                         SEQUENCE LISTING



<110>  Dow Chemical

      Retallack, Diane  M

      Mitchell, Jon C



<120>  Expression of Soluble Antibody Fragment by Truncation of CH1 Domain



<130>  2971.01-8345US



<160>  22    



<170>  PatentIn version 3.1



<210>  1

<211>  41

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Chemically synthesized: primer gal2HC_5' 

<400>  1
actagtagga ggtaacttat gaaactgaaa cgtttgatgg c                         41


<210>  2

<211>  39

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Chemically synthesized: primer XbaI_VhCH1_R

<400>  2
tctagatcat tactaaacgc gcttgtcacc tttcgtgtt                            39


<210>  3

<211>  39

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Chemically synthesized: primer XbaI_pbp_F 

<400>  3
tctagaagga ggtaacttat gaaactgaaa cgtttgatg                            39


<210>  4

<211>  39

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Chemically synthesized: primer XhoI_L_R 

<400>  4
ctcgagctat cattagcact cgccgcgatt aaacgactt                            39


<210>  5

<211>  46

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Chemically synthesized: primer gal2HC_5'

<400>  5
actagtagga ggtaacttat gaaactgaaa cgtttgatgg cggcaa                    46


<210>  6

<211>  35

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Chemically synthesized: primer CH1_rev 

<400>  6
cgtctagatt atcactagca cgatttcggc tcaac                                35


<210>  7

<211>  36

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Chemically synthesized: primer CH1_hinge

<400>  7
gctctagatt actatcagca cggcgggcag gtatgc                               36


<210>  8

<211>  97

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Chemically synthesized: plasmid gal2 FAB HC-JM(146)

<400>  8

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
1               5                   10                  15      


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            20                  25                  30          


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        35                  40                  45              


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
65                  70                  75                  80  


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
                85                  90                  95      


Val 
    


<210>  9

<211>  102

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Chemically synthesized: plasmid gal2 Fab1 Hc YS (122)

<400>  9

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
1               5                   10                  15      


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            20                  25                  30          


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        35                  40                  45              


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
65                  70                  75                  80  


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
                85                  90                  95      


Val Glu Pro Lys Ser Cys 
            100         


<210>  10

<211>  111

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Chemically synthesized: plasmid gal2 Fab2 YS (122)

<400>  10

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
1               5                   10                  15      


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            20                  25                  30          


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        35                  40                  45              


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
65                  70                  75                  80  


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
                85                  90                  95      


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110     


<210>  11

<211>  102

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  consensus sequence

<400>  11

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
1               5                   10                  15      


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            20                  25                  30          


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        35                  40                  45              


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
65                  70                  75                  80  


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
                85                  90                  95      


Val Glu Pro Lys Ser Cys 
            100         


<210>  12

<211>  12

<212>  DNA

<213>  Artificial



<220>

<223>  pbp heavy chain



<400>  12
aggaggtaac tt                                                         12


<210>  13

<211>  12

<212>  DNA

<213>  Artificial



<220>

<223>  pbp light chain



<400>  13
aggaggtaac tt                                                         12


<210>  14

<211>  1620

<212>  DNA

<213>  Artificial



<220>

<221>  CDS

<222>  (119)..(844)

<223>  Coding Region of pDOW1196



<220>

<221>  CDS

<222>  (872)..(1585)

<223>  Coding Region of pDOW1196



<400>  14
tttattctga aatgagctgt tgacaattaa tcatcggctc gtataatgtg tggaattgtg     60

agcggataac aatttcacac aggaaacaga attttaatct actagtagga ggtaactt      118

atg aaa ctg aaa cgt ttg atg gcg gca atg act ttt gtc gct gct ggc      166
Met Lys Leu Lys Arg Leu Met Ala Ala Met Thr Phe Val Ala Ala Gly         
1               5                   10                  15              

gtt gcg acc gcc aac gcg gtg gcc cag gtg cag ctg cag gag tcg ggc      214
Val Ala Thr Ala Asn Ala Val Ala Gln Val Gln Leu Gln Glu Ser Gly         
            20                  25                  30                  

cca gga ctg gtg aag cct tcg gag acc ctg tcc ctc acc tgc act gtc      262
Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val         
        35                  40                  45                      

tct ggt ggt tcc atc agt agt tat cac tgg agc tgg atc cgg cag ccc      310
Ser Gly Gly Ser Ile Ser Ser Tyr His Trp Ser Trp Ile Arg Gln Pro         
    50                  55                  60                          

cca ggg aag gga ctg gag tgg att ggg tat atc tat tac agt ggg agc      358
Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser         
65                  70                  75                  80          

acc aac tac aac ccc tcc ctc aag aat cga gtc acc ata tct gta gac      406
Thr Asn Tyr Asn Pro Ser Leu Lys Asn Arg Val Thr Ile Ser Val Asp         
                85                  90                  95              

acg tcc aag aac cag ttc tcc ctg aac ctg agg tct gtg acc gct gca      454
Thr Ser Lys Asn Gln Phe Ser Leu Asn Leu Arg Ser Val Thr Ala Ala         
            100                 105                 110                 

gac acg gcc gtg tat tac tgt gcg cga gga acg tat ggc cca gcc gga      502
Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Gly Pro Ala Gly         
        115                 120                 125                     

gat gct ttt gat atc tgg ggg caa ggg acc acg gtc acc gtc tcg tcg      550
Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser         
    130                 135                 140                         

gcc tcc acg aaa ggc ccg agc gtg ttc ccg ctg gcg cca agc tcc aag      598
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys         
145                 150                 155                 160         

agc acc agc ggc ggc acc gcc gcg ctg ggt tgt ctc gtc aaa gat tac      646
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr         
                165                 170                 175             

ttc ccc gaa ccg gtg acc gtg tcg tgg aac tcc ggg gcg ctg acc agc      694
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser         
            180                 185                 190                 

ggt gtc cat acc ttc cct gcc gtg ctc cag tcc tcc ggc ctg tat tcc      742
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser         
        195                 200                 205                     

ctg agc tcg gtg gtg acc gtg ccg tcg tcg agc ttg ggc acc caa acc      790
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr         
    210                 215                 220                         

tac atc tgc aac gtc aac cat aag ccc tcc aac acg aaa gtt gac aag      838
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys         
225                 230                 235                 240         

cgc gtt tagtaatgat ctagaaggag gtaactt atg aaa ctg aaa cgt ttg atg    892
Arg Val                               Met Lys Leu Lys Arg Leu Met       
                                              245                       

gcg gca atg act ttt gtc gct gct ggc gtt gcg acc gcc aac gcg gtg      940
Ala Ala Met Thr Phe Val Ala Ala Gly Val Ala Thr Ala Asn Ala Val         
250                 255                 260                 265         

gcc gac atc cag atg acc cag tct cct tcc acc ctg tct gca tct att      988
Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile         
                270                 275                 280             

gga gac aga gtc acc atc acc tgc cgg gcc agt gag ggt att tat cac     1036
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His         
            285                 290                 295                 

tgg ttg gcc tgg tat cag cag aag cca ggg aaa gcc cct aaa ctc ctg     1084
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu         
        300                 305                 310                     

atc tat aag gcc tct agt tta gcc agt ggg gcc cca tca agg ttc agc     1132
Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser         
    315                 320                 325                         

ggc agt gga tct ggg aca gat ttc act ctc acc atc agc agc ctg cag     1180
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln         
330                 335                 340                 345         

cct gat gat ttt gca act tat tac tgc caa caa tat agt aat tat ccg     1228
Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro         
                350                 355                 360             

ctc act ttc ggc gga ggg acc aag ctg gag atc aaa cgt gcg gtc gcc     1276
Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Val Ala         
            365                 370                 375                 

gcc ccg tcg gtt ttc att ttc ccg cca tcg gat gag cag ctc aag tcg     1324
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser         
        380                 385                 390                     

ggc acg gcg agc gtg gtc tgc ctg ctc aac aac ttt tac ccg cgc gag     1372
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu         
    395                 400                 405                         

gcc aag gtg cag tgg aag gtc gac aac gcc ctg cag tcg ggc aac agc     1420
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser         
410                 415                 420                 425         

cag gag tcg gtc acc gag cag gat agc aag gat tcc acc tat tcc ctc     1468
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu         
                430                 435                 440             

agc tcg acc ctg acg ctg agc aag gcc gat tat gag aag cat aaa gtt     1516
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val         
            445                 450                 455                 

tac gct tgt gaa gtg acc cac cag ggc ctg agc agc ccg gtg acc aag     1564
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys         
        460                 465                 470                     

tcg ttt aat cgc ggc gag tgc taatgatagc tcgagcccaa aacgaaaggc        1615
Ser Phe Asn Arg Gly Glu Cys                                             
    475                 480                                             

tcagt                                                               1620


<210>  15

<211>  480

<212>  PRT

<213>  Artificial

<220>

<223> Amino Acid sequence corresponding to Coding Region of pDOW1196



<400>  15

Met Lys Leu Lys Arg Leu Met Ala Ala Met Thr Phe Val Ala Ala Gly 
1               5                   10                  15      


Val Ala Thr Ala Asn Ala Val Ala Gln Val Gln Leu Gln Glu Ser Gly 
            20                  25                  30          


Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val 
        35                  40                  45              


Ser Gly Gly Ser Ile Ser Ser Tyr His Trp Ser Trp Ile Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser 
65                  70                  75                  80  


Thr Asn Tyr Asn Pro Ser Leu Lys Asn Arg Val Thr Ile Ser Val Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Ser Leu Asn Leu Arg Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Gly Pro Ala Gly 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Arg Val Met Lys Leu Lys Arg Leu Met Ala Ala Met Thr Phe Val Ala 
                245                 250                 255     


Ala Gly Val Ala Thr Ala Asn Ala Val Ala Asp Ile Gln Met Thr Gln 
            260                 265                 270         


Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr 
        275                 280                 285             


Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu 
305                 310                 315                 320 


Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                325                 330                 335     


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr 
        355                 360                 365             


Lys Leu Glu Ile Lys Arg Ala Val Ala Ala Pro Ser Val Phe Ile Phe 
    370                 375                 380                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
385                 390                 395                 400 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                405                 410                 415     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            420                 425                 430         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        435                 440                 445             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    450                 455                 460                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
465                 470                 475                 480 


<210>  16

<211>  1620

<212>  DNA

<213>  Artificial

<220>

<223> Complementary Strand of Coding Region of pDOW1196



<400>  16
aaataagact ttactcgaca actgttaatt agtagccgag catattacac accttaacac     60

tcgcctattg ttaaagtgtg tcctttgtct taaaattaga tgatcatcct ccattgaata    120

ctttgacttt gcaaactacc gccgttactg aaaacagcga cgaccgcaac gctggcggtt    180

gcgccaccgg gtccacgtcg acgtcctcag cccgggtcct gaccacttcg gaagcctctg    240

ggacagggag tggacgtgac agagaccacc aaggtagtca tcaatagtga cctcgaccta    300

ggccgtcggg ggtcccttcc ctgacctcac ctaacccata tagataatgt caccctcgtg    360

gttgatgttg gggagggagt tcttagctca gtggtataga catctgtgca ggttcttggt    420

caagagggac ttggactcca gacactggcg acgtctgtgc cggcacataa tgacacgcgc    480

tccttgcata ccgggtcggc ctctacgaaa actatagacc cccgttccct ggtgccagtg    540

gcagagcagc cggaggtgct ttccgggctc gcacaagggc gaccgcggtt cgaggttctc    600

gtggtcgccg ccgtggcggc gcgacccaac agagcagttt ctaatgaagg ggcttggcca    660

ctggcacagc accttgaggc cccgcgactg gtcgccacag gtatggaagg gacggcacga    720

ggtcaggagg ccggacataa gggactcgag ccaccactgg cacggcagca gctcgaaccc    780

gtgggtttgg atgtagacgt tgcagttggt attcgggagg ttgtgctttc aactgttcgc    840

gcaaatcatt actagatctt cctccattga atactttgac tttgcaaact accgccgtta    900

ctgaaaacag cgacgaccgc aacgctggcg gttgcgccac cggctgtagg tctactgggt    960

cagaggaagg tgggacagac gtagataacc tctgtctcag tggtagtgga cggcccggtc   1020

actcccataa atagtgacca accggaccat agtcgtcttc ggtccctttc ggggatttga   1080

ggactagata ttccggagat caaatcggtc accccggggt agttccaagt cgccgtcacc   1140

tagaccctgt ctaaagtgag agtggtagtc gtcggacgtc ggactactaa aacgttgaat   1200

aatgacggtt gttatatcat taataggcga gtgaaagccg cctccctggt tcgacctcta   1260

gtttgcacgc cagcggcggg gcagccaaaa gtaaaagggc ggtagcctac tcgtcgagtt   1320

cagcccgtgc cgctcgcacc agacggacga gttgttgaaa atgggcgcgc tccggttcca   1380

cgtcaccttc cagctgttgc gggacgtcag cccgttgtcg gtcctcagcc agtggctcgt   1440

cctatcgttc ctaaggtgga taagggagtc gagctgggac tgcgactcgt tccggctaat   1500

actcttcgta tttcaaatgc gaacacttca ctgggtggtc ccggactcgt cgggccactg   1560

gttcagcaaa ttagcgccgc tcacgattac tatcgagctc gggttttgct ttccgagtca   1620


<210>  17

<211>  1612

<212>  DNA

<213>  Artificial



<220>

<221>  CDS

<222>  (131)..(853)

<223>  Coding region of pDOW3716



<220>

<221>  CDS

<222>  (881)..(1594)

<223>  Coding region of pDOW3716



<400>  17
ctgaaatgag ctgttgacaa ttaatcatcg gctcgtataa tgtgtggaat tgtgagcgga     60

taacaatttc acacaggaaa cagaatttta atctactagt aggaggtaac ttatgaaact    120

gaaacgtttg atg gcg gca atg act ttt gtc gct gct ggc gtt gcg acc       169
           Met Ala Ala Met Thr Phe Val Ala Ala Gly Val Ala Thr          
           1               5                   10                       

gcc aac gcg gtg gcc cag gtg cag ctg cag gag tcg ggc cca gga ctg      217
Ala Asn Ala Val Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu         
    15                  20                  25                          

gtg aag cct tcg gag acc ctg tcc ctc acc tgc act gtc tct ggt ggt      265
Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly         
30                  35                  40                  45          

tcc atc agt agt tat cac tgg agc tgg atc cgg cag ccc cca ggg aag      313
Ser Ile Ser Ser Tyr His Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys         
                50                  55                  60              

gga ctg gag tgg att ggg tat atc tat tac agt ggg agc acc aac tac      361
Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr         
            65                  70                  75                  

aac ccc tcc ctc aag aat cga gtc acc ata tct gta gac acg tcc aag      409
Asn Pro Ser Leu Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys         
        80                  85                  90                      

aac cag ttc tcc ctg aac ctg agg tct gtg acc gct gca gac acg gcc      457
Asn Gln Phe Ser Leu Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala         
    95                  100                 105                         

gtg tat tac tgt gcg cga gga acg tat ggc cca gcc gga gat gct ttt      505
Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Gly Pro Ala Gly Asp Ala Phe         
110                 115                 120                 125         

gat atc tgg ggg caa ggg acc acg gtc acc gtc tcg tcg gcc tcc acg      553
Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr         
                130                 135                 140             

aaa ggc ccg agc gtg ttc ccg ctg gcg cca agc tcc aag agc acc agc      601
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser         
            145                 150                 155                 

ggc ggc acc gcc gcg ctg ggt tgt ctc gtc aaa gat tac ttc ccc gaa      649
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu         
        160                 165                 170                     

ccg gtg acc gtg tcg tgg aac tcc ggg gcg ctg acc agc ggt gtc cat      697
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His         
    175                 180                 185                         

acc ttc cct gcc gtg ctc cag tcc tcc ggc ctg tat tcc ctg agc tcg      745
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser         
190                 195                 200                 205         

gtg gtg acc gtg ccg tcg tcg agc ttg ggc acc caa acc tac atc tgc      793
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys         
                210                 215                 220             

aac gtc aac cat aag ccc tcc aac acg aaa gtt gac aag cgc gtt gag      841
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu         
            225                 230                 235                 

ccg aaa tcg tgc tagtgataat ctagaaggag gtaactt atg aaa ctg aaa cgt    895
Pro Lys Ser Cys                               Met Lys Leu Lys Arg       
        240                                               245           

ttg atg gcg gca atg act ttt gtc gct gct ggc gtt gcg acc gcc aac      943
Leu Met Ala Ala Met Thr Phe Val Ala Ala Gly Val Ala Thr Ala Asn         
            250                 255                 260                 

gcg gtg gcc gac atc cag atg acc cag tct cct tcc acc ctg tct gca      991
Ala Val Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala         
        265                 270                 275                     

tct att gga gac aga gtc acc atc acc tgc cgg gcc agt gag ggt att     1039
Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile         
    280                 285                 290                         

tat cac tgg ttg gcc tgg tat cag cag aag cca ggg aaa gcc cct aaa     1087
Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys         
295                 300                 305                 310         

ctc ctg atc tat aag gcc tct agt tta gcc agt ggg gcc cca tca agg     1135
Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg         
                315                 320                 325             

ttc agc ggc agt gga tct ggg aca gat ttc act ctc acc atc agc agc     1183
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser         
            330                 335                 340                 

ctg cag cct gat gat ttt gca act tat tac tgc caa caa tat agt aat     1231
Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn         
        345                 350                 355                     

tat ccg ctc act ttc ggc gga ggg acc aag ctg gag atc aaa cgt gcg     1279
Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala         
    360                 365                 370                         

gtc gcc gcc ccg tcg gtt ttc att ttc ccg cca tcg gat gag cag ctc     1327
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu         
375                 380                 385                 390         

aag tcg ggc acg gcg agc gtg gtc tgc ctg ctc aac aac ttt tac ccg     1375
Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro         
                395                 400                 405             

cgc gag gcc aag gtg cag tgg aag gtc gac aac gcc ctg cag tcg ggc     1423
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly         
            410                 415                 420                 

aac agc cag gag tcg gtc acc gag cag gat agc aag gat tcc acc tat     1471
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr         
        425                 430                 435                     

tcc ctc agc tcg acc ctg acg ctg agc aag gcc gat tat gag aag cat     1519
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His         
    440                 445                 450                         

aaa gtt tac gct tgt gaa gtg acc cac cag ggc ctg agc agc ccg gtg     1567
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val         
455                 460                 465                 470         

acc aag tcg ttt aat cgc ggc gag tgc taatgatagc tcgagccc             1612
Thr Lys Ser Phe Asn Arg Gly Glu Cys                                     
                475                                                     


<210>  18

<211>  479

<212>  PRT

<213>  Artificial

<220>

<223>  Amino Acid Sequence Corresponding to Coding region of pDOW3716



<400>  18

Met Ala Ala Met Thr Phe Val Ala Ala Gly Val Ala Thr Ala Asn Ala 
1               5                   10                  15      


Val Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser 
        35                  40                  45              


Ser Tyr His Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
65                  70                  75                  80  


Leu Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
                85                  90                  95      


Ser Leu Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Arg Gly Thr Tyr Gly Pro Ala Gly Asp Ala Phe Asp Ile Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Met Lys Leu Lys Arg Leu Met Ala Ala Met Thr Phe Val Ala Ala 
                245                 250                 255     


Gly Val Ala Thr Ala Asn Ala Val Ala Asp Ile Gln Met Thr Gln Ser 
            260                 265                 270         


Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys 
        275                 280                 285             


Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys 
    290                 295                 300                 


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala 
305                 310                 315                 320 


Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                325                 330                 335     


Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 
            340                 345                 350         


Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
        355                 360                 365             


Leu Glu Ile Lys Arg Ala Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    370                 375                 380                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
385                 390                 395                 400 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                405                 410                 415     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            420                 425                 430         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        435                 440                 445             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    450                 455                 460                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
465                 470                 475                 


<210>  19

<211>  1612

<212>  DNA

<213>  Artificial

<220>

<223>  Complementary Strand of Coding region of pDOW3716



<400>  19
gactttactc gacaactgtt aattagtagc cgagcatatt acacacctta acactcgcct     60

attgttaaag tgtgtccttt gtcttaaaat tagatgatca tcctccattg aatactttga    120

ctttgcaaac taccgccgtt actgaaaaca gcgacgaccg caacgctggc ggttgcgcca    180

ccgggtccac gtcgacgtcc tcagcccggg tcctgaccac ttcggaagcc tctgggacag    240

ggagtggacg tgacagagac caccaaggta gtcatcaata gtgacctcga cctaggccgt    300

cgggggtccc ttccctgacc tcacctaacc catatagata atgtcaccct cgtggttgat    360

gttggggagg gagttcttag ctcagtggta tagacatctg tgcaggttct tggtcaagag    420

ggacttggac tccagacact ggcgacgtct gtgccggcac ataatgacac gcgctccttg    480

cataccgggt cggcctctac gaaaactata gacccccgtt ccctggtgcc agtggcagag    540

cagccggagg tgctttccgg gctcgcacaa gggcgaccgc ggttcgaggt tctcgtggtc    600

gccgccgtgg cggcgcgacc caacagagca gtttctaatg aaggggcttg gccactggca    660

cagcaccttg aggccccgcg actggtcgcc acaggtatgg aagggacggc acgaggtcag    720

gaggccggac ataagggact cgagccacca ctggcacggc agcagctcga acccgtgggt    780

ttggatgtag acgttgcagt tggtattcgg gaggttgtgc tttcaactgt tcgcgcaact    840

cggctttagc acgatcacta ttagatcttc ctccattgaa tactttgact ttgcaaacta    900

ccgccgttac tgaaaacagc gacgaccgca acgctggcgg ttgcgccacc ggctgtaggt    960

ctactgggtc agaggaaggt gggacagacg tagataacct ctgtctcagt ggtagtggac   1020

ggcccggtca ctcccataaa tagtgaccaa ccggaccata gtcgtcttcg gtccctttcg   1080

gggatttgag gactagatat tccggagatc aaatcggtca ccccggggta gttccaagtc   1140

gccgtcacct agaccctgtc taaagtgaga gtggtagtcg tcggacgtcg gactactaaa   1200

acgttgaata atgacggttg ttatatcatt aataggcgag tgaaagccgc ctccctggtt   1260

cgacctctag tttgcacgcc agcggcgggg cagccaaaag taaaagggcg gtagcctact   1320

cgtcgagttc agcccgtgcc gctcgcacca gacggacgag ttgttgaaaa tgggcgcgct   1380

ccggttccac gtcaccttcc agctgttgcg ggacgtcagc ccgttgtcgg tcctcagcca   1440

gtggctcgtc ctatcgttcc taaggtggat aagggagtcg agctgggact gcgactcgtt   1500

ccggctaata ctcttcgtat ttcaaatgcg aacacttcac tgggtggtcc cggactcgtc   1560

gggccactgg ttcagcaaat tagcgccgct cacgattact atcgagctcg gg           1612


<210>  20

<211>  1639

<212>  DNA

<213>  Artificial



<220>

<221>  CDS

<222>  (131)..(880)

<223>  Coding region of pDOW3717



<220>

<221>  CDS

<222>  (908)..(1621)

<223>  Coding region of pDOW3717



<400>  20
ctgaaatgag ctgttgacaa ttaatcatcg gctcgtataa tgtgtggaat tgtgagcgga     60

taacaatttc acacaggaaa cagaatttta atctactagt aggaggtaac ttatgaaact    120

gaaacgtttg atg gcg gca atg act ttt gtc gct gct ggc gtt gcg acc       169
           Met Ala Ala Met Thr Phe Val Ala Ala Gly Val Ala Thr          
           1               5                   10                       

gcc aac gcg gtg gcc cag gtg cag ctg cag gag tcg ggc cca gga ctg      217
Ala Asn Ala Val Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu         
    15                  20                  25                          

gtg aag cct tcg gag acc ctg tcc ctc acc tgc act gtc tct ggt ggt      265
Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly         
30                  35                  40                  45          

tcc atc agt agt tat cac tgg agc tgg atc cgg cag ccc cca ggg aag      313
Ser Ile Ser Ser Tyr His Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys         
                50                  55                  60              

gga ctg gag tgg att ggg tat atc tat tac agt ggg agc acc aac tac      361
Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr         
            65                  70                  75                  

aac ccc tcc ctc aag aat cga gtc acc ata tct gta gac acg tcc aag      409
Asn Pro Ser Leu Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys         
        80                  85                  90                      

aac cag ttc tcc ctg aac ctg agg tct gtg acc gct gca gac acg gcc      457
Asn Gln Phe Ser Leu Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala         
    95                  100                 105                         

gtg tat tac tgt gcg cga gga acg tat ggc cca gcc gga gat gct ttt      505
Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Gly Pro Ala Gly Asp Ala Phe         
110                 115                 120                 125         

gat atc tgg ggg caa ggg acc acg gtc acc gtc tcg tcg gcc tcc acg      553
Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr         
                130                 135                 140             

aaa ggc ccg agc gtg ttc ccg ctg gcg cca agc tcc aag agc acc agc      601
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser         
            145                 150                 155                 

ggc ggc acc gcc gcg ctg ggt tgt ctc gtc aaa gat tac ttc ccc gaa      649
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu         
        160                 165                 170                     

ccg gtg acc gtg tcg tgg aac tcc ggg gcg ctg acc agc ggt gtc cat      697
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His         
    175                 180                 185                         

acc ttc cct gcc gtg ctc cag tcc tcc ggc ctg tat tcc ctg agc tcg      745
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser         
190                 195                 200                 205         

gtg gtg acc gtg ccg tcg tcg agc ttg ggc acc caa acc tac atc tgc      793
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys         
                210                 215                 220             

aac gtc aac cat aag ccc tcc aac acg aaa gtt gac aag cgc gtt gag      841
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu         
            225                 230                 235                 

ccg aaa tcg tgc gac aag acg cat acc tgc ccg ccg tgc tgatagtaat       890
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys                     
        240                 245                 250                     

ctagaaggag gtaactt atg aaa ctg aaa cgt ttg atg gcg gca atg act       940
                   Met Lys Leu Lys Arg Leu Met Ala Ala Met Thr          
                                   255                 260              

ttt gtc gct gct ggc gtt gcg acc gcc aac gcg gtg gcc gac atc cag      988
Phe Val Ala Ala Gly Val Ala Thr Ala Asn Ala Val Ala Asp Ile Gln         
            265                 270                 275                 

atg acc cag tct cct tcc acc ctg tct gca tct att gga gac aga gtc     1036
Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val         
        280                 285                 290                     

acc atc acc tgc cgg gcc agt gag ggt att tat cac tgg ttg gcc tgg     1084
Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp         
    295                 300                 305                         

tat cag cag aag cca ggg aaa gcc cct aaa ctc ctg atc tat aag gcc     1132
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala         
310                 315                 320                 325         

tct agt tta gcc agt ggg gcc cca tca agg ttc agc ggc agt gga tct     1180
Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser         
                330                 335                 340             

ggg aca gat ttc act ctc acc atc agc agc ctg cag cct gat gat ttt     1228
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe         
            345                 350                 355                 

gca act tat tac tgc caa caa tat agt aat tat ccg ctc act ttc ggc     1276
Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly         
        360                 365                 370                     

gga ggg acc aag ctg gag atc aaa cgt gcg gtc gcc gcc ccg tcg gtt     1324
Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Val Ala Ala Pro Ser Val         
    375                 380                 385                         

ttc att ttc ccg cca tcg gat gag cag ctc aag tcg ggc acg gcg agc     1372
Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser         
390                 395                 400                 405         

gtg gtc tgc ctg ctc aac aac ttt tac ccg cgc gag gcc aag gtg cag     1420
Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln         
                410                 415                 420             

tgg aag gtc gac aac gcc ctg cag tcg ggc aac agc cag gag tcg gtc     1468
Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val         
            425                 430                 435                 

acc gag cag gat agc aag gat tcc acc tat tcc ctc agc tcg acc ctg     1516
Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu         
        440                 445                 450                     

acg ctg agc aag gcc gat tat gag aag cat aaa gtt tac gct tgt gaa     1564
Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu         
    455                 460                 465                         

gtg acc cac cag ggc ctg agc agc ccg gtg acc aag tcg ttt aat cgc     1612
Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg         
470                 475                 480                 485         

ggc gag tgc taatgatagc tcgagccc                                     1639
Gly Glu Cys                                                             
                                                                        


<210>  21

<211>  488

<212>  PRT

<213>  Artificial

<220>

<223>  Amino Acid Sequence Corresponding to Coding region of pDOW3717



<400>  21

Met Ala Ala Met Thr Phe Val Ala Ala Gly Val Ala Thr Ala Asn Ala 
1               5                   10                  15      


Val Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser 
        35                  40                  45              


Ser Tyr His Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
65                  70                  75                  80  


Leu Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
                85                  90                  95      


Ser Leu Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Arg Gly Thr Tyr Gly Pro Ala Gly Asp Ala Phe Asp Ile Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Met Lys Leu Lys Arg Leu 
                245                 250                 255     


Met Ala Ala Met Thr Phe Val Ala Ala Gly Val Ala Thr Ala Asn Ala 
            260                 265                 270         


Val Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser 
        275                 280                 285             


Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr 
    290                 295                 300                 


His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
305                 310                 315                 320 


Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe 
                325                 330                 335     


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
            340                 345                 350         


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr 
        355                 360                 365             


Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Val 
    370                 375                 380                 


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
385                 390                 395                 400 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
                405                 410                 415     


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
            420                 425                 430         


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
        435                 440                 445             


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
    450                 455                 460                 


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
465                 470                 475                 480 


Lys Ser Phe Asn Arg Gly Glu Cys 
                485             


<210>  22

<211>  1639

<212>  DNA

<213>  Artificial

<220>

<223>  Complementary Strand of Coding region of pDOW3717



<400>  22
gactttactc gacaactgtt aattagtagc cgagcatatt acacacctta acactcgcct     60

attgttaaag tgtgtccttt gtcttaaaat tagatgatca tcctccattg aatactttga    120

ctttgcaaac taccgccgtt actgaaaaca gcgacgaccg caacgctggc ggttgcgcca    180

ccgggtccac gtcgacgtcc tcagcccggg tcctgaccac ttcggaagcc tctgggacag    240

ggagtggacg tgacagagac caccaaggta gtcatcaata gtgacctcga cctaggccgt    300

cgggggtccc ttccctgacc tcacctaacc catatagata atgtcaccct cgtggttgat    360

gttggggagg gagttcttag ctcagtggta tagacatctg tgcaggttct tggtcaagag    420

ggacttggac tccagacact ggcgacgtct gtgccggcac ataatgacac gcgctccttg    480

cataccgggt cggcctctac gaaaactata gacccccgtt ccctggtgcc agtggcagag    540

cagccggagg tgctttccgg gctcgcacaa gggcgaccgc ggttcgaggt tctcgtggtc    600

gccgccgtgg cggcgcgacc caacagagca gtttctaatg aaggggcttg gccactggca    660

cagcaccttg aggccccgcg actggtcgcc acaggtatgg aagggacggc acgaggtcag    720

gaggccggac ataagggact cgagccacca ctggcacggc agcagctcga acccgtgggt    780

ttggatgtag acgttgcagt tggtattcgg gaggttgtgc tttcaactgt tcgcgcaact    840

cggctttagc acgctgttct gcgtatggac gggcggcacg actatcatta gatcttcctc    900

cattgaatac tttgactttg caaactaccg ccgttactga aaacagcgac gaccgcaacg    960

ctggcggttg cgccaccggc tgtaggtcta ctgggtcaga ggaaggtggg acagacgtag   1020

ataacctctg tctcagtggt agtggacggc ccggtcactc ccataaatag tgaccaaccg   1080

gaccatagtc gtcttcggtc cctttcgggg atttgaggac tagatattcc ggagatcaaa   1140

tcggtcaccc cggggtagtt ccaagtcgcc gtcacctaga ccctgtctaa agtgagagtg   1200

gtagtcgtcg gacgtcggac tactaaaacg ttgaataatg acggttgtta tatcattaat   1260

aggcgagtga aagccgcctc cctggttcga cctctagttt gcacgccagc ggcggggcag   1320

ccaaaagtaa aagggcggta gcctactcgt cgagttcagc ccgtgccgct cgcaccagac   1380

ggacgagttg ttgaaaatgg gcgcgctccg gttccacgtc accttccagc tgttgcggga   1440

cgtcagcccg ttgtcggtcc tcagccagtg gctcgtccta tcgttcctaa ggtggataag   1500

ggagtcgagc tgggactgcg actcgttccg gctaatactc ttcgtatttc aaatgcgaac   1560

acttcactgg gtggtcccgg actcgtcggg ccactggttc agcaaattag cgccgctcac   1620

gattactatc gagctcggg                                                1639


