<110> Abbott Biotechnology Ltd., et al.

<120> METHODS FOR TREATING JUVENILE IDIOPATHIC ARTHRITIS

<130> BBI-307CPPC

<140> Not Yet Assigned
<141> Concurrently herewith

<150> 60/934310
<151> 2007-06-11

<150> 61/002125
<151> 2007-11-05

<150> 61/066943
<151> 2008-02-25

<160> 37

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> adalimumab light chain variable region

<400> 1
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly

 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         

<210> 2
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> adalimumab heavy chain variable region

<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
    50                  55                  60                  
Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     

<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> adalimumab light chain variable region CDR3

<221> VARIANT        
<222> 9
<223> Xaa = Thr or Ala

<400> 3
Gln Arg Tyr Asn Arg Ala Pro Tyr Xaa
 1               5                  

<210> 4
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> adalimumab heavy chain variable region CDR3

<221> VARIANT        
<222> 12
<223> Xaa = Tyr or Asn

<400> 4
Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Xaa
 1               5                  10          

<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> adalimumab light chain variable region CDR2

<400> 5
Ala Ala Ser Thr Leu Gln Ser
 1               5          

<210> 6
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> adalimumab heavy chain variable region CDR2

<400> 6
Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu
 1               5                  10                  15      
Gly
    
<210> 7
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> adalimumab light chain variable region CDR1

<400> 7
Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala
 1               5                  10      

<210> 8
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> adalimumab heavy chain variable region CDR1

<400> 8
Asp Tyr Ala Met His
 1               5  

<210> 9
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2SD4 light chain variable region

<400> 9
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  

Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Tyr
                85                  90                  95      
Ala Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         

<210> 10
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2SD4 heavy chain variable region

<400> 10
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val
        35                  40                  45              
Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
    50                  55                  60                  
Glu Gly Arg Phe Ala Val Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Lys Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu Asp Asn Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     

<210> 11
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2SD4 light chain variable region CDR3

<400> 11
Gln Lys Tyr Asn Ser Ala Pro Tyr Ala
 1               5                  

<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP B12  light chain variable region CDR3

<400> 12
Gln Lys Tyr Asn Arg Ala Pro Tyr Ala
 1               5                  

<210> 13
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL10E4 light chain variable region CDR3

<400> 13
Gln Lys Tyr Gln Arg Ala Pro Tyr Thr
 1               5                  

<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL100A9 light chain variable region CDR3

<400> 14
Gln Lys Tyr Ser Ser Ala Pro Tyr Thr
 1               5                  

<210> 15
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VLL100D2 light chain variable region CDR3

<400> 15
Gln Lys Tyr Asn Ser Ala Pro Tyr Thr
 1               5                  

<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VLL0F4 light chain variable region CDR3

<400> 16
Gln Lys Tyr Asn Arg Ala Pro Tyr Thr
 1               5                  

<210> 17
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LOE5 light chain variable region CDR3



<400> 17
Gln Lys Tyr Asn Ser Ala Pro Tyr Tyr
 1               5                  

<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VLLOG7 light chain variable region CDR3

<400> 18
Gln Lys Tyr Asn Ser Ala Pro Tyr Asn
 1               5                  

<210> 19
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VLLOG9 light chain variable region CDR3

<400> 19
Gln Lys Tyr Thr Ser Ala Pro Tyr Thr
 1               5                  

<210> 20
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VLLOH1 light chain variable region CDR3

<400> 20
Gln Lys Tyr Asn Arg Ala Pro Tyr Asn
 1               5                  

<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VLLOH10 light chain variable region CDR3

<400> 21
Gln Lys Tyr Asn Ser Ala Ala Tyr Ser
 1               5                  

<210> 22
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL1B7 light chain variable region CDR3

<400> 22
Gln Gln Tyr Asn Ser Ala Pro Asp Thr
 1               5                  

<210> 23
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL1C1 light chain variable region CDR3

<400> 23
Gln Lys Tyr Asn Ser Asp Pro Tyr Thr
 1               5                  

<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL0.1F4 light chain variable region CDR3

<400> 24
Gln Lys Tyr Ile Ser Ala Pro Tyr Thr
 1               5                  

<210> 25
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL0.1H8 light chain variable region CDR3

<400> 25
Gln Lys Tyr Asn Arg Pro Pro Tyr Thr
 1               5                  

<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LOE7.A light chain variable region CDR3

<400> 26
Gln Arg Tyr Asn Arg Ala Pro Tyr Ala
 1               5                  

<210> 27
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2SD4 heavy chain variable region CDR3

<400> 27
Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu Asp Asn
 1               5                  10          

<210> 28
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH1B11 heavy chain variable region CDR3

<400> 28
Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu Asp Lys
 1               5                  10          

<210> 29
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH1D8 heavy chain variable region CDR3

<400> 29
Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu Asp Tyr
 1               5                  10          

<210> 30
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH1A11 heavy chain variable region CDR3

<400> 30
Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu Asp Asp
 1               5                  10          

<210> 31
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH1B12 heavy chain variable region CDR3

<400> 31
Ala Ser Tyr Leu Ser Thr Ser Phe Ser Leu Asp Tyr
 1               5                  10          

<210> 32
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH1E4 heavy chain variable region CDR3

<400> 32
Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu His Tyr
 1               5                  10          

<210> 33
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH1F6 heavy chain variable region CDR3

<400> 33
Ala Ser Phe Leu Ser Thr Ser Ser Ser Leu Glu Tyr
 1               5                  10          

<210> 34
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3C-H2 heavy chain variable region CDR3

<400> 34
Ala Ser Tyr Leu Ser Thr Ala Ser Ser Leu Glu Tyr
 1               5                  10          

<210> 35
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH1-D2.N heavy chain variable region CDR3

<400> 35
Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Asn
 1               5                  10          

<210> 36
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> adalimumab light chain variable region

<400> 36
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtagggga cagagtcacc 60
atcacttgtc gggcaagtca gggcatcaga aattacttag cctggtatca gcaaaaacca 120
gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatct 180
cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctacagcct 240
gaagatgttg caacttatta ctgtcaaagg tataaccgtg caccgtatac ttttggccag 300
gggaccaagg tggaaatcaa a                                           321

<210> 37
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<223> adalimumab heavy chain variable region

<400> 37
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ccggcaggtc cctgagactc 60
tcctgtgcgg cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct 120
ccagggaagg gcctggaatg ggtctcagct atcacttgga atagtggtca catagactat 180
gcggactctg tggagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240
ctgcaaatga acagtctgag agctgaggat acggccgtat attactgtgc gaaagtctcg 300
taccttagca ccgcgtcctc ccttgactat tggggccaag gtaccctggt caccgtctcg 360
agt                                                               363
BBI-307CPPC

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