                         SEQUENCE LISTING

<110>  The Penn State Research Foundation
 
<120>  METHODS AND COMPOSITIONS RELATING TO PBK1

<130>  PST-25952/36

<150>  60/939,462
<151>  2007-05-22

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  3506
<212>  DNA
<213>  Homo sapiens

<400>  1
gctgttcggc tcagctgcac ggctcggctc ggctcggctc ggctcggctg cgcggccgct       60

gacgggcgtg cgctgggggc gcggggcgcg gggcgcgggc ctcggcggcg gcggcggcgg      120

cggcggcgga agccaggtgc ccccgcccgc cctgtcctct cgacgaggcg gaggcgtcgc      180

cgcgggccag gcctcggact gccgcgtcgg agtggacgcg gggggcggcg gcgcgggcgg      240

acgcgggcgg cgcgaagcag cggggcccgc gggggcgccc cggccgggtc ggcgcggacg      300

gcactcggcg gacgcgggcg gacgctgggc ggcccctccc tgcccgcgcg cccgggcgcc      360

cctggccggc gccgggcccc agagcgatga catcgacggg gaaggacggc ggcgcgcagc      420

acgcgcagta tgttgggccc taccggctgg agaagacgct gggcaagggg cagacaggtc      480

tggtgaagct gggggttcac tgcgtcacct gccagaaggt ggccatcaag atcgtcaacc      540

gtgagaagct cagcgagtcg gtgctgatga aggtggagcg ggagatcgcg atcctgaagc      600

tcattgagca cccccacgtc ctaaagctgc acgacgttta tgaaaacaaa aaatatttgt      660

acctggtgct agaacacgtg tcaggtggtg agctcttcga ctacctggtg aagaagggga      720

ggctgacgcc taaggaggct cggaagttct tccggcagat catctctgcg ctggacttct      780

gccacagcca ctccatatgc cacagggatc tgaaacctga aaacctcctg ctggacgaga      840

agaacaacat ccgcatcgca gactttggca tggcgtccct gcaggttggc gacagcctgt      900

tggagaccag ctgtgggtcc ccccactacg cctgccccga ggtgatccgg ggggagaagt      960

atgacggccg gaaggcggac gtgtggagct gcggcgtcat cctgttcgcc ttgctggtgg     1020

gggctctgcc cttcgacgat gacaacttgc gacagctgct ggagaaggtg aagcggggcg     1080

tgttccacat gccgcacttt atcccgcccg actgccagag tctgctacgg ggcatgatcg     1140

aggtggacgc cgcacgccgc ctcacgctag agcacattca gaaacacata tggtatatag     1200

ggggcaagaa tgagcccgaa ccagagcagc ccattcctcg caaggtgcag atccgctcgc     1260

tgcccagcct ggaggacatc gaccccgacg tgctggacag catgcactca ctgggctgct     1320

tccgagaccg caacaagctg ctgcaggacc tgctgtccga ggaggagaac caggagaaga     1380

tgatttactt cctcctcctg gaccggaaag aaaggtaccc gagccaggag gatgaggacc     1440

tgcccccccg gaacgagata gaccctcccc ggaagcgtgt ggactccccg atgctgaacc     1500

ggcacggcaa gcggcggcca gaacgcaaat ccatggaggt gctcagcgtg acggacggcg     1560

gctccccggt gcctgcgcgg cgggccattg agatggccca gcacggccag aggtctcggt     1620

ccatcagcgg tgcctcctca ggcctttcca ccagcccact cagcagcccc cgggtgaccc     1680

ctcacccctc accaaggggc agtcccctcc ccacccccaa ggggacacct gtccacacgc     1740

caaaggagag cccggctggc acgcccaacc ccacgccccc gtccagcccc agcgtcggag     1800

gggtgccctg gagggcgcgg ctcaactcca tcaagaacag ctttctgggc tcaccccgct     1860

tccaccgccg gaaactgcaa gttccgacgc cggaggagat gtccaacctg acaccagagt     1920

cgtccccaga gctggcgaag aagtcctggt ttgggaactt catcagcctg gagaaggagg     1980

agcagatctt cgtggtcatc aaagacaaac ctctgagctc catcaaggct gacatcgtgc     2040

acgccttcct gtcgattccc agtctcagcc acagcgtcat ctcccaaacg agcttccggg     2100

ccgagtacaa ggccacgggg gggccagccg tgttccagaa gccggtcaag ttccaggttg     2160

atatcaccta cacggagggt ggggaggcgc agaaggagaa cggcatctac tccgtcacct     2220

tcaccctgct ctcaggcccc agccgtcgct tcaagagggt ggtggagacc atccaggccc     2280

agctgctgag cacacacgac ccgcctgcgg cccagcactt gtcagacacc actaactgta     2340

tggaaatgat gacggggcgg ctttccaaat gtggaattat cccgaaaagt taacatgtca     2400

cctccacgag gccatcctct gtgaccgaag gcagctgctg cggacccgcc ctccctccgc     2460

tcctgctgtt gctgccgggc agtgaggccc agcccagcgc cccgtccacc ccgcggcagc     2520

tcctcgcctc agctccgcac ggcccgtggg aggaaggcca ggctcggggg agcctcctcc     2580

agcccggccg acccggactc ccggtcacct gacccctcag caagaacagc ctgcctggtg     2640

gccttctggg gccaggaccc ctggtgggca acgtagccac aggaacaggc cccgtccacc     2700

gcctccacgc cgcacctgga ggcctcctcg caggcccgtg ccccgcctcc ctggctgcgc     2760

cgcctccgtg tagtcttggc ctcctcaggc tgcctcccgt cctctcgtct cacccgcgcc     2820

tcccttgcct catctggggc ggctgtgggc tctggcgctc ctctctggct gaggtggaaa     2880

cagagacacc ctgcggcacc agagccttcc cagcaggcca ggccgctggg ctgggatcag     2940

tgttatttat ttgccgtttt aatttatgga ttctccgcac ctctgttcag ggaagggcgg     3000

cggccacatc ccctgccgtc tgcgtgtctc aggcagtggg ggggctgggg ccagggcgcc     3060

ctctgaggac agagctggtg gggcgcgggg gggctggcga gctactgtaa actttaaaga     3120

attcctgcaa gatattttta taaacttttt tttcttggtg gtttttggaa aagggtgtgg     3180

gggtgggggc gccgctgggg cagggccagg ttttgtgttt tagtcccttg ctcctgcttc     3240

tttctacaca cacatctaaa gacggtgcgg ctcgctctgt catgggttcc gtctctctgt     3300

ggagaagcag ctccacctct gggggggctc ggggcagagg ggcggtgtct cgtagcgggc     3360

ggcagcgcca gcgcccctct gtcaggctgg ggcaatcttg gttttgtgtc caaaggtgaa     3420

ggggtaggag gagggccctc agctggccct ccccacacac aggacggcag gggcactgtg     3480

aggcttttct tattaaaatg aaaaaa                                          3506


<210>  2
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Ser Thr Gly Lys Asp Gly Gly Ala Gln His Ala Gln Tyr Val 
1               5                   10                  15      


Gly Pro Tyr Arg Leu Glu Lys Thr Leu Gly Lys Gly Gln Thr Gly Leu 
            20                  25                  30          


Val Lys Leu Gly Val His Cys Val Thr Cys Gln Lys Val Ala Ile Lys 
        35                  40                  45              


Ile Val Asn Arg Glu Lys Leu Ser Glu Ser Val Leu Met Lys Val Glu 
    50                  55                  60                  


Arg Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro His Val Leu Lys 
65                  70                  75                  80  


Leu His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr Leu Val Leu Glu 
                85                  90                  95      


His Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys Gly Arg 
            100                 105                 110         


Leu Thr Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Ile Ser Ala 
        115                 120                 125             


Leu Asp Phe Cys His Ser His Ser Ile Cys His Arg Asp Leu Lys Pro 
    130                 135                 140                 


Glu Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala Asp Phe 
145                 150                 155                 160 


Gly Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Thr Ser Cys 
                165                 170                 175     


Gly Ser Pro His Tyr Ala Cys Pro Glu Val Ile Arg Gly Glu Lys Tyr 
            180                 185                 190         


Asp Gly Arg Lys Ala Asp Val Trp Ser Cys Gly Val Ile Leu Phe Ala 
        195                 200                 205             


Leu Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg Gln Leu 
    210                 215                 220                 


Leu Glu Lys Val Lys Arg Gly Val Phe His Met Pro His Phe Ile Pro 
225                 230                 235                 240 


Pro Asp Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Asp Ala Ala 
                245                 250                 255     


Arg Arg Leu Thr Leu Glu His Ile Gln Lys His Ile Trp Tyr Ile Gly 
            260                 265                 270         


Gly Lys Asn Glu Pro Glu Pro Glu Gln Pro Ile Pro Arg Lys Val Gln 
        275                 280                 285             


Ile Arg Ser Leu Pro Ser Leu Glu Asp Ile Asp Pro Asp Val Leu Asp 
    290                 295                 300                 


Ser Met His Ser Leu Gly Cys Phe Arg Asp Arg Asn Lys Leu Leu Gln 
305                 310                 315                 320 


Asp Leu Leu Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr Phe Leu 
                325                 330                 335     


Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Gln Glu Asp Glu Asp Leu 
            340                 345                 350         


Pro Pro Arg Asn Glu Ile Asp Pro Pro Arg Lys Arg Val Asp Ser Pro 
        355                 360                 365             


Met Leu Asn Arg His Gly Lys Arg Arg Pro Glu Arg Lys Ser Met Glu 
    370                 375                 380                 


Val Leu Ser Val Thr Asp Gly Gly Ser Pro Val Pro Ala Arg Arg Ala 
385                 390                 395                 400 


Ile Glu Met Ala Gln His Gly Gln Arg Ser Arg Ser Ile Ser Gly Ala 
                405                 410                 415     


Ser Ser Gly Leu Ser Thr Ser Pro Leu Ser Ser Pro Arg Val Thr Pro 
            420                 425                 430         


His Pro Ser Pro Arg Gly Ser Pro Leu Pro Thr Pro Lys Gly Thr Pro 
        435                 440                 445             


Val His Thr Pro Lys Glu Ser Pro Ala Gly Thr Pro Asn Pro Thr Pro 
    450                 455                 460                 


Pro Ser Ser Pro Ser Val Gly Gly Val Pro Trp Arg Ala Arg Leu Asn 
465                 470                 475                 480 


Ser Ile Lys Asn Ser Phe Leu Gly Ser Pro Arg Phe His Arg Arg Lys 
                485                 490                 495     


Leu Gln Val Pro Thr Pro Glu Glu Met Ser Asn Leu Thr Pro Glu Ser 
            500                 505                 510         


Ser Pro Glu Leu Ala Lys Lys Ser Trp Phe Gly Asn Phe Ile Ser Leu 
        515                 520                 525             


Glu Lys Glu Glu Gln Ile Phe Val Val Ile Lys Asp Lys Pro Leu Ser 
    530                 535                 540                 


Ser Ile Lys Ala Asp Ile Val His Ala Phe Leu Ser Ile Pro Ser Leu 
545                 550                 555                 560 


Ser His Ser Val Ile Ser Gln Thr Ser Phe Arg Ala Glu Tyr Lys Ala 
                565                 570                 575     


Thr Gly Gly Pro Ala Val Phe Gln Lys Pro Val Lys Phe Gln Val Asp 
            580                 585                 590         


Ile Thr Tyr Thr Glu Gly Gly Glu Ala Gln Lys Glu Asn Gly Ile Tyr 
        595                 600                 605             


Ser Val Thr Phe Thr Leu Leu Ser Gly Pro Ser Arg Arg Phe Lys Arg 
    610                 615                 620                 


Val Val Glu Thr Ile Gln Ala Gln Leu Leu Ser Thr His Asp Pro Pro 
625                 630                 635                 640 


Ala Ala Gln His Leu Ser Asp Thr Thr Asn Cys Met Glu Met Met Thr 
                645                 650                 655     


Gly Arg Leu Ser Lys Cys Gly Ile Ile Pro Lys Ser 
            660                 665             


<210>  3
<211>  3109
<212>  DNA
<213>  Homo sapiens

<400>  3
gggggccggc cagaaacggg ctggggaggg ggggccccgc agcccccctg ggccatgctg       60

actcccgggg cctgaccccc ccgggccagc cccccctccc ccagctccgc ggcccgccga      120

ctgggggggg ccagcccagc cccctgggga cccccggaga ggtggggggc agccgggggg      180

gccgggacgg agcggtcgcc ggcccccacc ggagagacgg ggcgacggcc gcaggggggg      240

cggccggggg accggtcggg ccgggaccaa gggcaccatg tcgtccgggg ccaaggaggg      300

aggtgggggc tctcccgcct accacctccc ccacccccac ccccacccac cccagcacgc      360

ccaatatgtg ggcccctatc ggctggagaa gacgctgggc aaaggacaga cagggctggt      420

taaactcggg gtccactgca tcacgggtca gaaggtcgcc atcaagatcg tgaaccggga      480

gaagctgtcg gagtcggtgc tgatgaaggt ggagcgggag atcgccatcc tgaagctcat      540

cgaacaccca catgtcctca agctccacga cgtctacgag aacaagaaat atttgtacct      600

ggttctggag cacgtctcgg ggggtgagct attcgactac ctggtaaaga aggggagact      660

gacgcccaag gaggcccgaa agttcttccg ccagattgtg tctgcgctgg acttctgcca      720

cagctactcc atctgccaca gagacctaaa gcccgagaac ctgcttttgg atgagaaaaa      780

caacatccgc attgcagact tcggcatggc gtccctgcag gtgggggaca gcctcctgga      840

gaccagctgc gggtcccccc attatgcgtg tccagaggtg attaaggggg aaaaatatga      900

tggccgccgg gcagacatgt ggagctgtgg agtcatcctc ttcgccctgc tcgtgggggc      960

tctgcccttt gatgacgaca acctccgcca gctgctggag aaggtgaaac ggggcgtctt     1020

ccacatgccc cacttcattc ctccagattg ccagagcctc ctgaggggaa tgatcgaagt     1080

ggagcccgaa aaaaggctca gtctggagca aattcagaaa catccttggt acctaggcgg     1140

gaaacacgag ccagacccgt gcctggagcc agcccctggc cgccgggtag ccatgcggag     1200

cctgccatcc aacggagagc tggaccccga cgtcctagag agcatggcat cactgggctg     1260

cttcagggac cgcgagaggc tgcatcgcga gctgcgcagt gaggaggaga accaagaaaa     1320

gatgatatat tatctgcttt tggatcggaa ggagcggtat cccagctgtg aggaccagga     1380

cctgcctccc cggaatgatg ttgacccccc ccggaagcgt gtggattctc ccatgctgag     1440

ccgtcacggg aagcggcgac cagagcggaa gtccatggaa gtcctgagca tcaccgatgc     1500

cgggggtggt ggctcccctg tacccacccg acgggccttg gagatggccc agcacagcca     1560

gagatcccgt agcgtcagtg gagcctccac gggtctgtcc tccagccctc taagcagccc     1620

aaggagtccg gtcttttcct tttcaccgga gccgggggct ggagatgagg ctcgaggcgg     1680

gggctccccg acttccaaaa cgcagacgct gccttctcgg ggccccaggg gtgggggcgc     1740

cggggagcag cccccgcccc ccagtgcccg ctccacaccc ctgcccggcc ccccaggctc     1800

cccgcgctcc tctggcggga cccccttgca ctcgcctctg cacacgcccc gggccagtcc     1860

caccgggacc ccggggacaa caccaccccc cagccccggc ggtggcgtcg ggggagccgc     1920

ctggaggagt cgtctcaact ccatccgcaa cagcttcctg ggctcccctc gctttcaccg     1980

gcgcaagatg caggtcccta ccgctgagga gatgtccagc ttgacgccag agtcctcccc     2040

ggagctggca aaacgctcct ggttcgggaa cttcatctcc ttggacaaag aagaacaaat     2100

attcctcgtg ctaaaggaca aacctctcag cagcatcaaa gcagacatcg tccatgcctt     2160

tctgtcgatc cccagcctga gtcacagtgt gctgtcacag accagcttca gggccgagta     2220

caaggccagt ggcggcccct ccgtcttcca aaagcccgtc cgcttccagg tggacatcag     2280

ctcctctgag ggtccagagc cctccccgcg acgggacggc agcggaggtg gtggcatcta     2340

ctccgtcacc ttcactctca tctcgggtcc cagccgtcgg ttcaagcgag tggtggagac     2400

catccaggca cagctcctga gcactcatga ccagccctcc gtgcaggccc tggcagacga     2460

gaagaacggg gcccagaccc ggcctgctgg tgccccaccc cgaagcctgc agcccccacc     2520

cggccgccca gacccagagc tgagcagctc tccccgccga ggccccccca aggacaagaa     2580

gctcctggcc accaacggga cccctctgcc ctgaccccac ggggccgggg agggagggga     2640

cccccctcca ccccccttcc gtgcccccca actgtgaatc tgtaaataag gcccaaggaa     2700

catgtcggga ggggggtgga cacaaaaacc ggccttgccc tgcagggatg gggctccaca     2760

ggccgtgccc aactgggggt ggttctaggg gaacaggggg cgggggagct gtttctattt     2820

tatttattga ttaatttatt attttattta ttgatcaatc tctctgcggg gtggggtggg     2880

ggagggacgg gagctggttg gggtggctta gcagatccgg acagggccct ctgtccctgt     2940

gtcgtcccca accccctctt cccgggcccc tcctcccctg gtcctccccc cacgaccttc     3000

tgtacggatt tgctctccgg aaggaattct ggtttcgcgt gatcctgcct gcgtccgtgt     3060

ctctgattcc gccggcggca aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                 3109


<210>  4
<211>  778
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Ser Gly Ala Lys Glu Gly Gly Gly Gly Ser Pro Ala Tyr His 
1               5                   10                  15      


Leu Pro His Pro His Pro His Pro Pro Gln His Ala Gln Tyr Val Gly 
            20                  25                  30          


Pro Tyr Arg Leu Glu Lys Thr Leu Gly Lys Gly Gln Thr Gly Leu Val 
        35                  40                  45              


Lys Leu Gly Val His Cys Ile Thr Gly Gln Lys Val Ala Ile Lys Ile 
    50                  55                  60                  


Val Asn Arg Glu Lys Leu Ser Glu Ser Val Leu Met Lys Val Glu Arg 
65                  70                  75                  80  


Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro His Val Leu Lys Leu 
                85                  90                  95      


His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr Leu Val Leu Glu His 
            100                 105                 110         


Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys Gly Arg Leu 
        115                 120                 125             


Thr Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Val Ser Ala Leu 
    130                 135                 140                 


Asp Phe Cys His Ser Tyr Ser Ile Cys His Arg Asp Leu Lys Pro Glu 
145                 150                 155                 160 


Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala Asp Phe Gly 
                165                 170                 175     


Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Thr Ser Cys Gly 
            180                 185                 190         


Ser Pro His Tyr Ala Cys Pro Glu Val Ile Lys Gly Glu Lys Tyr Asp 
        195                 200                 205             


Gly Arg Arg Ala Asp Met Trp Ser Cys Gly Val Ile Leu Phe Ala Leu 
    210                 215                 220                 


Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg Gln Leu Leu 
225                 230                 235                 240 


Glu Lys Val Lys Arg Gly Val Phe His Met Pro His Phe Ile Pro Pro 
                245                 250                 255     


Asp Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Glu Pro Glu Lys 
            260                 265                 270         


Arg Leu Ser Leu Glu Gln Ile Gln Lys His Pro Trp Tyr Leu Gly Gly 
        275                 280                 285             


Lys His Glu Pro Asp Pro Cys Leu Glu Pro Ala Pro Gly Arg Arg Val 
    290                 295                 300                 


Ala Met Arg Ser Leu Pro Ser Asn Gly Glu Leu Asp Pro Asp Val Leu 
305                 310                 315                 320 


Glu Ser Met Ala Ser Leu Gly Cys Phe Arg Asp Arg Glu Arg Leu His 
                325                 330                 335     


Arg Glu Leu Arg Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr Tyr 
            340                 345                 350         


Leu Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Cys Glu Asp Gln Asp 
        355                 360                 365             


Leu Pro Pro Arg Asn Asp Val Asp Pro Pro Arg Lys Arg Val Asp Ser 
    370                 375                 380                 


Pro Met Leu Ser Arg His Gly Lys Arg Arg Pro Glu Arg Lys Ser Met 
385                 390                 395                 400 


Glu Val Leu Ser Ile Thr Asp Ala Gly Gly Gly Gly Ser Pro Val Pro 
                405                 410                 415     


Thr Arg Arg Ala Leu Glu Met Ala Gln His Ser Gln Arg Ser Arg Ser 
            420                 425                 430         


Val Ser Gly Ala Ser Thr Gly Leu Ser Ser Ser Pro Leu Ser Ser Pro 
        435                 440                 445             


Arg Ser Pro Val Phe Ser Phe Ser Pro Glu Pro Gly Ala Gly Asp Glu 
    450                 455                 460                 


Ala Arg Gly Gly Gly Ser Pro Thr Ser Lys Thr Gln Thr Leu Pro Ser 
465                 470                 475                 480 


Arg Gly Pro Arg Gly Gly Gly Ala Gly Glu Gln Pro Pro Pro Pro Ser 
                485                 490                 495     


Ala Arg Ser Thr Pro Leu Pro Gly Pro Pro Gly Ser Pro Arg Ser Ser 
            500                 505                 510         


Gly Gly Thr Pro Leu His Ser Pro Leu His Thr Pro Arg Ala Ser Pro 
        515                 520                 525             


Thr Gly Thr Pro Gly Thr Thr Pro Pro Pro Ser Pro Gly Gly Gly Val 
    530                 535                 540                 


Gly Gly Ala Ala Trp Arg Ser Arg Leu Asn Ser Ile Arg Asn Ser Phe 
545                 550                 555                 560 


Leu Gly Ser Pro Arg Phe His Arg Arg Lys Met Gln Val Pro Thr Ala 
                565                 570                 575     


Glu Glu Met Ser Ser Leu Thr Pro Glu Ser Ser Pro Glu Leu Ala Lys 
            580                 585                 590         


Arg Ser Trp Phe Gly Asn Phe Ile Ser Leu Asp Lys Glu Glu Gln Ile 
        595                 600                 605             


Phe Leu Val Leu Lys Asp Lys Pro Leu Ser Ser Ile Lys Ala Asp Ile 
    610                 615                 620                 


Val His Ala Phe Leu Ser Ile Pro Ser Leu Ser His Ser Val Leu Ser 
625                 630                 635                 640 


Gln Thr Ser Phe Arg Ala Glu Tyr Lys Ala Ser Gly Gly Pro Ser Val 
                645                 650                 655     


Phe Gln Lys Pro Val Arg Phe Gln Val Asp Ile Ser Ser Ser Glu Gly 
            660                 665                 670         


Pro Glu Pro Ser Pro Arg Arg Asp Gly Ser Gly Gly Gly Gly Ile Tyr 
        675                 680                 685             


Ser Val Thr Phe Thr Leu Ile Ser Gly Pro Ser Arg Arg Phe Lys Arg 
    690                 695                 700                 


Val Val Glu Thr Ile Gln Ala Gln Leu Leu Ser Thr His Asp Gln Pro 
705                 710                 715                 720 


Ser Val Gln Ala Leu Ala Asp Glu Lys Asn Gly Ala Gln Thr Arg Pro 
                725                 730                 735     


Ala Gly Ala Pro Pro Arg Ser Leu Gln Pro Pro Pro Gly Arg Pro Asp 
            740                 745                 750         


Pro Glu Leu Ser Ser Ser Pro Arg Arg Gly Pro Pro Lys Asp Lys Lys 
        755                 760                 765             


Leu Leu Ala Thr Asn Gly Thr Pro Leu Pro 
    770                 775             


<210>  5
<211>  3576
<212>  DNA
<213>  Homo sapiens

<400>  5
agtctcaggc tggctagttc ctccttcctg gtcactgagc cagccttgct gaggggagag       60

cgggttctgg acgtgctctg agcttccttc ctcacagcct tgctcctggg ccagatcagc      120

aggaaagcag ccagtgcccc gccatggcct gcccgggtgg ggtcctgaag ctggggccgg      180

agcagggggc acagttctgc cccatctggc cctagtttgg ggagggagcc tggtagggca      240

ccagcctcac cccatgagcc ctgagggcca ccccagccga tgggcacgtc cccgccggcc      300

ctgcatctgt ccttcctccc tctgctcccc aagagagccc aggtctggcc cagcggtggg      360

caggggaggg gccgcacatc acagagtgcc agctggccac actcccggcc cacagctgct      420

ccagccgcac ctccaccttc ctcaaggcca gacctggctc tgcctgcagc ccagcccagc      480

aggtctggtg aagctggggg ttcactgcgt cacctgccag aaggtggcca tcaagatcgt      540

caaccgtgag aagctcagcg agtcggtgct gatgaaggtg gagcgggaga tcgcgatcct      600

gaagctcatt gagcaccccc acgtcctaaa gctgcacgac gtttatgaaa acaaaaaata      660

tttgtacctg gtgctagaac acgtgtcagg tggtgagctc ttcgactacc tggtgaagaa      720

ggggaggctg acgcctaagg aggctcggaa gttcttccgg cagatcatct ctgcgctgga      780

cttctgccac agccactcca tatgccacag ggatctgaaa cctgaaaacc tcctgctgga      840

cgagaagaac aacatccgca tcgcagactt tggcatggcg tccctgcagg ttggcgacag      900

cctgttggag accagctgtg ggtcccccca ctacgcctgc cccgaggtga tccgggggga      960

gaagtatgac ggccggaagg cggacgtgtg gagctgcggc gtcatcctgt tcgccttgct     1020

ggtgggggct ctgcccttcg acgatgacaa cttgcgacag ctgctggaga aggtgaagcg     1080

gggcgtgttc cacatgccgc actttatccc gcccgactgc cagagtctgc tacggggcat     1140

gatcgaggtg gacgccgcac gccgcctcac gctagagcac attcagaaac acatatggta     1200

tatagggggc aagaatgagc ccgaaccaga gcagcccatt cctcgcaagg tgcagatccg     1260

ctcgctgccc agcctggagg acatcgaccc cgacgtgctg gacagcatgc actcactggg     1320

ctgcttccga gaccgcaaca agctgctgca ggacctgctg tccgaggagg agaaccagga     1380

gaagatgatt tacttcctcc tcctggaccg gaaagaaagg tacccgagcc aggaggatga     1440

ggacctgccc ccccggaacg agatagaccc tccccggaag cgtgtggact ccccgatgct     1500

gaaccggcac ggcaagcggc ggccagaacg caaatccatg gaggtgctca gcgtgacgga     1560

cggcggctcc ccggtgcctg cgcggcgggc cattgagatg gcccagcacg gccagaggtc     1620

tcggtccatc agcggtgcct cctcaggcct ttccaccagc ccactcagca gcccccgggt     1680

gacccctcac ccctcaccaa ggggcagtcc cctccccacc cccaagggga cacctgtcca     1740

cacgccaaag gagagcccgg ctggcacgcc caaccccacg cccccgtcca gccccagcgt     1800

cggaggggtg ccctggaggg cgcggctcaa ctccatcaag aacagctttc tgggctcacc     1860

ccgcttccac cgccggaaac tgcaagttcc gacgccggag gagatgtcca acctgacacc     1920

agagtcgtcc ccagagctgg cgaagaagtc ctggtttggg aacttcatca gcctggagaa     1980

ggaggagcag atcttcgtgg tcatcaaaga caaacctctg agctccatca aggctgacat     2040

cgtgcacgcc ttcctgtcga ttcccagtct cagccacagc gtcatctccc aaacgagctt     2100

ccgggccgag tacaaggcca cgggggggcc agccgtgttc cagaagccgg tcaagttcca     2160

ggttgatatc acctacacgg agggtgggga ggcgcagaag gagaacggca tctactccgt     2220

caccttcacc ctgctctcag gccccagccg tcgcttcaag agggtggtgg agaccatcca     2280

ggcccagctg ctgagcacac acgacccgcc tgcggcccag cacttgtcag acaccactaa     2340

ctgtatggaa atgatgacgg ggcggctttc caaatgtgac gagaagaacg ggcaggcggc     2400

ccaggccccc agcacgcccg ccaagcggag tgcccacggc ccactcggtg actccgcggc     2460

cgctggccct ggccccggag gggacgccga gtacccaacg ggcaaggaca cggccaagat     2520

gggcccgccc accgcccgcc gcgagcagcc ttagacacac tagccccccc ccccagcaca     2580

gcactgacag cggctgcctc gccgcccgcc gcccgccctg ccccgagtgg acccgcggcc     2640

gcgccgcccg tccgtccaga ctgttctcag agcctgggag gaaaggaaag gggcgttggg     2700

gccggcctgt gggctgcgcc acccgcgccc gctctctttt ctctctgtct ctgcctctgc     2760

ctgtctctga cagcatcgct tgtttccact ctgataccag gaattatccc gaaaagttaa     2820

catgtcacct ccacgaggcc atcctctgtg accgaaggca gctgctgcgg acccgccctc     2880

cctccgctcc tgctgttgct gccgggcagt gaggcccagc ccagcgcccc gtccaccccg     2940

cggcagctcc tcgcctcagc tccgcacggc ccgtgggagg aaggccaggc tcgggggagc     3000

ctcctccagc ccggccgacc cggactcccg gtcacctgac ccctcagcaa gaacagcctg     3060

cctggtggcc ttctggggcc aggacccctg gtgggcaacg tagccacagg aacaggcccc     3120

gtccaccgcc tccacgccgc acctggaggc ctcctcgcag gcccgtgccc cgcctccctg     3180

gccgcgccgc ctccgtgtag tcttggcctc ctcaggctgc ctcccgtcct ctcgtctcac     3240

ccgcgcctcc cttgcctcat ctggggcggc tgtgggctct ggcgctcctc tctggctgag     3300

gtggaaacag agacaccctg cggcaccaga gccttcccag caggccaggc cgctgggctg     3360

ggatcagtgt tatttatttg ccgttttaat ttatggattc tccgcacctc tgttcaggga     3420

agggcggcgg ccacatcccc tgccgtctgc gtgtctcagg cagtgggggg gctggggcca     3480

gggcgccctc tgaggacaga gctggtgggg cgcggggggg ctggcgagct actgtaaact     3540

ttaaagaatt cctgcaagat atttttataa actttt                               3576


<210>  6
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Pro Glu Gly His Pro Ser Arg Trp Ala Arg Pro Arg Arg Pro 
1               5                   10                  15      


Cys Ile Cys Pro Ser Ser Leu Cys Ser Pro Arg Glu Pro Arg Ser Gly 
            20                  25                  30          


Pro Ala Val Gly Arg Gly Gly Ala Ala His His Arg Val Pro Ala Gly 
        35                  40                  45              


His Thr Pro Gly Pro Gln Leu Leu Gln Pro His Leu His Leu Pro Gln 
    50                  55                  60                  


Gly Gln Thr Trp Leu Cys Leu Gln Pro Ser Pro Ala Gly Leu Val Lys 
65                  70                  75                  80  


Leu Gly Val His Cys Val Thr Cys Gln Lys Val Ala Ile Lys Ile Val 
                85                  90                  95      


Asn Arg Glu Lys Leu Ser Glu Ser Val Leu Met Lys Val Glu Arg Glu 
            100                 105                 110         


Ile Ala Ile Leu Lys Leu Ile Glu His Pro His Val Leu Lys Leu His 
        115                 120                 125             


Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr Leu Val Leu Glu His Val 
    130                 135                 140                 


Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys Gly Arg Leu Thr 
145                 150                 155                 160 


Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Ile Ser Ala Leu Asp 
                165                 170                 175     


Phe Cys His Ser His Ser Ile Cys His Arg Asp Leu Lys Pro Glu Asn 
            180                 185                 190         


Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala Asp Phe Gly Met 
        195                 200                 205             


Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Thr Ser Cys Gly Ser 
    210                 215                 220                 


Pro His Tyr Ala Cys Pro Glu Val Ile Arg Gly Glu Lys Tyr Asp Gly 
225                 230                 235                 240 


Arg Lys Ala Asp Val Trp Ser Cys Gly Val Ile Leu Phe Ala Leu Leu 
                245                 250                 255     


Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg Gln Leu Leu Glu 
            260                 265                 270         


Lys Val Lys Arg Gly Val Phe His Met Pro His Phe Ile Pro Pro Asp 
        275                 280                 285             


Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Asp Ala Ala Arg Arg 
    290                 295                 300                 


Leu Thr Leu Glu His Ile Gln Lys His Ile Trp Tyr Ile Gly Gly Lys 
305                 310                 315                 320 


Asn Glu Pro Glu Pro Glu Gln Pro Ile Pro Arg Lys Val Gln Ile Arg 
                325                 330                 335     


Ser Leu Pro Ser Leu Glu Asp Ile Asp Pro Asp Val Leu Asp Ser Met 
            340                 345                 350         


His Ser Leu Gly Cys Phe Arg Asp Arg Asn Lys Leu Leu Gln Asp Leu 
        355                 360                 365             


Leu Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr Phe Leu Leu Leu 
    370                 375                 380                 


Asp Arg Lys Glu Arg Tyr Pro Ser Gln Glu Asp Glu Asp Leu Pro Pro 
385                 390                 395                 400 


Arg Asn Glu Ile Asp Pro Pro Arg Lys Arg Val Asp Ser Pro Met Leu 
                405                 410                 415     


Asn Arg His Gly Lys Arg Arg Pro Glu Arg Lys Ser Met Glu Val Leu 
            420                 425                 430         


Ser Val Thr Asp Gly Gly Ser Pro Val Pro Ala Arg Arg Ala Ile Glu 
        435                 440                 445             


Met Ala Gln His Gly Gln Arg Ser Arg Ser Ile Ser Gly Ala Ser Ser 
    450                 455                 460                 


Gly Leu Ser Thr Ser Pro Leu Ser Ser Pro Arg Val Thr Pro His Pro 
465                 470                 475                 480 


Ser Pro Arg Gly Ser Pro Leu Pro Thr Pro Lys Gly Thr Pro Val His 
                485                 490                 495     


Thr Pro Lys Glu Ser Pro Ala Gly Thr Pro Asn Pro Thr Pro Pro Ser 
            500                 505                 510         


Ser Pro Ser Val Gly Gly Val Pro Trp Arg Ala Arg Leu Asn Ser Ile 
        515                 520                 525             


Lys Asn Ser Phe Leu Gly Ser Pro Arg Phe His Arg Arg Lys Leu Gln 
    530                 535                 540                 


Val Pro Thr Pro Glu Glu Met Ser Asn Leu Thr Pro Glu Ser Ser Pro 
545                 550                 555                 560 


Glu Leu Ala Lys Lys Ser Trp Phe Gly Asn Phe Ile Ser Leu Glu Lys 
                565                 570                 575     


Glu Glu Gln Ile Phe Val Val Ile Lys Asp Lys Pro Leu Ser Ser Ile 
            580                 585                 590         


Lys Ala Asp Ile Val His Ala Phe Leu Ser Ile Pro Ser Leu Ser His 
        595                 600                 605             


Ser Val Ile Ser Gln Thr Ser Phe Arg Ala Glu Tyr Lys Ala Thr Gly 
    610                 615                 620                 


Gly Pro Ala Val Phe Gln Lys Pro Val Lys Phe Gln Val Asp Ile Thr 
625                 630                 635                 640 


Tyr Thr Glu Gly Gly Glu Ala Gln Lys Glu Asn Gly Ile Tyr Ser Val 
                645                 650                 655     


Thr Phe Thr Leu Leu Ser Gly Pro Ser Arg Arg Phe Lys Arg Val Val 
            660                 665                 670         


Glu Thr Ile Gln Ala Gln Leu Leu Ser Thr His Asp Pro Pro Ala Ala 
        675                 680                 685             


Gln His Leu Ser Asp Thr Thr Asn Cys Met Glu Met Met Thr Gly Arg 
    690                 695                 700                 


Leu Ser Lys Cys Asp Glu Lys Asn Gly Gln Ala Ala Gln Ala Pro Ser 
705                 710                 715                 720 


Thr Pro Ala Lys Arg Ser Ala His Gly Pro Leu Gly Asp Ser Ala Ala 
                725                 730                 735     


Ala Gly Pro Gly Pro Gly Gly Asp Ala Glu Tyr Pro Thr Gly Lys Asp 
            740                 745                 750         


Thr Ala Lys Met Gly Pro Pro Thr Ala Arg Arg Glu Gln Pro 
        755                 760                 765     


<210>  7
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA

<400>  7
cgatgacatc gacggggaag gac                                               23


<210>  8
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA

<400>  8
gatggcctcg tggaggtgac atg                                               23


<210>  9
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA

<400>  9
gccaccatgg attacaagga tgacgacgat aagacatcga cggggaagga cggcggc          57


<210>  10
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA

<400>  10
gatggcctcg tggaggtgac atg                                               23


<210>  11
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA

<400>  11
ccagaaggtg gccatcatga tcgtcaaccg tgag                                   34


<210>  12
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA

<400>  12
cgccgcacgc cgcctcgcgc tagagcacat tcag                                   34


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA

<400>  13
gtcacctgac ccctcagcaa                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA

<400>  14
caccagctct gtcctcagag                                                   20


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme substrate

<400>  15

Lys Lys Leu Asn Arg Thr Leu Ser Phe Ala Glu Pro Gly 
1               5                   10              


<210>  16
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  16
agcgagagat tgccatcttg a                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  17
gccagagaac ctgctgttgg a                                                 21


<210>  18
<211>  3117
<212>  DNA
<213>  Homo sapiens

<400>  18
tgttcggctc agctgcacgg ctcggctcgg ctcggctcgg ctcggctgcg cggccgctga       60

cgggcgtgcg ctgggggcgc ggggcgcggg gcgcgggcct cggcggcggc ggcggcggcg      120

gcggcggaag ccaggtgccc ccgcccgccc tgtcctctcg acgaggcgga ggcgtcgccg      180

cgggccaggc ctcggactgc cgcgtcggag tggacgcggg gggcggcggc gcgggcggac      240

gcgggcggcg cgaagcagcg gggcccgcgg gggcgccccg gccgggtcgg cgcggacggc      300

actcggcgga cgcgggcgga cgctgggcgg cccctccctg cccgcgcgcc cgggcgcccc      360

tggccggcgc tgggccccag agcgatgaca tcgacgggga aggacggcgg cgcgcagcac      420

gcgcagtatg ttgggcccta ccggctggag aagacgctgg gcaaggggca gacaggtctg      480

gtgaagctgg gggttcactg cgtcacctgc cagaaggtgg ccatcaagat cgtcaaccgt      540

gagaagctca gcgagtcggt gctgatgaag gtggagcggg agatcgcgat cctgaagctc      600

attgagcacc cccacgtcct aaagctgcac gacgtttatg aaaacaaaaa atatttgtac      660

ctggtgctag aacacgtgtc aggtggtgag ctcttcgact acctggtgaa gaaggggagg      720

ctgacgccta aggaggctcg gaagttcttc cggcagatca tctctgcgct ggacttctgc      780

cacagccact ccatatgcca cagggatctg aaacctgaaa acctcctgct ggacgagaag      840

aacaacatcc gcatcgcaga ctttggcatg gcgtccctgc aggttggcga cagcctgttg      900

gagaccagct gtgggtcccc ccactacgcc tgccccgagg tgatccgggg ggagaagtat      960

gacggccgga aggcggacgt gtggagctgc ggcgtcatcc tgttcgcctt gctggtgggg     1020

gctctgccct tcgacgatga caacttgcga cagctgctgg agaaggtgaa gcggggcgtg     1080

ttccacatgc cgcactttat cccgcccgac tgccagagtc tgctacgggg catgagcgag     1140

gtggacgccg cacgccgcct cacgctagag cacattcaga aacacatatg gtatataggg     1200

ggcaagaatg agcccgaacc agagcagccc attcctcgca aggtgcagat ccgctcgctg     1260

cccagcctgg aggacatcga ccccgacgtg ctggacagca tgcactcact gggctgcttc     1320

cgagaccgca acaagctgct gcaggacctg ctgtccgagg aggagaacca ggagaagatg     1380

atttacttcc tcctcctgga ccggaaagaa aggtacccga gccaggagga tgaggacctg     1440

cccccccgga acgagataga ccctccccgg aagcgtgtgg actccccgat gctgaaccgg     1500

cacggcaagc ggcggccaga acgcaaatcc atggaggtgc tcagcgtgac ggacggcggc     1560

tccccggtgc ctgcgcggcg ggccattgag atggcccagc acggccagag gtctcggtcc     1620

atcagcggtg cctcctcagg cctttccacc agcccactca gcagcccccg ggtgacccct     1680

cacccctcac caaggggcag tcccctcccc acccccaagg ggacacctgt ccacacgcca     1740

aaggagagcc cggctggcac gcccaacccc acgcccccgt ccagccccag cgtcggaggg     1800

gtgccctgga gggcgcggct caactccatc aagaacagct ttctgggctc accccgcttc     1860

caccgccgaa aactgcaagt tccgacgccg gaggagatgt ccaacctgac accagagtcg     1920

tccccagagc tggcgaagaa gtcctggttt gggaacttca tcagcctgga gaaggaggag     1980

cagatcttcg tggtcatcaa agacaaacct ctgagctcca tcaaggctga catcgtgcac     2040

gccttcctgt cgattcccag tctcagccac agcgtcatct cccaaacgag cttccgggcc     2100

gagtacaagg ccacgggggg gccagccgtg ttccagaagc cggtcaagtt ccaggttgat     2160

atcacctaca cggagggtgg ggaggcgcag aaggagaacg gcatctactc cgtcaccttc     2220

accctgctct caggccccag ccgtcgcttc aagagggtgg tggagaccat ccaggcccag     2280

ctgctgagca cacacgaccc gcctgcggcc cagcacttgt cagacaccac taactgtatg     2340

gaaatgatga cggggcggct ttccaaatgt ggaattatcc cgaaaagtta acatgtcacc     2400

tccacgaggc catcctctgt gaccgaaggc agctgctgcg gacccgccct ccctccgctc     2460

ctgctgttgc tgccgggcag tgaggcccag cccagcgccc cgtccacccc gcggcagctc     2520

ctcgcctcag ctccgcacgg cccgtgggag gaaggccagg ctcgggggag cctcctccag     2580

cccggccgac ccggactccc ggtcacctga cccctcagca agaacagcct gcctggtggc     2640

cttctggggc caggaccccc ggtgggcaac gtagccacag gaacaggccc cgtccaccgc     2700

ctccacgccg cacctggagg cctcctgcag gcccgtgccc cgcctccctg gccgcgccgc     2760

ctccgtgtag tcttggcctc ctcaggctgc ctcccgtcct ctcgtctcac ccgcgcctcc     2820

cttgcctcat ctggggaggc tgtgggctct ggcgctcctc tctggctgag gtggaaacag     2880

agacaccctg cggcaccaga gccttcccag caggccaggc cgctgggctg ggatcagtgt     2940

tatttatttg ccgttttcca atttatggat tctccgcacc tctgttcagg gaagggcggc     3000

ggccacatcc cctgccgtct gcgtgtctca ggcagtgggg gggctggggc cagggcgccc     3060

tctgaggaca gagctggtgg ggcgcggggg ggctggcgag ctactgtaaa ctttaaa        3117


<210>  19
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Thr Ser Thr Gly Lys Asp Gly Gly Ala Gln His Ala Gln Tyr Val 
1               5                   10                  15      


Gly Pro Tyr Arg Leu Glu Lys Thr Leu Gly Lys Gly Gln Thr Gly Leu 
            20                  25                  30          


Val Lys Leu Gly Val His Cys Val Thr Cys Gln Lys Val Ala Ile Lys 
        35                  40                  45              


Ile Val Asn Arg Glu Lys Leu Ser Glu Ser Val Leu Met Lys Val Glu 
    50                  55                  60                  


Arg Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro His Val Leu Lys 
65                  70                  75                  80  


Leu His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr Leu Val Leu Glu 
                85                  90                  95      


His Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys Gly Arg 
            100                 105                 110         


Leu Thr Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Ile Ser Ala 
        115                 120                 125             


Leu Asp Phe Cys His Ser His Ser Ile Cys His Arg Asp Leu Lys Pro 
    130                 135                 140                 


Glu Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala Asp Phe 
145                 150                 155                 160 


Gly Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Thr Ser Cys 
                165                 170                 175     


Gly Ser Pro His Tyr Ala Cys Pro Glu Val Ile Arg Gly Glu Lys Tyr 
            180                 185                 190         


Asp Gly Arg Lys Ala Asp Val Trp Ser Cys Gly Val Ile Leu Phe Ala 
        195                 200                 205             


Leu Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg Gln Leu 
    210                 215                 220                 


Leu Glu Lys Val Lys Arg Gly Val Phe His Met Pro His Phe Ile Pro 
225                 230                 235                 240 


Pro Asp Cys Gln Ser Leu Leu Arg Gly Met Ser Glu Val Asp Ala Ala 
                245                 250                 255     


Arg Arg Leu Thr Leu Glu His Ile Gln Lys His Ile Trp Tyr Ile Gly 
            260                 265                 270         


Gly Lys Asn Glu Pro Glu Pro Glu Gln Pro Ile Pro Arg Lys Val Gln 
        275                 280                 285             


Ile Arg Ser Leu Pro Ser Leu Glu Asp Ile Asp Pro Asp Val Leu Asp 
    290                 295                 300                 


Ser Met His Ser Leu Gly Cys Phe Arg Asp Arg Asn Lys Leu Leu Gln 
305                 310                 315                 320 


Asp Leu Leu Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr Phe Leu 
                325                 330                 335     


Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Gln Glu Asp Glu Asp Leu 
            340                 345                 350         


Pro Pro Arg Asn Glu Ile Asp Pro Pro Arg Lys Arg Val Asp Ser Pro 
        355                 360                 365             


Met Leu Asn Arg His Gly Lys Arg Arg Pro Glu Arg Lys Ser Met Glu 
    370                 375                 380                 


Val Leu Ser Val Thr Asp Gly Gly Ser Pro Val Pro Ala Arg Arg Ala 
385                 390                 395                 400 


Ile Glu Met Ala Gln His Gly Gln Arg Ser Arg Ser Ile Ser Gly Ala 
                405                 410                 415     


Ser Ser Gly Leu Ser Thr Ser Pro Leu Ser Ser Pro Arg Val Thr Pro 
            420                 425                 430         


His Pro Ser Pro Arg Gly Ser Pro Leu Pro Thr Pro Lys Gly Thr Pro 
        435                 440                 445             


Val His Thr Pro Lys Glu Ser Pro Ala Gly Thr Pro Asn Pro Thr Pro 
    450                 455                 460                 


Pro Ser Ser Pro Ser Val Gly Gly Val Pro Trp Arg Ala Arg Leu Asn 
465                 470                 475                 480 


Ser Ile Lys Asn Ser Phe Leu Gly Ser Pro Arg Phe His Arg Arg Lys 
                485                 490                 495     


Leu Gln Val Pro Thr Pro Glu Glu Met Ser Asn Leu Thr Pro Glu Ser 
            500                 505                 510         


Ser Pro Glu Leu Ala Lys Lys Ser Trp Phe Gly Asn Phe Ile Ser Leu 
        515                 520                 525             


Glu Lys Glu Glu Gln Ile Phe Val Val Ile Lys Asp Lys Pro Leu Ser 
    530                 535                 540                 


Ser Ile Lys Ala Asp Ile Val His Ala Phe Leu Ser Ile Pro Ser Leu 
545                 550                 555                 560 


Ser His Ser Val Ile Ser Gln Thr Ser Phe Arg Ala Glu Tyr Lys Ala 
                565                 570                 575     


Thr Gly Gly Pro Ala Val Phe Gln Lys Pro Val Lys Phe Gln Val Asp 
            580                 585                 590         


Ile Thr Tyr Thr Glu Gly Gly Glu Ala Gln Lys Glu Asn Gly Ile Tyr 
        595                 600                 605             


Ser Val Thr Phe Thr Leu Leu Ser Gly Pro Ser Arg Arg Phe Lys Arg 
    610                 615                 620                 


Val Val Glu Thr Ile Gln Ala Gln Leu Leu Ser Thr His Asp Pro Pro 
625                 630                 635                 640 


Ala Ala Gln His Leu Ser Asp Thr Thr Asn Cys Met Glu Met Met Thr 
                645                 650                 655     


Gly Arg Leu Ser Lys Cys Gly Ile Ile Pro Lys Ser 
            660                 665             




29


