
Trp Met Ser Trp Glu Ser Ile Leu Leu Gly Lys Phe Thr Thr Ala Ser
        755                 760                 765             
Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Thr Phe Thr Phe Cys
    770                 775                 780                 
Gln Glu Gln Pro Tyr Ser Gln Leu Ser Asp Glu Gln Val Ile Glu Asn
785                 790                 795                 800 
Thr Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Thr Tyr Leu Pro Gln
                805                 810                 815     
Pro Ala Ile Cys Pro Asp Ser Val Tyr Lys Leu Met Leu Ser Cys Trp
            820                 825                 830         
Arg Arg Asp Thr Lys Asn Arg Pro Ser Phe Gln Glu Ile His Leu Leu
        835                 840                 845             
Leu Leu Gln Gln Gly Asp Glu
    850                 855 

<210> 431
<211> 976
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 160
<223> Xaa = A or V

<400> 431
Met Glu Arg Arg Trp Pro Leu Gly Leu Gly Leu Val Leu Leu Leu Cys
 1               5                  10                  15      
Ala Pro Leu Pro Pro Gly Ala Arg Ala Lys Glu Val Thr Leu Met Asp
            20                  25                  30          
Thr Ser Lys Ala Gln Gly Glu Leu Gly Trp Leu Leu Asp Pro Pro Lys
        35                  40                  45              
Asp Gly Trp Ser Glu Gln Gln Gln Ile Leu Asn Gly Thr Pro Leu Tyr
    50                  55                  60                  
Met Tyr Gln Asp Cys Pro Met Gln Gly Arg Arg Asp Thr Asp His Trp
65                  70                  75                  80  
Leu Arg Ser Asn Trp Ile Tyr Arg Gly Glu Glu Ala Ser Arg Val His
                85                  90                  95      
Val Glu Leu Gln Phe Thr Val Arg Asp Cys Lys Ser Phe Pro Gly Gly
            100                 105                 110         
Ala Gly Pro Leu Gly Cys Lys Glu Thr Phe Asn Leu Leu Tyr Met Glu
        115                 120                 125             
Ser Asp Gln Asp Val Gly Ile Gln Leu Arg Arg Pro Leu Phe Gln Lys
    130                 135                 140                 
Val Thr Thr Val Ala Ala Asp Gln Ser Phe Thr Ile Arg Asp Leu Xaa
145                 150                 155                 160 
Ser Gly Ser Val Lys Leu Asn Val Glu Arg Cys Ser Leu Gly Arg Leu
                165                 170                 175     
Thr Arg Arg Gly Leu Tyr Leu Ala Phe His Asn Pro Gly Ala Cys Val
            180                 185                 190         
Ala Leu Val Ser Val Arg Val Phe Tyr Gln Arg Cys Pro Glu Thr Leu
        195                 200                 205             
Asn Gly Leu Ala Gln Phe Pro Asp Thr Leu Pro Gly Pro Ala Gly Leu
    210                 215                 220                 
Val Glu Val Ala Gly Thr Cys Leu Pro His Ala Arg Ala Ser Pro Arg
225                 230                 235                 240 
Pro Ser Gly Ala Pro Arg Met His Cys Ser Pro Asp Gly Glu Trp Leu
                245                 250                 255     
Val Pro Val Gly Arg Cys His Cys Glu Pro Gly Tyr Glu Glu Gly Gly
            260                 265                 270         
Ser Gly Glu Ala Cys Val Ala Cys Pro Ser Gly Ser Tyr Arg Met Asp
        275                 280                 285             
Met Asp Thr Pro His Cys Leu Thr Cys Pro Gln Gln Ser Thr Ala Glu
    290                 295                 300                 
Ser Glu Gly Ala Thr Ile Cys Thr Cys Glu Ser Gly His Tyr Arg Ala
305                 310                 315                 320 
Pro Gly Glu Gly Pro Gln Val Ala Cys Thr Gly Pro Pro Ser Ala Pro
                325                 330                 335     
Arg Asn Leu Ser Phe Ser Ala Ser Gly Thr Gln Leu Ser Leu Arg Trp
            340                 345                 350         
Glu Pro Pro Ala Asp Thr Gly Gly Arg Gln Asp Val Arg Tyr Ser Val
        355                 360                 365             
Arg Cys Ser Gln Cys Gln Gly Thr Ala Gln Asp Gly Gly Pro Cys Gln
    370                 375                 380                 
Pro Cys Gly Val Gly Val His Phe Ser Pro Gly Ala Arg Gly Leu Thr
385                 390                 395                 400 
Thr Pro Ala Val His Val Asn Gly Leu Glu Pro Tyr Ala Asn Tyr Thr
                405                 410                 415     
Phe Asn Val Glu Ala Gln Asn Gly Val Ser Gly Leu Gly Ser Ser Gly
            420                 425                 430         
His Ala Ser Thr Ser Val Ser Ile Ser Met Gly His Ala Glu Ser Leu
        435                 440                 445             
Ser Gly Leu Ser Leu Arg Leu Val Lys Lys Glu Pro Arg Gln Leu Glu
    450                 455                 460                 
Leu Thr Trp Ala Gly Ser Arg Pro Arg Ser Pro Gly Ala Asn Leu Thr
465                 470                 475                 480 
Tyr Glu Leu His Val Leu Asn Gln Asp Glu Glu Arg Tyr Gln Met Val
                485                 490                 495     
Leu Glu Pro Arg Val Leu Leu Thr Glu Leu Gln Pro Asp Thr Thr Tyr
            500                 505                 510         
Ile Val Arg Val Arg Met Leu Thr Pro Leu Gly Pro Gly Pro Phe Ser
        515                 520                 525             
Pro Asp His Glu Phe Arg Thr Ser Pro Pro Val Ser Arg Gly Leu Thr
    530                 535                 540                 
Gly Gly Glu Ile Val Ala Val Ile Phe Gly Leu Leu Leu Gly Ala Ala
545                 550                 555                 560 
Leu Leu Leu Gly Ile Leu Val Phe Arg Ser Arg Arg Ala Gln Arg Gln
                565                 570                 575     
Arg Gln Gln Arg Gln Arg Asp Arg Ala Thr Asp Val Asp Arg Glu Asp
            580                 585                 590         
Lys Leu Trp Leu Lys Pro Tyr Val Asp Leu Gln Ala Tyr Glu Asp Pro
        595                 600                 605             
Ala Gln Gly Ala Leu Asp Phe Thr Arg Glu Leu Asp Pro Ala Trp Leu
    610                 615                 620                 
Met Val Asp Thr Val Ile Gly Glu Gly Glu Phe Gly Glu Val Tyr Arg
625                 630                 635                 640 
Gly Thr Leu Arg Leu Pro Ser Gln Asp Cys Lys Thr Val Ala Ile Lys
                645                 650                 655     
Thr Leu Lys Asp Thr Ser Pro Gly Gly Gln Trp Trp Asn Phe Leu Arg
            660                 665                 670         
Glu Ala Thr Ile Met Gly Gln Phe Ser His Pro His Ile Leu His Leu
        675                 680                 685             
Glu Gly Val Val Thr Lys Arg Lys Pro Ile Met Ile Ile Thr Glu Phe
    690                 695                 700                 
Met Glu Asn Gly Ala Leu Asp Ala Phe Leu Arg Glu Arg Glu Asp Gln
705                 710                 715                 720 
Leu Val Pro Gly Gln Leu Val Ala Met Leu Gln Gly Ile Ala Ser Gly
                725                 730                 735     
Met Asn Tyr Leu Ser Asn His Asn Tyr Val His Arg Asp Leu Ala Ala
            740                 745                 750         
Arg Asn Ile Leu Val Asn Gln Asn Leu Cys Cys Lys Val Ser Asp Phe
        755                 760                 765             
Gly Leu Thr Arg Leu Leu Asp Asp Phe Asp Gly Thr Tyr Glu Thr Gln
    770                 775                 780                 
Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala His
785                 790                 795                 800 
Arg Ile Phe Thr Thr Ala Ser Asp Val Trp Ser Phe Gly Ile Val Met
                805                 810                 815     
Trp Glu Val Leu Ser Phe Gly Asp Lys Pro Tyr Gly Glu Met Ser Asn
            820                 825                 830         
Gln Glu Val Met Lys Ser Ile Glu Asp Gly Tyr Arg Leu Pro Pro Pro
        835                 840                 845             
Val Asp Cys Pro Ala Pro Leu Tyr Glu Leu Met Lys Asn Cys Trp Ala
    850                 855                 860                 
Tyr Asp Arg Ala Arg Arg Pro His Phe Gln Lys Leu Gln Ala His Leu
865                 870                 875                 880 
Glu Gln Leu Leu Ala Asn Pro His Ser Leu Arg Thr Ile Ala Asn Phe
                885                 890                 895     
Asp Pro Arg Met Thr Leu Arg Leu Pro Ser Leu Ser Gly Ser Asp Gly
            900                 905                 910         
Ile Pro Tyr Arg Thr Val Ser Glu Trp Leu Glu Ser Ile Arg Met Lys
        915                 920                 925             
Arg Tyr Ile Leu His Phe His Ser Ala Gly Leu Asp Thr Met Glu Cys
    930                 935                 940                 
Val Leu Glu Leu Thr Ala Glu Asp Leu Thr Gln Met Gly Ile Thr Leu
945                 950                 955                 960 
Pro Gly His Gln Lys Arg Ile Leu Cys Ser Ile Gln Gly Phe Lys Asp
                965                 970                 975     


<210> 432
<211> 976
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 94
<223> Xaa = I or N

<220> 
<221> VARIANT        
<222> 96
<223> Xaa = I or F

<220> 
<221> VARIANT        
<222> 99
<223> Xaa = K or N

<220> 
<221> VARIANT        
<222> 350
<223> Xaa = P or T

<220> 
<221> VARIANT        
<222> 825
<223> Xaa = E or K

<400> 432
Met Glu Leu Gln Ala Ala Arg Ala Cys Phe Ala Leu Leu Trp Gly Cys
 1               5                  10                  15      
Ala Leu Ala Ala Ala Ala Ala Ala Gln Gly Lys Glu Val Val Leu Leu
            20                  25                  30          
Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly Trp Leu Thr His Pro Tyr
        35                  40                  45              
Gly Lys Gly Trp Asp Leu Met Gln Asn Ile Met Asn Asp Met Pro Ile
    50                  55                  60                  
Tyr Met Tyr Ser Val Cys Asn Val Met Ser Gly Asp Gln Asp Asn Trp
65                  70                  75                  80  
Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu Ala Glu Arg Xaa Phe Xaa
                85                  90                  95      
Glu Leu Xaa Phe Thr Val Arg Asp Cys Asn Ser Phe Pro Gly Gly Ala
            100                 105                 110         
Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Ala Glu Ser Asp Leu
        115                 120                 125             
Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu Phe Thr Lys Ile Asp Thr
    130                 135                 140                 
Ile Ala Pro Asp Glu Ile Thr Val Ser Ser Asp Phe Glu Ala Arg His
145                 150                 155                 160 
Val Lys Leu Asn Val Glu Glu Arg Ser Val Gly Pro Leu Thr Arg Lys
                165                 170                 175     
Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Val Ala Leu Leu
            180                 185                 190         
Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Glu Leu Leu Gln Gly Leu
        195                 200                 205             
Ala His Phe Pro Glu Thr Ile Ala Gly Ser Asp Ala Pro Ser Leu Ala
    210                 215                 220                 
Thr Val Ala Gly Thr Cys Val Asp His Ala Val Val Pro Pro Gly Gly
225                 230                 235                 240 
Glu Glu Pro Arg Met His Cys Ala Val Asp Gly Glu Trp Leu Val Pro
                245                 250                 255     
Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr Glu Lys Val Glu Asp Ala
            260                 265                 270         
Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys Phe Glu Ala Ser Glu Ser
        275                 280                 285             
Pro Cys Leu Glu Cys Pro Glu His Thr Leu Pro Ser Pro Glu Gly Ala
    290                 295                 300                 
Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe Arg Ala Pro Gln Asp Pro
305                 310                 315                 320 
Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro His Tyr Leu Thr
                325                 330                 335     
Ala Val Gly Met Gly Ala Lys Val Glu Leu Arg Trp Thr Xaa Pro Gln
            340                 345                 350         
Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr Ser Val Thr Cys Glu Gln
        355                 360                 365             
Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro Cys Glu Ala Ser Val Arg
    370                 375                 380                 
Tyr Ser Glu Pro Pro His Gly Leu Thr Arg Thr Ser Val Thr Val Ser
385                 390                 395                 400 
Asp Leu Glu Pro His Met Asn Tyr Thr Phe Thr Val Glu Ala Arg Asn
                405                 410                 415     
Gly Val Ser Gly Leu Val Thr Ser Arg Ser Phe Arg Thr Ala Ser Val
            420                 425                 430         
Ser Ile Asn Gln Thr Glu Pro Pro Lys Val Arg Leu Glu Gly Arg Ser
        435                 440                 445             
Thr Thr Ser Leu Ser Val Ser Trp Ser Ile Pro Pro Pro Gln Gln Ser
    450                 455                 460                 
Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg Lys Lys Gly Asp Ser Asn
465                 470                 475                 480 
Ser Tyr Asn Val Arg Arg Thr Glu Gly Phe Ser Val Thr Leu Asp Asp
                485                 490                 495     
Leu Ala Pro Asp Thr Thr Tyr Leu Val Gln Val Gln Ala Leu Thr Gln
            500                 505                 510         
Glu Gly Gln Gly Ala Gly Ser Lys Val His Glu Phe Gln Thr Leu Ser
        515                 520                 525             
Pro Glu Gly Ser Gly Asn Leu Ala Val Ile Gly Gly Val Ala Val Gly
    530                 535                 540                 
Val Val Leu Leu Leu Val Leu Ala Gly Val Gly Phe Phe Ile His Arg
545                 550                 555                 560 
Arg Arg Lys Asn Gln Arg Ala Arg Gln Ser Pro Glu Asp Val Tyr Phe
                565                 570                 575     
Ser Lys Ser Glu Gln Leu Lys Pro Leu Lys Thr Tyr Val Asp Pro His
            580                 585                 590         
Thr Tyr Glu Asp Pro Asn Gln Ala Val Leu Lys Phe Thr Thr Glu Ile
        595                 600                 605             
His Pro Ser Cys Val Thr Arg Gln Lys Val Ile Gly Ala Gly Glu Phe
    610                 615                 620                 
Gly Glu Val Tyr Lys Gly Met Leu Lys Thr Ser Ser Gly Lys Lys Glu
625                 630                 635                 640 
Val Pro Val Ala Ile Lys Thr Leu Lys Ala Gly Tyr Thr Glu Lys Gln
                645                 650                 655     
Arg Val Asp Phe Leu Gly Glu Ala Gly Ile Met Gly Gln Phe Ser His
            660                 665                 670         
His Asn Ile Ile Arg Leu Glu Gly Val Ile Ser Lys Tyr Lys Pro Met
        675                 680                 685             
Met Ile Ile Thr Glu Tyr Met Glu Asn Gly Ala Leu Asp Lys Phe Leu
    690                 695                 700                 
Arg Glu Lys Asp Gly Glu Phe Ser Val Leu Gln Leu Val Gly Met Leu
705                 710                 715                 720 
Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Asn Met Asn Tyr Val
                725                 730                 735     
His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val
            740                 745                 750         
Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro
        755                 760                 765             
Glu Ala Thr Tyr Thr Thr Ser Gly Gly Lys Ile Pro Ile Arg Trp Thr
    770                 775                 780                 
Ala Pro Glu Ala Ile Ser Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val
785                 790                 795                 800 
Trp Ser Phe Gly Ile Val Met Trp Glu Val Met Thr Tyr Gly Glu Arg
                805                 810                 815     
Pro Tyr Trp Glu Leu Ser Asn His Xaa Val Met Lys Ala Ile Asn Asp
            820                 825                 830         
Gly Phe Arg Leu Pro Thr Pro Met Asp Cys Pro Ser Ala Ile Tyr Gln
        835                 840                 845             
Leu Met Met Gln Cys Trp Gln Gln Glu Arg Ala Arg Arg Pro Lys Phe
    850                 855                 860                 
Ala Asp Ile Val Ser Ile Leu Asp Lys Leu Ile Arg Ala Pro Asp Ser
865                 870                 875                 880 
Leu Lys Thr Leu Ala Asp Phe Asp Pro Arg Val Ser Ile Arg Leu Pro
                885                 890                 895     
Ser Thr Ser Gly Ser Glu Gly Val Pro Phe Arg Thr Val Ser Glu Trp
            900                 905                 910         
Leu Glu Ser Ile Lys Met Gln Gln Tyr Thr Glu His Phe Met Ala Ala
        915                 920                 925             
Gly Tyr Thr Ala Ile Glu Lys Val Val Gln Met Thr Asn Asp Asp Ile
    930                 935                 940                 
Lys Arg Ile Gly Val Arg Leu Pro Gly His Gln Lys Arg Ile Ala Tyr
945                 950                 955                 960 
Ser Leu Leu Gly Leu Lys Asp Gln Val Asn Thr Val Gly Ile Pro Ile
                965                 970                 975     


<210> 433
<211> 983
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 914
<223> Xaa = R or H

<400> 433
Met Asp Cys Gln Leu Ser Ile Leu Leu Leu Leu Ser Cys Ser Val Leu
 1               5                  10                  15      
Asp Ser Phe Gly Glu Leu Ile Pro Gln Pro Ser Asn Glu Val Asn Leu
            20                  25                  30          
Leu Asp Ser Lys Thr Ile Gln Gly Glu Leu Gly Trp Ile Ser Tyr Pro
        35                  40                  45              
Ser His Gly Trp Glu Glu Ile Ser Gly Val Asp Glu His Tyr Thr Pro
    50                  55                  60                  
Ile Arg Thr Tyr Gln Val Cys Asn Val Met Asp His Ser Gln Asn Asn
65                  70                  75                  80  
Trp Leu Arg Thr Asn Trp Val Pro Arg Asn Ser Ala Gln Lys Ile Tyr
                85                  90                  95      
Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Ile Pro Leu Val
            100                 105                 110         
Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Met Glu Ser Asp
        115                 120                 125             
Asp Asp His Gly Val Lys Phe Arg Glu His Gln Phe Thr Lys Ile Asp
    130                 135                 140                 
Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Met Asp Leu Gly Asp Arg
145                 150                 155                 160 
Ile Leu Lys Leu Asn Thr Glu Ile Arg Glu Val Gly Pro Val Asn Lys
                165                 170                 175     
Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Val Ala Leu
            180                 185                 190         
Val Ser Val Arg Val Tyr Phe Lys Lys Cys Pro Phe Thr Val Lys Asn
        195                 200                 205             
Leu Ala Met Phe Pro Asp Thr Val Pro Met Asp Ser Gln Ser Leu Val
    210                 215                 220                 
Glu Val Arg Gly Ser Cys Val Asn Asn Ser Lys Glu Glu Asp Pro Pro
225                 230                 235                 240 
Arg Met Tyr Cys Ser Thr Glu Gly Glu Trp Leu Val Pro Ile Gly Lys
                245                 250                 255     
Cys Ser Cys Asn Ala Gly Tyr Glu Glu Arg Gly Phe Met Cys Gln Ala
            260                 265                 270         
Cys Arg Pro Gly Phe Tyr Lys Ala Leu Asp Gly Asn Met Lys Cys Ala
        275                 280                 285             
Lys Cys Pro Pro His Ser Ser Thr Gln Glu Asp Gly Ser Met Asn Cys
    290                 295                 300                 
Arg Cys Glu Asn Asn Tyr Phe Arg Ala Asp Lys Asp Pro Pro Ser Met
305                 310                 315                 320 
Ala Cys Thr Arg Pro Pro Ser Ser Pro Arg Asn Val Ile Ser Asn Ile
                325                 330                 335     
Asn Glu Thr Ser Val Ile Leu Asp Trp Ser Trp Pro Leu Asp Thr Gly
            340                 345                 350         
Gly Arg Lys Asp Val Thr Phe Asn Ile Ile Cys Lys Lys Cys Gly Trp
        355                 360                 365             
Asn Ile Lys Gln Cys Glu Pro Cys Ser Pro Asn Val Arg Phe Leu Pro
    370                 375                 380                 
Arg Gln Phe Gly Leu Thr Asn Thr Thr Val Thr Val Thr Asp Leu Leu
385                 390                 395                 400 
Ala His Thr Asn Tyr Thr Phe Glu Ile Asp Ala Val Asn Gly Val Ser
                405                 410                 415     
Glu Leu Ser Ser Pro Pro Arg Gln Phe Ala Ala Val Ser Ile Thr Thr
            420                 425                 430         
Asn Gln Ala Ala Pro Ser Pro Val Leu Thr Ile Lys Lys Asp Arg Thr
        435                 440                 445             
Ser Arg Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Glu His Pro Asn
    450                 455                 460                 
Gly Ile Ile Leu Asp Tyr Glu Val Lys Tyr Tyr Glu Lys Gln Glu Gln
465                 470                 475                 480 
Glu Thr Ser Tyr Thr Ile Leu Arg Ala Arg Gly Thr Asn Val Thr Ile
                485                 490                 495     
Ser Ser Leu Lys Pro Asp Thr Ile Tyr Val Phe Gln Ile Arg Ala Arg
            500                 505                 510         
Thr Ala Ala Gly Tyr Gly Thr Asn Ser Arg Lys Phe Glu Phe Glu Thr
        515                 520                 525             
Ser Pro Asp Ser Phe Ser Ile Ser Gly Glu Ser Ser Gln Val Val Met
    530                 535                 540                 
Ile Ala Ile Ser Ala Ala Val Ala Ile Ile Leu Leu Thr Val Val Ile
545                 550                 555                 560 
Tyr Val Leu Ile Gly Arg Phe Cys Gly Tyr Lys Ser Lys His Gly Ala
                565                 570                 575     
Asp Glu Lys Arg Leu His Phe Gly Asn Gly His Leu Lys Leu Pro Gly
            580                 585                 590         
Leu Arg Thr Tyr Val Asp Pro His Thr Tyr Glu Asp Pro Thr Gln Ala
        595                 600                 605             
Val His Glu Phe Ala Lys Glu Leu Asp Ala Thr Asn Ile Ser Ile Asp
    610                 615                 620                 
Lys Val Val Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu
625                 630                 635                 640 
Lys Leu Pro Ser Lys Lys Glu Ile Ser Val Ala Ile Lys Thr Leu Lys
                645                 650                 655     
Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Gly Glu Ala Ser
            660                 665                 670         
Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val
        675                 680                 685             
Val Thr Lys Ser Lys Pro Val Met Ile Val Thr Glu Tyr Met Glu Asn
    690                 695                 700                 
Gly Ser Leu Asp Ser Phe Leu Arg Lys His Asp Ala Gln Phe Thr Val
705                 710                 715                 720 
Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ser Gly Met Lys Tyr
                725                 730                 735     
Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile
            740                 745                 750         
Leu Ile Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser
        755                 760                 765             
Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly
    770                 775                 780                 
Lys Ile Pro Ile Arg Trp Thr Ser Pro Glu Ala Ile Ala Tyr Arg Lys
785                 790                 795                 800 
Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Leu Trp Glu
                805                 810                 815     
Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Glu Met Ser Asn Gln Asp
            820                 825                 830         
Val Ile Lys Ala Val Asp Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp
        835                 840                 845             
Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu Asp Cys Trp Gln Lys Asp
    850                 855                 860                 
Arg Asn Asn Arg Pro Lys Phe Glu Gln Ile Val Ser Ile Leu Asp Lys
865                 870                 875                 880 
Leu Ile Arg Asn Pro Gly Ser Leu Lys Ile Ile Thr Ser Ala Ala Ala
                885                 890                 895     
Arg Pro Ser Asn Leu Leu Leu Asp Gln Ser Asn Val Asp Ile Thr Thr
            900                 905                 910         
Phe Xaa Thr Thr Gly Asp Trp Leu Asn Gly Val Trp Thr Ala His Cys
        915                 920                 925             
Lys Glu Ile Phe Thr Gly Val Glu Tyr Ser Ser Cys Asp Thr Ile Ala
    930                 935                 940                 
Lys Ile Ser Thr Asp Asp Met Lys Lys Val Gly Val Thr Val Val Gly
945                 950                 955                 960 
Pro Gln Lys Lys Ile Ile Ser Ser Ile Lys Ala Leu Glu Thr Gln Ser
                965                 970                 975     
Lys Asn Gly Pro Val Pro Val
            980             


<210> 434
<211> 998
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 138
<223> Xaa = I or V

<220> 
<221> VARIANT        
<222> 278
<223> Xaa = P or S

<400> 434
Met Val Phe Gln Thr Arg Tyr Pro Ser Trp Ile Ile Leu Cys Tyr Ile
 1               5                  10                  15      
Trp Leu Leu Arg Phe Ala His Thr Gly Glu Ala Gln Ala Ala Lys Glu
            20                  25                  30          
Val Leu Leu Leu Asp Ser Lys Ala Gln Gln Thr Glu Leu Glu Trp Ile
        35                  40                  45              
Ser Ser Pro Pro Asn Gly Trp Glu Glu Ile Ser Gly Leu Asp Glu Asn
    50                  55                  60                  
Tyr Thr Pro Ile Arg Thr Tyr Gln Val Cys Gln Val Met Glu Pro Asn
65                  70                  75                  80  
Gln Asn Asn Trp Leu Arg Thr Asn Trp Ile Ser Lys Gly Asn Ala Gln
                85                  90                  95      
Arg Ile Phe Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu
            100                 105                 110         
Pro Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr
        115                 120                 125             
Glu Thr Asp Tyr Asp Thr Gly Arg Asn Xaa Arg Glu Asn Leu Tyr Val
    130                 135                 140                 
Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Gly Asp Leu
145                 150                 155                 160 
Gly Glu Arg Lys Met Lys Leu Asn Thr Glu Val Arg Glu Ile Gly Pro
                165                 170                 175     
Leu Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys
            180                 185                 190         
Ile Ala Leu Val Ser Val Lys Val Tyr Tyr Lys Lys Cys Trp Ser Ile
        195                 200                 205             
Ile Glu Asn Leu Ala Ile Phe Pro Asp Thr Val Thr Gly Ser Glu Phe
    210                 215                 220                 
Ser Ser Leu Val Glu Val Arg Gly Thr Cys Val Ser Ser Ala Glu Glu
225                 230                 235                 240 
Glu Ala Glu Asn Ala Pro Arg Met His Cys Ser Ala Glu Gly Glu Trp
                245                 250                 255     
Leu Val Pro Ile Gly Lys Cys Ile Cys Lys Ala Gly Tyr Gln Gln Lys
            260                 265                 270         
Gly Asp Thr Cys Glu Xaa Cys Gly Arg Gly Phe Tyr Lys Ser Ser Ser
        275                 280                 285             
Gln Asp Leu Gln Cys Ser Arg Cys Pro Thr His Ser Phe Ser Asp Lys
    290                 295                 300                 
Glu Gly Ser Ser Arg Cys Glu Cys Glu Asp Gly Tyr Tyr Arg Ala Pro
305                 310                 315                 320 
Ser Asp Pro Pro Tyr Val Ala Cys Thr Arg Pro Pro Ser Ala Pro Gln
                325                 330                 335     
Asn Leu Ile Phe Asn Ile Asn Gln Thr Thr Val Ser Leu Glu Trp Ser
            340                 345                 350         
Pro Pro Ala Asp Asn Gly Gly Arg Asn Asp Val Thr Tyr Arg Ile Leu
        355                 360                 365             
Cys Lys Arg Cys Ser Trp Glu Gln Gly Glu Cys Val Pro Cys Gly Ser
    370                 375                 380                 
Asn Ile Gly Tyr Met Pro Gln Gln Thr Gly Leu Glu Asp Asn Tyr Val
385                 390                 395                 400 
Thr Val Met Asp Leu Leu Ala His Ala Asn Tyr Thr Phe Glu Val Glu
                405                 410                 415     
Ala Val Asn Gly Val Ser Asp Leu Ser Arg Ser Gln Arg Leu Phe Ala
            420                 425                 430         
Ala Val Ser Ile Thr Thr Gly Gln Ala Ala Pro Ser Gln Val Ser Gly
        435                 440                 445             
Val Met Lys Glu Arg Val Leu Gln Arg Ser Val Glu Leu Ser Trp Gln
    450                 455                 460                 
Glu Pro Glu His Pro Asn Gly Val Ile Thr Glu Tyr Glu Ile Lys Tyr
465                 470                 475                 480 
Tyr Glu Lys Asp Gln Arg Glu Arg Thr Tyr Ser Thr Val Lys Thr Lys
                485                 490                 495     
Ser Thr Ser Ala Ser Ile Asn Asn Leu Lys Pro Gly Thr Val Tyr Val
            500                 505                 510         
Phe Gln Ile Arg Ala Phe Thr Ala Ala Gly Tyr Gly Asn Tyr Ser Pro
        515                 520                 525             
Arg Leu Asp Val Ala Thr Leu Glu Glu Ala Thr Gly Lys Met Phe Glu
    530                 535                 540                 
Ala Thr Ala Val Ser Ser Glu Gln Asn Pro Val Ile Ile Ile Ala Val
545                 550                 555                 560 
Val Ala Val Ala Gly Thr Ile Ile Leu Val Phe Met Val Phe Gly Phe
                565                 570                 575     
Ile Ile Gly Arg Arg His Cys Gly Tyr Ser Lys Ala Asp Gln Glu Gly
            580                 585                 590         
Asp Glu Glu Leu Tyr Phe His Phe Lys Phe Pro Gly Thr Lys Thr Tyr
        595                 600                 605             
Ile Asp Pro Glu Thr Tyr Glu Asp Pro Asn Arg Ala Val His Gln Phe
    610                 615                 620                 
Ala Lys Glu Leu Asp Ala Ser Cys Ile Lys Ile Glu Arg Val Ile Gly
625                 630                 635                 640 
Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu Lys Leu Pro Gly
                645                 650                 655     
Lys Arg Asp Val Ala Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr
            660                 665                 670         
Glu Lys Gln Arg Arg Asp Phe Leu Cys Glu Ala Ser Ile Met Gly Gln
        675                 680                 685             
Phe Asp His Pro Asn Val Val His Leu Glu Gly Val Val Thr Arg Gly
    690                 695                 700                 
Lys Pro Val Met Ile Val Ile Glu Phe Met Glu Asn Gly Ala Leu Asp
705                 710                 715                 720 
Ala Phe Leu Arg Lys His Asp Gly Gln Phe Thr Val Ile Gln Leu Val
                725                 730                 735     
Gly Met Leu Arg Gly Ile Ala Ala Gly Met Arg Tyr Leu Ala Asp Met
            740                 745                 750         
Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser
        755                 760                 765             
Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Ile Glu
    770                 775                 780                 
Asp Asp Pro Glu Ala Val Tyr Thr Thr Thr Gly Gly Lys Ile Pro Val
785                 790                 795                 800 
Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr Arg Lys Phe Thr Ser Ala
                805                 810                 815     
Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Tyr
            820                 825                 830         
Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Lys Ala
        835                 840                 845             
Ile Glu Glu Gly Tyr Arg Leu Pro Ala Pro Met Asp Cys Pro Ala Gly
    850                 855                 860                 
Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu Arg Ala Glu Arg
865                 870                 875                 880 
Pro Lys Phe Glu Gln Ile Val Gly Ile Leu Asp Lys Met Ile Arg Asn
                885                 890                 895     
Pro Asn Ser Leu Lys Thr Pro Leu Gly Thr Cys Ser Arg Pro Ile Ser
            900                 905                 910         
Pro Leu Leu Asp Gln Asn Thr Pro Asp Phe Thr Thr Phe Cys Ser Val
        915                 920                 925             
Gly Glu Trp Leu Gln Ala Ile Lys Met Glu Arg Tyr Lys Asp Asn Phe
    930                 935                 940                 
Thr Ala Ala Gly Tyr Asn Ser Leu Glu Ser Val Ala Arg Met Thr Ile
945                 950                 955                 960 
Glu Asp Val Met Ser Leu Gly Ile Thr Leu Val Gly His Gln Lys Lys
                965                 970                 975     
Ile Met Ser Ser Ile Gln Thr Met Arg Ala Gln Met Leu His Leu His
            980                 985                 990         
Gly Thr Gly Ile Gln Val
        995             


<210> 435
<211> 1005
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 301
<223> Xaa = A or V

<220> 
<221> VARIANT        
<222> 444
<223> Xaa = V or M

<220> 
<221> VARIANT        
<222> 612
<223> Xaa = E or Q

<400> 435
Met Ala Pro Ala Arg Gly Arg Leu Pro Pro Ala Leu Trp Val Val Thr
 1               5                  10                  15      
Ala Ala Ala Ala Ala Ala Thr Cys Val Ser Ala Ala Arg Gly Glu Val
            20                  25                  30          
Asn Leu Leu Asp Thr Ser Thr Ile His Gly Asp Trp Gly Trp Leu Thr
        35                  40                  45              
Tyr Pro Ala His Gly Trp Asp Ser Ile Asn Glu Val Asp Glu Ser Phe
    50                  55                  60                  
Gln Pro Ile His Thr Tyr Gln Val Cys Asn Val Met Ser Pro Asn Gln
65                  70                  75                  80  
Asn Asn Trp Leu Arg Thr Ser Trp Val Pro Arg Asp Gly Ala Arg Arg
                85                  90                  95      
Val Tyr Ala Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Met Pro
            100                 105                 110         
Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Leu Glu
        115                 120                 125             
Ser Asp Arg Asp Leu Gly Ala Ser Thr Gln Glu Ser Gln Phe Leu Lys
    130                 135                 140                 
Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gly Ala Asp Leu Gly
145                 150                 155                 160 
Val Arg Arg Leu Lys Leu Asn Thr Glu Val Arg Ser Val Gly Pro Leu
                165                 170                 175     
Ser Lys Arg Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Leu
            180                 185                 190         
Ala Ile Leu Ser Leu Arg Ile Tyr Tyr Lys Lys Cys Pro Ala Met Val
        195                 200                 205             
Arg Asn Leu Ala Ala Phe Ser Glu Ala Val Thr Gly Ala Asp Ser Ser
    210                 215                 220                 
Ser Leu Val Glu Val Arg Gly Gln Cys Val Arg His Ser Glu Glu Arg
225                 230                 235                 240 
Asp Thr Pro Lys Met Tyr Cys Ser Ala Glu Gly Glu Trp Leu Val Pro
                245                 250                 255     
Ile Gly Lys Cys Val Cys Ser Ala Gly Tyr Glu Glu Arg Arg Asp Ala
            260                 265                 270         
Cys Val Ala Cys Glu Leu Gly Phe Tyr Lys Ser Ala Pro Gly Asp Gln
        275                 280                 285             
Leu Cys Ala Arg Cys Pro Pro His Ser His Ser Ala Xaa Pro Ala Ala
    290                 295                 300                 
Gln Ala Cys His Cys Asp Leu Ser Tyr Tyr Arg Ala Ala Leu Asp Pro
305                 310                 315                 320 
Pro Ser Ser Ala Cys Thr Arg Pro Pro Ser Ala Pro Val Asn Leu Ile
                325                 330                 335     
Ser Ser Val Asn Gly Thr Ser Val Thr Leu Glu Trp Ala Pro Pro Leu
            340                 345                 350         
Asp Pro Gly Gly Arg Ser Asp Ile Thr Tyr Asn Ala Val Cys Arg Arg
        355                 360                 365             
Cys Pro Trp Ala Leu Ser Arg Cys Glu Ala Cys Gly Ser Gly Thr Arg
    370                 375                 380                 
Phe Val Pro Gln Gln Thr Ser Leu Val Gln Ala Ser Leu Leu Val Ala
385                 390                 395                 400 
Asn Leu Leu Ala His Met Asn Tyr Ser Phe Trp Ile Glu Ala Val Asn
                405                 410                 415     
Gly Val Ser Asp Leu Ser Pro Glu Pro Arg Arg Ala Ala Val Val Asn
            420                 425                 430         
Ile Thr Thr Asn Gln Ala Ala Pro Ser Gln Val Xaa Val Ile Arg Gln
        435                 440                 445             
Glu Arg Ala Gly Gln Thr Ser Val Ser Leu Leu Trp Gln Glu Pro Glu
    450                 455                 460                 
Gln Pro Asn Gly Ile Ile Leu Glu Tyr Glu Ile Lys Tyr Tyr Glu Lys
465                 470                 475                 480 
Asp Lys Glu Met Gln Ser Tyr Ser Thr Leu Lys Ala Val Thr Thr Arg
                485                 490                 495     
Ala Thr Val Ser Gly Leu Lys Pro Gly Thr Arg Tyr Val Phe Gln Val
            500                 505                 510         
Arg Ala Arg Thr Ser Ala Gly Cys Gly Arg Phe Ser Gln Ala Met Glu
        515                 520                 525             
Val Glu Thr Gly Lys Pro Arg Pro Arg Tyr Asp Thr Arg Thr Ile Val
    530                 535                 540                 
Trp Ile Cys Leu Thr Leu Ile Thr Gly Leu Val Val Leu Leu Leu Leu
545                 550                 555                 560 
Leu Ile Cys Lys Lys Arg His Cys Gly Tyr Ser Lys Ala Phe Gln Asp
                565                 570                 575     
Ser Asp Glu Glu Lys Met His Tyr Gln Asn Gly Gln Ala Pro Pro Pro
            580                 585                 590         
Val Phe Leu Pro Leu His His Pro Pro Gly Lys Leu Pro Glu Pro Gln
        595                 600                 605             
Phe Tyr Ala Xaa Pro His Thr Tyr Glu Glu Pro Gly Arg Ala Gly Arg
    610                 615                 620                 
Ser Phe Thr Arg Glu Ile Glu Ala Ser Arg Ile His Ile Glu Lys Ile
625                 630                 635                 640 
Ile Gly Ser Gly Asp Ser Gly Glu Val Cys Tyr Gly Arg Leu Arg Val
                645                 650                 655     
Pro Gly Gln Arg Asp Val Pro Val Ala Ile Lys Ala Leu Lys Ala Gly
            660                 665                 670         
Tyr Thr Glu Arg Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met
        675                 680                 685             
Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr
    690                 695                 700                 
Arg Gly Arg Leu Ala Met Ile Val Thr Glu Tyr Met Glu Asn Gly Ser
705                 710                 715                 720 
Leu Asp Thr Phe Leu Arg Thr His Asp Gly Gln Phe Thr Ile Met Gln
                725                 730                 735     
Leu Val Gly Met Leu Arg Gly Val Gly Ala Gly Met Arg Tyr Leu Ser
            740                 745                 750         
Asp Leu Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val
        755                 760                 765             
Asp Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val
    770                 775                 780                 
Leu Glu Asp Asp Pro Asp Ala Ala Tyr Thr Thr Thr Gly Gly Lys Ile
785                 790                 795                 800 
Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Thr Phe Ser
                805                 810                 815     
Ser Ala Ser Asp Val Trp Ser Phe Gly Val Val Met Trp Glu Val Leu
            820                 825                 830         
Ala Tyr Gly Glu Arg Pro Tyr Trp Asn Met Thr Asn Arg Asp Val Ile
        835                 840                 845             
Ser Ser Val Glu Glu Gly Tyr Arg Leu Pro Ala Pro Met Gly Cys Pro
    850                 855                 860                 
His Ala Leu His Gln Leu Met Leu Asp Cys Trp His Lys Asp Arg Ala
865                 870                 875                 880 
Gln Arg Pro Arg Phe Ser Gln Ile Val Ser Val Leu Asp Ala Leu Ile
                885                 890                 895     
Arg Ser Pro Glu Ser Leu Arg Ala Thr Ala Thr Val Ser Arg Cys Pro
            900                 905                 910         
Pro Pro Ala Phe Val Arg Ser Cys Phe Asp Leu Arg Gly Gly Ser Gly
        915                 920                 925             
Gly Gly Gly Gly Leu Thr Val Gly Asp Trp Leu Asp Ser Ile Arg Met
    930                 935                 940                 
Gly Arg Tyr Arg Asp His Phe Ala Ala Gly Gly Tyr Ser Ser Leu Gly
945                 950                 955                 960 
Met Val Leu Arg Met Asn Ala Gln Asp Val Arg Ala Leu Gly Ile Thr
                965                 970                 975     
Leu Met Gly His Gln Lys Lys Ile Leu Gly Ser Ile Gln Thr Met Arg
            980                 985                 990         
Ala Gln Leu Thr Ser Thr Gln Gly Pro Arg Arg His Leu
        995                 1000                1005


<210> 436
<211> 984
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 87
<223> Xaa = T or S

<220> 
<221> VARIANT        
<222> 152, 367
<223> Xaa = G or R

<220> 
<221> VARIANT        
<222> 274
<223> Xaa = T or R

<220> 
<221> VARIANT        
<222> 485
<223> Xaa = R or S

<220> 
<221> VARIANT        
<222> 813
<223> Xaa = V or I

<220> 
<221> VARIANT        
<222> 847
<223> Xaa = M or T

<220> 
<221> VARIANT        
<222> 973
<223> Xaa = R or W

<400> 436
Met Ala Leu Asp Tyr Leu Leu Leu Leu Leu Leu Ala Ser Ala Val Ala
 1               5                  10                  15      
Ala Met Glu Glu Thr Leu Met Asp Thr Arg Thr Ala Thr Ala Glu Leu
            20                  25                  30          
Gly Trp Thr Ala Asn Pro Ala Ser Gly Trp Glu Glu Val Ser Gly Tyr
        35                  40                  45              
Asp Glu Asn Leu Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val Phe
    50                  55                  60                  
Glu Pro Asn Gln Asn Asn Trp Leu Leu Thr Thr Phe Ile Asn Arg Arg
65                  70                  75                  80  
Gly Ala His Arg Ile Tyr Xaa Glu Met Arg Phe Thr Val Arg Asp Cys
                85                  90                  95      
Ser Ser Leu Pro Asn Val Pro Gly Ser Cys Lys Glu Thr Phe Asn Leu
            100                 105                 110         
Tyr Tyr Tyr Glu Thr Asp Ser Val Ile Ala Thr Lys Lys Ser Ala Phe
        115                 120                 125             
Trp Ser Glu Ala Pro Tyr Leu Lys Val Asp Thr Ile Ala Ala Asp Glu
    130                 135                 140                 
Ser Phe Ser Gln Val Asp Phe Xaa Gly Arg Leu Met Lys Val Asn Thr
145                 150                 155                 160 
Glu Val Arg Ser Phe Gly Pro Leu Thr Arg Asn Gly Phe Tyr Leu Ala
                165                 170                 175     
Phe Gln Asp Tyr Gly Ala Cys Met Ser Leu Leu Ser Val Arg Val Phe
            180                 185                 190         
Phe Lys Lys Cys Pro Ser Ile Val Gln Asn Phe Ala Val Phe Pro Glu
        195                 200                 205             
Thr Met Thr Gly Ala Glu Ser Thr Ser Leu Val Ile Ala Arg Gly Thr
    210                 215                 220                 
Cys Ile Pro Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr Cys
225                 230                 235                 240 
Asn Gly Asp Gly Glu Trp Met Val Pro Ile Gly Arg Cys Thr Cys Lys
                245                 250                 255     
Pro Gly Tyr Glu Pro Glu Asn Ser Val Ala Cys Lys Ala Cys Pro Ala
            260                 265                 270         
Gly Xaa Phe Lys Ala Ser Gln Glu Ala Glu Gly Cys Ser His Cys Pro
        275                 280                 285             
Ser Asn Ser Arg Ser Pro Ala Glu Ala Ser Pro Ile Cys Thr Cys Arg
    290                 295                 300                 
Thr Gly Tyr Tyr Arg Ala Asp Phe Asp Pro Pro Glu Val Ala Cys Thr
305                 310                 315                 320 
Ser Val Pro Ser Gly Pro Arg Asn Val Ile Ser Ile Val Asn Glu Thr
                325                 330                 335     
Ser Ile Ile Leu Glu Trp His Pro Pro Arg Glu Thr Gly Gly Arg Asp
            340                 345                 350         
Asp Val Thr Tyr Asn Ile Ile Cys Lys Lys Cys Arg Ala Asp Xaa Arg
        355                 360                 365             
Ser Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro Arg Gln Leu
    370                 375                 380                 
Gly Leu Thr Glu Cys Arg Val Ser Ile Ser Ser Leu Trp Ala His Thr
385                 390                 395                 400 
Pro Tyr Thr Phe Asp Ile Gln Ala Ile Asn Gly Val Ser Ser Lys Ser
                405                 410                 415     
Pro Phe Pro Pro Gln His Val Ser Val Asn Ile Thr Thr Asn Gln Ala
            420                 425                 430         
Ala Pro Ser Thr Val Pro Ile Met His Gln Val Ser Ala Thr Met Arg
        435                 440                 445             
Ser Ile Thr Leu Ser Trp Pro Gln Pro Glu Gln Pro Asn Gly Ile Ile
    450                 455                 460                 
Leu Asp Tyr Glu Ile Arg Tyr Tyr Glu Lys Glu His Asn Glu Phe Asn
465                 470                 475                 480 
Ser Ser Met Ala Xaa Ser Gln Thr Asn Thr Ala Arg Ile Asp Gly Leu
                485                 490                 495     
Arg Pro Gly Met Val Tyr Val Val Gln Val Arg Ala Arg Thr Val Ala
            500                 505                 510         
Gly Tyr Gly Lys Phe Ser Gly Lys Met Cys Phe Gln Thr Leu Thr Asp
        515                 520                 525             
Asp Asp Tyr Lys Ser Glu Leu Arg Glu Gln Leu Pro Leu Ile Ala Gly
    530                 535                 540                 
Ser Ala Ala Ala Gly Val Val Phe Val Val Ser Leu Val Ala Ile Ser
545                 550                 555                 560 
Ile Val Cys Ser Arg Lys Arg Ala Tyr Ser Lys Glu Ala Val Tyr Ser
                565                 570                 575     
Asp Lys Leu Gln His Tyr Ser Thr Gly Arg Gly Ser Pro Gly Met Lys
            580                 585                 590         
Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg
        595                 600                 605             
Glu Phe Ala Lys Glu Ile Asp Val Ser Phe Val Lys Ile Glu Glu Val
    610                 615                 620                 
Ile Gly Ala Gly Glu Phe Gly Glu Val Tyr Lys Gly Arg Leu Lys Leu
625                 630                 635                 640 
Pro Gly Lys Arg Glu Ile Tyr Val Ala Ile Lys Thr Leu Lys Ala Gly
                645                 650                 655     
Tyr Ser Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met
            660                 665                 670         
Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr
        675                 680                 685             
Lys Ser Arg Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn Gly Ala
    690                 695                 700                 
Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val Ile Gln
705                 710                 715                 720 
Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala
                725                 730                 735     
Glu Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val
            740                 745                 750         
Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Tyr
        755                 760                 765             
Leu Gln Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly
    770                 775                 780                 
Lys Ile Pro Val Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys
785                 790                 795                 800 
Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Xaa Met Trp Glu
                805                 810                 815     
Val Met Ser Phe Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp
            820                 825                 830         
Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Xaa Asp
        835                 840                 845             
Cys Pro Ala Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp
    850                 855                 860                 
Arg Asn Ser Arg Pro Arg Phe Ala Glu Ile Val Asn Thr Leu Asp Lys
865                 870                 875                 880 
Met Ile Arg Asn Pro Ala Ser Leu Lys Thr Val Ala Thr Ile Thr Ala
                885                 890                 895     
Val Pro Ser Gln Pro Leu Leu Asp Arg Ser Ile Pro Asp Phe Thr Ala
            900                 905                 910         
Phe Thr Thr Val Asp Asp Trp Leu Ser Ala Ile Lys Met Val Gln Tyr
        915                 920                 925             
Arg Asp Ser Phe Leu Thr Ala Gly Phe Thr Ser Leu Gln Leu Val Thr
    930                 935                 940                 
Gln Met Thr Ser Glu Asp Leu Leu Arg Ile Gly Ile Thr Leu Ala Gly
945                 950                 955                 960 
His Gln Lys Lys Ile Leu Asn Ser Ile His Ser Met Xaa Val Gln Ile
                965                 970                 975     
Ser Gln Ser Pro Thr Ala Met Ala
            980                 


<210> 437
<211> 1055
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 923
<223> Xaa = E or K

<400> 437
Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu
 1               5                  10                  15      
Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu
            20                  25                  30          
Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly
        35                  40                  45              
Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val
    50                  55                  60                  
Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg
65                  70                  75                  80  
Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp
                85                  90                  95      
Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn
            100                 105                 110         
Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro
        115                 120                 125             
Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp
    130                 135                 140                 
Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn
145                 150                 155                 160 
Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu
                165                 170                 175     
Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val
            180                 185                 190         
Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln
        195                 200                 205             
Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly
    210                 215                 220                 
Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr
225                 230                 235                 240 
Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys
                245                 250                 255     
Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys
            260                 265                 270         
Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His
        275                 280                 285             
Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val
    290                 295                 300                 
Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro
305                 310                 315                 320 
Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn
                325                 330                 335     
Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly
            340                 345                 350         
Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly
        355                 360                 365             
Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg
    370                 375                 380                 
Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala
385                 390                 395                 400 
His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp
                405                 410                 415     
Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn
            420                 425                 430         
Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr
        435                 440                 445             
Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly
    450                 455                 460                 
Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu
465                 470                 475                 480 
Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln
                485                 490                 495     
Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr
            500                 505                 510         
Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met
        515                 520                 525             
Thr Glu Ala Glu Tyr Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile
    530                 535                 540                 
Ile Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val Val
545                 550                 555                 560 
Ile Ala Ile Val Cys Asn Arg Arg Gly Phe Glu Arg Ala Asp Ser Glu
                565                 570                 575     
Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro Gly
            580                 585                 590         
Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala
        595                 600                 605             
Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile Glu
    610                 615                 620                 
Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His Leu
625                 630                 635                 640 
Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu Lys
                645                 650                 655     
Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser
            660                 665                 670         
Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly Val
        675                 680                 685             
Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn
    690                 695                 700                 
Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val
705                 710                 715                 720 
Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr
                725                 730                 735     
Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile
            740                 745                 750         
Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser
        755                 760                 765             
Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala Leu
    770                 775                 780                 
Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr
785                 790                 795                 800 
Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met
                805                 810                 815     
Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr Asn
            820                 825                 830         
Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro
        835                 840                 845             
Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln
    850                 855                 860                 
Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr Leu
865                 870                 875                 880 
Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro Leu
                885                 890                 895     
Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp Tyr
            900                 905                 910         
Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Xaa Ala Ile Lys Met Gly
        915                 920                 925             
Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp Val
    930                 935                 940                 
Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr Leu
945                 950                 955                 960 
Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg Ala
                965                 970                 975     
Gln Met Asn Gln Ile Gln Ser Val Glu Gly Gln Pro Leu Ala Arg Arg
            980                 985                 990         
Pro Arg Ala Thr Gly Arg Thr Lys Arg Cys Gln Pro Arg Asp Val Thr
        995                 1000                1005            
Lys Lys Thr Cys Asn Ser Asn Asp Gly Lys Lys Lys Gly Met Gly Lys
    1010                1015                1020                
Lys Lys Thr Asp Pro Gly Arg Gly Arg Glu Ile Gln Gly Ile Phe Phe
1025                1030                1035                1040
Lys Glu Asp Ser His Lys Glu Ser Asn Asp Cys Ser Cys Gly Gly
                1045                1050                1055


<210> 438
<211> 998
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 981
<223> Xaa = S or I

<400> 438
Met Ala Arg Ala Arg Pro Pro Pro Pro Pro Ser Pro Pro Pro Gly Leu
 1               5                  10                  15      
Leu Pro Leu Leu Pro Pro Leu Leu Leu Leu Pro Leu Leu Leu Leu Pro
            20                  25                  30          
Ala Gly Cys Arg Ala Leu Glu Glu Thr Leu Met Asp Thr Lys Trp Val
        35                  40                  45              
Thr Ser Glu Leu Ala Trp Thr Ser His Pro Glu Ser Gly Trp Glu Glu
    50                  55                  60                  
Val Ser Gly Tyr Asp Glu Ala Met Asn Pro Ile Arg Thr Tyr Gln Val
65                  70                  75                  80  
Cys Asn Val Arg Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Gly Phe
                85                  90                  95      
Ile Trp Arg Arg Asp Val Gln Arg Val Tyr Val Glu Leu Lys Phe Thr
            100                 105                 110         
Val Arg Asp Cys Asn Ser Ile Pro Asn Ile Pro Gly Ser Cys Lys Glu
        115                 120                 125             
Thr Phe Asn Leu Phe Tyr Tyr Glu Ala Asp Ser Asp Val Ala Ser Ala
    130                 135                 140                 
Ser Ser Pro Phe Trp Met Glu Asn Pro Tyr Val Lys Val Asp Thr Ile
145                 150                 155                 160 
Ala Pro Asp Glu Ser Phe Ser Arg Leu Asp Ala Gly Arg Val Asn Thr
                165                 170                 175     
Lys Val Arg Ser Phe Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu Ala
            180                 185                 190         
Phe Gln Asp Gln Gly Ala Cys Met Ser Leu Ile Ser Val Arg Ala Phe
        195                 200                 205             
Tyr Lys Lys Cys Ala Ser Thr Thr Ala Gly Phe Ala Leu Phe Pro Glu
    210                 215                 220                 
Thr Leu Thr Gly Ala Glu Pro Thr Ser Leu Val Ile Ala Pro Gly Thr
225                 230                 235                 240 
Cys Ile Pro Asn Ala Val Glu Val Ser Val Pro Leu Lys Leu Tyr Cys
                245                 250                 255     
Asn Gly Asp Gly Glu Trp Met Val Pro Val Gly Ala Cys Thr Cys Ala
            260                 265                 270         
Thr Gly His Glu Pro Ala Ala Lys Glu Ser Gln Cys Arg Pro Cys Pro
        275                 280                 285             
Pro Gly Ser Tyr Lys Ala Lys Gln Gly Glu Gly Pro Cys Leu Pro Cys
    290                 295                 300                 
Pro Pro Asn Ser Arg Thr Thr Ser Pro Ala Ala Ser Ile Cys Thr Cys
305                 310                 315                 320 
His Asn Asn Phe Tyr Arg Ala Asp Ser Asp Ser Ala Asp Ser Ala Cys
                325                 330                 335     
Thr Thr Val Pro Ser Pro Pro Arg Gly Val Ile Ser Asn Val Asn Glu
            340                 345                 350         
Thr Ser Leu Ile Leu Glu Trp Ser Glu Pro Arg Asp Leu Gly Gly Arg
        355                 360                 365             
Asp Asp Leu Leu Tyr Asn Val Ile Cys Lys Lys Cys His Gly Ala Gly
    370                 375                 380                 
Gly Ala Ser Ala Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro
385                 390                 395                 400 
Arg Gln Leu Gly Leu Thr Glu Arg Arg Val His Ile Ser His Leu Leu
                405                 410                 415     
Ala His Thr Arg Tyr Thr Phe Glu Val Gln Ala Val Asn Gly Val Ser
            420                 425                 430         
Gly Lys Ser Pro Leu Pro Pro Arg Tyr Ala Ala Val Asn Ile Thr Thr
        435                 440                 445             
Asn Gln Ala Ala Pro Ser Glu Val Pro Thr Leu Arg Leu His Ser Ser
    450                 455                 460                 
Ser Gly Ser Ser Leu Thr Leu Ser Trp Ala Pro Pro Glu Arg Pro Asn
465                 470                 475                 480 
Gly Val Ile Leu Asp Tyr Glu Met Lys Tyr Phe Glu Lys Ser Glu Gly
                485                 490                 495     
Ile Ala Ser Thr Val Thr Ser Gln Met Asn Ser Val Gln Leu Asp Gly
            500                 505                 510         
Leu Arg Pro Asp Ala Arg Tyr Val Val Gln Val Arg Ala Arg Thr Val
        515                 520                 525             
Ala Gly Tyr Gly Gln Tyr Ser Arg Pro Ala Glu Phe Glu Thr Thr Ser
    530                 535                 540                 
Glu Arg Gly Ser Gly Ala Gln Gln Leu Gln Glu Gln Leu Pro Leu Ile
545                 550                 555                 560 
Val Gly Ser Ala Thr Ala Gly Leu Val Phe Val Val Ala Val Val Val
                565                 570                 575     
Ile Ala Ile Val Cys Leu Arg Lys Gln Arg His Gly Ser Asp Ser Glu
            580                 585                 590         
Tyr Thr Glu Lys Leu Gln Gln Tyr Ile Ala Pro Gly Met Lys Val Tyr
        595                 600                 605             
Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe
    610                 615                 620                 
Ala Lys Glu Ile Asp Val Ser Cys Val Lys Ile Glu Glu Val Ile Gly
625                 630                 635                 640 
Ala Gly Glu Phe Gly Glu Val Cys Arg Gly Arg Leu Lys Gln Pro Gly
                645                 650                 655     
Arg Arg Glu Val Phe Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr
            660                 665                 670         
Glu Arg Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met Gly Gln
        675                 680                 685             
Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Lys Ser
    690                 695                 700                 
Arg Pro Val Met Ile Leu Thr Glu Phe Met Glu Asn Cys Ala Leu Asp
705                 710                 715                 720 
Ser Phe Leu Arg Leu Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val
                725                 730                 735     
Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ser Glu Met
            740                 745                 750         
Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser
        755                 760                 765             
Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu
    770                 775                 780                 
Asp Asp Pro Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile
785                 790                 795                 800 
Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys Phe Thr
                805                 810                 815     
Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met
            820                 825                 830         
Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile
        835                 840                 845             
Asn Ala Val Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp Cys Pro
    850                 855                 860                 
Thr Ala Leu His Gln Leu Met Leu Asp Cys Trp Val Arg Asp Arg Asn
865                 870                 875                 880 
Leu Arg Pro Lys Phe Ser Gln Ile Val Asn Thr Leu Asp Lys Leu Ile
                885                 890                 895     
Arg Asn Ala Ala Ser Leu Lys Val Ile Ala Ser Ala Gln Ser Gly Met
            900                 905                 910         
Ser Gln Pro Leu Leu Asp Arg Thr Val Pro Asp Tyr Thr Thr Phe Thr
        915                 920                 925             
Thr Val Gly Asp Trp Leu Asp Ala Ile Lys Met Gly Arg Tyr Lys Glu
    930                 935                 940                 
Ser Phe Val Ser Ala Gly Phe Ala Ser Phe Asp Leu Val Ala Gln Met
945                 950                 955                 960 
Thr Ala Glu Asp Leu Leu Arg Ile Gly Val Thr Leu Ala Gly His Gln
                965                 970                 975     
Lys Lys Ile Leu Xaa Ser Ile Gln Asp Met Arg Leu Gln Met Asn Gln
            980                 985                 990         
Thr Leu Pro Val Gln Val
        995             


<210> 439
<211> 987
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 463
<223> Xaa = A or D

<220> 
<221> VARIANT        
<222> 471
<223> Xaa = Y or D

<220> 
<221> VARIANT        
<222> 926
<223> Xaa = E or D

<400> 439
Met Glu Leu Arg Val Leu Leu Cys Trp Ala Ser Leu Ala Ala Ala Leu
 1               5                  10                  15      
Glu Glu Thr Leu Leu Asn Thr Lys Leu Glu Thr Ala Asp Leu Lys Trp
            20                  25                  30          
Val Thr Phe Pro Gln Val Asp Gly Gln Trp Glu Glu Leu Ser Gly Leu
        35                  40                  45              
Asp Glu Glu Gln His Ser Val Arg Thr Tyr Glu Val Cys Asp Val Gln
    50                  55                  60                  
Arg Ala Pro Gly Gln Ala His Trp Leu Arg Thr Gly Trp Val Pro Arg
65                  70                  75                  80  
Arg Gly Ala Val His Val Tyr Ala Thr Leu Arg Phe Thr Met Leu Glu
                85                  90                  95      
Cys Leu Ser Leu Pro Arg Ala Gly Arg Ser Cys Lys Glu Thr Phe Thr
            100                 105                 110         
Val Phe Tyr Tyr Glu Ser Asp Ala Asp Thr Ala Thr Ala Leu Thr Pro
        115                 120                 125             
Ala Trp Met Glu Asn Pro Tyr Ile Lys Val Asp Thr Val Ala Ala Glu
    130                 135                 140                 
His Leu Thr Arg Lys Arg Pro Gly Ala Glu Ala Thr Gly Lys Val Asn
145                 150                 155                 160 
Val Lys Thr Leu Arg Leu Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu
                165                 170                 175     
Ala Phe Gln Asp Gln Gly Ala Cys Met Ala Leu Leu Ser Leu His Leu
            180                 185                 190         
Phe Tyr Lys Lys Cys Ala Gln Leu Thr Val Asn Leu Thr Arg Phe Pro
        195                 200                 205             
Glu Thr Val Pro Arg Glu Leu Val Val Pro Val Ala Gly Ser Cys Val
    210                 215                 220                 
Val Asp Ala Val Pro Ala Pro Gly Pro Ser Pro Ser Leu Tyr Cys Arg
225                 230                 235                 240 
Glu Asp Gly Gln Trp Ala Glu Gln Pro Val Thr Gly Cys Ser Cys Ala
                245                 250                 255     
Pro Gly Phe Glu Ala Ala Glu Gly Asn Thr Lys Cys Arg Ala Cys Ala
            260                 265                 270         
Gln Gly Thr Phe Lys Pro Leu Ser Gly Glu Gly Ser Cys Gln Pro Cys
        275                 280                 285             
Pro Ala Asn Ser His Ser Asn Thr Ile Gly Ser Ala Val Cys Gln Cys
    290                 295                 300                 
Arg Val Gly Tyr Phe Arg Ala Arg Thr Asp Pro Arg Gly Ala Pro Cys
305                 310                 315                 320 
Thr Thr Pro Pro Ser Ala Pro Arg Ser Val Val Ser Arg Leu Asn Gly
                325                 330                 335     
Ser Ser Leu His Leu Glu Trp Ser Ala Pro Leu Glu Ser Gly Gly Arg
            340                 345                 350         
Glu Asp Leu Thr Tyr Ala Leu Arg Cys Arg Glu Cys Arg Pro Gly Gly
        355                 360                 365             
Ser Cys Ala Pro Cys Gly Gly Asp Leu Thr Phe Asp Pro Gly Pro Arg
    370                 375                 380                 
Asp Leu Val Glu Pro Trp Val Val Val Arg Gly Leu Arg Pro Asp Phe
385                 390                 395                 400 
Thr Tyr Thr Phe Glu Val Thr Ala Leu Asn Gly Val Ser Ser Leu Ala
                405                 410                 415     
Thr Gly Pro Val Pro Phe Glu Pro Val Asn Val Thr Thr Asp Arg Glu
            420                 425                 430         
Val Pro Pro Ala Val Ser Asp Ile Arg Val Thr Arg Ser Ser Pro Ser
        435                 440                 445             
Ser Leu Ser Leu Ala Trp Ala Val Pro Arg Ala Pro Ser Gly Xaa Val
    450                 455                 460                 
Leu Asp Tyr Glu Val Lys Xaa His Glu Lys Gly Ala Glu Gly Pro Ser
465                 470                 475                 480 
Ser Val Arg Phe Leu Lys Thr Ser Glu Asn Arg Ala Glu Leu Arg Gly
                485                 490                 495     
Leu Lys Arg Gly Ala Ser Tyr Leu Val Gln Val Arg Ala Arg Ser Glu
            500                 505                 510         
Ala Gly Tyr Gly Pro Phe Gly Gln Glu His His Ser Gln Thr Gln Leu
        515                 520                 525             
Asp Glu Ser Glu Gly Trp Arg Glu Gln Leu Ala Leu Ile Ala Gly Thr
    530                 535                 540                 
Ala Val Val Gly Val Val Leu Val Leu Val Val Ile Val Val Ala Val
545                 550                 555                 560 
Leu Cys Leu Arg Lys Gln Ser Asn Gly Arg Glu Ala Glu Tyr Ser Asp
                565                 570                 575     
Lys His Gly Gln Tyr Leu Ile Gly His Gly Thr Lys Val Tyr Ile Asp
            580                 585                 590         
Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe Ala Lys
        595                 600                 605             
Glu Ile Asp Val Ser Tyr Val Lys Ile Glu Glu Val Ile Gly Ala Gly
    610                 615                 620                 
Glu Phe Gly Glu Val Cys Arg Gly Arg Leu Lys Ala Pro Gly Lys Lys
625                 630                 635                 640 
Glu Ser Cys Val Ala Ile Lys Thr Leu Lys Gly Gly Tyr Thr Glu Arg
                645                 650                 655     
Gln Arg Arg Glu Phe Leu Ser Glu Ala Ser Ile Met Gly Gln Phe Glu
            660                 665                 670         
His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Asn Ser Met Pro
        675                 680                 685             
Val Met Ile Leu Thr Glu Phe Met Glu Asn Gly Ala Leu Asp Ser Phe
    690                 695                 700                 
Leu Arg Leu Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met
705                 710                 715                 720 
Leu Arg Gly Ile Ala Ser Gly Met Arg Tyr Leu Ala Glu Met Ser Tyr
                725                 730                 735     
Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu
            740                 745                 750         
Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu Glu Asn
        755                 760                 765             
Ser Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile Pro Ile
    770                 775                 780                 
Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Lys Phe Thr Ser Ala
785                 790                 795                 800 
Ser Asp Ala Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Phe
                805                 810                 815     
Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Asn Ala
            820                 825                 830         
Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Pro Asp Cys Pro Thr Ser
        835                 840                 845             
Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp Arg Asn Ala Arg
    850                 855                 860                 
Pro Arg Phe Pro Gln Val Val Ser Ala Leu Asp Lys Met Ile Arg Asn
865                 870                 875                 880 
Pro Ala Ser Leu Lys Ile Val Ala Arg Glu Asn Gly Gly Ala Ser His
                885                 890                 895     
Pro Leu Leu Asp Gln Arg Gln Pro His Tyr Ser Ala Phe Gly Ser Val
            900                 905                 910         
Gly Glu Trp Leu Arg Ala Ile Lys Met Gly Arg Tyr Glu Xaa Ser Phe
        915                 920                 925             
Ala Ala Ala Gly Phe Gly Ser Phe Glu Leu Val Ser Gln Ile Ser Ala
    930                 935                 940                 
Glu Asp Leu Leu Arg Ile Gly Val Thr Leu Ala Gly His Gln Lys Lys
945                 950                 955                 960 
Ile Leu Ala Ser Val Gln His Met Lys Ser Gln Ala Lys Pro Gly Thr
                965                 970                 975     
Pro Gly Gly Thr Gly Gly Pro Ala Pro Gln Tyr
            980                 985         


<210> 440
<211> 1006
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 107
<223> Xaa = G or S

<220> 
<221> VARIANT        
<222> 267
<223> Xaa = P or R

<220> 
<221> VARIANT        
<222> 309
<223> Xaa = S or A

<220> 
<221> VARIANT        
<222> 484
<223> Xaa = R or Q

<400> 440
Met Val Cys Ser Leu Trp Val Leu Leu Leu Val Ser Ser Val Leu Ala
 1               5                  10                  15      
Leu Glu Glu Val Leu Leu Asp Thr Thr Gly Glu Thr Ser Glu Ile Gly
            20                  25                  30          
Trp Leu Thr Tyr Pro Pro Gly Gly Trp Asp Glu Val Ser Val Leu Asp
        35                  40                  45              
Asp Gln Arg Arg Leu Thr Arg Thr Phe Glu Ala Cys His Val Ala Gly
    50                  55                  60                  
Ala Pro Pro Gly Thr Gly Gln Asp Asn Trp Leu Gln Thr His Phe Val
65                  70                  75                  80  
Glu Arg Arg Gly Ala Gln Arg Ala His Ile Arg Leu His Phe Ser Val
                85                  90                  95      
Arg Ala Cys Ser Ser Leu Gly Val Ser Gly Xaa Thr Cys Arg Glu Thr
            100                 105                 110         
Phe Thr Leu Tyr Tyr Arg Gln Ala Glu Glu Pro Asp Ser Pro Asp Ser
        115                 120                 125             
Val Ser Ser Trp His Leu Lys Arg Trp Thr Lys Val Asp Thr Ile Ala
    130                 135                 140                 
Ala Asp Glu Ser Phe Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser
145                 150                 155                 160 
Ser Ala Ala Trp Ala Val Gly Pro His Gly Ala Gly Gln Arg Ala Gly
                165                 170                 175     
Leu Gln Leu Asn Val Lys Glu Arg Ser Phe Gly Pro Leu Thr Gln Arg
            180                 185                 190         
Gly Phe Tyr Val Ala Phe Gln Asp Thr Gly Ala Cys Leu Ala Leu Val
        195                 200                 205             
Ala Val Arg Leu Phe Ser Tyr Thr Cys Pro Ala Val Leu Arg Ser Phe
    210                 215                 220                 
Ala Ser Phe Pro Glu Thr Gln Ala Ser Gly Ala Gly Gly Ala Ser Leu
225                 230                 235                 240 
Val Ala Ala Val Gly Thr Cys Val Ala His Ala Glu Pro Glu Glu Asp
                245                 250                 255     
Gly Val Gly Gly Gln Ala Gly Gly Ser Pro Xaa Arg Leu His Cys Asn
            260                 265                 270         
Gly Glu Gly Lys Trp Met Val Ala Val Gly Gly Cys Arg Cys Gln Pro
        275                 280                 285             
Gly Tyr Gln Pro Ala Arg Gly Asp Lys Ala Cys Gln Ala Cys Pro Arg
    290                 295                 300                 
Gly Leu Tyr Lys Xaa Ser Ala Gly Asn Ala Pro Cys Ser Pro Cys Pro
305                 310                 315                 320 
Ala Arg Ser His Ala Pro Asn Pro Ala Ala Pro Val Cys Pro Cys Leu
                325                 330                 335     
Glu Gly Phe Tyr Arg Ala Ser Ser Asp Pro Pro Glu Ala Pro Cys Thr
            340                 345                 350         
Gly Pro Pro Ser Ala Pro Gln Glu Leu Trp Phe Glu Val Gln Gly Ser
        355                 360                 365             
Ala Leu Met Leu His Trp Arg Leu Pro Arg Glu Leu Gly Gly Arg Gly
    370                 375                 380                 
Asp Leu Leu Phe Asn Val Val Cys Lys Glu Cys Glu Gly Arg Gln Glu
385                 390                 395                 400 
Pro Ala Ser Gly Gly Gly Gly Thr Cys His Arg Cys Arg Asp Glu Val
                405                 410                 415     
His Phe Asp Pro Arg Gln Arg Gly Leu Thr Glu Ser Arg Val Leu Val
            420                 425                 430         
Gly Gly Leu Arg Ala His Val Pro Tyr Ile Leu Glu Val Gln Ala Val
        435                 440                 445             
Asn Gly Val Ser Glu Leu Ser Pro Asp Pro Pro Gln Ala Ala Ala Ile
    450                 455                 460                 
Asn Val Ser Thr Ser His Glu Val Pro Ser Ala Val Pro Val Val His
465                 470                 475                 480 
Gln Val Ser Xaa Ala Ser Asn Ser Ile Thr Val Ser Trp Pro Gln Pro
                485                 490                 495     
Asp Gln Thr Asn Gly Asn Ile Leu Asp Tyr Gln Leu Arg Tyr Tyr Asp
            500                 505                 510         
Gln Ala Glu Asp Glu Ser His Ser Phe Thr Leu Thr Ser Glu Thr Asn
        515                 520                 525             
Thr Ala Thr Val Thr Gln Leu Ser Pro Gly His Ile Tyr Gly Phe Gln
    530                 535                 540                 
Val Arg Ala Arg Thr Ala Ala Gly His Gly Pro Tyr Gly Gly Lys Val
545                 550                 555                 560 
Tyr Phe Gln Thr Leu Pro Gln Gly Glu Leu Ser Ser Gln Leu Pro Glu
                565                 570                 575     
Arg Leu Ser Leu Val Ile Gly Ser Ile Leu Gly Ala Leu Ala Phe Leu
            580                 585                 590         
Leu Leu Ala Ala Ile Thr Val Leu Ala Val Val Phe Gln Arg Lys Arg
        595                 600                 605             
Arg Gly Thr Gly Tyr Thr Glu Gln Leu Gln Gln Tyr Ser Ser Pro Gly
    610                 615                 620                 
Leu Gly Val Lys Tyr Tyr Ile Asp Pro Ser Thr Tyr Glu Asp Pro Cys
625                 630                 635                 640 
Gln Ala Ile Arg Glu Leu Ala Arg Glu Val Asp Pro Ala Tyr Ile Lys
                645                 650                 655     
Ile Glu Glu Val Ile Gly Thr Gly Ser Phe Gly Glu Val Arg Gln Gly
            660                 665                 670         
Arg Leu Gln Pro Arg Gly Arg Arg Glu Gln Thr Val Ala Ile Gln Ala
        675                 680                 685             
Leu Trp Ala Gly Gly Ala Glu Ser Leu Gln Met Thr Phe Leu Gly Arg
    690                 695                 700                 
Ala Ala Val Leu Gly Gln Phe Gln His Pro Asn Ile Leu Arg Leu Glu
705                 710                 715                 720 
Gly Val Val Thr Lys Ser Arg Pro Leu Met Val Leu Thr Glu Phe Met
                725                 730                 735     
Glu Leu Gly Pro Leu Asp Ser Phe Leu Arg Gln Arg Glu Gly Gln Phe
            740                 745                 750         
Ser Ser Leu Gln Leu Val Ala Met Gln Arg Gly Val Ala Ala Ala Met
        755                 760                 765             
Gln Tyr Leu Ser Ser Phe Ala Phe Val His Arg Ser Leu Ser Ala His
    770                 775                 780                 
Ser Val Leu Val Asn Ser His Leu Val Cys Lys Val Ala Arg Leu Gly
785                 790                 795                 800 
His Ser Pro Gln Gly Pro Ser Cys Leu Leu Arg Trp Ala Ala Pro Glu
                805                 810                 815     
Val Ile Ala His Gly Lys His Thr Thr Ser Ser Asp Val Trp Ser Phe
            820                 825                 830         
Gly Ile Leu Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp
        835                 840                 845             
Asp Met Ser Glu Gln Glu Val Leu Asn Ala Ile Glu Gln Glu Phe Arg
    850                 855                 860                 
Leu Pro Pro Pro Pro Gly Cys Pro Pro Gly Leu His Leu Leu Met Leu
865                 870                 875                 880 
Asp Thr Trp Gln Lys Asp Arg Ala Arg Arg Pro His Phe Asp Gln Leu
                885                 890                 895     
Val Ala Ala Phe Asp Lys Met Ile Arg Lys Pro Asp Thr Leu Gln Ala
            900                 905                 910         
Gly Gly Asp Pro Gly Glu Arg Pro Ser Gln Ala Leu Leu Thr Pro Val
        915                 920                 925             
Ala Leu Asp Phe Pro Cys Leu Asp Ser Pro Gln Ala Trp Leu Ser Ala
    930                 935                 940                 
Ile Gly Leu Glu Cys Tyr Gln Asp Asn Phe Ser Lys Phe Gly Leu Cys
945                 950                 955                 960 
Thr Phe Ser Asp Val Ala Gln Leu Ser Leu Glu Asp Leu Pro Ala Leu
                965                 970                 975     
Gly Ile Thr Leu Ala Gly His Gln Lys Lys Leu Leu His His Ile Gln
            980                 985                 990         
Leu Leu Gln Gln His Leu Arg Gln Gln Gly Ser Val Glu Val
        995                 1000                1005    

<210> 441
<211> 1210
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 521
<223> Xaa = R or K

<400> 441
Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala
 1               5                  10                  15      
Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln
            20                  25                  30          
Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe
        35                  40                  45              
Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn
    50                  55                  60                  
Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys
65                  70                  75                  80  
Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val
                85                  90                  95      
Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr
            100                 105                 110         
Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn
        115                 120                 125             
Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu
    130                 135                 140                 
His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu
145                 150                 155                 160 
Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met
                165                 170                 175     
Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro
            180                 185                 190         
Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln
        195                 200                 205             
Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg
    210                 215                 220                 
Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys
225                 230                 235                 240 
Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp
                245                 250                 255     
Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro
            260                 265                 270         
Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly
        275                 280                 285             
Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His
    290                 295                 300                 
Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu
305                 310                 315                 320 
Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val
                325                 330                 335     
Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn
            340                 345                 350         
Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp
        355                 360                 365             
Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr
    370                 375                 380                 
Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu
385                 390                 395                 400 
Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp
                405                 410                 415     
Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln
            420                 425                 430         
His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu
        435                 440                 445             
Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser
    450                 455                 460                 
Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu
465                 470                 475                 480 
Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu
                485                 490                 495     
Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro
            500                 505                 510         
Glu Gly Cys Trp Gly Pro Glu Pro Xaa Asp Cys Val Ser Cys Arg Asn
        515                 520                 525             
Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly
    530                 535                 540                 
Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro
545                 550                 555                 560 
Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro
                565                 570                 575     
Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val
            580                 585                 590         
Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp
        595                 600                 605             
Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys
    610                 615                 620                 
Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly
625                 630                 635                 640 
Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu
                645                 650                 655     
Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His
            660                 665                 670         
Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu
        675                 680                 685             
Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu
    690                 695                 700                 
Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser
705                 710                 715                 720 
Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu
                725                 730                 735     
Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser
            740                 745                 750         
Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser
        755                 760                 765             
Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser
    770                 775                 780                 
Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp
785                 790                 795                 800 
Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn
                805                 810                 815     
Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg
            820                 825                 830         
Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro
        835                 840                 845             
Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala
    850                 855                 860                 
Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp
865                 870                 875                 880 
Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp
                885                 890                 895     
Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser
            900                 905                 910         
Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu
        915                 920                 925             
Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr
    930                 935                 940                 
Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys
945                 950                 955                 960 
Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln
                965                 970                 975     
Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro
            980                 985                 990         
Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met Asp
        995                 1000                1005            
Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe
    1010                1015                1020                
Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser Ala
1025                1030                1035                1040
Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu Gln
                1045                1050                1055    
Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg Tyr Ser Ser Asp
            1060                1065                1070        
Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp Asp Thr Phe Leu Pro
        1075                1080                1085            
Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly Ser
    1090                1095                1100                
Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro Ser
1105                1110                1115                1120
Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala Val Gly Asn Pro
                1125                1130                1135    
Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn Ser Thr Phe Asp
            1140                1145                1150        
Ser Pro Ala His Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu Asp
        1155                1160                1165            
Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn
    1170                1175                1180                
Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val
1185                1190                1195                1200
Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala
                1205                1210

<210> 442
<211> 1255
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 452
<223> Xaa = W or C

<220> 
<221> VARIANT        
<222> 654
<223> Xaa = I or V 

<220> 
<221> VARIANT        
<222> 655
<223> Xaa = I or V

<220> 
<221> VARIANT        
<222> 1170
<223> Xaa = P or A 

<400> 442
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu
            340                 345                 350         
Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys
        355                 360                 365             
Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp
    370                 375                 380                 
Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe
385                 390                 395                 400 
Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro
                405                 410                 415     
Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg
            420                 425                 430         
Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu
        435                 440                 445             
Gly Ile Ser Xaa Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly
    450                 455                 460                 
Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val
465                 470                 475                 480 
Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr
                485                 490                 495     
Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His
            500                 505                 510         
Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys
        515                 520                 525             
Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys
    530                 535                 540                 
Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys
545                 550                 555                 560 
Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys
                565                 570                 575     
Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp
            580                 585                 590         
Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu
        595                 600                 605             
Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln
    610                 615                 620                 
Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys
625                 630                 635                 640 
Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Xaa Xaa Ser
                645                 650                 655     
Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly
            660                 665                 670         
Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg
        675                 680                 685             
Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly
    690                 695                 700                 
Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu
705                 710                 715                 720 
Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys
                725                 730                 735     
Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile
            740                 745                 750         
Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu
        755                 760                 765             
Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg
    770                 775                 780                 
Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu
785                 790                 795                 800 
Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg
                805                 810                 815     
Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly
            820                 825                 830         
Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala
        835                 840                 845             
Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe
    850                 855                 860                 
Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp
865                 870                 875                 880 
Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg
                885                 890                 895     
Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val
            900                 905                 910         
Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala
        915                 920                 925             
Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro
    930                 935                 940                 
Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met
945                 950                 955                 960 
Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe
                965                 970                 975     
Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu
            980                 985                 990         
Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu
        995                 1000                1005            
Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr Leu
    1010                1015                1020                
Val Pro Gln Gln Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly Ala Gly
1025                1030                1035                1040
Gly Met Val His His Arg His Arg Ser Ser Ser Thr Arg Ser Gly Gly
                1045                1050                1055    
Gly Asp Leu Thr Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala Pro Arg
            1060                1065                1070        
Ser Pro Leu Ala Pro Ser Glu Gly Ala Gly Ser Asp Val Phe Asp Gly
        1075                1080                1085            
Asp Leu Gly Met Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro Thr His
    1090                1095                1100                
Asp Pro Ser Pro Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val Pro Leu
1105                1110                1115                1120
Pro Ser Glu Thr Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser Pro Gln
                1125                1130                1135    
Pro Glu Tyr Val Asn Gln Pro Asp Val Arg Pro Gln Pro Pro Ser Pro
            1140                1145                1150        
Arg Glu Gly Pro Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu
        1155                1160                1165            
Arg Xaa Lys Thr Leu Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val
    1170                1175                1180                
Phe Ala Phe Gly Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln
1185                1190                1195                1200
Gly Gly Ala Ala Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala
                1205                1210                1215    
Phe Asp Asn Leu Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala
            1220                1225                1230        
Pro Pro Ser Thr Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr
        1235                1240                1245            
Leu Gly Leu Asp Val Pro Val
    1250                1255


<210> 443
<211> 820
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 22
<223> Xaa = R or S

<220> 
<221> VARIANT        
<222> 97, 198
<223> Xaa = G or D

<220> 
<221> VARIANT        
<222> 99, 275
<223> Xaa = Y or C

<220> 
<221> VARIANT        
<222> 165
<223> Xaa = A or S

<220> 
<221> VARIANT        
<222> 190
<223> Xaa = K or E

<220> 
<221> VARIANT        
<222> 192
<223> Xaa = S or G

<220> 
<221> VARIANT        
<222> 250
<223> Xaa = P or R

<220> 
<221> VARIANT        
<222> 605
<223> Xaa = V or M

<220> 
<221> VARIANT        
<222> 664
<223> Xaa = W or R

<220> 
<221> VARIANT        
<222> 717
<223> Xaa = M or R

<220> 
<221> VARIANT        
<222> 770
<223> Xaa = P or S

<220> 
<221> VARIANT        
<222> 816
<223> Xaa = G or R

<220> 
<221> VARIANT        
<222> 820
<223> Xaa = R or C

<400> 443
Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala
 1               5                  10                  15      
Thr Leu Cys Thr Ala Xaa Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln
            20                  25                  30          
Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly
        35                  40                  45              
Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile
    50                  55                  60                  
Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg
65                  70                  75                  80  
Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser
                85                  90                  95      
Xaa Leu Xaa Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr
            100                 105                 110         
Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp
        115                 120                 125             
Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr
    130                 135                 140                 
Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu
145                 150                 155                 160 
Lys Lys Leu His Xaa Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys
                165                 170                 175     
Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Xaa Asn Xaa
            180                 185                 190         
Lys Glu Phe Lys Pro Xaa His Arg Ile Gly Gly Tyr Lys Val Arg Tyr
        195                 200                 205             
Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp Lys Gly
    210                 215                 220                 
Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr
225                 230                 235                 240 
Tyr Gln Leu Asp Val Val Glu Arg Ser Xaa His Arg Pro Ile Leu Gln
                245                 250                 255     
Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn Val Glu
            260                 265                 270         
Phe Met Xaa Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln Trp Leu
        275                 280                 285             
Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro
    290                 295                 300                 
Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp Lys Glu
305                 310                 315                 320 
Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala Gly Glu
                325                 330                 335     
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His Ser Ala
            340                 345                 350         
Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val Met Thr
        355                 360                 365             
Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala Phe Leu
    370                 375                 380                 
Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys Ser Gly
385                 390                 395                 400 
Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys Leu Ala
                405                 410                 415     
Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp Ser Ser
            420                 425                 430         
Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser
        435                 440                 445             
Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro
    450                 455                 460                 
Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys
465                 470                 475                 480 
Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile
                485                 490                 495     
Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala Val Lys
            500                 505                 510         
Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser
        515                 520                 525             
Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn
    530                 535                 540                 
Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu
545                 550                 555                 560 
Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro
                565                 570                 575     
Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu Glu Gln
            580                 585                 590         
Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Xaa Ala Arg Gly
        595                 600                 605             
Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala
    610                 615                 620                 
Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe
625                 630                 635                 640 
Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr
                645                 650                 655     
Asn Gly Arg Leu Pro Val Lys Xaa Met Ala Pro Glu Ala Leu Phe Asp
            660                 665                 670         
Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
        675                 680                 685             
Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val
    690                 695                 700                 
Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Xaa Asp Lys Pro
705                 710                 715                 720 
Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His
                725                 730                 735     
Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu
            740                 745                 750         
Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser
        755                 760                 765             
Met Xaa Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser
    770                 775                 780                 
Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro
785                 790                 795                 800 
Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn Gly Xaa
                805                 810                 815     
Leu Lys Arg Xaa
            820 


<210> 444
<211> 821
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = R or P

<220> 
<221> VARIANT        
<222> 20
<223> Xaa = W or C

<220> 
<221> VARIANT        
<222> 31
<223> Xaa = T or I

<220> 
<221> VARIANT        
<222> 105
<223> Xaa = Y or C

<220> 
<221> VARIANT        
<222> 152, 338, 384, 678
<223> Xaa = R or G

<220> 
<221> VARIANT        
<222> 162, 186
<223> Xaa = M or T

<220> 
<221> VARIANT        
<222> 172
<223> Xaa = A or F

<220> 
<221> VARIANT        
<222> 252
<223> Xaa = S or W or L

<220> 
<221> VARIANT        
<222> 253
<223> Xaa = P or S or F

<220> 
<221> VARIANT        
<222> 267
<223> Xaa = S or P

<220> 
<221> VARIANT        
<222> 276
<223> Xaa = F or V

<220> 
<221> VARIANT        
<222> 278
<223> Xaa = C or F

<220> 
<221> VARIANT        
<222> 281
<223> Xaa = Y or C

<220> 
<221> VARIANT        
<222> 289
<223> Xaa = Q or P

<220> 
<221> VARIANT        
<222> 315
<223> Xaa = A or S

<220> 
<221> VARIANT        
<222> 340
<223> Xaa = Y or H

<220> 
<221> VARIANT        
<222> 341
<223> Xaa = T or P

<220> 
<221> VARIANT        
<222> 342
<223> Xaa = C or R or Y or S or F or W

<220> 
<221> VARIANT        
<222> 344
<223> Xaa = A or P or G

<220> 
<221> VARIANT        
<222> 347, 351, 372
<223> Xaa = S or C

<220> 
<221> VARIANT        
<222> 443
<223> Xaa = P or A

<220> 
<221> VARIANT        
<222> 549
<223> Xaa = N or H

<220> 
<221> VARIANT        
<222> 565
<223> Xaa = E or G

<220> 
<221> VARIANT        
<222> 641
<223> Xaa = K or R

<220> 
<221> VARIANT        
<222> 659
<223> Xaa = K or N

<220> 
<221> VARIANT        
<222> 663
<223> Xaa = G or E

<400> 444
Met Val Ser Trp Gly Xaa Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Xaa Thr
            20                  25                  30          
Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu
        35                  40                  45              
Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu
    50                  55                  60                  
Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly
65                  70                  75                  80  
Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly
                85                  90                  95      
Ala Thr Pro Arg Asp Ser Gly Leu Xaa Ala Cys Thr Ala Ser Arg Thr
            100                 105                 110         
Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile
        115                 120                 125             
Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val
    130                 135                 140                 
Ser Glu Asn Ser Asn Asn Lys Xaa Ala Pro Tyr Trp Thr Asn Thr Glu
145                 150                 155                 160 
Lys Xaa Glu Lys Arg Leu His Ala Val Pro Ala Xaa Asn Thr Val Lys
                165                 170                 175     
Phe Arg Cys Pro Ala Gly Gly Asn Pro Xaa Pro Thr Met Arg Trp Leu
            180                 185                 190         
Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys
        195                 200                 205             
Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser
    210                 215                 220                 
Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile
225                 230                 235                 240 
Asn His Thr Tyr His Leu Asp Val Val Glu Arg Xaa Xaa His Arg Pro
                245                 250                 255     
Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Xaa Thr Val Val Gly Gly
            260                 265                 270         
Asp Val Glu Xaa Val Xaa Lys Val Xaa Ser Asp Ala Gln Pro His Ile
        275                 280                 285             
Xaa Xaa Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp
    290                 295                 300                 
Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Xaa Gly Val Asn Thr Thr
305                 310                 315                 320 
Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp
                325                 330                 335     
Ala Xaa Glu Xaa Xaa Xaa Leu Xaa Gly Asn Xaa Ile Gly Ile Xaa Phe
            340                 345                 350         
His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu
        355                 360                 365             
Ile Thr Ala Xaa Pro Asp Xaa Leu Glu Ile Ala Ile Tyr Cys Ile Xaa
    370                 375                 380                 
Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met
385                 390                 395                 400 
Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His
                405                 410                 415     
Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala
            420                 425                 430         
Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Xaa Leu Val Arg Ile Thr
        435                 440                 445             
Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser
    450                 455                 460                 
Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys
465                 470                 475                 480 
Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val
                485                 490                 495     
Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val
            500                 505                 510         
Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu
        515                 520                 525             
Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His
    530                 535                 540                 
Lys Asn Ile Ile Xaa Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu
545                 550                 555                 560 
Tyr Val Ile Val Xaa Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu
                565                 570                 575     
Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg
            580                 585                 590         
Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr
        595                 600                 605             
Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His
    610                 615                 620                 
Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met
625                 630                 635                 640 
Xaa Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr
                645                 650                 655     
Tyr Lys Xaa Thr Thr Asn Xaa Arg Leu Pro Val Lys Trp Met Ala Pro
            660                 665                 670         
Glu Ala Leu Phe Asp Xaa Val Tyr Thr His Gln Ser Asp Val Trp Ser
        675                 680                 685             
Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr
    690                 695                 700                 
Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His
705                 710                 715                 720 
Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met
                725                 730                 735     
Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln
            740                 745                 750         
Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu
        755                 760                 765             
Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro
    770                 775                 780                 
Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro
785                 790                 795                 800 
Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn
                805                 810                 815     
Gly Ser Val Lys Thr
            820     


<210> 445
<211> 806
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 65
<223> Xaa = G or R

<220> 
<221> VARIANT        
<222> 250
<223> Xaa = P or R

<220> 
<221> VARIANT        
<222> 383
<223> Xaa = F or C

<400> 445
Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile
 1               5                  10                  15      
Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val
            20                  25                  30          
Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln
        35                  40                  45              
Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro
    50                  55                  60                  
Xaa Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly
65                  70                  75                  80  
Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val
                85                  90                  95      
Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg
            100                 105                 110         
Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala
        115                 120                 125             
Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr
    130                 135                 140                 
Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp
145                 150                 155                 160 
Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys
                165                 170                 175     
Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly
            180                 185                 190         
Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His
        195                 200                 205             
Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly
    210                 215                 220                 
Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr
225                 230                 235                 240 
Tyr Thr Leu Asp Val Leu Glu Arg Ser Xaa His Arg Pro Ile Leu Gln
                245                 250                 255     
Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu
            260                 265                 270         
Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu
        275                 280                 285             
Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro
    290                 295                 300                 
Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu
305                 310                 315                 320 
Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu
                325                 330                 335     
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala
            340                 345                 350         
Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu
        355                 360                 365             
Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Xaa Phe
    370                 375                 380                 
Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser
385                 390                 395                 400 
Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg
                405                 410                 415     
Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser Met Ser
            420                 425                 430         
Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly
        435                 440                 445             
Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys
    450                 455                 460                 
Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu
465                 470                 475                 480 
Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys
                485                 490                 495     
Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp
            500                 505                 510         
Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met
        515                 520                 525             
Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala
    530                 535                 540                 
Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys
545                 550                 555                 560 
Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp
                565                 570                 575     
Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys
            580                 585                 590         
Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu
        595                 600                 605             
Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu
    610                 615                 620                 
Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg
625                 630                 635                 640 
Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu
                645                 650                 655     
Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr
            660                 665                 670         
His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe
        675                 680                 685             
Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe
    690                 695                 700                 
Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr
705                 710                 715                 720 
His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser
                725                 730                 735     
Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu
            740                 745                 750         
Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu
        755                 760                 765             
Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly
    770                 775                 780                 
Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser
785                 790                 795                 800 
Ser Gly Gly Ser Arg Thr
                805     


<210> 446
<211> 802
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = V or I

<220> 
<221> VARIANT        
<222> 136
<223> Xaa = P or L

<220> 
<221> VARIANT        
<222> 275
<223> Xaa = S or R

<220> 
<221> VARIANT        
<222> 297
<223> Xaa = D or V

<220> 
<221> VARIANT        
<222> 388
<223> Xaa = G or R

<220> 
<221> VARIANT        
<222> 616
<223> Xaa = R or L

<400> 446
Met Arg Leu Leu Leu Ala Leu Leu Gly Xaa Leu Leu Ser Val Pro Gly
 1               5                  10                  15      
Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro
            20                  25                  30          
Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala
        35                  40                  45              
Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly
    50                  55                  60                  
His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg
65                  70                  75                  80  
Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala
                85                  90                  95      
Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn
            100                 105                 110         
Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu
        115                 120                 125             
Asp Pro Lys Ser His Arg Asp Xaa Ser Asn Arg His Ser Tyr Pro Gln
    130                 135                 140                 
Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His
145                 150                 155                 160 
Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly
                165                 170                 175     
Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His
            180                 185                 190         
Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser
        195                 200                 205             
Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys
    210                 215                 220                 
Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp
225                 230                 235                 240 
Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro
                245                 250                 255     
Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys
            260                 265                 270         
Val Tyr Xaa Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val
        275                 280                 285             
Ile Asn Gly Ser Ser Phe Gly Ala Xaa Gly Phe Pro Tyr Val Gln Val
    290                 295                 300                 
Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu
305                 310                 315                 320 
Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly
                325                 330                 335     
Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro
            340                 345                 350         
Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr
        355                 360                 365             
Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu
    370                 375                 380                 
Leu Leu Ala Xaa Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro
385                 390                 395                 400 
Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg
                405                 410                 415     
Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu
            420                 425                 430         
Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly
        435                 440                 445             
Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg
    450                 455                 460                 
Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln
465                 470                 475                 480 
Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln
                485                 490                 495     
Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys
            500                 505                 510         
Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly
        515                 520                 525             
Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly
    530                 535                 540                 
Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu
545                 550                 555                 560 
Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly
                565                 570                 575     
Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys
            580                 585                 590         
Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys
        595                 600                 605             
Ile His Arg Asp Leu Ala Ala Xaa Asn Val Leu Val Thr Glu Asp Asn
    610                 615                 620                 
Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile
625                 630                 635                 640 
Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met
                645                 650                 655     
Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val
            660                 665                 670         
Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser
        675                 680                 685             
Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu
    690                 695                 700                 
Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly
705                 710                 715                 720 
Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe
                725                 730                 735     
Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu
            740                 745                 750         
Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly
        755                 760                 765             
Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His
    770                 775                 780                 
Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val
785                 790                 795                 800 
Gln Thr
        

<210> 447
<211> 1390
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 37, 145, 158, 237
<223> Xaa = V or A

<220> 
<221> VARIANT        
<222> 39, 1250
<223> Xaa = M or T

<220> 
<221> VARIANT        
<222> 42
<223> Xaa = Q or R

<220> 
<221> VARIANT        
<222> 113, 508
<223> Xaa = K or R

<220> 
<221> VARIANT        
<222> 114, 382
<223> Xaa = D or N

<220> 
<221> VARIANT        
<222> 148, 476, 1094
<223> Xaa = H or R

<220> 
<221> VARIANT        
<222> 151
<223> Xaa = T or P

<220> 
<221> VARIANT        
<222> 168
<223> Xaa = E or D

<220> 
<221> VARIANT        
<222> 193
<223> Xaa = I or T

<220> 
<221> VARIANT        
<222> 216
<223> Xaa = V or L

<220> 
<221> VARIANT        
<222> 276, 511, 729
<223> Xaa = T or A

<220> 
<221> VARIANT        
<222> 314
<223> Xaa = F or L

<220> 
<221> VARIANT        
<222> 337
<223> Xaa = L or P

<220> 
<221> VARIANT        
<222> 340
<223> Xaa = D or V

<220> 
<221> VARIANT        
<222> 400
<223> Xaa = R or G

<220> 
<221> VARIANT        
<222> 481
<223> Xaa = L or M

<220> 
<221> VARIANT        
<222> 500
<223> Xaa = D or G

<220> 
<221> VARIANT        
<222> 501, 542
<223> Xaa = Y or H

<220> 
<221> VARIANT        
<222> 622
<223> Xaa = L or S

<220> 
<221> VARIANT        
<222> 720
<223> Xaa = F or S

<220> 
<221> VARIANT        
<222> 1100
<223> Xaa = N or Y

<220> 
<221> VARIANT        
<222> 1230
<223> Xaa = C or Y

<220> 
<221> VARIANT        
<222> 1235
<223> Xaa = Y or D

<400> 447
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Xaa Asn Xaa Lys Tyr Xaa Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Xaa Xaa Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Xaa Phe Pro Xaa Asn His Xaa Ala Asp Ile Gln Ser Glu Xaa His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Xaa Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Xaa Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Xaa Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Xaa Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Xaa Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Xaa Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Xaa Asn Asp Xaa Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Xaa Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Xaa
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro Xaa Val Asn Phe Leu
465                 470                 475                 480 
Xaa Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Xaa Xaa Thr Leu Val Ile Thr Gly Xaa Lys Ile Xaa Lys
            500                 505                 510         
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525             
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys Xaa Asp Lys
    530                 535                 540                 
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560 
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575     
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590         
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605             
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Xaa Lys Cys
    610                 615                 620                 
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640 
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
                645                 650                 655     
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly
            660                 665                 670         
Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg
        675                 680                 685             
His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn
    690                 695                 700                 
Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Xaa
705                 710                 715                 720 
Ala Val Lys Leu Lys Ile Asp Leu Xaa Asn Arg Glu Thr Ser Ile Phe
                725                 730                 735     
Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser
            740                 745                 750         
Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn
        755                 760                 765             
Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg
    770                 775                 780                 
Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys
785                 790                 795                 800 
Cys Xaa Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys
                805                 810                 815     
Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp
            820                 825                 830         
Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val
        835                 840                 845             
Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp
    850                 855                 860                 
Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys
865                 870                 875                 880 
Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val
                885                 890                 895     
Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys
            900                 905                 910         
Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp
        915                 920                 925             
Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala
    930                 935                 940                 
Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln
945                 950                 955                 960 
Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His
                965                 970                 975     
Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr
            980                 985                 990         
Thr Glu Met Val Ser Asn Glu Ser Val Asp Tyr Arg Ala Thr Phe Pro
        995                 1000                1005            
Glu Asp Gln Phe Pro Asn Ser Ser Gln Asn Gly Ser Cys Arg Gln Val
    1010                1015                1020                
Gln Tyr Pro Leu Thr Asp Met Ser Pro Ile Leu Thr Ser Gly Asp Ser
1025                1030                1035                1040
Asp Ile Ser Ser Pro Leu Leu Gln Asn Thr Val His Ile Asp Leu Ser
                1045                1050                1055    
Ala Leu Asn Pro Glu Leu Val Gln Ala Val Gln His Val Val Ile Gly
            1060                1065                1070        
Pro Ser Ser Leu Ile Val His Phe Asn Glu Val Ile Gly Arg Gly His
        1075                1080                1085            
Phe Gly Cys Val Tyr Xaa Gly Thr Leu Leu Asp Xaa Asp Gly Lys Lys
    1090                1095                1100                
Ile His Cys Ala Val Lys Ser Leu Asn Arg Ile Thr Asp Ile Gly Glu
1105                1110                1115                1120
Val Ser Gln Phe Leu Thr Glu Gly Ile Ile Met Lys Asp Phe Ser His
                1125                1130                1135    
Pro Asn Val Leu Ser Leu Leu Gly Ile Cys Leu Arg Ser Glu Gly Ser
            1140                1145                1150        
Pro Leu Val Val Leu Pro Tyr Met Lys His Gly Asp Leu Arg Asn Phe
        1155                1160                1165            
Ile Arg Asn Glu Thr His Asn Pro Thr Val Lys Asp Leu Ile Gly Phe
    1170                1175                1180                
Gly Leu Gln Val Ala Lys Gly Met Lys Tyr Leu Ala Ser Lys Lys Phe
1185                1190                1195                1200
Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asp Glu Lys Phe
                1205                1210                1215    
Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Asp Met Xaa Asp Lys
            1220                1225                1230        
Glu Tyr Xaa Ser Val His Asn Lys Thr Gly Ala Lys Leu Pro Val Lys
        1235                1240                1245            
Trp Xaa Ala Leu Glu Ser Leu Gln Thr Gln Lys Phe Thr Thr Lys Ser
    1250                1255                1260                
Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Leu Met Thr Arg Gly
1265                1270                1275                1280
Ala Pro Pro Tyr Pro Asp Val Asn Thr Phe Asp Ile Thr Val Tyr Leu
                1285                1290                1295    
Leu Gln Gly Arg Arg Leu Leu Gln Pro Glu Tyr Cys Pro Asp Pro Leu
            1300                1305                1310        
Tyr Glu Val Met Leu Lys Cys Trp His Pro Lys Ala Glu Met Arg Pro
        1315                1320                1325            
Ser Phe Ser Glu Leu Val Ser Arg Ile Ser Ala Ile Phe Ser Thr Phe
    1330                1335                1340                
Ile Gly Glu His Tyr Val His Val Asn Ala Thr Tyr Val Asn Val Lys
1345                1350                1355                1360
Cys Val Ala Pro Tyr Pro Ser Leu Leu Ser Ser Glu Asp Asn Ala Asp
                1365                1370                1375    
Asp Glu Val Asp Thr Arg Pro Ala Ser Phe Trp Glu Thr Ser
            1380                1385                1390

<210> 448
<211> 1400
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 113, 1195
<223> Xaa = G or S

<220> 
<221> VARIANT        
<222> 209
<223> Xaa = G or A

<220> 
<221> VARIANT        
<222> 322, 523
<223> Xaa = Q or R

<220> 
<221> VARIANT        
<222> 440
<223> Xaa = N or S

<220> 
<221> VARIANT        
<222> 946
<223> Xaa = V or M

<220> 
<221> VARIANT        
<222> 1232
<223> Xaa = R or G or D or V

<220> 
<221> VARIANT        
<222> 1254
<223> Xaa = M or T

<220> 
<221> VARIANT        
<222> 1335
<223> Xaa = R or G

<400> 448
Met Glu Leu Leu Pro Pro Leu Pro Gln Ser Phe Leu Leu Leu Leu Leu
 1               5                  10                  15      
Leu Pro Ala Lys Pro Ala Ala Gly Glu Asp Trp Gln Cys Pro Arg Thr
            20                  25                  30          
Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val Lys Tyr Val Val Pro Ser
        35                  40                  45              
Phe Ser Ala Gly Gly Leu Val Gln Ala Met Val Thr Tyr Glu Gly Asp
    50                  55                  60                  
Arg Asn Glu Ser Ala Val Phe Val Ala Ile Arg Asn Arg Leu His Val
65                  70                  75                  80  
Leu Gly Pro Asp Leu Lys Ser Val Gln Ser Leu Ala Thr Gly Pro Ala
                85                  90                  95      
Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala Cys Gly Pro Gly Pro His
            100                 105                 110         
Xaa Pro Pro Gly Asp Thr Asp Thr Lys Val Leu Val Leu Asp Pro Ala
        115                 120                 125             
Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe
    130                 135                 140                 
Leu His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro
145                 150                 155                 160 
Ala Cys Leu Phe Ser Ala His His Asn Arg Pro Asp Asp Cys Pro Asp
                165                 170                 175     
Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln Gly
            180                 185                 190         
Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Ala Ala Val Ala
        195                 200                 205             
Xaa Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ala Asp
    210                 215                 220                 
Ala Ser Gly Phe Ala Pro Gly Phe Val Ala Leu Ser Val Leu Pro Lys
225                 230                 235                 240 
His Leu Val Ser Tyr Ser Ile Glu Tyr Val His Ser Phe His Thr Gly
                245                 250                 255     
Ala Phe Val Tyr Phe Leu Thr Val Gln Pro Ala Ser Val Thr Asp Asp
            260                 265                 270         
Pro Ser Ala Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro
        275                 280                 285             
Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys Arg Phe Ala Pro
    290                 295                 300                 
Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Gly Gln Pro Tyr Pro Val
305                 310                 315                 320 
Leu Xaa Val Ala His Ser Ala Pro Val Gly Ala Gln Leu Ala Thr Glu
                325                 330                 335     
Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val Thr
            340                 345                 350         
Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn Ser Val Val Cys Ala
        355                 360                 365             
Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp Glu Gly Val Glu Arg
    370                 375                 380                 
Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg Arg Gly Leu Asp Phe
385                 390                 395                 400 
Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Pro Gly Leu Glu Ala Leu
                405                 410                 415     
Ser Pro Asn Thr Ser Cys Arg His Phe Pro Leu Leu Val Ser Ser Ser
            420                 425                 430         
Phe Ser Arg Val Asp Leu Phe Xaa Gly Leu Leu Gly Pro Val Gln Val
        435                 440                 445             
Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn Val Thr Val Ala His Met
    450                 455                 460                 
Gly Thr Met Asp Gly Arg Ile Leu Gln Val Glu Leu Val Arg Ser Leu
465                 470                 475                 480 
Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Asp Ser Gly Gln
                485                 490                 495     
Pro Val Gln Arg Asp Val Ser Arg Leu Gly Asp His Leu Leu Phe Ala
            500                 505                 510         
Ser Gly Asp Gln Val Phe Gln Val Pro Ile Xaa Gly Pro Gly Cys Arg
        515                 520                 525             
His Phe Leu Thr Cys Gly Arg Cys Leu Arg Ala Trp His Phe Met Gly
    530                 535                 540                 
Cys Gly Trp Cys Gly Asn Met Cys Gly Gln Gln Lys Glu Cys Pro Gly
545                 550                 555                 560 
Ser Trp Gln Gln Asp His Cys Pro Pro Lys Leu Thr Glu Phe His Pro
                565                 570                 575     
His Ser Gly Pro Leu Arg Gly Ser Thr Arg Leu Thr Leu Cys Gly Ser
            580                 585                 590         
Asn Phe Tyr Leu His Pro Ser Gly Leu Val Pro Glu Gly Thr His Gln
        595                 600                 605             
Val Thr Val Gly Gln Ser Pro Cys Arg Pro Leu Pro Lys Asp Ser Ser
    610                 615                 620                 
Lys Leu Arg Pro Val Pro Arg Lys Asp Phe Val Glu Glu Phe Glu Cys
625                 630                 635                 640 
Glu Leu Glu Pro Leu Gly Thr Gln Ala Val Gly Pro Thr Asn Val Ser
                645                 650                 655     
Leu Thr Val Thr Asn Met Pro Pro Gly Lys His Phe Arg Val Asp Gly
            660                 665                 670         
Thr Ser Val Leu Arg Gly Phe Ser Phe Met Glu Pro Val Leu Ile Ala
        675                 680                 685             
Val Gln Pro Leu Phe Gly Pro Arg Ala Gly Gly Thr Cys Leu Thr Leu
    690                 695                 700                 
Glu Gly Gln Ser Leu Ser Val Gly Thr Ser Arg Ala Val Leu Val Asn
705                 710                 715                 720 
Gly Thr Glu Cys Leu Leu Ala Arg Val Ser Glu Gly Gln Leu Leu Cys
                725                 730                 735     
Ala Thr Pro Pro Gly Ala Thr Val Ala Ser Val Pro Leu Ser Leu Gln
            740                 745                 750         
Val Gly Gly Ala Gln Val Pro Gly Ser Trp Thr Phe Gln Tyr Arg Glu
        755                 760                 765             
Asp Pro Val Val Leu Ser Ile Ser Pro Asn Cys Gly Tyr Ile Asn Ser
    770                 775                 780                 
His Ile Thr Ile Cys Gly Gln His Leu Thr Ser Ala Trp His Leu Val
785                 790                 795                 800 
Leu Ser Phe His Asp Gly Leu Arg Ala Val Glu Ser Arg Cys Glu Arg
                805                 810                 815     
Gln Leu Pro Glu Gln Gln Leu Cys Arg Leu Pro Glu Tyr Val Val Arg
            820                 825                 830         
Asp Pro Gln Gly Trp Val Ala Gly Asn Leu Ser Ala Arg Gly Asp Gly
        835                 840                 845             
Ala Ala Gly Phe Thr Leu Pro Gly Phe Arg Phe Leu Pro Pro Pro His
    850                 855                 860                 
Pro Pro Ser Ala Asn Leu Val Pro Leu Lys Pro Glu Glu His Ala Ile
865                 870                 875                 880 
Lys Phe Glu Tyr Ile Gly Leu Gly Ala Val Ala Asp Cys Val Gly Ile
                885                 890                 895     
Asn Val Thr Val Gly Gly Glu Ser Cys Gln His Glu Phe Arg Gly Asp
            900                 905                 910         
Met Val Val Cys Pro Leu Pro Pro Ser Leu Gln Leu Gly Gln Asp Gly
        915                 920                 925             
Ala Pro Leu Gln Val Cys Val Asp Gly Glu Cys His Ile Leu Gly Arg
    930                 935                 940                 
Val Xaa Arg Pro Gly Pro Asp Gly Val Pro Gln Ser Thr Leu Leu Gly
945                 950                 955                 960 
Ile Leu Leu Pro Leu Leu Leu Leu Val Ala Ala Leu Ala Thr Ala Leu
                965                 970                 975     
Val Phe Ser Tyr Trp Trp Arg Arg Lys Gln Leu Val Leu Pro Pro Asn
            980                 985                 990         
Leu Asn Asp Leu Ala Ser Leu Asp Gln Thr Ala Gly Ala Thr Pro Leu
        995                 1000                1005            
Pro Ile Leu Tyr Ser Gly Ser Asp Tyr Arg Ser Gly Leu Ala Leu Pro
    1010                1015                1020                
Ala Ile Asp Gly Leu Asp Ser Thr Thr Cys Val His Gly Ala Ser Phe
1025                1030                1035                1040
Ser Asp Ser Glu Asp Glu Ser Cys Val Pro Leu Leu Arg Lys Glu Ser
                1045                1050                1055    
Ile Gln Leu Arg Asp Leu Asp Ser Ala Leu Leu Ala Glu Val Lys Asp
            1060                1065                1070        
Val Leu Ile Pro His Glu Arg Val Val Thr His Ser Asp Arg Val Ile
        1075                1080                1085            
Gly Lys Gly His Phe Gly Val Val Tyr His Gly Glu Tyr Ile Asp Gln
    1090                1095                1100                
Ala Gln Asn Arg Ile Gln Cys Ala Ile Lys Ser Leu Ser Arg Ile Thr
1105                1110                1115                1120
Glu Met Gln Gln Val Glu Ala Phe Leu Arg Glu Gly Leu Leu Met Arg
                1125                1130                1135    
Gly Leu Asn His Pro Asn Val Leu Ala Leu Ile Gly Ile Met Leu Pro
            1140                1145                1150        
Pro Glu Gly Leu Pro His Val Leu Leu Pro Tyr Met Cys His Gly Asp
        1155                1160                1165            
Leu Leu Gln Phe Ile Arg Ser Pro Gln Arg Asn Pro Thr Val Lys Asp
    1170                1175                1180                
Leu Ile Ser Phe Gly Leu Gln Val Ala Arg Xaa Met Glu Tyr Leu Ala
1185                1190                1195                1200
Glu Gln Lys Phe Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu
                1205                1210                1215    
Asp Glu Ser Phe Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Xaa
            1220                1225                1230        
Ile Leu Asp Arg Glu Tyr Tyr Ser Val Gln Gln His Arg His Ala Arg
        1235                1240                1245            
Leu Pro Val Lys Trp Xaa Ala Leu Glu Ser Leu Gln Thr Tyr Arg Phe
    1250                1255                1260                
Thr Thr Lys Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Leu
1265                1270                1275                1280
Leu Thr Arg Gly Ala Pro Pro Tyr Arg His Ile Asp Pro Phe Asp Leu
                1285                1290                1295    
Thr His Phe Leu Ala Gln Gly Arg Arg Leu Pro Gln Pro Glu Tyr Cys
            1300                1305                1310        
Pro Asp Ser Leu Tyr Gln Val Met Gln Gln Cys Trp Glu Ala Asp Pro
        1315                1320                1325            
Ala Val Arg Pro Thr Phe Xaa Val Leu Val Gly Glu Val Glu Gln Ile
    1330                1335                1340                
Val Ser Ala Leu Leu Gly Asp His Tyr Val Gln Leu Pro Ala Thr Tyr
1345                1350                1355                1360
Met Asn Leu Gly Pro Ser Thr Ser His Glu Met Asn Val Arg Pro Glu
                1365                1370                1375    
Gln Pro Gln Phe Ser Pro Met Pro Gly Asn Val Arg Arg Pro Arg Pro
            1380                1385                1390        
Leu Ser Glu Pro Pro Arg Pro Thr
        1395                1400

<210> 449
<211> 972
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 279
<223> Xaa = V or M

<220> 
<221> VARIANT        
<222> 362
<223> Xaa = H or R

<220> 
<221> VARIANT        
<222> 969
<223> Xaa = Y or C

<400> 449
Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His
 1               5                  10                  15      
Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val
            20                  25                  30          
Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val
        35                  40                  45              
Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly
    50                  55                  60                  
Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly
65                  70                  75                  80  
Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala
                85                  90                  95      
Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala
            100                 105                 110         
Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu
        115                 120                 125             
Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg
    130                 135                 140                 
Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His
145                 150                 155                 160 
Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln
                165                 170                 175     
Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg
            180                 185                 190         
Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val
        195                 200                 205             
Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys
    210                 215                 220                 
Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn
225                 230                 235                 240 
Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg
                245                 250                 255     
Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His
            260                 265                 270         
Ala Gly Asn Tyr Ser Cys Xaa Ala Ser Asn Val Gln Gly Lys His Ser
        275                 280                 285             
Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser
    290                 295                 300                 
Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn
305                 310                 315                 320 
Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp
                325                 330                 335     
Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala
            340                 345                 350         
Asn Ala Thr Thr Lys Asp Thr Tyr Arg Xaa Thr Phe Thr Leu Ser Leu
        355                 360                 365             
Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg
    370                 375                 380                 
Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr
385                 390                 395                 400 
Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr
                405                 410                 415     
Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu
            420                 425                 430         
Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln
        435                 440                 445             
Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His
    450                 455                 460                 
Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn
465                 470                 475                 480 
Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp
                485                 490                 495     
Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu
            500                 505                 510         
Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu
        515                 520                 525             
Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro
    530                 535                 540                 
Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser
545                 550                 555                 560 
Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu
                565                 570                 575     
Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala
            580                 585                 590         
Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp
        595                 600                 605             
Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala
    610                 615                 620                 
Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu
625                 630                 635                 640 
Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly
                645                 650                 655     
Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu
            660                 665                 670         
Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser
        675                 680                 685             
Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu
    690                 695                 700                 
Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val
705                 710                 715                 720 
Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser
                725                 730                 735     
Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu
            740                 745                 750         
Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe
        755                 760                 765             
Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val
    770                 775                 780                 
Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala
785                 790                 795                 800 
Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg
                805                 810                 815     
Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr
            820                 825                 830         
Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile
        835                 840                 845             
Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys
    850                 855                 860                 
Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe
865                 870                 875                 880 
Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu
                885                 890                 895     
Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu
            900                 905                 910         
Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser
        915                 920                 925             
Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu
    930                 935                 940                 
Glu Ser Ser Ser Glu His Leu Thr Cys Cys Glu Gln Gly Asp Ile Ala
945                 950                 955                 960 
Gln Pro Leu Leu Gln Pro Asn Asn Xaa Gln Phe Cys
                965                 970         

<210> 450
<211> 993
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 835
<223> Xaa = D or Y or H or F

<220> 
<221> VARIANT        
<222> 836
<223> Xaa = I or S

<220> 
<221> VARIANT        
<222> 841
<223> Xaa = N or I

<220> 
<221> VARIANT        
<222> 842
<223> Xaa = Y or H

<400> 450
Met Pro Ala Leu Ala Arg Asp Ala Gly Thr Val Pro Leu Leu Val Val
 1               5                  10                  15      
Phe Ser Ala Met Ile Phe Gly Thr Ile Thr Asn Gln Asp Leu Pro Val
            20                  25                  30          
Ile Lys Cys Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val Gly
        35                  40                  45              
Lys Ser Ser Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly
    50                  55                  60                  
Cys Ala Leu Arg Pro Gln Ser Ser Gly Thr Val Tyr Glu Ala Ala Ala
65                  70                  75                  80  
Val Glu Val Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val Asp
                85                  90                  95      
Ala Pro Gly Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu
            100                 105                 110         
Asn Cys Gln Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser Met
        115                 120                 125             
Val Ile Leu Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu Phe
    130                 135                 140                 
Ile Gln Ser Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser Ile
145                 150                 155                 160 
Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met
                165                 170                 175     
Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro
            180                 185                 190         
Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu
        195                 200                 205             
Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu
    210                 215                 220                 
Phe Gly Thr Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu
225                 230                 235                 240 
Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr Thr
                245                 250                 255     
Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg Cys
            260                 265                 270         
Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu
        275                 280                 285             
Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser
    290                 295                 300                 
Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser Val
305                 310                 315                 320 
Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro
                325                 330                 335     
Ser Gln Ser Ala Leu Val Thr Ile Val Gly Lys Gly Phe Ile Asn Ala
            340                 345                 350         
Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe Cys
        355                 360                 365             
Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp Thr
    370                 375                 380                 
Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn Gly
385                 390                 395                 400 
Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu Tyr
                405                 410                 415     
Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe Thr
            420                 425                 430         
Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser
        435                 440                 445             
Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp
    450                 455                 460                 
Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu
465                 470                 475                 480 
Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val
                485                 490                 495     
Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val
            500                 505                 510         
Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu
        515                 520                 525             
Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser Phe
    530                 535                 540                 
Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr Leu
545                 550                 555                 560 
Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln Leu
                565                 570                 575     
Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr Val
            580                 585                 590         
Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg Glu
        595                 600                 605             
Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys Val
    610                 615                 620                 
Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile Gln
625                 630                 635                 640 
Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg Glu
                645                 650                 655     
Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His Glu
            660                 665                 670         
Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile Tyr
        675                 680                 685             
Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu Arg
    690                 695                 700                 
Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys Glu
705                 710                 715                 720 
His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser Ser
                725                 730                 735     
Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln Ile
            740                 745                 750         
Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu Tyr
        755                 760                 765             
Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu Thr
    770                 775                 780                 
Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met Glu
785                 790                 795                 800 
Phe Leu Glu Phe Lys Ser Cys Val His Arg Asp Leu Ala Ala Arg Asn
                805                 810                 815     
Val Leu Val Thr His Gly Lys Val Val Lys Ile Cys Asp Phe Gly Leu
            820                 825                 830         
Ala Arg Xaa Xaa Met Ser Asp Ser Xaa Xaa Val Val Arg Gly Asn Ala
        835                 840                 845             
Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Leu Phe Glu Gly Ile
    850                 855                 860                 
Tyr Thr Ile Lys Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu
865                 870                 875                 880 
Ile Phe Ser Leu Gly Val Asn Pro Tyr Pro Gly Ile Pro Val Asp Ala
                885                 890                 895     
Asn Phe Tyr Lys Leu Ile Gln Asn Gly Phe Lys Met Asp Gln Pro Phe
            900                 905                 910         
Tyr Ala Thr Glu Glu Ile Tyr Ile Ile Met Gln Ser Cys Trp Ala Phe
        915                 920                 925             
Asp Ser Arg Lys Arg Pro Ser Phe Pro Asn Leu Thr Ser Phe Leu Gly
    930                 935                 940                 
Cys Gln Leu Ala Asp Ala Glu Glu Ala Met Tyr Gln Asn Val Asp Gly
945                 950                 955                 960 
Arg Val Ser Glu Cys Pro His Thr Tyr Gln Asn Arg Arg Pro Phe Ser
                965                 970                 975     
Arg Glu Met Asp Leu Gly Leu Leu Ser Pro Gln Ala Gln Val Glu Asp
            980                 985                 990         
Ser
    


<210> 451
<211> 976
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 541
<223> Xaa = M or L or V

<220> 
<221> VARIANT        
<222> 557
<223> Xaa = W or R

<220> 
<221> VARIANT        
<222> 664
<223> Xaa = G or R

<220> 
<221> VARIANT        
<222> 788, 136
<223> Xaa = C or R

<220> 
<221> VARIANT        
<222> 802
<223> Xaa = T or I

<220> 
<221> VARIANT        
<222> 816, 820
<223> Xaa = D or V or H or Y

<220> 
<221> VARIANT        
<222> 822
<223> Xaa = N or Y or K

<220> 
<221> VARIANT        
<222> 823
<223> Xaa = Y or D or C

<220> 
<221> VARIANT        
<222> 835
<223> Xaa = W or R

<220> 
<221> VARIANT        
<222> 869
<223> Xaa = P or S

<220> 
<221> VARIANT        
<222> 900
<223> Xaa = Y or F

<220> 
<221> VARIANT        
<222> 52
<223> Xaa = D or N

<220> 
<221> VARIANT        
<222> 178
<223> Xaa = A or T

<400> 451
Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu
 1               5                  10                  15      
Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly
            20                  25                  30          
Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val
        35                  40                  45              
Arg Val Gly Xaa Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val
    50                  55                  60                  
Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn
65                  70                  75                  80  
Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr
                85                  90                  95      
Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg
            100                 105                 110         
Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu
        115                 120                 125             
Asp Asn Asp Thr Leu Val Arg Xaa Pro Leu Thr Asp Pro Glu Val Thr
    130                 135                 140                 
Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu
145                 150                 155                 160 
Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys
                165                 170                 175     
Arg Xaa Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly
            180                 185                 190         
Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe
        195                 200                 205             
Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg
    210                 215                 220                 
Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser
225                 230                 235                 240 
Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln
                245                 250                 255     
Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln
            260                 265                 270         
Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe
        275                 280                 285             
Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr
    290                 295                 300                 
Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn
305                 310                 315                 320 
Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu
                325                 330                 335     
Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn
            340                 345                 350         
Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu
        355                 360                 365             
Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly
    370                 375                 380                 
Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn
385                 390                 395                 400 
Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu
                405                 410                 415     
Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly
            420                 425                 430         
Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln
        435                 440                 445             
Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser
    450                 455                 460                 
Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser
465                 470                 475                 480 
Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp
                485                 490                 495     
Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn
            500                 505                 510         
Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly
        515                 520                 525             
Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Xaa Ile Leu Thr
    530                 535                 540                 
Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Xaa Lys Val Val
545                 550                 555                 560 
Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu
                565                 570                 575     
Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly
            580                 585                 590         
Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala
        595                 600                 605             
Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met
    610                 615                 620                 
Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu
625                 630                 635                 640 
Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu
                645                 650                 655     
Leu Gly Ala Cys Thr Ile Gly Xaa Pro Thr Leu Val Ile Thr Glu Tyr
            660                 665                 670         
Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser
        675                 680                 685             
Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys
    690                 695                 700                 
Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu
705                 710                 715                 720 
Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala
                725                 730                 735     
Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val
            740                 745                 750         
Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp
        755                 760                 765             
Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala
    770                 775                 780                 
Ser Lys Asn Xaa Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu
785                 790                 795                 800 
Xaa His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Xaa
                805                 810                 815     
Ile Lys Asn Xaa Ser Xaa Xaa Val Val Lys Gly Asn Ala Arg Leu Pro
            820                 825                 830         
Val Lys Xaa Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe
        835                 840                 845             
Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser
    850                 855                 860                 
Leu Gly Ser Ser Xaa Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr
865                 870                 875                 880 
Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro
                885                 890                 895     
Ala Glu Met Xaa Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu
            900                 905                 910         
Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile
        915                 920                 925             
Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro
    930                 935                 940                 
Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val
945                 950                 955                 960 
Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val
                965                 970                 975     

<210> 452
<211> 1106
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 29
<223> Xaa = I or F

<220> 
<221> VARIANT        
<222> 194
<223> Xaa = I or T

<220> 
<221> VARIANT        
<222> 345
<223> Xaa = P or S

<400> 452
Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu
 1               5                  10                  15      
Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Xaa Ser Gln Gly
            20                  25                  30          
Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser
        35                  40                  45              
Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg
    50                  55                  60                  
Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr
65                  70                  75                  80  
Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly
                85                  90                  95      
Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu
            100                 105                 110         
Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu
        115                 120                 125             
Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu
    130                 135                 140                 
Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu
145                 150                 155                 160 
His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln
                165                 170                 175     
Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr
            180                 185                 190         
Thr Xaa Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg
        195                 200                 205             
Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val
    210                 215                 220                 
Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn
225                 230                 235                 240 
Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg
                245                 250                 255     
Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile
            260                 265                 270         
Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr
        275                 280                 285             
Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys
    290                 295                 300                 
Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly
305                 310                 315                 320 
Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu
                325                 330                 335     
Gln Val Val Phe Glu Ala Tyr Pro Xaa Pro Thr Val Leu Trp Phe Lys
            340                 345                 350         
Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser
        355                 360                 365             
Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val
    370                 375                 380                 
Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His
385                 390                 395                 400 
Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro
                405                 410                 415     
Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln
            420                 425                 430         
Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp
        435                 440                 445             
Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr
    450                 455                 460                 
Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val
465                 470                 475                 480 
Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg
                485                 490                 495     
Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn
            500                 505                 510         
Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu
        515                 520                 525             
Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu
    530                 535                 540                 
Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro
545                 550                 555                 560 
Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly
                565                 570                 575     
His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr
            580                 585                 590         
Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser
        595                 600                 605             
Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His
    610                 615                 620                 
Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala
625                 630                 635                 640 
Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser
                645                 650                 655     
His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr
            660                 665                 670         
Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp
        675                 680                 685             
Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His
    690                 695                 700                 
Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu
705                 710                 715                 720 
Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser
                725                 730                 735     
Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val
            740                 745                 750         
Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser
        755                 760                 765             
Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu
    770                 775                 780                 
Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr
785                 790                 795                 800 
Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe
                805                 810                 815     
Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val
            820                 825                 830         
Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala
        835                 840                 845             
Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe
    850                 855                 860                 
Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr
865                 870                 875                 880 
Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile
                885                 890                 895     
Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln
            900                 905                 910         
Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His
        915                 920                 925             
Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys
    930                 935                 940                 
Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg
945                 950                 955                 960 
Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu
                965                 970                 975     
Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu
            980                 985                 990         
Pro Gly Phe His Gly Leu Arg Ser Pro Leu Asp Thr Ser Ser Val Leu
        995                 1000                1005            
Tyr Thr Ala Val Gln Pro Asn Glu Gly Asp Asn Asp Tyr Ile Ile Pro
    1010                1015                1020                
Leu Pro Asp Pro Lys Pro Glu Val Ala Asp Glu Gly Pro Leu Glu Gly
1025                1030                1035                1040
Ser Pro Ser Leu Ala Ser Ser Thr Leu Asn Glu Val Asn Thr Ser Ser
                1045                1050                1055    
Thr Ile Ser Cys Asp Ser Pro Leu Glu Pro Gln Asp Glu Pro Glu Pro
            1060                1065                1070        
Glu Pro Gln Leu Glu Leu Gln Val Glu Pro Glu Pro Glu Leu Glu Gln
        1075                1080                1085            
Leu Pro Asp Ser Gly Cys Pro Ala Pro Arg Ala Glu Ala Glu Asp Ser
    1090                1095                1100                
Phe Leu
1105    

<210> 453
<211> 404
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 77
<223> Xaa = C, R

<220> 
<221> VARIANT        
<222> 82
<223> Xaa = G, S

<220> 
<221> VARIANT        
<222> 305
<223> Xaa = H, Q

<220> 
<221> VARIANT        
<222> 307
<223> Xaa = C, S

<220> 
<221> VARIANT        
<222> 365
<223> Xaa = R, S

<220> 
<221> VARIANT        
<222> 369
<223> Xaa = G, Q, R  

<400> 453
Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu
 1               5                  10                  15      
Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu
            20                  25                  30          
Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg
        35                  40                  45              
Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu
    50                  55                  60                  
Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Xaa Val Leu Pro
65                  70                  75                  80  
Asn Xaa Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile
                85                  90                  95      
Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn
            100                 105                 110         
Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp
        115                 120                 125             
Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys
    130                 135                 140                 
Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp
145                 150                 155                 160 
Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln
                165                 170                 175     
Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu
            180                 185                 190         
Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys
        195                 200                 205             
Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro
    210                 215                 220                 
Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu
225                 230                 235                 240 
Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr
                245                 250                 255     
Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met
            260                 265                 270         
Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu
        275                 280                 285             
Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr
    290                 295                 300                 
Xaa Ser Xaa His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile
305                 310                 315                 320 
Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser
                325                 330                 335     
Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly
            340                 345                 350         
Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Xaa Arg Gln Arg
        355                 360                 365             
Xaa Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu
    370                 375                 380                 
Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser
385                 390                 395                 400 
Thr Gly Gly Pro
                

<210> 454
<211> 1124
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 346
<223> Xaa = P or Q

<220> 
<221> VARIANT        
<222> 486
<223> Xaa = V or I

<220> 
<221> VARIANT        
<222> 695
<223> Xaa = I or T

<220> 
<221> VARIANT        
<222> 724
<223> Xaa = A or T

<220> 
<221> VARIANT        
<222> 849
<223> Xaa = R or W

<400> 454
Met Asp Ser Leu Ala Ser Leu Val Leu Cys Gly Val Ser Leu Leu Leu
 1               5                  10                  15      
Ser Gly Thr Val Glu Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu
            20                  25                  30          
Pro Leu Val Ser Asp Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly
        35                  40                  45              
Trp Arg Pro His Glu Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu
    50                  55                  60                  
Met Asn Gln His Gln Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg
65                  70                  75                  80  
Glu Trp Ala Lys Lys Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile
                85                  90                  95      
Asn Gly Ala Tyr Phe Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg
            100                 105                 110         
Ile Arg Thr Met Lys Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr
        115                 120                 125             
Leu Thr Met Thr Val Asp Lys Gly Asp Asn Val Asn Ile Ser Phe Lys
    130                 135                 140                 
Lys Val Leu Ile Lys Glu Glu Asp Ala Val Ile Tyr Lys Asn Gly Ser
145                 150                 155                 160 
Phe Ile His Ser Val Pro Arg His Glu Val Pro Asp Ile Leu Glu Val
                165                 170                 175     
His Leu Pro His Ala Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg
            180                 185                 190         
Tyr Ile Gly Gly Asn Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val
        195                 200                 205             
Arg Arg Cys Glu Ala Gln Lys Trp Gly Pro Glu Cys Asn His Leu Cys
    210                 215                 220                 
Thr Ala Cys Met Asn Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys
225                 230                 235                 240 
Ile Cys Pro Pro Gly Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu
                245                 250                 255     
Leu His Thr Phe Gly Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Glu
            260                 265                 270         
Gly Cys Lys Ser Tyr Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser
        275                 280                 285             
Cys Ala Thr Gly Trp Lys Gly Leu Gln Cys Asn Glu Ala Cys His Pro
    290                 295                 300                 
Gly Phe Tyr Gly Pro Asp Cys Lys Leu Arg Cys Ser Cys Asn Asn Gly
305                 310                 315                 320 
Glu Met Cys Asp Arg Phe Gln Gly Cys Leu Cys Ser Pro Gly Trp Gln
                325                 330                 335     
Gly Leu Gln Cys Glu Arg Glu Gly Ile Xaa Arg Met Thr Pro Lys Ile
            340                 345                 350         
Val Asp Leu Pro Asp His Ile Glu Val Asn Ser Gly Lys Phe Asn Pro
        355                 360                 365             
Ile Cys Lys Ala Ser Gly Trp Pro Leu Pro Thr Asn Glu Glu Met Thr
    370                 375                 380                 
Leu Val Lys Pro Asp Gly Thr Val Leu His Pro Lys Asp Phe Asn His
385                 390                 395                 400 
Thr Asp His Phe Ser Val Ala Ile Phe Thr Ile His Arg Ile Leu Pro
                405                 410                 415     
Pro Asp Ser Gly Val Trp Val Cys Ser Val Asn Thr Val Ala Gly Met
            420                 425                 430         
Val Glu Lys Pro Phe Asn Ile Ser Val Lys Val Leu Pro Lys Pro Leu
        435                 440                 445             
Asn Ala Pro Asn Val Ile Asp Thr Gly His Asn Phe Ala Val Ile Asn
    450                 455                 460                 
Ile Ser Ser Glu Pro Tyr Phe Gly Asp Gly Pro Ile Lys Ser Lys Lys
465                 470                 475                 480 
Leu Leu Tyr Lys Pro Xaa Asn His Tyr Glu Ala Trp Gln His Ile Gln
                485                 490                 495     
Val Thr Asn Glu Ile Val Thr Leu Asn Tyr Leu Glu Pro Arg Thr Glu
            500                 505                 510         
Tyr Glu Leu Cys Val Gln Leu Val Arg Arg Gly Glu Gly Gly Glu Gly
        515                 520                 525             
His Pro Gly Pro Val Arg Arg Phe Thr Thr Ala Ser Ile Gly Leu Pro
    530                 535                 540                 
Pro Pro Arg Gly Leu Asn Leu Leu Pro Lys Ser Gln Thr Thr Leu Asn
545                 550                 555                 560 
Leu Thr Trp Gln Pro Ile Phe Pro Ser Ser Glu Asp Asp Phe Tyr Val
                565                 570                 575     
Glu Val Glu Arg Arg Ser Val Gln Lys Ser Asp Gln Gln Asn Ile Lys
            580                 585                 590         
Val Pro Gly Asn Leu Thr Ser Val Leu Leu Asn Asn Leu His Pro Arg
        595                 600                 605             
Glu Gln Tyr Val Val Arg Ala Arg Val Asn Thr Lys Ala Gln Gly Glu
    610                 615                 620                 
Trp Ser Glu Asp Leu Thr Ala Trp Thr Leu Ser Asp Ile Leu Pro Pro
625                 630                 635                 640 
Gln Pro Glu Asn Ile Lys Ile Ser Asn Ile Thr His Ser Ser Ala Val
                645                 650                 655     
Ile Ser Trp Thr Ile Leu Asp Gly Tyr Ser Ile Ser Ser Ile Thr Ile
            660                 665                 670         
Arg Tyr Lys Val Gln Gly Lys Asn Glu Asp Gln His Val Asp Val Lys
        675                 680                 685             
Ile Lys Asn Ala Thr Ile Xaa Gln Tyr Gln Leu Lys Gly Leu Glu Pro
    690                 695                 700                 
Glu Thr Ala Tyr Gln Val Asp Ile Phe Ala Glu Asn Asn Ile Gly Ser
705                 710                 715                 720 
Ser Asn Pro Xaa Phe Ser His Glu Leu Val Thr Leu Pro Glu Ser Gln
                725                 730                 735     
Ala Pro Ala Asp Leu Gly Gly Gly Lys Met Leu Leu Ile Ala Ile Leu
            740                 745                 750         
Gly Ser Ala Gly Met Thr Cys Leu Thr Val Leu Leu Ala Phe Leu Ile
        755                 760                 765             
Ile Leu Gln Leu Lys Arg Ala Asn Val Gln Arg Arg Met Ala Gln Ala
    770                 775                 780                 
Phe Gln Asn Val Arg Glu Glu Pro Ala Val Gln Phe Asn Ser Gly Thr
785                 790                 795                 800 
Leu Ala Leu Asn Arg Lys Val Lys Asn Asn Pro Asp Pro Thr Ile Tyr
                805                 810                 815     
Pro Val Leu Asp Trp Asn Asp Ile Lys Phe Gln Asp Val Ile Gly Glu
            820                 825                 830         
Gly Asn Phe Gly Gln Val Leu Lys Ala Arg Ile Lys Lys Asp Gly Leu
        835                 840                 845             
Xaa Met Asp Ala Ala Ile Lys Arg Met Lys Glu Tyr Ala Ser Lys Asp
    850                 855                 860                 
Asp His Arg Asp Phe Ala Gly Glu Leu Glu Val Leu Cys Lys Leu Gly
865                 870                 875                 880 
His His Pro Asn Ile Ile Asn Leu Leu Gly Ala Cys Glu His Arg Gly
                885                 890                 895     
Tyr Leu Tyr Leu Ala Ile Glu Tyr Ala Pro His Gly Asn Leu Leu Asp
            900                 905                 910         
Phe Leu Arg Lys Ser Arg Val Leu Glu Thr Asp Pro Ala Phe Ala Ile
        915                 920                 925             
Ala Asn Ser Thr Ala Ser Thr Leu Ser Ser Gln Gln Leu Leu His Phe
    930                 935                 940                 
Ala Ala Asp Val Ala Arg Gly Met Asp Tyr Leu Ser Gln Lys Gln Phe
945                 950                 955                 960 
Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Gly Glu Asn Tyr
                965                 970                 975     
Val Ala Lys Ile Ala Asp Phe Gly Leu Ser Arg Gly Gln Glu Val Tyr
            980                 985                 990         
Val Lys Lys Thr Met Gly Arg Leu Pro Val Arg Trp Met Ala Ile Glu
        995                 1000                1005            
Ser Leu Asn Tyr Ser Val Tyr Thr Thr Asn Ser Asp Val Trp Ser Tyr
    1010                1015                1020                
Gly Val Leu Leu Trp Glu Ile Val Ser Leu Gly Gly Thr Pro Tyr Cys
1025                1030                1035                1040
Gly Met Thr Cys Ala Glu Leu Tyr Glu Lys Leu Pro Gln Gly Tyr Arg
                1045                1050                1055    
Leu Glu Lys Pro Leu Asn Cys Asp Asp Glu Val Tyr Asp Leu Met Arg
            1060                1065                1070        
Gln Cys Trp Arg Glu Lys Pro Tyr Glu Arg Pro Ser Phe Ala Gln Ile
        1075                1080                1085            
Leu Val Ser Leu Asn Arg Met Leu Glu Glu Arg Lys Thr Tyr Val Asn
    1090                1095                1100                
Thr Thr Leu Tyr Glu Lys Phe Thr Tyr Ala Gly Ile Asp Cys Ser Ala
1105                1110                1115                1120
Glu Glu Ala Ala
                


<210> 455
<211> 1138
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 142
<223> Xaa = A or T

<220> 
<221> VARIANT        
<222> 1109
<223> Xaa = R or C

<400> 455
Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala
 1               5                  10                  15      
Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg
            20                  25                  30          
Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala
        35                  40                  45              
Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu
    50                  55                  60                  
Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu
65                  70                  75                  80  
Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro
                85                  90                  95      
Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg
            100                 105                 110         
Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu
        115                 120                 125             
Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Xaa Val Leu
    130                 135                 140                 
Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser
145                 150                 155                 160 
Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly
                165                 170                 175     
Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile
            180                 185                 190         
Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly Ser Ala Phe Phe
        195                 200                 205             
Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp Gly Pro Gly Cys
    210                 215                 220                 
Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val Cys His Asp His
225                 230                 235                 240 
Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly Thr Arg Cys Glu
                245                 250                 255     
Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys Gln Glu Gln Cys
            260                 265                 270         
Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys Leu Pro Asp Pro
        275                 280                 285             
Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser Gln Cys Gln Glu
    290                 295                 300                 
Ala Cys Ala Pro Gly His Phe Gly Ala Asp Cys Arg Leu Gln Cys Gln
305                 310                 315                 320 
Cys Gln Asn Gly Gly Thr Cys Asp Arg Phe Ser Gly Cys Val Cys Pro
                325                 330                 335     
Ser Gly Trp His Gly Val His Cys Glu Lys Ser Asp Arg Ile Pro Gln
            340                 345                 350         
Ile Leu Asn Met Ala Ser Glu Leu Glu Phe Asn Leu Glu Thr Met Pro
        355                 360                 365             
Arg Ile Asn Cys Ala Ala Ala Gly Asn Pro Phe Pro Val Arg Gly Ser
    370                 375                 380                 
Ile Glu Leu Arg Lys Pro Asp Gly Thr Val Leu Leu Ser Thr Lys Ala
385                 390                 395                 400 
Ile Val Glu Pro Glu Lys Thr Thr Ala Glu Phe Glu Val Pro Arg Leu
                405                 410                 415     
Val Leu Ala Asp Ser Gly Phe Trp Glu Cys Arg Val Ser Thr Ser Gly
            420                 425                 430         
Gly Gln Asp Ser Arg Arg Phe Lys Val Asn Val Lys Val Pro Pro Val
        435                 440                 445             
Pro Leu Ala Ala Pro Arg Leu Leu Thr Lys Gln Ser Arg Gln Leu Val
    450                 455                 460                 
Val Ser Pro Leu Val Ser Phe Ser Gly Asp Gly Pro Ile Ser Thr Val
465                 470                 475                 480 
Arg Leu His Tyr Arg Pro Gln Asp Ser Thr Met Asp Trp Ser Thr Ile
                485                 490                 495     
Val Val Asp Pro Ser Glu Asn Val Thr Leu Met Asn Leu Arg Pro Lys
            500                 505                 510         
Thr Gly Tyr Ser Val Arg Val Gln Leu Ser Arg Pro Gly Glu Gly Gly
        515                 520                 525             
Glu Gly Ala Trp Gly Pro Pro Thr Leu Met Thr Thr Asp Cys Pro Glu
    530                 535                 540                 
Pro Leu Leu Gln Pro Trp Leu Glu Gly Trp His Val Glu Gly Thr Asp
545                 550                 555                 560 
Arg Leu Arg Val Ser Trp Ser Leu Pro Leu Val Pro Gly Pro Leu Val
                565                 570                 575     
Gly Asp Gly Phe Leu Leu Arg Leu Trp Asp Gly Thr Arg Gly Gln Glu
            580                 585                 590         
Arg Arg Glu Asn Val Ser Ser Pro Gln Ala Arg Thr Ala Leu Leu Thr
        595                 600                 605             
Gly Leu Thr Pro Gly Thr His Tyr Gln Leu Asp Val Gln Leu Tyr His
    610                 615                 620                 
Cys Thr Leu Leu Gly Pro Ala Ser Pro Pro Ala His Val Leu Leu Pro
625                 630                 635                 640 
Pro Ser Gly Pro Pro Ala Pro Arg His Leu His Ala Gln Ala Leu Ser
                645                 650                 655     
Asp Ser Glu Ile Gln Leu Thr Trp Lys His Pro Glu Ala Leu Pro Gly
            660                 665                 670         
Pro Ile Ser Lys Tyr Val Val Glu Val Gln Val Ala Gly Gly Ala Gly
        675                 680                 685             
Asp Pro Leu Trp Ile Asp Val Asp Arg Pro Glu Glu Thr Ser Thr Ile
    690                 695                 700                 
Ile Arg Gly Leu Asn Ala Ser Thr Arg Tyr Leu Phe Arg Met Arg Ala
705                 710                 715                 720 
Ser Ile Gln Gly Leu Gly Asp Trp Ser Asn Thr Val Glu Glu Ser Thr
                725                 730                 735     
Leu Gly Asn Gly Leu Gln Ala Glu Gly Pro Val Gln Glu Ser Arg Ala
            740                 745                 750         
Ala Glu Glu Gly Leu Asp Gln Gln Leu Ile Leu Ala Val Val Gly Ser
        755                 760                 765             
Val Ser Ala Thr Cys Leu Thr Ile Leu Ala Ala Leu Leu Thr Leu Val
    770                 775                 780                 
Cys Ile Arg Arg Ser Cys Leu His Arg Arg Arg Thr Phe Thr Tyr Gln
785                 790                 795                 800 
Ser Gly Ser Gly Glu Glu Thr Ile Leu Gln Phe Ser Ser Gly Thr Leu
                805                 810                 815     
Thr Leu Thr Arg Arg Pro Lys Leu Gln Pro Glu Pro Leu Ser Tyr Pro
            820                 825                 830         
Val Leu Glu Trp Glu Asp Ile Thr Phe Glu Asp Leu Ile Gly Glu Gly
        835                 840                 845             
Asn Phe Gly Gln Val Ile Arg Ala Met Ile Lys Lys Asp Gly Leu Lys
    850                 855                 860                 
Met Asn Ala Ala Ile Lys Met Leu Lys Glu Tyr Ala Ser Glu Asn Asp
865                 870                 875                 880 
His Arg Asp Phe Ala Gly Glu Leu Glu Val Leu Cys Lys Leu Gly His
                885                 890                 895     
His Pro Asn Ile Ile Asn Leu Leu Gly Ala Cys Lys Asn Arg Gly Tyr
            900                 905                 910         
Leu Tyr Ile Ala Ile Glu Tyr Ala Pro Tyr Gly Asn Leu Leu Asp Phe
        915                 920                 925             
Leu Arg Lys Ser Arg Val Leu Glu Thr Asp Pro Ala Phe Ala Arg Glu
    930                 935                 940                 
His Gly Thr Ala Ser Thr Leu Ser Ser Arg Gln Leu Leu Arg Phe Ala
945                 950                 955                 960 
Ser Asp Ala Ala Asn Gly Met Gln Tyr Leu Ser Glu Lys Gln Phe Ile
                965                 970                 975     
His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Gly Glu Asn Leu Ala
            980                 985                 990         
Ser Lys Ile Ala Asp Phe Gly Leu Ser Arg Gly Glu Glu Val Tyr Val
        995                 1000                1005            
Lys Lys Thr Met Gly Arg Leu Pro Val Arg Trp Met Ala Ile Glu Ser
    1010                1015                1020                
Leu Asn Tyr Ser Val Tyr Thr Thr Lys Ser Asp Val Trp Ser Phe Gly
1025                1030                1035                1040
Val Leu Leu Trp Glu Ile Val Ser Leu Gly Gly Thr Pro Tyr Cys Gly
                1045                1050                1055    
Met Thr Cys Ala Glu Leu Tyr Glu Lys Leu Pro Gln Gly Tyr Arg Met
            1060                1065                1070        
Glu Gln Pro Arg Asn Cys Asp Asp Glu Val Tyr Glu Leu Met Arg Gln
        1075                1080                1085            
Cys Trp Arg Asp Arg Pro Tyr Glu Arg Pro Pro Phe Ala Gln Ile Ala
    1090                1095                1100                
Leu Gln Leu Gly Xaa Met Leu Glu Ala Arg Lys Ala Tyr Val Asn Met
1105                1110                1115                1120
Ser Leu Phe Glu Asn Phe Thr Tyr Ala Gly Ile Asp Ala Thr Ala Glu
                1125                1130                1135    
Glu Ala
        


<210> 456
<211> 455
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 75
<223> Xaa = P or I

<220> 
<221> VARIANT        
<222> 121
<223> Xaa = R or Q

<220> 
<221> VARIANT        
<222> 305
<223> Xaa = P or T

<400> 456
Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu
 1               5                  10                  15      
Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro
            20                  25                  30          
His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys
        35                  40                  45              
Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys
    50                  55                  60                  
Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Xaa Gly Gln Asp Thr Asp
65                  70                  75                  80  
Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu
                85                  90                  95      
Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val
            100                 105                 110         
Glu Ile Ser Ser Cys Thr Val Asp Xaa Asp Thr Val Cys Gly Cys Arg
        115                 120                 125             
Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe
    130                 135                 140                 
Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu
145                 150                 155                 160 
Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu
                165                 170                 175     
Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr
            180                 185                 190         
Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser
        195                 200                 205             
Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu
    210                 215                 220                 
Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys
225                 230                 235                 240 
Ser Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu
                245                 250                 255     
Gly Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser
            260                 265                 270         
Phe Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val
        275                 280                 285             
Pro Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys
    290                 295                 300                 
Xaa Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly
305                 310                 315                 320 
Ala Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn
                325                 330                 335     
Pro Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp
            340                 345                 350         
Thr Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro
        355                 360                 365             
Leu Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu
    370                 375                 380                 
Ile Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln
385                 390                 395                 400 
Tyr Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Pro Arg Arg Glu Ala
                405                 410                 415     
Thr Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly
            420                 425                 430         
Cys Leu Glu Asp Ile Glu Glu Ala Leu Cys Gly Pro Ala Ala Leu Pro
        435                 440                 445             
Pro Ala Pro Ser Leu Leu Arg
    450                 455 


<210> 457
<211> 461
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 187
<223> Xaa = V or M

<220> 
<221> VARIANT        
<222> 196
<223> Xaa = M or R

<220> 
<221> VARIANT        
<222> 232
<223> Xaa = E or K

<220> 
<221> VARIANT        
<222> 236
<223> Xaa = A or T

<220> 
<221> VARIANT        
<222> 264
<223> Xaa = L or P

<220> 
<221> VARIANT        
<222> 295
<223> Xaa = Q or R

<400> 457
Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu
 1               5                  10                  15      
Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr
            20                  25                  30          
Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln
        35                  40                  45              
Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys
    50                  55                  60                  
Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp
65                  70                  75                  80  
Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys
                85                  90                  95      
Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg
            100                 105                 110         
Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu
        115                 120                 125             
Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg
    130                 135                 140                 
Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val
145                 150                 155                 160 
Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr
                165                 170                 175     
Asp Ile Cys Arg Pro His Gln Ile Cys Asn Xaa Val Ala Ile Pro Gly
            180                 185                 190         
Asn Ala Ser Xaa Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser
        195                 200                 205             
Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser
    210                 215                 220                 
Gln His Thr Gln Pro Thr Pro Xaa Pro Ser Thr Xaa Pro Ser Thr Ser
225                 230                 235                 240 
Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly
                245                 250                 255     
Asp Phe Ala Leu Pro Val Gly Xaa Ile Val Gly Val Thr Ala Leu Gly
            260                 265                 270         
Leu Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val Lys
        275                 280                 285             
Lys Lys Pro Leu Cys Leu Xaa Arg Glu Ala Lys Val Pro His Leu Pro
    290                 295                 300                 
Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His Leu Leu
305                 310                 315                 320 
Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser
                325                 330                 335     
Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly
            340                 345                 350         
Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser
        355                 360                 365             
Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile
    370                 375                 380                 
Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser Gln
385                 390                 395                 400 
Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu Ser Pro
                405                 410                 415     
Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser
            420                 425                 430         
Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro
        435                 440                 445             
Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser
    450                 455                 460     


<210> 458
<211> 1356
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 297, 952
<223> Xaa = V or I

<220> 
<221> VARIANT        
<222> 349
<223> Xaa = R or K

<220> 
<221> VARIANT        
<222> 392
<223> Xaa = D or N

<220> 
<221> VARIANT        
<222> 472
<223> Xaa = Q or H

<220> 
<221> VARIANT        
<222> 772
<223> Xaa = A or T

<220> 
<221> VARIANT        
<222> 787
<223> Xaa = R or G

<220> 
<221> VARIANT        
<222> 835
<223> Xaa = K or N

<220> 
<221> VARIANT        
<222> 848
<223> Xaa = V or E

<220> 
<221> VARIANT        
<222> 1147
<223> Xaa = P or S

<220> 
<221> VARIANT        
<222> 1210
<223> Xaa = P or A

<220> 
<221> VARIANT        
<222> 1347
<223> Xaa = S or T

<400> 458
Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu
 1               5                  10                  15      
Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro
            20                  25                  30          
Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr
        35                  40                  45              
Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro
    50                  55                  60                  
Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser
65                  70                  75                  80  
Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn
                85                  90                  95      
Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser
            100                 105                 110         
Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser
        115                 120                 125             
Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys
    130                 135                 140                 
Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser
145                 150                 155                 160 
Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg
                165                 170                 175     
Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile
            180                 185                 190         
Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser
        195                 200                 205             
Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr
    210                 215                 220                 
Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu
225                 230                 235                 240 
Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile
                245                 250                 255     
Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu
            260                 265                 270         
Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe
        275                 280                 285             
Leu Ser Thr Leu Thr Ile Asp Gly Xaa Thr Arg Ser Asp Gln Gly Leu
    290                 295                 300                 
Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr
305                 310                 315                 320 
Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met
                325                 330                 335     
Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Xaa Ile Pro Ala
            340                 345                 350         
Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly
        355                 360                 365             
Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr
    370                 375                 380                 
Ile Met Glu Val Ser Glu Arg Xaa Thr Gly Asn Tyr Thr Val Ile Leu
385                 390                 395                 400 
Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val
                405                 410                 415     
Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val
            420                 425                 430         
Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr
        435                 440                 445             
Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu
    450                 455                 460                 
Glu Cys Ala Asn Glu Pro Ser Xaa Ala Val Ser Val Thr Asn Pro Tyr
465                 470                 475                 480 
Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys
                485                 490                 495     
Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys
            500                 505                 510         
Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr
        515                 520                 525             
Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser
    530                 535                 540                 
Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln
545                 550                 555                 560 
Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser
                565                 570                 575     
Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro
            580                 585                 590         
Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr
        595                 600                 605             
Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile
    610                 615                 620                 
Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr
625                 630                 635                 640 
Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val
                645                 650                 655     
Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn
            660                 665                 670         
Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys
        675                 680                 685             
Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn
    690                 695                 700                 
Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg
705                 710                 715                 720 
Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr
                725                 730                 735     
Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe
            740                 745                 750         
Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu
        755                 760                 765             
Val Gly Thr Xaa Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile
    770                 775                 780                 
Ile Leu Xaa Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly
785                 790                 795                 800 
Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His
                805                 810                 815     
Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp
            820                 825                 830         
Arg Leu Xaa Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Xaa
        835                 840                 845             
Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr
    850                 855                 860                 
Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg
865                 870                 875                 880 
Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu
                885                 890                 895     
Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu
            900                 905                 910         
Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu
        915                 920                 925             
Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg
    930                 935                 940                 
Phe Arg Gln Gly Lys Asp Tyr Xaa Gly Ala Ile Pro Val Asp Leu Lys
945                 950                 955                 960 
Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly
                965                 970                 975     
Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro
            980                 985                 990         
Glu Asp Leu Tyr Lys Asp Phe Leu Thr Leu Glu His Leu Ile Cys Tyr
        995                 1000                1005            
Ser Phe Gln Val Ala Lys Gly Met Glu Phe Leu Ala Ser Arg Lys Cys
    1010                1015                1020                
Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Ser Glu Lys Asn
1025                1030                1035                1040
Val Val Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asp
                1045                1050                1055    
Pro Asp Tyr Val Arg Lys Gly Asp Ala Arg Leu Pro Leu Lys Trp Met
            1060                1065                1070        
Ala Pro Glu Thr Ile Phe Asp Arg Val Tyr Thr Ile Gln Ser Asp Val
        1075                1080                1085            
Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Ala Ser
    1090                1095                1100                
Pro Tyr Pro Gly Val Lys Ile Asp Glu Glu Phe Cys Arg Arg Leu Lys
1105                1110                1115                1120
Glu Gly Thr Arg Met Arg Ala Pro Asp Tyr Thr Thr Pro Glu Met Tyr
                1125                1130                1135    
Gln Thr Met Leu Asp Cys Trp His Gly Glu Xaa Ser Gln Arg Pro Thr
            1140                1145                1150        
Phe Ser Glu Leu Val Glu His Leu Gly Asn Leu Leu Gln Ala Asn Ala
        1155                1160                1165            
Gln Gln Asp Gly Lys Asp Tyr Ile Val Leu Pro Ile Ser Glu Thr Leu
    1170                1175                1180                
Ser Met Glu Glu Asp Ser Gly Leu Ser Leu Pro Thr Ser Pro Val Ser
1185                1190                1195                1200
Cys Met Glu Glu Glu Glu Val Cys Asp Xaa Lys Phe His Tyr Asp Asn
                1205                1210                1215    
Thr Ala Gly Ile Ser Gln Tyr Leu Gln Asn Ser Lys Arg Lys Ser Arg
            1220                1225                1230        
Pro Val Ser Val Lys Thr Phe Glu Asp Ile Pro Leu Glu Glu Pro Glu
        1235                1240                1245            
Val Lys Val Ile Pro Asp Asp Asn Gln Thr Asp Ser Gly Met Val Leu
    1250                1255                1260                
Ala Ser Glu Glu Leu Lys Thr Leu Glu Asp Arg Thr Lys Leu Ser Pro
1265                1270                1275                1280
Ser Phe Gly Gly Met Val Pro Ser Lys Ser Arg Glu Ser Val Ala Ser
                1285                1290                1295    
Glu Gly Ser Asn Gln Thr Ser Gly Tyr Gln Ser Gly Tyr His Ser Asp
            1300                1305                1310        
Asp Thr Asp Thr Thr Val Tyr Ser Ser Glu Glu Ala Glu Leu Leu Lys
        1315                1320                1325            
Leu Ile Glu Ile Gly Val Gln Thr Gly Ser Thr Ala Gln Ile Leu Gln
    1330                1335                1340                
Pro Asp Xaa Gly Thr Thr Leu Ser Ser Pro Pro Val
1345                1350                1355    


<210> 459
<211> 1298
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 134
<223> Xaa = D or G

<220> 
<221> VARIANT        
<222> 134
<223> Xaa = D or G


<220> 
<221> VARIANT        
<222> 149
<223> Xaa = N or D

<220> 
<221> VARIANT        
<222> 494
<223> Xaa = T or A

<220> 
<221> VARIANT        
<222> 854
<223> Xaa = G or S

<220> 
<221> VARIANT        
<222> 890
<223> Xaa = Q or H

<220> 
<221> VARIANT        
<222> 915
<223> Xaa = A or P

<220> 
<221> VARIANT        
<222> 916
<223> Xaa = C or W

<220> 
<221> VARIANT        
<222> 933
<223> Xaa = G or R

<220> 
<221> VARIANT        
<222> 954
<223> Xaa = P or S

<220> 
<221> VARIANT        
<222> 1008
<223> Xaa = P or L

<220> 
<221> VARIANT        
<222> 1041
<223> Xaa = R or Q

<220> 
<221> VARIANT        
<222> 1137
<223> Xaa = P or L

<220> 
<221> VARIANT        
<222> 1164
<223> Xaa = D or E

<220> 
<221> VARIANT        
<222> 1189
<223> Xaa = R or L

<220> 
<221> VARIANT        
<222> 1324
<223> Xaa = R or L

<400> 459
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15      
Leu Leu Asp Gly Leu Val Ser Xaa Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30          
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45              
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60                  
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80  
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95      
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110         
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125             
Tyr Val Phe Val Arg Xaa Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140                 
Thr Leu Leu Val Xaa Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160 
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175     
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190         
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205             
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220                 
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240 
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255     
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270         
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285             
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300                 
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320 
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335     
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350         
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365             
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380                 
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400 
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415     
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430         
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445             
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460                 
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480 
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Xaa Gln Asp
                485                 490                 495     
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510         
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525             
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540                 
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560 
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575     
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590         
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605             
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620                 
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640 
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655     
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670         
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685             
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700                 
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720 
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735     
Arg Val Arg Glu Glu Asp Ala Gly Pro Tyr Leu Cys Ser Val Cys Arg
            740                 745                 750         
Pro Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765             
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780                 
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800 
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815     
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830         
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845             
Arg Val Leu Gly Tyr Xaa Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860                 
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880 
Leu Lys Glu Gly Ala Thr Ala Ser Glu Xaa Arg Ala Leu Met Ser Glu
                885                 890                 895     
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910         
Leu Gly Xaa Xaa Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925             
Phe Cys Lys Tyr Xaa Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940                 
Ala Phe Ser Pro Cys Ala Glu Lys Ser Xaa Glu Gln Arg Gly Arg Phe
945                 950                 955                 960 
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975     
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990         
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Xaa
        995                 1000                1005            
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020                
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Xaa Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055    
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070        
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085            
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100                
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Val Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135    
Xaa Glu Leu Ala Thr Pro Ala Ile Arg His Ile Met Leu Asn Cys Trp
            1140                1145                1150        
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Xaa Leu Val Glu Ile
        1155                1160                1165            
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180                
Cys Met Ala Pro Xaa Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215    
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230        
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245            
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260                
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295    
Phe Arg
        

<210> 460
<211> 2820
<212> DNA
<213> Homo sapiens

<300> 
<308> GenBank No. NM_000601
<309> 2005-10-18

<400> 460
gggagttcag acctagatct ttccagttaa tcacacaaca aacttagctc atcgcaataa 60
aaagcagctc agagccgact ggctctttta ggcactgact ccgaacagga ttctttcacc 120
caggcatctc ctccagaggg atccgccagc ccgtccagca gcaccatgtg ggtgaccaaa 180
ctcctgccag ccctgctgct gcagcatgtc ctcctgcatc tcctcctgct ccccatcgcc 240
atcccctatg cagagggaca aaggaaaaga agaaatacaa ttcatgaatt caaaaaatca 300
gcaaagacta ccctaatcaa aatagatcca gcactgaaga taaaaaccaa aaaagtgaat 360
actgcagacc aatgtgctaa tagatgtact aggaataaag gacttccatt cacttgcaag 420
gcttttgttt ttgataaagc aagaaaacaa tgcctctggt tccccttcaa tagcatgtca 480
agtggagtga aaaaagaatt tggccatgaa tttgacctct atgaaaacaa agactacatt 540
agaaactgca tcattggtaa aggacgcagc tacaagggaa cagtatctat cactaagagt 600
ggcatcaaat gtcagccctg gagttccatg ataccacacg aacacagctt tttgccttcg 660
agctatcggg gtaaagacct acaggaaaac tactgtcgaa atcctcgagg ggaagaaggg 720
ggaccctggt gtttcacaag caatccagag gtacgctacg aagtctgtga cattcctcag 780
tgttcagaag ttgaatgcat gacctgcaat ggggagagtt atcgaggtct catggatcat 840
acagaatcag gcaagatttg tcagcgctgg gatcatcaga caccacaccg gcacaaattc 900
ttgcctgaaa gatatcccga caagggcttt gatgataatt attgccgcaa tcccgatggc 960
cagccgaggc catggtgcta tactcttgac cctcacaccc gctgggagta ctgtgcaatt 1020
aaaacatgcg ctgacaatac tatgaatgac actgatgttc ctttggaaac aactgaatgc 1080
atccaaggtc aaggagaagg ctacaggggc actgtcaata ccatttggaa tggaattcca 1140
tgtcagcgtt gggattctca gtatcctcac gagcatgaca tgactcctga aaatttcaag 1200
tgcaaggacc tacgagaaaa ttactgccga aatccagatg ggtctgaatc accctggtgt 1260
tttaccactg atccaaacat ccgagttggc tactgctccc aaattccaaa ctgtgatatg 1320
tcacatggac aagattgtta tcgtgggaat ggcaaaaatt atatgggcaa cttatcccaa 1380
acaagatctg gactaacatg ttcaatgtgg gacaagaaca tggaagactt acatcgtcat 1440
atcttctggg aaccagatgc aagtaagctg aatgagaatt actgccgaaa tccagatgat 1500
gatgctcatg gaccctggtg ctacacggga aatccactca ttccttggga ttattgccct 1560
atttctcgtt gtgaaggtga taccacacct acaatagtca atttagacca tcccgtaata 1620
tcttgtgcca aaacgaaaca attgcgagtt gtaaatggga ttccaacacg aacaaacata 1680
ggatggatgg ttagtttgag atacagaaat aaacatatct gcggaggatc attgataaag 1740
gagagttggg ttcttactgc acgacagtgt ttcccttctc gagacttgaa agattatgaa 1800
gcttggcttg gaattcatga tgtccacgga agaggagatg agaaatgcaa acaggttctc 1860
aatgtttccc agctggtata tggccctgaa ggatcagatc tggttttaat gaagcttgcc 1920
aggcctgctg tcctggatga ttttgttagt acgattgatt tacctaatta tggatgcaca 1980
attcctgaaa agaccagttg cagtgtttat ggctggggct acactggatt gatcaactat 2040
gatggcctat tacgagtggc acatctctat ataatgggaa atgagaaatg cagccagcat 2100
catcgaggga aggtgactct gaatgagtct gaaatatgtg ctggggctga aaagattgga 2160
tcaggaccat gtgaggggga ttatggtggc ccacttgttt gtgagcaaca taaaatgaga 2220
atggttcttg gtgtcattgt tcctggtcgt ggatgtgcca ttccaaatcg tcctggtatt 2280
tttgtccgag tagcatatta tgcaaaatgg atacacaaaa ttattttaac atataaggta 2340
ccacagtcat agctgaagta agtgtgtctg aagcacccac caatacaact gtcttttaca 2400
tgaagatttc agagaatgtg gaatttaaaa tgtcacttac aacaatccta agacaactac 2460
tggagagtca tgtttgttga aattctcatt aatgtttatg ggtgttttct gttgttttgt 2520
ttgtcagtgt tattttgtca atgttgaagt gaattaaggt acatgcaagt gtaataacat 2580
atctcctgaa gatacttgaa tggattaaaa aaacacacag gtatatttgc tggatgataa 2640
agatttcatg ggaaaaaaaa tcaattaatc tgtctaagct gctttctgat gttggtttct 2700
taataatgag taaaccacaa attaaatgtt attttaacct caccaaaaca atttatacct 2760
tgtgtcccta aattgtagcc ctatattaaa ttatattaca tttcaaaaaa aaaaaaaaaa 2820


<210> 461
<211> 728
<212> PRT
<213> Homo sapiens

<300> 
<308> GenBank No. NP000592
<309> 2005-10-18

<400> 461
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu
 1               5                  10                  15      
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln
            20                  25                  30          
Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr
        35                  40                  45              
Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val
    50                  55                  60                  
Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu
65                  70                  75                  80  
Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys
                85                  90                  95      
Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe
            100                 105                 110         
Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys
        115                 120                 125             
Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys
    130                 135                 140                 
Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His
145                 150                 155                 160 
Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr
                165                 170                 175     
Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser
            180                 185                 190         
Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu
        195                 200                 205             
Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp
    210                 215                 220                 
His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro
225                 230                 235                 240 
His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp
                245                 250                 255     
Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr
            260                 265                 270         
Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys
        275                 280                 285             
Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu
    290                 295                 300                 
Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile
305                 310                 315                 320 
Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu
                325                 330                 335     
His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn
            340                 345                 350         
Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr
        355                 360                 365             
Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp
    370                 375                 380                 
Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met
385                 390                 395                 400 
Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp
                405                 410                 415     
Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala
            420                 425                 430         
Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His
        435                 440                 445             
Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys
    450                 455                 460                 
Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu
465                 470                 475                 480 
Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val
                485                 490                 495     
Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg
            500                 505                 510         
Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp
        515                 520                 525             
Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr
    530                 535                 540                 
Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu Lys
545                 550                 555                 560 
Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly
                565                 570                 575     
Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp
            580                 585                 590         
Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu
        595                 600                 605             
Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn
    610                 615                 620                 
Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu
625                 630                 635                 640 
Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu
                645                 650                 655     
Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp
            660                 665                 670         
Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val Leu
        675                 680                 685             
Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly
    690                 695                 700                 
Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile
705                 710                 715                 720 
Leu Thr Tyr Lys Val Pro Gln Ser
                725             

<210> 462
<211> 728
<212> PRT
<213> Homo sapiens

<220> 
<223> HGF sequence variants

<220> 
<221> VARIANT        
<222> 78
<223> Xaa = Lys or Asn

<220>
<221> VARIANT        
<222> 82
<223> Xaa = Phe or Leu

<220> 
<221> VARIANT        
<222> 153
<223> Xaa = Ser or Ile

<220> 
<221> VARIANT        
<222> 180
<223> Xaa = Pro or Thr

<220> 
<221> VARIANT        
<222> 293
<223> Xaa = Met or Val

<220> 
<221> VARIANT        
<222> 300
<223> Xaa = Leu or Met

<220> 
<221> VARIANT        
<222> 304
<223> Xaa = Glu or Lys

<220> 
<221> VARIANT        
<222> 317 
<223> Xaa = Val or Ala

<220> 
<221> VARIANT        
<222> 325
<223> Xaa = Pro or Ser

<220> 
<221> VARIANT        
<222> 330
<223> Xaa = Asp or Tyr

<220> 
<221> VARIANT        
<222> 336
<223> Xaa = Glu or Lys

<220> 
<221> VARIANT        
<222> 387
<223> Xaa = His or Asn

<220> 
<221> VARIANT        
<222> 416
<223> Xaa = Asp or Asn

<220> 
<221> VARIANT        
<222> 494
<223> Xaa = Arg or Gln

<220> 
<221> VARIANT        
<222> 505
<223> Xaa = Ile or Val

<220> 
<221> VARIANT        
<222> 509
<223> Xaa = Val or Ile

<220> 
<221> VARIANT        
<222> 558
<223> Xaa = Asp or Glu

<220> 
<221> VARIANT        
<222> 561
<223> Xaa = Cys or Arg

<220> 
<221> VARIANT        
<222> 592
<223> Xaa = Asp or Asn

<220> 
<221> VARIANT        
<222> 595
<223> Xaa = Ser or Asn

<400> 462
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu
 1               5                  10                  15      
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln
            20                  25                  30          
Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr
        35                  40                  45              
Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val
    50                  55                  60                  
Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Xaa Gly Leu
65                  70                  75                  80  
Pro Xaa Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys
                85                  90                  95      
Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe
            100                 105                 110         
Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys
        115                 120                 125             
Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys
    130                 135                 140                 
Ser Gly Ile Lys Cys Gln Pro Trp Xaa Ser Met Ile Pro His Glu His
145                 150                 155                 160 
Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr
                165                 170                 175     
Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser
            180                 185                 190         
Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu
        195                 200                 205             
Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp
    210                 215                 220                 
His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Xaa
225                 230                 235                 240 
His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp
                245                 250                 255     
Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr
            260                 265                 270         
Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys
        275                 280                 285             
Ala Asp Asn Thr Xaa Asn Asp Thr Asp Val Pro Xaa Glu Thr Thr Xaa
    290                 295                 300                 
Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Xaa Asn Thr Ile
305                 310                 315                 320 
Trp Asn Gly Ile Xaa Cys Gln Arg Trp Xaa Ser Gln Tyr Pro His Xaa
                325                 330                 335     
His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn
            340                 345                 350         
Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr
        355                 360                 365             
Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp
    370                 375                 380                 
Met Ser Xaa Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met
385                 390                 395                 400 
Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Xaa
                405                 410                 415     
Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala
            420                 425                 430         
Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His
        435                 440                 445             
Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys
    450                 455                 460                 
Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu
465                 470                 475                 480 
Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Xaa Val Val
                485                 490                 495     
Asn Gly Ile Pro Thr Arg Thr Asn Xaa Gly Trp Met Xaa Ser Leu Arg
            500                 505                 510         
Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp
        515                 520                 525             
Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr
    530                 535                 540                 
Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Xaa Glu Lys
545                 550                 555                 560 
Xaa Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly
                565                 570                 575     
Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp Xaa
            580                 585                 590         
Phe Val Xaa Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu
        595                 600                 605             
Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn
    610                 615                 620                 
Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu
625                 630                 635                 640 
Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu
                645                 650                 655     
Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp
            660                 665                 670         
Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val Leu
        675                 680                 685             
Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly
    690                 695                 700                 
Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile
705                 710                 715                 720 
Leu Thr Tyr Lys Val Pro Gln Ser
                725             


<210> 463
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer CSFIR_F1

<400> 463
ctgccacttc cccaccgagg                                             20

<210> 464
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer DDR1_F1

<400> 464
gggatcagga gctatgggac ca                                          22

<210> 465
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer DDR2_F1

<400> 465
ctgagatgat cctgattccc agaa                                        24

<210> 466
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHA1_F1

<400> 466
ggagctatgg agcggcgctg                                             20

<210> 467
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHA2_F1

<400> 467
agcgagaagc gcggcatgga                                             20

<210> 468
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHA3_F1

<400> 468
caccagcaac atggattgtc agc                                         23

<210> 469
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHA4_F1

<400> 469
cgaaccatgg ctgggatttt cta                                         23

<210> 470
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHA7_F1

<400> 470
ataaaacctg ctcatgcacc atg                                         23

<210> 471
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHB1_F1

<400> 471
gcgatggccc tggattatct a                                           21

<210> 472
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHB2_F1

<400> 472
ccccgggaag cgcagcca                                               18

<210> 473
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHB3_F1

<400> 473
gctcctagag ctgccacggc                                             20

<210> 474
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHB4_F1

<400> 474
gatcctaccc gagtgaggcg g                                           21

<210> 475
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer CSFIR_R1

<400> 475
gggctcctgc agagatgggt a                                           21

<210> 476
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer DDR1_R1

<400> 476
agagccattg gggacacagg ga                                          22

<210> 477
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer DDR2_R1

<400> 477
agcctgactc ctcctcccct g                                           21

<210> 478
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHA1_R1

<400> 478
agctctgtca gcaagaccct gg                                          22

<210> 479
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHA2_R1

<400> 479
aggtggtgtc tggggccagg tc                                          22

<210> 480
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHA3_R1

<400> 480
gtcaggcttg aggctactga tgg                                         23

<210> 481
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHA4_R1

<400> 481
aacataggaa gtgagagggt tcagg                                       25

<210> 482
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHA7_R1

<400> 482
actccattgg gatgctctgg ttc                                         23

<210> 483
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHB1_R1

<400> 483
agcccatcaa tccttgctgt g                                           21

<210> 484
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHB2_R1

<400> 484
gcgtgcccgc acctggaaga                                             20

<210> 485
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHB3_R1

<400> 485
gctggtcact gtggaggcga                                             20

<210> 486
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHB4_R1

<400> 486
ggtagctggc tccccgcttc a                                           21

<210> 487
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer CSFIR_R2

<400> 487
ccgagggtct taccaaactg c                                           21

<210> 488
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer DDR1_R2

<400> 488
aagcggagtc gagatcgagg ga                                          22

<210> 489
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer DDR2_R2

<400> 489
ggggaactcc tccacagcca                                             20

<210> 490
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHA1_R2

<400> 490
cgggtaaagt ccaaggctcc c                                           21

<210> 491
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHA2_R2

<400> 491
gacacaggat ggatggatct cgg                                         23

<210> 492
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHA3_R2

<400> 492
atcaatggat atgttggtgg catc                                        24

<210> 493
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHA4_R2

<400> 493
aggatgcgtc aatttctttg gca                                         23

<210> 494
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHA7_R2

<400> 494
ctgcaccaat cacacgctca a                                           21

<210> 495
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHB1_R2

<400> 495
atcaatctcc ttggcaaact cc                                          22

<210> 496
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHB2_R2

<400> 496
gcccatgatg gaggcttcgc                                             20

<210> 497
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHB3_R2

<400> 497
acgcaggaca cgtcgatctc c                                           21

<210> 498
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHB4_R2

<400> 498
acctgcacca atcacctctt caa                                         23

<210> 499
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHB6_F1

<400> 499
agagtggcgg gcatggtgtg                                             20

<210> 500
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHB6_R1

<400> 500
gcggagctga tagtccagga tg                                          22

<210> 501
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHB6_R2

<400> 501
cctgtcccaa tgacctcctc aa                                          22

<210> 502
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHA6_F1

<400> 502
ggagatgaaa gactctccat ttcaag                                      26

<210> 503
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer FGFR1_F1

<400> 503
attcgggatg tggagctgga                                             20

<210> 504
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer FGFR2_F1

<400> 504
aggaccgggg attggtaccg                                             20

<210> 505
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer FGFR3_F1

<400> 505
catgggcgcc cctgcctg                                               18

<210> 506
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer FGFR4_F1

<400> 506
agaaggagat gcggctgctg                                             20

<210> 507
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer TNFR1A(p55)_F1

<400> 507
agctgtctgg catgggcctc tc                                          22

<210> 508
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer TNFR1B(p55)_F1

<400> 508
accggacccc gcccgcac                                               18

<210> 509
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer EPHA6_R1

<400> 509
atcttagacc gacagaaaat ttggc                                       25

<210> 510
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer FGFR1_R1

<400> 510
caagggacca tcctgcgtgc                                             20

<210> 511
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer FGFR2_R1

<400> 511
aggggcttgc ccagtgtcag                                             20

<210> 512
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer FGFR3_R1

<400> 512
gctcccattt ggggtcggca                                             20

<210> 513
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer FGFR4_R1

<400> 513
cgggggaact cccatagtgg                                             20

<210> 514
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer TNFR1A(p55)_R1

<400> 514
ggcgcagcct catctgagaa ga                                          22

<210> 515
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer TNFR1B(p55)_R1

<400> 515
cacagcccac accggcctgg                                             20

<210> 516
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer FLT3_F1

<400> 516
ggaggccatg ccggcgttg                                              19

<210> 517
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer KIT-F1

<400> 517
cgcagctacc gcgatgagag g                                           21

<210> 518
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer MET_F1

<400> 518
ctcataatga aggcccccgc                                             20

<210> 519
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer PDGFRA_F1

<400> 519
aagtttccca gagctatggg ga                                          22

<210> 520
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer PDGFRB_F1

<400> 520
agcagcaagg acaccatgcg                                             20

<210> 521
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer RON_F1

<400> 521
ggtcccagct cgcctcgatg                                             20

<210> 522
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer TEK_F1

<400> 522
agatttgggg aagcatggac tc                                          22

<210> 523
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer TIE_F1

<400> 523
cggcctctgg agtatggtct g                                           21

<210> 524
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer VEGFR1_F1

<400> 524
catggtcagc tactgggaca cc                                          22

<210> 525
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer VEGFR2_F1

<400> 525
aggtgcagga tgcagagcaa g                                           21

<210> 526
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer VEGFR3_F1

<400> 526
agcggccgga gatgcagcg                                              19

<210> 527
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer FLT3_R1

<400> 527
ctgctcgaca cccactgtcc a                                           21

<210> 528
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer KIT-R1

<400> 528
gcagaagtct tgcccacatc g                                           21

<210> 529
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer MET_R1

<400> 529
cttcgtgatc ttcttcccag tga                                         23

<210> 530
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer PDGFRA_R1

<400> 530
agattcttag ccaggcatcg ca                                          22

<210> 531
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer PDGFRB_R1

<400> 531
agcgcaccga cagtggccga                                             20

<210> 532
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer RON_R1

<400> 532
gcacgggctg cccactgtca                                             20

<210> 533
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer TEK_R1

<400> 533
ctgtccgagg ttccaaatag ttga                                        24

<210> 534
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer TIE_R1

<400> 534
cgttctcact ggggtccacc a                                           21

<210> 535
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer VEGFR1_R1

<400> 535
attattgcca tgcgctgagt ga                                          22

<210> 536
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer VEGFR2_R1

<400> 536
gccgcttgga taacaagggt a                                           21

<210> 537
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer VEGFR3_R1

<400> 537
aactcggtcc aggtgtccag gc                                          22

<210> 538
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer FLT3_R2

<400> 538
cttggaaact cccatttgag atca                                        24

<210> 539
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer KIT-R2

<400> 539
acaaccttcc cgaaagctcc a                                           21

<210> 540
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer MET_R2

<400> 540
actacatgct gcactgcctg ga                                          22

<210> 541
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer PDGFRA_R2

<400> 541
cccgaccaag cactagtcca tc                                          22

<210> 542
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer PDGFRB_R2

<400> 542
ccagagccga gggtgcgtcc                                             20

<210> 543
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer RON_R2

<400> 543
caggtcattc aggttgggag ga                                          22

<210> 544
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer TEK_R2

<400> 544
atttgatgtc attccagtca agca                                        24

<210> 545
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer TIE_R2

<400> 545
agcactgggt agctcagggg c                                           21

<210> 546
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer VEGFR1_R2

<400> 546
aactcccact tgctggcatc a                                           21

<210> 547
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer VEGFR2_R2

<400> 547
aattcccatt tgctggcatc a                                           21

<210> 548
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer VEGFR3_R2

<400> 548
attcccactg gctggcatcg ta                                          22

<210> 549
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer RAGE_Fu

<400> 549
caggaccctg gaaggaagca                                             20

<210> 550
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer RAGE_F1

<400> 550
aggatggcag ccggaacag                                              19

<210> 551
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer RAGE_flR1

<400> 551
cccctcaagg ccctccagta                                             20

<210> 552
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer RAGE_Intron3R1

<400> 552
ggaagtcaga ggccctcatg g                                           21

<210> 553
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer RAGE_Intron4R1

<400> 553
gggaaagagt ggtgacctca ga                                          22

<210> 554
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer RAGE_Intron5R1

<400> 554
cttggggggc accttaggac tc                                          22

<210> 555
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer RAGE_Intron6R1

<400> 555
actccctctt tccctaaggg tca                                         23

<210> 556
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer RAGE_Intron7R1

<400> 556
gttatggttc accctacctc cca                                         23

<210> 557
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer RAGE_Intron8R1

<400> 557
atttagctca gagggaagaa ggga                                        24

<210> 558
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer HGF_F1

<400> 558
aggattcttt cacccaggca                                             20

<210> 559
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer HGF_intron11R1

<400> 559
gaataaatgc cagaccacct a                                           21

<210> 560
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer HGF_F2

<400> 560
accatgtggg tgaccaaact                                             20

<210> 561
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer HGF_intron11R2

<400> 561
tcacaagaca ccaatcccta act                                         23

<210> 562
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer HGF_intron13R1

<400> 562
tccatatttc tgggaatagg aggac                                       25

<210> 563
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide containing propeptide and linker
      segments

<400> 563
Gly Ala Arg Ser Arg
 1               5  


<210> 564
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide containing propeptide and linker
      segments

<400> 564
Gly Ala Arg Leu Glu
 1               5  

<210> 565
<211> 330
<212> PRT
<213> Homo Sapiens

<220> 
<223> hIgG1 heavy chain constant

<400> 565
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330

<210> 566
<211> 231
<212> PRT
<213> Artificial Sequence

<220> 
<223> hIgG1 Fc

<400> 566
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
 1               5                  10                  15      
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
            20                  25                  30          
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
        35                  40                  45              
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
    50                  55                  60                  
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
65                  70                  75                  80  
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
                85                  90                  95      
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
            100                 105                 110         
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
        115                 120                 125             
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
    130                 135                 140                 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
145                 150                 155                 160 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
                165                 170                 175     
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
            180                 185                 190         
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
        195                 200                 205             
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
    210                 215                 220                 
Leu Ser Leu Ser Pro Gly Lys
225                 230     


<210> 567
<211> 232
<212> PRT
<213> Artificial Sequence

<220> 
<223> hIgG1 Fc

<400> 567
Glu Pro Arg Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Asp Tyr Lys Cys Lys Val Ser Asn Lys Ala
            100                 105                 110         
Leu Pro Ala Pro Met Gln Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Arg
145                 150                 155                 160 
His Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys
225                 230         


<210> 568
<211> 232
<212> PRT
<213> Artificial Sequence

<220> 
<223> hIgG1 Fc mutein

<400> 568
Glu Pro Arg Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Asp Tyr Lys Cys Lys Val Ser Asn Lys Ala
            100                 105                 110         
Leu Pro Ala Pro Met Gln Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Arg
145                 150                 155                 160 
His Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys
225                 230         

<210> 569
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> c-jun leucine zipper

<400> 569
Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn
 1               5                  10                  15      
Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln
            20                  25                  30          
Leu Lys Gln Lys Val Met Asn
        35                  


<210> 570
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> c-fos leucine zipper

<400> 570
Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys
 1               5                  10                  15      
Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys
            20                  25                  30          
Leu Glu Phe Ile Leu Ala Ala
        35                  

<210> 571
<211> 43
<212> PRT
<213> Artificial Sequence

<220> 
<223> modified c-jun leucine zipper

<400> 571
Cys Gly Gly Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys
 1               5                  10                  15      
Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln
            20                  25                  30          
Val Ala Gln Leu Lys Gln Lys Val Met Asn Tyr
        35                  40              


<210> 572
<211> 43
<212> PRT
<213> Artificial Sequence

<220> 
<223> modified c-fos leucine zipper

<400> 572
Cys Gly Gly Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu
 1               5                  10                  15      
Asp Glu Lys Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu
            20                  25                  30          
Lys Glu Lys Leu Glu Phe Ile Leu Ala Ala Tyr
        35                  40   

<210> 573
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> GCN4 leucine zipper

<400> 573
Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn
 1               5                  10                  15      
Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Glu
            20                  25                  30          
Arg
            
<210> 574
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> GCN4 leucine zipper- trimer

<400> 574
Arg Met Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile
 1               5                  10                  15      
Tyr His Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu
            20                  25                  30          
Arg
    


<210> 575
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> GCN4 leucine zipper- tetramer

<400> 575
Arg Met Lys Gln Ile Glu Asp Lys Leu Glu Glu Ile Leu Ser Lys Leu
 1               5                  10                  15      
Tyr His Ile Glu Asn Glu Leu Ala Arg Ile Lys Lys Leu Leu Gly Glu
            20                  25                  30          
Arg
    

<210> 576
<211> 44
<212> PRT
<213> Artificial Sequence

<220> 
<223> R subunit
      

<400> 576
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr
 1               5                  10                  15      
Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala
            20                  25                  30          
Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala
        35                  40                  


<210> 577
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> AD

<400> 577
Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln
 1               5                  10                  15      
Ala
    


<210> 578
<211> 45
<212> PRT
<213> Artificial Sequence

<220> 
<223> modified R subunit
      

<400> 578
Cys Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly
 1               5                  10                  15      
Tyr Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe
            20                  25                  30          
Ala Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala
        35                  40                  45  


<210> 579
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> modified AD subunit
      

<400> 579
Cys Gly Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile
 1               5                  10                  15      
Gln Gln Ala Gly Cys
            20   

<210> 580
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker

<400> 580
Gly Gly Gly Gly Ser
 1               5 

<210> 581
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker
      
<400> 581
Ser Ser Ser Ser Gly
 1               5        

<210> 582
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker

<400> 582
Gly Gly Gly Gly Gly
1               5        

<210> 583
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> DCPT forward primer

<400> 583
gagagggctc tgctgtgtgc tg                                          22

<210> 584
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> DCPT reverse primer

<400> 584
gtattgttca gcgggtctcc                                             20

<210> 585
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> GAPDH forward primer

<400> 585
atgaggtcca ccctgtt                                                17

<210> 586
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> GAPDH reverse primer

<400> 586
catggaggag gctggggctc                                             20

<210> 587
<211> 2700
<212> DNA
<213> Artificial Sequence

<220> 
<223> SR020H07b	MET

<400> 587
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga gtgtaaagag gcactagcaa agtccgagat gaatgtgaat 180
atgaagtatc agcttcccaa cttcaccgcg gaaacaccca tccagaatgt cattctacat 240
gagcatcaca ttttccttgg tgccactaac tacatttatg ttttaaatga ggaagacctt 300
cagaaggttg ctgagtacaa gactgggcct gtgctggaac acccagattg tttcccatgt 360
caggactgca gcagcaaagc caatttatca ggaggtgttt ggaaagataa catcaacatg 420
gctctagttg tcgacaccta ctatgatgat caactcatta gctgtggcag cgtcaacaga 480
gggacctgcc agcgacatgt ctttccccgc aatcatactg ctgacataca gtcggaggtt 540
cactgcatat tctccccaca gatagaagag cccagccagt gtcctgactg tgtggtgagc 600
gccctgggag ccaaagtcct ttcatctgta aaggaccggt tcaccaactt ctttgtaggc 660
aataccataa attcttctta tttcccagat catccattgc attcgatatc agtgagaagg 720
ctaaaggaaa cgaaagatgg ttttatgttt ttgacggacc agtcctacat tgatgtttta 780
cctgagttca gagattctta ccccattaag tatgtccatg cctttgaaag caacaatttt 840
atttacttct tgacggtcca aagggaaact ctagatgctc agacttttca cacaagaata 900
atcaggttct gttccataaa ctctggattg cattcctaca tggaaatgcc tctggagtgt 960
attctcacag aaaagagaaa aaagagatcc acaaagaagg aagtgtttaa tatacttcag 1020
gctgcgtatg tcagcaagcc tggggcccag cttgctagac aaataggagc cagcccgaat 1080
gatgacattc ttttcggagt gttcgcacaa agcaagccag attctgccga accaatggat 1140
cgatctgcca tgtgtgcatt ccctatcaaa tatgtcaacg acttcttcaa caagatcgtc 1200
aacaaaaaca atgtgagatg tctccagcat ttttacggac ccaatcatga gcactgcttt 1260
aataggacac ttctgagaaa ttcatcaggc tgtgaagcgc gccgtgatga atatcgaaca 1320
gagttcacca cagctttgca gcgcgttgac ttattcatgg gtcaattcag cgaagtcctc 1380
ttaacatcta tatccacctt cattaaagga gacctcacca tagctaatct tgggacatca 1440
gagggtcgct tcatgcaggt tgtggtttct cgatcaggac catcaacccc tcatgtgaat 1500
tttctcctgg actcccatcc agtgtctcca gaagtgattg tggagcatac attaaaccaa 1560
aatggctaca cactggttat cactgggaag aagatcacga agatcccatt gaatggcttg 1620
ggctgcagac atttccagtc ctgcagtcaa tgcctctctg ccccaccctt tgttcagtgt 1680
ggctggtgcc acgacaaatg tgtgcgatcg gaggaatgcc tgagcgggac atggactcaa 1740
cagatctgtc tgcctgcaat ctacaaggtt ttcccaaata gtgcacccct tgaaggaggg 1800
acaaggctga ccatatgtgg ctgggacttt ggatttcgga ggaataataa atttgattta 1860
aagaaaacta gagttctcct tggaaatgag agctgcacct tgactttaag tgagagcacg 1920
atgaatacat tgaaatgcac agttggtcct gccatgaata agcatttcaa tatgtccata 1980
attatttcaa atggccacgg gacaacacaa tacagtacat tctcctatgt ggatcctgta 2040
ataacaagta tttcgccgaa atacggtcct atggctggtg gcactttact tactttaact 2100
ggaaattacc taaacagtgg gaattctaga cacatttcaa ttggtggaaa aacatgtact 2160
ttaaaaagtg tgtcaaacag tattcttgaa tgttataccc cagcccaaac catttcaact 2220
gagtttgctg ttaaattgaa aattgactta gccaaccgag agacaagcat cttcagttac 2280
cgtgaagatc ccattgtcta tgaaattcat ccaaccaaat cttttattag tggtgggagc 2340
acaataacag gtgttgggaa aaacctgaat tcagttagtg tcccgagaat ggtcataaat 2400
gtgcatgaag cgggaaggaa ctttacagtg gcatgtcaac atcgctctaa ttcagagata 2460
atctgttgta ccactccttc cctgcaacag ctgaatctgc aactccccct gaaaaccaaa 2520
gcctttttca tgttagatgg gatcctttcc aaatactttg atctcattta tgtacataat 2580
cctgtgttta agccttttga aaagccagtg atgatctcaa tgggcaatga aaatgtactg 2640
gaaattaagg taagaaatgc tttaaacact gtcttaaatc atcagctcaa acttaattga 2700


<210> 588
<211> 1266
<212> DNA
<213> Artificial Sequence

<220> 
<223> SR022D06b	FGFR2

<400> 588
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga gccctccttc agtttagttg aggataccac attagagcca 180
gaagagccac caaccaaata ccaaatctct caaccagaag tgtacgtggc tgcgccaggg 240
gagtcgctag aggtgcgctg cctgttgaaa gatgccgccg tgatcagttg gactaaggat 300
ggggtgcact tggggcccaa caataggaca gtgcttattg gggagtactt gcagataaag 360
ggcgccacgc ctagagactc cggcctctat gcttgtactg ccagtaggac tgtagacagt 420
gaaacttggt acttcatggt gaatgtcaca gatgccatct catccggaga tgatgaggat 480
gacaccgatg gtgcggaaga ttttgtcagt gagaacagta acaacaagag agcaccatac 540
tggaccaaca cagaaaagac ggaaaagcgg ctccatgctg tgcctgcggc caacactgtc 600
aagtttcgct gcccagccgg ggggaaccca atgccaacca tgcggtggct gaaaaacggg 660
aaggagttta agcaggagca tcgcattgga ggctacaagg tacgaaacca gcactggagc 720
ctcattatgg aaagtgtggt cccatctgac aagggaaatt atacctgtgt ggtggagaat 780
gaatacgggt ccatcaatca cacgtaccac ctggatgttg tggagcgatc gcctcaccgg 840
cccatcctcc aagccggact gccggcaaat gcctccacag tggtcggagg agacgtagag 900
tttgtctgca aggtttacag tgatgcccag ccccacatcc agtggatcaa gcacgtggaa 960
aagaacggca gtaaatacgg gcccgacggg ctgccctacc tcaaggttct caaggccgcc 1020
ggtgttaaca ccacggacaa agagattgag gttctctata ttcggaatgt aacttttgag 1080
gacgctgggg aatatacgtg cttggcgggt aattctattg ggatatcctt tcactctgca 1140
tggttgacag ttctgccagg tatatactgt tctttctctc tgggtttttt tcccttttct 1200
tggttgactg ctataaaatt aacacagctt ctgttatcag aaatggcccc ttttatcctt 1260
gcataa                                                            1266

<210> 589
<211> 1689
<212> DNA
<213> Artificial Sequence

<220> 
<223> SR018C02b	VEGFR1

<400> 589
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga gtcaaaatta aaagatcctg aactgagttt aaaaggcacc 180
cagcacatca tgcaagcagg ccagacactg catctccaat gcagggggga agcagcccat 240
aaatggtctt tgcctgaaat ggtgagtaag gaaagcgaaa ggctgagcat aactaaatct 300
gcctgtggaa gaaatggcaa acaattctgc agtactttaa ccttgaacac agctcaagca 360
aaccacactg gcttctacag ctgcaaatat ctagctgtac ctacttcaaa gaagaaggaa 420
acagaatctg caatctatat atttattagt gatacaggta gacctttcgt agagatgtac 480
agtgaaatcc ccgaaattat acacatgact gaaggaaggg agctcgtcat tccctgccgg 540
gttacgtcac ctaacatcac tgttacttta aaaaagtttc cacttgacac tttgatccct 600
gatggaaaac gcataatctg ggacagtaga aagggcttca tcatatcaaa tgcaacgtac 660
aaagaaatag ggcttctgac ctgtgaagca acagtcaatg ggcatttgta taagacaaac 720
tatctcacac atcgacaaac caatacaatc atagatgtcc aaataagcac accacgccca 780
gtcaaattac ttagaggcca tactcttgtc ctcaattgta ctgctaccac tcccttgaac 840
acgagagttc aaatgacctg gagttaccct gatgaaaaaa ataagagagc ttccgtaagg 900
cgacgaattg accaaagcaa ttcccatgcc aacatattct acagtgttct tactattgac 960
aaaatgcaga acaaagacaa aggactttat acttgtcgtg taaggagtgg accatcattc 1020
aaatctgtta acacctcagt gcatatatat gataaagcat tcatcactgt gaaacatcga 1080
aaacagcagg tgcttgaaac cgtagctggc aagcggtctt accggctctc tatgaaagtg 1140
aaggcatttc cctcgccgga agttgtatgg ttaaaagatg ggttacctgc gactgagaaa 1200
tctgctcgct atttgactcg tggctactcg ttaattatca aggacgtaac tgaagaggat 1260
gcagggaatt atacaatctt gctgagcata aaacagtcaa atgtgtttaa aaacctcact 1320
gccactctaa ttgtcaatgt gaaaccccag atttacgaaa aggccgtgtc atcgtttcca 1380
gacccggctc tctacccact gggcagcaga caaatcctga cttgtaccgc atatggtatc 1440
cctcaaccta caatcaagtg gttctggcac ccctgtaacc ataatcattc cgaagcaagg 1500
tgtgactttt gttccaataa tgaagagtcc tttatcctgg atgctgacag caacatggga 1560
aacagaattg agagcatcac tcagcgcatg gcaataatag aaggaaagaa taagcttcca 1620
ccagctaaca gttctttcat gttgccacct acaagcttct cttccaacta cttccatttc 1680
cttccgtga                                                         1689

<210> 590
<211> 1053
<212> DNA
<213> Artificial Sequence

<220> 
<223> SR007C09b	PDGFRb

<400> 590
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga ggtcgtcaca cccccggggc cagagcttgt cctcaatgtc 180
tccagcacct tcgttctgac ctgctcgggt tcagctccgg tggtgtggga acggatgtcc 240
caggagcccc cacaggaaat ggccaaggcc caggatggca ccttctccag cgtgctcaca 300
ctgaccaacc tcactgggct agacacggga gaatactttt gcacccacaa tgactcccgt 360
ggactggaga ccgatgagcg gaaacggctc tacatctttg tgccagatcc caccgtgggc 420
ttcctcccta atgatgccga ggaactattc atctttctca cggaaataac tgagatcacc 480
attccatgcc gagtaacaga cccacagctg gtggtgacac tgcacgagaa gaaaggggac 540
gttgcactgc ctgtccccta tgatcaccaa cgtggctttt ctggtatctt tgaggacaga 600
agctacatct gcaaaaccac cattggggac agggaggtgg attctgatgc ctactatgtc 660
tacagactcc aggtgtcatc catcaacgtc tctgtgaacg cagtgcagac tgtggtccgc 720
cagggtgaga acatcaccct catgtgcatt gtgatcggga atgaggtggt caacttcgag 780
tggacatacc cccgcaaagg aagtgggcgg ctggtggagc cggtgactga cttcctcttg 840
gatatgcctt accacatccg ctccatcctg cacatcccca gtgccgagtt agaagactcg 900
gggacctaca cctgcaatgt gtcggagagt gtgaatgacc atcaggatga aaaggccatc 960
aacatcaccg tgagagcggc tacgtgcggc tcctgggaga ggtgggcaca ctacaatttg 1020
ctgagctgca tcggagccgg acactgcagg tag                              1053

<210> 591
<211> 939
<212> DNA
<213> Artificial Sequence

<220> 
<223> SR005A06b	CSF1R

<400> 591
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga gccagtgata gagcccagtg tccccgagct ggtcgtgaag 180
ccaggagcaa cggtgacctt gcgatgtgtg ggcaatggca gcgtggaatg ggatggcccc 240
ccatcacctc actggaccct gtactctgat ggctccagca gcatcctcag caccaacaac 300
gctaccttcc aaaacacggg gacctatcgc tgcactgagc ctggagaccc cctgggaggc 360
agcgccgcca tccacctcta tgtcaaagac cctgcccggc cctggaacgt gctagcacag 420
gaggtggtcg tgttcgagga ccaggacgca ctactgccct gtctgctcac agacccggtg 480
ctggaagcag gcgtctcgct ggtgcgtgtg cgtggccggc ccctcatgcg ccacaccaac 540
tactccttct cgccctggca tggcttcacc atccacaggg ccaagttcat tcaaagccag 600
gactatcaat gcagtgccct gatgggtggc aggaaggtga tgtccatcag catccggctg 660
aaagtgcaga aagtcatccc agggccccca gccttgacac tggtgcctgc agagctggtg 720
cggattcgag gggaggctgc ccagatcgtg tgctcagcca gcagcgttga tgttaacttt 780
gatgtcttcc tccaacacaa caacactaag ctcgcaatcc ctcaacaatc tgactttcat 840
aataaccgtt accaaaacag caacgtgcag ggcaagcact ccacctccat gttcttccgg 900
gtggtaggca caccttcacc ctctctctgc cccgcctga                        939

<210> 592
<211> 1236
<212> DNA
<213> Artificial Sequence

<220> 
<223> SR021C06b	RAGE

<400> 592
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga gcaaaacatc acagcccgga ttggcgagcc actggtgctg 180
aagtgtaagg gggcccccaa gaaaccaccc cagcggctgg aatggaaact gaacacaggc 240
cggacagaag cttggaaggt cctgtctccc cagggaggag gcccctggga cagtgtggct 300
cgtgtccttc ccaacggctc cctcttcctt ccggctgtcg ggatccagga tgaggggatt 360
ttccggtgcc aggcaatgaa caggaatgga aaggagacca agtccaacta ccgagtccgt 420
gtctaccaga ttcctgggaa gccagaaatt gtagattctg cctctgaact cacggctggt 480
gttcccaata aggtggggac atgtgtgtcg gagggaagct accctgcagg gactcttagc 540
tggcacttgg atgggaagcc cctggtgcct aatgagaagg gagtatctgt gaaggaacag 600
accaggagac accctgagac agggctcttc acactgcagt cggagctaat ggtgacccca 660
gcccggggag gagatccccg tcccaccttc tcctgtagct tcagcccagg ccttccccga 720
caccgggcct tgcgcacagc ccccatccag ccccgtgtct gggagcctgt gcctctggag 780
gaggtccaat tggtggtgga gccagaaggt ggagcagtag ctcctggtgg aaccgtaacc 840
ctgacctgtg aagtccctgc ccagccctct cctcaaatcc actggatgaa ggatggggtg 900
cccttgcccc ttccccccag ccctgtgctg atcctccctg agatagggcc tcaggaccag 960
ggaacctaca gctgtgtggc cacccattcc agccacgggc cccaggaaag ccgtgctgtc 1020
agcatcagca tcatcggtga gacctctccc caagccctac agaccctggg actagggtgc 1080
aggacagcac aggctctaat ttcctgcccc attctggcct tatccctaac agccacccca 1140
cctctccctc catgcaccca cacccaagcc tcccctgccc cacccaaatt ctgccaagag 1200
agcagccaag cctctccctt cttccctctg agctaa                           1236

<210> 593
<211> 1038
<212> DNA
<213> Artificial Sequence

<220> 
<223> SR022C02b	FGFR1

<400> 593
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga gccgtccccg accttgcctg aacaagatgc tctcccctcc 180
tcggaggatg atgatgatga tgatgactcc tcttcagagg agaaagaaac agataacacc 240
aaaccaaacc gtatgcccgt agctccatat tggacatccc cagaaaagat ggaaaagaaa 300
ttgcatgcag tgccggctgc caagacagtg aagttcaaat gcccttccag tgggacccca 360
aaccccacac tgcgctggtt ggaaaatggc aaagaattca aacctggcca cagaattgga 420
ggctacaagg tccgttatgc cacctggagc atcataatgg actctgtggt gccctctgac 480
aagggcaact acacctgcat tgtggagaat gagtacggca gcatcaacca cacataccag 540
ctggatgtcg tggagcggtc ccctcaccgg cccatcctgc aagcagggtt gcccgccaac 600
aaaacagtgg ccctgggtag caacgtggag ttcatgtgta aggtgtacag tgacccgcag 660
ccgcacatcc agtggctaaa gcacatcgag gtgaatggga gcaagattgg cccggacaac 720
ctgccttatg tccagatctt gaagactgct ggagttaata ccaccgacaa agagatggag 780
gtgcttcact taagaaatgt ctcctttgag gacgcagggg agtatacgtg cttggcgggt 840
aactctatcg gactctccca tcactctgca tggttgaccg ttctggaagg tacacactgt 900
aacttctcct ctcgatgtcc tgccctcgcc acgggcacgg ggggagcatg catttccagg 960
cttggggaga cacagaggca ggagagctgg aagaatgggc tcctgcctgc ctggtgccac 1020
atcctgcccc agctttga                                               1038

<210> 594
<211> 1314
<212> DNA
<213> Artificial Sequence

<220> 
<223> SR002H01b	KIT

<400> 594
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga gtcttctcaa ccatctgtga gtccagggga accgtctcca 180
ccatccatcc atccaggaaa atcagactta atagtccgcg tgggcgacga gattaggctg 240
ttatgcactg atccgggctt tgtcaaatgg acttttgaga tcctggatga aacgaatgag 300
aataagcaga atgaatggat cacggaaaag gcagaagcca ccaacaccgg caaatacacg 360
tgcaccaaca aacacggctt aagcaattcc atttatgtgt ttgttagaga tcctgccaag 420
cttttccttg ttgaccgctc cttgtatggg aaagaagaca acgacacgct ggtccgctgt 480
cctctcacag acccagaagt gaccaattat tccctcaagg ggtgccaggg gaagcctctt 540
cccaaggact tgaggtttat tcctgacccc aaggcgggca tcatgatcaa aagtgtgaaa 600
cgcgcctacc atcggctctg tctgcattgt tctgtggacc aggagggcaa gtcagtgctg 660
tcggaaaaat tcatcctgaa agtgaggcca gccttcaaag ctgtgcctgt tgtgtctgtg 720
tccaaagcaa gctatcttct tagggaaggg gaagaattca cagtgacgtg cacaataaaa 780
gatgtgtcta gttctgtgta ctcaacgtgg aaaagagaaa acagtcagac taaactacag 840
gagaaatata atagctggca tcacggtgac ttcaattatg aacgtcaggc aacgttgact 900
atcagttcag cgagagttaa tgattctgga gtgttcatgt gttatgccaa taatactttt 960
ggatcagcaa atgtcacaac aaccttggaa gtagtagata aaggattcat taatatcttc 1020
cccatgataa acactacagt atttgtaaac gatggagaaa atgtagattt gattgttgaa 1080
tatgaagcat tccccaaacc tgaacaccag cagtggatct atatgaacag aaccttcact 1140
gataaatggg aagattatcc caagtctgag aatgaaagta atatcagata cgtaagtgaa 1200
cttcatctaa cgagattaaa aggcaccgaa gggggcactt acacattcct agtgtccaat 1260
tctgacgtca atgctgccat agcatttaat gtttatgtga atacttccct gtaa       1314

<210> 595
<211> 1326
<212> DNA
<213> Artificial Sequence

<220> 
<223> DPCT Construct

<400> 595
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagatctag acaccaccat 120
catcaccatc accatcaagt gtgcaccggc acagacatga agctgcggct ccctgccagt 180
cccgagaccc acctggacat gctccgccac ctctaccagg gctgccaggt ggtgcaggga 240
aacctggaac tcacctacct gcccaccaat gccagcctgt ccttcctgca ggatatccag 300
gaggtgcagg gctacgtgct catcgctcac aaccaagtga ggcaggtccc actgcagagg 360
ctgcggattg tgcgaggcac ccagctcttt gaggacaact atgccctggc cgtgctagac 420
aatggagacc cgctgaacaa taccacccct gtcacagggg cctccccagg aggcctgcgg 480
gagctgcagc ttcgaagcct cacagagatc ttgaaaggag gggtcttgat ccagcggaac 540
ccccagctct gctaccagga cacgattttg tggaaggaca tcttccacaa gaacaaccag 600
ctggctctca cactgataga caccaaccgc tctcgggcct gccacccctg ttctccgatg 660
tgtaagggct cccgctgctg gggagagagt tctgaggatt gtcagagcct gacgcgcact 720
gtctgtgccg gtggctgtgc ccgctgcaag gggccactgc ccactgactg ctgccatgag 780
cagtgtgctg ccggctgcac gggccccaag cactctgact gcctggcctg cctccacttc 840
aaccacagtg gcatctgtga gctgcactgc ccagccctgg tcacctacaa cacagacacg 900
tttgagtcca tgcccaatcc cgagggccgg tatacattcg gcgccagctg tgtgactgcc 960
tgtccctaca actacctttc tacggacgtg ggatcctgca ccctcgtctg ccccctgcac 1020
aaccaagagg tgacagcaga ggatggaaca cagcggtgtg agaagtgcag caagccctgt 1080
gcccgaggta cccactcact gcccccgagg ccagctgcag ttcctgtccc tctgcgcatg 1140
cagcctggcc cagcccaccc tgtcctatcc ttcctcagac cctcttggga cctagtctct 1200
gccttctact ctctacccct ggcccccctc agccctacaa gtgtccctat atcccctgtc 1260
agtgtgggga ggggcccgga ccctgatgct catgtggctg ttgacctgtc ccggtatgaa 1320
ggctga                                                            1326

<210> 596
<211> 2139
<212> DNA
<213> Artificial Sequence

<220> 
<223> SR015F01b	VEGFR2

<400> 596
atgcagagca aggtgctgct ggccgtcgcc ctgtggctct gcgtggagac ccgggccgcc 60
tctgtgggtt tgcctagtgt ttctcttgat ctgcccaggc tcagcataca aaaagacata 120
cttacaatta aggctaatac aactcttcaa attacttgca ggggacagag ggacttggac 180
tggctttggc ccaataatca gagtggcagt gagcaaaggg tggaggtgac tgagtgcagc 240
gatggcctct tctgtaagac actcacaatt ccaaaagtga tcggaaatga cactggagcc 300
tacaagtgct tctaccggga aactgacttg gcctcggtca tttatgtcta tgttcaagat 360
tacagatctc catttattgc ttctgttagt gaccaacatg gagtcgtgta cattactgag 420
aacaaaaaca aaactgtggt gattccatgt ctcgggtcca tttcaaatct caacgtgtca 480
ctttgtgcaa gatacccaga aaagagattt gttcctgatg gtaacagaat ttcctgggac 540
agcaagaagg gctttactat tcccagctac atgatcagct atgctggcat ggtcttctgt 600
gaagcaaaaa ttaatgatga aagttaccag tctattatgt acatagttgt cgttgtaggg 660
tataggattt atgatgtggt tctgagtccg tctcatggaa ttgaactatc tgttggagaa 720
aagcttgtct taaattgtac agcaagaact gaactaaatg tggggattga cttcaactgg 780
gaataccctt cttcgaagca tcagcataag aaacttgtaa accgagacct aaaaacccag 840
tctgggagtg agatgaagaa atttttgagc accttaacta tagatggtgt aacccggagt 900
gaccaaggat tgtacacctg tgcagcatcc agtgggctga tgaccaagaa gaacagcaca 960
tttgtcaggg tccatgaaaa accttttgtt gcttttggaa gtggcatgga atctctggtg 1020
gaagccacgg tgggggagcg tgtcagaatc cctgcgaagt accttggtta cccaccccca 1080
gaaataaaat ggtataaaaa tggaataccc cttgagtcca atcacacaat taaagcgggg 1140
catgtactga cgattatgga agtgagtgaa agagacacag gaaattacac tgtcatcctt 1200
accaatccca tttcaaagga gaagcagagc catgtggtct ctctggttgt gtatgtccca 1260
ccccagattg gtgagaaatc tctaatctct cctgtggatt cctaccagta cggcaccact 1320
caaacgctga catgtacggt ctatgccatt cctcccccgc atcacatcca ctggtattgg 1380
cagttggagg aagagtgcgc caacgagccc agccaagctg tctcagtgac aaacccatac 1440
ccttgtgaag aatggagaag tgtggaggac ttccagggag gaaataaaat tgaagttaat 1500
aaaaatcaat ttgctctaat tgaaggaaaa aacaaaactg taagtaccct tgttatccaa 1560
gcggcaaatg tgtcagcttt gtacaaatgt gaagcggtca acaaagtcgg gagaggagag 1620
agggtgatct ccttccacgt gaccaggggt cctgaaatta ctttgcaacc tgacatgcag 1680
cccactgagc aggagagcgt gtctttgtgg tgcactgcag acagatctac gtttgagaac 1740
ctcacatggt acaagcttgg cccacagcct ctgccaatcc atgtgggaga gttgcccaca 1800
cctgtttgca agaacttgga tactctttgg aaattgaatg ccaccatgtt ctctaatagc 1860
acaaatgaca ttttgatcat ggagcttaag aatgcatcct tgcaggacca aggagactat 1920
gtctgccttg ctcaagacag gaagaccaag aaaagacatt gcgtggtcag gcagctcaca 1980
gtcctagagc gtgtggcacc cacgatcaca ggaaacctgg agaatcagac gacaagtatt 2040
ggggaaagca tcgaagtctc atgcacggca tctgggaatc cccctccaca gatcatgtgg 2100
tttaaagata atgagaccct tgtagaagac tcagagtga                        2139

<210> 597
<211> 2298
<212> DNA
<213> Artificial Sequence

<220> 
<223> SR015G09b	VEGFR3

<400> 597
atgcagcggg gcgccgcgct gtgcctgcga ctgtggctct gcctgggact cctggacggc 60
ctggtgagtg gctactccat gacccccccg accttgaaca tcacggagga gtcacacgtc 120
atcgacaccg gtgacagcct gtccatctcc tgcaggggac agcaccccct cgagtgggct 180
tggccaggag ctcaggaggc gccagccacc ggagacaagg acagcgagga cacgggggtg 240
gtgcgagact gcgagggcac agacgccagg ccctactgca aggtgttgct gctgcacgag 300
gtacatgcca acgacacagg cagctacgtc tgctactaca agtacatcaa ggcacgcatc 360
gagggcacca cggccgccag ctcctacgtg ttcgtgagag actttgagca gccattcatc 420
aacaagcctg acacgctctt ggtcaacagg aaggacgcca tgtgggtgcc ctgtctggtg 480
tccatccccg gcctcaatgt cacgctgcgc tcgcaaagct cggtgctgtg gccagacggg 540
caggaggtgg tgtgggatga ccggcggggc atgctcgtgt ccacgccact gctgcacgat 600
gccctgtacc tgcagtgcga gaccacctgg ggagaccagg acttcctttc caaccccttc 660
ctggtgcaca tcacaggcaa cgagctctat gacatccagc tgttgcccag gaagtcgctg 720
gagctgctgg taggggagaa gctggtcctg aactgcaccg tgtgggctga gtttaactca 780
ggtgtcacct ttgactggga ctacccaggg aagcaggcag agcggggtaa gtgggtgccc 840
gagcgacgct cccagcagac ccacacagaa ctctccagca tcctgaccat ccacaacgtc 900
agccagcacg acctgggctc gtatgtgtgc aaggccaaca acggcatcca gcgatttcgg 960
gagagcaccg aggtcattgt gcatgaaaat cccttcatca gcgtcgagtg gctcaaagga 1020
cccatcctgg aggccacggc aggagacgag ctggtgaagc tgcccgtgaa gctggcagcg 1080
taccccccgc ccgagttcca gtggtacaag gatggaaagg cactgtccgg gcgccacagt 1140
ccacatgccc tggtgctcaa ggaggtgaca gaggccagca caggcaccta caccctcgcc 1200
ctgtggaact ccgctgctgg cctgaggcgc aacatcagcc tggagctggt ggtgaatgtg 1260
cccccccaga tacatgagaa ggaggcctcc tcccccagca tctactcgcg tcacagccgc 1320
caggccctca cctgcacggc ctacggggtg cccctgcctc tcagcatcca gtggcactgg 1380
cggccctgga caccctgcaa gatgtttgcc cagcgtagtc tccggcggcg gcagcagcaa 1440
gacctcatgc cacagtgccg tgactggagg gcggtgacca cgcaggatgc cgtgaacccc 1500
atcgagagcc tggacacctg gaccgagttt gtggagggaa agaataagac tgtgagcaag 1560
ctggtgatcc agaatgccaa cgtgtctgcc atgtacaagt gtgtggtctc caacaaggtg 1620
ggccaggatg agcggctcat ctacttctat gtgaccacca tccccgacgg cttcaccatc 1680
gaatccaagc catccgagga gctactagag ggccagccgg tgctcctgag ctgccaagcc 1740
gacagctaca agtacgagca tctgcgctgg taccgcctca acctgtccac gctgcacgat 1800
gcgcacggga acccgcttct gctcgactgc aagaacgtgc atctgttcgc cacccctctg 1860
gccgccagcc tggaggaggt ggcacctggg gcgcgccacg ccacgctcag cctgagtatc 1920
ccccgcgtcg cgcccgagca cgagggccac tatgtgtgcg aagtgcaaga ccggcgcagc 1980
catgacaagc actgccacaa gaagtacctg tcggtgcagg ccctggaagc ccctcggctc 2040
acgcagaact tgaccgacct cctggtgaac gtgagcgact cgctggagat gcagtgcttg 2100
gtggccggag cgcacgcgcc cagcatcgtg tggtacaaag acgagaggct gctggaggaa 2160
aagtctggta gggagggtgg ccctggcgaa gggcaggtcc ggaggcccgc gaggccgacg 2220
atcccaaacc caggtggacc cgcacctcca ccccaccccc tgcaggagtc gacttggcgg 2280
actccaacca gaagctga                                               2298

<210> 598
<211> 1563
<212> DNA
<213> Artificial Sequence

<220> 
<223> SR016E12b	EPHA2

<400> 598
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga gcagggcaag gaagtggtac tgctggactt tgctgcagct 180
ggaggggagc tcggctggct cacacacccg tatggcaaag ggtgggacct gatgcagaac 240
atcatgaatg acatgccgat ctacatgtac tccgtgtgca acgtgatgtc tggcgaccag 300
gacaactggc tccgcaccaa ctgggtgtac cgaggagagg ctgagcgtat cttcattgag 360
ctcaagttta ctgtacgtga ctgcaacagc ttccctggtg gcgccagctc ctgcaaggag 420
actttcaacc tctactatgc cgagtcggac ctggactacg gcaccaactt ccagaagcgc 480
ctgttcacca agattgacac cattgcgccc gatgagatca ccgtcagcag cgacttcgag 540
gcacgccacg tgaagctgaa cgtggaggag cgctccgtgg ggccgctcac ccgcaaaggc 600
ttctacctgg ccttccagga tatcggtgcc tgtgtggcac tactctccgt ccgtgtctac 660
tacgagaagt gccccgagcc gctgcagggc ctggcccact tccctgagac catcgccggc 720
tctgatgcac cttccctggc cactgtggcc ggcacctgtg tggaccatgc cgtggtgcca 780
ccggggggtg aagagccccg tatgcactgt gcagtggatg gcgagtggct ggtgcccatt 840
gggcagtgcc tgtgccaggc aggctacgag aaggtggagg atgcctgcca ggcctgctcg 900
cctggatttt ttaagtttga ggcatccgag agcccctgct tggagtgccc tgagcgcacg 960
ctgccatccc ctgagggtgc cacctcctgc gagtgtgagg aaggcttctt ccgggcacct 1020
caggacccag cgtcgatgcc ttgcacacga cccccttccg ccccacacta cctcacagcc 1080
gtgggcatgg gtgccaaggt ggagctgcgc tggacgcccc ctcaggacag cgggggccgc 1140
gaggacattg tctacagcgt cacctgcgaa cagtgctggc ccgagtctgg ggaatgcggg 1200
ccgtgtgagg ccagtgtgcg ctactcggag cctcctcacg gactgacccg caccagtgtg 1260
acagtgagcg acctggagcc ccacatgaac tacaccttca ccgtggaggc ccgcaatggc 1320
gtctcaggcc tggtaaccag ccgcagcttc cgtactgcca gtgtcagcat caaccagaca 1380
gagcccccca aggtgaggct ggagggccgc agcaccacct cgcttagcgt ctcctggagc 1440
atccccccgc cgcagcagag ccgagtgtgg aagtacgagg tcacttaccg caagaaggta 1500
actcccagag gggcggggct ggctctagct gggccgacag caggggacag gctggtcaca 1560
tag                                                               1563

<210> 599
<211> 2010
<212> DNA
<213> Artificial Sequence

<220> 
<223> SR014E12b	RON

<400> 599
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga ggactggcag tgcccgcgca ccccctacgc ggcctctcgc 180
gactttgacg tgaagtacgt ggtgcccagc ttctccgccg gaggcctggt acaggccatg 240
gtgacctacg agggcgacag aaatgagagt gctgtgtttg tagccatacg caatcgcctg 300
catgtgcttg ggcctgacct gaagtctgtc cagagcctgg ccacgggccc tgctggagac 360
cctggctgcc agacgtgtgc agcctgtggc ccaggacccc acggccctcc cggtgacaca 420
gacacaaagg tgctggtgct ggatcccgcg ctgcctgcgc tggtcagttg tggctccagc 480
ctgcagggcc gctgcttcct gcatgaccta gagccccaag ggacagccgt gcatctggca 540
gcgccagcct gcctcttctc agcccaccat aaccggcccg atgactgccc cgactgtgtg 600
gccagcccat tgggcacccg tgtaactgtg gttgagcaag gccaggcctc ctatttctac 660
gcggcatcct cactggacgc agccgtggct gccagcttca gcccacgctc agtgtctatc 720
aggcgtctca aggctgacgc ctcgggattc gcaccgggct ttgtgacgtt gtcagtgctg 780
cccaagcatc ttgtctccta cagtattgaa tacgtgcaca gcttccacac gggagccttc 840
gtatacttcc tgactgtaca gccggccagc gtgacagatg atcctagtgc cctgcacaca 900
cgcctggcac ggcttagcgc cactgagcca gagttgggtg actatcggga gctggtcctc 960
gactgcagat ttgctccaaa acgcaggcgc cggggggccc cagaaggcgg acagccctac 1020
cctgtgctgc gggtggccca ctccgctcca gtgggtgccc aacttgccac tgagctgagc 1080
atcgccgagg gccaggaagt actatttggg gtctttgtga ctggcaagga tggtggtcct 1140
ggcgtgggcc ccaactctgt cgtctgtgcc ttccccattg acctgctgga cacactaatt 1200
gatgagggtg tggagcgctg ttgtgaatcc ccagtccatc caggcctccg gcgaggcctc 1260
gacttcttcc agtcgcccag tttttgcccc aacccgcctg gcctggaagc cctcagcccc 1320
aacaccagct gccgccactt ccctctgctg gtcagtagca gcttctcacg tgtggaccta 1380
ttcaatgggc tgttgggacc agtacaggtc actgcattgt atgtgacacg ccttgacaac 1440
gtcacagtgg cacacatggg cacaatggat gggcgtatcc tgcaggtgga gctggtcagg 1500
tcactaaact acttgctgta tgtgtccaac ttctcactgg gtgacagtgg gcagcccgtg 1560
cagcgggatg tcagtcgtct tggggaccac ctactctttg cctctgggga ccaggttttc 1620
caggtaccta tccgaggccc tggctgccgc cacttcctga cctgtgggcg ttgcctaagg 1680
gcatggcatt tcatgggctg tggctggtgt gggaacgtgt gcggccagca gaaggagtgt 1740
cctggctcct ggcaacagga ccactgccca cctaagctta ctgagttcca cccccacagt 1800
ggacctctaa ggggcagtac aaggctgacc ctgtgtggct ccaacttcta ccttcaccct 1860
tctggtctgg tgcctgaggg aacccatcag gtcactgtgg gccaaagtcc ctgccggcca 1920
ctgcccaagg acagctcaaa actcaggtac aatctggtcc ctcccctccc tttccctgaa 1980
gggggaaacc aagcagcccc ttccccatga                                  2010

<210> 600
<211> 1407
<212> DNA
<213> Artificial Sequence

<220> 
<223> SR002A10b	FGFR4

<400> 600
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga ggaggaagtg gagcttgagc cctgcctggc tcccagcctg 180
gagcagcaag agcaggagct gacagtagcc cttgggcagc ctgtgcggct gtgctgtggg 240
cgggctgagc gtggtggcca ctggtacaag gagggcagtc gcctggcacc tgctggccgt 300
gtacggggct ggaggggccg cctagagatt gccagcttcc tacctgagga tgctggccgc 360
tacctctgcc tggcacgagg ctccatgatc gtcctgcaga atctcacctt gattacaggt 420
gactccttga cctccagcaa cgatgatgag gaccccaagt cccataggga cccctcgaat 480
aggcacagtt acccccagca agcaccctac tggacacacc cccagcgcat ggagaagaaa 540
ctgcatgcag tacctgcggg gaacaccgtc aagttccgct gtccagctgc aggcaacccc 600
acgcccacca tccgctggct taaggatgga caggcctttc atggggagaa ccgcattgga 660
ggcattcggc tgcgccatca gcactggagt ctcgtgatgg agagcgtggt gccctcggac 720
cgcggcacat acacctgcct ggtagagaac gctgtgggca gcatctgcta taactacctg 780
ctagatgtgc tggagcggtc cccgcaccgg cccatcctgc aggccgggct cccggccaac 840
accacagccg tggtgggcag cgacgtggag ctgctgtgca aggtgtacag cgatgcccag 900
ccccacatcc agtggctgaa gcacatcgtc atcaacggca gcagcttcgg agccgacggt 960
ttcccctatg tgcaagtcct aaagactgca gacatcaata gctcagaggt ggaggtcctg 1020
tacctgcgga acgtgtcagc cgaggacgca ggcgagtaca cctgcctcgc aggcaattcc 1080
atcggcctct cctaccagtc tgcctggctc acggtgctgc caggtgagca cctgaagggc 1140
caggagatgc tgcgagatgc ccctctgggc cagcagtggg ggctgtggcc tgttgggtgg 1200
tcagtctctg ttggcctgtg gggtctggcc tggggggcag tgtgtggatt tgtgggtttg 1260
agctgtatga cagcccctct gtgcctctcc acacgtggcc gtccatgtga ccgtctgctg 1320
aggtgtgggt gcctgggact gggcataact acagcttcct ccgtgtgtgt ccccacatat 1380
gttgggagct gggagggact gagttag                                     1407

<210> 601
<211> 1188
<212> DNA
<213> Artificial Sequence

<220> 
<223> SR007G02b	TIE-2

<400> 601
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt 60
tcgcccagcc aggaaatcca tgcccgattc agaagaggag ccagagaaca aaaactcatc 120
tcagaagagg atctgctcga ggtggaaggt gccatggact tgatcttgat caattcccta 180
cctcttgtat ctgatgctga aacatctctc acctgcattg cctctgggtg gcgcccccat 240
gagcccatca ccataggaag ggactttgaa gccttaatga accagcacca ggatccgctg 300
gaagttactc aagatgtgac cagagaatgg gctaaaaaag ttgtttggaa gagagaaaag 360
gctagtaaga tcaatggtgc ttatttctgt gaagggcgag ttcgaggaga ggcaatcagg 420
atacgaacca tgaagatgcg tcaacaagct tccttcctac cagctacttt aactatgact 480
gtggacaagg gagatcacgt gaacatatct ttcaaaaagg tattgattaa agaagaagat 540
gcagcgattt acaaaaatgg ttccttcatc cattcagtgc cccggcatga agtacctgat 600
attctagaag tacacctgcc tcatgctcag ccccaggatg ctggagtgta ctcggccagg 660
tatgtaggag gaaacctctt cacctcggcc ttcaccaggc tgatagtccg gagatgtgaa 720
gcccagaagt ggggacctga atgcaaccat ctctgtactg cttgtatgaa caatggtgtc 780
tgccatgaag atactggaga atgcatttgc cctcctgggt ttatgggaag gacgtgtgag 840
aaggcttgtg aactgcacac gtttggcaga acttgtaaag aaaggtgcag tggacaagag 900
ggatgcaagt cttatgtgtt ctgtctccct gacccctatg ggtgttcctg tgccgcaggc 960
tggaagggtc tgcagtgcaa tgaagcatgc caccctggtt tttacgggcc agattgtaag 1020
cttaggtgca gctgcaacaa tggggagatg tgtgatcgct tccaaggatg tctctgctct 1080
ccaggatggc aggggctcca gtgtgagaga gaaggtaaag caaggcatac cgaggatgac 1140
cccaaagata gtggatttgc cagatcatat agaagtaaac agtggtaa              1188

<210> 602
<211> 2256
<212> DNA
<213> Artificial Sequence

<220> 
<223> SR016G03b	TIE-1

<400> 602
atggtctggc gggtgccccc tttcttgctc cccatcctct tcttggcttc tcatgtgggc 60
gcggcggtgg acctgacgct gctggccaac ctgcggctca cggaccccca gcgcttcttc 120
ctgacttgcg tgtctgggga ggccggggcg gggaggggct cggacgcctg gggcccgccc 180
ctgctgctgg agaaggacga ccgtatcgtg cgcaccccgc ccgggccacc cctgcgcctg 240
gcgcgcaacg gttcgcacca ggtcacgctt cgcggcttct ccaagccctc ggacctcgtg 300
ggcgtcttct cctgcgtggg cggtgctggg gcgcggcgca cgcgcgtcat ctacgtgcac 360
aacagccctg gagcccacct gcttccagac aaggtcacac acactgtgaa caaaggtgac 420
accgctgtac tttctgcacg tgtgcacaag gagaagcaga cagacgtgat ctggaagagc 480
aacggatcct acttctacac cctggactgg catgaagccc aggatgggcg gttcctgctg 540
cagctcccaa atgtgcagcc accatcgagc ggcatctaca gtgccactta cctggaagcc 600
agccccctgg gcagcgcctt ctttcggctc atcgtgcggg gttgtggggc tgggcgctgg 660
gggccaggct gtaccaagga gtgcccaggt tgcctacatg gaggtgtctg ccacgaccat 720
gacggcgaat gtgtatgccc ccctggcttc actggcaccc gctgtgaaca ggcctgcaga 780
gagggccgtt ttgggcagag ctgccaggag cagtgcccag gcatatcagg ctgccggggc 840
ctcaccttct gcctcccaga cccctatggc tgctcttgtg gatctggctg gagaggaagc 900
cagtgccaag aagcttgtgc ccctggtcat tttggggctg attgccgact ccagtgccag 960
tgtcagaatg gtggcacttg tgaccggttc agtggttgtg tctgcccctc tgggtggcat 1020
ggagtgcact gtgagaagtc agaccggatc ccccagatcc tcaacatggc ctcagaactg 1080
gagttcaact tagagacgat gccccggatc aactgtgcag ctgcagggaa ccccttcccc 1140
gtgcggggca gcatagagct acgcaagcca gacggcactg tgctcctgtc caccaaggcc 1200
attgtggagc cagagaagac cacagctgag ttcgaggtgc cccgcttggt tcttgcggac 1260
agtgggttct gggagtgccg tgtgtccaca tctggcggcc aagacagccg gcgcttcaag 1320
gtcaatgtga aagtgccccc cgtgcccctg gctgcacctc ggctcctgac caagcagagc 1380
cgccagcttg tggtctcccc gctggtctcg ttctctgggg atggacccat ctccactgtc 1440
cgcctgcact accggcccca ggacagtacc atggactggt cgaccattgt ggtggacccc 1500
agtgagaacg tgacgttaat gaacctgagg ccaaagacag gatacagtgt tcgtgtgcag 1560
ctgagccggc caggggaagg aggagagggg gcctgggggc ctcccaccct catgaccaca 1620
gactgtcctg agcctttgtt gcagccgtgg ttggagggct ggcatgtgga aggcactgac 1680
cggctgcgag tgagctggtc cttgcccttg gtgcccgggc cactggtggg cgacggtttc 1740
ctgctgcgcc tgtgggacgg gacacggggg caggagcggc gggagaacgt ctcatccccc 1800
caggcccgca ctgccctcct gacgggactc acgcctggca cccactacca gctggatgtg 1860
cagctctacc actgcaccct cctgggcccg gcctcgcccc ctgcacacgt gcttctgccc 1920
cccagtgggc ctccagcccc ccgacacctc cacgcccagg ccctctcaga ctccgagatc 1980
cagctgacat ggaagcaccc ggaggctctg cctgggccaa tatccaagta cgttgtggag 2040
gtgcaggtgg ctgggggtgc aggagaccca ctgtggatag acgtggacag gcctgaggag 2100
acaagcacca tcatccgtgg cctcaacgcc agcacgcgct acctcttccg catgcgggcc 2160
agcattcagg ggctcgggga ctggagcaac acagtagaag agtccaccct gggcaacggt 2220
gagagggcag ggcccacagg accccccggg ctctga                           2256

<210> 603
<211> 899
<212> PRT
<213> Artificial Sequence

<220> 
<223> SR020H07b	MET

<400> 603
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Cys
        35                  40                  45              
Lys Glu Ala Leu Ala Lys Ser Glu Met Asn Val Asn Met Lys Tyr Gln
    50                  55                  60                  
Leu Pro Asn Phe Thr Ala Glu Thr Pro Ile Gln Asn Val Ile Leu His
65                  70                  75                  80  
Glu His His Ile Phe Leu Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn
                85                  90                  95      
Glu Glu Asp Leu Gln Lys Val Ala Glu Tyr Lys Thr Gly Pro Val Leu
            100                 105                 110         
Glu His Pro Asp Cys Phe Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn
        115                 120                 125             
Leu Ser Gly Gly Val Trp Lys Asp Asn Ile Asn Met Ala Leu Val Val
    130                 135                 140                 
Asp Thr Tyr Tyr Asp Asp Gln Leu Ile Ser Cys Gly Ser Val Asn Arg
145                 150                 155                 160 
Gly Thr Cys Gln Arg His Val Phe Pro Arg Asn His Thr Ala Asp Ile
                165                 170                 175     
Gln Ser Glu Val His Cys Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser
            180                 185                 190         
Gln Cys Pro Asp Cys Val Val Ser Ala Leu Gly Ala Lys Val Leu Ser
        195                 200                 205             
Ser Val Lys Asp Arg Phe Thr Asn Phe Phe Val Gly Asn Thr Ile Asn
    210                 215                 220                 
Ser Ser Tyr Phe Pro Asp His Pro Leu His Ser Ile Ser Val Arg Arg
225                 230                 235                 240 
Leu Lys Glu Thr Lys Asp Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr
                245                 250                 255     
Ile Asp Val Leu Pro Glu Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val
            260                 265                 270         
His Ala Phe Glu Ser Asn Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg
        275                 280                 285             
Glu Thr Leu Asp Ala Gln Thr Phe His Thr Arg Ile Ile Arg Phe Cys
    290                 295                 300                 
Ser Ile Asn Ser Gly Leu His Ser Tyr Met Glu Met Pro Leu Glu Cys
305                 310                 315                 320 
Ile Leu Thr Glu Lys Arg Lys Lys Arg Ser Thr Lys Lys Glu Val Phe
                325                 330                 335     
Asn Ile Leu Gln Ala Ala Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala
            340                 345                 350         
Arg Gln Ile Gly Ala Ser Pro Asn Asp Asp Ile Leu Phe Gly Val Phe
        355                 360                 365             
Ala Gln Ser Lys Pro Asp Ser Ala Glu Pro Met Asp Arg Ser Ala Met
    370                 375                 380                 
Cys Ala Phe Pro Ile Lys Tyr Val Asn Asp Phe Phe Asn Lys Ile Val
385                 390                 395                 400 
Asn Lys Asn Asn Val Arg Cys Leu Gln His Phe Tyr Gly Pro Asn His
                405                 410                 415     
Glu His Cys Phe Asn Arg Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu
            420                 425                 430         
Ala Arg Arg Asp Glu Tyr Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg
        435                 440                 445             
Val Asp Leu Phe Met Gly Gln Phe Ser Glu Val Leu Leu Thr Ser Ile
    450                 455                 460                 
Ser Thr Phe Ile Lys Gly Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser
465                 470                 475                 480 
Glu Gly Arg Phe Met Gln Val Val Val Ser Arg Ser Gly Pro Ser Thr
                485                 490                 495     
Pro His Val Asn Phe Leu Leu Asp Ser His Pro Val Ser Pro Glu Val
            500                 505                 510         
Ile Val Glu His Thr Leu Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr
        515                 520                 525             
Gly Lys Lys Ile Thr Lys Ile Pro Leu Asn Gly Leu Gly Cys Arg His
    530                 535                 540                 
Phe Gln Ser Cys Ser Gln Cys Leu Ser Ala Pro Pro Phe Val Gln Cys
545                 550                 555                 560 
Gly Trp Cys His Asp Lys Cys Val Arg Ser Glu Glu Cys Leu Ser Gly
                565                 570                 575     
Thr Trp Thr Gln Gln Ile Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro
            580                 585                 590         
Asn Ser Ala Pro Leu Glu Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp
        595                 600                 605             
Asp Phe Gly Phe Arg Arg Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg
    610                 615                 620                 
Val Leu Leu Gly Asn Glu Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr
625                 630                 635                 640 
Met Asn Thr Leu Lys Cys Thr Val Gly Pro Ala Met Asn Lys His Phe
                645                 650                 655     
Asn Met Ser Ile Ile Ile Ser Asn Gly His Gly Thr Thr Gln Tyr Ser
            660                 665                 670         
Thr Phe Ser Tyr Val Asp Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr
        675                 680                 685             
Gly Pro Met Ala Gly Gly Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu
    690                 695                 700                 
Asn Ser Gly Asn Ser Arg His Ile Ser Ile Gly Gly Lys Thr Cys Thr
705                 710                 715                 720 
Leu Lys Ser Val Ser Asn Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln
                725                 730                 735     
Thr Ile Ser Thr Glu Phe Ala Val Lys Leu Lys Ile Asp Leu Ala Asn
            740                 745                 750         
Arg Glu Thr Ser Ile Phe Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu
        755                 760                 765             
Ile His Pro Thr Lys Ser Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly
    770                 775                 780                 
Val Gly Lys Asn Leu Asn Ser Val Ser Val Pro Arg Met Val Ile Asn
785                 790                 795                 800 
Val His Glu Ala Gly Arg Asn Phe Thr Val Ala Cys Gln His Arg Ser
                805                 810                 815     
Asn Ser Glu Ile Ile Cys Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn
            820                 825                 830         
Leu Gln Leu Pro Leu Lys Thr Lys Ala Phe Phe Met Leu Asp Gly Ile
        835                 840                 845             
Leu Ser Lys Tyr Phe Asp Leu Ile Tyr Val His Asn Pro Val Phe Lys
    850                 855                 860                 
Pro Phe Glu Lys Pro Val Met Ile Ser Met Gly Asn Glu Asn Val Leu
865                 870                 875                 880 
Glu Ile Lys Val Arg Asn Ala Leu Asn Thr Val Leu Asn His Gln Leu
                885                 890                 895     
Lys Leu Asn
            


<210> 604
<211> 421
<212> PRT
<213> Artificial Sequence

<220> 
<223> SR022D06b	FGFR2

<400> 604
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Pro
        35                  40                  45              
Ser Phe Ser Leu Val Glu Asp Thr Thr Leu Glu Pro Glu Glu Pro Pro
    50                  55                  60                  
Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val Tyr Val Ala Ala Pro Gly
65                  70                  75                  80  
Glu Ser Leu Glu Val Arg Cys Leu Leu Lys Asp Ala Ala Val Ile Ser
                85                  90                  95      
Trp Thr Lys Asp Gly Val His Leu Gly Pro Asn Asn Arg Thr Val Leu
            100                 105                 110         
Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala Thr Pro Arg Asp Ser Gly
        115                 120                 125             
Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val Asp Ser Glu Thr Trp Tyr
    130                 135                 140                 
Phe Met Val Asn Val Thr Asp Ala Ile Ser Ser Gly Asp Asp Glu Asp
145                 150                 155                 160 
Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn Asn Lys
                165                 170                 175     
Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Thr Glu Lys Arg Leu His
            180                 185                 190         
Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala Gly Gly
        195                 200                 205             
Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys
    210                 215                 220                 
Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His Trp Ser
225                 230                 235                 240 
Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys
                245                 250                 255     
Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His Leu Asp
            260                 265                 270         
Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro
        275                 280                 285             
Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val Cys Lys
    290                 295                 300                 
Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His Val Glu
305                 310                 315                 320 
Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val
                325                 330                 335     
Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys Glu Ile Glu Val Leu
            340                 345                 350         
Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu
        355                 360                 365             
Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu Thr Val
    370                 375                 380                 
Leu Pro Gly Ile Tyr Cys Ser Phe Ser Leu Gly Phe Phe Pro Phe Ser
385                 390                 395                 400 
Trp Leu Thr Ala Ile Lys Leu Thr Gln Leu Leu Leu Ser Glu Met Ala
                405                 410                 415     
Pro Phe Ile Leu Ala
            420     


<210> 605
<211> 562
<212> PRT
<213> Artificial Sequence

<220> 
<223> SR018C02b	VEGFR1

<400> 605
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Ser
        35                  40                  45              
Lys Leu Lys Asp Pro Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met
    50                  55                  60                  
Gln Ala Gly Gln Thr Leu His Leu Gln Cys Arg Gly Glu Ala Ala His
65                  70                  75                  80  
Lys Trp Ser Leu Pro Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser
                85                  90                  95      
Ile Thr Lys Ser Ala Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr
            100                 105                 110         
Leu Thr Leu Asn Thr Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys
        115                 120                 125             
Lys Tyr Leu Ala Val Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala
    130                 135                 140                 
Ile Tyr Ile Phe Ile Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr
145                 150                 155                 160 
Ser Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val
                165                 170                 175     
Ile Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys
            180                 185                 190         
Phe Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp
        195                 200                 205             
Ser Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly
    210                 215                 220                 
Leu Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn
225                 230                 235                 240 
Tyr Leu Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser
                245                 250                 255     
Thr Pro Arg Pro Val Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn
            260                 265                 270         
Cys Thr Ala Thr Thr Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser
        275                 280                 285             
Tyr Pro Asp Glu Lys Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp
    290                 295                 300                 
Gln Ser Asn Ser His Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp
305                 310                 315                 320 
Lys Met Gln Asn Lys Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser
                325                 330                 335     
Gly Pro Ser Phe Lys Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys
            340                 345                 350         
Ala Phe Ile Thr Val Lys His Arg Lys Gln Gln Val Leu Glu Thr Val
        355                 360                 365             
Ala Gly Lys Arg Ser Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro
    370                 375                 380                 
Ser Pro Glu Val Val Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys
385                 390                 395                 400 
Ser Ala Arg Tyr Leu Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val
                405                 410                 415     
Thr Glu Glu Asp Ala Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln
            420                 425                 430         
Ser Asn Val Phe Lys Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys
        435                 440                 445             
Pro Gln Ile Tyr Glu Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu
    450                 455                 460                 
Tyr Pro Leu Gly Ser Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile
465                 470                 475                 480 
Pro Gln Pro Thr Ile Lys Trp Phe Trp His Pro Cys Asn His Asn His
                485                 490                 495     
Ser Glu Ala Arg Cys Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile
            500                 505                 510         
Leu Asp Ala Asp Ser Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln
        515                 520                 525             
Arg Met Ala Ile Ile Glu Gly Lys Asn Lys Leu Pro Pro Ala Asn Ser
    530                 535                 540                 
Ser Phe Met Leu Pro Pro Thr Ser Phe Ser Ser Asn Tyr Phe His Phe
545                 550                 555                 560 
Leu Pro
        


<210> 606
<211> 350
<212> PRT
<213> Artificial Sequence

<220> 
<223> SR007C09b	PDGFRb

<400> 606
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Val
        35                  40                  45              
Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser Thr Phe
    50                  55                  60                  
Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg Met Ser
65                  70                  75                  80  
Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr Phe Ser
                85                  90                  95      
Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly Glu Tyr
            100                 105                 110         
Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu Arg Lys
        115                 120                 125             
Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu Pro Asn
    130                 135                 140                 
Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu Ile Thr
145                 150                 155                 160 
Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu His Glu
                165                 170                 175     
Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln Arg Gly
            180                 185                 190         
Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr Thr Ile
        195                 200                 205             
Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg Leu Gln
    210                 215                 220                 
Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val Val Arg
225                 230                 235                 240 
Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn Glu Val
                245                 250                 255     
Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Gly Ser Gly Arg Leu Val
            260                 265                 270         
Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile Arg Ser
        275                 280                 285             
Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr Tyr Thr
    290                 295                 300                 
Cys Asn Val Ser Glu Ser Val Asn Asp His Gln Asp Glu Lys Ala Ile
305                 310                 315                 320 
Asn Ile Thr Val Arg Ala Ala Thr Cys Gly Ser Trp Glu Arg Trp Ala
                325                 330                 335     
His Tyr Asn Leu Leu Ser Cys Ile Gly Ala Gly His Cys Arg
            340                 345                 350 


<210> 607
<211> 312
<212> PRT
<213> Artificial Sequence

<220> 
<223> SR005A06b	CSF1R

<400> 607
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Pro
        35                  40                  45              
Val Ile Glu Pro Ser Val Pro Glu Leu Val Val Lys Pro Gly Ala Thr
    50                  55                  60                  
Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val Glu Trp Asp Gly Pro
65                  70                  75                  80  
Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly Ser Ser Ser Ile Leu
                85                  90                  95      
Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly Thr Tyr Arg Cys Thr
            100                 105                 110         
Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala Ile His Leu Tyr Val
        115                 120                 125             
Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala Gln Glu Val Val Val
    130                 135                 140                 
Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu Leu Thr Asp Pro Val
145                 150                 155                 160 
Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg Gly Arg Pro Leu Met
                165                 170                 175     
Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His Gly Phe Thr Ile His
            180                 185                 190         
Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln Cys Ser Ala Leu Met
        195                 200                 205             
Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg Leu Lys Val Gln Lys
    210                 215                 220                 
Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val Pro Ala Glu Leu Val
225                 230                 235                 240 
Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys Ser Ala Ser Ser Val
                245                 250                 255     
Asp Val Asn Phe Asp Val Phe Leu Gln His Asn Asn Thr Lys Leu Ala
            260                 265                 270         
Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg Tyr Gln Asn Ser Asn
        275                 280                 285             
Val Gln Gly Lys His Ser Thr Ser Met Phe Phe Arg Val Val Gly Thr
    290                 295                 300                 
Pro Ser Pro Ser Leu Cys Pro Ala
305                 310         


<210> 608
<211> 411
<212> PRT
<213> Artificial Sequence

<220> 
<223> SR021C06b	RAGE

<400> 608
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Gln
        35                  40                  45              
Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys Lys Gly
    50                  55                  60                  
Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn Thr Gly
65                  70                  75                  80  
Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly Pro Trp
                85                  90                  95      
Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu Pro Ala
            100                 105                 110         
Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met Asn Arg
        115                 120                 125             
Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr Gln Ile
    130                 135                 140                 
Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr Ala Gly
145                 150                 155                 160 
Val Pro Asn Lys Val Gly Thr Cys Val Ser Glu Gly Ser Tyr Pro Ala
                165                 170                 175     
Gly Thr Leu Ser Trp His Leu Asp Gly Lys Pro Leu Val Pro Asn Glu
            180                 185                 190         
Lys Gly Val Ser Val Lys Glu Gln Thr Arg Arg His Pro Glu Thr Gly
        195                 200                 205             
Leu Phe Thr Leu Gln Ser Glu Leu Met Val Thr Pro Ala Arg Gly Gly
    210                 215                 220                 
Asp Pro Arg Pro Thr Phe Ser Cys Ser Phe Ser Pro Gly Leu Pro Arg
225                 230                 235                 240 
His Arg Ala Leu Arg Thr Ala Pro Ile Gln Pro Arg Val Trp Glu Pro
                245                 250                 255     
Val Pro Leu Glu Glu Val Gln Leu Val Val Glu Pro Glu Gly Gly Ala
            260                 265                 270         
Val Ala Pro Gly Gly Thr Val Thr Leu Thr Cys Glu Val Pro Ala Gln
        275                 280                 285             
Pro Ser Pro Gln Ile His Trp Met Lys Asp Gly Val Pro Leu Pro Leu
    290                 295                 300                 
Pro Pro Ser Pro Val Leu Ile Leu Pro Glu Ile Gly Pro Gln Asp Gln
305                 310                 315                 320 
Gly Thr Tyr Ser Cys Val Ala Thr His Ser Ser His Gly Pro Gln Glu
                325                 330                 335     
Ser Arg Ala Val Ser Ile Ser Ile Ile Gly Glu Thr Ser Pro Gln Ala
            340                 345                 350         
Leu Gln Thr Leu Gly Leu Gly Cys Arg Thr Ala Gln Ala Leu Ile Ser
        355                 360                 365             
Cys Pro Ile Leu Ala Leu Ser Leu Thr Ala Thr Pro Pro Leu Pro Pro
    370                 375                 380                 
Cys Thr His Thr Gln Ala Ser Pro Ala Pro Pro Lys Phe Cys Gln Glu
385                 390                 395                 400 
Ser Ser Gln Ala Ser Pro Phe Phe Pro Leu Ser
                405                 410     


<210> 609
<211> 345
<212> PRT
<213> Artificial Sequence

<220> 
<223> SR022C02b	FGFR1

<400> 609
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Pro
        35                  40                  45              
Ser Pro Thr Leu Pro Glu Gln Asp Ala Leu Pro Ser Ser Glu Asp Asp
    50                  55                  60                  
Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr
65                  70                  75                  80  
Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys
                85                  90                  95      
Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe
            100                 105                 110         
Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Glu
        115                 120                 125             
Asn Gly Lys Glu Phe Lys Pro Gly His Arg Ile Gly Gly Tyr Lys Val
    130                 135                 140                 
Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp
145                 150                 155                 160 
Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn
                165                 170                 175     
His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile
            180                 185                 190         
Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn
        195                 200                 205             
Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln
    210                 215                 220                 
Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn
225                 230                 235                 240 
Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp
                245                 250                 255     
Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala
            260                 265                 270         
Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His
        275                 280                 285             
Ser Ala Trp Leu Thr Val Leu Glu Gly Thr His Cys Asn Phe Ser Ser
    290                 295                 300                 
Arg Cys Pro Ala Leu Ala Thr Gly Thr Gly Gly Ala Cys Ile Ser Arg
305                 310                 315                 320 
Leu Gly Glu Thr Gln Arg Gln Glu Ser Trp Lys Asn Gly Leu Leu Pro
                325                 330                 335     
Ala Trp Cys His Ile Leu Pro Gln Leu
            340                 345 


<210> 610
<211> 437
<212> PRT
<213> Artificial Sequence

<220> 
<223> SR002H01b	KIT

<400> 610
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Ser
        35                  40                  45              
Ser Gln Pro Ser Val Ser Pro Gly Glu Pro Ser Pro Pro Ser Ile His
    50                  55                  60                  
Pro Gly Lys Ser Asp Leu Ile Val Arg Val Gly Asp Glu Ile Arg Leu
65                  70                  75                  80  
Leu Cys Thr Asp Pro Gly Phe Val Lys Trp Thr Phe Glu Ile Leu Asp
                85                  90                  95      
Glu Thr Asn Glu Asn Lys Gln Asn Glu Trp Ile Thr Glu Lys Ala Glu
            100                 105                 110         
Ala Thr Asn Thr Gly Lys Tyr Thr Cys Thr Asn Lys His Gly Leu Ser
        115                 120                 125             
Asn Ser Ile Tyr Val Phe Val Arg Asp Pro Ala Lys Leu Phe Leu Val
    130                 135                 140                 
Asp Arg Ser Leu Tyr Gly Lys Glu Asp Asn Asp Thr Leu Val Arg Cys
145                 150                 155                 160 
Pro Leu Thr Asp Pro Glu Val Thr Asn Tyr Ser Leu Lys Gly Cys Gln
                165                 170                 175     
Gly Lys Pro Leu Pro Lys Asp Leu Arg Phe Ile Pro Asp Pro Lys Ala
            180                 185                 190         
Gly Ile Met Ile Lys Ser Val Lys Arg Ala Tyr His Arg Leu Cys Leu
        195                 200                 205             
His Cys Ser Val Asp Gln Glu Gly Lys Ser Val Leu Ser Glu Lys Phe
    210                 215                 220                 
Ile Leu Lys Val Arg Pro Ala Phe Lys Ala Val Pro Val Val Ser Val
225                 230                 235                 240 
Ser Lys Ala Ser Tyr Leu Leu Arg Glu Gly Glu Glu Phe Thr Val Thr
                245                 250                 255     
Cys Thr Ile Lys Asp Val Ser Ser Ser Val Tyr Ser Thr Trp Lys Arg
            260                 265                 270         
Glu Asn Ser Gln Thr Lys Leu Gln Glu Lys Tyr Asn Ser Trp His His
        275                 280                 285             
Gly Asp Phe Asn Tyr Glu Arg Gln Ala Thr Leu Thr Ile Ser Ser Ala
    290                 295                 300                 
Arg Val Asn Asp Ser Gly Val Phe Met Cys Tyr Ala Asn Asn Thr Phe
305                 310                 315                 320 
Gly Ser Ala Asn Val Thr Thr Thr Leu Glu Val Val Asp Lys Gly Phe
                325                 330                 335     
Ile Asn Ile Phe Pro Met Ile Asn Thr Thr Val Phe Val Asn Asp Gly
            340                 345                 350         
Glu Asn Val Asp Leu Ile Val Glu Tyr Glu Ala Phe Pro Lys Pro Glu
        355                 360                 365             
His Gln Gln Trp Ile Tyr Met Asn Arg Thr Phe Thr Asp Lys Trp Glu
    370                 375                 380                 
Asp Tyr Pro Lys Ser Glu Asn Glu Ser Asn Ile Arg Tyr Val Ser Glu
385                 390                 395                 400 
Leu His Leu Thr Arg Leu Lys Gly Thr Glu Gly Gly Thr Tyr Thr Phe
                405                 410                 415     
Leu Val Ser Asn Ser Asp Val Asn Ala Ala Ile Ala Phe Asn Val Tyr
            420                 425                 430         
Val Asn Thr Ser Leu
        435         


<210> 611
<211> 441
<212> PRT
<213> Artificial Sequence

<220> 
<223> DCPT

<400> 611
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Ser Arg His His His His His His His His Gln Val Cys
        35                  40                  45              
Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His
    50                  55                  60                  
Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly
65                  70                  75                  80  
Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu
                85                  90                  95      
Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln
            100                 105                 110         
Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln
        115                 120                 125             
Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro
    130                 135                 140                 
Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg
145                 150                 155                 160 
Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu
                165                 170                 175     
Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys
            180                 185                 190         
Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr
        195                 200                 205             
Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser
    210                 215                 220                 
Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr
225                 230                 235                 240 
Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp
                245                 250                 255     
Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser
            260                 265                 270         
Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu
        275                 280                 285             
His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met
    290                 295                 300                 
Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala
305                 310                 315                 320 
Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val
                325                 330                 335     
Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg
            340                 345                 350         
Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Gly Thr His Ser Leu Pro
        355                 360                 365             
Pro Arg Pro Ala Ala Val Pro Val Pro Leu Arg Met Gln Pro Gly Pro
    370                 375                 380                 
Ala His Pro Val Leu Ser Phe Leu Arg Pro Ser Trp Asp Leu Val Ser
385                 390                 395                 400 
Ala Phe Tyr Ser Leu Pro Leu Ala Pro Leu Ser Pro Thr Ser Val Pro
                405                 410                 415     
Ile Ser Pro Val Ser Val Gly Arg Gly Pro Asp Pro Asp Ala His Val
            420                 425                 430         
Ala Val Asp Leu Ser Arg Tyr Glu Gly
        435                 440     


<210> 612
<211> 712
<212> PRT
<213> Artificial Sequence

<220> 
<223> SR015F01b	VEGFR2

<400> 612
Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu
 1               5                  10                  15      
Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro
            20                  25                  30          
Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr
        35                  40                  45              
Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro
    50                  55                  60                  
Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser
65                  70                  75                  80  
Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn
                85                  90                  95      
Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser
            100                 105                 110         
Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser
        115                 120                 125             
Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys
    130                 135                 140                 
Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser
145                 150                 155                 160 
Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg
                165                 170                 175     
Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile
            180                 185                 190         
Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser
        195                 200                 205             
Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr
    210                 215                 220                 
Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu
225                 230                 235                 240 
Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile
                245                 250                 255     
Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu
            260                 265                 270         
Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe
        275                 280                 285             
Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu
    290                 295                 300                 
Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr
305                 310                 315                 320 
Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met
                325                 330                 335     
Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala
            340                 345                 350         
Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly
        355                 360                 365             
Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr
    370                 375                 380                 
Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu
385                 390                 395                 400 
Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val
                405                 410                 415     
Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val
            420                 425                 430         
Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr
        435                 440                 445             
Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu
    450                 455                 460                 
Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr
465                 470                 475                 480 
Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys
                485                 490                 495     
Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys
            500                 505                 510         
Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr
        515                 520                 525             
Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser
    530                 535                 540                 
Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln
545                 550                 555                 560 
Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser
                565                 570                 575     
Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro
            580                 585                 590         
Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr
        595                 600                 605             
Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile
    610                 615                 620                 
Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr
625                 630                 635                 640 
Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val
                645                 650                 655     
Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn
            660                 665                 670         
Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys
        675                 680                 685             
Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn
    690                 695                 700                 
Glu Thr Leu Val Glu Asp Ser Glu
705                 710         


<210> 613
<211> 765
<212> PRT
<213> Artificial Sequence

<220> 
<223> SR015G09b	VEGFR3

<400> 613
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15      
Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30          
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45              
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60                  
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80  
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95      
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110         
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125             
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140                 
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160 
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175     
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190         
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205             
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220                 
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240 
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255     
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270         
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285             
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300                 
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320 
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335     
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350         
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365             
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380                 
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400 
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415     
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430         
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445             
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460                 
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480 
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495     
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510         
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525             
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540                 
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560 
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575     
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590         
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605             
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620                 
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640 
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655     
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670         
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685             
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700                 
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720 
Lys Ser Gly Arg Glu Gly Gly Pro Gly Glu Gly Gln Val Arg Arg Pro
                725                 730                 735     
Ala Arg Pro Thr Ile Pro Asn Pro Gly Gly Pro Ala Pro Pro Pro His
            740                 745                 750         
Pro Leu Gln Glu Ser Thr Trp Arg Thr Pro Thr Arg Ser
        755                 760                 765 


<210> 614
<211> 520
<212> PRT
<213> Artificial Sequence

<220> 
<223> SR016E12b	EPHA2

<400> 614
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Gln
        35                  40                  45              
Gly Lys Glu Val Val Leu Leu Asp Phe Ala Ala Ala Gly Gly Glu Leu
    50                  55                  60                  
Gly Trp Leu Thr His Pro Tyr Gly Lys Gly Trp Asp Leu Met Gln Asn
65                  70                  75                  80  
Ile Met Asn Asp Met Pro Ile Tyr Met Tyr Ser Val Cys Asn Val Met
                85                  90                  95      
Ser Gly Asp Gln Asp Asn Trp Leu Arg Thr Asn Trp Val Tyr Arg Gly
            100                 105                 110         
Glu Ala Glu Arg Ile Phe Ile Glu Leu Lys Phe Thr Val Arg Asp Cys
        115                 120                 125             
Asn Ser Phe Pro Gly Gly Ala Ser Ser Cys Lys Glu Thr Phe Asn Leu
    130                 135                 140                 
Tyr Tyr Ala Glu Ser Asp Leu Asp Tyr Gly Thr Asn Phe Gln Lys Arg
145                 150                 155                 160 
Leu Phe Thr Lys Ile Asp Thr Ile Ala Pro Asp Glu Ile Thr Val Ser
                165                 170                 175     
Ser Asp Phe Glu Ala Arg His Val Lys Leu Asn Val Glu Glu Arg Ser
            180                 185                 190         
Val Gly Pro Leu Thr Arg Lys Gly Phe Tyr Leu Ala Phe Gln Asp Ile
        195                 200                 205             
Gly Ala Cys Val Ala Leu Leu Ser Val Arg Val Tyr Tyr Glu Lys Cys
    210                 215                 220                 
Pro Glu Pro Leu Gln Gly Leu Ala His Phe Pro Glu Thr Ile Ala Gly
225                 230                 235                 240 
Ser Asp Ala Pro Ser Leu Ala Thr Val Ala Gly Thr Cys Val Asp His
                245                 250                 255     
Ala Val Val Pro Pro Gly Gly Glu Glu Pro Arg Met His Cys Ala Val
            260                 265                 270         
Asp Gly Glu Trp Leu Val Pro Ile Gly Gln Cys Leu Cys Gln Ala Gly
        275                 280                 285             
Tyr Glu Lys Val Glu Asp Ala Cys Gln Ala Cys Ser Pro Gly Phe Phe
    290                 295                 300                 
Lys Phe Glu Ala Ser Glu Ser Pro Cys Leu Glu Cys Pro Glu Arg Thr
305                 310                 315                 320 
Leu Pro Ser Pro Glu Gly Ala Thr Ser Cys Glu Cys Glu Glu Gly Phe
                325                 330                 335     
Phe Arg Ala Pro Gln Asp Pro Ala Ser Met Pro Cys Thr Arg Pro Pro
            340                 345                 350         
Ser Ala Pro His Tyr Leu Thr Ala Val Gly Met Gly Ala Lys Val Glu
        355                 360                 365             
Leu Arg Trp Thr Pro Pro Gln Asp Ser Gly Gly Arg Glu Asp Ile Val
    370                 375                 380                 
Tyr Ser Val Thr Cys Glu Gln Cys Trp Pro Glu Ser Gly Glu Cys Gly
385                 390                 395                 400 
Pro Cys Glu Ala Ser Val Arg Tyr Ser Glu Pro Pro His Gly Leu Thr
                405                 410                 415     
Arg Thr Ser Val Thr Val Ser Asp Leu Glu Pro His Met Asn Tyr Thr
            420                 425                 430         
Phe Thr Val Glu Ala Arg Asn Gly Val Ser Gly Leu Val Thr Ser Arg
        435                 440                 445             
Ser Phe Arg Thr Ala Ser Val Ser Ile Asn Gln Thr Glu Pro Pro Lys
    450                 455                 460                 
Val Arg Leu Glu Gly Arg Ser Thr Thr Ser Leu Ser Val Ser Trp Ser
465                 470                 475                 480 
Ile Pro Pro Pro Gln Gln Ser Arg Val Trp Lys Tyr Glu Val Thr Tyr
                485                 490                 495     
Arg Lys Lys Val Thr Pro Arg Gly Ala Gly Leu Ala Leu Ala Gly Pro
            500                 505                 510         
Thr Ala Gly Asp Arg Leu Val Thr
        515                 520 


<210> 615
<211> 669
<212> PRT
<213> Artificial Sequence

<220> 
<223> SR014E12b	RON

<400> 615
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Asp
        35                  40                  45              
Trp Gln Cys Pro Arg Thr Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val
    50                  55                  60                  
Lys Tyr Val Val Pro Ser Phe Ser Ala Gly Gly Leu Val Gln Ala Met
65                  70                  75                  80  
Val Thr Tyr Glu Gly Asp Arg Asn Glu Ser Ala Val Phe Val Ala Ile
                85                  90                  95      
Arg Asn Arg Leu His Val Leu Gly Pro Asp Leu Lys Ser Val Gln Ser
            100                 105                 110         
Leu Ala Thr Gly Pro Ala Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala
        115                 120                 125             
Cys Gly Pro Gly Pro His Gly Pro Pro Gly Asp Thr Asp Thr Lys Val
    130                 135                 140                 
Leu Val Leu Asp Pro Ala Leu Pro Ala Leu Val Ser Cys Gly Ser Ser
145                 150                 155                 160 
Leu Gln Gly Arg Cys Phe Leu His Asp Leu Glu Pro Gln Gly Thr Ala
                165                 170                 175     
Val His Leu Ala Ala Pro Ala Cys Leu Phe Ser Ala His His Asn Arg
            180                 185                 190         
Pro Asp Asp Cys Pro Asp Cys Val Ala Ser Pro Leu Gly Thr Arg Val
        195                 200                 205             
Thr Val Val Glu Gln Gly Gln Ala Ser Tyr Phe Tyr Ala Ala Ser Ser
    210                 215                 220                 
Leu Asp Ala Ala Val Ala Ala Ser Phe Ser Pro Arg Ser Val Ser Ile
225                 230                 235                 240 
Arg Arg Leu Lys Ala Asp Ala Ser Gly Phe Ala Pro Gly Phe Val Thr
                245                 250                 255     
Leu Ser Val Leu Pro Lys His Leu Val Ser Tyr Ser Ile Glu Tyr Val
            260                 265                 270         
His Ser Phe His Thr Gly Ala Phe Val Tyr Phe Leu Thr Val Gln Pro
        275                 280                 285             
Ala Ser Val Thr Asp Asp Pro Ser Ala Leu His Thr Arg Leu Ala Arg
    290                 295                 300                 
Leu Ser Ala Thr Glu Pro Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu
305                 310                 315                 320 
Asp Cys Arg Phe Ala Pro Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly
                325                 330                 335     
Gly Gln Pro Tyr Pro Val Leu Arg Val Ala His Ser Ala Pro Val Gly
            340                 345                 350         
Ala Gln Leu Ala Thr Glu Leu Ser Ile Ala Glu Gly Gln Glu Val Leu
        355                 360                 365             
Phe Gly Val Phe Val Thr Gly Lys Asp Gly Gly Pro Gly Val Gly Pro
    370                 375                 380                 
Asn Ser Val Val Cys Ala Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile
385                 390                 395                 400 
Asp Glu Gly Val Glu Arg Cys Cys Glu Ser Pro Val His Pro Gly Leu
                405                 410                 415     
Arg Arg Gly Leu Asp Phe Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro
            420                 425                 430         
Pro Gly Leu Glu Ala Leu Ser Pro Asn Thr Ser Cys Arg His Phe Pro
        435                 440                 445             
Leu Leu Val Ser Ser Ser Phe Ser Arg Val Asp Leu Phe Asn Gly Leu
    450                 455                 460                 
Leu Gly Pro Val Gln Val Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn
465                 470                 475                 480 
Val Thr Val Ala His Met Gly Thr Met Asp Gly Arg Ile Leu Gln Val
                485                 490                 495     
Glu Leu Val Arg Ser Leu Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser
            500                 505                 510         
Leu Gly Asp Ser Gly Gln Pro Val Gln Arg Asp Val Ser Arg Leu Gly
        515                 520                 525             
Asp His Leu Leu Phe Ala Ser Gly Asp Gln Val Phe Gln Val Pro Ile
    530                 535                 540                 
Arg Gly Pro Gly Cys Arg His Phe Leu Thr Cys Gly Arg Cys Leu Arg
545                 550                 555                 560 
Ala Trp His Phe Met Gly Cys Gly Trp Cys Gly Asn Val Cys Gly Gln
                565                 570                 575     
Gln Lys Glu Cys Pro Gly Ser Trp Gln Gln Asp His Cys Pro Pro Lys
            580                 585                 590         
Leu Thr Glu Phe His Pro His Ser Gly Pro Leu Arg Gly Ser Thr Arg
        595                 600                 605             
Leu Thr Leu Cys Gly Ser Asn Phe Tyr Leu His Pro Ser Gly Leu Val
    610                 615                 620                 
Pro Glu Gly Thr His Gln Val Thr Val Gly Gln Ser Pro Cys Arg Pro
625                 630                 635                 640 
Leu Pro Lys Asp Ser Ser Lys Leu Arg Tyr Asn Leu Val Pro Pro Leu
                645                 650                 655     
Pro Phe Pro Glu Gly Gly Asn Gln Ala Ala Pro Ser Pro
            660                 665                 


<210> 616
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> SR002A10b	FGFR4

<400> 616
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Glu
        35                  40                  45              
Glu Val Glu Leu Glu Pro Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu
    50                  55                  60                  
Gln Glu Leu Thr Val Ala Leu Gly Gln Pro Val Arg Leu Cys Cys Gly
65                  70                  75                  80  
Arg Ala Glu Arg Gly Gly His Trp Tyr Lys Glu Gly Ser Arg Leu Ala
                85                  90                  95      
Pro Ala Gly Arg Val Arg Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser
            100                 105                 110         
Phe Leu Pro Glu Asp Ala Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser
        115                 120                 125             
Met Ile Val Leu Gln Asn Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr
    130                 135                 140                 
Ser Ser Asn Asp Asp Glu Asp Pro Lys Ser His Arg Asp Pro Ser Asn
145                 150                 155                 160 
Arg His Ser Tyr Pro Gln Gln Ala Pro Tyr Trp Thr His Pro Gln Arg
                165                 170                 175     
Met Glu Lys Lys Leu His Ala Val Pro Ala Gly Asn Thr Val Lys Phe
            180                 185                 190         
Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys
        195                 200                 205             
Asp Gly Gln Ala Phe His Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu
    210                 215                 220                 
Arg His Gln His Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp
225                 230                 235                 240 
Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn Ala Val Gly Ser Ile Cys
                245                 250                 255     
Tyr Asn Tyr Leu Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile
            260                 265                 270         
Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr Ala Val Val Gly Ser Asp
        275                 280                 285             
Val Glu Leu Leu Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln
    290                 295                 300                 
Trp Leu Lys His Ile Val Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly
305                 310                 315                 320 
Phe Pro Tyr Val Gln Val Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu
                325                 330                 335     
Val Glu Val Leu Tyr Leu Arg Asn Val Ser Ala Glu Asp Ala Gly Glu
            340                 345                 350         
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala
        355                 360                 365             
Trp Leu Thr Val Leu Pro Gly Glu His Leu Lys Gly Gln Glu Met Leu
    370                 375                 380                 
Arg Asp Ala Pro Leu Gly Gln Gln Trp Gly Leu Trp Pro Val Gly Trp
385                 390                 395                 400 
Ser Val Ser Val Gly Leu Trp Gly Leu Ala Trp Gly Ala Val Cys Gly
                405                 410                 415     
Phe Val Gly Leu Ser Cys Met Thr Ala Pro Leu Cys Leu Ser Thr Arg
            420                 425                 430         
Gly Arg Pro Cys Asp Arg Leu Leu Arg Cys Gly Cys Leu Gly Leu Gly
        435                 440                 445             
Ile Thr Thr Ala Ser Ser Val Cys Val Pro Thr Tyr Val Gly Ser Trp
    450                 455                 460                 
Glu Gly Leu Ser
465             


<210> 617
<211> 395
<212> PRT
<213> Artificial Sequence

<220> 
<223> SR007G02b	TIE-2

<400> 617
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30          
Gly Ala Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu Val
        35                  40                  45              
Glu Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu Pro Leu Val Ser
    50                  55                  60                  
Asp Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly Trp Arg Pro His
65                  70                  75                  80  
Glu Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu Met Asn Gln His
                85                  90                  95      
Gln Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg Glu Trp Ala Lys
            100                 105                 110         
Lys Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile Asn Gly Ala Tyr
        115                 120                 125             
Phe Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg Ile Arg Thr Met
    130                 135                 140                 
Lys Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr Leu Thr Met Thr
145                 150                 155                 160 
Val Asp Lys Gly Asp His Val Asn Ile Ser Phe Lys Lys Val Leu Ile
                165                 170                 175     
Lys Glu Glu Asp Ala Ala Ile Tyr Lys Asn Gly Ser Phe Ile His Ser
            180                 185                 190         
Val Pro Arg His Glu Val Pro Asp Ile Leu Glu Val His Leu Pro His
        195                 200                 205             
Ala Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg Tyr Val Gly Gly
    210                 215                 220                 
Asn Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val Arg Arg Cys Glu
225                 230                 235                 240 
Ala Gln Lys Trp Gly Pro Glu Cys Asn His Leu Cys Thr Ala Cys Met
                245                 250                 255     
Asn Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys Ile Cys Pro Pro
            260                 265                 270         
Gly Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu Leu His Thr Phe
        275                 280                 285             
Gly Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Glu Gly Cys Lys Ser
    290                 295                 300                 
Tyr Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser Cys Ala Ala Gly
305                 310                 315                 320 
Trp Lys Gly Leu Gln Cys Asn Glu Ala Cys His Pro Gly Phe Tyr Gly
                325                 330                 335     
Pro Asp Cys Lys Leu Arg Cys Ser Cys Asn Asn Gly Glu Met Cys Asp
            340                 345                 350         
Arg Phe Gln Gly Cys Leu Cys Ser Pro Gly Trp Gln Gly Leu Gln Cys
        355                 360                 365             
Glu Arg Glu Gly Lys Ala Arg His Thr Glu Asp Asp Pro Lys Asp Ser
    370                 375                 380                 
Gly Phe Ala Arg Ser Tyr Arg Ser Lys Gln Trp
385                 390                 395 


<210> 618
<211> 751
<212> PRT
<213> Artificial Sequence

<220> 
<223> SR016G03b	TIE-1

<400> 618
Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala
 1               5                  10                  15      
Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg
            20                  25                  30          
Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala
        35                  40                  45              
Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu
    50                  55                  60                  
Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu
65                  70                  75                  80  
Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro
                85                  90                  95      
Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg
            100                 105                 110         
Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu
        115                 120                 125             
Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Ala Val Leu
    130                 135                 140                 
Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser
145                 150                 155                 160 
Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly
                165                 170                 175     
Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile
            180                 185                 190         
Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly Ser Ala Phe Phe
        195                 200                 205             
Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp Gly Pro Gly Cys
    210                 215                 220                 
Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val Cys His Asp His
225                 230                 235                 240 
Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly Thr Arg Cys Glu
                245                 250                 255     
Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys Gln Glu Gln Cys
            260                 265                 270         
Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys Leu Pro Asp Pro
        275                 280                 285             
Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser Gln Cys Gln Glu
    290                 295                 300                 
Ala Cys Ala Pro Gly His Phe Gly Ala Asp Cys Arg Leu Gln Cys Gln
305                 310                 315                 320 
Cys Gln Asn Gly Gly Thr Cys Asp Arg Phe Ser Gly Cys Val Cys Pro
                325                 330                 335     
Ser Gly Trp His Gly Val His Cys Glu Lys Ser Asp Arg Ile Pro Gln
            340                 345                 350         
Ile Leu Asn Met Ala Ser Glu Leu Glu Phe Asn Leu Glu Thr Met Pro
        355                 360                 365             
Arg Ile Asn Cys Ala Ala Ala Gly Asn Pro Phe Pro Val Arg Gly Ser
    370                 375                 380                 
Ile Glu Leu Arg Lys Pro Asp Gly Thr Val Leu Leu Ser Thr Lys Ala
385                 390                 395                 400 
Ile Val Glu Pro Glu Lys Thr Thr Ala Glu Phe Glu Val Pro Arg Leu
                405                 410                 415     
Val Leu Ala Asp Ser Gly Phe Trp Glu Cys Arg Val Ser Thr Ser Gly
            420                 425                 430         
Gly Gln Asp Ser Arg Arg Phe Lys Val Asn Val Lys Val Pro Pro Val
        435                 440                 445             
Pro Leu Ala Ala Pro Arg Leu Leu Thr Lys Gln Ser Arg Gln Leu Val
    450                 455                 460                 
Val Ser Pro Leu Val Ser Phe Ser Gly Asp Gly Pro Ile Ser Thr Val
465                 470                 475                 480 
Arg Leu His Tyr Arg Pro Gln Asp Ser Thr Met Asp Trp Ser Thr Ile
                485                 490                 495     
Val Val Asp Pro Ser Glu Asn Val Thr Leu Met Asn Leu Arg Pro Lys
            500                 505                 510         
Thr Gly Tyr Ser Val Arg Val Gln Leu Ser Arg Pro Gly Glu Gly Gly
        515                 520                 525             
Glu Gly Ala Trp Gly Pro Pro Thr Leu Met Thr Thr Asp Cys Pro Glu
    530                 535                 540                 
Pro Leu Leu Gln Pro Trp Leu Glu Gly Trp His Val Glu Gly Thr Asp
545                 550                 555                 560 
Arg Leu Arg Val Ser Trp Ser Leu Pro Leu Val Pro Gly Pro Leu Val
                565                 570                 575     
Gly Asp Gly Phe Leu Leu Arg Leu Trp Asp Gly Thr Arg Gly Gln Glu
            580                 585                 590         
Arg Arg Glu Asn Val Ser Ser Pro Gln Ala Arg Thr Ala Leu Leu Thr
        595                 600                 605             
Gly Leu Thr Pro Gly Thr His Tyr Gln Leu Asp Val Gln Leu Tyr His
    610                 615                 620                 
Cys Thr Leu Leu Gly Pro Ala Ser Pro Pro Ala His Val Leu Leu Pro
625                 630                 635                 640 
Pro Ser Gly Pro Pro Ala Pro Arg His Leu His Ala Gln Ala Leu Ser
                645                 650                 655     
Asp Ser Glu Ile Gln Leu Thr Trp Lys His Pro Glu Ala Leu Pro Gly
            660                 665                 670         
Pro Ile Ser Lys Tyr Val Val Glu Val Gln Val Ala Gly Gly Ala Gly
        675                 680                 685             
Asp Pro Leu Trp Ile Asp Val Asp Arg Pro Glu Glu Thr Ser Thr Ile
    690                 695                 700                 
Ile Arg Gly Leu Asn Ala Ser Thr Arg Tyr Leu Phe Arg Met Arg Ala
705                 710                 715                 720 
Ser Ile Gln Gly Leu Gly Asp Trp Ser Asn Thr Val Glu Glu Ser Thr
                725                 730                 735     
Leu Gly Asn Gly Glu Arg Ala Gly Pro Thr Gly Pro Pro Gly Leu
            740                 745                 750     




