                         SEQUENCE LISTING

<110>  N.V. Organon
       Carven, Gregory
       Van Eenennaam, Hans
       Dulos, Gradus Johannes
 
<120>  ANTIBODIES TO HPD-1

<130>  OR06827

<150>  60/944583
<151>  2007-06-18

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hPD-1.08A heavy chain variable region

<400>  1
atgrgatgga gctgtatcat kctctttttg gtagcaacag ctacaggtgt ccactcccag       60

gtccaactgc agcagcctgg ggctgaactg gtgaagcctg gggcttcagt gaagttgtcc      120

tgcaaggcct ctggctacac cttcaccagt tattatctgt actggatgaa acagaggcct      180

ggacaaggcc ttgagtggat tgggggggtt aatcctagta atggtggtac taacttcagt      240

gagaagttca agagcaaggc cacactgact gtagacaaat cctccagcac agcctacatg      300

caactcagca gcctgacatc tgaggactct gcggtctatt actgtacaag aagggattct      360

aactacgacg ggggctttga ctactggggc caaggcacta ctctcacagt ctcctcagcc      420

aaaacgacac cccca                                                       435


<210>  2
<211>  453
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hPD-1.08A light chain variable region

<400>  2
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gacattgtgc tgacacagtc tcctacttcc ttagctgtat ctctggggca gagggccacc      120

atctcatgca gggccagcaa aagtgtcagt acatctggct ttagttattt gcactggtac      180

caacagaaac caggacagcc acccaaactc ctcatctttc ttgcatccaa cctagagtct      240

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      300

cctgtggagg aggaggacgc tgcaacctat tattgtcagc acagttggga gcttccgctc      360

acgttcggtg ctgggaccaa gctggagctg aaacgggctg atgctgcacc aactgtatcc      420

atcttcccac catccagtaa gcttgggaag ggc                                   453


<210>  3
<211>  464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hPD-1.09A heavy chain variable region

<400>  3
atgraatgca gctgggttat yctctttttg gtagcaacag ctacaggtgt ccactcccag       60

gtccaactgc agcagcctgg ggctgaactg gtgaagcctg ggacttcagt gaagttgtcc      120

tgcaaggctt ctggctacac cttcaccaac tactatatgt actgggtgaa gcagaggcct      180

ggacaaggcc ttgagtggat tggggggatt aatcctagca atggtggtac taacttcaat      240

gagaagttca agaacaaggc cacactgact gtagacagtt cctccagcac aacctacatg      300

caactcagca gcctgacatc tgaggactct gcggtctatt actgtacaag aagggattat      360

aggttcgaca tgggctttga ctactggggc caaggcacca ctctcacagt ctcctcagcc      420

aaaacgacac ccccatccgt ytatcccbtg gcccctggaa gctt                       464


<210>  4
<211>  438
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hPD-1.09A light chain variable region

<400>  4
atggagwcag acacactsct gytatgggta ctgctgctct gggttccagg ttccactggc       60

gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctgggaca gagggccgcc      120

atctcatgca gggccagcaa aggtgtcagt acatctggct atagttattt gcactggtac      180

caacagaaac caggacagtc acccaaactc ctcatctatc ttgcatccta cctagaatct      240

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      300

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga ccttccgctc      360

acgttcggta ctgggaccaa gctggagctg aaacgggctg atgctgcacc aactgtatcc      420

atcttcccac catccagt                                                    438


<210>  5
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPD-1.08A heavy chain variable region

<400>  5

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu Tyr Trp Met Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Val Asn Pro Ser Asn Gly Gly Thr Asn Phe Ser Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Asp Ser Asn Tyr Asp Gly Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Lys 
        115                 120         


<210>  6
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPD-1.08A light chain variable region

<400>  6

Asp Ile Val Leu Thr Gln Ser Pro Thr Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Phe Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  7
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPD-1.09A heavy chain variable region

<400>  7

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Ser Ser Ser Ser Thr Thr Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Lys 
        115                 120         


<210>  8
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPD-1.09A light chain variable region

<400>  8

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Ala Ile Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPD-1.08A light chain CDR1

<400>  9

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Phe Ser Tyr Leu His 
1               5                   10                  15  


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPD-1.08A light chain CDR2

<400>  10

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPD-1-08A light chain CDR3

<400>  11

Gln His Ser Trp Glu Leu Pro Leu Thr 
1               5                   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPD-1.08A heavy chain CDR1

<400>  12

Ser Tyr Tyr Leu Tyr 
1               5   


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPD-1.08A heavy chain CDR2

<400>  13

Gly Val Asn Pro Ser Asn Gly Gly Thr Asn Phe Ser Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPD-1.08A heavy chain CDR3

<400>  14

Arg Asp Ser Asn Tyr Asp Gly Gly Phe Asp Tyr 
1               5                   10      


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPD-1.09A light chain CDR1

<400>  15

Arg Ala Ser Lys Gly Val Ser Thr Ser Gly Tyr Ser Tyr Leu His 
1               5                   10                  15  


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPD-1.09A light chain CDR2

<400>  16

Leu Ala Ser Tyr Leu Glu Ser 
1               5           


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPD-1.09A light chain CDR3

<400>  17

Gln His Ser Arg Asp Leu Pro Leu Thr 
1               5                   


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPD-1.09A heavy chain CDR1

<400>  18

Asn Tyr Tyr Met Tyr 
1               5   


<210>  19
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPD-1.09A heavy chain CDR2

<400>  19

Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPD-1.09A heavy chain CDR3

<400>  20

Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr 
1               5                   10      


<210>  21
<211>  417
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  109A-H heavy chain variable region


<220>
<221>  sig_peptide
<222>  (1)..(57)

<400>  21
atggactgga cctggagcat ccttttcttg gtggcagcac caacaggagc ccactcccaa       60

gtgcagctgg tgcagtctgg agttgaagtg aagaagcccg gggcctcagt gaaggtctcc      120

tgcaaggctt ctggctacac ctttaccaac tactatatgt actgggtgcg acaggcccct      180

ggacaagggc ttgagtggat gggagggatt aatcctagca atggtggtac taacttcaat      240

gagaagttca agaacagagt caccttgacc acagactcat ccacgaccac agcctacatg      300

gaactgaaga gcctgcaatt tgacgacacg gccgtttatt actgtgcgag aagggattat      360

aggttcgaca tgggctttga ctactggggc caagggacca cggtcaccgt ctcgagc         417


<210>  22
<211>  417
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized 109A-H heavy chain variable region


<220>
<221>  sig_peptide
<222>  (1)..(57)

<400>  22
atggactgga cctggtctat cctgttcctg gtggccgctc ctaccggcgc tcactcccag       60

gtgcagctgg tgcagtccgg cgtggaggtg aagaagcctg gcgcctccgt caaggtgtcc      120

tgcaaggcct ccggctacac cttcaccaac tactacatgt actgggtgcg gcaggctccc      180

ggccagggac tggagtggat gggcggcatc aacccttcca acggcggcac caacttcaac      240

gagaagttca agaaccgggt gaccctgacc accgactcct ccaccaccac cgcctacatg      300

gagctgaagt ccctgcagtt cgacgacacc gccgtgtact actgcgccag gcgggactac      360

cggttcgaca tgggcttcga ctactggggc cagggcacca ccgtgaccgt gtcctcc         417


<210>  23
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized 409A-H heavy chain full length


<220>
<221>  sig_peptide
<222>  (1)..(57)

<400>  23
atggccgtgc tgggcctgct gttctgcctg gtgaccttcc cttcctgcgt gctgtcccag       60

gtgcagctgg tgcagtccgg cgtggaggtg aagaagcctg gcgcctccgt caaggtgtcc      120

tgtaaggcct ccggctacac cttcaccaac tactacatgt actgggtgcg gcaggcccca      180

ggccagggac tggagtggat gggcggcatc aacccttcca acggcggcac caacttcaac      240

gagaagttca agaaccgggt gaccctgacc accgactcct ccaccacaac cgcctacatg      300

gaactgaagt ccctgcagtt cgacgacacc gccgtgtact actgcgccag gcgggactac      360

cggttcgaca tgggcttcga ctactggggc cagggcacca ccgtgaccgt gtcctccgct      420

agcaccaagg gcccttccgt gttccctctg gccccttgct cccggtccac ctccgagtcc      480

accgccgctc tgggctgtct ggtgaaggac tacttccctg agcctgtgac cgtgagctgg      540

aactctggcg ccctgacctc cggcgtgcac accttccctg ccgtgctgca gtcctccggc      600

ctgtactccc tgtcctccgt ggtgaccgtg ccttcctcct ccctgggcac caagacctac      660

acctgcaacg tggaccacaa gccttccaac accaaggtgg acaagcgggt ggagtccaag      720

tacggccctc cttgccctcc ctgccctgcc cctgagttcc tgggcggacc ctccgtgttc      780

ctgttccctc ctaagcctaa ggacaccctg atgatctccc ggacccctga ggtgacctgc      840

gtggtggtgg acgtgtccca ggaagatcct gaggtccagt tcaattggta cgtggatggc      900

gtggaggtgc acaacgccaa gaccaagcct cgggaggaac agttcaactc cacctaccgg      960

gtggtgtctg tgctgaccgt gctgcaccag gactggctga acggcaagga atacaagtgc     1020

aaggtcagca acaagggcct gccctcctcc atcgagaaaa ccatctccaa ggccaagggc     1080

cagcctcgcg agcctcaggt gtacaccctg cctcctagcc aggaagagat gaccaagaat     1140

caggtgtccc tgacatgcct ggtgaagggc ttctaccctt ccgatatcgc cgtggagtgg     1200

gagagcaacg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactccgac     1260

ggctccttct tcctgtactc caggctgacc gtggacaagt cccggtggca ggaaggcaac     1320

gtcttttcct gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg     1380

tccctgtctc tgggcaag                                                   1398


<210>  24
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  K09A-L-11 light chain variable region


<220>
<221>  sig_peptide
<222>  (1)..(60)

<400>  24
atggaagccc cagctcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagcaa aggtgtcagt acatctggct atagttattt gcactggtat      180

caacagaaac ctggccaggc tcccaggctc ctcatctatc ttgcatccta cctagaatct      240

ggcgtcccag ccaggttcag tggtagtggg tctgggacag acttcactct caccatcagc      300

agcctagagc ctgaagattt tgcagtttat tactgtcagc acagcaggga ccttccgctc      360

acgttcggcg gagggaccaa agtggagatc aaa                                   393


<210>  25
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  K09A-L-16 light chain variable region


<220>
<221>  sig_peptide
<222>  (1)..(60)

<400>  25
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgc tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc      120

atctcctgca gggccagcaa aggtgtcagt acatctggct atagttattt gcattggtac      180

ctccagaagc cagggcagtc tccacagctc ctgatctatc ttgcatccta cctagaatct      240

ggggtccctg acaggttcag tggcagtgga tcaggcacag attttacact gaaaatcagc      300

agagtggagg ctgaggatgt tggggtttat tactgccagc atagtaggga ccttccgctc      360

acgtttggcc aggggaccaa gctggagatc aaa                                   393


<210>  26
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  K09A-L-17 light chain variable region


<220>
<221>  sig_peptide
<222>  (1)..(60)

<400>  26
atgaggctcc ctgctcagct cctggggctg ctaatgctct gggtctctgg atccagtggg       60

gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc      120

atctcctgca gggccagcaa aggtgtcagt acatctggct atagttattt gcattggtat      180

ctgcagaagc cagggcagtc tccacagctc ctgatctatc ttgcatccta cctagaatct      240

ggagtcccag acaggttcag tggcagtggg tcaggcactg ctttcacact gaaaatcagc      300

agggtggagg ctgaggatgt tggactttat tactgccagc atagtaggga ccttccgctc      360

acgtttggcc aggggaccaa gctggagatc aaa                                   393


<210>  27
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized K09A-L-11 light chain variable region


<220>
<221>  sig_peptide
<222>  (1)..(57)

<400>  27
atggcccctg tgcagctgct gggcctgctg gtgctgttcc tgcctgccat gcggtgcgag       60

atcgtgctga cccagtcccc tgccaccctg tccctgagcc ctggcgagcg ggctaccctg      120

agctgcagag cctccaaggg cgtgtccacc tccggctact cctacctgca ctggtatcag      180

cagaagccag gccaggcccc tcggctgctg atctacctgg cctcctacct ggagtccggc      240

gtgcctgccc ggttctccgg ctccggaagc ggcaccgact tcaccctgac catctcctcc      300

ctggagcctg aggacttcgc cgtgtactac tgccagcact cccgggacct gcctctgacc      360

tttggcggcg gaacaaaggt ggagatcaag                                       390


<210>  28
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized K09A-L-16 light chain variable region


<220>
<221>  sig_peptide
<222>  (1)..(57)

<400>  28
atggcccctg tgcagctgct gggcctgctg gtgctgttcc tgcctgccat gcggtgcgag       60

atcgtgctga cccagtcccc tctgtccctg cctgtgaccc ctggcgagcc tgcctccatc      120

tcctgccggg cctccaaggg cgtgtccacc tccggctact cctacctgca ctggtatctg      180

cagaagcctg gccagtcccc ccagctgctg atctacctgg cctcctacct ggagtccggc      240

gtgcctgacc ggttctccgg ctccggcagc ggcaccgact tcaccctgaa gatctcccgg      300

gtggaggccg aggacgtggg cgtgtactac tgccagcact cccgggacct gcctctgacc      360

ttcggccagg gcaccaagct ggagatcaag                                       390


<210>  29
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized K09A-L-17 light chain variable region


<220>
<221>  sig_peptide
<222>  (1)..(57)

<400>  29
atggcccctg tgcagctgct gggcctgctg gtgctgttcc tgcctgccat gcggtgcgac       60

atcgtgatga cccagacccc tctgtccctg cctgtgaccc ctggcgagcc tgcctccatc      120

tcctgccggg cctccaaggg cgtgtccacc tccggctact cctacctgca ctggtatctg      180

cagaagcctg gccagtcccc tcagctgctg atctacctgg cctcctacct ggagtccggc      240

gtgcctgacc ggttctccgg ctccggaagc ggcaccgctt ttaccctgaa gatctccaga      300

gtggaggccg aggacgtggg cctgtactac tgccagcact cccgggacct gcctctgacc      360

ttcggccagg gcaccaagct ggagatcaag                                       390


<210>  30
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  109A-H heavy chain variable region


<220>
<221>  sig_peptide
<222>  (1)..(19)

<400>  30

Met Asp Trp Thr Trp Ser Ile Leu Phe Leu Val Ala Ala Pro Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 


<210>  31
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  409A-H heavy chain full length


<220>
<221>  sig_peptide
<222>  (1)..(19)

<400>  31

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
    210                 215                 220                 


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
225                 230                 235                 240 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    450                 455                 460                 


Gly Lys 
465     


<210>  32
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K09A-L-11 light chain variable region


<220>
<221>  sig_peptide
<222>  (1)..(19)

<400>  32

Met Ala Pro Val Gln Leu Leu Gly Leu Leu Val Leu Phe Leu Pro Ala 
1               5                   10                  15      


Met Arg Cys Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val 
        35                  40                  45              


Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys 
    130 


<210>  33
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K09A-L-16 light chain variable region


<220>
<221>  sig_peptide
<222>  (1)..(19)

<400>  33

Met Ala Pro Val Gln Leu Leu Gly Leu Leu Val Leu Phe Leu Pro Ala 
1               5                   10                  15      


Met Arg Cys Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Gly Val 
        35                  40                  45              


Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ser Pro Gln Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Asp Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys 
    130 


<210>  34
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K09A-L-17 light chain variable region


<220>
<221>  sig_peptide
<222>  (1)..(19)

<400>  34

Met Ala Pro Val Gln Leu Leu Gly Leu Leu Val Leu Phe Leu Pro Ala 
1               5                   10                  15      


Met Arg Cys Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Gly Val 
        35                  40                  45              


Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ser Pro Gln Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu 
                85                  90                  95      


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Asp Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys 
    130 


<210>  35
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  109A-H heavy chain full length


<220>
<221>  sig_peptide
<222>  (1)..(19)

<400>  35

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  36
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K09A-L-11 light chain full length


<220>
<221>  sig_peptide
<222>  (1)..(19)

<400>  36

Met Ala Pro Val Gln Leu Leu Gly Leu Leu Val Leu Phe Leu Pro Ala 
1               5                   10                  15      


Met Arg Cys Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val 
        35                  40                  45              


Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  37
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K09A-L-16 light chain full length


<220>
<221>  sig_peptide
<222>  (1)..(19)

<400>  37

Met Ala Pro Val Gln Leu Leu Gly Leu Leu Val Leu Phe Leu Pro Ala 
1               5                   10                  15      


Met Arg Cys Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Gly Val 
        35                  40                  45              


Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ser Pro Gln Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Asp Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  38
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K09A-L-17 light chain full length


<220>
<221>  sig_peptide
<222>  (1)..(19)

<400>  38

Met Ala Pro Val Gln Leu Leu Gly Leu Leu Val Leu Phe Leu Pro Ala 
1               5                   10                  15      


Met Arg Cys Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Gly Val 
        35                  40                  45              


Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ser Pro Gln Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu 
                85                  90                  95      


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Asp Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


