                               SEQUENCE LISTING                               

<110> GENENTECH, INC.
      HASS, PHILLIP
      JIANPING, YIN
      KATSCHKE, KENNETH JR.
      STEFFEK, MICAH
      WIESMANN, CHRIS
      VAN LOOKEREN CAMPAGNE, MENNO

<120> PREVENTION AND TREATMENT OF COMPLEMENT-ASSOCIATED EYE
      CONDITIONS

<130> GNE-0244 PCT

<140> Not yet Assigned
<141> Herewith

<150> 60/939,791
<151> 2007-05-23

<160> 7                             

<170> PatentIn Ver. 3.3

<210> 1
<211> 233
<212> PRT
<213> Mus musculus

<400> 1
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly  
  1               5                  10                  15    

Val His Ser Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr  
             20                  25                  30        

Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val  
         35                  40                  45            

Asp Thr Asp Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Arg  
     50                  55                  60                

Gly Leu Ile Tyr Ser Ala Ser Ser Arg Tyr Ser Gly Val Pro Asp Arg  
 65                  70                  75                  80

Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn  
                 85                  90                  95    

Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Asn  
            100                 105                 110        

Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Arg Thr  
        115                 120                 125            

Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu  
    130                 135                 140                

Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro  
145                 150                 155                 160

Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly  
                165                 170                 175    

Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr  
            180                 185                 190        

Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His  
        195                 200                 205            

Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val  
    210                 215                 220                

Thr Lys Ser Phe Asn Arg Gly Glu Cys                              
225                 230            


<210> 2
<211> 464
<212> PRT
<213> Mus musculus

<400> 2
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly  
  1               5                  10                  15    

Ala Tyr Ala Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys  
             20                  25                  30        

Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe  
         35                  40                  45            

Thr Ser Tyr Tyr Met Tyr Trp Val Lys Glu Arg Pro Gly Gln Gly Leu  
     50                  55                  60                

Glu Trp Ile Gly Glu Ile Asn Pro Thr Asn Gly Gly Thr Asn Phe Asn  
 65                  70                  75                  80

Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn  
                 85                  90                  95    

Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val  
            100                 105                 110        

Tyr Tyr Cys Ala Arg Glu Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr  
        115                 120                 125            

Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro  
    130                 135                 140                

Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly  
145                 150                 155                 160

Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn  
                165                 170                 175    

Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln  
            180                 185                 190        

Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser  
        195                 200                 205            

Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser  
    210                 215                 220                

Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr  
225                 230                 235                 240

His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser  
                245                 250                 255    

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg  
            260                 265                 270        

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro  
        275                 280                 285            

Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala  
    290                 295                 300                

Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val  
305                 310                 315                 320

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr  
                325                 330                 335    

Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr  
            340                 345                 350        

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu  
        355                 360                 365            

Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys  
    370                 375                 380                

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser  
385                 390                 395                 400

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp  
                405                 410                 415    

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser  
            420                 425                 430        

Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala  
        435                 440                 445            

Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys  
    450                 455                 460                

                                                                 



<210> 3
<211> 259
<212> PRT
<213> Homo sapiens

<400> 3
Met His Ser Ser Val Tyr Phe Val Ala Leu Val Ile Leu Gly Ala Ala  
  1               5                  10                  15    

Val Cys Ala Ala Gln Pro Arg Gly Arg Ile Leu Gly Gly Gln Glu Ala  
             20                  25                  30        

Ala Ala His Ala Arg Pro Tyr Met Ala Ser Val Gln Val Asn Gly Thr  
         35                  40                  45            

His Val Cys Gly Gly Thr Leu Leu Asp Glu Gln Trp Val Leu Ser Ala  
     50                  55                  60                

Ala His Cys Met Asp Gly Val Thr Asp Asp Asp Ser Val Gln Val Leu  
 65                  70                  75                  80

Leu Gly Ala His Ser Leu Ser Ala Pro Glu Pro Tyr Lys Arg Trp Tyr  
                 85                  90                  95    

Asp Val Gln Ser Val Val Pro His Pro Gly Ser Arg Pro Asp Ser Leu  
            100                 105                 110        

Glu Asp Asp Leu Ile Leu Phe Lys Leu Ser Gln Asn Ala Ser Leu Gly  
        115                 120                 125            

Pro His Val Arg Pro Leu Pro Leu Gln Tyr Glu Asp Lys Glu Val Glu  
    130                 135                 140                

Pro Gly Thr Leu Cys Asp Val Ala Gly Trp Gly Val Val Thr His Ala  
145                 150                 155                 160

Gly Arg Arg Pro Asp Val Leu His Gln Leu Arg Val Ser Ile Met Asn  
                165                 170                 175    

Arg Thr Thr Cys Asn Leu Arg Thr Tyr His Asp Gly Val Val Thr Ile  
            180                 185                 190        

Asn Met Met Cys Ala Glu Ser Asn Arg Arg Asp Thr Cys Arg Gly Asp  
        195                 200                 205            

Ser Gly Ser Pro Leu Val Cys Gly Asp Ala Val Glu Gly Val Val Thr  
    210                 215                 220                

Trp Gly Ser Arg Val Cys Gly Asn Gly Lys Lys Pro Gly Val Tyr Thr  
225                 230                 235                 240

Arg Val Ser Ser Tyr Arg Met Trp Ile Glu Asn Ile Thr Asn Gly Asn  
                245                 250                 255    

Met Thr Ser                                                      
           


<210> 4
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 4
gatcgatatc gtratgachc artctca                                     27    


<210> 5
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 5
tttdakytcc agcttggtac c                                           21    


<210> 6
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
gatccgtacg ctcaggtyca rytgcarcar tctgg                            35    


<210> 7
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
acagtgggcc cttggtggag gctgmrgaga cdgtgashrd rgt                   43    


