                         SEQUENCE LISTING

<110>  The University of Chicago
       Chang, et al.
 
<120>  Materials and Methods for Modulating Protective Pathways in 
       Epithelial Cells

<130>  27373/42212A

<150>  US 60/942,946
<151>  2007-06-08

<160>  22     

<170>  PatentIn version 3.5

<210>  1
<211>  40
<212>  PRT
<213>  Bacillus subtilis

<220>
<221> 
<223>  B. subtilis Competence and Sporulation Factor (CSF) precursor

<400>  1

Met Lys Leu Lys Ser Lys Leu Phe Val Ile Cys Leu Ala Ala Ala Ala 
1               5                   10                  15      


Ile Phe Thr Ala Ala Gly Val Ser Ala Asn Ala Glu Ala Leu Asp Phe 
            20                  25                  30          


His Val Thr Glu Arg Gly Met Thr 
        35                  40  


<210>  2
<211>  5
<212>  PRT
<213>  Bacillus subtilis

<220>
<221> 
<223>  B. subtilis Competence and Sporulation Factor

<400>  2

Glu Arg Gly Met Thr 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Bacillus subtilis

<220>
<221> 
<223>  B. subtilis Competence and Sporulation Facotr scrambled peptide

<400>  3

Glu Met Thr Arg Gly 
1               5   


<210>  4
<211>  3252
<212>  DNA
<213>  Homo sapiens

<220>
<221> 
<223>  Human OCTN2 polynucleotide

<400>  4
gcggcccagg cccgcaacct tccctggtcg tgcgccctat gtaaggccag ccgcggcagg     60

accaaggcgg cggtgtcagc tcgcgagcct accctccgcg gacggtcttg ggtcgcctgc    120

tgcctggctt gcctggtcgg cggcgggtgc cccgcgcgca cgcgcaaagc ccgccgcgtt    180

ccccgacccc aggccgcgct ctgtgggcct ctgagggcgg catgcgggac tacgacgagg    240

tgaccgcctt cctgggcgag tgggggccct tccagcgcct catcttcttc ctgctcagcg    300

ccagcatcat ccccaatggc ttcaccggcc tgtcctccgt gttcctgata gcgaccccgg    360

agcaccgctg ccgggtgccg gacgccgcga acctgagcag cgcctggcgc aaccacactg    420

tcccactgcg gctgcgggac ggccgcgagg tgccccacag ctgccgccgc taccggctcg    480

ccaccatcgc caacttctcg gcgcttgggc tggagccggg gcgcgacgtg gacctggggc    540

agctggagca ggagagctgt ctggatggct gggagttcag tcaggacgtc tacctgtcca    600

ccattgtgac cgagtggaac ctggtgtgtg aggacgactg gaaggcccca ctcacaatct    660

ccttgttctt cgtgggtgtg ctgttgggct ccttcatttc agggcagctg tcagacaggt    720

ttggccggaa gaatgtgctg ttcgtgacca tgggcatgca gacaggcttc agcttcctgc    780

agatcttctc gaagaatttt gagatgtttg tcgtgctgtt tgtccttgta ggcatgggcc    840

agatctccaa ctatgtggca gcatttgtcc tggggacaga aattcttggc aagtcagttc    900

gtataatatt ctctacgtta ggagtgtgca tattttatgc atttggctac atggtgctgc    960

cactgtttgc ttacttcatc cgagactggc ggatgctgct ggtggcgctg acgatgccgg   1020

gggtgctatg cgtggcactc tggtggttca tccctgagtc cccccgatgg ctcatctctc   1080

agggacgatt tgaagaggca gaggtgatca tccgcaaggc tgccaaagcc aatgggattg   1140

ttgtgccttc cactatcttt gacccgagtg agttacaaga cctaagttcc aagaagcagc   1200

agtcccacaa cattctggat ctgcttcgaa cctggaatat ccggatggtc accatcatgt   1260

ccataatgct gtggatgacc atatcagtgg gctattttgg gctttcgctt gatactccta   1320

acttgcatgg ggacatcttt gtgaactgct tcctttcagc gatggttgaa gtcccagcat   1380

atgtgttggc ctggctgctg ctgcaatatt tgccccggcg ctattccatg gccactgccc   1440

tcttcctggg tggcagtgtc cttctcttca tgcagctggt acccccagac ttgtattatt   1500

tggctacagt cctggtgatg gtgggcaagt ttggagtcac ggctgccttt tccatggtct   1560

acgtgtacac agccgagctg tatcccacag tggtgagaaa catgggtgtg ggagtcagct   1620

ccacagcatc ccgcctgggc agcatcctgt ctccctactt cgtttacctt ggtgcctacg   1680

accgcttcct gccctacatt ctcatgggaa gtctgaccat cctgacagcc atcctcacct   1740

tgtttctccc agagagcttc ggtaccccac tcccagacac cattgaccag atgctaagag   1800

tcaaaggaat gaaacacaga aaaactccaa gtcacacaag gatgttaaaa gatggtcaag   1860

aaaggcccac aatccttaaa agcacagcct tctaacatcg cttccagtaa gggagaaact   1920

gaagaggaaa gactgtcttg ccagaaatgg ccagcttgtg cagactccga gtccttcagt   1980

gacaaaggcc tttgctgttt gtcctcttga cctgtgtctg acttgctcct ggatgggcac   2040

ccacactcag aggctacata tggccctaga gcaccacctt cctctaggga cactggggct   2100

acctacagac aacttcatct aagtcctaac tattacaatg atggactcag cacctccaaa   2160

gcagttaatt tttcactaga accagtgaga tctggaggaa tgtgagaagc atatgctaaa   2220

tgtacatttt aattttagac tacttgaaaa ggcccctaat aaggctagag gtctaagtcc   2280

cccacccctt tccccactcc cctctagtgg tgaactttag aggaaaagga agtaattgca   2340

caaggagttt gattcttacc ttttctcagt tacagaggac attaactgga tcattgcttc   2400

cccagggcag gagagcgcag agctagggaa agtgaaaggt aatgaagatg gagcagaatg   2460

agcagatgca gatcaccagc aaagtgcact gatgtgtgag ctcttaagac cactcagcat   2520

gacgactgag tagacttgtt tacatctgat caaagcactg ggcttgtcca ggctcataat   2580

aaatgctcca ttgaatctac tattcttgtt ttccactgct gtggaaacct ccttgctact   2640

atagcgtctt atgtatggtt taaaggaaat ttatcaggtg agagagatga gcaacgttgt   2700

cttttctctc aaagctgtaa tgtgggtttt gttttattgt ttatttgttt gttgttgtat   2760

ccttttctcc ttgttatttg cccttcagaa tgcacttggg aaaggctggt tccttagcct   2820

cctggtttgt gtcttttttt tttttttttt aaacacagaa tcactctggc aattgtctgc   2880

agctgccact ggtgcaaggc cttaccagcc ctagcctcta gcacttctct aagtgccaaa   2940

aacagtgtca ttgtgtgtgt tcctttcttg atacttagtc atgggaggat attacaaaaa   3000

agaaatttaa attgtgttca tagtctttca gagtagctca ctttagtcct gtaactttat   3060

tgggtgatat tttgtgttca gtgtaattgt cttctctttg ctgattatgt taccatggta   3120

ctcctaaagc atatgcctca cctggttaaa aaagaacaaa catgtttttg tgaaagctac   3180

tgaagtgcct tgggaaatga gaaagtttta ataagtaaaa tgatttttta aatatcaaaa   3240

aaaaaaaaaa aa                                                       3252


<210>  5
<211>  557
<212>  PRT
<213>  Homo sapiens

<220>
<221> 
<223>  Human OCTN2 polypeptide

<400>  5

Met Arg Asp Tyr Asp Glu Val Thr Ala Phe Leu Gly Glu Trp Gly Pro 
1               5                   10                  15      


Phe Gln Arg Leu Ile Phe Phe Leu Leu Ser Ala Ser Ile Ile Pro Asn 
            20                  25                  30          


Gly Phe Thr Gly Leu Ser Ser Val Phe Leu Ile Ala Thr Pro Glu His 
        35                  40                  45              


Arg Cys Arg Val Pro Asp Ala Ala Asn Leu Ser Ser Ala Trp Arg Asn 
    50                  55                  60                  


His Thr Val Pro Leu Arg Leu Arg Asp Gly Arg Glu Val Pro His Ser 
65                  70                  75                  80  


Cys Arg Arg Tyr Arg Leu Ala Thr Ile Ala Asn Phe Ser Ala Leu Gly 
                85                  90                  95      


Leu Glu Pro Gly Arg Asp Val Asp Leu Gly Gln Leu Glu Gln Glu Ser 
            100                 105                 110         


Cys Leu Asp Gly Trp Glu Phe Ser Gln Asp Val Tyr Leu Ser Thr Ile 
        115                 120                 125             


Val Thr Glu Trp Asn Leu Val Cys Glu Asp Asp Trp Lys Ala Pro Leu 
    130                 135                 140                 


Thr Ile Ser Leu Phe Phe Val Gly Val Leu Leu Gly Ser Phe Ile Ser 
145                 150                 155                 160 


Gly Gln Leu Ser Asp Arg Phe Gly Arg Lys Asn Val Leu Phe Val Thr 
                165                 170                 175     


Met Gly Met Gln Thr Gly Phe Ser Phe Leu Gln Ile Phe Ser Lys Asn 
            180                 185                 190         


Phe Glu Met Phe Val Val Leu Phe Val Leu Val Gly Met Gly Gln Ile 
        195                 200                 205             


Ser Asn Tyr Val Ala Ala Phe Val Leu Gly Thr Glu Ile Leu Gly Lys 
    210                 215                 220                 


Ser Val Arg Ile Ile Phe Ser Thr Leu Gly Val Cys Ile Phe Tyr Ala 
225                 230                 235                 240 


Phe Gly Tyr Met Val Leu Pro Leu Phe Ala Tyr Phe Ile Arg Asp Trp 
                245                 250                 255     


Arg Met Leu Leu Val Ala Leu Thr Met Pro Gly Val Leu Cys Val Ala 
            260                 265                 270         


Leu Trp Trp Phe Ile Pro Glu Ser Pro Arg Trp Leu Ile Ser Gln Gly 
        275                 280                 285             


Arg Phe Glu Glu Ala Glu Val Ile Ile Arg Lys Ala Ala Lys Ala Asn 
    290                 295                 300                 


Gly Ile Val Val Pro Ser Thr Ile Phe Asp Pro Ser Glu Leu Gln Asp 
305                 310                 315                 320 


Leu Ser Ser Lys Lys Gln Gln Ser His Asn Ile Leu Asp Leu Leu Arg 
                325                 330                 335     


Thr Trp Asn Ile Arg Met Val Thr Ile Met Ser Ile Met Leu Trp Met 
            340                 345                 350         


Thr Ile Ser Val Gly Tyr Phe Gly Leu Ser Leu Asp Thr Pro Asn Leu 
        355                 360                 365             


His Gly Asp Ile Phe Val Asn Cys Phe Leu Ser Ala Met Val Glu Val 
    370                 375                 380                 


Pro Ala Tyr Val Leu Ala Trp Leu Leu Leu Gln Tyr Leu Pro Arg Arg 
385                 390                 395                 400 


Tyr Ser Met Ala Thr Ala Leu Phe Leu Gly Gly Ser Val Leu Leu Phe 
                405                 410                 415     


Met Gln Leu Val Pro Pro Asp Leu Tyr Tyr Leu Ala Thr Val Leu Val 
            420                 425                 430         


Met Val Gly Lys Phe Gly Val Thr Ala Ala Phe Ser Met Val Tyr Val 
        435                 440                 445             


Tyr Thr Ala Glu Leu Tyr Pro Thr Val Val Arg Asn Met Gly Val Gly 
    450                 455                 460                 


Val Ser Ser Thr Ala Ser Arg Leu Gly Ser Ile Leu Ser Pro Tyr Phe 
465                 470                 475                 480 


Val Tyr Leu Gly Ala Tyr Asp Arg Phe Leu Pro Tyr Ile Leu Met Gly 
                485                 490                 495     


Ser Leu Thr Ile Leu Thr Ala Ile Leu Thr Leu Phe Leu Pro Glu Ser 
            500                 505                 510         


Phe Gly Thr Pro Leu Pro Asp Thr Ile Asp Gln Met Leu Arg Val Lys 
        515                 520                 525             


Gly Met Lys His Arg Lys Thr Pro Ser His Thr Arg Met Leu Lys Asp 
    530                 535                 540                 


Gly Gln Glu Arg Pro Thr Ile Leu Lys Ser Thr Ala Phe 
545                 550                 555         


<210>  6
<211>  2214
<212>  DNA
<213>  Homo sapiens

<220>
<221> 
<223>  Human OCTN1 polynucleotide

<400>  6
cctgtttccc aggaacggtc cccggcttcg cgccccaatt tctaacagcc tgcctgtccc     60

ccgggaacgt tctaacatcc ttggggagcg ccccagctac aagacactgt cctgagaacg    120

ctgtcatcac ccgtagttgc aagtttcgga gcggcagtgg gaagcatgcg ggactacgac    180

gaggtgatcg ccttcctggg cgagtggggg cccttccagc gcctcatctt cttcctgctc    240

agcgccagca tcatccccaa tggcttcaat ggtatgtcag tcgtgttcct ggcggggacc    300

ccggagcacc gctgtcgagt gccggacgcc gcgaacctga gcagcgcctg gcgcaacaac    360

agtgtcccgc tgcggctgcg ggacggccgc gaggtgcccc acagctgcag ccgctaccgg    420

ctcgccacca tcgccaactt ctcggcgctc gggctggagc cggggcgcga cgtggacctg    480

gggcagctgg agcaggagag ctgcctggat ggctgggagt tcagccagga cgtctacctg    540

tccaccgtcg tgaccgagtg gaatctggtg tgtgaggaca actggaaggt gcccctcacc    600

acctccctgt tcttcgtagg cgtgctcctc ggctccttcg tgtccgggca gctgtcagac    660

aggtttggca ggaagaacgt tctcttcgca accatggctg tacagactgg cttcagcttc    720

ctgcagattt tctccatcag ctgggagatg ttcactgtgt tatttgtcat cgtgggcatg    780

ggccagatct ccaactatgt ggtagccttc atactaggaa cagaaattct tggcaagtca    840

gttcgtatta tattctctac attaggagtg tgcacatttt ttgcagttgg ctatatgctg    900

ctgccactgt ttgcttactt catcagagac tggcggatgc tgctgctggc gctgacggtg    960

ccgggagtgc tgtgtgtccc gctgtggtgg ttcattcctg aatctccccg atggctgata   1020

tcccagagaa gatttagaga ggctgaagat atcatccaaa aagctgcaaa aatgaacaac   1080

atagctgtac cagcagtgat atttgattct gtggaggagc taaatcccct gaagcagcag   1140

aaagctttca ttctggacct gttcaggact cggaatattg ccataatgac cattatgtct   1200

ttgctgctat ggatgctgac ctcagtgggt tactttgctc tgtctctgga tgctcctaat   1260

ttacatggag atgcctacct gaactgtttc ctctctgcct tgattgaaat tccagcttac   1320

attacagcct ggctgctatt gcgaaccctg cccaggcgtt atatcatagc tgcagtactg   1380

ttctggggag gaggtgtgct tctcttcatt caactggtac ctgtggatta ttacttctta   1440

tccattggtc tggtcatgct gggaaaattt gggatcacct ctgctttctc catgctgtat   1500

gtcttcactg ctgagctcta cccaaccctg gtcaggaaca tggcggtggg ggtcacatcc   1560

acggcctcca gagtgggcag catcattgcc ccctactttg tttacctcgg tgcttacaac   1620

agaatgctgc cctacatcgt catgggtagt ctgactgtcc tgattggaat cctcaccctt   1680

tttttccctg aaagtttggg aatgactctt ccagaaacct tagagcagat gcagaaagtg   1740

aaatggttca gatctgggaa aaaaacaaga gactcaatgg agacagaaga aaatcccaag   1800

gttctaataa ctgcattctg aaaaaatatc taccccattt ggtgaagtga aaaacagaaa   1860

aataagaccc tgtggagaaa ttcgttgttc ccactgaaat ggactgactg taacgattga   1920

caccaaaatg aaccttgcta tcaagaaatg ctcgtcatac agtaaactct ggatgattct   1980

tccagataat gtccttgctt tacaaaccaa ccatttctag agagtctcct tactcattaa   2040

ttcaatgaaa tggattggta agatgtcttg aaaacatgtt agtcaaggac tggtaaaata   2100

catataaaga ttaacactca tttccaatca tacaaatact atccaaataa aaataacatc   2160

attgtattaa cgcaaatatt aggtgacaac aaaaaaaaaa aaaaaaaaaa aaaa         2214


<210>  7
<211>  551
<212>  PRT
<213>  Homo sapiens

<220>
<221> 
<223>  Human OCTN1 polypeptide

<400>  7

Met Arg Asp Tyr Asp Glu Val Ile Ala Phe Leu Gly Glu Trp Gly Pro 
1               5                   10                  15      


Phe Gln Arg Leu Ile Phe Phe Leu Leu Ser Ala Ser Ile Ile Pro Asn 
            20                  25                  30          


Gly Phe Asn Gly Met Ser Val Val Phe Leu Ala Gly Thr Pro Glu His 
        35                  40                  45              


Arg Cys Arg Val Pro Asp Ala Ala Asn Leu Ser Ser Ala Trp Arg Asn 
    50                  55                  60                  


Asn Ser Val Pro Leu Arg Leu Arg Asp Gly Arg Glu Val Pro His Ser 
65                  70                  75                  80  


Cys Ser Arg Tyr Arg Leu Ala Thr Ile Ala Asn Phe Ser Ala Leu Gly 
                85                  90                  95      


Leu Glu Pro Gly Arg Asp Val Asp Leu Gly Gln Leu Glu Gln Glu Ser 
            100                 105                 110         


Cys Leu Asp Gly Trp Glu Phe Ser Gln Asp Val Tyr Leu Ser Thr Val 
        115                 120                 125             


Val Thr Glu Trp Asn Leu Val Cys Glu Asp Asn Trp Lys Val Pro Leu 
    130                 135                 140                 


Thr Thr Ser Leu Phe Phe Val Gly Val Leu Leu Gly Ser Phe Val Ser 
145                 150                 155                 160 


Gly Gln Leu Ser Asp Arg Phe Gly Arg Lys Asn Val Leu Phe Ala Thr 
                165                 170                 175     


Met Ala Val Gln Thr Gly Phe Ser Phe Leu Gln Ile Phe Ser Ile Ser 
            180                 185                 190         


Trp Glu Met Phe Thr Val Leu Phe Val Ile Val Gly Met Gly Gln Ile 
        195                 200                 205             


Ser Asn Tyr Val Val Ala Phe Ile Leu Gly Thr Glu Ile Leu Gly Lys 
    210                 215                 220                 


Ser Val Arg Ile Ile Phe Ser Thr Leu Gly Val Cys Thr Phe Phe Ala 
225                 230                 235                 240 


Val Gly Tyr Met Leu Leu Pro Leu Phe Ala Tyr Phe Ile Arg Asp Trp 
                245                 250                 255     


Arg Met Leu Leu Leu Ala Leu Thr Val Pro Gly Val Leu Cys Val Pro 
            260                 265                 270         


Leu Trp Trp Phe Ile Pro Glu Ser Pro Arg Trp Leu Ile Ser Gln Arg 
        275                 280                 285             


Arg Phe Arg Glu Ala Glu Asp Ile Ile Gln Lys Ala Ala Lys Met Asn 
    290                 295                 300                 


Asn Ile Ala Val Pro Ala Val Ile Phe Asp Ser Val Glu Glu Leu Asn 
305                 310                 315                 320 


Pro Leu Lys Gln Gln Lys Ala Phe Ile Leu Asp Leu Phe Arg Thr Arg 
                325                 330                 335     


Asn Ile Ala Ile Met Thr Ile Met Ser Leu Leu Leu Trp Met Leu Thr 
            340                 345                 350         


Ser Val Gly Tyr Phe Ala Leu Ser Leu Asp Ala Pro Asn Leu His Gly 
        355                 360                 365             


Asp Ala Tyr Leu Asn Cys Phe Leu Ser Ala Leu Ile Glu Ile Pro Ala 
    370                 375                 380                 


Tyr Ile Thr Ala Trp Leu Leu Leu Arg Thr Leu Pro Arg Arg Tyr Ile 
385                 390                 395                 400 


Ile Ala Ala Val Leu Phe Trp Gly Gly Gly Val Leu Leu Phe Ile Gln 
                405                 410                 415     


Leu Val Pro Val Asp Tyr Tyr Phe Leu Ser Ile Gly Leu Val Met Leu 
            420                 425                 430         


Gly Lys Phe Gly Ile Thr Ser Ala Phe Ser Met Leu Tyr Val Phe Thr 
        435                 440                 445             


Ala Glu Leu Tyr Pro Thr Leu Val Arg Asn Met Ala Val Gly Val Thr 
    450                 455                 460                 


Ser Thr Ala Ser Arg Val Gly Ser Ile Ile Ala Pro Tyr Phe Val Tyr 
465                 470                 475                 480 


Leu Gly Ala Tyr Asn Arg Met Leu Pro Tyr Ile Val Met Gly Ser Leu 
                485                 490                 495     


Thr Val Leu Ile Gly Ile Leu Thr Leu Phe Phe Pro Glu Ser Leu Gly 
            500                 505                 510         


Met Thr Leu Pro Glu Thr Leu Glu Gln Met Gln Lys Val Lys Trp Phe 
        515                 520                 525             


Arg Ser Gly Lys Lys Thr Arg Asp Ser Met Glu Thr Glu Glu Asn Pro 
    530                 535                 540                 


Lys Val Leu Ile Thr Ala Phe 
545                 550     


<210>  8
<211>  551
<212>  PRT
<213>  Homo sapiens

<220>
<221> 
<223>  Human OCTN1 polypeptide

<400>  8

Met Arg Asp Tyr Asp Glu Val Ile Ala Phe Leu Gly Glu Trp Gly Pro 
1               5                   10                  15      


Phe Gln Arg Leu Ile Phe Phe Leu Leu Ser Ala Ser Ile Ile Pro Asn 
            20                  25                  30          


Gly Phe Asn Gly Met Ser Val Val Phe Leu Ala Gly Thr Pro Glu His 
        35                  40                  45              


Arg Cys Arg Val Pro Asp Ala Ala Asn Leu Ser Ser Ala Trp Arg Asn 
    50                  55                  60                  


Asn Ser Val Pro Leu Arg Leu Arg Asp Gly Arg Glu Val Pro His Ser 
65                  70                  75                  80  


Cys Ser Arg Tyr Arg Leu Ala Thr Ile Ala Asn Phe Ser Ala Leu Gly 
                85                  90                  95      


Leu Glu Pro Gly Arg Asp Val Asp Leu Gly Gln Leu Glu Gln Glu Ser 
            100                 105                 110         


Cys Leu Asp Gly Trp Glu Phe Ser Gln Asp Val Tyr Leu Ser Thr Val 
        115                 120                 125             


Val Thr Glu Trp Asn Leu Val Cys Glu Asp Asn Trp Lys Val Pro Leu 
    130                 135                 140                 


Thr Thr Ser Leu Phe Phe Val Gly Val Leu Leu Gly Ser Phe Val Ser 
145                 150                 155                 160 


Gly Gln Leu Ser Asp Arg Phe Gly Arg Lys Asn Val Leu Phe Ala Thr 
                165                 170                 175     


Met Ala Val Gln Thr Gly Phe Ser Phe Leu Gln Ile Phe Ser Ile Ser 
            180                 185                 190         


Trp Glu Met Phe Thr Val Leu Phe Val Ile Val Gly Met Gly Gln Ile 
        195                 200                 205             


Ser Asn Tyr Val Val Ala Phe Ile Leu Gly Thr Glu Ile Leu Gly Lys 
    210                 215                 220                 


Ser Val Arg Ile Ile Phe Ser Thr Leu Gly Val Cys Thr Phe Phe Ala 
225                 230                 235                 240 


Val Gly Tyr Met Leu Leu Pro Leu Phe Ala Tyr Phe Ile Arg Asp Trp 
                245                 250                 255     


Arg Met Leu Leu Leu Ala Leu Thr Val Pro Gly Val Leu Cys Val Pro 
            260                 265                 270         


Leu Trp Trp Phe Ile Pro Glu Ser Pro Arg Trp Leu Ile Ser Gln Arg 
        275                 280                 285             


Arg Phe Arg Glu Ala Glu Asp Ile Ile Gln Lys Ala Ala Lys Met Asn 
    290                 295                 300                 


Asn Thr Ala Val Pro Ala Val Ile Phe Asp Ser Val Glu Glu Leu Asn 
305                 310                 315                 320 


Pro Leu Lys Gln Gln Lys Ala Phe Ile Leu Asp Leu Phe Arg Thr Arg 
                325                 330                 335     


Asn Ile Ala Ile Met Thr Ile Met Ser Leu Leu Leu Trp Met Leu Thr 
            340                 345                 350         


Ser Val Gly Tyr Phe Ala Leu Ser Leu Asp Ala Pro Asn Leu His Gly 
        355                 360                 365             


Asp Ala Tyr Leu Asn Cys Phe Leu Ser Ala Leu Ile Glu Ile Pro Ala 
    370                 375                 380                 


Tyr Ile Thr Ala Trp Leu Leu Leu Arg Thr Leu Pro Arg Arg Tyr Ile 
385                 390                 395                 400 


Ile Ala Ala Val Leu Phe Trp Gly Gly Gly Val Leu Leu Phe Ile Gln 
                405                 410                 415     


Leu Val Pro Val Asp Tyr Tyr Phe Leu Ser Ile Gly Leu Val Met Leu 
            420                 425                 430         


Gly Lys Phe Gly Ile Thr Ser Ala Phe Ser Met Leu Tyr Val Phe Thr 
        435                 440                 445             


Ala Glu Leu Tyr Pro Thr Leu Val Arg Asn Met Ala Val Gly Val Thr 
    450                 455                 460                 


Ser Thr Ala Ser Arg Val Gly Ser Ile Ile Ala Pro Tyr Phe Val Tyr 
465                 470                 475                 480 


Leu Gly Ala Tyr Asn Arg Met Leu Pro Tyr Ile Val Met Gly Ser Leu 
                485                 490                 495     


Thr Val Leu Ile Gly Ile Phe Thr Leu Phe Phe Pro Glu Ser Leu Gly 
            500                 505                 510         


Met Thr Leu Pro Glu Thr Leu Glu Gln Met Gln Lys Val Lys Trp Phe 
        515                 520                 525             


Arg Ser Gly Lys Lys Thr Arg Asp Ser Met Glu Thr Glu Glu Asn Pro 
    530                 535                 540                 


Lys Val Leu Ile Thr Ala Phe 
545                 550     


<210>  9
<211>  4872
<212>  DNA
<213>  Homo sapiens

<220>
<221> 
<223>  Human MDR-1 polynucleotide

<400>  9
tattcagata ttctccagat tcctaaagat tagagatcat ttctcattct cctaggagta     60

ctcacttcag gaagcaacca gataaaagag aggtgcaacg gaagccagaa cattcctcct    120

ggaaattcaa cctgtttcgc agtttctcga ggaatcagca ttcagtcaat ccgggccggg    180

agcagtcatc tgtggtgagg ctgattggct gggcaggaac agcgccgggg cgtgggctga    240

gcacagccgc ttcgctctct ttgccacagg aagcctgagc tcattcgagt agcggctctt    300

ccaagctcaa agaagcagag gccgctgttc gtttccttta ggtctttcca ctaaagtcgg    360

agtatcttct tccaaaattt cacgtcttgg tggccgttcc aaggagcgcg aggtcggaat    420

ggatcttgaa ggggaccgca atggaggagc aaagaagaag aactttttta aactgaacaa    480

taaaagtgaa aaagataaga aggaaaagaa accaactgtc agtgtatttt caatgtttcg    540

ctattcaaat tggcttgaca agttgtatat ggtggtggga actttggctg ccatcatcca    600

tggggctgga cttcctctca tgatgctggt gtttggagaa atgacagata tctttgcaaa    660

tgcaggaaat ttagaagatc tgatgtcaaa catcactaat agaagtgata tcaatgatac    720

agggttcttc atgaatctgg aggaagacat gaccaggtat gcctattatt acagtggaat    780

tggtgctggg gtgctggttg ctgcttacat tcaggtttca ttttggtgcc tggcagctgg    840

aagacaaata cacaaaatta gaaaacagtt ttttcatgct ataatgcgac aggagatagg    900

ctggtttgat gtgcacgatg ttggggagct taacacccga cttacagatg atgtctccaa    960

gattaatgaa ggaattggtg acaaaattgg aatgttcttt cagtcaatgg caacattttt   1020

cactgggttt atagtaggat ttacacgtgg ttggaagcta acccttgtga ttttggccat   1080

cagtcctgtt cttggactgt cagctgctgt ctgggcaaag atactatctt catttactga   1140

taaagaactc ttagcgtatg caaaagctgg agcagtagct gaagaggtct tggcagcaat   1200

tagaactgtg attgcatttg gaggacaaaa gaaagaactt gaaaggtaca acaaaaattt   1260

agaagaagct aaaagaattg ggataaagaa agctattaca gccaatattt ctataggtgc   1320

tgctttcctg ctgatctatg catcttatgc tctggccttc tggtatggga ccaccttggt   1380

cctctcaggg gaatattcta ttggacaagt actcactgta ttcttttctg tattaattgg   1440

ggcttttagt gttggacagg catctccaag cattgaagca tttgcaaatg caagaggagc   1500

agcttatgaa atcttcaaga taattgataa taagccaagt attgacagct attcgaagag   1560

tgggcacaaa ccagataata ttaagggaaa tttggaattc agaaatgttc acttcagtta   1620

cccatctcga aaagaagtta agatcttgaa gggtctgaac ctgaaggtgc agagtgggca   1680

gacggtggcc ctggttggaa acagtggctg tgggaagagc acaacagtcc agctgatgca   1740

gaggctctat gaccccacag aggggatggt cagtgttgat ggacaggata ttaggaccat   1800

aaatgtaagg tttctacggg aaatcattgg tgtggtgagt caggaacctg tattgtttgc   1860

caccacgata gctgaaaaca ttcgctatgg ccgtgaaaat gtcaccatgg atgagattga   1920

gaaagctgtc aaggaagcca atgcctatga ctttatcatg aaactgcctc ataaatttga   1980

caccctggtt ggagagagag gggcccagtt gagtggtggg cagaagcaga ggatcgccat   2040

tgcacgtgcc ctggttcgca accccaagat cctcctgctg gatgaggcca cgtcagcctt   2100

ggacacagaa agcgaagcag tggttcaggt ggctctggat aaggccagaa aaggtcggac   2160

caccattgtg atagctcatc gtttgtctac agttcgtaat gctgacgtca tcgctggttt   2220

cgatgatgga gtcattgtgg agaaaggaaa tcatgatgaa ctcatgaaag agaaaggcat   2280

ttacttcaaa cttgtcacaa tgcagacagc aggaaatgaa gttgaattag aaaatgcagc   2340

tgatgaatcc aaaagtgaaa ttgatgcctt ggaaatgtct tcaaatgatt caagatccag   2400

tctaataaga aaaagatcaa ctcgtaggag tgtccgtgga tcacaagccc aagacagaaa   2460

gcttagtacc aaagaggctc tggatgaaag tatacctcca gtttcctttt ggaggattat   2520

gaagctaaat ttaactgaat ggccttattt tgttgttggt gtattttgtg ccattataaa   2580

tggaggcctg caaccagcat ttgcaataat attttcaaag attatagggg tttttacaag   2640

aattgatgat cctgaaacaa aacgacagaa tagtaacttg ttttcactat tgtttctagc   2700

ccttggaatt atttctttta ttacattttt ccttcagggt ttcacatttg gcaaagctgg   2760

agagatcctc accaagcggc tccgatacat ggttttccga tccatgctca gacaggatgt   2820

gagttggttt gatgacccta aaaacaccac tggagcattg actaccaggc tcgccaatga   2880

tgctgctcaa gttaaagggg ctataggttc caggcttgct gtaattaccc agaatatagc   2940

aaatcttggg acaggaataa ttatatcctt catctatggt tggcaactaa cactgttact   3000

cttagcaatt gtacccatca ttgcaatagc aggagttgtt gaaatgaaaa tgttgtctgg   3060

acaagcactg aaagataaga aagaactaga aggttctggg aagatcgcta ctgaagcaat   3120

agaaaacttc cgaaccgttg tttctttgac tcaggagcag aagtttgaac atatgtatgc   3180

tcagagtttg caggtaccat acagaaactc tttgaggaaa gcacacatct ttggaattac   3240

attttccttc acccaggcaa tgatgtattt ttcctatgct ggatgtttcc ggtttggagc   3300

ctacttggtg gcacataaac tcatgagctt tgaggatgtt ctgttagtat tttcagctgt   3360

tgtctttggt gccatggccg tggggcaagt cagttcattt gctcctgact atgccaaagc   3420

caaaatatca gcagcccaca tcatcatgat cattgaaaaa acccctttga ttgacagcta   3480

cagcacggaa ggcctaatgc cgaacacatt ggaaggaaat gtcacatttg gtgaagttgt   3540

attcaactat cccacccgac cggacatccc agtgcttcag ggactgagcc tggaggtgaa   3600

gaagggccag acgctggctc tggtgggcag cagtggctgt gggaagagca cagtggtcca   3660

gctcctggag cggttctacg accccttggc agggaaagtg ctgcttgatg gcaaagaaat   3720

aaagcgactg aatgttcagt ggctccgagc acacctgggc atcgtgtccc aggagcccat   3780

cctgtttgac tgcagcattg ctgagaacat tgcctatgga gacaacagcc gggtggtgtc   3840

acaggaagag attgtgaggg cagcaaagga ggccaacata catgccttca tcgagtcact   3900

gcctaataaa tatagcacta aagtaggaga caaaggaact cagctctctg gtggccagaa   3960

acaacgcatt gccatagctc gtgcccttgt tagacagcct catattttgc ttttggatga   4020

agccacgtca gctctggata cagaaagtga aaaggttgtc caagaagccc tggacaaagc   4080

cagagaaggc cgcacctgca ttgtgattgc tcaccgcctg tccaccatcc agaatgcaga   4140

cttaatagtg gtgtttcaga atggcagagt caaggagcat ggcacgcatc agcagctgct   4200

ggcacagaaa ggcatctatt tttcaatggt cagtgtccag gctggaacaa agcgccagtg   4260

aactctgact gtatgagatg ttaaatactt tttaatattt gtttagatat gacatttatt   4320

caaagttaaa agcaaacact tacagaatta tgaagaggta tctgtttaac atttcctcag   4380

tcaagttcag agtcttcaga gacttcgtaa ttaaaggaac agagtgagag acatcatcaa   4440

gtggagagaa atcatagttt aaactgcatt ataaatttta taacagaatt aaagtagatt   4500

ttaaaagata aaatgtgtaa ttttgtttat attttcccat ttggactgta actgactgcc   4560

ttgctaaaag attatagaag tagcaaaaag tattgaaatg tttgcataaa gtgtctataa   4620

taaaactaaa ctttcatgtg actggagtca tcttgtccaa actgcctgtg aatatatctt   4680

ctctcaattg gaatattgta gataacttct gctttaaaaa agttttcttt aaatatacct   4740

actcattttt gtgggaatgg ttaagcagtt taaataattc ctgttgtata tgtctattca   4800

cattgggtct tacagaacca tctggcttca ttcttcttgg acttgatcct gctgattctt   4860

gcatttccac at                                                       4872


<210>  10
<211>  1280
<212>  PRT
<213>  Homo sapiens

<220>
<221> 
<223>  Human MDR-1 polypeptide

<400>  10

Met Asp Leu Glu Gly Asp Arg Asn Gly Gly Ala Lys Lys Lys Asn Phe 
1               5                   10                  15      


Phe Lys Leu Asn Asn Lys Ser Glu Lys Asp Lys Lys Glu Lys Lys Pro 
            20                  25                  30          


Thr Val Ser Val Phe Ser Met Phe Arg Tyr Ser Asn Trp Leu Asp Lys 
        35                  40                  45              


Leu Tyr Met Val Val Gly Thr Leu Ala Ala Ile Ile His Gly Ala Gly 
    50                  55                  60                  


Leu Pro Leu Met Met Leu Val Phe Gly Glu Met Thr Asp Ile Phe Ala 
65                  70                  75                  80  


Asn Ala Gly Asn Leu Glu Asp Leu Met Ser Asn Ile Thr Asn Arg Ser 
                85                  90                  95      


Asp Ile Asn Asp Thr Gly Phe Phe Met Asn Leu Glu Glu Asp Met Thr 
            100                 105                 110         


Arg Tyr Ala Tyr Tyr Tyr Ser Gly Ile Gly Ala Gly Val Leu Val Ala 
        115                 120                 125             


Ala Tyr Ile Gln Val Ser Phe Trp Cys Leu Ala Ala Gly Arg Gln Ile 
    130                 135                 140                 


His Lys Ile Arg Lys Gln Phe Phe His Ala Ile Met Arg Gln Glu Ile 
145                 150                 155                 160 


Gly Trp Phe Asp Val His Asp Val Gly Glu Leu Asn Thr Arg Leu Thr 
                165                 170                 175     


Asp Asp Val Ser Lys Ile Asn Glu Gly Ile Gly Asp Lys Ile Gly Met 
            180                 185                 190         


Phe Phe Gln Ser Met Ala Thr Phe Phe Thr Gly Phe Ile Val Gly Phe 
        195                 200                 205             


Thr Arg Gly Trp Lys Leu Thr Leu Val Ile Leu Ala Ile Ser Pro Val 
    210                 215                 220                 


Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ser Phe Thr 
225                 230                 235                 240 


Asp Lys Glu Leu Leu Ala Tyr Ala Lys Ala Gly Ala Val Ala Glu Glu 
                245                 250                 255     


Val Leu Ala Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln Lys Lys 
            260                 265                 270         


Glu Leu Glu Arg Tyr Asn Lys Asn Leu Glu Glu Ala Lys Arg Ile Gly 
        275                 280                 285             


Ile Lys Lys Ala Ile Thr Ala Asn Ile Ser Ile Gly Ala Ala Phe Leu 
    290                 295                 300                 


Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Thr Thr Leu 
305                 310                 315                 320 


Val Leu Ser Gly Glu Tyr Ser Ile Gly Gln Val Leu Thr Val Phe Phe 
                325                 330                 335     


Ser Val Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ser Pro Ser Ile 
            340                 345                 350         


Glu Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Glu Ile Phe Lys Ile 
        355                 360                 365             


Ile Asp Asn Lys Pro Ser Ile Asp Ser Tyr Ser Lys Ser Gly His Lys 
    370                 375                 380                 


Pro Asp Asn Ile Lys Gly Asn Leu Glu Phe Arg Asn Val His Phe Ser 
385                 390                 395                 400 


Tyr Pro Ser Arg Lys Glu Val Lys Ile Leu Lys Gly Leu Asn Leu Lys 
                405                 410                 415     


Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Asn Ser Gly Cys Gly 
            420                 425                 430         


Lys Ser Thr Thr Val Gln Leu Met Gln Arg Leu Tyr Asp Pro Thr Glu 
        435                 440                 445             


Gly Met Val Ser Val Asp Gly Gln Asp Ile Arg Thr Ile Asn Val Arg 
    450                 455                 460                 


Phe Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val Leu Phe 
465                 470                 475                 480 


Ala Thr Thr Ile Ala Glu Asn Ile Arg Tyr Gly Arg Glu Asn Val Thr 
                485                 490                 495     


Met Asp Glu Ile Glu Lys Ala Val Lys Glu Ala Asn Ala Tyr Asp Phe 
            500                 505                 510         


Ile Met Lys Leu Pro His Lys Phe Asp Thr Leu Val Gly Glu Arg Gly 
        515                 520                 525             


Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala 
    530                 535                 540                 


Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr Ser Ala 
545                 550                 555                 560 


Leu Asp Thr Glu Ser Glu Ala Val Val Gln Val Ala Leu Asp Lys Ala 
                565                 570                 575     


Arg Lys Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser Thr Val 
            580                 585                 590         


Arg Asn Ala Asp Val Ile Ala Gly Phe Asp Asp Gly Val Ile Val Glu 
        595                 600                 605             


Lys Gly Asn His Asp Glu Leu Met Lys Glu Lys Gly Ile Tyr Phe Lys 
    610                 615                 620                 


Leu Val Thr Met Gln Thr Ala Gly Asn Glu Val Glu Leu Glu Asn Ala 
625                 630                 635                 640 


Ala Asp Glu Ser Lys Ser Glu Ile Asp Ala Leu Glu Met Ser Ser Asn 
                645                 650                 655     


Asp Ser Arg Ser Ser Leu Ile Arg Lys Arg Ser Thr Arg Arg Ser Val 
            660                 665                 670         


Arg Gly Ser Gln Ala Gln Asp Arg Lys Leu Ser Thr Lys Glu Ala Leu 
        675                 680                 685             


Asp Glu Ser Ile Pro Pro Val Ser Phe Trp Arg Ile Met Lys Leu Asn 
    690                 695                 700                 


Leu Thr Glu Trp Pro Tyr Phe Val Val Gly Val Phe Cys Ala Ile Ile 
705                 710                 715                 720 


Asn Gly Gly Leu Gln Pro Ala Phe Ala Ile Ile Phe Ser Lys Ile Ile 
                725                 730                 735     


Gly Val Phe Thr Arg Ile Asp Asp Pro Glu Thr Lys Arg Gln Asn Ser 
            740                 745                 750         


Asn Leu Phe Ser Leu Leu Phe Leu Ala Leu Gly Ile Ile Ser Phe Ile 
        755                 760                 765             


Thr Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu 
    770                 775                 780                 


Thr Lys Arg Leu Arg Tyr Met Val Phe Arg Ser Met Leu Arg Gln Asp 
785                 790                 795                 800 


Val Ser Trp Phe Asp Asp Pro Lys Asn Thr Thr Gly Ala Leu Thr Thr 
                805                 810                 815     


Arg Leu Ala Asn Asp Ala Ala Gln Val Lys Gly Ala Ile Gly Ser Arg 
            820                 825                 830         


Leu Ala Val Ile Thr Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile 
        835                 840                 845             


Ile Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Ile 
    850                 855                 860                 


Val Pro Ile Ile Ala Ile Ala Gly Val Val Glu Met Lys Met Leu Ser 
865                 870                 875                 880 


Gly Gln Ala Leu Lys Asp Lys Lys Glu Leu Glu Gly Ser Gly Lys Ile 
                885                 890                 895     


Ala Thr Glu Ala Ile Glu Asn Phe Arg Thr Val Val Ser Leu Thr Gln 
            900                 905                 910         


Glu Gln Lys Phe Glu His Met Tyr Ala Gln Ser Leu Gln Val Pro Tyr 
        915                 920                 925             


Arg Asn Ser Leu Arg Lys Ala His Ile Phe Gly Ile Thr Phe Ser Phe 
    930                 935                 940                 


Thr Gln Ala Met Met Tyr Phe Ser Tyr Ala Gly Cys Phe Arg Phe Gly 
945                 950                 955                 960 


Ala Tyr Leu Val Ala His Lys Leu Met Ser Phe Glu Asp Val Leu Leu 
                965                 970                 975     


Val Phe Ser Ala Val Val Phe Gly Ala Met Ala Val Gly Gln Val Ser 
            980                 985                 990         


Ser Phe Ala Pro Asp Tyr Ala Lys  Ala Lys Ile Ser Ala  Ala His Ile 
        995                 1000                 1005             


Ile Met  Ile Ile Glu Lys Thr  Pro Leu Ile Asp Ser  Tyr Ser Thr 
    1010                 1015                 1020             


Glu Gly  Leu Met Pro Asn Thr  Leu Glu Gly Asn Val  Thr Phe Gly 
    1025                 1030                 1035             


Glu Val  Val Phe Asn Tyr Pro  Thr Arg Pro Asp Ile  Pro Val Leu 
    1040                 1045                 1050             


Gln Gly  Leu Ser Leu Glu Val  Lys Lys Gly Gln Thr  Leu Ala Leu 
    1055                 1060                 1065             


Val Gly  Ser Ser Gly Cys Gly  Lys Ser Thr Val Val  Gln Leu Leu 
    1070                 1075                 1080             


Glu Arg  Phe Tyr Asp Pro Leu  Ala Gly Lys Val Leu  Leu Asp Gly 
    1085                 1090                 1095             


Lys Glu  Ile Lys Arg Leu Asn  Val Gln Trp Leu Arg  Ala His Leu 
    1100                 1105                 1110             


Gly Ile  Val Ser Gln Glu Pro  Ile Leu Phe Asp Cys  Ser Ile Ala 
    1115                 1120                 1125             


Glu Asn  Ile Ala Tyr Gly Asp  Asn Ser Arg Val Val  Ser Gln Glu 
    1130                 1135                 1140             


Glu Ile  Val Arg Ala Ala Lys  Glu Ala Asn Ile His  Ala Phe Ile 
    1145                 1150                 1155             


Glu Ser  Leu Pro Asn Lys Tyr  Ser Thr Lys Val Gly  Asp Lys Gly 
    1160                 1165                 1170             


Thr Gln  Leu Ser Gly Gly Gln  Lys Gln Arg Ile Ala  Ile Ala Arg 
    1175                 1180                 1185             


Ala Leu  Val Arg Gln Pro His  Ile Leu Leu Leu Asp  Glu Ala Thr 
    1190                 1195                 1200             


Ser Ala  Leu Asp Thr Glu Ser  Glu Lys Val Val Gln  Glu Ala Leu 
    1205                 1210                 1215             


Asp Lys  Ala Arg Glu Gly Arg  Thr Cys Ile Val Ile  Ala His Arg 
    1220                 1225                 1230             


Leu Ser  Thr Ile Gln Asn Ala  Asp Leu Ile Val Val  Phe Gln Asn 
    1235                 1240                 1245             


Gly Arg  Val Lys Glu His Gly  Thr His Gln Gln Leu  Leu Ala Gln 
    1250                 1255                 1260             


Lys Gly  Ile Tyr Phe Ser Met  Val Ser Val Gln Ala  Gly Thr Lys 
    1265                 1270                 1275             


Arg Gln  
    1280 


<210>  11
<211>  1280
<212>  PRT
<213>  Homo sapiens

<220>
<221> 
<223>  Human MDR-1 polypeptide

<400>  11

Met Asp Leu Glu Gly Asp Arg Asn Gly Gly Ala Lys Lys Lys Asn Phe 
1               5                   10                  15      


Phe Lys Leu Asn Asn Lys Ser Glu Lys Asp Lys Lys Glu Lys Lys Pro 
            20                  25                  30          


Thr Val Ser Val Phe Ser Met Phe Arg Tyr Ser Asn Trp Leu Asp Lys 
        35                  40                  45              


Leu Tyr Met Val Val Gly Thr Leu Ala Ala Ile Ile His Gly Ala Gly 
    50                  55                  60                  


Leu Pro Leu Met Met Leu Val Phe Gly Glu Met Thr Asp Ile Phe Ala 
65                  70                  75                  80  


Asn Ala Gly Asn Leu Glu Asp Leu Met Ser Asn Ile Thr Asn Arg Ser 
                85                  90                  95      


Asp Ile Asn Asp Thr Gly Phe Phe Met Asn Leu Glu Glu Asp Met Thr 
            100                 105                 110         


Arg Tyr Ala Tyr Tyr Tyr Ser Gly Ile Gly Ala Gly Val Leu Val Ala 
        115                 120                 125             


Ala Tyr Ile Gln Val Ser Phe Trp Cys Leu Ala Ala Gly Arg Gln Ile 
    130                 135                 140                 


His Lys Ile Arg Lys Gln Phe Phe His Ala Ile Met Arg Gln Glu Ile 
145                 150                 155                 160 


Gly Trp Phe Asp Val His Asp Val Gly Glu Leu Asn Thr Arg Leu Thr 
                165                 170                 175     


Asp Asp Val Ser Lys Ile Asn Glu Gly Ile Gly Asp Lys Ile Gly Met 
            180                 185                 190         


Phe Phe Gln Ser Met Ala Thr Phe Phe Thr Gly Phe Ile Val Gly Phe 
        195                 200                 205             


Thr Arg Gly Trp Lys Leu Thr Leu Val Ile Leu Ala Ile Ser Pro Val 
    210                 215                 220                 


Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ser Phe Thr 
225                 230                 235                 240 


Asp Lys Glu Leu Leu Ala Tyr Ala Lys Ala Gly Ala Val Ala Glu Glu 
                245                 250                 255     


Val Leu Ala Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln Lys Lys 
            260                 265                 270         


Glu Leu Glu Arg Tyr Asn Lys Asn Leu Glu Glu Ala Lys Arg Ile Gly 
        275                 280                 285             


Ile Lys Lys Ala Ile Thr Ala Asn Ile Ser Ile Gly Ala Ala Phe Leu 
    290                 295                 300                 


Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Thr Thr Leu 
305                 310                 315                 320 


Val Leu Ser Gly Glu Tyr Ser Ile Gly Gln Val Leu Thr Val Phe Phe 
                325                 330                 335     


Ser Val Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ser Pro Ser Ile 
            340                 345                 350         


Glu Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Glu Ile Phe Lys Ile 
        355                 360                 365             


Ile Asp Asn Lys Pro Ser Ile Asp Ser Tyr Ser Lys Ser Gly His Lys 
    370                 375                 380                 


Pro Asp Asn Ile Lys Gly Asn Leu Glu Phe Arg Asn Val His Phe Ser 
385                 390                 395                 400 


Tyr Pro Ser Arg Lys Glu Val Lys Ile Leu Lys Gly Leu Asn Leu Lys 
                405                 410                 415     


Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Asn Ser Gly Cys Gly 
            420                 425                 430         


Lys Ser Thr Thr Val Gln Leu Met Gln Arg Leu Tyr Asp Pro Thr Glu 
        435                 440                 445             


Gly Met Val Ser Val Asp Gly Gln Asp Ile Arg Thr Ile Asn Val Arg 
    450                 455                 460                 


Phe Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val Leu Phe 
465                 470                 475                 480 


Ala Thr Thr Ile Ala Glu Asn Ile Arg Tyr Gly Arg Glu Asn Val Thr 
                485                 490                 495     


Met Asp Glu Ile Glu Lys Ala Val Lys Glu Ala Asn Ala Tyr Asp Phe 
            500                 505                 510         


Ile Met Lys Leu Pro His Lys Phe Asp Thr Leu Val Gly Glu Arg Gly 
        515                 520                 525             


Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala 
    530                 535                 540                 


Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr Ser Ala 
545                 550                 555                 560 


Leu Asp Thr Glu Ser Glu Ala Val Val Gln Val Ala Leu Asp Lys Ala 
                565                 570                 575     


Arg Lys Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser Thr Val 
            580                 585                 590         


Arg Asn Ala Asp Val Ile Ala Gly Phe Asp Asp Gly Val Ile Val Glu 
        595                 600                 605             


Lys Gly Asn His Asp Glu Leu Met Lys Glu Lys Gly Ile Tyr Phe Lys 
    610                 615                 620                 


Leu Val Thr Met Gln Thr Ala Gly Asn Glu Val Glu Leu Glu Asn Ala 
625                 630                 635                 640 


Ala Asp Glu Ser Lys Ser Glu Ile Asp Ala Leu Glu Met Ser Ser Asn 
                645                 650                 655     


Asp Ser Arg Ser Ser Leu Ile Arg Lys Arg Ser Thr Arg Arg Ser Val 
            660                 665                 670         


Arg Gly Ser Gln Ala Gln Asp Arg Lys Leu Ser Thr Lys Glu Ala Leu 
        675                 680                 685             


Asp Glu Ser Ile Pro Pro Val Ser Phe Trp Arg Ile Met Lys Leu Asn 
    690                 695                 700                 


Leu Thr Glu Trp Pro Tyr Phe Val Val Gly Val Phe Cys Ala Ile Ile 
705                 710                 715                 720 


Asn Gly Gly Leu Gln Pro Ala Phe Ala Ile Ile Phe Ser Lys Ile Ile 
                725                 730                 735     


Gly Val Phe Thr Arg Ile Asp Asp Pro Glu Thr Lys Arg Gln Asn Ser 
            740                 745                 750         


Asn Leu Phe Ser Leu Leu Phe Leu Ala Leu Gly Ile Ile Ser Phe Ile 
        755                 760                 765             


Thr Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu 
    770                 775                 780                 


Thr Lys Arg Leu Arg Tyr Met Val Phe Arg Ser Met Leu Arg Gln Asp 
785                 790                 795                 800 


Val Ser Trp Phe Asp Asp Pro Lys Asn Thr Thr Gly Ala Leu Thr Thr 
                805                 810                 815     


Arg Leu Ala Asn Asp Ala Ala Gln Val Lys Gly Ala Ile Gly Ser Arg 
            820                 825                 830         


Leu Ala Val Ile Thr Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile 
        835                 840                 845             


Ile Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Ile 
    850                 855                 860                 


Val Pro Ile Ile Ala Ile Ala Gly Val Val Glu Met Lys Met Leu Ser 
865                 870                 875                 880 


Gly Gln Ala Leu Lys Asp Lys Lys Glu Leu Glu Gly Ala Gly Lys Ile 
                885                 890                 895     


Ala Thr Glu Ala Ile Glu Asn Phe Arg Thr Val Val Ser Leu Thr Gln 
            900                 905                 910         


Glu Gln Lys Phe Glu His Met Tyr Ala Gln Ser Leu Gln Val Pro Tyr 
        915                 920                 925             


Arg Asn Ser Leu Arg Lys Ala His Ile Phe Gly Ile Thr Phe Ser Phe 
    930                 935                 940                 


Thr Gln Ala Met Met Tyr Phe Ser Tyr Ala Gly Cys Phe Arg Phe Gly 
945                 950                 955                 960 


Ala Tyr Leu Val Ala His Lys Leu Met Ser Phe Glu Asp Val Leu Leu 
                965                 970                 975     


Val Phe Ser Ala Val Val Phe Gly Ala Met Ala Val Gly Gln Val Ser 
            980                 985                 990         


Ser Phe Ala Pro Asp Tyr Ala Lys  Ala Lys Ile Ser Ala  Ala His Ile 
        995                 1000                 1005             


Ile Met  Ile Ile Glu Lys Thr  Pro Leu Ile Asp Ser  Tyr Ser Thr 
    1010                 1015                 1020             


Glu Gly  Leu Met Pro Asn Thr  Leu Glu Gly Asn Val  Thr Phe Gly 
    1025                 1030                 1035             


Glu Val  Val Phe Asn Tyr Pro  Thr Arg Pro Asp Ile  Pro Val Leu 
    1040                 1045                 1050             


Gln Gly  Leu Ser Leu Glu Val  Lys Lys Gly Gln Thr  Leu Ala Leu 
    1055                 1060                 1065             


Val Gly  Ser Ser Gly Cys Gly  Lys Ser Thr Val Val  Gln Leu Leu 
    1070                 1075                 1080             


Glu Arg  Phe Tyr Asp Pro Leu  Ala Gly Lys Val Leu  Leu Asp Gly 
    1085                 1090                 1095             


Lys Glu  Ile Lys Arg Leu Asn  Val Gln Trp Leu Arg  Ala His Leu 
    1100                 1105                 1110             


Gly Ile  Val Ser Gln Glu Pro  Ile Leu Phe Asp Cys  Ser Ile Ala 
    1115                 1120                 1125             


Glu Asn  Ile Ala Tyr Gly Asp  Asn Ser Arg Val Val  Ser Gln Glu 
    1130                 1135                 1140             


Glu Ile  Val Arg Ala Ala Lys  Glu Ala Asn Ile His  Ala Phe Ile 
    1145                 1150                 1155             


Glu Ser  Leu Pro Asn Lys Tyr  Ser Thr Lys Val Gly  Asp Lys Gly 
    1160                 1165                 1170             


Thr Gln  Leu Ser Gly Gly Gln  Lys Gln Arg Ile Ala  Ile Ala Arg 
    1175                 1180                 1185             


Ala Leu  Val Arg Gln Pro His  Ile Leu Leu Leu Asp  Glu Ala Thr 
    1190                 1195                 1200             


Ser Ala  Leu Asp Thr Glu Ser  Glu Lys Val Val Gln  Glu Ala Leu 
    1205                 1210                 1215             


Asp Lys  Ala Arg Glu Gly Arg  Thr Cys Ile Val Ile  Ala His Arg 
    1220                 1225                 1230             


Leu Ser  Thr Ile Gln Asn Ala  Asp Leu Ile Val Val  Phe Gln Asn 
    1235                 1240                 1245             


Gly Arg  Val Lys Glu His Gly  Thr His Gln Gln Leu  Leu Ala Gln 
    1250                 1255                 1260             


Lys Gly  Ile Tyr Phe Ser Met  Val Ser Val Gln Ala  Gly Thr Lys 
    1265                 1270                 1275             


Arg Gln  
    1280 


<210>  12
<211>  48
<212>  PRT
<213>  Lactobacillus plantarum

<220>
<221> 
<223>  Plantaricin A (PlnA)

<220>
<221>  mat_peptide
<222>  (23)..(48)

<400>  12

Met Lys Ile Gln Ile Lys Gly Met Lys Gln Leu Ser Asn Lys Glu Met 
        -20                 -15                 -10             


Gln Lys Ile Val Gly Gly Lys Ser Ser Ala Tyr Ser Leu Gln Met Gly 
    -5              -1  1               5                   10  


Ala Thr Ala Ile Lys Gln Val Lys Lys Leu Phe Lys Lys Trp Gly Trp 
                15                  20                  25      


<210>  13
<211>  212
<212>  PRT
<213>  Neurospora crassa

<220>
<221> 
<223>  Neurospora crassa cPD-1 (Cyclic Phosphodiesterase)

<400>  13

Met Pro Gly Ser Ser Leu Trp Leu Ile Pro Pro Pro Ser His Pro Leu 
1               5                   10                  15      


Tyr Pro Ile Leu Ser Phe Leu Ile Ser Gln His Leu Pro Ser Asp Phe 
            20                  25                  30          


Pro Ser Glu Ala Gly Ala Ala Asp Ala Arg Leu Ile Pro Glu Phe Phe 
        35                  40                  45              


Ala Pro His Met Thr Leu Ser Ser Gly Ile Ser Pro Asp Leu Tyr Gly 
    50                  55                  60                  


Asp Asp Pro Gln Arg Trp Leu Asp Ser Ile Pro Trp Pro Ser Ala Asp 
65                  70                  75                  80  


Glu Val Gln Val Arg Phe Glu Gly Ile Ser Ser Gln Asp Thr Tyr Tyr 
                85                  90                  95      


Arg Arg Cys Tyr Ala Arg Val Lys Leu Asp Glu Gly Ile Lys Lys Ile 
            100                 105                 110         


Ala Gly Leu Ala Arg Ala Arg Gly Val Asn Gly Glu Asp Asp Ala Lys 
        115                 120                 125             


Gly Ala Lys Thr Gln Glu Trp Leu Glu Trp Trp Arg Lys Glu Phe Gly 
    130                 135                 140                 


Pro His Val Ser Leu Met Tyr Gly Asp Val Pro Ile Ser Asp Asp Arg 
145                 150                 155                 160 


Leu Lys Glu Val Ala Lys Val Val Glu Glu Ala Gly Val Lys Leu Ala 
                165                 170                 175     


Glu Pro Glu Gly Asn Val Glu Gly Asn Gly Trp Asn Gly Gly Val Val 
            180                 185                 190         


Trp Leu Val Pro Thr Asp Arg Asp Ile Arg Asp Trp Lys Pro Ile Ala 
        195                 200                 205             


Lys Arg Val Leu 
    210         


<210>  14
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  14
ccatctaagt tgcccgtgaa tcgtt                                           25


<210>  15
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic human OCTN2 sense primer

<400>  15
ttgacccgag tgagttacaa gacc                                            24


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic human OCTN2 anti-sense primer

<400>  16
agcgaaagcc caaaatagcc                                                 20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic murine OCTN2 sense primer

<400>  17
atggattggg gcatctgtcc                                                 20


<210>  18
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic murine OCTN2 anti-sense primer

<400>  18
ggagagggaa aaagacct                                                   18


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic human GAPDH sense primer

<400>  19
tcatctctgc cccctctgct                                                 20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic human GAPDH anti-sense primer

<400>  20
cgacgcctgc ttcaccacct                                                 20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic murine GAPDH sense primer

<400>  21
ggcaaattca agggcacagt                                                 20


<210>  22
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic murine GAPDH anti-sense primer

<400>  22
agatggtgat gggcttccc                                                  19


