                         SEQUENCE LISTING

<110>  Boehringer Ingelheim International, GmbH and Syntonix Pharmaceuticals, Inc.
 
<120>  NATRIURETIC FUSION PROTEINS

<130>  1

<160>  36    

<170>  PatentIn version 3.2

<210>  1
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  IgG hinge region sequence

<400>  1

Cys Pro Pro Cys Pro 
1               5   


<210>  2
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  L3

<400>  2

Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   


<210>  3
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  L4

<400>  3

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10      


<210>  4
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  Linker

<400>  4

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  


<210>  5
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  L5a

<400>  5

Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


<210>  6
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  L5

<400>  6

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


<210>  7
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  L6

<400>  7

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  8
<211>  261
<212>  PRT
<213>  artificial

<220>
<223>  ANPxy-L4-Fc1ab (protein)


<220>
<221>  MISC_FEATURE
<222>  (1)..(261)
<223>  the protein may dimerize

<400>  8

Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly Gly Ser Gly 
            20                  25                  30          


Gly Ser Gly Gly Ser Gly Gly Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        35                  40                  45              


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    50                  55                  60                  


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
65                  70                  75                  80  


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                85                  90                  95      


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            100                 105                 110         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        115                 120                 125             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    130                 135                 140                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
145                 150                 155                 160 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                165                 170                 175     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            180                 185                 190         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        195                 200                 205             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    210                 215                 220                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
225                 230                 235                 240 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                245                 250                 255     


Leu Ser Pro Gly Lys 
            260     


<210>  9
<211>  270
<212>  PRT
<213>  artificial

<220>
<223>  ANPxy-L6-Fc1ab (protein)


<220>
<221>  MISC_FEATURE
<222>  (1)..(270)
<223>  the protein may dimerize

<400>  9

Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly Gly Ser Gly 
            20                  25                  30          


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        35                  40                  45              


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    50                  55                  60                  


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
65                  70                  75                  80  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                85                  90                  95      


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            100                 105                 110         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        115                 120                 125             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    130                 135                 140                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
145                 150                 155                 160 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                165                 170                 175     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            180                 185                 190         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        195                 200                 205             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    210                 215                 220                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
225                 230                 235                 240 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                245                 250                 255     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 265                 270 


<210>  10
<211>  260
<212>  PRT
<213>  artificial

<220>
<223>  ANPxy-L4-Fc2ab (protein)


<220>
<221>  MISC_FEATURE
<222>  (1)..(260)
<223>  the protein may dimerize

<400>  10

Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly Gly Ser Gly 
            20                  25                  30          


Gly Ser Gly Gly Ser Gly Gly Cys Pro Pro Cys Pro Ala Pro Pro Val 
        35                  40                  45              


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    50                  55                  60                  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
65                  70                  75                  80  


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
                85                  90                  95      


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
            100                 105                 110         


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
        115                 120                 125             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
    130                 135                 140                 


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
145                 150                 155                 160 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                165                 170                 175     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            180                 185                 190         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        195                 200                 205             


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    210                 215                 220                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
225                 230                 235                 240 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                245                 250                 255     


Ser Pro Gly Lys 
            260 


<210>  11
<211>  269
<212>  PRT
<213>  artificial

<220>
<223>  ANPxy-L6-Fc2ab


<220>
<221>  MISC_FEATURE
<222>  (1)..(269)
<223>  the protein may dimerize

<400>  11

Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly Gly Ser Gly 
            20                  25                  30          


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        35                  40                  45              


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
    50                  55                  60                  


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
65                  70                  75                  80  


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
                85                  90                  95      


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
            100                 105                 110         


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
        115                 120                 125             


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    130                 135                 140                 


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
145                 150                 155                 160 


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                165                 170                 175     


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
            180                 185                 190         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        195                 200                 205             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
    210                 215                 220                 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
225                 230                 235                 240 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                245                 250                 255     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 265                 


<210>  12
<211>  251
<212>  PRT
<213>  artificial

<220>
<223>  ANPxy-L2-Fc1ab (protein)


<220>
<221>  MISC_FEATURE
<222>  (1)..(251)
<223>  the protein may dimerize

<400>  12

Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly Gly Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
        35                  40                  45              


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    50                  55                  60                  


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
65                  70                  75                  80  


Trp Tyr Val Asp Gly Met Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                85                  90                  95      


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
            100                 105                 110         


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        115                 120                 125             


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
    130                 135                 140                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
145                 150                 155                 160 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                165                 170                 175     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            180                 185                 190         


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
        195                 200                 205             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    210                 215                 220                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
225                 230                 235                 240 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250     


<210>  13
<211>  260
<212>  PRT
<213>  artificial

<220>
<223>  ANPxy-L4-Fc1ab (protein)-2


<220>
<221>  MISC_FEATURE
<222>  (1)..(260)
<223>  the protein may dimerize

<400>  13

Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly Gly Ser Gly 
            20                  25                  30          


Gly Ser Gly Gly Ser Gly Gly Cys Pro Pro Cys Pro Ala Pro Pro Val 
        35                  40                  45              


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    50                  55                  60                  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
65                  70                  75                  80  


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
                85                  90                  95      


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
            100                 105                 110         


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
        115                 120                 125             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
    130                 135                 140                 


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
145                 150                 155                 160 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                165                 170                 175     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            180                 185                 190         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        195                 200                 205             


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    210                 215                 220                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
225                 230                 235                 240 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                245                 250                 255     


Ser Pro Gly Lys 
            260 


<210>  14
<211>  222
<212>  PRT
<213>  artificial

<220>
<223>  Fc1AB

<400>  14

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220         


<210>  15
<211>  28
<212>  PRT
<213>  artificial

<220>
<223>  hANP28

<400>  15

Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
            20                  25              


<210>  16
<211>  32
<212>  PRT
<213>  artificial

<220>
<223>  hBNP32

<400>  16

Ser Pro Lys Met Val Gln Gly Ser Gly Cys Phe Gly Arg Lys Met Asp 
1               5                   10                  15      


Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys Lys Val Leu Arg Arg His 
            20                  25                  30          


<210>  17
<211>  221
<212>  PRT
<213>  artificial

<220>
<223>  Fc2AB

<400>  17

Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
1               5                   10                  15      


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            20                  25                  30          


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
        35                  40                  45              


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    50                  55                  60                  


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
65                  70                  75                  80  


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                85                  90                  95      


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            100                 105                 110         


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        115                 120                 125             


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    130                 135                 140                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
145                 150                 155                 160 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
                165                 170                 175     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        195                 200                 205             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220     


<210>  18
<211>  239
<212>  PRT
<213>  artificial

<220>
<223>  CysFc-004

<400>  18

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                165                 170                 175     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            180                 185                 190         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        195                 200                 205             


Arg Trp Gln Gln Gly Asn Phe Ser Cys Ser Val Met His Glu Ala Leu 
    210                 215                 220                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235                 


<210>  19
<211>  30
<212>  PRT
<213>  artificial

<220>
<223>  Peptide A

<400>  19

Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly Gly 
            20                  25                  30  


<210>  20
<211>  39
<212>  PRT
<213>  artificial

<220>
<223>  Peptide B

<400>  20

Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly Gly Ser Gly 
            20                  25                  30          


Gly Ser Gly Gly Ser Gly Gly 
        35                  


<210>  21
<211>  44
<212>  PRT
<213>  artificial

<220>
<223>  Peptide C

<400>  21

Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        35                  40                  


<210>  22
<211>  28
<212>  PRT
<213>  artificial

<220>
<223>  Peptide D

<400>  22

Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
            20                  25              


<210>  23
<211>  37
<212>  PRT
<213>  artificial

<220>
<223>  Peptide E

<400>  23

Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Leu Arg Arg Ser Ser Cys 
1               5                   10                  15      


Phe Gly Gly Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys 
            20                  25                  30          


Asn Ser Phe Arg Tyr 
        35          


<210>  24
<211>  843
<212>  DNA
<213>  artificial

<220>
<223>  ANPxy-L4-Fc1ab (nucleotide) + signal sequence

<400>  24
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt     60

agcctgcgga gatccagctg cttcgggggc aggatggaca ggattggagc ccagagcgga    120

ctgggctgta acagcttccg gtacggcgga tccggcgggt ccggcggatc cggcggatgc    180

ccaccgtgcc cagctccgga actgctgggc ggaccgtcag tcttcctctt ccccccaaaa    240

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg    300

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat    360

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc    420

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa    480

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca    540

caggtgtaca ccctgccccc atcccgcgat gagctgacca agaaccaggt cagcctgacc    600

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag    660

ccggagaaca actacaagac cacgcctccc gtgttggact ccgacggctc cttcttcctc    720

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc    780

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt    840

aaa                                                                  843


<210>  25
<211>  281
<212>  PRT
<213>  artificial

<220>
<223>  ANPxy-L4-Fc1ab (protein) + signal sequence

<400>  25

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met 
            20                  25                  30          


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
        35                  40                  45              


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Cys Pro Pro Cys Pro 
    50                  55                  60                  


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
65                  70                  75                  80  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            100                 105                 110         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        115                 120                 125             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    130                 135                 140                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
145                 150                 155                 160 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                165                 170                 175     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            180                 185                 190         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        195                 200                 205             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    210                 215                 220                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
225                 230                 235                 240 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                245                 250                 255     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            260                 265                 270         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        275                 280     


<210>  26
<211>  870
<212>  DNA
<213>  artificial

<220>
<223>  ANPxy-L6-Fc1ab (nucleotide) + signal sequence

<400>  26
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt     60

agcctgcgga gatccagctg cttcgggggc aggatggaca ggattggagc ccagagcgga    120

ctgggctgta acagcttccg gtacggcgga tccggcgggt ccggcggctc cggcggctcc    180

ggcgggtccg gcggatccgg cggatgccca ccgtgcccag ctccggaact gctgggcgga    240

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    300

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    360

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac    420

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    480

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    540

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgcgatgag    600

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    660

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    720

ttggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    780

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    840

cagaagagcc tctccctgtc tccgggtaaa                                     870


<210>  27
<211>  290
<212>  PRT
<213>  artificial

<220>
<223>  ANPxy-L6-Fc1ab (protein) + signal sequence

<400>  27

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met 
            20                  25                  30          


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
        35                  40                  45              


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    50                  55                  60                  


Gly Ser Gly Gly Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    130                 135                 140                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  28
<211>  840
<212>  DNA
<213>  artificial

<220>
<223>  ANPxy-L4-Fc2ab (nucleotide) + signal sequence

<400>  28
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt     60

agcctgcgga gatccagctg cttcgggggc aggatggaca ggattggagc ccagagcgga    120

ctgggctgta acagcttccg gtacggcgga tccggcgggt ccggcggatc cggcggatgc    180

ccaccttgcc cagcaccacc tgtggcagga ccttcagtct tcctcttccc cccaaaaccc    240

aaggacaccc tgatgatctc cagaacccct gaggtcacgt gcgtggtggt ggacgtgagc    300

cacgaagacc ccgaggtcca gttcaactgg tacgtggacg gcgtggaggt gcataatgcc    360

aagacaaagc cacgggagga gcagttcaac agcacgttcc gtgtggtcag cgtcctcacc    420

gtcgtgcacc aggactggct gaacggcaag gagtacaagt gcaaggtctc caacaaaggc    480

ctcccagccc ccatcgagaa aaccatctcc aaaaccaaag ggcagccccg agaaccacag    540

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc    600

ctggtcaaag gcttctaccc cagcgacatc gccgtggagt gggagagcaa tgggcagccg    660

gagaacaact acaagaccac acctcccatg ctggactccg acggctcctt cttcctctac    720

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg    780

atgcatgagg ctctgcacaa ccactacaca cagaagagcc tctccctgtc tccgggtaaa    840


<210>  29
<211>  280
<212>  PRT
<213>  artificial

<220>
<223>  ANPxy-L4-Fc2ab (protein) + signal sequence

<400>  29

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met 
            20                  25                  30          


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
        35                  40                  45              


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Cys Pro Pro Cys Pro 
    50                  55                  60                  


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
65                  70                  75                  80  


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                85                  90                  95      


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            100                 105                 110         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        115                 120                 125             


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
    130                 135                 140                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
145                 150                 155                 160 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
                165                 170                 175     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
            180                 185                 190         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        195                 200                 205             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    210                 215                 220                 


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
225                 230                 235                 240 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                245                 250                 255     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            260                 265                 270         


Ser Leu Ser Leu Ser Pro Gly Lys 
        275                 280 


<210>  30
<211>  867
<212>  DNA
<213>  artificial

<220>
<223>  ANPxy-L6-Fc2ab (nucleotide) + signal sequence

<400>  30
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt     60

agcctgcgga gatccagctg cttcgggggc aggatggaca ggattggagc ccagagcgga    120

ctgggctgta acagcttccg gtacggcgga tccggcgggt ccggcggctc cggcggctcc    180

ggcgggtccg gcggatccgg cggatgccca ccttgcccag caccacctgt ggcaggacct    240

tcagtcttcc tcttcccccc aaaacccaag gacaccctga tgatctccag aacccctgag    300

gtcacgtgcg tggtggtgga cgtgagccac gaagaccccg aggtccagtt caactggtac    360

gtggacggcg tggaggtgca taatgccaag acaaagccac gggaggagca gttcaacagc    420

acgttccgtg tggtcagcgt cctcaccgtc gtgcaccagg actggctgaa cggcaaggag    480

tacaagtgca aggtctccaa caaaggcctc ccagccccca tcgagaaaac catctccaaa    540

accaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg    600

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc    660

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacacc tcccatgctg    720

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag    780

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacacag    840

aagagcctct ccctgtctcc gggtaaa                                        867


<210>  31
<211>  289
<212>  PRT
<213>  artificial

<220>
<223>  ANPxy-L6-Fc2ab (protein) + signal sequence

<400>  31

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met 
            20                  25                  30          


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
        35                  40                  45              


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    50                  55                  60                  


Gly Ser Gly Gly Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
65                  70                  75                  80  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                85                  90                  95      


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            100                 105                 110         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        115                 120                 125             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val 
    130                 135                 140                 


Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu 
145                 150                 155                 160 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys 
                165                 170                 175     


Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            180                 185                 190         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        195                 200                 205             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    210                 215                 220                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu 
225                 230                 235                 240 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                245                 250                 255     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            260                 265                 270         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        275                 280                 285             


Lys 
    


<210>  32
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  mouse IgG kappa light chain signal sequence

<400>  32

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Pro Gly Ser Thr Gly 
1               5                   10                  15  


<210>  33
<211>  783
<212>  DNA
<213>  ANPxy-L4-Fc1ab (nucleotide)

<400>  33
agcctgcgga gatccagctg cttcgggggc aggatggaca ggattggagc ccagagcgga     60

ctgggctgta acagcttccg gtacggcgga tccggcgggt ccggcggatc cggcggatgc    120

ccaccgtgcc cagctccgga actgctgggc ggaccgtcag tcttcctctt ccccccaaaa    180

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg    240

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat    300

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc    360

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa    420

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca    480

caggtgtaca ccctgccccc atcccgcgat gagctgacca agaaccaggt cagcctgacc    540

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag    600

ccggagaaca actacaagac cacgcctccc gtgttggact ccgacggctc cttcttcctc    660

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc    720

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt    780

aaa                                                                  783


<210>  34
<211>  810
<212>  DNA
<213>  artificial

<220>
<223>  ANPxy-L6-Fc1ab (nucleotide)

<400>  34
agcctgcgga gatccagctg cttcgggggc aggatggaca ggattggagc ccagagcgga     60

ctgggctgta acagcttccg gtacggcgga tccggcgggt ccggcggctc cggcggctcc    120

ggcgggtccg gcggatccgg cggatgccca ccgtgcccag ctccggaact gctgggcgga    180

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    240

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    300

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac    360

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    420

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    480

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgcgatgag    540

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    600

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    660

ttggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    720

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    780

cagaagagcc tctccctgtc tccgggtaaa                                     810


<210>  35
<211>  780
<212>  DNA
<213>  artificial

<220>
<223>  ANPxy-L4-Fc2ab (nucleotide)

<400>  35
agcctgcgga gatccagctg cttcgggggc aggatggaca ggattggagc ccagagcgga     60

ctgggctgta acagcttccg gtacggcgga tccggcgggt ccggcggatc cggcggatgc    120

ccaccttgcc cagcaccacc tgtggcagga ccttcagtct tcctcttccc cccaaaaccc    180

aaggacaccc tgatgatctc cagaacccct gaggtcacgt gcgtggtggt ggacgtgagc    240

cacgaagacc ccgaggtcca gttcaactgg tacgtggacg gcgtggaggt gcataatgcc    300

aagacaaagc cacgggagga gcagttcaac agcacgttcc gtgtggtcag cgtcctcacc    360

gtcgtgcacc aggactggct gaacggcaag gagtacaagt gcaaggtctc caacaaaggc    420

ctcccagccc ccatcgagaa aaccatctcc aaaaccaaag ggcagccccg agaaccacag    480

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc    540

ctggtcaaag gcttctaccc cagcgacatc gccgtggagt gggagagcaa tgggcagccg    600

gagaacaact acaagaccac acctcccatg ctggactccg acggctcctt cttcctctac    660

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg    720

atgcatgagg ctctgcacaa ccactacaca cagaagagcc tctccctgtc tccgggtaaa    780


<210>  36
<211>  807
<212>  DNA
<213>  artificial

<220>
<223>  ANPxy-L6-Fc2ab (nucleotide)

<400>  36
agcctgcgga gatccagctg cttcgggggc aggatggaca ggattggagc ccagagcgga     60

ctgggctgta acagcttccg gtacggcgga tccggcgggt ccggcggctc cggcggctcc    120

ggcgggtccg gcggatccgg cggatgccca ccttgcccag caccacctgt ggcaggacct    180

tcagtcttcc tcttcccccc aaaacccaag gacaccctga tgatctccag aacccctgag    240

gtcacgtgcg tggtggtgga cgtgagccac gaagaccccg aggtccagtt caactggtac    300

gtggacggcg tggaggtgca taatgccaag acaaagccac gggaggagca gttcaacagc    360

acgttccgtg tggtcagcgt cctcaccgtc gtgcaccagg actggctgaa cggcaaggag    420

tacaagtgca aggtctccaa caaaggcctc ccagccccca tcgagaaaac catctccaaa    480

accaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg    540

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc    600

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacacc tcccatgctg    660

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag    720

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacacag    780

aagagcctct ccctgtctcc gggtaaa                                        807


