                         SEQUENCE LISTING

<110>  Emory University
 
<120>  Method of Treating Abnormal Angiogenesis via the BAI family of 
       proteins and their fragments

<130>  050508-2680

<150>  US 60/936,196
<151>  2007-06-19

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  1584
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Gly Gln Ala Ala Ala Pro Gly Pro Val Trp Ile Leu Ala Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Gly Arg Arg Ala Arg Ala Ala Ala 
            20                  25                  30          


Gly Ala Asp Ala Gly Pro Gly Pro Glu Pro Cys Ala Thr Leu Val Gln 
        35                  40                  45              


Gly Lys Phe Phe Gly Tyr Phe Ser Ala Ala Ala Val Phe Pro Ala Asn 
    50                  55                  60                  


Ala Ser Arg Cys Ser Trp Thr Leu Arg Asn Pro Asp Pro Arg Arg Tyr 
65                  70                  75                  80  


Thr Leu Tyr Met Lys Val Ala Lys Ala Pro Val Pro Cys Ser Gly Pro 
                85                  90                  95      


Gly Arg Val Arg Thr Tyr Gln Phe Asp Ser Phe Leu Glu Ser Thr Arg 
            100                 105                 110         


Thr Tyr Leu Gly Val Glu Ser Phe Asp Glu Val Leu Arg Leu Cys Asp 
        115                 120                 125             


Pro Ser Ala Pro Leu Ala Phe Leu Gln Ala Ser Lys Gln Phe Leu Gln 
    130                 135                 140                 


Met Arg Arg Gln Gln Pro Pro Gln His Asp Gly Leu Arg Pro Arg Ala 
145                 150                 155                 160 


Gly Pro Pro Gly Pro Thr Asp Asp Phe Ser Val Glu Tyr Leu Val Val 
                165                 170                 175     


Gly Asn Arg Asn Pro Ser Arg Ala Ala Cys Gln Met Leu Cys Arg Trp 
            180                 185                 190         


Leu Asp Ala Cys Leu Ala Gly Ser Arg Ser Ser His Pro Cys Gly Ile 
        195                 200                 205             


Met Gln Thr Pro Cys Ala Cys Leu Gly Gly Glu Ala Gly Gly Pro Ala 
    210                 215                 220                 


Ala Gly Pro Leu Ala Pro Arg Gly Asp Val Cys Leu Arg Asp Ala Val 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asn Cys Leu Thr Ser Leu Thr Gln Asp Arg Gly 
                245                 250                 255     


Gly His Gly Ala Thr Gly Gly Trp Lys Leu Trp Ser Leu Trp Gly Glu 
            260                 265                 270         


Cys Thr Arg Asp Cys Gly Gly Gly Leu Gln Thr Arg Thr Arg Thr Cys 
        275                 280                 285             


Leu Pro Ala Pro Gly Val Glu Gly Gly Gly Cys Glu Gly Val Leu Glu 
    290                 295                 300                 


Glu Gly Arg Gln Cys Asn Arg Glu Ala Cys Gly Pro Ala Gly Arg Thr 
305                 310                 315                 320 


Ser Ser Arg Ser Gln Ser Leu Arg Ser Thr Asp Ala Arg Arg Arg Glu 
                325                 330                 335     


Glu Leu Gly Asp Glu Leu Gln Gln Phe Gly Phe Pro Ala Pro Gln Thr 
            340                 345                 350         


Gly Asp Pro Ala Ala Glu Glu Trp Ser Pro Trp Ser Val Cys Ser Ser 
        355                 360                 365             


Thr Cys Gly Glu Gly Trp Gln Thr Arg Thr Arg Phe Cys Val Ser Ser 
    370                 375                 380                 


Ser Tyr Ser Thr Gln Cys Ser Gly Pro Leu Arg Glu Gln Arg Leu Cys 
385                 390                 395                 400 


Asn Asn Ser Ala Val Cys Pro Val His Gly Ala Trp Asp Glu Trp Ser 
                405                 410                 415     


Pro Trp Ser Leu Cys Ser Ser Thr Cys Gly Arg Gly Phe Arg Asp Arg 
            420                 425                 430         


Thr Arg Thr Cys Arg Pro Pro Gln Phe Gly Gly Asn Pro Cys Glu Gly 
        435                 440                 445             


Pro Glu Lys Gln Thr Lys Phe Cys Asn Ile Ala Leu Cys Pro Gly Arg 
    450                 455                 460                 


Ala Val Asp Gly Asn Trp Asn Glu Trp Ser Ser Trp Ser Ala Cys Ser 
465                 470                 475                 480 


Ala Ser Cys Ser Gln Gly Arg Gln Gln Arg Thr Arg Glu Cys Asn Gly 
                485                 490                 495     


Pro Ser Tyr Gly Gly Ala Glu Cys Gln Gly His Trp Val Glu Thr Arg 
            500                 505                 510         


Asp Cys Phe Leu Gln Gln Cys Pro Val Asp Gly Lys Trp Gln Ala Trp 
        515                 520                 525             


Ala Ser Trp Gly Ser Cys Ser Val Thr Cys Gly Ala Gly Ser Gln Arg 
    530                 535                 540                 


Arg Glu Arg Val Cys Ser Gly Pro Phe Phe Gly Gly Ala Ala Cys Gln 
545                 550                 555                 560 


Gly Pro Gln Asp Glu Tyr Arg Gln Cys Gly Thr Gln Arg Cys Pro Glu 
                565                 570                 575     


Pro His Glu Ile Cys Asp Glu Asp Asn Phe Gly Ala Val Ile Trp Lys 
            580                 585                 590         


Glu Thr Pro Ala Gly Glu Val Ala Ala Val Arg Cys Pro Arg Asn Ala 
        595                 600                 605             


Thr Gly Leu Ile Leu Arg Arg Cys Glu Leu Asp Glu Glu Gly Ile Ala 
    610                 615                 620                 


Tyr Trp Glu Pro Pro Thr Tyr Ile Arg Cys Val Ser Ile Asp Tyr Arg 
625                 630                 635                 640 


Asn Ile Gln Met Met Thr Arg Glu His Leu Ala Lys Ala Gln Arg Gly 
                645                 650                 655     


Leu Pro Gly Glu Gly Val Ser Glu Val Ile Gln Thr Leu Val Glu Ile 
            660                 665                 670         


Ser Gln Asp Gly Thr Ser Tyr Ser Gly Asp Leu Leu Ser Thr Ile Asp 
        675                 680                 685             


Val Leu Arg Asn Met Thr Glu Ile Phe Arg Arg Ala Tyr Tyr Ser Pro 
    690                 695                 700                 


Thr Pro Gly Asp Val Gln Asn Phe Val Gln Ile Leu Ser Asn Leu Leu 
705                 710                 715                 720 


Ala Glu Glu Asn Arg Asp Lys Trp Glu Glu Ala Gln Leu Ala Gly Pro 
                725                 730                 735     


Asn Ala Lys Glu Leu Phe Arg Leu Val Glu Asp Phe Val Asp Val Ile 
            740                 745                 750         


Gly Phe Arg Met Lys Asp Leu Arg Asp Ala Tyr Gln Val Thr Asp Asn 
        755                 760                 765             


Leu Val Leu Ser Ile His Lys Leu Pro Ala Ser Gly Ala Thr Asp Ile 
    770                 775                 780                 


Ser Phe Pro Met Lys Gly Trp Arg Ala Thr Gly Asp Trp Ala Lys Val 
785                 790                 795                 800 


Pro Glu Asp Arg Val Thr Val Ser Lys Ser Val Phe Ser Thr Gly Leu 
                805                 810                 815     


Thr Glu Ala Asp Glu Ala Ser Val Phe Val Val Gly Thr Val Leu Tyr 
            820                 825                 830         


Arg Asn Leu Gly Ser Phe Leu Ala Leu Gln Arg Asn Thr Thr Val Leu 
        835                 840                 845             


Asn Ser Lys Val Ile Ser Val Thr Val Lys Pro Pro Pro Arg Ser Leu 
    850                 855                 860                 


Arg Thr Pro Leu Glu Ile Glu Phe Ala His Met Tyr Asn Gly Thr Thr 
865                 870                 875                 880 


Asn Gln Thr Cys Ile Leu Trp Asp Glu Thr Asp Val Pro Ser Ser Ser 
                885                 890                 895     


Ala Pro Pro Gln Leu Gly Pro Trp Ser Trp Arg Gly Cys Arg Thr Val 
            900                 905                 910         


Pro Leu Asp Ala Leu Arg Thr Arg Cys Leu Cys Asp Arg Leu Ser Thr 
        915                 920                 925             


Phe Ala Ile Leu Ala Gln Leu Ser Ala Asp Ala Asn Met Glu Lys Ala 
    930                 935                 940                 


Thr Leu Pro Ser Val Thr Leu Ile Val Gly Cys Gly Val Ser Ser Leu 
945                 950                 955                 960 


Thr Leu Leu Met Leu Val Ile Ile Tyr Val Ser Val Trp Arg Tyr Ile 
                965                 970                 975     


Arg Ser Glu Arg Ser Val Ile Leu Ile Asn Phe Cys Leu Ser Ile Ile 
            980                 985                 990         


Ser Ser Asn Ala Leu Ile Leu Ile  Gly Gln Thr Gln Thr  Arg Asn Lys 
        995                 1000                 1005             


Val Val  Cys Thr Leu Val Ala  Ala Phe Leu His Phe  Phe Phe Leu 
    1010                 1015                 1020             


Ser Ser  Phe Cys Trp Val Leu  Thr Glu Ala Trp Gln  Ser Tyr Met 
    1025                 1030                 1035             


Ala Val  Thr Gly His Leu Arg  Asn Arg Leu Ile Arg  Lys Arg Phe 
    1040                 1045                 1050             


Leu Cys  Leu Gly Trp Gly Leu  Pro Ala Leu Val Val  Ala Ile Ser 
    1055                 1060                 1065             


Val Gly  Phe Thr Lys Ala Lys  Gly Tyr Ser Thr Met  Asn Tyr Cys 
    1070                 1075                 1080             


Trp Leu  Ser Leu Glu Gly Gly  Leu Leu Tyr Ala Phe  Val Gly Pro 
    1085                 1090                 1095             


Ala Ala  Ala Val Val Leu Val  Asn Met Val Ile Gly  Ile Leu Val 
    1100                 1105                 1110             


Phe Asn  Lys Leu Val Ser Lys  Asp Gly Ile Thr Asp  Lys Lys Leu 
    1115                 1120                 1125             


Lys Glu  Arg Ala Gly Ala Ser  Leu Trp Ser Ser Cys  Val Val Leu 
    1130                 1135                 1140             


Pro Leu  Leu Ala Leu Thr Trp  Met Ser Ala Val Leu  Ala Val Thr 
    1145                 1150                 1155             


Asp Arg  Arg Ser Ala Leu Phe  Gln Ile Leu Phe Ala  Val Phe Asp 
    1160                 1165                 1170             


Ser Leu  Glu Gly Phe Val Ile  Val Met Val His Cys  Ile Leu Arg 
    1175                 1180                 1185             


Arg Glu  Val Gln Asp Ala Val  Lys Cys Arg Val Val  Asp Arg Gln 
    1190                 1195                 1200             


Glu Glu  Gly Asn Gly Asp Ser  Gly Gly Ser Phe Gln  Asn Gly His 
    1205                 1210                 1215             


Ala Gln  Leu Met Thr Asp Phe  Glu Lys Asp Val Asp  Leu Ala Cys 
    1220                 1225                 1230             


Arg Ser  Val Leu Asn Lys Asp  Ile Ala Ala Cys Arg  Thr Ala Thr 
    1235                 1240                 1245             


Ile Thr  Gly Thr Leu Lys Arg  Pro Ser Leu Pro Glu  Glu Glu Lys 
    1250                 1255                 1260             


Leu Lys  Leu Ala His Ala Lys  Gly Pro Pro Thr Asn  Phe Asn Ser 
    1265                 1270                 1275             


Leu Pro  Ala Asn Val Ser Lys  Leu His Leu His Gly  Ser Pro Arg 
    1280                 1285                 1290             


Tyr Pro  Gly Gly Pro Leu Pro  Asp Phe Pro Asn His  Ser Leu Thr 
    1295                 1300                 1305             


Leu Lys  Arg Asp Lys Ala Pro  Lys Ser Ser Phe Val  Gly Asp Gly 
    1310                 1315                 1320             


Asp Ile  Phe Lys Lys Leu Asp  Ser Glu Leu Ser Arg  Ala Gln Glu 
    1325                 1330                 1335             


Lys Ala  Leu Asp Thr Ser Tyr  Val Ile Leu Pro Thr  Ala Thr Ala 
    1340                 1345                 1350             


Thr Leu  Arg Pro Lys Pro Lys  Glu Glu Pro Lys Tyr  Ser Ile His 
    1355                 1360                 1365             


Ile Asp  Gln Met Pro Gln Thr  Arg Leu Ile His Leu  Ser Thr Ala 
    1370                 1375                 1380             


Pro Glu  Ala Ser Leu Pro Ala  Arg Ser Pro Pro Ser  Arg Gln Pro 
    1385                 1390                 1395             


Pro Ser  Gly Gly Pro Pro Glu  Ala Pro Pro Ala Gln  Pro Pro Pro 
    1400                 1405                 1410             


Pro Pro  Pro Pro Pro Pro Pro  Pro Pro Gln Gln Pro  Leu Pro Pro 
    1415                 1420                 1425             


Pro Pro  Asn Leu Glu Pro Ala  Pro Pro Ser Leu Gly  Asp Pro Gly 
    1430                 1435                 1440             


Glu Pro  Ala Ala His Pro Gly  Pro Ser Thr Gly Pro  Ser Thr Lys 
    1445                 1450                 1455             


Asn Glu  Asn Val Ala Thr Leu  Ser Val Ser Ser Leu  Glu Arg Arg 
    1460                 1465                 1470             


Lys Ser  Arg Tyr Ala Glu Leu  Asp Phe Glu Lys Ile  Met His Thr 
    1475                 1480                 1485             


Arg Lys  Arg His Gln Asp Met  Phe Gln Asp Leu Asn  Arg Lys Leu 
    1490                 1495                 1500             


Gln His  Ala Ala Glu Lys Asp  Lys Glu Val Leu Gly  Pro Asp Ser 
    1505                 1510                 1515             


Lys Pro  Glu Lys Gln Gln Thr  Pro Asn Lys Arg Pro  Trp Glu Ser 
    1520                 1525                 1530             


Leu Arg  Lys Ala His Gly Thr  Pro Thr Trp Val Lys  Lys Glu Leu 
    1535                 1540                 1545             


Glu Pro  Leu Gln Pro Ser Pro  Leu Glu Leu Arg Ser  Val Glu Trp 
    1550                 1555                 1560             


Glu Arg  Ser Gly Ala Thr Ile  Pro Leu Val Gly Gln  Asp Ile Ile 
    1565                 1570                 1575             


Asp Leu  Gln Thr Glu Val 
    1580                 


<210>  2
<211>  926
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Gly Gln Ala Ala Ala Pro Gly Pro Val Trp Ile Leu Ala Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Gly Arg Arg Ala Arg Ala Ala Ala 
            20                  25                  30          


Gly Ala Asp Ala Gly Pro Gly Pro Glu Pro Cys Ala Thr Leu Val Gln 
        35                  40                  45              


Gly Lys Phe Phe Gly Tyr Phe Ser Ala Ala Ala Val Phe Pro Ala Asn 
    50                  55                  60                  


Ala Ser Arg Cys Ser Trp Thr Leu Arg Asn Pro Asp Pro Arg Arg Tyr 
65                  70                  75                  80  


Thr Leu Tyr Met Lys Val Ala Lys Ala Pro Val Pro Cys Ser Gly Pro 
                85                  90                  95      


Gly Arg Val Arg Thr Tyr Gln Phe Asp Ser Phe Leu Glu Ser Thr Arg 
            100                 105                 110         


Thr Tyr Leu Gly Val Glu Ser Phe Asp Glu Val Leu Arg Leu Cys Asp 
        115                 120                 125             


Pro Ser Ala Pro Leu Ala Phe Leu Gln Ala Ser Lys Gln Phe Leu Gln 
    130                 135                 140                 


Met Arg Arg Gln Gln Pro Pro Gln His Asp Gly Leu Arg Pro Arg Ala 
145                 150                 155                 160 


Gly Pro Pro Gly Pro Thr Asp Asp Phe Ser Val Glu Tyr Leu Val Val 
                165                 170                 175     


Gly Asn Arg Asn Pro Ser Arg Ala Ala Cys Gln Met Leu Cys Arg Trp 
            180                 185                 190         


Leu Asp Ala Cys Leu Ala Gly Ser Arg Ser Ser His Pro Cys Gly Ile 
        195                 200                 205             


Met Gln Thr Pro Cys Ala Cys Leu Gly Gly Glu Ala Gly Gly Pro Ala 
    210                 215                 220                 


Ala Gly Pro Leu Ala Pro Arg Gly Asp Val Cys Leu Arg Asp Ala Val 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asn Cys Leu Thr Ser Leu Thr Gln Asp Arg Gly 
                245                 250                 255     


Gly His Gly Ala Thr Gly Gly Trp Lys Leu Trp Ser Leu Trp Gly Glu 
            260                 265                 270         


Cys Thr Arg Asp Cys Gly Gly Gly Leu Gln Thr Arg Thr Arg Thr Cys 
        275                 280                 285             


Leu Pro Ala Pro Gly Val Glu Gly Gly Gly Cys Glu Gly Val Leu Glu 
    290                 295                 300                 


Glu Gly Arg Gln Cys Asn Arg Glu Ala Cys Gly Pro Ala Gly Arg Thr 
305                 310                 315                 320 


Ser Ser Arg Ser Gln Ser Leu Arg Ser Thr Asp Ala Arg Arg Arg Glu 
                325                 330                 335     


Glu Leu Gly Asp Glu Leu Gln Gln Phe Gly Phe Pro Ala Pro Gln Thr 
            340                 345                 350         


Gly Asp Pro Ala Ala Glu Glu Trp Ser Pro Trp Ser Val Cys Ser Ser 
        355                 360                 365             


Thr Cys Gly Glu Gly Trp Gln Thr Arg Thr Arg Phe Cys Val Ser Ser 
    370                 375                 380                 


Ser Tyr Ser Thr Gln Cys Ser Gly Pro Leu Arg Glu Gln Arg Leu Cys 
385                 390                 395                 400 


Asn Asn Ser Ala Val Cys Pro Val His Gly Ala Trp Asp Glu Trp Ser 
                405                 410                 415     


Pro Trp Ser Leu Cys Ser Ser Thr Cys Gly Arg Gly Phe Arg Asp Arg 
            420                 425                 430         


Thr Arg Thr Cys Arg Pro Pro Gln Phe Gly Gly Asn Pro Cys Glu Gly 
        435                 440                 445             


Pro Glu Lys Gln Thr Lys Phe Cys Asn Ile Ala Leu Cys Pro Gly Arg 
    450                 455                 460                 


Ala Val Asp Gly Asn Trp Asn Glu Trp Ser Ser Trp Ser Ala Cys Ser 
465                 470                 475                 480 


Ala Ser Cys Ser Gln Gly Arg Gln Gln Arg Thr Arg Glu Cys Asn Gly 
                485                 490                 495     


Pro Ser Tyr Gly Gly Ala Glu Cys Gln Gly His Trp Val Glu Thr Arg 
            500                 505                 510         


Asp Cys Phe Leu Gln Gln Cys Pro Val Asp Gly Lys Trp Gln Ala Trp 
        515                 520                 525             


Ala Ser Trp Gly Ser Cys Ser Val Thr Cys Gly Ala Gly Ser Gln Arg 
    530                 535                 540                 


Arg Glu Arg Val Cys Ser Gly Pro Phe Phe Gly Gly Ala Ala Cys Gln 
545                 550                 555                 560 


Gly Pro Gln Asp Glu Tyr Arg Gln Cys Gly Thr Gln Arg Cys Pro Glu 
                565                 570                 575     


Pro His Glu Ile Cys Asp Glu Asp Asn Phe Gly Ala Val Ile Trp Lys 
            580                 585                 590         


Glu Thr Pro Ala Gly Glu Val Ala Ala Val Arg Cys Pro Arg Asn Ala 
        595                 600                 605             


Thr Gly Leu Ile Leu Arg Arg Cys Glu Leu Asp Glu Glu Gly Ile Ala 
    610                 615                 620                 


Tyr Trp Glu Pro Pro Thr Tyr Ile Arg Cys Val Ser Ile Asp Tyr Arg 
625                 630                 635                 640 


Asn Ile Gln Met Met Thr Arg Glu His Leu Ala Lys Ala Gln Arg Gly 
                645                 650                 655     


Leu Pro Gly Glu Gly Val Ser Glu Val Ile Gln Thr Leu Val Glu Ile 
            660                 665                 670         


Ser Gln Asp Gly Thr Ser Tyr Ser Gly Asp Leu Leu Ser Thr Ile Asp 
        675                 680                 685             


Val Leu Arg Asn Met Thr Glu Ile Phe Arg Arg Ala Tyr Tyr Ser Pro 
    690                 695                 700                 


Thr Pro Gly Asp Val Gln Asn Phe Val Gln Ile Leu Ser Asn Leu Leu 
705                 710                 715                 720 


Ala Glu Glu Asn Arg Asp Lys Trp Glu Glu Ala Gln Leu Ala Gly Pro 
                725                 730                 735     


Asn Ala Lys Glu Leu Phe Arg Leu Val Glu Asp Phe Val Asp Val Ile 
            740                 745                 750         


Gly Phe Arg Met Lys Asp Leu Arg Asp Ala Tyr Gln Val Thr Asp Asn 
        755                 760                 765             


Leu Val Leu Ser Ile His Lys Leu Pro Ala Ser Gly Ala Thr Asp Ile 
    770                 775                 780                 


Ser Phe Pro Met Lys Gly Trp Arg Ala Thr Gly Asp Trp Ala Lys Val 
785                 790                 795                 800 


Pro Glu Asp Arg Val Thr Val Ser Lys Ser Val Phe Ser Thr Gly Leu 
                805                 810                 815     


Thr Glu Ala Asp Glu Ala Ser Val Phe Val Val Gly Thr Val Leu Tyr 
            820                 825                 830         


Arg Asn Leu Gly Ser Phe Leu Ala Leu Gln Arg Asn Thr Thr Val Leu 
        835                 840                 845             


Asn Ser Lys Val Ile Ser Val Thr Val Lys Pro Pro Pro Arg Ser Leu 
    850                 855                 860                 


Arg Thr Pro Leu Glu Ile Glu Phe Ala His Met Tyr Asn Gly Thr Thr 
865                 870                 875                 880 


Asn Gln Thr Cys Ile Leu Trp Asp Glu Thr Asp Val Pro Ser Ser Ser 
                885                 890                 895     


Ala Pro Pro Gln Leu Gly Pro Trp Ser Trp Arg Gly Cys Arg Thr Val 
            900                 905                 910         


Pro Leu Asp Ala Leu Arg Thr Arg Cys Leu Cys Asp Arg Leu 
        915                 920                 925     


<210>  3
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Gly Gln Ala Ala Ala Pro Gly Pro Val Trp Ile Leu Ala Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Gly Arg Arg Ala Arg Ala Ala Ala 
            20                  25                  30          


Gly Ala Asp Ala Gly Pro Gly Pro Glu Pro Cys Ala Thr Leu Val Gln 
        35                  40                  45              


Gly Lys Phe Phe Gly Tyr Phe Ser Ala Ala Ala Val Phe Pro Ala Asn 
    50                  55                  60                  


Ala Ser Arg Cys Ser Trp Thr Leu Arg Asn Pro Asp Pro Arg Arg Tyr 
65                  70                  75                  80  


Thr Leu Tyr Met Lys Val Ala Lys Ala Pro Val Pro Cys Ser Gly Pro 
                85                  90                  95      


Gly Arg Val Arg Thr Tyr Gln Phe Asp Ser Phe Leu Glu Ser Thr Arg 
            100                 105                 110         


Thr Tyr Leu Gly Val Glu Ser Phe Asp Glu Val Leu Arg Leu Cys Asp 
        115                 120                 125             


Pro Ser Ala Pro Leu Ala Phe Leu Gln Ala Ser Lys Gln Phe Leu Gln 
    130                 135                 140                 


Met Arg Arg Gln Gln Pro Pro Gln His Asp Gly Leu Arg Pro Arg Ala 
145                 150                 155                 160 


Gly Pro Pro Gly Pro Thr Asp Asp Phe Ser Val Glu Tyr Leu Val Val 
                165                 170                 175     


Gly Asn Arg Asn Pro Ser Arg Ala Ala Cys Gln Met Leu Cys Arg Trp 
            180                 185                 190         


Leu Asp Ala Cys Leu Ala Gly Ser Arg Ser Ser His Pro Cys Gly Ile 
        195                 200                 205             


Met Gln Thr Pro Cys Ala Cys Leu Gly Gly Glu Ala Gly Gly Pro Ala 
    210                 215                 220                 


Ala Gly Pro Leu Ala Pro Arg Gly Asp Val Cys Leu Arg Asp Ala Val 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asn Cys Leu Thr Ser Leu Thr Gln Asp Arg Gly 
                245                 250                 255     


Gly His Gly Ala Thr Gly Gly Trp Lys Leu Trp Ser Leu Trp Gly Glu 
            260                 265                 270         


Cys Thr Arg Asp Cys Gly Gly Gly Leu Gln Thr Arg Thr Arg Thr Cys 
        275                 280                 285             


Leu Pro Ala Pro Gly Val Glu Gly Gly Gly Cys Glu Gly Val Leu Glu 
    290                 295                 300                 


Glu Gly Arg Gln Cys Asn Arg Glu Ala Cys Gly Pro Ala Gly Arg Thr 
305                 310                 315                 320 


Ser Ser Arg Ser Gln Ser Leu Arg 
                325             


<210>  4
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Ala Asp Ala Gly Pro Gly Pro Glu Pro Cys Ala Thr Leu Val Gln 
1               5                   10                  15      


Gly Lys Phe Phe Gly Tyr Phe Ser Ala Ala Ala Val Phe Pro Ala Asn 
            20                  25                  30          


Ala Ser Arg Cys Ser Trp Thr Leu Arg Asn Pro Asp Pro Arg Arg Tyr 
        35                  40                  45              


Thr Leu Tyr Met Lys Val Ala Lys Ala Pro Val Pro Cys Ser Gly Pro 
    50                  55                  60                  


Gly Arg Val Arg Thr Tyr Gln Phe Asp Ser Phe Leu Glu Ser Thr Arg 
65                  70                  75                  80  


Thr Tyr Leu Gly Val Glu Ser Phe Asp Glu Val Leu Arg Leu Cys Asp 
                85                  90                  95      


Pro Ser Ala Pro Leu Ala Phe Leu Gln Ala Ser Lys Gln Phe Leu Gln 
            100                 105                 110         


Met Arg Arg Gln Gln Pro Pro Gln His Asp Gly Leu Arg Pro Arg Ala 
        115                 120                 125             


Gly Pro Pro Gly Pro Thr Asp Asp Phe Ser Val Glu Tyr Leu Val Val 
    130                 135                 140                 


Gly Asn Arg Asn Pro Ser Arg Ala Ala Cys Gln Met Leu Cys Arg Trp 
145                 150                 155                 160 


Leu Asp Ala Cys Leu Ala Gly Ser Arg Ser Ser His Pro Cys Gly Ile 
                165                 170                 175     


Met Gln Thr Pro Cys Ala Cys Leu Gly Gly Glu Ala Gly Gly Pro Ala 
            180                 185                 190         


Ala Gly Pro Leu Ala Pro Arg Gly Asp Val Cys Leu Arg Asp Ala Val 
        195                 200                 205             


Ala Gly Gly Pro Glu Asn Cys Leu Thr Ser Leu Thr Gln Asp Arg Gly 
    210                 215                 220                 


Gly His Gly Ala Thr Gly Gly Trp Lys Leu Trp Ser Leu Trp Gly Glu 
225                 230                 235                 240 


Cys Thr Arg Asp Cys Gly Gly Gly Leu Gln Thr Arg Thr Arg Thr Cys 
                245                 250                 255     


Leu Pro Ala Pro Gly Val Glu Gly Gly Gly Cys Glu Gly Val Leu Glu 
            260                 265                 270         


Glu Gly Arg Gln Cys Asn Arg Glu Ala Cys Gly Pro Ala Gly Arg Thr 
        275                 280                 285             


Ser Ser Arg Ser Gln Ser Leu Arg Ser Thr Asp Ala Arg Arg Arg Glu 
    290                 295                 300                 


Glu Leu Gly Asp Glu Leu Gln Gln Phe Gly Phe Pro Ala Pro Gln Thr 
305                 310                 315                 320 


Gly Asp Pro Ala Ala Glu Glu Trp Ser Pro Trp Ser Val Cys Ser Ser 
                325                 330                 335     


Thr Cys Gly Glu Gly Trp Gln Thr Arg Thr Arg Phe Cys Val Ser Ser 
            340                 345                 350         


Ser Tyr Ser Thr Gln Cys Ser Gly Pro Leu Arg Glu Gln Arg Leu Cys 
        355                 360                 365             


Asn Asn Ser Ala Val Cys Pro Val His Gly Ala Trp Asp Glu Trp Ser 
    370                 375                 380                 


Pro Trp Ser Leu Cys Ser Ser Thr Cys Gly Arg Gly Phe Arg Asp Arg 
385                 390                 395                 400 


Thr Arg Thr Cys Arg Pro Pro Gln Phe Gly Gly Asn Pro Cys Glu Gly 
                405                 410                 415     


Pro Glu Lys Gln Thr Lys Phe Cys Asn Ile Ala Leu Cys Pro Gly Arg 
            420                 425                 430         


Ala Val Asp Gly Asn Trp Asn Glu Trp Ser Ser Trp Ser Ala Cys Ser 
        435                 440                 445             


Ala Ser Cys Ser Gln Gly Arg Gln Gln Arg Thr Arg Glu Cys Asn Gly 
    450                 455                 460                 


Pro Ser Tyr Gly Gly Ala Glu Cys Gln Gly His Trp Val Glu Thr Arg 
465                 470                 475                 480 


Asp Cys Phe Leu Gln Gln Cys Pro Val Asp Gly Lys Trp Gln Ala Trp 
                485                 490                 495     


Ala Ser Trp Gly Ser Cys Ser Val Thr Cys Gly Ala Gly Ser Gln Arg 
            500                 505                 510         


Arg Glu Arg Val Cys Ser Gly Pro Phe Phe Gly Gly Ala Ala Cys Gln 
        515                 520                 525             


Gly Pro Gln Asp Glu Tyr Arg Gln Cys Gly Thr Gln Arg Cys Pro Glu 
    530                 535                 540                 


Pro His Glu Ile Cys Asp Glu Asp Asn Phe Gly Ala Val Ile Trp Lys 
545                 550                 555                 560 


Glu Thr Pro Ala Gly Glu Val Ala Ala Val Arg Cys Pro Arg Asn Ala 
                565                 570                 575     


Thr Gly Leu Ile Leu Arg Arg Cys Glu Leu Asp Glu Glu Gly Ile Ala 
            580                 585                 590         


Tyr Trp Glu Pro Pro Thr Tyr Ile Arg Cys Val Ser Ile Asp Tyr Arg 
        595                 600                 605             


Asn Ile Gln Met Met Thr Arg Glu His Leu Ala Lys Ala Gln Arg Gly 
    610                 615                 620                 


Leu Pro Gly Glu Gly Val Ser Glu Val Ile Gln Thr Leu Val Glu Ile 
625                 630                 635                 640 


Ser Gln Asp Gly Thr Ser Tyr Ser Gly Asp Leu Leu Ser Thr Ile Asp 
                645                 650                 655     


Val Leu Arg Asn Met Thr Glu Ile Phe Arg Arg Ala Tyr Tyr Ser Pro 
            660                 665                 670         


Thr Pro Gly Asp Val Gln Asn Phe Val Gln Ile Leu Ser Asn Leu Leu 
        675                 680                 685             


Ala Glu Glu Asn Arg Asp Lys Trp Glu Glu Ala Gln Leu Ala Gly Pro 
    690                 695                 700                 


Asn Ala Lys Glu Leu Phe Arg Leu Val Glu Asp Phe Val Asp Val Ile 
705                 710                 715                 720 


Gly Phe Arg Met Lys Asp Leu Arg Asp Ala Tyr Gln Val Thr Asp Asn 
                725                 730                 735     


Leu Val Leu Ser Ile His Lys Leu Pro Ala Ser Gly Ala Thr Asp Ile 
            740                 745                 750         


Ser Phe Pro Met Lys Gly Trp Arg Ala Thr Gly Asp Trp Ala Lys Val 
        755                 760                 765             


Pro Glu Asp Arg Val Thr Val Ser Lys Ser Val Phe Ser Thr Gly Leu 
    770                 775                 780                 


Thr Glu Ala Asp Glu Ala Ser Val Phe Val Val Gly Thr Val Leu Tyr 
785                 790                 795                 800 


Arg Asn Leu Gly Ser Phe Leu Ala Leu Gln Arg Asn Thr Thr Val Leu 
                805                 810                 815     


Asn Ser Lys Val Ile Ser Val Thr Val Lys Pro Pro Pro Arg Ser Leu 
            820                 825                 830         


Arg Thr Pro Leu Glu Ile Glu Phe Ala His Met Tyr Asn Gly Thr Thr 
        835                 840                 845             


Asn Gln Thr Cys Ile Leu Trp Asp Glu Thr Asp Val Pro Ser Ser Ser 
    850                 855                 860                 


Ala Pro Pro Gln Leu Gly Pro Trp Ser Trp Arg Gly Cys Arg Thr Val 
865                 870                 875                 880 


Pro Leu Asp Ala Leu Arg Thr Arg Cys Leu Cys Asp Arg Leu 
                885                 890                 


<210>  5
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Ala Asp Ala Gly Pro Gly Pro Glu Pro Cys Ala Thr Leu Val Gln 
1               5                   10                  15      


Gly Lys Phe Phe Gly Tyr Phe Ser Ala Ala Ala Val Phe Pro Ala Asn 
            20                  25                  30          


Ala Ser Arg Cys Ser Trp Thr Leu Arg Asn Pro Asp Pro Arg Arg Tyr 
        35                  40                  45              


Thr Leu Tyr Met Lys Val Ala Lys Ala Pro Val Pro Cys Ser Gly Pro 
    50                  55                  60                  


Gly Arg Val Arg Thr Tyr Gln Phe Asp Ser Phe Leu Glu Ser Thr Arg 
65                  70                  75                  80  


Thr Tyr Leu Gly Val Glu Ser Phe Asp Glu Val Leu Arg Leu Cys Asp 
                85                  90                  95      


Pro Ser Ala Pro Leu Ala Phe Leu Gln Ala Ser Lys Gln Phe Leu Gln 
            100                 105                 110         


Met Arg Arg Gln Gln Pro Pro Gln His Asp Gly Leu Arg Pro Arg Ala 
        115                 120                 125             


Gly Pro Pro Gly Pro Thr Asp Asp Phe Ser Val Glu Tyr Leu Val Val 
    130                 135                 140                 


Gly Asn Arg Asn Pro Ser Arg Ala Ala Cys Gln Met Leu Cys Arg Trp 
145                 150                 155                 160 


Leu Asp Ala Cys Leu Ala Gly Ser Arg Ser Ser His Pro Cys Gly Ile 
                165                 170                 175     


Met Gln Thr Pro Cys Ala Cys Leu Gly Gly Glu Ala Gly Gly Pro Ala 
            180                 185                 190         


Ala Gly Pro Leu Ala Pro Arg Gly Asp Val Cys Leu Arg Asp Ala Val 
        195                 200                 205             


Ala Gly Gly Pro Glu Asn Cys Leu Thr Ser Leu Thr Gln Asp Arg Gly 
    210                 215                 220                 


Gly His Gly Ala Thr Gly Gly Trp Lys Leu Trp Ser Leu Trp Gly Glu 
225                 230                 235                 240 


Cys Thr Arg Asp Cys Gly Gly Gly Leu Gln Thr Arg Thr Arg Thr Cys 
                245                 250                 255     


Leu Pro Ala Pro Gly Val Glu Gly Gly Gly Cys Glu Gly Val Leu Glu 
            260                 265                 270         


Glu Gly Arg Gln Cys Asn Arg Glu Ala Cys Gly Pro Ala Gly Arg Thr 
        275                 280                 285             


Ser Ser Arg Ser Gln Ser Leu Arg 
    290                 295     


