                              Sequence Listing

<110> GENENTECH, INC.
      Behrens, Timothy W.
      Townsend, Michael J.

<120> Biological Markers Predictive of Rheumatoid Arthritis 
      Response to B-cell Antagonists

<130> P2446R1 WO

<141> 2008-06-13

<150> US 60/944,713
<151> 2007-06-18

<160> 25

<210> 1
<211> 107
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 1
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser
                  20                  25                  30

 Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro
                  35                  40                  45

 Leu Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ser Arg
                  50                  55                  60

 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                  65                  70                  75

 Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp
                  80                  85                  90

 Ser Phe Asn Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
                  95                 100                 105

 Lys Arg
        

<210> 2
<211> 122
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 2
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr
                  50                  55                  60

 Asn Gln Lys Phe Lys Gly Arg Phe Thr Ile Ser Val Asp Lys Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser
                  95                 100                 105

 Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val
                 110                 115                 120

 Ser Ser
        

<210> 3
<211> 107
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 3
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser
                  20                  25                  30

 Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro
                  35                  40                  45

 Leu Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ser Arg
                  50                  55                  60

 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                  65                  70                  75

 Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp
                  80                  85                  90

 Ala Phe Asn Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
                  95                 100                 105

 Lys Arg
        

<210> 4
<211> 122
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 4
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Ala Ile Tyr Pro Gly Asn Gly Ala Thr Ser Tyr
                  50                  55                  60

 Asn Gln Lys Phe Lys Gly Arg Phe Thr Ile Ser Val Asp Lys Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr Tyr Ser Ala Ser
                  95                 100                 105

 Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val
                 110                 115                 120

 Ser Ser
        

<210> 5
<211> 122
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 5
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Ala Ile Tyr Pro Gly Asn Gly Ala Thr Ser Tyr
                  50                  55                  60

 Asn Gln Lys Phe Lys Gly Arg Phe Thr Ile Ser Val Asp Lys Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr Tyr Ser Tyr Arg
                  95                 100                 105

 Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val
                 110                 115                 120

 Ser Ser
        

<210> 6
<211> 213
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 6
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser
                  20                  25                  30

 Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro
                  35                  40                  45

 Leu Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ser Arg
                  50                  55                  60

 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                  65                  70                  75

 Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp
                  80                  85                  90

 Ser Phe Asn Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
                  95                 100                 105

 Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
                 110                 115                 120

 Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
                 125                 130                 135

 Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp
                 140                 145                 150

 Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln
                 155                 160                 165

 Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu
                 170                 175                 180

 Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val
                 185                 190                 195

 Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg
                 200                 205                 210

 Gly Glu Cys
            

<210> 7
<211> 452
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 7
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr
                  50                  55                  60

 Asn Gln Lys Phe Lys Gly Arg Phe Thr Ile Ser Val Asp Lys Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser
                  95                 100                 105

 Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val
                 110                 115                 120

 Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
                 125                 130                 135

 Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
                 140                 145                 150

 Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
                 155                 160                 165

 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                 170                 175                 180

 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
                 185                 190                 195

 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
                 200                 205                 210

 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
                 215                 220                 225

 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
                 230                 235                 240

 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                 245                 250                 255

 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                 260                 265                 270

 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
                 275                 280                 285

 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
                 290                 295                 300

 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                 305                 310                 315

 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                 320                 325                 330

 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
                 335                 340                 345

 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
                 350                 355                 360

 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
                 365                 370                 375

 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
                 380                 385                 390

 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
                 395                 400                 405

 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                 410                 415                 420

 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
                 425                 430                 435

 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
                 440                 445                 450

 Gly Lys
        

<210> 8
<211> 452
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 8
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr
                  50                  55                  60

 Asn Gln Lys Phe Lys Gly Arg Phe Thr Ile Ser Val Asp Lys Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser
                  95                 100                 105

 Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val
                 110                 115                 120

 Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
                 125                 130                 135

 Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
                 140                 145                 150

 Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
                 155                 160                 165

 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                 170                 175                 180

 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
                 185                 190                 195

 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
                 200                 205                 210

 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
                 215                 220                 225

 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
                 230                 235                 240

 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                 245                 250                 255

 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                 260                 265                 270

 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
                 275                 280                 285

 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
                 290                 295                 300

 Tyr Asn Ala Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                 305                 310                 315

 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                 320                 325                 330

 Lys Ala Leu Pro Ala Pro Ile Ala Ala Thr Ile Ser Lys Ala Lys
                 335                 340                 345

 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
                 350                 355                 360

 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
                 365                 370                 375

 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
                 380                 385                 390

 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
                 395                 400                 405

 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                 410                 415                 420

 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
                 425                 430                 435

 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
                 440                 445                 450

 Gly Lys
        

<210> 9
<211> 213
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 9
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser
                  20                  25                  30

 Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro
                  35                  40                  45

 Leu Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ser Arg
                  50                  55                  60

 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                  65                  70                  75

 Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp
                  80                  85                  90

 Ala Phe Asn Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
                  95                 100                 105

 Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
                 110                 115                 120

 Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
                 125                 130                 135

 Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp
                 140                 145                 150

 Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln
                 155                 160                 165

 Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu
                 170                 175                 180

 Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val
                 185                 190                 195

 Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg
                 200                 205                 210

 Gly Glu Cys
            

<210> 10
<211> 452
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 10
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Ala Ile Tyr Pro Gly Asn Gly Ala Thr Ser Tyr
                  50                  55                  60

 Asn Gln Lys Phe Lys Gly Arg Phe Thr Ile Ser Val Asp Lys Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr Tyr Ser Ala Ser
                  95                 100                 105

 Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val
                 110                 115                 120

 Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
                 125                 130                 135

 Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
                 140                 145                 150

 Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
                 155                 160                 165

 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                 170                 175                 180

 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
                 185                 190                 195

 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
                 200                 205                 210

 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
                 215                 220                 225

 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
                 230                 235                 240

 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                 245                 250                 255

 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                 260                 265                 270

 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
                 275                 280                 285

 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
                 290                 295                 300

 Tyr Asn Ala Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                 305                 310                 315

 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                 320                 325                 330

 Lys Ala Leu Pro Ala Pro Ile Ala Ala Thr Ile Ser Lys Ala Lys
                 335                 340                 345

 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
                 350                 355                 360

 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
                 365                 370                 375

 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
                 380                 385                 390

 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
                 395                 400                 405

 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                 410                 415                 420

 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
                 425                 430                 435

 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
                 440                 445                 450

 Gly Lys
        

<210> 11
<211> 452
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 11
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Ala Ile Tyr Pro Gly Asn Gly Ala Thr Ser Tyr
                  50                  55                  60

 Asn Gln Lys Phe Lys Gly Arg Phe Thr Ile Ser Val Asp Lys Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr Tyr Ser Ala Ser
                  95                 100                 105

 Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val
                 110                 115                 120

 Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
                 125                 130                 135

 Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
                 140                 145                 150

 Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
                 155                 160                 165

 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                 170                 175                 180

 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
                 185                 190                 195

 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
                 200                 205                 210

 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
                 215                 220                 225

 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
                 230                 235                 240

 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                 245                 250                 255

 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                 260                 265                 270

 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
                 275                 280                 285

 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
                 290                 295                 300

 Tyr Asn Ala Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                 305                 310                 315

 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn
                 320                 325                 330

 Lys Ala Leu Pro Ala Pro Ile Glu Ala Thr Ile Ser Lys Ala Lys
                 335                 340                 345

 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
                 350                 355                 360

 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
                 365                 370                 375

 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
                 380                 385                 390

 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
                 395                 400                 405

 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                 410                 415                 420

 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
                 425                 430                 435

 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
                 440                 445                 450

 Gly Lys
        

<210> 12
<211> 452
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 12
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Ala Ile Tyr Pro Gly Asn Gly Ala Thr Ser Tyr
                  50                  55                  60

 Asn Gln Lys Phe Lys Gly Arg Phe Thr Ile Ser Val Asp Lys Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr Tyr Ser Ala Ser
                  95                 100                 105

 Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val
                 110                 115                 120

 Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
                 125                 130                 135

 Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
                 140                 145                 150

 Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
                 155                 160                 165

 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                 170                 175                 180

 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
                 185                 190                 195

 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
                 200                 205                 210

 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
                 215                 220                 225

 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
                 230                 235                 240

 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                 245                 250                 255

 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                 260                 265                 270

 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
                 275                 280                 285

 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
                 290                 295                 300

 Tyr Asn Ala Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                 305                 310                 315

 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                 320                 325                 330

 Ala Ala Leu Pro Ala Pro Ile Ala Ala Thr Ile Ser Lys Ala Lys
                 335                 340                 345

 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
                 350                 355                 360

 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
                 365                 370                 375

 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
                 380                 385                 390

 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
                 395                 400                 405

 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                 410                 415                 420

 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
                 425                 430                 435

 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
                 440                 445                 450

 Gly Lys
        

<210> 13
<211> 452
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 13
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Ala Ile Tyr Pro Gly Asn Gly Ala Thr Ser Tyr
                  50                  55                  60

 Asn Gln Lys Phe Lys Gly Arg Phe Thr Ile Ser Val Asp Lys Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr Tyr Ser Ala Ser
                  95                 100                 105

 Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val
                 110                 115                 120

 Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
                 125                 130                 135

 Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
                 140                 145                 150

 Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
                 155                 160                 165

 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                 170                 175                 180

 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
                 185                 190                 195

 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
                 200                 205                 210

 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
                 215                 220                 225

 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
                 230                 235                 240

 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                 245                 250                 255

 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                 260                 265                 270

 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
                 275                 280                 285

 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
                 290                 295                 300

 Tyr Asn Ala Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                 305                 310                 315

 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                 320                 325                 330

 Ala Ala Leu Pro Ala Pro Ile Ala Ala Thr Ile Ser Lys Ala Lys
                 335                 340                 345

 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
                 350                 355                 360

 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
                 365                 370                 375

 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
                 380                 385                 390

 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
                 395                 400                 405

 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                 410                 415                 420

 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
                 425                 430                 435

 Ala Leu His Trp His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
                 440                 445                 450

 Gly Lys
        

<210> 14
<211> 452
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 14
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Ala Ile Tyr Pro Gly Asn Gly Ala Thr Ser Tyr
                  50                  55                  60

 Asn Gln Lys Phe Lys Gly Arg Phe Thr Ile Ser Val Asp Lys Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr Tyr Ser Tyr Arg
                  95                 100                 105

 Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val
                 110                 115                 120

 Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
                 125                 130                 135

 Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
                 140                 145                 150

 Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
                 155                 160                 165

 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                 170                 175                 180

 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
                 185                 190                 195

 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
                 200                 205                 210

 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
                 215                 220                 225

 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
                 230                 235                 240

 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                 245                 250                 255

 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                 260                 265                 270

 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
                 275                 280                 285

 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
                 290                 295                 300

 Tyr Asn Ala Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                 305                 310                 315

 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                 320                 325                 330

 Ala Ala Leu Pro Ala Pro Ile Ala Ala Thr Ile Ser Lys Ala Lys
                 335                 340                 345

 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
                 350                 355                 360

 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
                 365                 370                 375

 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
                 380                 385                 390

 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
                 395                 400                 405

 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                 410                 415                 420

 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
                 425                 430                 435

 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
                 440                 445                 450

 Gly Lys
        

<210> 15
<211> 452
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 15
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr
                  50                  55                  60

 Asn Gln Lys Phe Lys Gly Arg Phe Thr Ile Ser Val Asp Lys Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser
                  95                 100                 105

 Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val
                 110                 115                 120

 Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
                 125                 130                 135

 Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
                 140                 145                 150

 Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
                 155                 160                 165

 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                 170                 175                 180

 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
                 185                 190                 195

 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
                 200                 205                 210

 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
                 215                 220                 225

 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
                 230                 235                 240

 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                 245                 250                 255

 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                 260                 265                 270

 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
                 275                 280                 285

 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
                 290                 295                 300

 Tyr Asn Ala Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                 305                 310                 315

 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                 320                 325                 330

 Ala Ala Leu Pro Ala Pro Ile Ala Ala Thr Ile Ser Lys Ala Lys
                 335                 340                 345

 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
                 350                 355                 360

 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
                 365                 370                 375

 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
                 380                 385                 390

 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
                 395                 400                 405

 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                 410                 415                 420

 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
                 425                 430                 435

 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
                 440                 445                 450

 Gly Lys
        

<210> 16
<211> 499
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 16
 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala
   1               5                  10                  15

 Ser Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro
                  20                  25                  30

 Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys
                  35                  40                  45

 Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys
                  50                  55                  60

 Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu
                  65                  70                  75

 Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr
                  80                  85                  90

 Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala
                  95                 100                 105

 Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly
                 110                 115                 120

 Ala Gly Thr Lys Leu Glu Leu Lys Asp Gly Gly Gly Ser Gly Gly
                 125                 130                 135

 Gly Gly Ser Gly Gly Gly Gly Ser Ser Gln Ala Tyr Leu Gln Gln
                 140                 145                 150

 Ser Gly Ala Glu Ser Val Arg Pro Gly Ala Ser Val Lys Met Ser
                 155                 160                 165

 Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp
                 170                 175                 180

 Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala Ile
                 185                 190                 195

 Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly
                 200                 205                 210

 Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met
                 215                 220                 225

 Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 230                 235                 240

 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val
                 245                 250                 255

 Trp Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys
                 260                 265                 270

 Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser Ala Pro Glu
                 275                 280                 285

 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                 290                 295                 300

 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
                 305                 310                 315

 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
                 320                 325                 330

 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                 335                 340                 345

 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
                 350                 355                 360

 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
                 365                 370                 375

 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
                 380                 385                 390

 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
                 395                 400                 405

 Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
                 410                 415                 420

 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
                 425                 430                 435

 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
                 440                 445                 450

 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
                 455                 460                 465

 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                 470                 475                 480

 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
                 485                 490                 495

 Ser Pro Gly Lys
                

<210> 17
<211> 106
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 17
 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro
   1               5                  10                  15

 Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Pro
                  20                  25                  30

 Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu
                  35                  40                  45

 Leu Ile Tyr Ala Thr Ser Ala Leu Ala Ser Gly Ile Pro Asp Arg
                  50                  55                  60

 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                  65                  70                  75

 Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp
                  80                  85                  90

 Leu Ser Asn Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
                  95                 100                 105

 Lys
    

<210> 18
<211> 121
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 18
 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Arg Thr Phe Thr
                  20                  25                  30

 Ser Tyr Asn Met His Trp Val Arg Gln Met Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Met Gly Ala Ile Tyr Pro Leu Thr Gly Asp Thr Ser Tyr
                  50                  55                  60

 Asn Gln Lys Ser Lys Leu Gln Val Thr Ile Ser Ala Asp Lys Ser
                  65                  70                  75

 Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp
                  80                  85                  90

 Thr Ala Met Tyr Tyr Cys Ala Arg Ser Thr Tyr Val Gly Gly Asp
                  95                 100                 105

 Trp Gln Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser
                 110                 115                 120

 Ser
    

<210> 19
<211> 213
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 19
 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro
   1               5                  10                  15

 Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Pro
                  20                  25                  30

 Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu
                  35                  40                  45

 Leu Ile Tyr Ala Thr Ser Ala Leu Ala Ser Gly Ile Pro Asp Arg
                  50                  55                  60

 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                  65                  70                  75

 Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp
                  80                  85                  90

 Leu Ser Asn Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
                  95                 100                 105

 Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
                 110                 115                 120

 Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
                 125                 130                 135

 Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp
                 140                 145                 150

 Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln
                 155                 160                 165

 Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu
                 170                 175                 180

 Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val
                 185                 190                 195

 Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg
                 200                 205                 210

 Gly Glu Cys
            

<210> 20
<211> 121
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 20
 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Arg Thr Phe Thr
                  20                  25                  30

 Ser Tyr Asn Met His Trp Val Arg Gln Met Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Met Gly Ala Ile Tyr Pro Leu Thr Gly Asp Thr Ser Tyr
                  50                  55                  60

 Asn Gln Lys Ser Lys Leu Gln Val Thr Ile Ser Ala Asp Lys Ser
                  65                  70                  75

 Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp
                  80                  85                  90

 Thr Ala Met Tyr Tyr Cys Ala Arg Ser Thr Tyr Val Gly Gly Asp
                  95                 100                 105

 Trp Gln Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser
                 110                 115                 120

 Ser
    

<210> 21
<211> 765
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 21
 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Arg Thr Phe Thr
                  20                  25                  30

 Ser Tyr Asn Met His Trp Val Arg Gln Met Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Met Gly Ala Ile Tyr Pro Leu Thr Gly Asp Thr Ser Tyr
                  50                  55                  60

 Asn Gln Lys Ser Lys Leu Gln Val Thr Ile Ser Ala Asp Lys Ser
                  65                  70                  75

 Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp
                  80                  85                  90

 Thr Ala Met Tyr Tyr Cys Ala Arg Ser Thr Tyr Val Gly Gly Asp
                  95                 100                 105

 Trp Gln Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser
                 110                 115                 120

 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser
                 125                 130                 135

 Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
                 140                 145                 150

 Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly
                 155                 160                 165

 Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser
                 170                 175                 180

 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
                 185                 190                 195

 Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
                 200                 205                 210

 Ser Asn Thr Lys Val Asp Lys Lys Ala Glu Pro Lys Ser Cys Asp
                 215                 220                 225

 Lys Thr His Thr Cys Pro Pro Cys Pro Lys Leu Glu Asp Asp Ile
                 230                 235                 240

 Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met Asn Leu Thr
                 245                 250                 255

 Val Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro Tyr Ala
                 260                 265                 270

 Gln Pro Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser Leu
                 275                 280                 285

 Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser
                 290                 295                 300

 Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly Phe Phe Gly Ser
                 305                 310                 315

 Glu Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr
                 320                 325                 330

 Leu Asn Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala Thr Val
                 335                 340                 345

 Leu Ile Trp Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser Ser
                 350                 355                 360

 Leu His Val Tyr Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val
                 365                 370                 375

 Ile Val Val Ser Met Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu
                 380                 385                 390

 Ala Leu Pro Gly Asn Pro Glu Ala Pro Gly Asn Met Gly Leu Phe
                 395                 400                 405

 Asp Gln Gln Leu Ala Leu Gln Trp Val Gln Lys Asn Ile Ala Ala
                 410                 415                 420

 Phe Gly Gly Asn Pro Lys Ser Val Thr Leu Phe Gly Glu Ser Ala
                 425                 430                 435

 Gly Ala Ala Ser Val Ser Leu His Leu Leu Ser Pro Gly Ser His
                 440                 445                 450

 Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser Gly Ser Ala Asn Ala
                 455                 460                 465

 Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg Asn Arg Thr Leu
                 470                 475                 480

 Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn Glu Thr Glu
                 485                 490                 495

 Ile Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile Leu Leu
                 500                 505                 510

 Asn Glu Ala Phe Val Val Pro Tyr Gly Thr Asn Leu Ser Val Asn
                 515                 520                 525

 Phe Gly Pro Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp
                 530                 535                 540

 Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val
                 545                 550                 555

 Gly Val Asn Lys Asp Glu Gly Thr Ala Phe Leu Ala Tyr Gly Ala
                 560                 565                 570

 Pro Gly Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg Lys Glu
                 575                 580                 585

 Phe Gln Glu Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu Phe
                 590                 595                 600

 Gly Lys Glu Ser Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp
                 605                 610                 615

 Gln Arg Pro Glu Asn Tyr Arg Glu Ala Leu Gly Asp Val Val Gly
                 620                 625                 630

 Asp Tyr Asn Phe Ile Cys Pro Ala Leu Glu Phe Thr Lys Lys Phe
                 635                 640                 645

 Ser Glu Trp Gly Asn Asn Ala Phe Phe Tyr Tyr Phe Glu His Arg
                 650                 655                 660

 Ser Ser Lys Leu Pro Trp Pro Glu Trp Met Gly Val Met His Gly
                 665                 670                 675

 Tyr Glu Ile Glu Phe Val Phe Gly Leu Pro Leu Glu Arg Arg Asp
                 680                 685                 690

 Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser Arg Ser Ile Val Lys
                 695                 700                 705

 Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro Asn Glu Thr Gln
                 710                 715                 720

 Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr Glu Gln Lys
                 725                 730                 735

 Tyr Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr Lys Leu
                 740                 745                 750

 Arg Ala Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys Val
                 755                 760                 765

<210> 22
<211> 115
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 22
 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro
   1               5                  10                  15

 Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu
                  20                  25                  30

 His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro
                  35                  40                  45

 Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val
                  50                  55                  60

 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val
                  80                  85                  90

 Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg Thr Val
                 110                 115

<210> 23
<211> 119
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 23
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser
                  20                  25                  30

 Tyr Ser Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
                  35                  40                  45

 Glu Trp Met Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr
                  50                  55                  60

 Asn Gly Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser
                  65                  70                  75

 Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe Asp Gly Tyr Trp
                  95                 100                 105

 Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115                

<210> 24
<211> 106
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 24
 Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro
   1               5                  10                  15

 Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser
                  20                  25                  30

 Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro
                  35                  40                  45

 Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg
                  50                  55                  60

 Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser
                  65                  70                  75

 Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp
                  80                  85                  90

 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
                  95                 100                 105

 Lys
    

<210> 25
<211> 121
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 25
 Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr
                  50                  55                  60

 Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser
                  65                  70                  75

 Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp
                  80                  85                  90

 Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser
                  95                 100                 105

 Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val
                 110                 115                 120

 Ser
    

