
                                SEQUENCE LISTING

<110> Macrogenics, Inc.
      Johnson, Leslie S.
      Huang, Ling

<120> COVALENT DIABODIES AND USES THEREOF
  

<130> 1301.0007I2

<140>
<141>

<150> 60/945,523          
<151> 2007-06-21  

<150> 60/019,051  
<151> 2008-01-04

<160> 104

<170> PatentIn version 3.4

<210> 1
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> human IgG1 hinge

<400> 1
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
 1               5                  10              


<210> 2
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> human IgG2 hinge

<400> 2
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro
 1               5                  10  


<210> 3
<211> 60
<212> PRT
<213> Homo sapiens

<220> 
<223> human IgG3 hinge

<400> 3
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys
 1               5                  10                  15      
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro
            20                  25                  30          
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu
        35                  40                  45              
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg
    50                  55                  60  


<210> 4

<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> human IgG4 hinge

<400> 4
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser
 1               5                  10  


<210> 5
<211> 217
<212> PRT
<213> Homo sapiens

<220> 
<223> human IgG1 Fc domain

<400> 5
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
            100                 105                 110         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
        115                 120                 125             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    130                 135                 140                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
145                 150                 155                 160 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
                165                 170                 175     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            180                 185                 190         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        195                 200                 205             
Lys Ser Leu Ser Leu Ser Pro Gly Lys
    210                 215         


<210> 6
<211> 216
<212> PRT
<213> Homo sapiens

<220> 
<223> human IgG2 Fc domain

<400> 6
Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
 1               5                  10                  15      
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
            20                  25                  30          
Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
        35                  40                  45              
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
    50                  55                  60                  
Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln
65                  70                  75                  80  
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
                85                  90                  95      
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro
            100                 105                 110         

Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
        115                 120                 125             
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
    130                 135                 140                 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
145                 150                 155                 160 
Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
                165                 170                 175     
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
            180                 185                 190         
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
        195                 200                 205             
Ser Leu Ser Leu Ser Pro Gly Lys
    210                 215     


<210> 7
<211> 217
<212> PRT
<213> Homo sapiens

<220> 
<223> human IgG3 Fc domain

<400> 7
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr
        35                  40                  45              
Val Asp Gly Val Gln Val His Asn Ala Lys Thr Lys Pro Arg Glu Gln
    50                  55                  60                  
Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asn Trp Leu Asp Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln
            100                 105                 110         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
        115                 120                 125             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    130                 135                 140                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn
145                 150                 155                 160 
Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu
                165                 170                 175     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile
            180                 185                 190         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln
        195                 200                 205             
Lys Ser Leu Ser Leu Ser Pro Gly Lys
    210                 215         


<210> 8
<211> 217
<212> PRT
<213> Homo sapiens

<220> 
<223> human IgG4 Fc domain

<400> 8
Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
            100                 105                 110         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
        115                 120                 125             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    130                 135                 140                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
145                 150                 155                 160 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
                165                 170                 175     
Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
            180                 185                 190         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        195                 200                 205             
Lys Ser Leu Ser Leu Ser Leu Gly Lys
    210                 215         


<210> 9
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Diabody Construct 1

<400> 9
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
 1               5                  10                  15      
Glu Lys Val Thr Phe Thr Cys Arg Thr Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Lys Glu Val Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Thr Trp Pro Phe
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly
            100                 105                 110         
Gly Gly Gly Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys
        115                 120                 125             
Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu
    130                 135                 140                 
Ser Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys
145                 150                 155                 160 
Ala Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr
                165                 170                 175     
Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys
            180                 185                 190         
Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala
        195                 200                 205             
Thr Tyr Tyr Cys Ala Gln Ile Asn Pro Ala Trp Phe Ala Tyr Trp Gly
    210                 215                 220                 
Gln Gly Thr Leu Val Thr Val Ser Ser Leu Gly Gly Cys
225                 230                 235         


<210> 10
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker

<400> 10
Gly Gly Gly Ser Gly Gly Gly Gly
 1               5              


<210> 11
<211> 244
<212> PRT
<213> Artificial Sequence

<220> 
<223> Diabody Construct 2

<400> 11
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Phe Asp
            20                  25                  30          
Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly
            100                 105                 110         
Gly Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala
        115                 120                 125             
Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser
    130                 135                 140                 
Gly Tyr Thr Phe Thr Asn Tyr Trp Ile His Trp Val Arg Gln Ala Pro
145                 150                 155                 160 
Gly Gln Gly Leu Glu Trp Ile Gly Val Ile Asp Pro Ser Asp Thr Tyr
                165                 170                 175     
Pro Asn Tyr Asn Lys Lys Phe Lys Gly Arg Val Thr Met Thr Val Val
            180                 185                 190         
Val Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp
        195                 200                 205             
Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Gly Asp Ser Asp Tyr Tyr
    210                 215                 220                 
Ser Gly Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
225                 230                 235                 240 
Leu Gly Gly Cys
                


<210> 12
<211> 240
<212> PRT
<213> Artificial Sequence

<220> 
<223> Diabody Construct 3

<400> 12
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
 1               5                  10                  15      
Glu Lys Val Thr Phe Thr Cys Arg Thr Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Lys Glu Val Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Thr Trp Pro Phe
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly
            100                 105                 110         
Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
        115                 120                 125             
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
    130                 135                 140                 
Thr Asn Tyr Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
145                 150                 155                 160 
Glu Trp Ile Gly Val Ile Asp Pro Ser Asp Thr Tyr Pro Asn Tyr Asn
                165                 170                 175     
Lys Lys Phe Lys Gly Arg Val Thr Met Thr Val Val Val Ser Thr Ser
            180                 185                 190         
Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val
        195                 200                 205             
Tyr Tyr Cys Ala Arg Asn Gly Asp Ser Asp Tyr Tyr Ser Gly Met Asp
    210                 215                 220                 
Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Leu Gly Gly Cys
225                 230                 235                 240 


<210> 13
<211> 241
<212> PRT
<213> Artificial Sequence

<220> 
<223> Diabody Construct 4

<400> 13
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Phe Asp
            20                  25                  30          
Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly
            100                 105                 110         
Gly Gly Ser Gly Gly Gly Gly Gln Val Thr Leu Arg Glu Ser Gly Pro
        115                 120                 125             
Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser
    130                 135                 140                 
Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln
145                 150                 155                 160 
Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp
                165                 170                 175     
Asp Lys Arg Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys
            180                 185                 190         
Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro
        195                 200                 205             
Val Asp Thr Ala Thr Tyr Tyr Cys Ala Gln Ile Asn Pro Ala Trp Phe
    210                 215                 220                 
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Leu Gly Gly
225                 230                 235                 240 
Cys
    


<210> 14
<211> 470
<212> PRT
<213> Artificial Sequence

<220> 
<223> Diabody Construct 5

<400> 14
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
 1               5                  10                  15      
Glu Lys Val Thr Phe Thr Cys Arg Thr Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Lys Glu Val Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Thr Trp Pro Phe
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly
            100                 105                 110         
Gly Gly Gly Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys
        115                 120                 125             
Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu
    130                 135                 140                 
Ser Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys
145                 150                 155                 160 
Ala Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr
                165                 170                 175     
Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys
            180                 185                 190         
Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala
        195                 200                 205             
Thr Tyr Tyr Cys Ala Gln Ile Asn Pro Ala Trp Phe Ala Tyr Trp Gly
    210                 215                 220                 
Gln Gly Thr Leu Val Thr Val Ser Ser Leu Gly Gly Cys Val Glu Pro
225                 230                 235                 240 
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
                245                 250                 255     
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
            260                 265                 270         
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
        275                 280                 285             
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
    290                 295                 300                 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
305                 310                 315                 320 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
                325                 330                 335     
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
            340                 345                 350         
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
        355                 360                 365             
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
    370                 375                 380                 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
385                 390                 395                 400 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
                405                 410                 415     
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
            420                 425                 430         
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
        435                 440                 445             
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
    450                 455                 460                 
Ser Leu Ser Pro Gly Lys
465                 470 


<210> 15
<211> 477
<212> PRT
<213> Artificial Sequence

<220> 
<223> Diabody Construct 6

<400> 15
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Phe Asp
            20                  25                  30          
Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly
            100                 105                 110         
Gly Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala
        115                 120                 125             
Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser
    130                 135                 140                 
Gly Tyr Thr Phe Thr Asn Tyr Trp Ile His Trp Val Arg Gln Ala Pro
145                 150                 155                 160 
Gly Gln Gly Leu Glu Trp Ile Gly Val Ile Asp Pro Ser Asp Thr Tyr
                165                 170                 175     
Pro Asn Tyr Asn Lys Lys Phe Lys Gly Arg Val Thr Met Thr Val Val
            180                 185                 190         
Val Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp
        195                 200                 205             
Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Gly Asp Ser Asp Tyr Tyr
    210                 215                 220                 
Ser Gly Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
225                 230                 235                 240 
Leu Gly Gly Cys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys
                245                 250                 255     
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
            260                 265                 270         
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
        275                 280                 285             
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
    290                 295                 300                 
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
305                 310                 315                 320 
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
                325                 330                 335     
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
            340                 345                 350         
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
        355                 360                 365             
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
    370                 375                 380                 
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
385                 390                 395                 400 
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
                405                 410                 415     
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
            420                 425                 430         
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
        435                 440                 445             
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
    450                 455                 460                 
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
465                 470                 475         


<210> 16
<211> 243
<212> PRT
<213> Artificial Sequence

<220> 
<223> Diabody Construct 7

<400> 16
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
 1               5                  10                  15      
Glu Lys Val Thr Phe Thr Cys Arg Thr Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Lys Glu Val Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Thr Trp Pro Phe
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly
            100                 105                 110         
Gly Gly Gly Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys
        115                 120                 125             
Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu
    130                 135                 140                 
Ser Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys
145                 150                 155                 160 
Ala Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr
                165                 170                 175     
Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys
            180                 185                 190         
Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala
        195                 200                 205             
Thr Tyr Tyr Cys Ala Gln Ile Asn Pro Ala Trp Phe Ala Tyr Trp Gly
    210                 215                 220                 
Gln Gly Thr Leu Val Thr Val Ser Ser Leu Gly Gly Cys Phe Asn Arg
225                 230                 235                 240 
Gly Glu Cys
            


<210> 17
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker plus C-terminus of human IgG-kappa chain

<400> 17
Leu Gly Gly Cys Phe Asn Arg Gly Glu Cys
 1               5                  10  


<210> 18
<211> 477
<212> PRT
<213> Artificial Sequence

<220> 
<223> Diabody Construct 8

<400> 18
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Phe Asp
            20                  25                  30          
Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly
            100                 105                 110         
Gly Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala
        115                 120                 125             
Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser
    130                 135                 140                 
Gly Tyr Thr Phe Thr Asn Tyr Trp Ile His Trp Val Arg Gln Ala Pro
145                 150                 155                 160 
Gly Gln Gly Leu Glu Trp Ile Gly Val Ile Asp Pro Ser Asp Thr Tyr
                165                 170                 175     
Pro Asn Tyr Asn Lys Lys Phe Lys Gly Arg Val Thr Met Thr Val Val
            180                 185                 190         
Val Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp
        195                 200                 205             
Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Gly Asp Ser Asp Tyr Tyr
    210                 215                 220                 
Ser Gly Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
225                 230                 235                 240 
Leu Gly Gly Cys Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys
                245                 250                 255     
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
            260                 265                 270         
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
        275                 280                 285             
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
    290                 295                 300                 
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
305                 310                 315                 320 
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
                325                 330                 335     
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
            340                 345                 350         
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
        355                 360                 365             
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
    370                 375                 380                 
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
385                 390                 395                 400 
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
                405                 410                 415     
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
            420                 425                 430         
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
        435                 440                 445             
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
    450                 455                 460                 
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
465                 470                 475         


<210> 19
<211> 485
<212> PRT
<213> Artificial Sequence

<220> 
<223> Diabody Construct 9

<400> 19
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15      
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
            20                  25                  30          
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
        35                  40                  45              
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
    50                  55                  60                  
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
65                  70                  75                  80  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                85                  90                  95      
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
            100                 105                 110         
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
        115                 120                 125             
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
    130                 135                 140                 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
145                 150                 155                 160 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                165                 170                 175     
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
            180                 185                 190         
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
        195                 200                 205             
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
    210                 215                 220                 
Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Ser Gly Gly Gly
225                 230                 235                 240 
Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu
                245                 250                 255     
Gly Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Phe
            260                 265                 270         
Asp Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro
        275                 280                 285             
Pro Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Val Pro
    290                 295                 300                 
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
305                 310                 315                 320 
Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser
                325                 330                 335     
Asn Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            340                 345                 350         
Gly Gly Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly
        355                 360                 365             
Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala
    370                 375                 380                 
Ser Gly Tyr Thr Phe Thr Asn Tyr Trp Ile His Trp Val Arg Gln Ala
385                 390                 395                 400 
Pro Gly Gln Gly Leu Glu Trp Ile Gly Val Ile Asp Pro Ser Asp Thr
                405                 410                 415     
Tyr Pro Asn Tyr Asn Lys Lys Phe Lys Gly Arg Val Thr Met Thr Val
            420                 425                 430         
Val Val Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser
        435                 440                 445             
Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Gly Asp Ser Asp Tyr
    450                 455                 460                 
Tyr Ser Gly Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
465                 470                 475                 480 
Ser Leu Gly Gly Cys
                485 


<210> 20
<211> 469
<212> PRT
<213> Artificial Sequence

<220> 
<223> Diabody Construct 10

<400> 20
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
            100                 105                 110         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
        115                 120                 125             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    130                 135                 140                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
145                 150                 155                 160 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
                165                 170                 175     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            180                 185                 190         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        195                 200                 205             
Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Ser Gly Gly Gly
    210                 215                 220                 
Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu
225                 230                 235                 240 
Gly Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Phe
                245                 250                 255     
Asp Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro

            260                 265                 270         
Pro Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Val Pro
        275                 280                 285             
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
    290                 295                 300                 
Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser
305                 310                 315                 320 
Asn Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
                325                 330                 335     
Gly Gly Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly
            340                 345                 350         
Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala
        355                 360                 365             
Ser Gly Tyr Thr Phe Thr Asn Tyr Trp Ile His Trp Val Arg Gln Ala
    370                 375                 380                 
Pro Gly Gln Gly Leu Glu Trp Ile Gly Val Ile Asp Pro Ser Asp Thr
385                 390                 395                 400 
Tyr Pro Asn Tyr Asn Lys Lys Phe Lys Gly Arg Val Thr Met Thr Val
                405                 410                 415     
Val Val Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser
            420                 425                 430         
Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Gly Asp Ser Asp Tyr
        435                 440                 445             
Tyr Ser Gly Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
    450                 455                 460                 
Ser Leu Gly Gly Cys
465                 


<210> 21
<211> 466
<212> PRT
<213> Artificial Sequence

<220> 
<223> Diabody Construct 11

<400> 21
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
 1               5                  10                  15      
Glu Lys Val Thr Phe Thr Cys Arg Thr Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Lys Glu Val Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Thr Trp Pro Phe
                85                  90                  95      
Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly
            100                 105                 110         
Gly Gly Gly Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys
        115                 120                 125             
Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu
    130                 135                 140                 
Ser Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys
145                 150                 155                 160 
Ala Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr
                165                 170                 175     
Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys
            180                 185                 190         
Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala
        195                 200                 205             
Thr Tyr Tyr Cys Ala Gln Ile Asn Pro Ala Trp Phe Ala Tyr Trp Gly
    210                 215                 220                 
Gln Gly Thr Leu Val Thr Val Ser Ser Val Glu Pro Lys Ser Cys Asp
225                 230                 235                 240 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
                245                 250                 255     
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
            260                 265                 270         
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
        275                 280                 285             
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
    290                 295                 300                 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
305                 310                 315                 320 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
                325                 330                 335     
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
            340                 345                 350         
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
        355                 360                 365             
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
    370                 375                 380                 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
385                 390                 395                 400 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
                405                 410                 415     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
            420                 425                 430         
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
        435                 440                 445             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
    450                 455                 460                 
Gly Lys
465     


<210> 22
<211> 246
<212> PRT
<213> Artificial Sequence

<220> 
<223> Diabody Construct 12

<400> 22
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Phe Asp
            20                  25                  30          
Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly
            100                 105                 110         
Gly Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala
        115                 120                 125             
Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser
    130                 135                 140                 
Gly Tyr Thr Phe Thr Asn Tyr Trp Ile His Trp Val Arg Gln Ala Pro
145                 150                 155                 160 
Gly Gln Cys Leu Glu Trp Ile Gly Val Ile Asp Pro Ser Asp Thr Tyr
                165                 170                 175     
Pro Asn Tyr Asn Lys Lys Phe Lys Gly Arg Val Thr Met Thr Val Val
            180                 185                 190         
Val Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp
        195                 200                 205             
Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Gly Asp Ser Asp Tyr Tyr
    210                 215                 220                 
Ser Gly Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
225                 230                 235                 240 
Phe Asn Arg Gly Glu Cys
                245     


<210> 23
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> C-terminus of human IgG Kappa chain

<400> 23
Phe Asn Arg Gly Glu Cys
 1               5      


<210> 24
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2B6 Heavy chain variable region - CDR1

<400> 24
Asn Tyr Trp Ile His
 1               5  


<210> 25
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3H7 Heavy Chian Variable region - CDR1

<400> 25
Asp Ala Trp Met Asp
 1               5  


<210> 26
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2B6 Heavy chain variable region - CDR2

<400> 26
Val Ile Asp Pro Ser Asp Thr Tyr Pro Asn Tyr Asn Lys Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 27
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3H7 Heavy Chian Variable region - CDR2

<400> 27
Glu Ile Arg Asn Lys Ala Asn Asn Leu Ala Thr Tyr Tyr Ala Glu Ser
 1               5                  10                  15      
Val Lys Gly
            


<210> 28
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2B6 Heavy chain variable region - CDR3

<400> 28
Asn Gly Asp Ser Asp Tyr Tyr Ser Gly Met Asp Tyr
 1               5                  10          


<210> 29
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3H7 Heavy Chian Variable region - CDR3

<400> 29
Tyr Ser Pro Phe Ala Tyr
 1               5      


<210> 30
<400> 30
000


<210> 31
<400> 31
000

<210> 32
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2B6 Light chain variable region - CDR1

<400> 32
Arg Thr Ser Gln Ser Ile Gly Thr Asn Ile His
 1               5                  10      


<210> 33
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3H7 Light Chian Variable region - CDR1

<400> 33
Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Ser
 1               5                  10      


<210> 34
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2B6 Light chain variable region - CDR2

<400> 34
Asn Val Ser Glu Ser Ile Ser
 1               5          


<210> 35
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2B6 Light chain variable region - CDR2

<400> 35
Tyr Val Ser Glu Ser Ile Ser
 1               5          


<210> 36
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2B6 Light chain variable region - CDR2

<400> 36
Tyr Ala Ser Glu Ser Ile Ser
 1               5          


<210> 37
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3H7 Light Chian Variable region - CDR2

<400> 37
Ala Ala Ser Thr Leu Asp Ser
 1               5          


<210> 38
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2B6 Light chain variable region - CDR3

<400> 38
Gln Gln Ser Asn Thr Trp Pro Phe Thr
 1               5                  


<210> 39
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3H7 Light Chian Variable region - CDR3

<400> 39
Leu Gln Tyr Val Ser Tyr Pro Tyr Thr
 1               5                  


<210> 40
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2B6 heavy chain variable region

<400> 40
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Asp Pro Ser Asp Thr Tyr Pro Asn Tyr Asn Lys Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asn Gly Asp Ser Asp Tyr Tyr Ser Gly Met Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120     


<210> 41
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2B6 light chain variable region - Hu2B6VL-1

<400> 41
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
 1               5                  10                  15      
Glu Lys Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Lys Asn Val Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Thr Trp Pro Phe
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 42
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized 2B6 light chain variable region - Hu2B6VL-2

<400> 42
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
 1               5                  10                  15      
Glu Lys Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Lys Tyr Val Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Thr Trp Pro Phe
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 43
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized 2B6 light chain variable region - Hu2B6VL-3

<400> 43
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
 1               5                  10                  15      
Glu Lys Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Thr Trp Pro Phe
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 44
<211> 107
<212> PRT
<213> mus sp.

<220> 
<223> mouse 3H7 Light Chain Variable Region

<400> 44
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr
            20                  25                  30          
Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Arg Arg Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly
    50                  55                  60                  
Ser Trp Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65                  70                  75                  80  
Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Val Ser Tyr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 45
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG binding site of the Fc-gamma-RIIB receptor

<400> 45
Lys Lys Phe Ser Arg Ser Asp Pro Asn
 1               5                  


<210> 46
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG binding site of the Fc-gamma-RIIB receptor

<400> 46
Gln Lys Phe Ser Arg Leu Asp Pro Asn
 1               5                  


<210> 47
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG binding site of the Fc-gamma-RIIB receptor

<400> 47
Gln Lys Phe Ser Arg Leu Asp Pro Thr
 1               5                  


<210> 48
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG binding site of the Fc-gamma-RIIB receptor

<400> 48
Lys Lys Phe Ser Arg Leu Asp Pro Thr
 1               5                  


<210> 49
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG binding site of the Fc-gamma-RIIB receptor

<400> 49
Gln Lys Phe Ser His Leu Asp Pro Thr
 1               5                  


<210> 50
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG binding site of the Fc-gamma-RIIB receptor

<400> 50
Lys Lys Phe Ser His Leu Asp Pro Thr
 1               5                  


<210> 51
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG binding site of the Fc-gamma-RIIB receptor

<400> 51
Gln Lys Phe Ser Arg Leu Asp Pro Asn
 1               5                  


<210> 52
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG binding site of the Fc-gamma-RIIB receptor

<400> 52
Lys Lys Phe Ser Arg Ser Asp Pro Asn
 1               5                  


<210> 53
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG binding site of the Fc-gamma-RIIB receptor

<400> 53
Gln Lys Phe Ser Arg Leu Asp Pro Thr
 1               5                  


<210> 54
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG binding site of the Fc-gamma-RIIB receptor

<400> 54
Gln Lys Phe Ser His Leu Asp Pro Thr
 1               5                  



<210> 55
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG binding site of the Fc-gamma-RIIB receptor

<400> 55
Lys Lys Phe Ser Arg Leu Asp Pro Thr
 1               5                  


<210> 56
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG binding site of the Fc-gamma-RIIB receptor

<400> 56
Lys Lys Phe Ser His Leu Asp Pro Thr
 1               5                  


<210> 57
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Lgh321F primer

<400> 57
cgagctagct ctagatgaga tcacagttct ctctac                           36

<210> 58
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 
<223> Lgh318R primer

<400> 58
gcctccgcct ccggatccgc ctcctttgat ctccaccttg gtccctc               47

<210> 59
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 
<223> Lgh319F primer

<400> 59
ggaggcggat ccggaggcgg aggccaggtt cagctggtgc agtctgg               47

<210> 60
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Lgh320R primer

<400> 60
tttgaattct agcagcctcc cagtgaggag acggtgaccg tgg                   43

<210> 61
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> Lgh315R primer

<400> 61
gcctccgcct ccggatccgc ctcctttgat ctcaagcttg gtcccc                46

<210> 62
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> Lgh316F primer

<400> 62
ggaggcggat ccggaggcgg aggccaggtt accctgagag agtctggc              48

<210> 63
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 

<223> Lgh317R primer

<400> 63
tttgaattcc tagcagcctc ccagtgagct cacagtgacc agagtcc               47

<210> 64
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Lgh339R primer

<400> 64
ctcaacgcag cctcccagtg agctcac                                     27

<210> 65
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> Lgh340R primer

<400> 65
aacgcagcct cccagtgagg agacggtgac c                                31

<210> 66
<211> 27
<212> DNA
<213> Artificial Sequence


<220> 
<223> Lgh366R primer

<400> 66
tttgaattct atttacccgg agacagg                                     27

<210> 67
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Lgh367F primer

<400> 67
ctgggaggct gcgcagagcc caaatcttgt gac                              33

<210> 68
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Lgh368R primer

<400> 68
gtcacaagat ttgggctctg cgcagcctcc cag                              33

<210> 69
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> Lgh369R primer

<400> 69
tttgaattct aacactctcc cctgttgaag cagcctccca gtgaggagac            50

<210> 70
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized anti-CD16A heavy chain variable region(Hu3G8VH-1)

<400> 70
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln
 1               5                  10                  15      
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser
            20                  25                  30          
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
        35                  40                  45              
Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val
65                  70                  75                  80  
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
                85                  90                  95      
Cys Ala Arg Ile Asn Pro Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 71
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized anti-CD16A heavy chain variable region(Hu3G8VH-5)

<400> 71
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln
 1               5                  10                  15      
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser
            20                  25                  30          
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
        35                  40                  45              
Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val
65                  70                  75                  80  
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
                85                  90                  95      
Cys Ala Gln Ile Asn Pro Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 72
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized anti-CD16A heavy chain variable region(Hu3G8VH-22)

<400> 72
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln
 1               5                  10                  15      
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser
            20                  25                  30          
Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
        35                  40                  45              
Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val
65                  70                  75                  80  
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
                85                  90                  95      
Cys Ala Arg Ile Asn Pro Ala Tyr Phe Ala Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser
        115         


<210> 73
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized anti-CD16A light chain variable region(Hu3G8VL-1)

<400> 73
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Phe Asp
            20                  25                  30          
Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110     


<210> 74
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized anti-CD16A light chain variable region(Hu3G8VL-43)

<400> 74
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Asp Phe Asp
            20                  25                  30          
Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Thr Thr Ser Ser Leu Glu Ser Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Ser Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110     


<210> 75
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized anti-CD16A light chain variable region(Hu3G8VL-22)

<400> 75
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Asp Phe Asp
            20                  25                  30          
Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Thr Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Ser Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110     


<210> 76
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> DNA sequence of linker (SEQ ID NO. 10)

<400> 76
ggaggcggat ccggaggcgg aggc                                        24

<210> 77
<211> 18
<212> DNA
<213> Homo sapiens

<220> 
<223> DNA sequence of C-terminus of human IgG Kappa chain

<400> 77
ttcaacaggg gagagtgt                                               18

<210> 78
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Linker plus C-terminus of human IgG Kappa chain

<400> 78
ctgggaggct gcttcaacag gggagagtgt                                  30

<210> 79
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> Human IgG hinge domain

<400> 79
Val Glu Pro Lys Ser Cys
 1               5      


<210> 80
<211> 18
<212> DNA
<213> Homo sapiens

<220> 
<223> Human IgG hinge domain

<400> 80
gttgagccca aatcttgt                                               18

<210> 81
<211> 118
<212> PRT
<213> Homo sapiens

<220> 
<223> VH domain of 3G8 antibody

<400> 81
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Arg Thr Ser
            20                  25                  30          
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val
65                  70                  75                  80  
Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
                85                  90                  95      
Cys Ala Gln Ile Asn Pro Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 82
<211> 354
<212> DNA
<213> Homo sapiens

<220> 
<223> VH domain of 3G8 antibody

<400> 82
caggttaccc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg 60
acttgttctt tctctgggtt ttcactgagg acttctggta tgggtgtagg ctggattcgt 120
cagccttcag ggaagggtct agagtggctg gcacacattt ggtgggatga tgacaagcgc 180
tataatccag ccctgaagag ccgactgaca atctccaagg atacctccag caaccaggta 240
ttcctcaaaa tcgccagtgt ggacactgca gatactgcca catactactg tgctcaaata 300
aaccccgcct ggtttgctta ctggggccaa gggactctgg tcactgtgag ctca       354


<210> 83
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> humanized anti-CD16A heavy chain variable region(Hu3G8VH-5)

<400> 83
caggttaccc tgagagagtc tggccctgcg ctggtgaagc ccacacagac cctcacactg 60
acttgtacct tctctgggtt ttcactgagc acttctggta tgggtgtagg ctggattcgt 120
cagcctcccg ggaaggctct agagtggctg gcacacattt ggtgggatga tgacaagcgc 180
tataatccag ccctgaagag ccgactgaca atctccaagg atacctccaa aaaccaggta 240
gtcctcacaa tgaccaacat ggaccctgtg gatactgcca catactactg tgctcaaata 300
aaccccgcct ggtttgctta ctggggccaa gggactctgg tcactgtgag ctca       354

<210> 84
<211> 111
<212> PRT
<213> Homo sapiens

<220> 
<223> VL domain of 3G8 antibody

<400> 84
Asp Thr Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Phe Asp
            20                  25                  30          
Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Ile Pro Ala
    50                  55                  60                  
Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110     


<210> 85
<211> 333
<212> DNA
<213> Homo sapiens

<220> 
<223> VL domain of 3G8 antibody

<400> 85
gacactgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc 60
atctcctgca aggccagcca aagtgttgat tttgatggtg atagttttat gaactggtac 120
caacagaaac caggacagcc acccaaactc ctcatctata ctacatccaa tctagaatct 180
gggatcccag ccaggtttag tgccagtggg tctgggacag acttcaccct caacatccat 240
cctgtggagg aggaggatac tgcaacctat tactgtcagc aaagtaatga ggatccgtac 300
acgttcggag gggggaccaa gctggaaata aaa                              333

<210> 86
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> humanized anti-CD16A light chain variable region(Hu3G8VL-1)

<400> 86
gacatcgtga tgacccaatc tccagactct ttggctgtgt ctctagggga gagggccacc 60
atcaactgca aggccagcca aagtgttgat tttgatggtg atagttttat gaactggtac 120
caacagaaac caggacagcc acccaaactc ctcatctata ctacatccaa tctagaatct 180
ggggtcccag acaggtttag tggcagtggg tctgggacag acttcaccct caccatcagc 240
agcctgcagg ctgaggatgt ggcagtttat tactgtcagc aaagtaatga ggatccgtac 300
acgttcggac aggggaccaa gcttgagatc aaa                              333

<210> 87
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized 2B6 heavy chain variable region

<400> 87
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Asp Pro Ser Asp Thr Tyr Pro Asn Tyr Asn Lys Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Val Val Val Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asn Gly Asp Ser Asp Tyr Tyr Ser Gly Met Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120     


<210> 88
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<223> humanized 2B6 heavy chain variable region

<400> 88
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc 60
tcctgcaagg cttctggtta cacctttacc aactactgga tacactgggt gcgacaggcc 120
cctggacaag ggcttgagtg gattggagtg attgatcctt ctgatactta tccaaattac 180
aataaaaagt tcaagggcag agtcaccatg accgtagtcg tatccacgag cacagcctac 240
atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagaaacggt 300
gattccgatt attactctgg tatggactac tgggggcaag ggaccacggt caccgtctcc 360
tca                                                               363

<210> 89
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized 2B6 light chain variable region

<400> 89
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Phe Asp
            20                  25                  30          
Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      

Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110     


<210> 90
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> humanized 2B6 light chain variable region

<400> 90
gaaattgtgc tgactcagtc tccagacttt cagtctgtga ctccaaagga gaaagtcacc 60
ttcacctgca ggaccagtca gagcattggc acaaacatac actggtacca gcagaaacca 120
gatcagtctc caaagctcct catcaaggag gtttctgagt ctatctctgg agtcccatcg 180
aggttcagtg gcagtggatc tgggacagat ttcaccctca ccatcaatag cctggaagct 240
gaagatgctg caacgtatta ctgtcaacaa agtaatacct ggccgttcac gttcggcgga 300
gggaccaagg tggagatcaa a                                           321

<210> 91
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> thrombin cleavage recognition site

<400> 91
Leu Val Pro Arg Gly Ser
 1               5      


<210> 92
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor Xa cleavage recognition site

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Glu or Asp

<400> 92
Ile Xaa Gly Arg
 1              


<210> 93
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> enterokinase cleavage recognition site

<400> 93
Asp Asp Asp Asp Lys
 1               5  


<210> 94
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> furin cleavage recognition site

<220> 
<221> VARIANT        
<222> 2, 3
<223> Xaa = Any Amino Acid

<400> 94
Arg Xaa Xaa Arg
 1              


<210> 95
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> preferred furin cleavage recognition site

<220>
<221> VARIANT        
<222> 2
<223> Xaa = Any Amino Acid

<220>
<221> VARIANT        
<222> 3
<223> Xaa = Lys or Arg

<400> 95
Arg Xaa Xaa Arg
 1              


<210> 96
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> AcTEV cleavage recognition site

<400> 96
Glu Asn Leu Tyr Phe Gln Gly
 1               5          


<210> 97
<211> 487
<212> PRT
<213> Artificial Sequence

<220> 
<223> covalent diabody polyprotein precursor

<400> 97
Asp Thr Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Phe Asp
            20                  25                  30          
Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Ile Pro Ala
    50                  55                  60                  
Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly
            100                 105                 110         
Gly Gly Ser Gly Gly Gly Gly Glu Val Glu Leu Val Glu Ser Gly Gly
        115                 120                 125             
Gly Leu Val Gln Pro Gly Arg Ser Leu Lys Leu Ser Cys Ala Ala Ser
    130                 135                 140                 
Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ala Trp Val Arg Gln Ala Pro
145                 150                 155                 160 
Thr Thr Gly Leu Glu Trp Val Ala Ser Ile Ser Tyr Asp Gly Gly Asp
                165                 170                 175     
Thr His Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp
            180                 185                 190         
Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu
        195                 200                 205             
Asp Thr Ala Thr Tyr Tyr Cys Ala Thr Glu Thr Thr Gly Ile Pro Thr
    210                 215                 220                 
Gly Val Met Asp Ala Trp Gly Gln Gly Val Ser Val Thr Val Ser Ser
225                 230                 235                 240 
Leu Gly Gly Cys Gly Gly Arg Ala Lys Arg Asp Val Gln Met Thr Gln
                245                 250                 255     
Ser Pro Ser Asn Leu Ala Ala Ser Pro Gly Glu Ser Val Ser Ile Asn
            260                 265                 270         
Cys Lys Ala Ser Glu Ser Ile Ser Lys Tyr Leu Ala Trp Tyr Leu Gln
        275                 280                 285             
Lys Pro Gly Lys Ala Asn Lys Leu Leu Met Tyr Asp Gly Ser Thr Leu
    290                 295                 300                 
Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
305                 310                 315                 320 
Phe Thr Leu Thr Ile Arg Ser Leu Glu Pro Glu Asp Phe Gly Leu Tyr
                325                 330                 335     
Tyr Cys Gln Gln His Tyr Glu Tyr Pro Ala Thr Phe Gly Ser Gly Thr
            340                 345                 350         
Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly Gly Gly Gly Gln Val Thr
        355                 360                 365             
Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln Thr Leu Ser
    370                 375                 380                 
Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Arg Thr Ser Gly Met Gly
385                 390                 395                 400 
Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu Trp Leu Ala
                405                 410                 415     
His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys Ser
            420                 425                 430         
Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val Phe Leu Lys
        435                 440                 445             
Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Gln
    450                 455                 460                 
Ile Asn Pro Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
465                 470                 475                 480 
Val Ser Ser Leu Gly Gly Cys
                485         


<210> 98
<211> 1464
<212> DNA
<213> Artificial Sequence

<220> 
<223> covalent diabody polyprotein precursor (DNA sequence of 
      SEQ ID NO. 97)

<400> 98
gacactgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc 60
atctcctgca aggccagcca aagtgttgat tttgatggtg atagttttat gaactggtac 120

caacagaaac caggacagcc acccaaactc ctcatctata ctacatccaa tctagaatct 180
gggatcccag ccaggtttag tgccagtggg tctgggacag acttcaccct caacatccat 240
cctgtggagg aggaggatac tgcaacctat tactgtcagc aaagtaatga ggatccgtac 300
acgttcggag gggggaccaa gctggaaata aaaggaggcg gatccggagg cggaggcgag 360
gtggagctag tggagtctgg gggaggctta gtgcagcctg gaaggtccct gaaactctcg 420
tgtgcagcct caggattcac tttcagtgac tattacatgg cctgggtccg gcaggctcca 480
acgacgggtc tggagtgggt cgcatccatt agttatgatg gtggtgacac tcactatcga 540
gactccgtga agggccgatt tactatttcc agagataatg caaaaagcag cctatacctg 600
caaatggaca gtctgaggtc tgaggacacg gccacttatt actgtgcaac agagactacg 660
ggaataccta caggtgttat ggatgcctgg ggtcaaggag tttcagtcac tgtctcctca 720
ctgggaggct gcggcgggag agctaagagg gatgtccaga tgacccagtc tccatctaat 780
cttgctgcct ctcctggaga aagtgtttcc atcaattgca aggcaagtga gagcattagc 840
aagtatttag cctggtatct acagaaacct gggaaagcaa ataagcttct tatgtacgat 900
gggtcaactt tgcaatctgg aattccatcg aggttcagtg gcagtggatc tggtacagat 960
ttcactctca ccatcagaag cctggagcct gaagattttg gactctatta ctgtcaacag 1020
cattatgaat atccagccac gttcggttct gggaccaagc tggagatcaa aggaggcgga 1080
tccggaggcg gaggccaggt taccctgaaa gagtctggcc ctgggatatt gcagccctcc 1140
cagaccctca gtctgacttg ttctttctct gggttttcac tgaggacttc tggtatgggt 1200
gtaggctgga ttcgtcagcc ttcagggaag ggtctagagt ggctggcaca catttggtgg 1260
gatgatgaca agcgctataa tccagccctg aagagccgac tgacaatctc caaggatacc 1320
tccagcaacc aggtattcct caaaatcgcc agtgtggaca ctgcagatac tgccacatac 1380
tactgtgctc aaataaaccc cgcctggttt gcttactggg gccaagggac tctggtcact 1440
gtgagctcac tgggaggctg ctag                                        1464

<210> 99
<211> 511
<212> PRT
<213> Artificial Sequence

<220> 
<223> covalent diabody polyprotein precursor 

<400> 99
Asp Thr Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Phe Asp
            20                  25                  30          
Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Ile Pro Ala
    50                  55                  60                  
Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly
            100                 105                 110         
Gly Gly Ser Gly Gly Gly Gly Glu Val Glu Leu Val Glu Ser Gly Gly
        115                 120                 125             
Gly Leu Val Gln Pro Gly Arg Ser Leu Lys Leu Ser Cys Ala Ala Ser
    130                 135                 140                 
Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ala Trp Val Arg Gln Ala Pro
145                 150                 155                 160 
Thr Thr Gly Leu Glu Trp Val Ala Ser Ile Ser Tyr Asp Gly Gly Asp
                165                 170                 175     
Thr His Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp
            180                 185                 190         
Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu
        195                 200                 205             
Asp Thr Ala Thr Tyr Tyr Cys Ala Thr Glu Thr Thr Gly Ile Pro Thr
    210                 215                 220                 
Gly Val Met Asp Ala Trp Gly Gln Gly Val Ser Val Thr Val Ser Ser
225                 230                 235                 240 
Leu Gly Gly Cys Gly Gly Arg Ala Lys Arg Ala Pro Val Lys Gln Thr
                245                 250                 255     
Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro
            260                 265                 270         
Gly Pro Asp Val Gln Met Thr Gln Ser Pro Ser Asn Leu Ala Ala Ser
        275                 280                 285             
Pro Gly Glu Ser Val Ser Ile Asn Cys Lys Ala Ser Glu Ser Ile Ser
    290                 295                 300                 
Lys Tyr Leu Ala Trp Tyr Leu Gln Lys Pro Gly Lys Ala Asn Lys Leu
305                 310                 315                 320 
Leu Met Tyr Asp Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe
                325                 330                 335     
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Arg Ser Leu
            340                 345                 350         
Glu Pro Glu Asp Phe Gly Leu Tyr Tyr Cys Gln Gln His Tyr Glu Tyr
        355                 360                 365             
Pro Ala Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly
    370                 375                 380                 
Ser Gly Gly Gly Gly Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile
385                 390                 395                 400 
Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe
                405                 410                 415     
Ser Leu Arg Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser
            420                 425                 430         
Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys
        435                 440                 445             
Arg Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr
    450                 455                 460                 
Ser Ser Asn Gln Val Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp
465                 470                 475                 480 
Thr Ala Thr Tyr Tyr Cys Ala Gln Ile Asn Pro Ala Trp Phe Ala Tyr
                485                 490                 495     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Leu Gly Gly Cys
            500                 505                 510     


<210> 100
<211> 1536
<212> DNA
<213> Artificial Sequence

<220> 
<223> covalent diabody polyprotein precursor (DNA sequence of 
      SEQ ID NO. 99)

<400> 100
gacactgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc 60
atctcctgca aggccagcca aagtgttgat tttgatggtg atagttttat gaactggtac 120
caacagaaac caggacagcc acccaaactc ctcatctata ctacatccaa tctagaatct 180
gggatcccag ccaggtttag tgccagtggg tctgggacag acttcaccct caacatccat 240
cctgtggagg aggaggatac tgcaacctat tactgtcagc aaagtaatga ggatccgtac 300
acgttcggag gggggaccaa gctggaaata aaaggaggcg gatccggagg cggaggcgag 360
gtggagctag tggagtctgg gggaggctta gtgcagcctg gaaggtccct gaaactctcg 420
tgtgcagcct caggattcac tttcagtgac tattacatgg cctgggtccg gcaggctcca 480
acgacgggtc tggagtgggt cgcatccatt agttatgatg gtggtgacac tcactatcga 540
gactccgtga agggccgatt tactatttcc agagataatg caaaaagcag cctatacctg 600
caaatggaca gtctgaggtc tgaggacacg gccacttatt actgtgcaac agagactacg 660
ggaataccta caggtgttat ggatgcctgg ggtcaaggag tttcagtcac tgtctcctca 720
ctgggaggct gcggcgggag agctaagagg gcccctgtga agcagaccct gaacttcgac 780
ctgctgaagc tggccggaga cgtggagagc aaccccggcc ccgatgtcca gatgacccag 840
tctccatcta atcttgctgc ctctcctgga gaaagtgttt ccatcaattg caaggcaagt 900
gagagcatta gcaagtattt agcctggtat ctacagaaac ctgggaaagc aaataagctt 960
cttatgtacg atgggtcaac tttgcaatct ggaattccat cgaggttcag tggcagtgga 1020
tctggtacag atttcactct caccatcaga agcctggagc ctgaagattt tggactctat 1080
tactgtcaac agcattatga atatccagcc acgttcggtt ctgggaccaa gctggagatc 1140
aaaggaggcg gatccggagg cggaggccag gttaccctga aagagtctgg ccctgggata 1200
ttgcagccct cccagaccct cagtctgact tgttctttct ctgggttttc actgaggact 1260
tctggtatgg gtgtaggctg gattcgtcag ccttcaggga agggtctaga gtggctggca 1320
cacatttggt gggatgatga caagcgctat aatccagccc tgaagagccg actgacaatc 1380
tccaaggata cctccagcaa ccaggtattc ctcaaaatcg ccagtgtgga cactgcagat 1440
actgccacat actactgtgc tcaaataaac cccgcctggt ttgcttactg gggccaaggg 1500
actctggtca ctgtgagctc actgggaggc tgctag                           1536

<210> 101
<211> 239
<212> PRT
<213> Artificial Sequence

<220> 
<223> Diabody construct 

<400> 101
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
 1               5                  10                  15      
Glu Lys Val Thr Phe Thr Cys Arg Thr Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Lys Glu Val Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Thr Trp Pro Phe
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly
            100                 105                 110         
Gly Gly Gly Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys
        115                 120                 125             
Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu
    130                 135                 140                 
Ser Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys
145                 150                 155                 160 
Ala Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr
                165                 170                 175     
Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys
            180                 185                 190         
Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala
        195                 200                 205             
Thr Tyr Tyr Cys Ala Gln Ile Asn Pro Ala Trp Phe Ala Tyr Trp Gly
    210                 215                 220                 
Gln Gly Thr Leu Val Thr Val Ser Ser Phe Asn Arg Gly Glu Cys
225                 230                 235                 


<210> 102
<211> 720
<212> DNA
<213> Artificial Sequence

<220> 
<223> Diabody construct (DNA sequence of SEQ ID NO. 101)

<400> 102
gaaattgtgc tgactcagtc tccagacttt cagtctgtga ctccaaagga gaaagtcacc 60
ttcacctgca ggaccagtca gagcattggc acaaacatac actggtacca gcagaaacca 120
gatcagtctc caaagctcct catcaaggag gtttctgagt ctatctctgg agtcccatcg 180
aggttcagtg gcagtggatc tgggacagat ttcaccctca ccatcaatag cctggaagct 240
gaagatgctg caacgtatta ctgtcaacaa agtaatacct ggccgttcac gttcggcgga 300
gggaccaagg tggagatcaa aggaggcgga tccggaggcg gaggccaggt taccctgaga 360
gagtctggcc ctgcgctggt gaagcccaca cagaccctca cactgacttg taccttctct 420
gggttttcac tgagcacttc tggtatgggt gtaggctgga ttcgtcagcc tcccgggaag 480
gctctagagt ggctggcaca catttggtgg gatgatgaca agcgctataa tccagccctg 540
aagagccgac tgacaatctc caaggatacc tccaaaaacc aggtagtcct cacaatgacc 600
aacatggacc ctgtggatac tgccacatac tactgtgctc aaataaaccc cgcctggttt 660
gcttactggg gccaagggac tctggtcact gtgagctcat tcaacagggg agagtgttag 720


<210> 103
<211> 246
<212> PRT
<213> Artificial Sequence

<220> 
<223> Diabody construct 

<400> 103
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Phe Asp
            20                  25                  30          
Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly
            100                 105                 110         
Gly Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala
        115                 120                 125             
Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser
    130                 135                 140                 
Gly Tyr Thr Phe Thr Asn Tyr Trp Ile His Trp Val Arg Gln Ala Pro
145                 150                 155                 160 
Gly Gln Gly Leu Glu Trp Ile Gly Val Ile Asp Pro Ser Asp Thr Tyr
                165                 170                 175     
Pro Asn Tyr Asn Lys Lys Phe Lys Gly Arg Val Thr Met Thr Val Val
            180                 185                 190         
Val Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp
        195                 200                 205             
Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Gly Asp Ser Asp Tyr Tyr
    210                 215                 220                 
Ser Gly Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
225                 230                 235                 240 
Val Glu Pro Lys Ser Cys
                245     


<210> 104
<211> 741
<212> DNA
<213> Artificial Sequence

<220> 
<223> Diabody construct (DNA sequence of SEQ ID NO. 103)


<400> 104
gacatcgtga tgacccaatc tccagactct ttggctgtgt ctctagggga gagggccacc 60
atcaactgca aggccagcca aagtgttgat tttgatggtg atagttttat gaactggtac 120
caacagaaac caggacagcc acccaaactc ctcatctata ctacatccaa tctagaatct 180
ggggtcccag acaggtttag tggcagtggg tctgggacag acttcaccct caccatcagc 240
agcctgcagg ctgaggatgt ggcagtttat tactgtcagc aaagtaatga ggatccgtac 300
acgttcggac aggggaccaa gcttgagatc aaaggaggcg gatccggagg cggaggccag 360
gttcagctgg tgcagtctgg agctgaggtg aagaagcctg gggcctcagt gaaggtctcc 420
tgcaaggctt ctggttacac ctttaccaac tactggatac actgggtgcg acaggcccct 480
ggacaagggc ttgagtggat tggagtgatt gatccttctg atacttatcc aaattacaat 540
aaaaagttca agggcagagt caccatgacc gtagtcgtat ccacgagcac agcctacatg 600
gagctgagga gcctgagatc tgacgacacg gccgtgtatt actgtgcgag aaacggtgat 660
tccgattatt actctggtat ggactactgg gggcaaggga ccacggtcac cgtctcctca 720
gttgagccca aatcttgtta g                                           741


<210> 105
<211> 717
<212> DNA
<213> artificial 

<220>
<223> H3G8VL-CB3.1VH

<400> 105
gacatcgtga tgacccaatc tccagactct ttggctgtgt ctctagggga gagggccacc     60

atcaactgca aggccagcca aagtgttgat tttgatggtg atagttttat gaactggtac    120

caacagaaac caggacagcc acccaaactc ctcatctata ctacatccaa tctagaatct    180

ggggtcccag acaggtttag tggcagtggg tctgggacag acttcaccct caccatcagc    240

agcctgcagg ctgaggatgt ggcagtttat tactgtcagc aaagtaatga ggatccgtac    300

acgttcggac aggggaccaa gcttgagatc aaaggaggcg gatccggagg cggaggccag    360

gtccaactgc agcagcctgg ggctgagctg gtgaggcctg gggcttcagt gaagctgtcc    420

tgcaaggctt ctggctacac cttcaccagc tactggatga actgggtgaa gcagaggcct    480

ggacaaggcc ttgaatggat tggtatggtt gatccttcag acagtgaaac tcactacaat    540

caaatgttca aggacaaggc cacattgact gttgacaaat cctccagcac agcctacatg    600

cagctcagca gcctgacatc tgaggactct gcggtctatt actgtgcaag agctatgggc    660

tactggggtc aaggaacctc agtcaccgtc tcctcagttg agcccaaatc ttgttag       717


<210> 106
<211> 238
<212> PRT
<213> artificial

<220>
<223> H3G8VL-CB3.1VH

<400> 106

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Phe Asp 
            20                  25                  30          


Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala 
        115                 120                 125             


Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser 
    130                 135                 140                 


Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro 
145                 150                 155                 160 


Gly Gln Gly Leu Glu Trp Ile Gly Met Val Asp Pro Ser Asp Ser Glu 
                165                 170                 175     


Thr His Tyr Asn Gln Met Phe Lys Asp Lys Ala Thr Leu Thr Val Asp 
            180                 185                 190         


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
        195                 200                 205             


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ala Met Gly Tyr Trp Gly Gln 
    210                 215                 220                 


Gly Thr Ser Val Thr Val Ser Ser Val Glu Pro Lys Ser Cys 
225                 230                 235             


<210> 107
<211> 735
<212> DNA
<213> artificial

<220>
<223> CB3.1VL-h3G8VH

<400>  107
gatgttgtga tgacccagac tccactcact ttgtcggtta acattggaca accagcctcc     60

atctcttgta agtcaagtca gagcctctta gatactgatg gaaagacata tttgaattgg    120

ttgttacaga ggccaggcca gtctccaaac cgcctaatct atctggtgtc taaactggac    180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc    240

agcagagtgg aggctgagga tttgggaatt tattattgct ggcaaggtac acattttccg    300

ctcacgttcg gtgctgggac caagctggag ctgaaaggag gcggatccgg aggcggaggc    360

caggttaccc tgagagagtc tggccctgcg ctggtgaagc ccacacagac cctcacactg    420

acttgtacct tctctgggtt ttcactgagc acttctggta tgggtgtagg ctggattcgt    480

cagcctcccg ggaaggctct agagtggctg gcacacattt ggtgggatga tgacaagcgc    540

tataatccag ccctgaagag ccgactgaca atctccaagg atacctccaa aaaccaggta    600

gtcctcacaa tgaccaacat ggaccctgtg gatactgcca catactactg tgctcaaata    660

aaccccgcct ggtttgctta ctggggccaa gggactctgg tcactgtgag ctcattcaac    720

aggggagagt gttag                                                     735


<210> 108
<211> 244
<212> PRT
<213> artificial

<220>
<223> CB3.1VL-h3G8VH

<400> 108

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Asn Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Thr 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Asn Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Gln Val Thr Leu Arg Glu Ser Gly 
        115                 120                 125             


Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe 
    130                 135                 140                 


Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val Gly Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala His Ile Trp Trp Asp 
                165                 170                 175     


Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser 
            180                 185                 190         


Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met Asp 
        195                 200                 205             


Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Gln Ile Asn Pro Ala Trp 
    210                 215                 220                 


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Phe Asn 
225                 230                 235                 240 


Arg Gly Glu Cys 
                


<210> 109
<211> 704
<212> DNA
<213> artificial

<220>
<223> 8B5-CB3.1-VEPKSC

<400> 109
gacattcaga tgacacagtc tccatcctcc ctacttgcgg cgctgggaga aagagtcagt     60

ctcacttgtc gggcaagtca ggaaattagt ggttacttaa gctggcttca gcagaaacca    120

gatggaacta ttaaacgcct gatctacgcc gcatccactt tagattctgg tgtcccaaaa    180

aggttcagtg gcagtgagtc tgggtcagat tattctctca ccatcagcag tcttgagtct    240

gaagattttg cagactatta ctgtctacaa tattttagtt atccgctcac gttcggtgct    300

gggaccaagc tggagctgaa aggaggcgga tccggaggcg gaggccaggt ccaactgcag    360

cagcctgggg ctgagctggt gaggcctggg gcttcagtga agctgtcctg caaggcttct    420

ggctacacct tcaccagcta ctggatgaac tgggtgaagc agaggcctgg acaaggcctt    480

gaatggattg gtatggttga tccttcagac agtgaaactc actacaatca aatgttcaag    540

gaaaggccac attgactgtt gacaaatcct ccagcacagc ctacatgcag ctcagcagcc    600

tgacatctga ggactctgcg gtctattact gtgcaagagc tatgggctac tggggtcaag    660

gaacctcagt caccgtctcc tcagttgagc ccaaatcttg ttag                     704


<210> 110
<211> 234
<212> PRT
<213> artificial

<220>
<223> 8B5-CB3.1-VEPKSC

<400> 110

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Leu Ala Ala Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Phe Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Ile Gly Met Val Asp Pro Ser Asp Ser Glu Thr His Tyr Asn 
                165                 170                 175     


Gln Met Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
            180                 185                 190         


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Ser Val 
    210                 215                 220                 


Thr Val Ser Ser Val Glu Pro Lys Ser Cys 
225                 230                 


<210>  111
<211>  729
<212>  DNA
<213>  artificial

<220>
<223>  CB3.1-8B5-FNRGEC

<400>  111
gatgttgtga tgacccagac tccactcact ttgtcggtta acattggaca accagcctcc     60

atctcttgta agtcaagtca gagcctctta gatactgatg gaaagacata tttgaattgg    120

ttgttacaga ggccaggcca gtctccaaac cgcctaatct atctggtgtc taaactggac    180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc    240

agcagagtgg aggctgagga tttgggaatt tattattgct ggcaaggtac acattttccg    300

ctcacgttcg gtgctgggac caagctggag ctgaaaggag gcggatccgg aggcggaggc    360

gaagtgaagc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc    420

tcttgtgaag cctctggatt cacttttagt gacgcctgga tggactgggt ccgtcagtct    480

ccagagaagg ggcttgagtg ggttgctgaa attagaaaca aagctaaaaa tcatgcaaca    540

tactatgctg agtctgtgat agggaggttc accatctcaa gagatgattc caaaagtagt    600

gtctacctgc aaatgaacag cttaagagct gaagacactg gcatttatta ctgtggggct    660

ctgggccttg actactgggg ccaaggcacc actctcacag tctcctcgtt caacagggga    720

gagtgttag                                                            729


<210>  112
<211>  242
<212>  PRT
<213>  artificial

<220>
<223>  CB3.1-8B5-FNRGEC

<400>  112

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Asn Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Thr 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Asn Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Glu Val Lys Leu Glu Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Met Lys Leu Ser Cys Glu Ala 
    130                 135                 140                 


Ser Gly Phe Thr Phe Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ser 
145                 150                 155                 160 


Pro Glu Lys Gly Leu Glu Trp Val Ala Glu Ile Arg Asn Lys Ala Lys 
                165                 170                 175     


Asn His Ala Thr Tyr Tyr Ala Glu Ser Val Ile Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Gly Ile Tyr Tyr Cys Gly Ala Leu Gly Leu Asp 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Phe Asn Arg Gly 
225                 230                 235                 240 


Glu Cys 
        


<210>  113
<211>  699
<212>  DNA
<213>  artificial

<220>
<223>  8B5VL-CB3.1VH-LGGC

<400>  113
gacattcaga tgacacagtc tccatcctcc ctacttgcgg cgctgggaga aagagtcagt     60

ctcacttgtc gggcaagtca ggaaattagt ggttacttaa gctggcttca gcagaaacca    120

gatggaacta ttaaacgcct gatctacgcc gcatccactt tagattctgg tgtcccaaaa    180

aggttcagtg gcagtgagtc tgggtcagat tattctctca ccatcagcag tcttgagtct    240

gaagattttg cagactatta ctgtctacaa tattttagtt atccgctcac gttcggtgct    300

gggaccaagc tggagctgaa aggaggcgga tccggaggcg gaggccaggt ccaactgcag    360

cagcctgggg ctgagctggt gaggcctggg gcttcagtga agctgtcctg caaggcttct    420

ggctacacct tcaccagcta ctggatgaac tgggtgaagc agaggcctgg acaaggcctt    480

gaatggattg gtatggttga tccttcagac agtgaaactc actacaatca aatgttcaag    540

gacaaggcca cattgactgt tgacaaatcc tccagcacag cctacatgca gctcagcagc    600

ctgacatctg aggactctgc ggtctattac tgtgcaagag ctatgggcta ctggggtcaa    660

ggaacctcag tcaccgtctc ctcactggga ggctgctag                           699


<210>  114
<211>  232
<212>  PRT
<213>  artificial

<220>
<223>  8B5VL-CB3.1VH-LGGC

<400>  114

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Leu Ala Ala Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Phe Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Ile Gly Met Val Asp Pro Ser Asp Ser Glu Thr His Tyr Asn 
                165                 170                 175     


Gln Met Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
            180                 185                 190         


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Ser Val 
    210                 215                 220                 


Thr Val Ser Ser Leu Gly Gly Cys 
225                 230         


<210>  115
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  CB3.1-8B5-LGGC

<400>  115
gatgttgtga tgacccagac tccactcact ttgtcggtta acattggaca accagcctcc     60

atctcttgta agtcaagtca gagcctctta gatactgatg gaaagacata tttgaattgg    120

ttgttacaga ggccaggcca gtctccaaac cgcctaatct atctggtgtc taaactggac    180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc    240

agcagagtgg aggctgagga tttgggaatt tattattgct ggcaaggtac acattttccg    300

ctcacgttcg gtgctgggac caagctggag ctgaaaggag gcggatccgg aggcggaggc    360

gaagtgaagc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc    420

tcttgtgaag cctctggatt cacttttagt gacgcctgga tggactgggt ccgtcagtct    480

ccagagaagg ggcttgagtg ggttgctgaa attagaaaca aagctaaaaa tcatgcaaca    540

tactatgctg agtctgtgat agggaggttc accatctcaa gagatgattc caaaagtagt    600

gtctacctgc aaatgaacag cttaagagct gaagacactg gcatttatta ctgtggggct    660

ctgggccttg actactgggg ccaaggcacc actctcacag tctcctcgct gggaggctgc    720

tag                                                                  723


<210>  116
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  CB3.1-8B5-LGGC

<400>  116

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Asn Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Thr 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Asn Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Glu Val Lys Leu Glu Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Met Lys Leu Ser Cys Glu Ala 
    130                 135                 140                 


Ser Gly Phe Thr Phe Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ser 
145                 150                 155                 160 


Pro Glu Lys Gly Leu Glu Trp Val Ala Glu Ile Arg Asn Lys Ala Lys 
                165                 170                 175     


Asn His Ala Thr Tyr Tyr Ala Glu Ser Val Ile Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Gly Ile Tyr Tyr Cys Gly Ala Leu Gly Leu Asp 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Leu Gly Gly Cys 
225                 230                 235                 240 


<210>  117
<211>  47
<212>  DNA
<213>  artificial

<220>
<223>  Primer Lgh628F

<400>  117
ggaggcggat ccggaggcgg aggccaggtc caactgcagc agcctgg                   47


<210>  118
<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  Primer Lgh629R

<400>  118
tttgaattct aacaagattt gggctcaact gaggagacgg tgactgagg                 49


<210>  119
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  Primer Lgh630R

<400>  119
gcctccgcct ccggatccgc ctcctttcag ctccagcttg gtccc                     45


<210>  120
<211>  47
<212>  DNA
<213>  artificial

<220>
<223>  Primer Lgh631F

<400>  120
ggaggcggat ccggaggcgg aggcgaagtg aagcttgagg agtctgg                   47


<210>  121
<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  Primer Lgh640R

<400>  121
tttgaattct aacactctcc cctgttgaac gaggagactg tgagagtgg                 49


<210>  122
<211>  48
<212>  DNA
<213>  artificial

<220>
<223>  Primer Lgh644R

<400>  122
tttgtcgtca tcatcgtctt tgtagtcgga gtggacacct gtggagag                  48


<210>  123
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  Primer Lgh646R

<400>  123
tttgaattct agcagcctcc cagtgaggag acggtgactg ag                        42


<210>  124
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  Primer Lgh647F

<400>  124
caaagacgat gatgacgaca aagacattca gatgacacag tctcc                     45


<210>  125
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  Primer Lgh648R

<400>  125
tttgaattct agcagcctcc cagcgaggag actgtgagag tgg                       43


<210>  126
<211>  1047
<212>  DNA
<213>  artificial

<220>
<223>  2.4G2-3G8-hKappa

<400>  126
gatgtccaga tgacccagtc tccatctaat cttgctgcct ctcctggaga aagtgtttcc     60

atcaattgca aggcaagtga gagcattagc aagtatttag cctggtatct acagaaacct    120

gggaaagcaa ataagcttct tatgtacgat gggtcaactt tgcaatctgg aattccatcg    180

aggttcagtg gcagtggatc tggtacagat ttcactctca ccatcagaag cctggagcct    240

gaagattttg gactctatta ctgtcaacag cattatgaat atccagccac gttcggttct    300

gggaccaagc tggagatcaa aggaggcgga tccggaggcg gaggccaggt taccctgaaa    360

gagtctggcc ctgggatatt gcagccctcc cagaccctca gtctgacttg ttctttctct    420

gggttttcac tgaggacttc tggtatgggt gtaggctgga ttcgtcagcc ttcagggaag    480

ggtctagagt ggctggcaca catttggtgg gatgatgaca agcgctataa tccagccctg    540

aagagccgac tgacaatctc caaggatacc tccagcaacc aggtattcct caaaatcgcc    600

agtgtggaca ctgcagatac tgccacatac tactgtgctc aaataaaccc cgcctggttt    660

gcttactggg gccaagggac tctggtcact gtgagctcac tgggaggctg cggcggaggg    720

agccgtacgg tggctgcacc atcggtcttc atcttcccgc catctgatga gcagttgaaa    780

tctggaactg cctctgttgt gtgcctgctg aataacttct atcccagaga ggccaaagta    840

cagtggaagg tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag    900

gacagcaagg acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac    960

gagaaacaca aagtctacgc ctgcgaagtc acccatcagg gcctgagctc gcccgtcaca   1020

aagagcttca acaggggaga gtgttag                                       1047


<210>  127
<211>  348
<212>  PRT
<213>  artificial

<220>
<223>  2.4G2-3G8-hKappa

<400>  127

Asp Val Gln Met Thr Gln Ser Pro Ser Asn Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Asn Cys Lys Ala Ser Glu Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Leu Gln Lys Pro Gly Lys Ala Asn Lys Leu Leu Met 
        35                  40                  45              


Tyr Asp Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Arg Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Leu Tyr Tyr Cys Gln Gln His Tyr Glu Tyr Pro Ala 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
        115                 120                 125             


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
    130                 135                 140                 


Arg Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
145                 150                 155                 160 


Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr 
                165                 170                 175     


Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser 
            180                 185                 190         


Asn Gln Val Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala 
        195                 200                 205             


Thr Tyr Tyr Cys Ala Gln Ile Asn Pro Ala Trp Phe Ala Tyr Trp Gly 
    210                 215                 220                 


Gln Gly Thr Leu Val Thr Val Ser Ser Leu Gly Gly Cys Gly Gly Gly 
225                 230                 235                 240 


Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
                245                 250                 255     


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
            260                 265                 270         


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
        275                 280                 285             


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
    290                 295                 300                 


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
305                 310                 315                 320 


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
                325                 330                 335     


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            340                 345             


<210>  128
<211>  1737
<212>  DNA
<213>  artificial

<220>
<223>  3G8-2.4G2-hG1

<400>  128
gacactgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc     60

atctcctgca aggccagcca aagtgttgat tttgatggtg atagttttat gaactggtac    120

caacagaaac caggacagcc acccaaactc ctcatctata ctacatccaa tctagaatct    180

gggatcccag ccaggtttag tgccagtggg tctgggacag acttcaccct caacatccat    240

cctgtggagg aggaggatac tgcaacctat tactgtcagc aaagtaatga ggatccgtac    300

acgttcggag gggggaccaa gctggaaata aaaggaggcg gatccggagg cggaggcgag    360

gtggagctag tggagtctgg gggaggctta gtgcagcctg gaaggtccct gaaactctcg    420

tgtgcagcct caggattcac tttcagtgac tattacatgg cctgggtccg gcaggctcca    480

acgacgggtc tggagtgggt cgcatccatt agttatgatg gtggtgacac tcactatcga    540

gactccgtga agggccgatt tactatttcc agagataatg caaaaagcag cctatacctg    600

caaatggaca gtctgaggtc tgaggacacg gccacttatt actgtgcaac agagactacg    660

ggaataccta caggtgttat ggatgcctgg ggtcaaggag tttcagtcac tgtctcctca    720

ctgggaggct gcggcggagg gagcgcctcc accaagggcc catcggtctt ccccctggca    780

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac    840

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc    900

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc    960

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc   1020

aaggtggaca agagagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc   1080

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac   1140

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa   1200

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca   1260

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg   1320

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca   1380

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac   1440

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc   1500

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac   1560

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag   1620

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat   1680

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatga      1737


<210>  129
<211>  578
<212>  PRT
<213>  artificial

<220>
<223>  3G8-2.4G2-hG1

<400>  129

Asp Thr Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Phe Asp 
            20                  25                  30          


Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Glu Val Glu Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Arg Ser Leu Lys Leu Ser Cys Ala Ala Ser 
    130                 135                 140                 


Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ala Trp Val Arg Gln Ala Pro 
145                 150                 155                 160 


Thr Thr Gly Leu Glu Trp Val Ala Ser Ile Ser Tyr Asp Gly Gly Asp 
                165                 170                 175     


Thr His Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            180                 185                 190         


Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu 
        195                 200                 205             


Asp Thr Ala Thr Tyr Tyr Cys Ala Thr Glu Thr Thr Gly Ile Pro Thr 
    210                 215                 220                 


Gly Val Met Asp Ala Trp Gly Gln Gly Val Ser Val Thr Val Ser Ser 
225                 230                 235                 240 


Leu Gly Gly Cys Gly Gly Gly Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
            260                 265                 270         


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
        275                 280                 285             


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
    290                 295                 300                 


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
305                 310                 315                 320 


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
                325                 330                 335     


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
            340                 345                 350         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        355                 360                 365             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    370                 375                 380                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
385                 390                 395                 400 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                405                 410                 415     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            420                 425                 430         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        435                 440                 445             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    450                 455                 460                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
465                 470                 475                 480 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                485                 490                 495     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            500                 505                 510         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        515                 520                 525             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    530                 535                 540                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
545                 550                 555                 560 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                565                 570                 575     


Gly Lys 
        


<210>  130
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  CD79VL-CD32BVH

<400>  130
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc     60

atctcctgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg    120

tttcagcaga ggccaggcca atctccaaac cgcctaattt atctggtgtc taaactggac    180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc    240

agcagggtgg aggctgagga tgttggggtt tattactgct ggcaaggtac acattttccg    300

ctcacgttcg gcggagggac caagcttgag atcaaaggag gcggatccgg aggcggaggc    360

gaagtgaagc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc    420

tcttgtgaag cctctggatt cacttttagt gacgcctgga tggactgggt ccgtcagtct    480

ccagagaagg ggcttgagtg ggttgctgaa attagaaaca aagctaaaaa tcatgcaaca    540

tactatgctg agtctgtgat agggaggttc accatctcaa gagatgattc caaaagtagt    600

gtctacctgc aaatgaacag cttaagagct gaagacactg gcatttatta ctgtggggct    660

ctgggccttg actactgggg ccaaggcacc actctcacag tctcctcgct gggaggctgc    720

tag                                                                  723


<210>  131
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  CD79-CD32BVH

<400>  131

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Asn Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Phe Thr Phe Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Val Ala Glu Ile Arg Asn Lys Ala Lys 
                165                 170                 175     


Asn His Ala Thr Tyr Tyr Ala Glu Ser Val Ile Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Gly Ala Leu Gly Leu Asp 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Leu Gly Gly Cys 
225                 230                 235                 240 


<210>  132
<211>  699
<212>  DNA
<213>  artificial

<220>
<223>  CD32BVL-CD79VH-1

<400>  132
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctgtgggaga tagagtcacc     60

atcacttgtc gggcaagtca ggaaattagt ggttacttaa gctggctgca gcagaaacca    120

ggcaaggccc ctagacgcct gatctacgcc gcatccactt tagattctgg tgtcccatcc    180

aggttcagtg gcagtgagtc tgggaccgag ttcaccctca ccatcagcag ccttcagcct    240

gaagattttg caacctatta ctgtctacaa tattttagtt atccgctcac gttcggaggg    300

gggaccaagg tggaaataaa aggaggcgga tccggaggcg gaggccaggt tcagctggtg    360

cagtctggag ctgaggtgaa gaagcctggc gcctcagtga aggtctcctg caaggcttct    420

ggttacacct ttaccagcta ctggatgaac tgggtgcgac aggcccctgg acaagggctt    480

gagtggatcg gaatgattga tccttcagac agtgaaactc actacaatca aatgttcaag    540

gacagagtca ccatgaccac agacacatcc acgagcacag cctacatgga gctgaggagc    600

ctgagatctg acgacacggc cgtgtattac tgtgcgagag ctatgggcta ctgggggcaa    660

gggaccacgg tcaccgtctc ctcactggga ggctgctga                           699


<210>  133
<211>  232
<212>  PRT
<213>  artificial

<220>
<223>  CD32BVL-CD79VH-1

<400>  133

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Phe Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Ser Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Ile Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn 
                165                 170                 175     


Gln Met Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
            180                 185                 190         


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Thr Val 
    210                 215                 220                 


Thr Val Ser Ser Leu Gly Gly Cys 
225                 230         


<210>  134
<211>  703
<212>  DNA
<213>  artificial

<220>
<223>  CD32BVL-CD79VH-2

<400>  134
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctgtgggaga tagagtcacc     60

atcacttgtc gggcaagtca ggaaattagt ggttacttaa gctggctgca gcagaaacca    120

ggcaaggccc ctagacgcct gatctacgcc gcatccactt tagattctgg tgtcccatcc    180

aggttcagtg gcagtgagtc tgggaccgag ttcaccctca ccatcagcag ccttcagcct    240

gaagattttg caacctatta ctgtctacaa tattttagtt atccgctcac gttcggaggg    300

gggaccaagg tggaaataaa aggaggcgga tccggaggcg gaggccaggt tcagctggtg    360

cagtctggag ctgaggtgaa gaagcctggc gcctcagtga aggtctcctg caaggcttct    420

ggttacacct ttaccagcta ctggatgaac tgggtgcgac aggcccctgg acaagggctt    480

gagtggatcg gaatgattga tccttcagac agtgaaactc actacaatca aaagttcaag    540

gacagagtca ccatgaccac agacacatcc acgagcacag cctacatgga gctgaggagc    600

ctgagatctg acgacacggc cgtgtattac tgtgcgagag ctatgggcta ctgggggcaa    660

gggaccacgg tcaccgtctc ctcactggga ggctgctgaa ttc                      703


<210>  135
<211>  232
<212>  PRT
<213>  artificial

<220>
<223>  CD32BVL-CD79VH-2

<400>  135

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Phe Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Ser Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Ile Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn 
                165                 170                 175     


Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
            180                 185                 190         


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Thr Val 
    210                 215                 220                 


Thr Val Ser Ser Leu Gly Gly Cys 
225                 230         
















