                               SEQUENCE LISTING                               

<110> Wyeth 

<120> METHODS AND COMPOSITIONS FOR MODULATING BMP-10 ACTIVITY 

<130> W2023-7015WO

<140>
<141>

<150> 60/932,815
<151> 2007-06-01

<160> 21                         

<170> PatentIn Ver. 3.3

<210> 1
<211> 1584
<212> DNA
<213> Homo sapiens

<400> 1
ggggagagga agagtggtag ggggagggag agagagagga agagtttcca aacttgtctc 60    
cagtgacagg agacatttac gttccacaag ataaaactgc cacttagagc ccagggaagc 120   
taaaccttcc tggcttggcc taggagctcg agcggagtca tgggctctct ggtcctgaca 180   
ctgtgcgctc ttttctgcct ggcagcttac ttggtttctg gcagccccat catgaaccta 240   
gagcagtctc ctctggaaga agatatgtcc ctctttggtg atgttttctc agagcaagac 300   
ggtgtcgact ttaacacact gctccagagc atgaaggatg agtttcttaa gacactaaac 360   
ctctctgaca tccccacgca ggattcagcc aaggtggacc caccagagta catgttggaa 420   
ctctacaaca aatttgcaac agatcggacc tccatgccct ctgccaacat cattaggagt 480   
ttcaagaatg aagatctgtt ttcccagccg gtcagtttta atgggctccg aaaatacccc 540   
ctcctcttca atgtgtccat tcctcaccat gaagaggtca tcatggctga acttaggcta 600   
tacacactgg tgcaaaggga tcgtatgata tacgatggag tagaccggaa aattaccatt 660   
tttgaagtgc tggagagcaa aggggataat gagggagaaa gaaacatgct ggtcttggtg 720   
tctggggaga tatatggaac caacagtgag tgggagactt ttgatgtcac agatgccatc 780   
agacgttggc aaaagtcagg ctcatccacc caccagctgg aggtccacat tgagagcaaa 840   
cacgatgaag ctgaggatgc cagcagtgga cggctagaaa tagataccag tgcccagaat 900   
aagcataacc ctttgctcat cgtgttttct gatgaccaaa gcagtgacaa ggagaggaag 960   
gaggaactga atgaaatgat ttcccatgag caacttccag agctggacaa cttgggcctg 1020  
gatagctttt ccagtggacc tggggaagag gctttgttgc agatgagatc aaacatcatc 1080  
tatgactcca ctgcccgaat cagaaggaac gccaaaggaa actactgtaa gaggaccccg 1140  
ctctacatcg acttcaagga gattgggtgg gactcctgga tcatcgctcc gcctggatac 1200  
gaagcctatg aatgccgtgg tgtttgtaac taccccctgg cagagcatct cacacccaca 1260  
aagcatgcaa ttatccaggc cttggtccac ctcaagaatt cccagaaagc ttccaaagcc 1320  
tgctgtgtgc ccacaaagct agagcccatc tccatcctct atttagacaa aggcgtcgtc 1380  
acctacaagt ttaaatacga aggcatggcc gtctccgaat gtggctgtag atagaagaag 1440  
agtcctatgg cttatttaat aactgtaaat gtgtatattt ggtgttccta tttaatgaga 1500  
ttatttaata agggtgtaca gtaatagagg cttgctgcct tcaggaaatg gacaggtcag 1560  
tttgttgtag gaaatgcata tttt                                        1584  


<210> 2
<211> 424
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Ser Leu Val Leu Thr Leu Cys Ala Leu Phe Cys Leu Ala Ala  
  1               5                  10                  15    

Tyr Leu Val Ser Gly Ser Pro Ile Met Asn Leu Glu Gln Ser Pro Leu  
             20                  25                  30        

Glu Glu Asp Met Ser Leu Phe Gly Asp Val Phe Ser Glu Gln Asp Gly  
         35                  40                  45            

Val Asp Phe Asn Thr Leu Leu Gln Ser Met Lys Asp Glu Phe Leu Lys  
     50                  55                  60                

Thr Leu Asn Leu Ser Asp Ile Pro Thr Gln Asp Ser Ala Lys Val Asp  
 65                  70                  75                  80

Pro Pro Glu Tyr Met Leu Glu Leu Tyr Asn Lys Phe Ala Thr Asp Arg  
                 85                  90                  95    

Thr Ser Met Pro Ser Ala Asn Ile Ile Arg Ser Phe Lys Asn Glu Asp  
            100                 105                 110        

Leu Phe Ser Gln Pro Val Ser Phe Asn Gly Leu Arg Lys Tyr Pro Leu  
        115                 120                 125            

Leu Phe Asn Val Ser Ile Pro His His Glu Glu Val Ile Met Ala Glu  
    130                 135                 140                

Leu Arg Leu Tyr Thr Leu Val Gln Arg Asp Arg Met Ile Tyr Asp Gly  
145                 150                 155                 160

Val Asp Arg Lys Ile Thr Ile Phe Glu Val Leu Glu Ser Lys Gly Asp  
                165                 170                 175    

Asn Glu Gly Glu Arg Asn Met Leu Val Leu Val Ser Gly Glu Ile Tyr  
            180                 185                 190        

Gly Thr Asn Ser Glu Trp Glu Thr Phe Asp Val Thr Asp Ala Ile Arg  
        195                 200                 205            

Arg Trp Gln Lys Ser Gly Ser Ser Thr His Gln Leu Glu Val His Ile  
    210                 215                 220                

Glu Ser Lys His Asp Glu Ala Glu Asp Ala Ser Ser Gly Arg Leu Glu  
225                 230                 235                 240

Ile Asp Thr Ser Ala Gln Asn Lys His Asn Pro Leu Leu Ile Val Phe  
                245                 250                 255    

Ser Asp Asp Gln Ser Ser Asp Lys Glu Arg Lys Glu Glu Leu Asn Glu  
            260                 265                 270        

Met Ile Ser His Glu Gln Leu Pro Glu Leu Asp Asn Leu Gly Leu Asp  
        275                 280                 285            

Ser Phe Ser Ser Gly Pro Gly Glu Glu Ala Leu Leu Gln Met Arg Ser  
    290                 295                 300                

Asn Ile Ile Tyr Asp Ser Thr Ala Arg Ile Arg Arg Asn Ala Lys Gly  
305                 310                 315                 320

Asn Tyr Cys Lys Arg Thr Pro Leu Tyr Ile Asp Phe Lys Glu Ile Gly  
                325                 330                 335    

Trp Asp Ser Trp Ile Ile Ala Pro Pro Gly Tyr Glu Ala Tyr Glu Cys  
            340                 345                 350        

Arg Gly Val Cys Asn Tyr Pro Leu Ala Glu His Leu Thr Pro Thr Lys  
        355                 360                 365            

His Ala Ile Ile Gln Ala Leu Val His Leu Lys Asn Ser Gln Lys Ala  
    370                 375                 380                

Ser Lys Ala Cys Cys Val Pro Thr Lys Leu Glu Pro Ile Ser Ile Leu  
385                 390                 395                 400

Tyr Leu Asp Lys Gly Val Val Thr Tyr Lys Phe Lys Tyr Glu Gly Met  
                405                 410                 415    

Ala Val Ser Glu Cys Gly Cys Arg                                  
            420                


<210> 3
<211> 4263
<212> DNA
<213> Homo sapiens

<400> 3
aggaaacggt ttattaggag ggagtggtgg agctgggcca ggcaggaaga cgctggaata 60    
agaaacattt ttgctccagc ccccatccca gtcccgggag gctgccgcgc cagctgcgcc 120   
gagcgagccc ctccccggct ccagcccggt ccggggccgc gcccggaccc cagcccgccg 180   
tccagcgctg gcggtgcaac tgcggccgcg cggtggaggg gaggtggccc cggtccgccg 240   
aaggctagcg ccccgccacc cgcagagcgg gcccagaggg accatgacct tgggctcccc 300   
caggaaaggc cttctgatgc tgctgatggc cttggtgacc cagggagacc ctgtgaagcc 360   
gtctcggggc ccgctggtga cctgcacgtg tgagagccca cattgcaagg ggcctacctg 420   
ccggggggcc tggtgcacag tagtgctggt gcgggaggag gggaggcacc cccaggaaca 480   
tcggggctgc gggaacttgc acagggagct ctgcaggggg cgccccaccg agttcgtcaa 540   
ccactactgc tgcgacagcc acctctgcaa ccacaacgtg tccctggtgc tggaggccac 600   
ccaacctcct tcggagcagc cgggaacaga tggccagctg gccctgatcc tgggccccgt 660   
gctggccttg ctggccctgg tggccctggg tgtcctgggc ctgtggcatg tccgacggag 720   
gcaggagaag cagcgtggcc tgcacagcga gctgggagag tccagtctca tcctgaaagc 780   
atctgagcag ggcgacagca tgttggggga cctcctggac agtgactgca ccacagggag 840   
tggctcaggg ctccccttcc tggtgcagag gacagtggca cggcaggttg ccttggtgga 900   
gtgtgtggga aaaggccgct atggcgaagt gtggcggggc ttgtggcacg gtgagagtgt 960   
ggccgtcaag atcttctcct cgagggatga acagtcctgg ttccgggaga ctgagatcta 1020  
taacacagtg ttgctcagac acgacaacat cctaggcttc atcgcctcag acatgacctc 1080  
ccgcaactcg agcacgcagc tgtggctcat cacgcactac cacgagcacg gctccctcta 1140  
cgactttctg cagagacaga cgctggagcc ccatctggct ctgaggctag ctgtgtccgc 1200  
ggcatgcggc ctggcgcacc tgcacgtgga gatcttcggt acacagggca aaccagccat 1260  
tgcccaccgc gacttcaaga gccgcaatgt gctggtcaag agcaacctgc agtgttgcat 1320  
cgccgacctg ggcctggctg tgatgcactc acagggcagc gattacctgg acatcggcaa 1380  
caacccgaga gtgggcacca agcggtacat ggcacccgag gtgctggacg agcagatccg 1440  
cacggactgc tttgagtcct acaagtggac tgacatctgg gcctttggcc tggtgctgtg 1500  
ggagattgcc cgccggacca tcgtgaatgg catcgtggag gactatagac cacccttcta 1560  
tgatgtggtg cccaatgacc ccagctttga ggacatgaag aaggtggtgt gtgtggatca 1620  
gcagaccccc accatcccta accggctggc tgcagacccg gtcctctcag gcctagctca 1680  
gatgatgcgg gagtgctggt acccaaaccc ctctgcccga ctcaccgcgc tgcggatcaa 1740  
gaagacacta caaaaaatta gcaacagtcc agagaagcct aaagtgattc aatagcccag 1800  
gagcacctga ttcctttctg cctgcagggg gctggggggg tggggggcag tggatggtgc 1860  
cctatctggg tagaggtagt gtgagtgtgg tgtgtgctgg ggatgggcag ctgcgcctgc 1920  
ctgctcggcc cccagcccac ccagccaaaa atacagctgg gctgaaacct gatcccctgc 1980  
tgtctggcct gctcaaagcg gcaggctccc tgacgcctgg ctctctcccc acccctatgg 2040  
ccagcatggt gcacccccta ccactcccgg gacaggatgc aaaagaggct ccagagtcag 2100  
agtgccaagc cagggaatcc cagtcccaga ctcagagccc gggcctgcac tttgccccct 2160  
gcccttgatc aaccccactg ccccaccaga gctgccaggg tggcacaggg ccctgtccag 2220  
cccctggcac acacttccct gccaggcctc agcctctagc ataagctcca gagagccagg 2280  
gcccatcagt ttctctctgt ggatttgtat ctcagctcca tgatgccttg ggctttctgt 2340  
ctcctcaaca agagtgcagc ttgctgaatg tcagctgcct gagagagctg gggcctgact 2400  
tactagggca ttaaatccta agaggtccta ctgaggtgtg gcaggatcac aggccagtgg 2460  
aaaaagggca ggtcagatgg gcaaggccca ggactttcag attaactgag aggatatcga 2520  
ggccaagcat ggcaggggga aggtcagtgg gtgtcaagag acccaggtct gaccccggat 2580  
gtttgctcca tgtgacaaaa gcaggcctgt ctcaggacct tttcttttct tttttccttc 2640  
tttttttttt tgacacggag tttcgctctt gttgtccagg ctagagtgca atggcatgat 2700  
cccagctcac cgcaacgtct acctcccagg ttcaaatcat tctcttgcct cagactcccg 2760  
agtagctggg attacaggca catgccacca tgcctggcta attttgtata tttagtagaa 2820  
acagggtttc accatgctgg ccatgctggt ctcgaactcc tgacctcagg tgttccacct 2880  
acctcagcct cccaaagtgc tggggttaca ggtgtgagcc atcgcgcctg gccaggacct 2940  
ttgtttctta tctacatatt ggaagatttg gtcctgatgt cctttgaggc ttctttagct 3000  
ctagttctct gacacttcag cctatatcac agctaacttc ttcagtctca tctattcctt 3060  
atgctccagc ccctggcaat ttgcctcaag atgggggttt gaaaataact ttacctgact 3120  
caaggagtgt ctggagcacc tcctagtcta agtctgcaag ctccagttct tgcctaaaac 3180  
catgccagtg gccacccttg ggctcagaca gctctgggcc ttttgaccac aagccagccc 3240  
ctcgccctct ctgtggcata gtcttctctg ccccaggact gcagggcggc ttcctccaag 3300  
gcttccaagg ctcaaaagaa atttggctcc atccaagaag gctccagctc ccctactggc 3360  
ccctggctca ggcccacacc cctggccagg cccagagagt gtgtctcagg agaattcaat 3420  
ggctctagag agacacacag aaagtttggc atttggaaat ttcaaggatg tatgtatgct 3480  
cacgtatgga gcaggttgtc ctggtccctg ggtgcaggga agtgggctgc agggaagtgg 3540  
attggagggg agcttgagga atataaggag cgggggtgga gactcaggct atggacaagg 3600  
acagccccaa ggttgggaag acctggcctt agtcgtcctc agcctagggg cagggcagtg 3660  
aagaaagctc tccccgctcc tgctgtaatg acccagagta gcctccccag gccggcatct 3720  
tatgtgtgtc ttccaccatc ctcatggtgg cacttttcta ggcctgtctc ccagcattgt 3780  
gcaaggctcg gaagagaacc aggaagtgaa actgggtgaa aacagaaagc tcaatggatg 3840  
ggctaggttc ccagatcatt agggcagagt ttgcacgtcc tctggtcact ggaatccacc 3900  
cagcccacga atcatctccc tcttgaagga ttttatttct actgggtttt ggaacaaact 3960  
cctgctgaga ccccacagcc agaaactgaa agcagcagct ccccaaagcc tggaaaatcc 4020  
ctaagagaag gcctggggca ggaagtggag tgacagggga caggtagaga gaagggggcc 4080  
caatggccag ggagtgaagg aggtggcgtt gctgagagca gtctgcacat gcttctgtct 4140  
gagtgcagga aggtgttcca gggtcgaaat tacacttctc gtacctggag acgctgtttg 4200  
tgggagcact gggctcatgc ctggcacaca ataggtctgc aataaaccat ggttaaatcc 4260  
tga                                                               4263  


<210> 4
<211> 503
<212> PRT
<213> Homo sapiens

<400> 4
Met Thr Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala  
  1               5                  10                  15    

Leu Val Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val  
             20                  25                  30        

Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr Cys Arg Gly  
         35                  40                  45            

Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly Arg His Pro Gln  
     50                  55                  60                

Glu His Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg  
 65                  70                  75                  80

Pro Thr Glu Phe Val Asn His Tyr Cys Cys Asp Ser His Leu Cys Asn  
                 85                  90                  95    

His Asn Val Ser Leu Val Leu Glu Ala Thr Gln Pro Pro Ser Glu Gln  
            100                 105                 110        

Pro Gly Thr Asp Gly Gln Leu Ala Leu Ile Leu Gly Pro Val Leu Ala  
        115                 120                 125            

Leu Leu Ala Leu Val Ala Leu Gly Val Leu Gly Leu Trp His Val Arg  
    130                 135                 140                

Arg Arg Gln Glu Lys Gln Arg Gly Leu His Ser Glu Leu Gly Glu Ser  
145                 150                 155                 160

Ser Leu Ile Leu Lys Ala Ser Glu Gln Gly Asp Ser Met Leu Gly Asp  
                165                 170                 175    

Leu Leu Asp Ser Asp Cys Thr Thr Gly Ser Gly Ser Gly Leu Pro Phe  
            180                 185                 190        

Leu Val Gln Arg Thr Val Ala Arg Gln Val Ala Leu Val Glu Cys Val  
        195                 200                 205            

Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg Gly Leu Trp His Gly Glu  
    210                 215                 220                

Ser Val Ala Val Lys Ile Phe Ser Ser Arg Asp Glu Gln Ser Trp Phe  
225                 230                 235                 240

Arg Glu Thr Glu Ile Tyr Asn Thr Val Leu Leu Arg His Asp Asn Ile  
                245                 250                 255    

Leu Gly Phe Ile Ala Ser Asp Met Thr Ser Arg Asn Ser Ser Thr Gln  
            260                 265                 270        

Leu Trp Leu Ile Thr His Tyr His Glu His Gly Ser Leu Tyr Asp Phe  
        275                 280                 285            

Leu Gln Arg Gln Thr Leu Glu Pro His Leu Ala Leu Arg Leu Ala Val  
    290                 295                 300                

Ser Ala Ala Cys Gly Leu Ala His Leu His Val Glu Ile Phe Gly Thr  
305                 310                 315                 320

Gln Gly Lys Pro Ala Ile Ala His Arg Asp Phe Lys Ser Arg Asn Val  
                325                 330                 335    

Leu Val Lys Ser Asn Leu Gln Cys Cys Ile Ala Asp Leu Gly Leu Ala  
            340                 345                 350        

Val Met His Ser Gln Gly Ser Asp Tyr Leu Asp Ile Gly Asn Asn Pro  
        355                 360                 365            

Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Gln  
    370                 375                 380                

Ile Arg Thr Asp Cys Phe Glu Ser Tyr Lys Trp Thr Asp Ile Trp Ala  
385                 390                 395                 400

Phe Gly Leu Val Leu Trp Glu Ile Ala Arg Arg Thr Ile Val Asn Gly  
                405                 410                 415    

Ile Val Glu Asp Tyr Arg Pro Pro Phe Tyr Asp Val Val Pro Asn Asp  
            420                 425                 430        

Pro Ser Phe Glu Asp Met Lys Lys Val Val Cys Val Asp Gln Gln Thr  
        435                 440                 445            

Pro Thr Ile Pro Asn Arg Leu Ala Ala Asp Pro Val Leu Ser Gly Leu  
    450                 455                 460                

Ala Gln Met Met Arg Glu Cys Trp Tyr Pro Asn Pro Ser Ala Arg Leu  
465                 470                 475                 480

Thr Ala Leu Arg Ile Lys Lys Thr Leu Gln Lys Ile Ser Asn Ser Pro  
                485                 490                 495    

Glu Lys Pro Lys Val Ile Gln                                      
            500            


<210> 5
<211> 3631
<212> DNA
<213> Homo sapiens

<400> 5
gcggccgctg cagagattgg aatccgcctg ccgggcttgg cgaaggagaa gggaggaggc 60    
aggagcgagg agggaggagg gccaagggcg ggcaggaagg cttaggctcg gcgcgtccgt 120   
ccgcgcgcgg cgaagatcgc acggcccgat cgaggggcga ccgggtcggg gccgctgcac 180   
gccaagggcg aaggccgatt cgggccccac ttcgccccgg cggctcgccg cgcccacccg 240   
ctccgcgccg agggctggag gatgcgttcc ctggggtccg gacttatgaa aatatgcatc 300   
agtttaatac tgtcttggaa ttcatgagat ggaagcatag gtcaaagctg tttggagaaa 360   
atcagaagta cagttttatc tagccacatc ttggaggagt cgtaagaaag cagtgggagt 420   
tgaagtcatt gtcaagtgct tgcgatcttt tacaagaaaa tctcactgaa tgatagtcat 480   
ttaaattggt gaagtagcaa gaccaattat taaaggtgac agtacacagg aaacattaca 540   
attgaacaat gcctcagcta tacatttaca tcagattatt gggagcctat ttgttcatca 600   
tttctcgtgt tcaaggacag aatctggata gtatgcttca tggcactggg atgaaatcag 660   
actccgacca gaaaaagtca gaaaatggag taaccttagc accagaggat accttgcctt 720   
ttttaaagtg ctattgctca gggcactgtc cagatgatgc tattaataac acatgcataa 780   
ctaatggaca ttgctttgcc atcatagaag aagatgacca gggagaaacc acattagctt 840   
cagggtgtat gaaatatgaa ggatctgatt ttcagtgcaa agattctcca aaagcccagc 900   
tacgccggac aatagaatgt tgtcggacca atttatgtaa ccagtatttg caacccacac 960   
tgccccctgt tgtcataggt ccgttttttg atggcagcat tcgatggctg gttttgctca 1020  
tttctatggc tgtctgcata attgctatga tcatcttctc cagctgcttt tgttacaaac 1080  
attattgcaa gagcatctca agcagacgtc gttacaatcg tgatttggaa caggatgaag 1140  
catttattcc agttggagaa tcactaaaag accttattga ccagtcacaa agttctggta 1200  
gtgggtctgg actaccttta ttggttcagc gaactattgc caaacagatt cagatggtcc 1260  
ggcaagttgg taaaggccga tatggagaag tatggatggg caaatggcgt ggcgaaaaag 1320  
tggcggtgaa agtattcttt accactgaag aagccagctg gtttcgagaa acagaaatct 1380  
accaaactgt gctaatgcgc catgaaaaca tacttggttt catagcggca gacattaaag 1440  
gtacaggttc ctggactcag ctctatttga ttactgatta ccatgaaaat ggatctctct 1500  
atgacttcct gaaatgtgct acactggaca ccagagccct gcttaaattg gcttattcag 1560  
ctgcctgtgg tctgtgccac ctgcacacag aaatttatgg cacccaagga aagcccgcaa 1620  
ttgctcatcg agacctaaag agcaaaaaca tcctcatcaa gaaaaatggg agttgctgca 1680  
ttgctgacct gggccttgct gttaaattca acagtgacac aaatgaagtt gatgtgccct 1740  
tgaataccag ggtgggcacc aaacgctaca tggctcccga agtgctggac gaaagcctga 1800  
acaaaaacca cttccagccc tacatcatgg ctgacatcta cagcttcggc ctaatcattt 1860  
gggagatggc tcgtcgttgt atcacaggag ggatcgtgga agaataccaa ttgccatatt 1920  
acaacatggt accgagtgat ccgtcatacg aagatatgcg tgaggttgtg tgtgtcaaac 1980  
gtttgcggcc aattgtgtct aatcggtgga acagtgatga atgtctacga gcagttttga 2040  
agctaatgtc agaatgctgg gcccacaatc cagcctccag actcacagca ttgagaatta 2100  
agaagacgct tgccaagatg gttgaatccc aagatgtaaa aatctgatgg ttaaaccatc 2160  
ggaggagaaa ctctagactg caagaactgt ttttacccat ggcatgggtg gaattagagt 2220  
ggaataagga tgttaacttg gttctcagac tctttcttca ctacgtgttc acaggctgct 2280  
aatattaaac ctttcagtac tcttattagg atacaagctg ggaacttcta aacacttcat 2340  
tctttatata tggacagctt tattttaaat gtggtttttg atgccttttt ttaagtgggt 2400  
ttttatgaac tgcatcaaga cttcaatcct gattagtgtc tccagtcaag ctctgggtac 2460  
tgaattgcct gttcataaaa cggtgctttc tgtgaaagcc ttaagaagat aaatgagcgc 2520  
agcagagatg gagaaataga ctttgccttt tacctgagac attcagttcg tttgtattct 2580  
acctttgtaa aacagcctat agatgatgat gtgtttggga tactgcttat tttatgatag 2640  
tttgtcctgt gtccttagtg atgtgtgtgt gtctccatgc acatgcacgc cgggattcct 2700  
ctgctgccat ttgaattaga agaaaataat ttatatgcat gcacaggaag atattggtgg 2760  
ccggtggttt tgtgctttaa aaatgcaata tctgaccaag attcgccaat ctcatacaag 2820  
ccatttactt tgcaagtgag atagcttccc caccagcttt attttttaac atgaaagctg 2880  
atgccaaggc caaaagaagt ttaaagcatc tgtaaatttg gactgttttc cttcaaccac 2940  
catttttttt gtggttatta tttttgtcac ggaaagcatc ctctccaaag ttggagcttc 3000  
tattgccatg aaccatgctt acaaagaaag cacttcttat tgaagtgaat tcctgcattt 3060  
gatagcaatg taagtgccta taaccatgtt ctatattctt tattctcagt aacttttaaa 3120  
agggaagtta tttatatttt gtgtataatg tgctttattt gcaaatcacc cactccttta 3180  
caaccatact ttatatatgt acatacattc atactgtaga aaccagctca tgtgtacctc 3240  
atatcccatc cttaagagaa gaaatgttat aaagtagaac taaatataaa ttttcagaat 3300  
taatgcattc aaagtaatat atcaaatcca ggactttgtt aacttcaggt aaaaacttca 3360  
ttagggtaat atcatctcaa ttttttcaaa tgaaaggatt ctctaattag aaatttatat 3420  
gtcagagctg ttataaattt atcaactgtc aaatatgttc tggacagcta aatcatttga 3480  
gatttttggt tttttgattt ctattcccta acttgtgaag acaatgaaaa atcaggcaga 3540  
aatatttagt atctagtcag tatctgtagc tacactgtat aactgttctt caataaaatg 3600  
gttcatattt tatagaaaaa aaaaaaaaaa a                                3631  


<210> 6
<211> 532
<212> PRT
<213> Homo sapiens

<400> 6
Met Pro Gln Leu Tyr Ile Tyr Ile Arg Leu Leu Gly Ala Tyr Leu Phe  
  1               5                  10                  15    

Ile Ile Ser Arg Val Gln Gly Gln Asn Leu Asp Ser Met Leu His Gly  
             20                  25                  30        

Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu Asn Gly Val  
         35                  40                  45            

Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys Tyr Cys Ser  
     50                  55                  60                

Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn Gly  
 65                  70                  75                  80

His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr Leu  
                 85                  90                  95    

Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys Asp  
            100                 105                 110        

Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr Asn  
        115                 120                 125            

Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val Val Ile Gly  
    130                 135                 140                

Pro Phe Phe Asp Gly Ser Ile Arg Trp Leu Val Leu Leu Ile Ser Met  
145                 150                 155                 160

Ala Val Cys Ile Ile Ala Met Ile Ile Phe Ser Ser Cys Phe Cys Tyr  
                165                 170                 175    

Lys His Tyr Cys Lys Ser Ile Ser Ser Arg Arg Arg Tyr Asn Arg Asp  
            180                 185                 190        

Leu Glu Gln Asp Glu Ala Phe Ile Pro Val Gly Glu Ser Leu Lys Asp  
        195                 200                 205            

Leu Ile Asp Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu Pro Leu  
    210                 215                 220                

Leu Val Gln Arg Thr Ile Ala Lys Gln Ile Gln Met Val Arg Gln Val  
225                 230                 235                 240

Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu  
                245                 250                 255    

Lys Val Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser Trp Phe  
            260                 265                 270        

Arg Glu Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu Asn Ile  
        275                 280                 285            

Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp Thr Gln  
    290                 295                 300                

Leu Tyr Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Phe  
305                 310                 315                 320

Leu Lys Cys Ala Thr Leu Asp Thr Arg Ala Leu Leu Lys Leu Ala Tyr  
                325                 330                 335    

Ser Ala Ala Cys Gly Leu Cys His Leu His Thr Glu Ile Tyr Gly Thr  
            340                 345                 350        

Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile  
        355                 360                 365            

Leu Ile Lys Lys Asn Gly Ser Cys Cys Ile Ala Asp Leu Gly Leu Ala  
    370                 375                 380                

Val Lys Phe Asn Ser Asp Thr Asn Glu Val Asp Val Pro Leu Asn Thr  
385                 390                 395                 400

Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Ser  
                405                 410                 415    

Leu Asn Lys Asn His Phe Gln Pro Tyr Ile Met Ala Asp Ile Tyr Ser  
            420                 425                 430        

Phe Gly Leu Ile Ile Trp Glu Met Ala Arg Arg Cys Ile Thr Gly Gly  
        435                 440                 445            

Ile Val Glu Glu Tyr Gln Leu Pro Tyr Tyr Asn Met Val Pro Ser Asp  
    450                 455                 460                

Pro Ser Tyr Glu Asp Met Arg Glu Val Val Cys Val Lys Arg Leu Arg  
465                 470                 475                 480

Pro Ile Val Ser Asn Arg Trp Asn Ser Asp Glu Cys Leu Arg Ala Val  
                485                 490                 495    

Leu Lys Leu Met Ser Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu  
            500                 505                 510        

Thr Ala Leu Arg Ile Lys Lys Thr Leu Ala Lys Met Val Glu Ser Gln  
        515                 520                 525            

Asp Val Lys Ile                                                  
    530        


<210> 7
<211> 20
<212> DNA
<213> Homo sapiens

<400> 7
gccactggat ctgtccgatt                                             20    


<210> 8
<211> 19
<212> DNA
<213> Homo sapiens

<400> 8
cacccggagc agtgatgag                                              19    


<210> 9
<211> 34
<212> DNA
<213> Homo sapiens

<400> 9
acattgtctt acactgaaac ggaggctacc aact                             34    


<210> 10
<211> 20
<212> DNA
<213> Homo sapiens

<400> 10
cagaaggtgc ggagcaaaat                                             20    


<210> 11
<211> 21
<212> DNA
<213> Homo sapiens

<400> 11
tgtacaccca cacaccatcc a                                           21    


<210> 12
<211> 20
<212> DNA
<213> Homo sapiens

<400> 12
ctgcggcatc cagctgacgc                                             20    


<210> 13
<211> 20
<212> DNA
<213> Homo sapiens

<400> 13
ccacatcgct cagacaccat                                             20    


<210> 14
<211> 18
<212> DNA
<213> Homo sapiens

<400> 14
gcgcccaata cgaccaaa                                               18    


<210> 15
<211> 25
<212> DNA
<213> Homo sapiens

<400> 15
cgttgactcc gaccttcacc ttccc                                       25    


<210> 16
<211> 2912
<212> DNA
<213> Homo sapiens

<400> 16
tgaggagaac aaaaaagaga gagagagccg agcgggggag cgatcgaggg agctgagccg 60    
agagaaagag ccgccgggcg ctgcctcgcc agacctcgct gggaccccgg ggccaccggg 120   
aggcactttt gtggaggggg gagggggggc gacctcggca gcctcggcgc acgaagcgtc 180   
cgagggcagc gtggggcggg ctgcgacctc tgcatcggtg gactgcattt ttaattaagg 240   
attcccagca gctctttggg atttttacag cttccactca tgtgttgaca cccgcgtcca 300   
ggagaaactc gctccaagtg catctagcgc ctgggacctg agacggcgtt ggcctttcgt 360   
gcatgcaaat ccagggattt aggttttgtt tgggatttcc ttttctttct ttcctttttt 420   
ttttcttttt gcagggagta agaagggagc tgggggtatc aacaagcctg cctttcggat 480   
cctgcgggaa aagcccatgt agttaagcgc tttggtttaa aaaaaaggca aggtaaaggc 540   
agggctttcc agacacattt aggggttcgc gcgagcgctt tgtgctcatg gaccagccgc 600   
acaacttttg aaggctcgcc ggcccatgtg gggtctttct ggcggcgcgc cgcctgcagc 660   
ccccctaaag cgcgggggct ggagttgttg agcagccccg ccgctgtggt ccatgtagcc 720   
gctggccgcg cgcggactgc ggctcggcgt gcgcgtgttc ccggccgtcc cgcctcggcg 780   
agctccctca tgttgtcgcc ctgcggcgcc ccttcgacga caggctgtgc gcggtctgca 840   
cggcgctccg cggcggagct tcatgtgggg ctgcgacccg cgcagccggc gcctcgctga 900   
gggaacggac ccccggtaac cggagaccgc ctccccccca cccctggcgc caaaggatat 960   
cgtatgttca ggtccaaacg ctcggggctg gtgcggcgac tttggcgaag tcgtgtggtc 1020  
cccgaccggg aggaaggcgg cagcggcggc ggcggtggcg gcgacgagga tgggagcttg 1080  
ggcagccgag ctgagccggc cccgcgggca agagagggcg gaggctgcgg ccgctccgaa 1140  
gtccgcccgg tagccccgcg gcggccccgg gacgcagtgg gacagcgagg cgcccagggc 1200  
gcggggaggc gccggcgcgc agggggcccc ccgaggccca tgtcggagcc aggggccggc 1260  
gctgggagct ccctgctgga cgtggcggag ccgggaggcc cgggctggct gcccgagagt 1320  
gactgcgaga cggtgacctg ctgtctcttt tcggagcggg acgccgccgg cgcgccccgg 1380  
gacgccagcg accccctggc cggggcggcc ctggagccgg cgggcggcgg gcggagtcgc 1440  
gaagcgcgct cgcggctgct gctgctggag caggaactca aaaccgtcac gtactcgctg 1500  
ctgaagcggc tcaaggagcg ctcgctggac acgctgctgg aggcggtgga gtcccgcggc 1560  
ggcgtgccgg gcggctgcgt gctggtgccg cgcgccgacc tccgcctggg cggccagccc 1620  
gcgccgccgc agctgctgct cggccgcctc tttcgctggc ccgacctgca gcacgccgtg 1680  
gagctgaagc ccctgtgcgg ctgccacagc ttcgccgccg ccgccgacgg ccctaccgtg 1740  
tgctgcaacc cctaccactt cagccggctc tgcgggcccg aatctccgcc acctccctac 1800  
tctcggctgt ctcctcgcga cgagtacaag ccactggatc tgtccgattc cacattgtct 1860  
tacactgaaa cggaggctac caactccctc atcactgctc cgggtgaatt ctcagacgcc 1920  
agcatgtctc cggacgccac caagccgagc cactggtgca gcgtggcgta ctgggagcac 1980  
cggacgcgcg tgggccgcct ctatgcggtg tacgaccagg ccgtcagcat cttctacgac 2040  
ctacctcagg gcagcggctt ctgcctgggc cagctcaacc tggagcagcg cagcgagtcg 2100  
gtgcggcgaa cgcgcagcaa gatcggcttc ggcatcctgc tcagcaagga gcccgacggc 2160  
gtgtgggcct acaaccgcgg cgagcacccc atcttcgtca actccccgac gctggacgcg 2220  
cccggcggcc gcgccctggt cgtgcgcaag gtgccccccg gctactccat caaggtgttc 2280  
gacttcgagc gctcgggcct gcagcacgcg cccgagcccg acgccgccga cggcccctac 2340  
gaccccaaca gcgtccgcat cagcttcgcc aagggctggg ggccctgcta ctcccggcag 2400  
ttcatcacct cctgcccctg ctggctggag atcctcctca acaaccccag atagtggcgg 2460  
ccccggcggg aggggcgggt gggaggccgc ggccaccgcc acctgccggc ctcgagaggg 2520  
gccgatgccc agagacacag cccccacgga caaaaccccc cagatatcat ctacctagat 2580  
ttaatataaa gttttatata ttatatggaa atatatatta tacttgtaat tatggagtca 2640  
tttttacaat gtaattattt atgtatggtg caatgtgtgt atatggacaa aacaagaaag 2700  
acgcactttg gcttataatt ctttcaatac agatatattt tctttctctt cctccttcct 2760  
cttccttact ttttatatat atatataaag aaaatgatac agcagagcta ggtggaaaag 2820  
cctgggtttg gtgtatggtt tttgagatat taatgcccag acaaaaagct aataccagtc 2880  
actcgataat aaagtattcg cattataaaa aa                               2912  


<210> 17
<211> 1080
<212> DNA
<213> Homo sapiens

<400> 17
atgcctctcc tcctcttgct gctcctgctg ccaagcccct tacacgcggg cagcggcaga 60    
ggcgaggccg agaccagaga gtgcatctac tacaacgcca actgggagct ggagaggacc 120   
aaccagagcg gcctggagag atgcgagggc gagcaggaca agaggctgca ctgctacgcc 180   
agctggcgca acagcagcgg caccatcgag ctggtgaaga agggctgctg gctggacgac 240   
ttcaactgct acgacaggca ggagtgcgtc gccaccgagg agaaccccca ggtgtacttc 300   
tgctgctgcg agggcaactt ctgcaacgag aggttcaccc acctgcccga ggctggcggc 360   
cctgaggtga cctacgagcc ccctcccacc gcccccaccg acaaaactca cacatgccca 420   
ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc 480   
aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 540   
cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc 600   
aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc 660   
gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc 720   
ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag 780   
gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc 840   
ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg 900   
gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctat 960   
agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg 1020  
atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc cccgggtaaa 1080  


<210> 18
<211> 360
<212> PRT
<213> Homo sapiens

<400> 18
Met Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Ser Pro Leu His Ala  
  1               5                  10                  15    

Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr Asn  
             20                  25                  30        

Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg Cys  
         35                  40                  45            

Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn  
     50                  55                  60                

Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp  
 65                  70                  75                  80

Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro  
                 85                  90                  95    

Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe  
            100                 105                 110        

Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro  
        115                 120                 125            

Pro Thr Ala Pro Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala  
    130                 135                 140                

Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro  
145                 150                 155                 160

Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val  
                165                 170                 175    

Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val  
            180                 185                 190        

Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln  
        195                 200                 205            

Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln  
    210                 215                 220                

Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala  
225                 230                 235                 240

Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro  
                245                 250                 255    

Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr  
            260                 265                 270        

Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser  
        275                 280                 285            

Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr  
    290                 295                 300                

Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr  
305                 310                 315                 320

Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe  
                325                 330                 335    

Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys  
            340                 345                 350        

Ser Leu Ser Leu Ser Pro Gly Lys                                  
        355                 360


<210> 19
<211> 40
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      Peptide

<220> 
<221> REPEAT
<222> (1)..(40)
<223> This peptide may encompass 1-8 Ser-Gly-Gly-Gly-Gly 
      repeats, thus, residues 6-40 may or may not be 
      present

<400> 19
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser  
  1               5                  10                  15    

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly  
             20                  25                  30        

Gly Gly Gly Ser Gly Gly Gly Gly                                  
         35                  40


<210> 20
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic 
      six-his peptide

<400> 20
His His His His His His                                          
  1               5    


<210> 21
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      Peptide

<400> 21
Asp Lys Gly Val Val Thr Tyr Lys Phe Lys Tyr Glu                  
  1               5                  10        


