                                SEQUENCE LISTING

<110> CENTOCOR, INC.

<120> TOLL LIKE RECEPTOR 3 MODULATORS AND USES
  THEREOF

<130> CEN5183PCT

<140> To Be Assigned
<141> 2008-05-23

<140> 60/940,196    
<141> 2007-05-25  

<160> 24

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 904
<212> PRT
<213> Homo sapiens

<400> 1
Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro
 1               5                  10                  15      
Phe Gly Met Leu Cys Ala Ser Ser Thr Thr Lys Cys Thr Val Ser His
            20                  25                  30          
Glu Val Ala Asp Cys Ser His Leu Lys Leu Thr Gln Val Pro Asp Asp
        35                  40                  45              
Leu Pro Thr Asn Ile Thr Val Leu Asn Leu Thr His Asn Gln Leu Arg
    50                  55                  60                  
Arg Leu Pro Ala Ala Asn Phe Thr Arg Tyr Ser Gln Leu Thr Ser Leu
65                  70                  75                  80  
Asp Val Gly Phe Asn Thr Ile Ser Lys Leu Glu Pro Glu Leu Cys Gln
                85                  90                  95      
Lys Leu Pro Met Leu Lys Val Leu Asn Leu Gln His Asn Glu Leu Ser
            100                 105                 110         
Gln Leu Ser Asp Lys Thr Phe Ala Phe Cys Thr Asn Leu Thr Glu Leu
        115                 120                 125             
His Leu Met Ser Asn Ser Ile Gln Lys Ile Lys Asn Asn Pro Phe Val
    130                 135                 140                 
Lys Gln Lys Asn Leu Ile Thr Leu Asp Leu Ser His Asn Gly Leu Ser
145                 150                 155                 160 
Ser Thr Lys Leu Gly Thr Gln Val Gln Leu Glu Asn Leu Gln Glu Leu
                165                 170                 175     
Leu Leu Ser Asn Asn Lys Ile Gln Ala Leu Lys Ser Glu Glu Leu Asp
            180                 185                 190         
Ile Phe Ala Asn Ser Ser Leu Lys Lys Leu Glu Leu Ser Ser Asn Gln
        195                 200                 205             
Ile Lys Glu Phe Ser Pro Gly Cys Phe His Ala Ile Gly Arg Leu Phe
    210                 215                 220                 
Gly Leu Phe Leu Asn Asn Val Gln Leu Gly Pro Ser Leu Thr Glu Lys
225                 230                 235                 240 
Leu Cys Leu Glu Leu Ala Asn Thr Ser Ile Arg Asn Leu Ser Leu Ser
                245                 250                 255     
Asn Ser Gln Leu Ser Thr Thr Ser Asn Thr Thr Phe Leu Gly Leu Lys
            260                 265                 270         
Trp Thr Asn Leu Thr Met Leu Asp Leu Ser Tyr Asn Asn Leu Asn Val
        275                 280                 285             
Val Gly Asn Asp Ser Phe Ala Trp Leu Pro Gln Leu Glu Tyr Phe Phe
    290                 295                 300                 
Leu Glu Tyr Asn Asn Ile Gln His Leu Phe Ser His Ser Leu His Gly
305                 310                 315                 320 
Leu Phe Asn Val Arg Tyr Leu Asn Leu Lys Arg Ser Phe Thr Lys Gln
                325                 330                 335     
Ser Ile Ser Leu Ala Ser Leu Pro Lys Ile Asp Asp Phe Ser Phe Gln
            340                 345                 350         
Trp Leu Lys Cys Leu Glu His Leu Asn Met Glu Asp Asn Asp Ile Pro
        355                 360                 365             
Gly Ile Lys Ser Asn Met Phe Thr Gly Leu Ile Asn Leu Lys Tyr Leu
    370                 375                 380                 
Ser Leu Ser Asn Ser Phe Thr Ser Leu Arg Thr Leu Thr Asn Glu Thr
385                 390                 395                 400 
Phe Val Ser Leu Ala His Ser Pro Leu His Ile Leu Asn Leu Thr Lys
                405                 410                 415     
Asn Lys Ile Ser Lys Ile Glu Ser Asp Ala Phe Ser Trp Leu Gly His
            420                 425                 430         
Leu Glu Val Leu Asp Leu Gly Leu Asn Glu Ile Gly Gln Glu Leu Thr
        435                 440                 445             
Gly Gln Glu Trp Arg Gly Leu Glu Asn Ile Phe Glu Ile Tyr Leu Ser
    450                 455                 460                 
Tyr Asn Lys Tyr Leu Gln Leu Thr Arg Asn Ser Phe Ala Leu Val Pro
465                 470                 475                 480 
Ser Leu Gln Arg Leu Met Leu Arg Arg Val Ala Leu Lys Asn Val Asp
                485                 490                 495     
Ser Ser Pro Ser Pro Phe Gln Pro Leu Arg Asn Leu Thr Ile Leu Asp
            500                 505                 510         
Leu Ser Asn Asn Asn Ile Ala Asn Ile Asn Asp Asp Met Leu Glu Gly
        515                 520                 525             
Leu Glu Lys Leu Glu Ile Leu Asp Leu Gln His Asn Asn Leu Ala Arg
    530                 535                 540                 
Leu Trp Lys His Ala Asn Pro Gly Gly Pro Ile Tyr Phe Leu Lys Gly
545                 550                 555                 560 
Leu Ser His Leu His Ile Leu Asn Leu Glu Ser Asn Gly Phe Asp Glu
                565                 570                 575     
Ile Pro Val Glu Val Phe Lys Asp Leu Phe Glu Leu Lys Ile Ile Asp
            580                 585                 590         
Leu Gly Leu Asn Asn Leu Asn Thr Leu Pro Ala Ser Val Phe Asn Asn
        595                 600                 605             
Gln Val Ser Leu Lys Ser Leu Asn Leu Gln Lys Asn Leu Ile Thr Ser
    610                 615                 620                 
Val Glu Lys Lys Val Phe Gly Pro Ala Phe Arg Asn Leu Thr Glu Leu
625                 630                 635                 640 
Asp Met Arg Phe Asn Pro Phe Asp Cys Thr Cys Glu Ser Ile Ala Trp
                645                 650                 655     
Phe Val Asn Trp Ile Asn Glu Thr His Thr Asn Ile Pro Glu Leu Ser
            660                 665                 670         

Ser His Tyr Leu Cys Asn Thr Pro Pro His Tyr His Gly Phe Pro Val
        675                 680                 685             
Arg Leu Phe Asp Thr Ser Ser Cys Lys Asp Ser Ala Pro Phe Glu Leu
    690                 695                 700                 
Phe Phe Met Ile Asn Thr Ser Ile Leu Leu Ile Phe Ile Phe Ile Val
705                 710                 715                 720 
Leu Leu Ile His Phe Glu Gly Trp Arg Ile Ser Phe Tyr Trp Asn Val
                725                 730                 735     
Ser Val His Arg Val Leu Gly Phe Lys Glu Ile Asp Arg Gln Thr Glu
            740                 745                 750         
Gln Phe Glu Tyr Ala Ala Tyr Ile Ile His Ala Tyr Lys Asp Lys Asp
        755                 760                 765             
Trp Val Trp Glu His Phe Ser Ser Met Glu Lys Glu Asp Gln Ser Leu
    770                 775                 780                 
Lys Phe Cys Leu Glu Glu Arg Asp Phe Glu Ala Gly Val Phe Glu Leu
785                 790                 795                 800 
Glu Ala Ile Val Asn Ser Ile Lys Arg Ser Arg Lys Ile Ile Phe Val
                805                 810                 815     
Ile Thr His His Leu Leu Lys Asp Pro Leu Cys Lys Arg Phe Lys Val
            820                 825                 830         
His His Ala Val Gln Gln Ala Ile Glu Gln Asn Leu Asp Ser Ile Ile
        835                 840                 845             
Leu Val Phe Leu Glu Glu Ile Pro Asp Tyr Lys Leu Asn His Ala Leu
    850                 855                 860                 
Cys Leu Arg Arg Gly Met Phe Lys Ser His Cys Ile Leu Asn Trp Pro
865                 870                 875                 880 
Val Gln Lys Glu Arg Ile Gly Ala Phe Arg His Lys Leu Gln Val Ala
                885                 890                 895     
Leu Gly Ser Lys Asn Ser Val His
            900                 


<210> 2
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphorothioate backbone

<400> 2
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 3
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphorothioate backbone

<400> 3
tgctgctttt gtgcttttgt gctt                                        24

<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> mixed phosphodiester(nt 3-14)/phosphorothioate(nt 1-2,15-20) backbone 

<400> 4
gggggacgat cgtcgggggg                                             20

<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> mixed phosphodiester(nt 3-14)/phosphorothioate(nt 1-2,15-20) backbone

<400> 5
gggggagcat gctggggggc                                             20

<210> 6
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphodiester backbone

<400> 6
gtcgacaagg gattgaacct cgttc                                       25

<210> 7
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphodiester backbone

<400> 7
tacgtactta gatatgtctt caaaccatac                                  30

<210> 8
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphodiester backbone

<400> 8
ggcttcactt tcatagactg caacggtgcc tgaaag                           36

<210> 9
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphodiester backbone

<400> 9
gctctagatt aagatttacc gatgtcgctc actaaggacc                       40

<210> 10
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphodiester backbone

<400> 10
aaagtgtgtc actgccagtg tgcaaggata gactggacag cagcccgctg ctgt       54

<210> 11
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphodiester backbone

<400> 11
ctcgagcaga ggtctcacac agagacaagc gcatcagtca acagagatcc cttgcgcttc 60


<210> 12
<211> 75
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphodiester backbone

<400> 12
gtcgaccacg gttctgctac ttgttctttg tttttcacca acaaaatggt atggtttgaa 60
gacatatcta agtac                                                  75

<210> 13
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphodiester backbone
<400> 13
acaaacataa cagtgttggc ccttacccat aatcaactc                        39

<210> 14
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphodiester backbone

<400> 14
cataacagtg ttggccctta cccataatca actc                             34

<210> 15
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphodiester backbone

<400> 15
cagtgttggc ccttacccat aatcaactc                                   29

<210> 16
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphodiester backbone

<400> 16
ttggccctta cccataatca actc                                        24

<210> 17
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphodiester backbone

<400> 17
ccttacccat aatcaactc                                              19

<210> 18
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphodiester backbone

<400> 18
acaaacataa cagtgttggc ccttacccat aatc                             34

<210> 19
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphodiester backbone

<400> 19
acaaacataa cagtgttggc ccttaccca                                   29

<210> 20
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphodiester backbone

<400> 20
acaaacataa cagtgttggc cctt                                        24

<210> 21
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> phosphodiester backbone

<400> 21
acaaacataa cagtgttgg                                              19

<210> 22
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> mixed phosphodiester(nt 1-6,31-36)/phosphorothioate(nt7-30) backbone

<400> 22
ccgccctcgt cgttttgtcg ttttgtcgtt gggcgg                           36

<210> 23
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> mixed phosphodiester(nt 1-6,27-32)/phosphorothioate(nt7-26) backbone

<400> 23
ccgccctttt tttttttttt ttttttgggc gg                               32

<210> 24
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> mixed phosphodiester(nt1-6,27-32)/phosphorothioate(nt7-26) backbone

<400> 24
ccgcccaaaa aaaaaaaaaa aaaaaagggc gg                               32
CEN5183PCT




2


