                               SEQUENCE LISTING                               

<110> ABBOTT LABORATORIES

<120> HUMANIZED ANTIBODIES TO ABETA(20-42) GLOBULOMER AND
      USES THEREOF

<130> 8907USL2

<140>
<141>

<150> PCT/US06/046148
<151> 2006-11-30

<150> 60/940,932
<151> 2007-05-30

<160> 73                            

<170> PatentIn Ver. 3.3

<210> 1
<211> 120
<212> PRT
<213> Homo sapiens

<400> 1
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala  
  1               5                  10                  15    

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Phe  
             20                  25                  30        

Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile  
         35                  40                  45            

Gly Met Ile Gly Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Met Phe  
     50                  55                  60                

Lys Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr  
 65                  70                  75                  80

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                 85                  90                  95    

Ala Arg Ala Lys Ser Ala Arg Ala Ala Trp Phe Ala Tyr Trp Gly Gln  
            100                 105                 110        

Gly Thr Leu Val Thr Val Ser Ser                                  
        115                 120


<210> 2
<211> 113
<212> PRT
<213> Homo sapiens

<400> 2
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Val Val Gln Ser  
             20                  25                  30        

Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser  
         35                  40                  45            

Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro  
     50                  55                  60                

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile  
 65                  70                  75                  80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly  
                 85                  90                  95    

Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys  
            100                 105                 110        

Arg                                                              
   


<210> 3
<211> 118
<212> PRT
<213> Homo sapiens

<400> 3
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly  
  1               5                  10                  15    

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr  
             20                  25                  30        

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val  
         35                  40                  45            

Ala Ser Ile His Asn Arg Gly Thr Ile Phe Tyr Leu Asp Ser Val Lys  
     50                  55                  60                

Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Arg Asn Thr Leu Tyr Leu  
 65                  70                  75                  80

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr  
                 85                  90                  95    

Arg Gly Arg Ser Asn Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr  
            100                 105                 110        

Ser Val Thr Val Ser Ser                                          
        115            


<210> 4
<211> 113
<212> PRT
<213> Homo sapiens

<400> 4
Asp Val Leu Val Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Gln Thr Leu Val His Arg  
             20                  25                  30        

Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser  
         35                  40                  45            

Pro Gln Ser Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro  
     50                  55                  60                

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile  
 65                  70                  75                  80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly  
                 85                  90                  95    

Ser His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys  
            100                 105                 110        

Arg                                                              
   


<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<221> MOD_RES
<222> (1)
<223> Thr or Ser

<220>
<221> MOD_RES
<222> (2)
<223> Phe or Tyr

<220>
<221> MOD_RES
<222> (3)
<223> Tyr or Ala

<220>
<221> MOD_RES
<222> (4)
<223> Ile or Met

<220>
<221> MOD_RES
<222> (5)
<223> His or Ser

<220>
<221> MOD_RES
<222> (6)
<223> any amino acid

<220>
<221> MOD_RES
<222> (7)
<223> any amino acid

<400> 5
Xaa Xaa Xaa Xaa Xaa Xaa Xaa                                      
  1               5        


<210> 6
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<221> MOD_RES
<222> (1)
<223> Met or Ser

<220>
<221> MOD_RES
<222> (3)
<223> Gly or His

<220>
<221> MOD_RES
<222> (4)
<223> Pro or Asn

<220>
<221> MOD_RES
<222> (5)
<223> Gly or Arg

<220>
<221> MOD_RES
<222> (6)
<223> Ser or Gly

<220>
<221> MOD_RES
<222> (7)
<223> Gly or Thr

<220>
<221> MOD_RES
<222> (8)
<223> Asn or Ile

<220>
<221> MOD_RES
<222> (9)
<223> Thr or Phe

<220>
<221> MOD_RES
<222> (11)
<223> Tyr or Leu

<220>
<221> MOD_RES
<222> (12)
<223> Asn or Asp

<220>
<221> MOD_RES
<222> (13)
<223> Glu or Ser

<220>
<221> MOD_RES
<222> (14)
<223> Met or Val

<220>
<221> MOD_RES
<222> (15)
<223> Phe or Lys

<220>
<221> MOD_RES
<222> (16)
<223> Lys or Gly

<220>
<221> MOD_RES
<222> (17)
<223> Asp or not present

<400> 6
Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Xaa Xaa Xaa  
  1               5                  10                  15    

Xaa                                                              
   


<210> 7
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide
<220>
<221> MOD_RES
<222> (1)
<223> Ala or Gly

<220>
<221> MOD_RES
<222> (2)
<223> Lys or Arg

<220>
<221> MOD_RES
<222> (4)
<223> Ala or Asn

<220>
<221> MOD_RES
<222> (5)
<223> Arg or Ser

<220>
<221> MOD_RES
<222> (6)
<223> Ala or Tyr

<220>
<221> MOD_RES
<222> (8)
<223> Trp or Met

<220>
<221> MOD_RES
<222> (9)
<223> Phe or Asp

<220>
<221> MOD_RES
<222> (10)
<223> Ala or Tyr

<220>
<221> MOD_RES
<222> (11)
<223> Tyr or not present

<220>
<221> MOD_RES
<222> (12)
<223> any amino acid

<220>
<221> MOD_RES
<222> (13)
<223> any amino acid

<400> 7
Xaa Xaa Ser Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa              
  1               5                  10            


<210> 8
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<221> MOD_RES
<222> (3)
<223> Ser or Thr

<220>
<221> MOD_RES
<222> (5)
<223> Ser or Thr

<220>
<221> MOD_RES
<222> (6)
<223> Val or Leu

<220>
<221> MOD_RES
<222> (8)
<223> Gln or His

<220>
<221> MOD_RES
<222> (9)
<223> Ser or Arg

<220>
<221> MOD_RES
<222> (12)
<223> Asn or Asp

<220>
<221> MOD_RES
<222> (15)
<223> Asn or Leu

<400> 8
Arg Ser Xaa Gln Xaa Xaa Val Xaa Xaa Asn Gly Xaa Thr Tyr Xaa Glu 
  1               5                  10                  15    


<210> 9
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<221> MOD_RES
<222> (8)
<223> any amino acid

<400> 9
Lys Val Ser Asn Arg Phe Ser Xaa                                  
  1               5            


<210> 10
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<221> MOD_RES
<222> (8)
<223> Pro or Tyr

<400> 10
Phe Gln Gly Ser His Val Pro Xaa Thr                              
  1               5                


<210> 11
<211> 5
<212> PRT
<213> Homo sapiens

<400> 11
Thr Phe Tyr Ile His                                              
  1               5


<210> 12
<211> 17
<212> PRT
<213> Homo sapiens

<400> 12
Met Ile Gly Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Met Phe Lys  
  1               5                  10                  15    

Asp                                                              
   


<210> 13
<211> 11
<212> PRT
<213> Homo sapiens

<400> 13
Ala Lys Ser Ala Arg Ala Ala Trp Phe Ala Tyr                      
  1               5                  10    


<210> 14
<211> 16
<212> PRT
<213> Homo sapiens

<400> 14
Arg Ser Ser Gln Ser Val Val Gln Ser Asn Gly Asn Thr Tyr Leu Glu  
  1               5                  10                  15    


<210> 15
<211> 7
<212> PRT
<213> Homo sapiens

<400> 15
Lys Val Ser Asn Arg Phe Ser                                      
  1               5        


<210> 16
<211> 5
<212> PRT
<213> Homo sapiens

<400> 16
Ser Tyr Ala Met Ser                                              
  1               5


<210> 17
<211> 16
<212> PRT
<213> Homo sapiens

<400> 17
Ser Ile His Asn Arg Gly Thr Ile Phe Tyr Leu Asp Ser Val Lys Gly  
  1               5                  10                  15    


<210> 18
<211> 10
<212> PRT
<213> Homo sapiens

<400> 18
Gly Arg Ser Asn Ser Tyr Ala Met Asp Tyr                          
  1               5                  10


<210> 19
<211> 16
<212> PRT
<213> Homo sapiens

<400> 19
Arg Ser Thr Gln Thr Leu Val His Arg Asn Gly Asp Thr Tyr Leu Glu  
  1               5                  10                  15    


<210> 20
<211> 7
<212> PRT
<213> Homo sapiens

<400> 20
Lys Val Ser Asn Arg Phe Ser                                      
  1               5        


<210> 21
<211> 9
<212> PRT
<213> Homo sapiens

<400> 21
Phe Gln Gly Ser His Val Pro Tyr Thr                              
  1               5                


<210> 22
<211> 30
<212> PRT
<213> Homo sapiens

<400> 22
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala  
  1               5                  10                  15    

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr          
             20                  25                  30


<210> 23
<211> 13
<212> PRT
<213> Homo sapiens

<400> 23
Trp Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly              
  1               5                  10            


<210> 24
<211> 32
<212> PRT
<213> Homo sapiens

<400> 24
Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu  
  1               5                  10                  15    

Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg  
             20                  25                  30        

                                                                 



<210> 25
<211> 11
<212> PRT
<213> Homo sapiens

<400> 25
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                      
  1               5                  10    


<210> 26
<211> 23
<212> PRT
<213> Homo sapiens

<400> 26
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys                                      
             20            


<210> 27
<211> 15
<212> PRT
<213> Homo sapiens

<400> 27
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr      
  1               5                  10                  15


<210> 28
<211> 31
<212> PRT
<213> Homo sapiens

<400> 28
Gly Val Pro Asp Arg Phe Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu  
  1               5                  10                  15    

Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys      
             20                  25                  30    


<210> 29
<211> 11
<212> PRT
<213> Homo sapiens

<400> 29
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg                      
  1               5                  10    


<210> 30
<211> 30
<212> PRT
<213> Homo sapiens

<400> 30
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly  
  1               5                  10                  15    

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser          
             20                  25                  30


<210> 31
<211> 14
<212> PRT
<213> Homo sapiens

<400> 31
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser          
  1               5                  10                


<210> 32
<211> 32
<212> PRT
<213> Homo sapiens

<400> 32
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln  
  1               5                  10                  15    

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg  
             20                  25                  30        

                                                                 



<210> 33
<211> 11
<212> PRT
<213> Homo sapiens

<400> 33
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                      
  1               5                  10    


<210> 34
<211> 23
<212> PRT
<213> Homo sapiens

<400> 34
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys                                      
             20            


<210> 35
<211> 15
<212> PRT
<213> Homo sapiens

<400> 35
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr      
  1               5                  10                  15


<210> 36
<211> 32
<212> PRT
<213> Homo sapiens

<400> 36
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr  
  1               5                  10                  15    

Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys  
             20                  25                  30        

                                                                 



<210> 37
<211> 11
<212> PRT
<213> Homo sapiens

<400> 37
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg                      
  1               5                  10    


<210> 38
<211> 330
<212> PRT
<213> Homo sapiens

<400> 38
Ala Ser Thr Lys Gly Pro Ser Val Phe Phe Leu Ala Pro Ser Ser Lys  
  1               5                  10                  15    

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr  
             20                  25                  30        

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser  
         35                  40                  45            

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser  
     50                  55                  60                

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr  
 65                  70                  75                  80

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys  
                 85                  90                  95    

Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys  
            100                 105                 110        

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro  
        115                 120                 125            

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys  
    130                 135                 140                

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp  
145                 150                 155                 160

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu  
                165                 170                 175    

Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu  
            180                 185                 190        

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn  
        195                 200                 205            

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly  
    210                 215                 220                

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu  
225                 230                 235                 240

Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr  
                245                 250                 255    

Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn  
            260                 265                 270        

Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe  
        275                 280                 285            

Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn  
    290                 295                 300                

Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr  
305                 310                 315                 320

Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                          
                325                 330


<210> 39
<211> 330
<212> PRT
<213> Homo sapiens

<400> 39
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys  
  1               5                  10                  15    

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr  
             20                  25                  30        

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser  
         35                  40                  45            

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser  
     50                  55                  60                

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr  
 65                  70                  75                  80

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys  
                 85                  90                  95    

Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys  
            100                 105                 110        

Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro  
        115                 120                 125            

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys  
    130                 135                 140                

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp  
145                 150                 155                 160

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu  
                165                 170                 175    

Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu  
            180                 185                 190        

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn  
        195                 200                 205            

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly  
    210                 215                 220                

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu  
225                 230                 235                 240

Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr  
                245                 250                 255    

Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn  
            260                 265                 270        

Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe  
        275                 280                 285            

Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn  
    290                 295                 300                

Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr  
305                 310                 315                 320

Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                          
                325                 330


<210> 40
<211> 106
<212> PRT
<213> Homo sapiens

<400> 40
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln  
  1               5                  10                  15    

Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr  
             20                  25                  30        

Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser  
         35                  40                  45            

Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr  
     50                  55                  60                

Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys  
 65                  70                  75                  80

His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro  
                 85                  90                  95    

Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                          
            100                 105    


<210> 41
<211> 105
<212> PRT
<213> Homo sapiens

<400> 41
Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu  
  1               5                  10                  15    

Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe  
             20                  25                  30        

Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val  
         35                  40                  45            

Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys  
     50                  55                  60                

Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser  
 65                  70                  75                  80

His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu  
                 85                  90                  95    

Lys Thr Val Ala Pro Thr Glu Cys Ser                              
            100                 105


<210> 42
<211> 360
<212> DNA
<213> Homo sapiens

<400> 42
gaggtccagc tggtgcagtc tggagctgag gtgaagaagc ctggggcttc agtgaaggtg 60    
tcctgcaagg cttctggcta caccttcact accttctata tacactgggt gaggcaggcg 120   
cctggacagg gccttgagtg gattggaatg attggtcctg gaagtggtaa tacttactac 180   
aatgagatgt tcaaggacaa ggccacattg actgtagaca catccaccag cacagcctac 240   
atggagctca gcagcctcag atctgaggac actgcggtct attactgtgc aagagcaaag 300   
tcagctcggg cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctcttca 360   


<210> 43
<211> 339
<212> DNA
<213> Homo sapiens

<400> 43
gatattgtga tgacccaaag tccactctcc ctgcctgtca ctcctggaga accagcctcc 60    
atctcttgca gatctagtca gagcgttgta cagagtaatg gaaacaccta tttagaatgg 120   
tacctgcaga aaccaggcca gtctccacag ctcctgatct acaaagtttc caaccgattt 180   
tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc 240   
agcagagtgg aggctgagga tgtgggagtt tattactgct ttcaaggttc acatgttcct 300   
cccacgttcg gaggggggac caaggtggaa ataaaacgg                        339   


<210> 44
<211> 354
<212> DNA
<213> Homo sapiens

<400> 44
gaagtgaagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgagactc 60    
tcctgtgcag cctctggatt cactttcagt agctatgcca tgtcttgggt tcgccaggct 120   
ccagggaagg ggctagagtg ggtcgcgtcc attcataata gaggtactat cttctatcta 180   
gacagtgtga agggccgatt caccatctcc agagataatg tcaggaacac cctgtacctg 240   
caaatgaaca gtctgagggc tgaggacacg gccgtatatt actgtacaag aggccggagt 300   
aactcctatg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctcg       354   


<210> 45
<211> 339
<212> DNA
<213> Homo sapiens

<400> 45
gatgttttgg tgacccaatc tccactctcc ctgcctgtca cgcctggaga accagcctcc 60    
atctcttgcc gatctactca gacccttgta catcgtaatg gagacaccta tttagaatgg 120   
tacctgcaga aaccaggcca gtctccacag tccctgatct acaaagtttc caaccgattt 180   
tctggggtcc cagacaggtt cagcggcagt ggatcaggga cagatttcac actcaagatc 240   
agcagagtgg aggctgagga tgtgggagtt tattactgct ttcaaggttc acatgttccg 300   
tacacgttcg gacaggggac caagctggaa ataaaacgg                        339   


<210> 46
<211> 42
<212> PRT
<213> Homo sapiens

<400> 46
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys  
  1               5                  10                  15    

Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile  
             20                  25                  30        

Gly Leu Met Val Gly Gly Val Val Ile Ala                          
         35                  40        


<210> 47
<211> 40
<212> PRT
<213> Homo sapiens

<400> 47
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys  
  1               5                  10                  15    

Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile  
             20                  25                  30        

Gly Leu Met Val Gly Gly Val Val                                  
         35                  40


<210> 48
<211> 30
<212> PRT
<213> Homo sapiens

<400> 48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala  
  1               5                  10                  15    

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr          
             20                  25                  30


<210> 49
<211> 14
<212> PRT
<213> Homo sapiens

<400> 49
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly          
  1               5                  10                


<210> 50
<211> 32
<212> PRT
<213> Homo sapiens

<400> 50
Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu  
  1               5                  10                  15    

Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg  
             20                  25                  30        

                                                                 



<210> 51
<211> 11
<212> PRT
<213> Homo sapiens

<400> 51
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                      
  1               5                  10    


<210> 52
<211> 30
<212> PRT
<213> Homo sapiens

<400> 52
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly  
  1               5                  10                  15    

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser          
             20                  25                  30


<210> 53
<211> 14
<212> PRT
<213> Homo sapiens

<400> 53
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser          
  1               5                  10                


<210> 54
<211> 32
<212> PRT
<213> Homo sapiens

<400> 54
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln  
  1               5                  10                  15    

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg  
             20                  25                  30        

                                                                 



<210> 55
<211> 11
<212> PRT
<213> Homo sapiens

<400> 55
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                      
  1               5                  10    


<210> 56
<211> 23
<212> PRT
<213> Homo sapiens

<400> 56
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys                                      
             20            


<210> 57
<211> 15
<212> PRT
<213> Homo sapiens

<400> 57
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr      
  1               5                  10                  15


<210> 58
<211> 31
<212> PRT
<213> Homo sapiens

<400> 58
Gly Val Pro Asp Arg Phe Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu  
  1               5                  10                  15    

Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys      
             20                  25                  30    


<210> 59
<211> 11
<212> PRT
<213> Homo sapiens

<400> 59
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg                      
  1               5                  10    


<210> 60
<211> 23
<212> PRT
<213> Homo sapiens

<400> 60
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys                                      
             20            


<210> 61
<211> 15
<212> PRT
<213> Homo sapiens

<400> 61
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr      
  1               5                  10                  15


<210> 62
<211> 32
<212> PRT
<213> Homo sapiens

<400> 62
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr  
  1               5                  10                  15    

Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys  
             20                  25                  30        

                                                                 



<210> 63
<211> 11
<212> PRT
<213> Homo sapiens

<400> 63
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg                      
  1               5                  10    


<210> 64
<211> 43
<212> PRT
<213> Homo sapiens

<400> 64
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys  
  1               5                  10                  15    

Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile  
             20                  25                  30        

Gly Leu Met Val Gly Gly Val Val Ile Ala Thr                      
         35                  40            


<210> 65
<211> 9
<212> PRT
<213> Homo sapiens

<400> 65
Phe Gln Gly Ser His Val Pro Pro Thr                              
  1               5                


<210> 66
<211> 31
<212> PRT
<213> Homo sapiens

<400> 66
Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn  
  1               5                  10                  15    

Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala      
             20                  25                  30    


<210> 67
<211> 23
<212> PRT
<213> Homo sapiens

<400> 67
Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met  
  1               5                  10                  15    

Val Gly Gly Val Val Ile Ala                                      
             20            


<210> 68
<211> 120
<212> PRT
<213> Homo sapiens

<400> 68
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr  
  1               5                  10                  15    

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Phe  
             20                  25                  30        

Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile  
         35                  40                  45            

Gly Met Ile Gly Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Met Phe  
     50                  55                  60                

Lys Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr  
 65                  70                  75                  80

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys  
                 85                  90                  95    

Ala Arg Ala Lys Ser Ala Arg Ala Ala Trp Phe Ala Tyr Trp Gly Gln  
            100                 105                 110        

Gly Thr Leu Val Thr Val Ser Ala                                  
        115                 120


<210> 69
<211> 120
<212> PRT
<213> Homo sapiens

<400> 69
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala  
  1               5                  10                  15    

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Phe  
             20                  25                  30        

Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile  
         35                  40                  45            

Gly Met Ile Gly Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Met Phe  
     50                  55                  60                

Lys Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr  
 65                  70                  75                  80

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                 85                  90                  95    

Ala Arg Ala Lys Ser Ala Arg Ala Ala Trp Phe Ala Tyr Trp Gly Gln  
            100                 105                 110        

Gly Thr Leu Val Thr Val Ser Ser                                  
        115                 120


<210> 70
<211> 87
<212> PRT
<213> Homo sapiens

<400> 70
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala  
  1               5                  10                  15    

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Trp Val  
             20                  25                  30        

Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Val Thr Ile  
         35                  40                  45            

Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu  
     50                  55                  60                

Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly  
 65                  70                  75                  80

Thr Leu Val Thr Val Ser Ser                                      
                 85        


<210> 71
<211> 113
<212> PRT
<213> Homo sapiens

<400> 71
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly  
  1               5                  10                  15    

Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Val Val Gln Ser  
             20                  25                  30        

Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser  
         35                  40                  45            

Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro  
     50                  55                  60                

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile  
 65                  70                  75                  80

Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly  
                 85                  90                  95    

Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys  
            100                 105                 110        

Arg                                                              
   


<210> 72
<211> 113
<212> PRT
<213> Homo sapiens

<400> 72
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Val Val Gln Ser  
             20                  25                  30        

Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser  
         35                  40                  45            

Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro  
     50                  55                  60                

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile  
 65                  70                  75                  80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly  
                 85                  90                  95    

Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys  
            100                 105                 110        

Arg                                                              
   


<210> 73
<211> 81
<212> PRT
<213> Homo sapiens

<400> 73
Glu Leu Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys Trp Tyr Leu Gln Lys Pro Gly Gln Ser  
             20                  25                  30        

Pro Gln Leu Leu Ile Tyr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly  
         35                  40                  45            

Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp  
     50                  55                  60                

Val Gly Val Tyr Tyr Cys Phe Gly Gly Gly Thr Lys Val Glu Ile Lys  
 65                  70                  75                  80

Arg                                                              
   


