                         SEQUENCE LISTING

<110>  Oregon Health and Science University
       The Scripps Research Institute	
       McCarty, Owen J.T.
       Gruber, Andras
       Griffin, John H.
 
<120>  HEMOSTATIC AGENTS

<130>  899-78996-02

<150>  US 60/944,693
<151>  2007-06-18

<160>  18    

<170>  PatentIn version 3.3

<210>  1
<211>  1776
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (74)..(1459)

<400>  1
gctgtcatgg cggcaggacg gcgaacttgc agtatctcca cgacccgccc ctacaggtgc     60

cagtgcctcc aga atg tgg cag ctc aca agc ctc ctg ctg ttc gtg gcc       109
               Met Trp Gln Leu Thr Ser Leu Leu Leu Phe Val Ala          
               1               5                   10                   

acc tgg gga att tcc ggc aca cca gct cct ctt gac tca gtg ttc tcc      157
Thr Trp Gly Ile Ser Gly Thr Pro Ala Pro Leu Asp Ser Val Phe Ser         
        15                  20                  25                      

agc agc gag cgt gcc cac cag gtg ctg cgg atc cgc aaa cgt gcc aac      205
Ser Ser Glu Arg Ala His Gln Val Leu Arg Ile Arg Lys Arg Ala Asn         
    30                  35                  40                          

tcc ttc ctg gag gag ctc cgt cac agc agc ctg gag cgg gag tgc ata      253
Ser Phe Leu Glu Glu Leu Arg His Ser Ser Leu Glu Arg Glu Cys Ile         
45                  50                  55                  60          

gag gag atc tgt gac ttc gag gag gcc aag gaa att ttc caa aat gtg      301
Glu Glu Ile Cys Asp Phe Glu Glu Ala Lys Glu Ile Phe Gln Asn Val         
                65                  70                  75              

gat gac aca ctg gcc ttc tgg tcc aag cac gtc gac ggt gac cag tgc      349
Asp Asp Thr Leu Ala Phe Trp Ser Lys His Val Asp Gly Asp Gln Cys         
            80                  85                  90                  

ttg gtc ttg ccc ttg gag cac ccg tgc gcc agc ctg tgc tgc ggg cac      397
Leu Val Leu Pro Leu Glu His Pro Cys Ala Ser Leu Cys Cys Gly His         
        95                  100                 105                     

ggc acg tgc atc gac ggc atc ggc agc ttc agc tgc gac tgc cgc agc      445
Gly Thr Cys Ile Asp Gly Ile Gly Ser Phe Ser Cys Asp Cys Arg Ser         
    110                 115                 120                         

ggc tgg gag ggc cgc ttc tgc cag cgc gag gtg agc ttc ctc aat tgc      493
Gly Trp Glu Gly Arg Phe Cys Gln Arg Glu Val Ser Phe Leu Asn Cys         
125                 130                 135                 140         

tcg ctg gac aac ggc ggc tgc acg cat tac tgc cta gag gag gtg ggc      541
Ser Leu Asp Asn Gly Gly Cys Thr His Tyr Cys Leu Glu Glu Val Gly         
                145                 150                 155             

tgg cgg cgc tgt agc tgt gcg cct ggc tac aag ctg ggg gac gac ctc      589
Trp Arg Arg Cys Ser Cys Ala Pro Gly Tyr Lys Leu Gly Asp Asp Leu         
            160                 165                 170                 

ctg cag tgt cac ccc gca gtg aag ttc cct tgt ggg agg ccc tgg aag      637
Leu Gln Cys His Pro Ala Val Lys Phe Pro Cys Gly Arg Pro Trp Lys         
        175                 180                 185                     

cgg atg gag aag aag cgc agt cac ctg aaa cga gac aca gaa gac caa      685
Arg Met Glu Lys Lys Arg Ser His Leu Lys Arg Asp Thr Glu Asp Gln         
    190                 195                 200                         

gaa gac caa gta gat ccg cgg ctc att gat ggg aag atg acc agg cgg      733
Glu Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys Met Thr Arg Arg         
205                 210                 215                 220         

gga gac agc ccc tgg cag gtg gtc ctg ctg gac tca aag aag aag ctg      781
Gly Asp Ser Pro Trp Gln Val Val Leu Leu Asp Ser Lys Lys Lys Leu         
                225                 230                 235             

gcc tgc ggg gca gtg ctc atc cac ccc tcc tgg gtg ctg aca gcg gcc      829
Ala Cys Gly Ala Val Leu Ile His Pro Ser Trp Val Leu Thr Ala Ala         
            240                 245                 250                 

cac tgc atg gat gag tcc aag aag ctc ctt gtc agg ctt gga gag tat      877
His Cys Met Asp Glu Ser Lys Lys Leu Leu Val Arg Leu Gly Glu Tyr         
        255                 260                 265                     

gac ctg cgg cgc tgg gag aag tgg gag ctg gac ctg gac atc aag gag      925
Asp Leu Arg Arg Trp Glu Lys Trp Glu Leu Asp Leu Asp Ile Lys Glu         
    270                 275                 280                         

gtc ttc gtc cac ccc aac tac agc aag agc acc acc gac aat gac atc      973
Val Phe Val His Pro Asn Tyr Ser Lys Ser Thr Thr Asp Asn Asp Ile         
285                 290                 295                 300         

gca ctg ctg cac ctg gcc cag ccc gcc acc ctc tcg cag acc ata gtg     1021
Ala Leu Leu His Leu Ala Gln Pro Ala Thr Leu Ser Gln Thr Ile Val         
                305                 310                 315             

ccc atc tgc ctc ccg gac agc ggc ctt gca gag cgc gag ctc aat cag     1069
Pro Ile Cys Leu Pro Asp Ser Gly Leu Ala Glu Arg Glu Leu Asn Gln         
            320                 325                 330                 

gcc ggc cag gag acc ctc gtg acg ggc tgg ggc tac cac agc agc cga     1117
Ala Gly Gln Glu Thr Leu Val Thr Gly Trp Gly Tyr His Ser Ser Arg         
        335                 340                 345                     

gag aag gag gcc aag aga aac cgc acc ttc gtc ctc aac ttc atc aag     1165
Glu Lys Glu Ala Lys Arg Asn Arg Thr Phe Val Leu Asn Phe Ile Lys         
    350                 355                 360                         

att ccc gtg gtc ccg cac aat gag tgc agc gag gtc atg agc aac atg     1213
Ile Pro Val Val Pro His Asn Glu Cys Ser Glu Val Met Ser Asn Met         
365                 370                 375                 380         

gtg tct gag aac atg ctg tgt gcg ggc atc ctc ggg gac cgg cag gat     1261
Val Ser Glu Asn Met Leu Cys Ala Gly Ile Leu Gly Asp Arg Gln Asp         
                385                 390                 395             

gcc tgc gag ggc gac agt ggg ggg ccc atg gtc gcc tcc ttc cac ggc     1309
Ala Cys Glu Gly Asp Ser Gly Gly Pro Met Val Ala Ser Phe His Gly         
            400                 405                 410                 

acc tgg ttc ctg gtg ggc ctg gtg agc tgg ggt gag ggc tgt ggg ctc     1357
Thr Trp Phe Leu Val Gly Leu Val Ser Trp Gly Glu Gly Cys Gly Leu         
        415                 420                 425                     

ctt cac aac tac ggc gtt tac acc aaa gtc agc cgc tac ctc gac tgg     1405
Leu His Asn Tyr Gly Val Tyr Thr Lys Val Ser Arg Tyr Leu Asp Trp         
    430                 435                 440                         

atc cat ggg cac atc aga gac aag gaa gcc ccc cag aag agc tgg gca     1453
Ile His Gly His Ile Arg Asp Lys Glu Ala Pro Gln Lys Ser Trp Ala         
445                 450                 455                 460         

cct tag cgaccctccc tgcagggctg ggcttttgca tggcaatgga tgggacatta      1509
Pro                                                                     
                                                                        

aagggacatg taacaagcac accggcctgc tgttctgtcc ttccatccct cttttgggct   1569

cttctggagg gaagtaacat ttactgagca cctgttgtat gtcacatgcc ttatgaatag   1629

aatcttaact cctagagcaa ctctgtgggg tggggaggag cagatccaag ttttgcgggg   1689

tctaaagctg tgtgtgttga gggggatact ctgtttatga aaaagaataa aaaacacaac   1749

cacgaaaaaa aaaaaaaaaa aaaaaaa                                       1776


<210>  2
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Trp Gln Leu Thr Ser Leu Leu Leu Phe Val Ala Thr Trp Gly Ile 
1               5                   10                  15      


Ser Gly Thr Pro Ala Pro Leu Asp Ser Val Phe Ser Ser Ser Glu Arg 
            20                  25                  30          


Ala His Gln Val Leu Arg Ile Arg Lys Arg Ala Asn Ser Phe Leu Glu 
        35                  40                  45              


Glu Leu Arg His Ser Ser Leu Glu Arg Glu Cys Ile Glu Glu Ile Cys 
    50                  55                  60                  


Asp Phe Glu Glu Ala Lys Glu Ile Phe Gln Asn Val Asp Asp Thr Leu 
65                  70                  75                  80  


Ala Phe Trp Ser Lys His Val Asp Gly Asp Gln Cys Leu Val Leu Pro 
                85                  90                  95      


Leu Glu His Pro Cys Ala Ser Leu Cys Cys Gly His Gly Thr Cys Ile 
            100                 105                 110         


Asp Gly Ile Gly Ser Phe Ser Cys Asp Cys Arg Ser Gly Trp Glu Gly 
        115                 120                 125             


Arg Phe Cys Gln Arg Glu Val Ser Phe Leu Asn Cys Ser Leu Asp Asn 
    130                 135                 140                 


Gly Gly Cys Thr His Tyr Cys Leu Glu Glu Val Gly Trp Arg Arg Cys 
145                 150                 155                 160 


Ser Cys Ala Pro Gly Tyr Lys Leu Gly Asp Asp Leu Leu Gln Cys His 
                165                 170                 175     


Pro Ala Val Lys Phe Pro Cys Gly Arg Pro Trp Lys Arg Met Glu Lys 
            180                 185                 190         


Lys Arg Ser His Leu Lys Arg Asp Thr Glu Asp Gln Glu Asp Gln Val 
        195                 200                 205             


Asp Pro Arg Leu Ile Asp Gly Lys Met Thr Arg Arg Gly Asp Ser Pro 
    210                 215                 220                 


Trp Gln Val Val Leu Leu Asp Ser Lys Lys Lys Leu Ala Cys Gly Ala 
225                 230                 235                 240 


Val Leu Ile His Pro Ser Trp Val Leu Thr Ala Ala His Cys Met Asp 
                245                 250                 255     


Glu Ser Lys Lys Leu Leu Val Arg Leu Gly Glu Tyr Asp Leu Arg Arg 
            260                 265                 270         


Trp Glu Lys Trp Glu Leu Asp Leu Asp Ile Lys Glu Val Phe Val His 
        275                 280                 285             


Pro Asn Tyr Ser Lys Ser Thr Thr Asp Asn Asp Ile Ala Leu Leu His 
    290                 295                 300                 


Leu Ala Gln Pro Ala Thr Leu Ser Gln Thr Ile Val Pro Ile Cys Leu 
305                 310                 315                 320 


Pro Asp Ser Gly Leu Ala Glu Arg Glu Leu Asn Gln Ala Gly Gln Glu 
                325                 330                 335     


Thr Leu Val Thr Gly Trp Gly Tyr His Ser Ser Arg Glu Lys Glu Ala 
            340                 345                 350         


Lys Arg Asn Arg Thr Phe Val Leu Asn Phe Ile Lys Ile Pro Val Val 
        355                 360                 365             


Pro His Asn Glu Cys Ser Glu Val Met Ser Asn Met Val Ser Glu Asn 
    370                 375                 380                 


Met Leu Cys Ala Gly Ile Leu Gly Asp Arg Gln Asp Ala Cys Glu Gly 
385                 390                 395                 400 


Asp Ser Gly Gly Pro Met Val Ala Ser Phe His Gly Thr Trp Phe Leu 
                405                 410                 415     


Val Gly Leu Val Ser Trp Gly Glu Gly Cys Gly Leu Leu His Asn Tyr 
            420                 425                 430         


Gly Val Tyr Thr Lys Val Ser Arg Tyr Leu Asp Trp Ile His Gly His 
        435                 440                 445             


Ile Arg Asp Lys Glu Ala Pro Gln Lys Ser Trp Ala Pro 
    450                 455                 460     


<210>  3
<211>  1792
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (56)..(1441)

<400>  3
cggcgaactt gcagtatctc cacgacccgc ccctacaggt gccagtgcct ccaga atg      58
                                                             Met        
                                                             1          

tgg cag ctc aca agc ctc ctg ctg ttc gtg gcc acc tgg gga att tcc      106
Trp Gln Leu Thr Ser Leu Leu Leu Phe Val Ala Thr Trp Gly Ile Ser         
            5                   10                  15                  

ggc aca cca gct cct ctt gac tca gtg ttc tcc agc agc gag cgt gcc      154
Gly Thr Pro Ala Pro Leu Asp Ser Val Phe Ser Ser Ser Glu Arg Ala         
        20                  25                  30                      

cac cag gtg ctg cgg atc cgc aaa cgt gcc aac tcc ttc ctg gag gag      202
His Gln Val Leu Arg Ile Arg Lys Arg Ala Asn Ser Phe Leu Glu Glu         
    35                  40                  45                          

ctc cgt cac agc agc ctg gag cgg gag tgc ata gag gag atc tgt gac      250
Leu Arg His Ser Ser Leu Glu Arg Glu Cys Ile Glu Glu Ile Cys Asp         
50                  55                  60                  65          

ttc gag gag gcc aag gaa att ttc caa aat gtg gat gac aca ctg gcc      298
Phe Glu Glu Ala Lys Glu Ile Phe Gln Asn Val Asp Asp Thr Leu Ala         
                70                  75                  80              

ttc tgg tcc aag cac gtc gac ggt gac cag tgc ttg gtc ttg ccc ttg      346
Phe Trp Ser Lys His Val Asp Gly Asp Gln Cys Leu Val Leu Pro Leu         
            85                  90                  95                  

gag cac ccg tgc gcc agc ctg tgc tgc ggg cac ggc acg tgc atc gac      394
Glu His Pro Cys Ala Ser Leu Cys Cys Gly His Gly Thr Cys Ile Asp         
        100                 105                 110                     

ggc atc ggc agc ttc agc tgc gac tgc cgc agc ggc tgg gag ggc cgc      442
Gly Ile Gly Ser Phe Ser Cys Asp Cys Arg Ser Gly Trp Glu Gly Arg         
    115                 120                 125                         

ttc tgc cag cgc gag gtg agc ttc ctc aat tgc tct ctg gac aac ggc      490
Phe Cys Gln Arg Glu Val Ser Phe Leu Asn Cys Ser Leu Asp Asn Gly         
130                 135                 140                 145         

ggc tgc acg cat tac tgc cta gag gag gtg ggc tgg cgg cgc tgt agc      538
Gly Cys Thr His Tyr Cys Leu Glu Glu Val Gly Trp Arg Arg Cys Ser         
                150                 155                 160             

tgt gcg cct ggc tac aag ctg ggg gac gac ctc ctg cag tgt cac ccc      586
Cys Ala Pro Gly Tyr Lys Leu Gly Asp Asp Leu Leu Gln Cys His Pro         
            165                 170                 175                 

gca gtg aag ttc cct tgt ggg agg ccc tgg aag cgg atg gag aag aag      634
Ala Val Lys Phe Pro Cys Gly Arg Pro Trp Lys Arg Met Glu Lys Lys         
        180                 185                 190                     

cgc agt cac ctg aaa cga gac aca gaa gac caa gaa gac caa gta gat      682
Arg Ser His Leu Lys Arg Asp Thr Glu Asp Gln Glu Asp Gln Val Asp         
    195                 200                 205                         

ccg cgg ctc att gat ggg aag atg acc agg cgg gga gac agc ccc tgg      730
Pro Arg Leu Ile Asp Gly Lys Met Thr Arg Arg Gly Asp Ser Pro Trp         
210                 215                 220                 225         

cag gtg gtc ctg ctg gac tca aag aag aag ctg gcc tgc ggg gca gtg      778
Gln Val Val Leu Leu Asp Ser Lys Lys Lys Leu Ala Cys Gly Ala Val         
                230                 235                 240             

ctc atc cac ccc tcc tgg gtg ctg aca gcg gcc cac tgc atg gat gag      826
Leu Ile His Pro Ser Trp Val Leu Thr Ala Ala His Cys Met Asp Glu         
            245                 250                 255                 

tcc aag aag ctc ctt gtc agg ctt gga gag tat gac ctg cgg cgc tgg      874
Ser Lys Lys Leu Leu Val Arg Leu Gly Glu Tyr Asp Leu Arg Arg Trp         
        260                 265                 270                     

gag aag tgg gag ctg gac ctg gac atc aag gag gtc ttc gtc cac ccc      922
Glu Lys Trp Glu Leu Asp Leu Asp Ile Lys Glu Val Phe Val His Pro         
    275                 280                 285                         

aac tac agc aag agc acc acc gac aat gac atc gca ctg ctg cac ctg      970
Asn Tyr Ser Lys Ser Thr Thr Asp Asn Asp Ile Ala Leu Leu His Leu         
290                 295                 300                 305         

gcc cag ccc gcc acc ctc tcg cag acc ata gtg ccc atc tgc ctc ccg     1018
Ala Gln Pro Ala Thr Leu Ser Gln Thr Ile Val Pro Ile Cys Leu Pro         
                310                 315                 320             

gac agc ggc ctt gca gag cgc gag ctc aat cag gcc ggc cag gag acc     1066
Asp Ser Gly Leu Ala Glu Arg Glu Leu Asn Gln Ala Gly Gln Glu Thr         
            325                 330                 335                 

ctc gtg acg ggc tgg ggc tac cac agc agc cga gag aag gag gcc aag     1114
Leu Val Thr Gly Trp Gly Tyr His Ser Ser Arg Glu Lys Glu Ala Lys         
        340                 345                 350                     

aga aac cgc acc ttc gtc ctc aac ttc atc aag att ccc gtg gtc ccg     1162
Arg Asn Arg Thr Phe Val Leu Asn Phe Ile Lys Ile Pro Val Val Pro         
    355                 360                 365                         

cac aat gag tgc agc gag gtc atg agc aac atg gtg tct gag aac atg     1210
His Asn Glu Cys Ser Glu Val Met Ser Asn Met Val Ser Glu Asn Met         
370                 375                 380                 385         

ctg tgt gcg ggc atc ctc ggg gac cgg cag gat gcc tgc gag ggc gac     1258
Leu Cys Ala Gly Ile Leu Gly Asp Arg Gln Asp Ala Cys Glu Gly Asp         
                390                 395                 400             

agt ggg ggg ccc atg gtc gcc tcc ttc cac ggc acc tgg ttc ctg gtg     1306
Ser Gly Gly Pro Met Val Ala Ser Phe His Gly Thr Trp Phe Leu Val         
            405                 410                 415                 

ggc ctg gtg agc tgg ggt gag ggc tgt ggg ctc ctt cac aac tac ggc     1354
Gly Leu Val Ser Trp Gly Glu Gly Cys Gly Leu Leu His Asn Tyr Gly         
        420                 425                 430                     

gtt tac acc aaa gtc agc cgc tac ctc gac tgg atc cat ggg cac atc     1402
Val Tyr Thr Lys Val Ser Arg Tyr Leu Asp Trp Ile His Gly His Ile         
    435                 440                 445                         

aga gac aag gaa gcc ccc cag aag agc tgg gca cct tag cgaccctccc      1451
Arg Asp Lys Glu Ala Pro Gln Lys Ser Trp Ala Pro                         
450                 455                 460                             

tgcagggctg ggcttttgca tggcaatgga tgggacatta aagggacatg taacaagcac   1511

accggcctgc tgttctgtcc ttccatccct cttttgggct cttctggagg gaagtaacat   1571

ttactgagca cctgttgtat gtcacatgcc ttatgaatag aatcttaact cctagagcaa   1631

ctctgtgggg tggggaggag cagatccaag ttttgcgggg tctaaagctg tgtgtgttga   1691

gggggatact ctgtttatga aaaagaataa aaaacacaac cacgaaaaaa aaaaaaaaaa   1751

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                       1792


<210>  4
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Trp Gln Leu Thr Ser Leu Leu Leu Phe Val Ala Thr Trp Gly Ile 
1               5                   10                  15      


Ser Gly Thr Pro Ala Pro Leu Asp Ser Val Phe Ser Ser Ser Glu Arg 
            20                  25                  30          


Ala His Gln Val Leu Arg Ile Arg Lys Arg Ala Asn Ser Phe Leu Glu 
        35                  40                  45              


Glu Leu Arg His Ser Ser Leu Glu Arg Glu Cys Ile Glu Glu Ile Cys 
    50                  55                  60                  


Asp Phe Glu Glu Ala Lys Glu Ile Phe Gln Asn Val Asp Asp Thr Leu 
65                  70                  75                  80  


Ala Phe Trp Ser Lys His Val Asp Gly Asp Gln Cys Leu Val Leu Pro 
                85                  90                  95      


Leu Glu His Pro Cys Ala Ser Leu Cys Cys Gly His Gly Thr Cys Ile 
            100                 105                 110         


Asp Gly Ile Gly Ser Phe Ser Cys Asp Cys Arg Ser Gly Trp Glu Gly 
        115                 120                 125             


Arg Phe Cys Gln Arg Glu Val Ser Phe Leu Asn Cys Ser Leu Asp Asn 
    130                 135                 140                 


Gly Gly Cys Thr His Tyr Cys Leu Glu Glu Val Gly Trp Arg Arg Cys 
145                 150                 155                 160 


Ser Cys Ala Pro Gly Tyr Lys Leu Gly Asp Asp Leu Leu Gln Cys His 
                165                 170                 175     


Pro Ala Val Lys Phe Pro Cys Gly Arg Pro Trp Lys Arg Met Glu Lys 
            180                 185                 190         


Lys Arg Ser His Leu Lys Arg Asp Thr Glu Asp Gln Glu Asp Gln Val 
        195                 200                 205             


Asp Pro Arg Leu Ile Asp Gly Lys Met Thr Arg Arg Gly Asp Ser Pro 
    210                 215                 220                 


Trp Gln Val Val Leu Leu Asp Ser Lys Lys Lys Leu Ala Cys Gly Ala 
225                 230                 235                 240 


Val Leu Ile His Pro Ser Trp Val Leu Thr Ala Ala His Cys Met Asp 
                245                 250                 255     


Glu Ser Lys Lys Leu Leu Val Arg Leu Gly Glu Tyr Asp Leu Arg Arg 
            260                 265                 270         


Trp Glu Lys Trp Glu Leu Asp Leu Asp Ile Lys Glu Val Phe Val His 
        275                 280                 285             


Pro Asn Tyr Ser Lys Ser Thr Thr Asp Asn Asp Ile Ala Leu Leu His 
    290                 295                 300                 


Leu Ala Gln Pro Ala Thr Leu Ser Gln Thr Ile Val Pro Ile Cys Leu 
305                 310                 315                 320 


Pro Asp Ser Gly Leu Ala Glu Arg Glu Leu Asn Gln Ala Gly Gln Glu 
                325                 330                 335     


Thr Leu Val Thr Gly Trp Gly Tyr His Ser Ser Arg Glu Lys Glu Ala 
            340                 345                 350         


Lys Arg Asn Arg Thr Phe Val Leu Asn Phe Ile Lys Ile Pro Val Val 
        355                 360                 365             


Pro His Asn Glu Cys Ser Glu Val Met Ser Asn Met Val Ser Glu Asn 
    370                 375                 380                 


Met Leu Cys Ala Gly Ile Leu Gly Asp Arg Gln Asp Ala Cys Glu Gly 
385                 390                 395                 400 


Asp Ser Gly Gly Pro Met Val Ala Ser Phe His Gly Thr Trp Phe Leu 
                405                 410                 415     


Val Gly Leu Val Ser Trp Gly Glu Gly Cys Gly Leu Leu His Asn Tyr 
            420                 425                 430         


Gly Val Tyr Thr Lys Val Ser Arg Tyr Leu Asp Trp Ile His Gly His 
        435                 440                 445             


Ile Arg Asp Lys Glu Ala Pro Gln Lys Ser Trp Ala Pro 
    450                 455                 460     


<210>  5
<211>  1366
<212>  DNA
<213>  Homo sapiens

<400>  5
ccaagggcac ggcacgtgca tcgacggcat cggcagcttc agctgcgact gccgcagcgg     60

ctgggagggc cgcttctgcc agcgcgaggt gagcttcctc aattgctctc tggacaacgg    120

cggctgcacg cattactgcc tagaggaggt gggctggcgg cgctgtagct gtgcgcctgg    180

ctacaagctg ggggacgacc tcctgcagtg tcaccccgca gtgaagttcc cttgtgggag    240

gccctggaag cggatggaga agaagcgcag tcacctgaaa cgagacacag aagaccaaga    300

agaccaagta gatccgcggc tcattgatgg gaagatgacc aggcggggag acagcccctg    360

gcaggtggtc ctgctggact caaagaagaa gctggcctgc ggggcagtgc tcatccaccc    420

ctcctgggtg ctgacagcgg cccactgcat ggacgagtcc aagaagctcc ttgtcaggct    480

tggagagtat gacctgcggc gctgggagaa gtgggagctg gacctggaca tcaaggaggt    540

cttcgtccac cccaactaca gcaagagcac caccgacaat gacatcgcac tgctgcacct    600

ggcccagccc gccaccctct cgcagaccat agtgcccatc tgcctcccgg acagcggcct    660

tgcagagcgc gagctcaatc aggccggcca ggagaccctc gtgacgggct ggggctacca    720

cagcagccga gagaaggagg ccaagagaaa ccgcaccttc gtcctcaact tcatcaagat    780

tcccgtggtc ccgcacaatg agtgcagcga ggtcatgagc aacatggtgt ctgagaacat    840

gctgtgtgcg ggcatcctcg gggaccggca ggatgcctgc gagggcgaca gtggggggcc    900

catggtcgcc tccttccacg gcacctggtt cctggtgggc ctggtgagct ggggtgaggg    960

ctgtgggctc cttcacaact acggcgttta caccaaagtc agccgctacc tcgactggat   1020

ccatgggcac atcagagaca aggaagcccc ccagaagagc tgggcacctt agcgaccctc   1080

cctgcagggc tgggcttttg catggcaatg gatgggacat taaagggaca tgtaacaagc   1140

acaccggcct gctgttctgt ccttccatcc ctcttttggg ctcttctgga gggaagtaac   1200

atttactgag cacctgttgt atgtcacatg ccttatgaat agaatcttaa ctcctagagc   1260

aactctgtcg ggtggggagg agcagatcca agttttgcgg ggtctaaagc tgtgtgtgtt   1320

gagggggata ctctgtttat gaaaaagaat aaaaaacaca accacg                  1366


<210>  6
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Gly His Gly Thr Cys Ile Asp Gly Ile Gly Ser Phe Ser Cys Asp 
1               5                   10                  15      


Cys Arg Ser Gly Trp Glu Gly Arg Phe Cys Gln Arg Glu Val Ser Phe 
            20                  25                  30          


Leu Asn Cys Ser Leu Asp Asn Gly Gly Cys Thr His Tyr Cys Leu Glu 
        35                  40                  45              


Glu Val Gly Trp Arg Arg Cys Ser Cys Ala Pro Gly Tyr Lys Leu Gly 
    50                  55                  60                  


Asp Asp Leu Leu Gln Cys His Pro Ala Val Lys Phe Pro Cys Gly Arg 
65                  70                  75                  80  


Pro Trp Lys Arg Met Glu Lys Lys Arg Ser His Leu Lys Arg Asp Thr 
                85                  90                  95      


Glu Asp Gln Glu Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys Met 
            100                 105                 110         


Thr Arg Arg Gly Asp Ser Pro Trp Gln Val Val Leu Leu Asp Ser Lys 
        115                 120                 125             


Lys Lys Leu Ala Cys Gly Ala Val Leu Ile His Pro Ser Trp Val Leu 
    130                 135                 140                 


Thr Ala Ala His Cys Met Asp Glu Ser Lys Lys Leu Leu Val Arg Leu 
145                 150                 155                 160 


Gly Glu Tyr Asp Leu Arg Arg Trp Glu Lys Trp Glu Leu Asp Leu Asp 
                165                 170                 175     


Ile Lys Glu Val Phe Val His Pro Asn Tyr Ser Lys Ser Thr Thr Asp 
            180                 185                 190         


Asn Asp Ile Ala Leu Leu His Leu Ala Gln Pro Ala Thr Leu Ser Gln 
        195                 200                 205             


Thr Ile Val Pro Ile Cys Leu Pro Asp Ser Gly Leu Ala Glu Arg Glu 
    210                 215                 220                 


Leu Asn Gln Ala Gly Gln Glu Thr Leu Val Thr Gly Trp Gly Tyr His 
225                 230                 235                 240 


Ser Ser Arg Glu Lys Glu Ala Lys Arg Asn Arg Thr Phe Val Leu Asn 
                245                 250                 255     


Phe Ile Lys Ile Pro Val Val Pro His Asn Glu Cys Ser Glu Val Met 
            260                 265                 270         


Ser Asn Met Val Ser Glu Asn Met Leu Cys Ala Gly Ile Leu Gly Asp 
        275                 280                 285             


Arg Gln Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Met Val Ala Ser 
    290                 295                 300                 


Phe His Gly Thr Trp Phe Leu Val Gly Leu Val Ser Trp Gly Glu Gly 
305                 310                 315                 320 


Cys Gly Leu Leu His Asn Tyr Gly Val Tyr Thr Lys Val Ser Arg Tyr 
                325                 330                 335     


Leu Asp Trp Ile His Gly His Ile Arg Asp Lys Glu Ala Pro Gln Lys 
            340                 345                 350         


Ser Trp Ala Pro 
        355     


<210>  7
<211>  1499
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (11)..(1396)

<400>  7
gagctccagg atg tgg caa ttc aga gtc ttc ctg ctg ctc atg tcc acc        49
           Met Trp Gln Phe Arg Val Phe Leu Leu Leu Met Ser Thr          
           1               5                   10                       

tgg gga ata tct agc ata ccg gcc cat cct gac cca gtg ttc tcc agc       97
Trp Gly Ile Ser Ser Ile Pro Ala His Pro Asp Pro Val Phe Ser Ser         
    15                  20                  25                          

agc gag cat gcc cac cag gtg ctt cgg gtc aga cgt gcc aac agc ttc      145
Ser Glu His Ala His Gln Val Leu Arg Val Arg Arg Ala Asn Ser Phe         
30                  35                  40                  45          

ctg gaa gag atg cgg cca ggc agc ctg gaa cgg gag tgt atg gag gag      193
Leu Glu Glu Met Arg Pro Gly Ser Leu Glu Arg Glu Cys Met Glu Glu         
                50                  55                  60              

atc tgt gac ttc gag gag gcc cag gag att ttc caa aat gtg gaa gac      241
Ile Cys Asp Phe Glu Glu Ala Gln Glu Ile Phe Gln Asn Val Glu Asp         
            65                  70                  75                  

aca ctg gcc ttc tgg atc aag tac ttt gac ggt gac cag tgc tcg gct      289
Thr Leu Ala Phe Trp Ile Lys Tyr Phe Asp Gly Asp Gln Cys Ser Ala         
        80                  85                  90                      

cca ccc ttg gac cac cag tgc gac agc cca tgc tgc ggg cat ggc act      337
Pro Pro Leu Asp His Gln Cys Asp Ser Pro Cys Cys Gly His Gly Thr         
    95                  100                 105                         

tgc atc gac ggc ata ggc agc ttc agc tgc agc tgc gat aag ggc tgg      385
Cys Ile Asp Gly Ile Gly Ser Phe Ser Cys Ser Cys Asp Lys Gly Trp         
110                 115                 120                 125         

gag ggc aag ttc tgt cag cag gag ttg cgc ttc cag gac tgt cgg gtg      433
Glu Gly Lys Phe Cys Gln Gln Glu Leu Arg Phe Gln Asp Cys Arg Val         
                130                 135                 140             

aac aat ggc ggc tgc ttg cac tac tgc ctg gag gag agc aat ggg cgg      481
Asn Asn Gly Gly Cys Leu His Tyr Cys Leu Glu Glu Ser Asn Gly Arg         
            145                 150                 155                 

cgc tgc gct tgt gcc ccg ggc tat gag ctg gca gac gac cac atg cgc      529
Arg Cys Ala Cys Ala Pro Gly Tyr Glu Leu Ala Asp Asp His Met Arg         
        160                 165                 170                     

tgc aag tcc act gtg aat ttt cca tgt ggg aaa ctg ggg agg tgg ata      577
Cys Lys Ser Thr Val Asn Phe Pro Cys Gly Lys Leu Gly Arg Trp Ile         
    175                 180                 185                         

gag aag aaa cgc aag atc ctc aaa cga gac aca gac tta gaa gat gaa      625
Glu Lys Lys Arg Lys Ile Leu Lys Arg Asp Thr Asp Leu Glu Asp Glu         
190                 195                 200                 205         

ctg gaa cca gat cca agg ata gtc aac gga acg ctg acg aag cag ggt      673
Leu Glu Pro Asp Pro Arg Ile Val Asn Gly Thr Leu Thr Lys Gln Gly         
                210                 215                 220             

gac agt cct tgg cag gca atc ctt ctg gac tcc aag aag aag ctg gcc      721
Asp Ser Pro Trp Gln Ala Ile Leu Leu Asp Ser Lys Lys Lys Leu Ala         
            225                 230                 235                 

tgc gga ggg gtg ctc atc cac act tcc tgg gtg ctg acg gca gcc cac      769
Cys Gly Gly Val Leu Ile His Thr Ser Trp Val Leu Thr Ala Ala His         
        240                 245                 250                     

tgc gtg gag ggc acc aag aag ctt acc gtg agg ctt ggt gag tat gat      817
Cys Val Glu Gly Thr Lys Lys Leu Thr Val Arg Leu Gly Glu Tyr Asp         
    255                 260                 265                         

ctg cga cgc agg gac cac tgg gag ctg gac ctg gac atc aag gag atc      865
Leu Arg Arg Arg Asp His Trp Glu Leu Asp Leu Asp Ile Lys Glu Ile         
270                 275                 280                 285         

ctc gtc cac cct aac tac acc cgg agc agc agt gac aac gac att gct      913
Leu Val His Pro Asn Tyr Thr Arg Ser Ser Ser Asp Asn Asp Ile Ala         
                290                 295                 300             

ctg ctc cgc cta gcc cag cca gcc act ctc tcc aaa acc ata gtg ccc      961
Leu Leu Arg Leu Ala Gln Pro Ala Thr Leu Ser Lys Thr Ile Val Pro         
            305                 310                 315                 

atc tgc ctg ccg aac aat ggg ctc gct cag cag gag ctc act cag gct     1009
Ile Cys Leu Pro Asn Asn Gly Leu Ala Gln Gln Glu Leu Thr Gln Ala         
        320                 325                 330                     

ggc cag gag aca gtg gtg aca ggc tgg ggc tat caa agc gac aga atc     1057
Gly Gln Glu Thr Val Val Thr Gly Trp Gly Tyr Gln Ser Asp Arg Ile         
    335                 340                 345                         

aag gat ggc aga agg aac cgc acc ttc atc ctc acc ttc atc cgc atc     1105
Lys Asp Gly Arg Arg Asn Arg Thr Phe Ile Leu Thr Phe Ile Arg Ile         
350                 355                 360                 365         

cct ttg gtt gct cga aat gag tgc gtg gag gtc atg aag aat gtg gtc     1153
Pro Leu Val Ala Arg Asn Glu Cys Val Glu Val Met Lys Asn Val Val         
                370                 375                 380             

tcg gag aac atg ctg tgt gca ggc atc att ggg aac acg aga gac gcc     1201
Ser Glu Asn Met Leu Cys Ala Gly Ile Ile Gly Asn Thr Arg Asp Ala         
            385                 390                 395                 

tgt gat ggt gac agt ggg ggg ccc atg gtg gtc ttc ttt cgg ggt acc     1249
Cys Asp Gly Asp Ser Gly Gly Pro Met Val Val Phe Phe Arg Gly Thr         
        400                 405                 410                     

tgg ttc ctg gtg ggc ctg gtg agc tgg ggt gag ggc tgt ggg cac acc     1297
Trp Phe Leu Val Gly Leu Val Ser Trp Gly Glu Gly Cys Gly His Thr         
    415                 420                 425                         

aac aac tat ggc atc tac acc aaa gtg gga agc tac ctc aaa tgg att     1345
Asn Asn Tyr Gly Ile Tyr Thr Lys Val Gly Ser Tyr Leu Lys Trp Ile         
430                 435                 440                 445         

cac agt tac att ggg gaa aag ggt gtc tcc ctt aag agc cag aag cta     1393
His Ser Tyr Ile Gly Glu Lys Gly Val Ser Leu Lys Ser Gln Lys Leu         
                450                 455                 460             

tag cacccctccc tgctcacctc tggaccctag aagtcactct tggagtaagg          1446

ctgggctagt gagtaccaag acagaggaca ttaaaggagc atgcaacaaa cat          1499


<210>  8
<211>  461
<212>  PRT
<213>  Mus musculus

<400>  8

Met Trp Gln Phe Arg Val Phe Leu Leu Leu Met Ser Thr Trp Gly Ile 
1               5                   10                  15      


Ser Ser Ile Pro Ala His Pro Asp Pro Val Phe Ser Ser Ser Glu His 
            20                  25                  30          


Ala His Gln Val Leu Arg Val Arg Arg Ala Asn Ser Phe Leu Glu Glu 
        35                  40                  45              


Met Arg Pro Gly Ser Leu Glu Arg Glu Cys Met Glu Glu Ile Cys Asp 
    50                  55                  60                  


Phe Glu Glu Ala Gln Glu Ile Phe Gln Asn Val Glu Asp Thr Leu Ala 
65                  70                  75                  80  


Phe Trp Ile Lys Tyr Phe Asp Gly Asp Gln Cys Ser Ala Pro Pro Leu 
                85                  90                  95      


Asp His Gln Cys Asp Ser Pro Cys Cys Gly His Gly Thr Cys Ile Asp 
            100                 105                 110         


Gly Ile Gly Ser Phe Ser Cys Ser Cys Asp Lys Gly Trp Glu Gly Lys 
        115                 120                 125             


Phe Cys Gln Gln Glu Leu Arg Phe Gln Asp Cys Arg Val Asn Asn Gly 
    130                 135                 140                 


Gly Cys Leu His Tyr Cys Leu Glu Glu Ser Asn Gly Arg Arg Cys Ala 
145                 150                 155                 160 


Cys Ala Pro Gly Tyr Glu Leu Ala Asp Asp His Met Arg Cys Lys Ser 
                165                 170                 175     


Thr Val Asn Phe Pro Cys Gly Lys Leu Gly Arg Trp Ile Glu Lys Lys 
            180                 185                 190         


Arg Lys Ile Leu Lys Arg Asp Thr Asp Leu Glu Asp Glu Leu Glu Pro 
        195                 200                 205             


Asp Pro Arg Ile Val Asn Gly Thr Leu Thr Lys Gln Gly Asp Ser Pro 
    210                 215                 220                 


Trp Gln Ala Ile Leu Leu Asp Ser Lys Lys Lys Leu Ala Cys Gly Gly 
225                 230                 235                 240 


Val Leu Ile His Thr Ser Trp Val Leu Thr Ala Ala His Cys Val Glu 
                245                 250                 255     


Gly Thr Lys Lys Leu Thr Val Arg Leu Gly Glu Tyr Asp Leu Arg Arg 
            260                 265                 270         


Arg Asp His Trp Glu Leu Asp Leu Asp Ile Lys Glu Ile Leu Val His 
        275                 280                 285             


Pro Asn Tyr Thr Arg Ser Ser Ser Asp Asn Asp Ile Ala Leu Leu Arg 
    290                 295                 300                 


Leu Ala Gln Pro Ala Thr Leu Ser Lys Thr Ile Val Pro Ile Cys Leu 
305                 310                 315                 320 


Pro Asn Asn Gly Leu Ala Gln Gln Glu Leu Thr Gln Ala Gly Gln Glu 
                325                 330                 335     


Thr Val Val Thr Gly Trp Gly Tyr Gln Ser Asp Arg Ile Lys Asp Gly 
            340                 345                 350         


Arg Arg Asn Arg Thr Phe Ile Leu Thr Phe Ile Arg Ile Pro Leu Val 
        355                 360                 365             


Ala Arg Asn Glu Cys Val Glu Val Met Lys Asn Val Val Ser Glu Asn 
    370                 375                 380                 


Met Leu Cys Ala Gly Ile Ile Gly Asn Thr Arg Asp Ala Cys Asp Gly 
385                 390                 395                 400 


Asp Ser Gly Gly Pro Met Val Val Phe Phe Arg Gly Thr Trp Phe Leu 
                405                 410                 415     


Val Gly Leu Val Ser Trp Gly Glu Gly Cys Gly His Thr Asn Asn Tyr 
            420                 425                 430         


Gly Ile Tyr Thr Lys Val Gly Ser Tyr Leu Lys Trp Ile His Ser Tyr 
        435                 440                 445             


Ile Gly Glu Lys Gly Val Ser Leu Lys Ser Gln Lys Leu 
    450                 455                 460     


<210>  9
<211>  1661
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (163)..(1545)

<400>  9
ggttatggat taacctgact cccagactga catggcgcta cctggacgaa attgcagttt     60

ctccttggcc cacgcctgtg taggcttgtg acaagccgcg tatctcctcc aagcctttgg    120

gtcccttccc atgaaatgga gacaggtgtc agcagctcca gg atg tgg caa ttc       174
                                               Met Trp Gln Phe          
                                               1                        

aga gtc ttc ctg ctg ctc atg tcc acc tgg gga ata tct agc ata ccg      222
Arg Val Phe Leu Leu Leu Met Ser Thr Trp Gly Ile Ser Ser Ile Pro         
5                   10                  15                  20          

gcc cat cct gac cca gtg ttc tcc agc agc gag cat gcc cac cag gtg      270
Ala His Pro Asp Pro Val Phe Ser Ser Ser Glu His Ala His Gln Val         
                25                  30                  35              

ctt cgg gtc aga cgt gcc aac agc ttc ctg gaa gag atg cgg cca ggc      318
Leu Arg Val Arg Arg Ala Asn Ser Phe Leu Glu Glu Met Arg Pro Gly         
            40                  45                  50                  

agc ctg gaa cgg gag tgt atg gag gag atc tgt gac ttc gag gag gcc      366
Ser Leu Glu Arg Glu Cys Met Glu Glu Ile Cys Asp Phe Glu Glu Ala         
        55                  60                  65                      

cag gag att ttc caa aat gtg gaa gac aca ctg gcc ttc tgg atc aag      414
Gln Glu Ile Phe Gln Asn Val Glu Asp Thr Leu Ala Phe Trp Ile Lys         
    70                  75                  80                          

tac ttt gac ggt gac cag tgc tcg gct cca ccc ttg gac cac cag tgc      462
Tyr Phe Asp Gly Asp Gln Cys Ser Ala Pro Pro Leu Asp His Gln Cys         
85                  90                  95                  100         

gac agc cca tgc tgc ggg cat ggc act tgc atc gac ggc ata ggc agc      510
Asp Ser Pro Cys Cys Gly His Gly Thr Cys Ile Asp Gly Ile Gly Ser         
                105                 110                 115             

ttc agc tgc agc tgc gat aag ggc tgg gag ggc aag ttc tgt cag cag      558
Phe Ser Cys Ser Cys Asp Lys Gly Trp Glu Gly Lys Phe Cys Gln Gln         
            120                 125                 130                 

gag ttg cgc ttc cag gac tgt cgg gtg aac aat ggc ggc tgc ttg cac      606
Glu Leu Arg Phe Gln Asp Cys Arg Val Asn Asn Gly Gly Cys Leu His         
        135                 140                 145                     

tac tgc ctg gag gag agc aat ggg cgg cgc tgc gct tgt gcc ccg ggc      654
Tyr Cys Leu Glu Glu Ser Asn Gly Arg Arg Cys Ala Cys Ala Pro Gly         
    150                 155                 160                         

tat gag ctg gca gac gac cac atg cgc tgc aag tcc act gtg aat ttt      702
Tyr Glu Leu Ala Asp Asp His Met Arg Cys Lys Ser Thr Val Asn Phe         
165                 170                 175                 180         

cca tgt ggg aaa ctg ggg agg tgg ata gag aag aaa cgc aag atc ctc      750
Pro Cys Gly Lys Leu Gly Arg Trp Ile Glu Lys Lys Arg Lys Ile Leu         
                185                 190                 195             

aaa cga gac aca gac tta gaa gat gaa ctg gaa cca gat cca agg ata      798
Lys Arg Asp Thr Asp Leu Glu Asp Glu Leu Glu Pro Asp Pro Arg Ile         
            200                 205                 210                 

gtc aac gga acg ctg acg aag cag ggt gac agt cct tgg cag gca atc      846
Val Asn Gly Thr Leu Thr Lys Gln Gly Asp Ser Pro Trp Gln Ala Ile         
        215                 220                 225                     

ctt ctg gac tcc aag aag aag ctg gcc tgc gga ggg gtg ctc atc cac      894
Leu Leu Asp Ser Lys Lys Lys Leu Ala Cys Gly Gly Val Leu Ile His         
    230                 235                 240                         

act tcc tgg gtg ctg acg gca gcc cac tgc gtg gag ggc acc aag aag      942
Thr Ser Trp Val Leu Thr Ala Ala His Cys Val Glu Gly Thr Lys Lys         
245                 250                 255                 260         

ctt acc gtg agg ctt ggt gag tat gat ctg cga cgc agg gac cac tgg      990
Leu Thr Val Arg Leu Gly Glu Tyr Asp Leu Arg Arg Arg Asp His Trp         
                265                 270                 275             

gag ctg gac ctg gac atc aag gag atc ctc gtc cac cct aac tac acc     1038
Glu Leu Asp Leu Asp Ile Lys Glu Ile Leu Val His Pro Asn Tyr Thr         
            280                 285                 290                 

cgg agc agc agt gac aac gac att gct ctg ctc cgc cta gcc cag cca     1086
Arg Ser Ser Ser Asp Asn Asp Ile Ala Leu Leu Arg Leu Ala Gln Pro         
        295                 300                 305                     

gcc act ctc tcc aaa acc ata gtg ccc atc tgc ctg ccg aac aat ggg     1134
Ala Thr Leu Ser Lys Thr Ile Val Pro Ile Cys Leu Pro Asn Asn Gly         
    310                 315                 320                         

ctg gcg cag gag ctc act cag gct ggc cag gag aca gtg gtg aca ggc     1182
Leu Ala Gln Glu Leu Thr Gln Ala Gly Gln Glu Thr Val Val Thr Gly         
325                 330                 335                 340         

tgg ggc tat caa agc gac aga atc aag gat ggc aga agg aac cgc acc     1230
Trp Gly Tyr Gln Ser Asp Arg Ile Lys Asp Gly Arg Arg Asn Arg Thr         
                345                 350                 355             

ttc atc ctc acc ttc atc cgc atc cct ttg gtt gct cga aat gag tgc     1278
Phe Ile Leu Thr Phe Ile Arg Ile Pro Leu Val Ala Arg Asn Glu Cys         
            360                 365                 370                 

gtg gag gtc atg aag aat gtg gtc tcg gag aac atg ctg tgt gca ggc     1326
Val Glu Val Met Lys Asn Val Val Ser Glu Asn Met Leu Cys Ala Gly         
        375                 380                 385                     

atc att ggg gac acg aga gac gcc tgt gat ggt gac agt ggg ggg ccc     1374
Ile Ile Gly Asp Thr Arg Asp Ala Cys Asp Gly Asp Ser Gly Gly Pro         
    390                 395                 400                         

atg gtg gtc ttc ttt cgg ggt acc tgg ttc ctg gtg ggc ctg gtg agc     1422
Met Val Val Phe Phe Arg Gly Thr Trp Phe Leu Val Gly Leu Val Ser         
405                 410                 415                 420         

tgg ggt gag ggc tgt ggg cac acc aac aac tat ggc atc tac acc aaa     1470
Trp Gly Glu Gly Cys Gly His Thr Asn Asn Tyr Gly Ile Tyr Thr Lys         
                425                 430                 435             

gtg gga agc tac ctc aaa tgg att cac agt tac att ggg gaa aag ggt     1518
Val Gly Ser Tyr Leu Lys Trp Ile His Ser Tyr Ile Gly Glu Lys Gly         
            440                 445                 450                 

gtc tcc ctt aag agc cag aag cta tag cacccctccc tgctcacctc           1565
Val Ser Leu Lys Ser Gln Lys Leu                                         
        455                 460                                         

tggaccctag aagtcactct tggagtaagg ctgggctagt gagtaccaag acagaggaca   1625

ttaaaggagc atgcaacaaa cataaaaaaa aaaaaa                             1661


<210>  10
<211>  460
<212>  PRT
<213>  Mus musculus

<400>  10

Met Trp Gln Phe Arg Val Phe Leu Leu Leu Met Ser Thr Trp Gly Ile 
1               5                   10                  15      


Ser Ser Ile Pro Ala His Pro Asp Pro Val Phe Ser Ser Ser Glu His 
            20                  25                  30          


Ala His Gln Val Leu Arg Val Arg Arg Ala Asn Ser Phe Leu Glu Glu 
        35                  40                  45              


Met Arg Pro Gly Ser Leu Glu Arg Glu Cys Met Glu Glu Ile Cys Asp 
    50                  55                  60                  


Phe Glu Glu Ala Gln Glu Ile Phe Gln Asn Val Glu Asp Thr Leu Ala 
65                  70                  75                  80  


Phe Trp Ile Lys Tyr Phe Asp Gly Asp Gln Cys Ser Ala Pro Pro Leu 
                85                  90                  95      


Asp His Gln Cys Asp Ser Pro Cys Cys Gly His Gly Thr Cys Ile Asp 
            100                 105                 110         


Gly Ile Gly Ser Phe Ser Cys Ser Cys Asp Lys Gly Trp Glu Gly Lys 
        115                 120                 125             


Phe Cys Gln Gln Glu Leu Arg Phe Gln Asp Cys Arg Val Asn Asn Gly 
    130                 135                 140                 


Gly Cys Leu His Tyr Cys Leu Glu Glu Ser Asn Gly Arg Arg Cys Ala 
145                 150                 155                 160 


Cys Ala Pro Gly Tyr Glu Leu Ala Asp Asp His Met Arg Cys Lys Ser 
                165                 170                 175     


Thr Val Asn Phe Pro Cys Gly Lys Leu Gly Arg Trp Ile Glu Lys Lys 
            180                 185                 190         


Arg Lys Ile Leu Lys Arg Asp Thr Asp Leu Glu Asp Glu Leu Glu Pro 
        195                 200                 205             


Asp Pro Arg Ile Val Asn Gly Thr Leu Thr Lys Gln Gly Asp Ser Pro 
    210                 215                 220                 


Trp Gln Ala Ile Leu Leu Asp Ser Lys Lys Lys Leu Ala Cys Gly Gly 
225                 230                 235                 240 


Val Leu Ile His Thr Ser Trp Val Leu Thr Ala Ala His Cys Val Glu 
                245                 250                 255     


Gly Thr Lys Lys Leu Thr Val Arg Leu Gly Glu Tyr Asp Leu Arg Arg 
            260                 265                 270         


Arg Asp His Trp Glu Leu Asp Leu Asp Ile Lys Glu Ile Leu Val His 
        275                 280                 285             


Pro Asn Tyr Thr Arg Ser Ser Ser Asp Asn Asp Ile Ala Leu Leu Arg 
    290                 295                 300                 


Leu Ala Gln Pro Ala Thr Leu Ser Lys Thr Ile Val Pro Ile Cys Leu 
305                 310                 315                 320 


Pro Asn Asn Gly Leu Ala Gln Glu Leu Thr Gln Ala Gly Gln Glu Thr 
                325                 330                 335     


Val Val Thr Gly Trp Gly Tyr Gln Ser Asp Arg Ile Lys Asp Gly Arg 
            340                 345                 350         


Arg Asn Arg Thr Phe Ile Leu Thr Phe Ile Arg Ile Pro Leu Val Ala 
        355                 360                 365             


Arg Asn Glu Cys Val Glu Val Met Lys Asn Val Val Ser Glu Asn Met 
    370                 375                 380                 


Leu Cys Ala Gly Ile Ile Gly Asp Thr Arg Asp Ala Cys Asp Gly Asp 
385                 390                 395                 400 


Ser Gly Gly Pro Met Val Val Phe Phe Arg Gly Thr Trp Phe Leu Val 
                405                 410                 415     


Gly Leu Val Ser Trp Gly Glu Gly Cys Gly His Thr Asn Asn Tyr Gly 
            420                 425                 430         


Ile Tyr Thr Lys Val Gly Ser Tyr Leu Lys Trp Ile His Ser Tyr Ile 
        435                 440                 445             


Gly Glu Lys Gly Val Ser Leu Lys Ser Gln Lys Leu 
    450                 455                 460 


<210>  11
<211>  1543
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  CDS
<222>  (49)..(1434)

<400>  11
cgaaattgca gtttctcctt ggcccacccc tgtgtcagca gctccagg atg tgg cag      57
                                                     Met Trp Gln        
                                                     1                  

ttc aga atc ttc ctg ctg ttc gcg tcc acc tgg ggg att tct ggc gta      105
Phe Arg Ile Phe Leu Leu Phe Ala Ser Thr Trp Gly Ile Ser Gly Val         
    5                   10                  15                          

tca gcc cat ccc gac cca gtg ttc tcc agc agc gag ggt gcc cac cag      153
Ser Ala His Pro Asp Pro Val Phe Ser Ser Ser Glu Gly Ala His Gln         
20                  25                  30                  35          

gtg ctt cgg gtc aga cga gcc aac agc ttc ctg gag gag gtg cgg gca      201
Val Leu Arg Val Arg Arg Ala Asn Ser Phe Leu Glu Glu Val Arg Ala         
                40                  45                  50              

ggc agc ctg gag cgg gag tgt atg gag gag atc tgt gac ttc gag gag      249
Gly Ser Leu Glu Arg Glu Cys Met Glu Glu Ile Cys Asp Phe Glu Glu         
            55                  60                  65                  

gcc cag gag att ttc cag aat gtg gaa gac aca ctg gcc ttt tgg atc      297
Ala Gln Glu Ile Phe Gln Asn Val Glu Asp Thr Leu Ala Phe Trp Ile         
        70                  75                  80                      

aag tac ttc gat ggt gac cag tgc tca act ccg ccc ttg gac cac caa      345
Lys Tyr Phe Asp Gly Asp Gln Cys Ser Thr Pro Pro Leu Asp His Gln         
    85                  90                  95                          

tgc gac agc cca tgc tgc ggc cat ggc aca tgc atc gac ggc ctg ggc      393
Cys Asp Ser Pro Cys Cys Gly His Gly Thr Cys Ile Asp Gly Leu Gly         
100                 105                 110                 115         

ggc ttc agc tgc agc tgc gat aag ggc tgg gag ggc agg ttc tgt cag      441
Gly Phe Ser Cys Ser Cys Asp Lys Gly Trp Glu Gly Arg Phe Cys Gln         
                120                 125                 130             

cag gag atg ggc ttc cag gac tgt cgg gtg aaa aat ggc ggc tgc tac      489
Gln Glu Met Gly Phe Gln Asp Cys Arg Val Lys Asn Gly Gly Cys Tyr         
            135                 140                 145                 

cac tac tgc ctg gag gag acc aga ggg cgg cgc tgc cgt tgc gcc ccg      537
His Tyr Cys Leu Glu Glu Thr Arg Gly Arg Arg Cys Arg Cys Ala Pro         
        150                 155                 160                     

ggc tat gag ctg gca gat gac cac atg cac tgc agg ccc acc gtg aat      585
Gly Tyr Glu Leu Ala Asp Asp His Met His Cys Arg Pro Thr Val Asn         
    165                 170                 175                         

ttt ccg tgt ggg aaa ctg tgg aag cgg act gac aag aaa cgc aag aac      633
Phe Pro Cys Gly Lys Leu Trp Lys Arg Thr Asp Lys Lys Arg Lys Asn         
180                 185                 190                 195         

ttc aaa cgg gac ata gac cca gaa gac gaa gaa cta gaa cta ggt cca      681
Phe Lys Arg Asp Ile Asp Pro Glu Asp Glu Glu Leu Glu Leu Gly Pro         
                200                 205                 210             

agg ata gtc aat gga aca cta aca aag cag ggt gac agt ccc tgg cag      729
Arg Ile Val Asn Gly Thr Leu Thr Lys Gln Gly Asp Ser Pro Trp Gln         
            215                 220                 225                 

gcg atc ctt ctg gac tcc aag aag aag cta gcc tgt gga ggg gtg ctc      777
Ala Ile Leu Leu Asp Ser Lys Lys Lys Leu Ala Cys Gly Gly Val Leu         
        230                 235                 240                     

atc cac acc tcc tgg gtg ctg acg gca gcc cac tgt ctg gag agc agc      825
Ile His Thr Ser Trp Val Leu Thr Ala Ala His Cys Leu Glu Ser Ser         
    245                 250                 255                         

aag aag ctt acc gtg agg ctt ggt gag tat gat ctg aga cgc agg gac      873
Lys Lys Leu Thr Val Arg Leu Gly Glu Tyr Asp Leu Arg Arg Arg Asp         
260                 265                 270                 275         

ccc tgg gag ttg gac ctg gac atc aag gag gtc ctc gtc cac cct aac      921
Pro Trp Glu Leu Asp Leu Asp Ile Lys Glu Val Leu Val His Pro Asn         
                280                 285                 290             

tac acc cgg agc aac agc gac aac gac atc gcc ctg ctc cgc ctg tcc      969
Tyr Thr Arg Ser Asn Ser Asp Asn Asp Ile Ala Leu Leu Arg Leu Ser         
            295                 300                 305                 

cag cca gcc aca ctc tct aaa acc ata gtg ccc atc tgt ctg ccg aac     1017
Gln Pro Ala Thr Leu Ser Lys Thr Ile Val Pro Ile Cys Leu Pro Asn         
        310                 315                 320                     

agc ggc ctg gcg cag gag ctc agt cag gct ggc cag gag acg gtg gtg     1065
Ser Gly Leu Ala Gln Glu Leu Ser Gln Ala Gly Gln Glu Thr Val Val         
    325                 330                 335                         

aca ggc tgg ggc tat caa agc gac aaa gtc aag gat ggc aga agg aac     1113
Thr Gly Trp Gly Tyr Gln Ser Asp Lys Val Lys Asp Gly Arg Arg Asn         
340                 345                 350                 355         

cgc acc ttt att ctc acc ttc atc cgc atc cct ttg gcc gct cga aat     1161
Arg Thr Phe Ile Leu Thr Phe Ile Arg Ile Pro Leu Ala Ala Arg Asn         
                360                 365                 370             

gac tgc atg cag gtc atg aac aac gtg gtc tcg gag aac atg ctc tgc     1209
Asp Cys Met Gln Val Met Asn Asn Val Val Ser Glu Asn Met Leu Cys         
            375                 380                 385                 

gcc ggc atc att gga gac acg aga gac gcc tgc gac ggc gac agt ggg     1257
Ala Gly Ile Ile Gly Asp Thr Arg Asp Ala Cys Asp Gly Asp Ser Gly         
        390                 395                 400                     

gga cct atg gtg gtc ttc ttt cgg ggt acc tgg ttt ctg gtg ggc ctg     1305
Gly Pro Met Val Val Phe Phe Arg Gly Thr Trp Phe Leu Val Gly Leu         
    405                 410                 415                         

gtg agc tgg ggt gag ggc tgt ggg cac ctc aac aac tat ggc gtc tac     1353
Val Ser Trp Gly Glu Gly Cys Gly His Leu Asn Asn Tyr Gly Val Tyr         
420                 425                 430                 435         

acc aaa gtg ggt agc tac ctc aaa tgg atc cac agc tac ata ggg gaa     1401
Thr Lys Val Gly Ser Tyr Leu Lys Trp Ile His Ser Tyr Ile Gly Glu         
                440                 445                 450             

agg gat gtt tcc ctg aag agc ccg aag ctg tag catccctccc tgctcatctc   1454
Arg Asp Val Ser Leu Lys Ser Pro Lys Leu                                 
            455                 460                                     

tggggcccag aggtcactct tagaataagg ctgggctagt gagtaccaag acaggggaca   1514

ttaaaggggc aagcaacacc tgaaaaaaa                                     1543


<210>  12
<211>  461
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Met Trp Gln Phe Arg Ile Phe Leu Leu Phe Ala Ser Thr Trp Gly Ile 
1               5                   10                  15      


Ser Gly Val Ser Ala His Pro Asp Pro Val Phe Ser Ser Ser Glu Gly 
            20                  25                  30          


Ala His Gln Val Leu Arg Val Arg Arg Ala Asn Ser Phe Leu Glu Glu 
        35                  40                  45              


Val Arg Ala Gly Ser Leu Glu Arg Glu Cys Met Glu Glu Ile Cys Asp 
    50                  55                  60                  


Phe Glu Glu Ala Gln Glu Ile Phe Gln Asn Val Glu Asp Thr Leu Ala 
65                  70                  75                  80  


Phe Trp Ile Lys Tyr Phe Asp Gly Asp Gln Cys Ser Thr Pro Pro Leu 
                85                  90                  95      


Asp His Gln Cys Asp Ser Pro Cys Cys Gly His Gly Thr Cys Ile Asp 
            100                 105                 110         


Gly Leu Gly Gly Phe Ser Cys Ser Cys Asp Lys Gly Trp Glu Gly Arg 
        115                 120                 125             


Phe Cys Gln Gln Glu Met Gly Phe Gln Asp Cys Arg Val Lys Asn Gly 
    130                 135                 140                 


Gly Cys Tyr His Tyr Cys Leu Glu Glu Thr Arg Gly Arg Arg Cys Arg 
145                 150                 155                 160 


Cys Ala Pro Gly Tyr Glu Leu Ala Asp Asp His Met His Cys Arg Pro 
                165                 170                 175     


Thr Val Asn Phe Pro Cys Gly Lys Leu Trp Lys Arg Thr Asp Lys Lys 
            180                 185                 190         


Arg Lys Asn Phe Lys Arg Asp Ile Asp Pro Glu Asp Glu Glu Leu Glu 
        195                 200                 205             


Leu Gly Pro Arg Ile Val Asn Gly Thr Leu Thr Lys Gln Gly Asp Ser 
    210                 215                 220                 


Pro Trp Gln Ala Ile Leu Leu Asp Ser Lys Lys Lys Leu Ala Cys Gly 
225                 230                 235                 240 


Gly Val Leu Ile His Thr Ser Trp Val Leu Thr Ala Ala His Cys Leu 
                245                 250                 255     


Glu Ser Ser Lys Lys Leu Thr Val Arg Leu Gly Glu Tyr Asp Leu Arg 
            260                 265                 270         


Arg Arg Asp Pro Trp Glu Leu Asp Leu Asp Ile Lys Glu Val Leu Val 
        275                 280                 285             


His Pro Asn Tyr Thr Arg Ser Asn Ser Asp Asn Asp Ile Ala Leu Leu 
    290                 295                 300                 


Arg Leu Ser Gln Pro Ala Thr Leu Ser Lys Thr Ile Val Pro Ile Cys 
305                 310                 315                 320 


Leu Pro Asn Ser Gly Leu Ala Gln Glu Leu Ser Gln Ala Gly Gln Glu 
                325                 330                 335     


Thr Val Val Thr Gly Trp Gly Tyr Gln Ser Asp Lys Val Lys Asp Gly 
            340                 345                 350         


Arg Arg Asn Arg Thr Phe Ile Leu Thr Phe Ile Arg Ile Pro Leu Ala 
        355                 360                 365             


Ala Arg Asn Asp Cys Met Gln Val Met Asn Asn Val Val Ser Glu Asn 
    370                 375                 380                 


Met Leu Cys Ala Gly Ile Ile Gly Asp Thr Arg Asp Ala Cys Asp Gly 
385                 390                 395                 400 


Asp Ser Gly Gly Pro Met Val Val Phe Phe Arg Gly Thr Trp Phe Leu 
                405                 410                 415     


Val Gly Leu Val Ser Trp Gly Glu Gly Cys Gly His Leu Asn Asn Tyr 
            420                 425                 430         


Gly Val Tyr Thr Lys Val Gly Ser Tyr Leu Lys Trp Ile His Ser Tyr 
        435                 440                 445             


Ile Gly Glu Arg Asp Val Ser Leu Lys Ser Pro Lys Leu 
    450                 455                 460     


<210>  13
<211>  1569
<212>  DNA
<213>  Bos taurus


<220>
<221>  CDS
<222>  (18)..(1460)

<400>  13
tcgagttcca ggctgtc atg gcg gca gga ggg caa cct tgc agt ttc tcc        50
                   Met Ala Ala Gly Gly Gln Pro Cys Ser Phe Ser          
                   1               5                   10               

gcg gcc cac ccc agt ggc tgc agc ttc aga atg tgg cag ctt aca agc       98
Ala Ala His Pro Ser Gly Cys Ser Phe Arg Met Trp Gln Leu Thr Ser         
            15                  20                  25                  

ctc tta ctg ttc gtg acc atc tgg gga att tcc agc aca cca gct cct      146
Leu Leu Leu Phe Val Thr Ile Trp Gly Ile Ser Ser Thr Pro Ala Pro         
        30                  35                  40                      

cct gac tca gtg ttc tcc agc agc cag cgt gcc cac caa gtg ctg cgg      194
Pro Asp Ser Val Phe Ser Ser Ser Gln Arg Ala His Gln Val Leu Arg         
    45                  50                  55                          

atc cgc aaa cgt gcc aac tcc ttc ctg gag gag ctg cgg ccc ggc aac      242
Ile Arg Lys Arg Ala Asn Ser Phe Leu Glu Glu Leu Arg Pro Gly Asn         
60                  65                  70                  75          

gtg gag cgt gag tgc tca gag gag gtc tgt gag ttc gag gaa gct cgg      290
Val Glu Arg Glu Cys Ser Glu Glu Val Cys Glu Phe Glu Glu Ala Arg         
                80                  85                  90              

gag att ttc caa aac acg gaa gac aca atg gcc ttc tgg tcc aag tat      338
Glu Ile Phe Gln Asn Thr Glu Asp Thr Met Ala Phe Trp Ser Lys Tyr         
            95                  100                 105                 

agc gac ggg gac cag tgc gag gac cgg ccc tca ggg agc ccg tgc gac      386
Ser Asp Gly Asp Gln Cys Glu Asp Arg Pro Ser Gly Ser Pro Cys Asp         
        110                 115                 120                     

ctc cca tgc tgt gga cgc ggc aag tgc atc gat ggc ctg ggc ggc ttc      434
Leu Pro Cys Cys Gly Arg Gly Lys Cys Ile Asp Gly Leu Gly Gly Phe         
    125                 130                 135                         

cgc tgc gac tgc gcg gag ggc tgg gag ggc cgc ttc tgc ttg cac gag      482
Arg Cys Asp Cys Ala Glu Gly Trp Glu Gly Arg Phe Cys Leu His Glu         
140                 145                 150                 155         

gtg cgc ttc tcc aac tgc tcg gcg gaa aac ggc ggc tgc gcc cac tac      530
Val Arg Phe Ser Asn Cys Ser Ala Glu Asn Gly Gly Cys Ala His Tyr         
                160                 165                 170             

tgc atg gag gag gag ggc cgg cgc cac tgc agc tgc gcg ccc ggc tac      578
Cys Met Glu Glu Glu Gly Arg Arg His Cys Ser Cys Ala Pro Gly Tyr         
            175                 180                 185                 

cgg ctg gag gac gac cac cag ctc tgc gtg tcc aag gtg acg ttc cct      626
Arg Leu Glu Asp Asp His Gln Leu Cys Val Ser Lys Val Thr Phe Pro         
        190                 195                 200                     

tgt ggg agg cta ggg aag cga atg gag aag aaa cgc aag acc ttg aaa      674
Cys Gly Arg Leu Gly Lys Arg Met Glu Lys Lys Arg Lys Thr Leu Lys         
    205                 210                 215                         

cgt gac aca aac caa gtc gac caa aaa gac cag ttg gat cca cgg att      722
Arg Asp Thr Asn Gln Val Asp Gln Lys Asp Gln Leu Asp Pro Arg Ile         
220                 225                 230                 235         

gtc gat ggg cag gag gct gga tgg gga gag agc ccc tgg cag gca gtg      770
Val Asp Gly Gln Glu Ala Gly Trp Gly Glu Ser Pro Trp Gln Ala Val         
                240                 245                 250             

ctg ctg gac tcc aag aag aag ctg gtc tgt ggg gca gtg cta atc cac      818
Leu Leu Asp Ser Lys Lys Lys Leu Val Cys Gly Ala Val Leu Ile His         
            255                 260                 265                 

gtc tcc tgg gtg ctg acg gtg gcc cac tgc ttg gac agc cgc aag aag      866
Val Ser Trp Val Leu Thr Val Ala His Cys Leu Asp Ser Arg Lys Lys         
        270                 275                 280                     

ctc atc gtc agg ctc ggg gag tat gac atg cgg cgc tgg gag agc tgg      914
Leu Ile Val Arg Leu Gly Glu Tyr Asp Met Arg Arg Trp Glu Ser Trp         
    285                 290                 295                         

gag gtg gac ctg gac atc aag gag gtc atc atc cac cct aac tat acc      962
Glu Val Asp Leu Asp Ile Lys Glu Val Ile Ile His Pro Asn Tyr Thr         
300                 305                 310                 315         

aag agc acc agt gac aac gac atc gcc ctg ctc cgc ctg gcc aag cct     1010
Lys Ser Thr Ser Asp Asn Asp Ile Ala Leu Leu Arg Leu Ala Lys Pro         
                320                 325                 330             

gcc act ctt tcg cag acc att gtg ccc atc tgt ctc ccg gat agt ggc     1058
Ala Thr Leu Ser Gln Thr Ile Val Pro Ile Cys Leu Pro Asp Ser Gly         
            335                 340                 345                 

ctc tct gag cgc aag ctc acc cag gtc ggc cag gag act gtg gtg aca     1106
Leu Ser Glu Arg Lys Leu Thr Gln Val Gly Gln Glu Thr Val Val Thr         
        350                 355                 360                     

ggc tgg ggc tac cgt gac gag acc aag aga aac cgc acc ttc gtc ctc     1154
Gly Trp Gly Tyr Arg Asp Glu Thr Lys Arg Asn Arg Thr Phe Val Leu         
    365                 370                 375                         

agc ttc atc aag gtc cct gtg gtc ccg tac aat gca tgt gtc cat gcc     1202
Ser Phe Ile Lys Val Pro Val Val Pro Tyr Asn Ala Cys Val His Ala         
380                 385                 390                 395         

atg gaa aac aag atc tct gag aac atg ctg tgc gct ggt atc ctc ggg     1250
Met Glu Asn Lys Ile Ser Glu Asn Met Leu Cys Ala Gly Ile Leu Gly         
                400                 405                 410             

gac ccg agg gat gcc tgt gag ggc gac agt ggg ggg cct atg gtc acc     1298
Asp Pro Arg Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Met Val Thr         
            415                 420                 425                 

ttc ttc cgt ggc acc tgg ttc ctg gtg ggc ctg gtg agc tgg ggc gag     1346
Phe Phe Arg Gly Thr Trp Phe Leu Val Gly Leu Val Ser Trp Gly Glu         
        430                 435                 440                     

ggc tgt ggg cgc ctc tac aac tac ggc gtt tac acc aaa gtc agc cgt     1394
Gly Cys Gly Arg Leu Tyr Asn Tyr Gly Val Tyr Thr Lys Val Ser Arg         
    445                 450                 455                         

tac ctt gac tgg atc tac ggc cac atc aaa gct cag gag gcc cct ctt     1442
Tyr Leu Asp Trp Ile Tyr Gly His Ile Lys Ala Gln Glu Ala Pro Leu         
460                 465                 470                 475         

gag agc cag gtg cct tag catcccccgt cacttgtgtc tgggccccag            1490
Glu Ser Gln Val Pro                                                     
                480                                                     

aggacaccct tggatagggg ctggattgtt gaatggcaag atggtggaca ttaaaaaagg   1550

gcttgctgca agcacacca                                                1569


<210>  14
<211>  480
<212>  PRT
<213>  Bos taurus

<400>  14

Met Ala Ala Gly Gly Gln Pro Cys Ser Phe Ser Ala Ala His Pro Ser 
1               5                   10                  15      


Gly Cys Ser Phe Arg Met Trp Gln Leu Thr Ser Leu Leu Leu Phe Val 
            20                  25                  30          


Thr Ile Trp Gly Ile Ser Ser Thr Pro Ala Pro Pro Asp Ser Val Phe 
        35                  40                  45              


Ser Ser Ser Gln Arg Ala His Gln Val Leu Arg Ile Arg Lys Arg Ala 
    50                  55                  60                  


Asn Ser Phe Leu Glu Glu Leu Arg Pro Gly Asn Val Glu Arg Glu Cys 
65                  70                  75                  80  


Ser Glu Glu Val Cys Glu Phe Glu Glu Ala Arg Glu Ile Phe Gln Asn 
                85                  90                  95      


Thr Glu Asp Thr Met Ala Phe Trp Ser Lys Tyr Ser Asp Gly Asp Gln 
            100                 105                 110         


Cys Glu Asp Arg Pro Ser Gly Ser Pro Cys Asp Leu Pro Cys Cys Gly 
        115                 120                 125             


Arg Gly Lys Cys Ile Asp Gly Leu Gly Gly Phe Arg Cys Asp Cys Ala 
    130                 135                 140                 


Glu Gly Trp Glu Gly Arg Phe Cys Leu His Glu Val Arg Phe Ser Asn 
145                 150                 155                 160 


Cys Ser Ala Glu Asn Gly Gly Cys Ala His Tyr Cys Met Glu Glu Glu 
                165                 170                 175     


Gly Arg Arg His Cys Ser Cys Ala Pro Gly Tyr Arg Leu Glu Asp Asp 
            180                 185                 190         


His Gln Leu Cys Val Ser Lys Val Thr Phe Pro Cys Gly Arg Leu Gly 
        195                 200                 205             


Lys Arg Met Glu Lys Lys Arg Lys Thr Leu Lys Arg Asp Thr Asn Gln 
    210                 215                 220                 


Val Asp Gln Lys Asp Gln Leu Asp Pro Arg Ile Val Asp Gly Gln Glu 
225                 230                 235                 240 


Ala Gly Trp Gly Glu Ser Pro Trp Gln Ala Val Leu Leu Asp Ser Lys 
                245                 250                 255     


Lys Lys Leu Val Cys Gly Ala Val Leu Ile His Val Ser Trp Val Leu 
            260                 265                 270         


Thr Val Ala His Cys Leu Asp Ser Arg Lys Lys Leu Ile Val Arg Leu 
        275                 280                 285             


Gly Glu Tyr Asp Met Arg Arg Trp Glu Ser Trp Glu Val Asp Leu Asp 
    290                 295                 300                 


Ile Lys Glu Val Ile Ile His Pro Asn Tyr Thr Lys Ser Thr Ser Asp 
305                 310                 315                 320 


Asn Asp Ile Ala Leu Leu Arg Leu Ala Lys Pro Ala Thr Leu Ser Gln 
                325                 330                 335     


Thr Ile Val Pro Ile Cys Leu Pro Asp Ser Gly Leu Ser Glu Arg Lys 
            340                 345                 350         


Leu Thr Gln Val Gly Gln Glu Thr Val Val Thr Gly Trp Gly Tyr Arg 
        355                 360                 365             


Asp Glu Thr Lys Arg Asn Arg Thr Phe Val Leu Ser Phe Ile Lys Val 
    370                 375                 380                 


Pro Val Val Pro Tyr Asn Ala Cys Val His Ala Met Glu Asn Lys Ile 
385                 390                 395                 400 


Ser Glu Asn Met Leu Cys Ala Gly Ile Leu Gly Asp Pro Arg Asp Ala 
                405                 410                 415     


Cys Glu Gly Asp Ser Gly Gly Pro Met Val Thr Phe Phe Arg Gly Thr 
            420                 425                 430         


Trp Phe Leu Val Gly Leu Val Ser Trp Gly Glu Gly Cys Gly Arg Leu 
        435                 440                 445             


Tyr Asn Tyr Gly Val Tyr Thr Lys Val Ser Arg Tyr Leu Asp Trp Ile 
    450                 455                 460                 


Tyr Gly His Ile Lys Ala Gln Glu Ala Pro Leu Glu Ser Gln Val Pro 
465                 470                 475                 480 


<210>  15
<211>  1514
<212>  DNA
<213>  Sus scrofa


<220>
<221>  CDS
<222>  (22)..(1401)

<400>  15
cgttgctgtc gcaactccag a atg tgg caa ctt gca agc ctc tta ctg ctc       51
                        Met Trp Gln Leu Ala Ser Leu Leu Leu Leu         
                        1               5                   10          

ctg atc atc tgg gca gtt tcc agc aca cca gtt cct cct gac tca gtg       99
Leu Ile Ile Trp Ala Val Ser Ser Thr Pro Val Pro Pro Asp Ser Val         
                15                  20                  25              

ttc tcc agc agc cag cgg gcc cac cag atg ctg cgc agc aaa cgc gcc      147
Phe Ser Ser Ser Gln Arg Ala His Gln Met Leu Arg Ser Lys Arg Ala         
            30                  35                  40                  

aac tcc ttc ctg gag gag ctg cgg ccc agc agc ctg gag cgt gag tgc      195
Asn Ser Phe Leu Glu Glu Leu Arg Pro Ser Ser Leu Glu Arg Glu Cys         
        45                  50                  55                      

aag gag gag acc tgt gat ttc gag gag gct cgg gag att ttc caa aac      243
Lys Glu Glu Thr Cys Asp Phe Glu Glu Ala Arg Glu Ile Phe Gln Asn         
    60                  65                  70                          

acg gaa aac aca atg gcc ttc tgg tcc aag tac cat gac ggg gac cag      291
Thr Glu Asn Thr Met Ala Phe Trp Ser Lys Tyr His Asp Gly Asp Gln         
75                  80                  85                  90          

tgc gcg gtc tcg ccc cct gag cac ctg tgc gac agc ccg tgc tgc ggg      339
Cys Ala Val Ser Pro Pro Glu His Leu Cys Asp Ser Pro Cys Cys Gly         
                95                  100                 105             

cgt ggc acc tgt atc gac ggc ctg ggc ggc ttc cgc tgc gac tgc gct      387
Arg Gly Thr Cys Ile Asp Gly Leu Gly Gly Phe Arg Cys Asp Cys Ala         
            110                 115                 120                 

cag ggc tgg gag ggc cgc ttc tgc ctg cac gag gtg cgc ttc tcc aac      435
Gln Gly Trp Glu Gly Arg Phe Cys Leu His Glu Val Arg Phe Ser Asn         
        125                 130                 135                     

tgc tcg acg gaa aac ggt ggc tgt gcg cac tac tgc ctg gag gag gag      483
Cys Ser Thr Glu Asn Gly Gly Cys Ala His Tyr Cys Leu Glu Glu Glu         
    140                 145                 150                         

ggc ggg cgc cgc tgc gct tgc gcg cca ggc tac cgg ctg ggg gac gac      531
Gly Gly Arg Arg Cys Ala Cys Ala Pro Gly Tyr Arg Leu Gly Asp Asp         
155                 160                 165                 170         

cac ctg cag tgc gag cca aag gtg agg tcc cct tgc ggg agg cta ggg      579
His Leu Gln Cys Glu Pro Lys Val Arg Ser Pro Cys Gly Arg Leu Gly         
                175                 180                 185             

aat cgc atg gag aag aaa cgc aag aac ttg aag cgt gat aca gac caa      627
Asn Arg Met Glu Lys Lys Arg Lys Asn Leu Lys Arg Asp Thr Asp Gln         
            190                 195                 200                 

gtt gac aaa aaa gaa gac caa ata gat ccg agg ctc gtc aat ggg aag      675
Val Asp Lys Lys Glu Asp Gln Ile Asp Pro Arg Leu Val Asn Gly Lys         
        205                 210                 215                     

cag tcc cca tgg gga gag agc ccc tgg cag gtg atc ctg ctg gac tca      723
Gln Ser Pro Trp Gly Glu Ser Pro Trp Gln Val Ile Leu Leu Asp Ser         
    220                 225                 230                         

aag aag aag ctg gcc tgt ggg gca gtg ctc atc cat gtc tcc tgg gtg      771
Lys Lys Lys Leu Ala Cys Gly Ala Val Leu Ile His Val Ser Trp Val         
235                 240                 245                 250         

ctg aca gcg gcc cac tgc ttg gac gac tac aag aag ctc act gtc agg      819
Leu Thr Ala Ala His Cys Leu Asp Asp Tyr Lys Lys Leu Thr Val Arg         
                255                 260                 265             

ctc ggc gaa tat gat ctg agg cgt cgg gaa aaa tgg gag gta gac ctg      867
Leu Gly Glu Tyr Asp Leu Arg Arg Arg Glu Lys Trp Glu Val Asp Leu         
            270                 275                 280                 

gac atc aag gag ttc ctc gtc cac cct aac tac acc agg agc acc agt      915
Asp Ile Lys Glu Phe Leu Val His Pro Asn Tyr Thr Arg Ser Thr Ser         
        285                 290                 295                     

gac aat gac atc gcc ctg ctc cgc ctg gcc gaa ccg gcc act ttc tcg      963
Asp Asn Asp Ile Ala Leu Leu Arg Leu Ala Glu Pro Ala Thr Phe Ser         
    300                 305                 310                         

cag acc atc gtg ccc atc tgc ctc cca gac agt ggc ctc tct gag cgt     1011
Gln Thr Ile Val Pro Ile Cys Leu Pro Asp Ser Gly Leu Ser Glu Arg         
315                 320                 325                 330         

gag ctc acc cgg gtt ggc caa gag acg gtg gtg acc ggc tgg ggc tac     1059
Glu Leu Thr Arg Val Gly Gln Glu Thr Val Val Thr Gly Trp Gly Tyr         
                335                 340                 345             

cgc agc gag gcc aag aca aac cgc agc ttc atc ctc aac ttc atc aag     1107
Arg Ser Glu Ala Lys Thr Asn Arg Ser Phe Ile Leu Asn Phe Ile Lys         
            350                 355                 360                 

gtc cct gtg gcc ccg cac aat gag tgc gtc cag gcc atg cac aac aag     1155
Val Pro Val Ala Pro His Asn Glu Cys Val Gln Ala Met His Asn Lys         
        365                 370                 375                     

atc tct gag aac atg ctg tgt gca ggc atc ctg ggg gac tct cgt gat     1203
Ile Ser Glu Asn Met Leu Cys Ala Gly Ile Leu Gly Asp Ser Arg Asp         
    380                 385                 390                         

gcc tgc gag ggc gac agc ggg ggg cct atg gtg gcc tcc ttc cgc ggc     1251
Ala Cys Glu Gly Asp Ser Gly Gly Pro Met Val Ala Ser Phe Arg Gly         
395                 400                 405                 410         

acc tgg ttc ctg gtg ggc ctg gtg agc tgg ggt gag ggc tgt ggg cgc     1299
Thr Trp Phe Leu Val Gly Leu Val Ser Trp Gly Glu Gly Cys Gly Arg         
                415                 420                 425             

ctc cac aac tat ggc gtt tac acc aaa gtc agc cgt tac ctc gac tgg     1347
Leu His Asn Tyr Gly Val Tyr Thr Lys Val Ser Arg Tyr Leu Asp Trp         
            430                 435                 440                 

atc cat ggc cac atc aga atg gag gag gcc ttc cac aag aac cag gtg     1395
Ile His Gly His Ile Arg Met Glu Glu Ala Phe His Lys Asn Gln Val         
        445                 450                 455                     

cct tag tgtctcccta ccccactgct tgggccccag gggccatcct cgggtggggg      1451
Pro                                                                     
                                                                        

ctggtttgtt gaatggcaac agtaggacaa taaaggggca tgcagtaagc aaaaaaaaaa   1511

aaa                                                                 1514


<210>  16
<211>  459
<212>  PRT
<213>  Sus scrofa

<400>  16

Met Trp Gln Leu Ala Ser Leu Leu Leu Leu Leu Ile Ile Trp Ala Val 
1               5                   10                  15      


Ser Ser Thr Pro Val Pro Pro Asp Ser Val Phe Ser Ser Ser Gln Arg 
            20                  25                  30          


Ala His Gln Met Leu Arg Ser Lys Arg Ala Asn Ser Phe Leu Glu Glu 
        35                  40                  45              


Leu Arg Pro Ser Ser Leu Glu Arg Glu Cys Lys Glu Glu Thr Cys Asp 
    50                  55                  60                  


Phe Glu Glu Ala Arg Glu Ile Phe Gln Asn Thr Glu Asn Thr Met Ala 
65                  70                  75                  80  


Phe Trp Ser Lys Tyr His Asp Gly Asp Gln Cys Ala Val Ser Pro Pro 
                85                  90                  95      


Glu His Leu Cys Asp Ser Pro Cys Cys Gly Arg Gly Thr Cys Ile Asp 
            100                 105                 110         


Gly Leu Gly Gly Phe Arg Cys Asp Cys Ala Gln Gly Trp Glu Gly Arg 
        115                 120                 125             


Phe Cys Leu His Glu Val Arg Phe Ser Asn Cys Ser Thr Glu Asn Gly 
    130                 135                 140                 


Gly Cys Ala His Tyr Cys Leu Glu Glu Glu Gly Gly Arg Arg Cys Ala 
145                 150                 155                 160 


Cys Ala Pro Gly Tyr Arg Leu Gly Asp Asp His Leu Gln Cys Glu Pro 
                165                 170                 175     


Lys Val Arg Ser Pro Cys Gly Arg Leu Gly Asn Arg Met Glu Lys Lys 
            180                 185                 190         


Arg Lys Asn Leu Lys Arg Asp Thr Asp Gln Val Asp Lys Lys Glu Asp 
        195                 200                 205             


Gln Ile Asp Pro Arg Leu Val Asn Gly Lys Gln Ser Pro Trp Gly Glu 
    210                 215                 220                 


Ser Pro Trp Gln Val Ile Leu Leu Asp Ser Lys Lys Lys Leu Ala Cys 
225                 230                 235                 240 


Gly Ala Val Leu Ile His Val Ser Trp Val Leu Thr Ala Ala His Cys 
                245                 250                 255     


Leu Asp Asp Tyr Lys Lys Leu Thr Val Arg Leu Gly Glu Tyr Asp Leu 
            260                 265                 270         


Arg Arg Arg Glu Lys Trp Glu Val Asp Leu Asp Ile Lys Glu Phe Leu 
        275                 280                 285             


Val His Pro Asn Tyr Thr Arg Ser Thr Ser Asp Asn Asp Ile Ala Leu 
    290                 295                 300                 


Leu Arg Leu Ala Glu Pro Ala Thr Phe Ser Gln Thr Ile Val Pro Ile 
305                 310                 315                 320 


Cys Leu Pro Asp Ser Gly Leu Ser Glu Arg Glu Leu Thr Arg Val Gly 
                325                 330                 335     


Gln Glu Thr Val Val Thr Gly Trp Gly Tyr Arg Ser Glu Ala Lys Thr 
            340                 345                 350         


Asn Arg Ser Phe Ile Leu Asn Phe Ile Lys Val Pro Val Ala Pro His 
        355                 360                 365             


Asn Glu Cys Val Gln Ala Met His Asn Lys Ile Ser Glu Asn Met Leu 
    370                 375                 380                 


Cys Ala Gly Ile Leu Gly Asp Ser Arg Asp Ala Cys Glu Gly Asp Ser 
385                 390                 395                 400 


Gly Gly Pro Met Val Ala Ser Phe Arg Gly Thr Trp Phe Leu Val Gly 
                405                 410                 415     


Leu Val Ser Trp Gly Glu Gly Cys Gly Arg Leu His Asn Tyr Gly Val 
            420                 425                 430         


Tyr Thr Lys Val Ser Arg Tyr Leu Asp Trp Ile His Gly His Ile Arg 
        435                 440                 445             


Met Glu Glu Ala Phe His Lys Asn Gln Val Pro 
    450                 455                 


<210>  17
<211>  1776
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (74)..(1459)

<400>  17
gctgtcatgg cggcaggacg gcgaacttgc agtatctcca cgacccgccc ctacaggtgc     60

cagtgcctcc aga atg tgg cag ctc aca agc ctc ctg ctg ttc gtg gcc       109
               Met Trp Gln Leu Thr Ser Leu Leu Leu Phe Val Ala          
               1               5                   10                   

acc tgg gga att tcc ggc aca cca gct cct ctt gac tca gtg ttc tcc      157
Thr Trp Gly Ile Ser Gly Thr Pro Ala Pro Leu Asp Ser Val Phe Ser         
        15                  20                  25                      

agc agc gag cgt gcc cac cag gtg ctg cgg atc cgc aaa cgt gcc aac      205
Ser Ser Glu Arg Ala His Gln Val Leu Arg Ile Arg Lys Arg Ala Asn         
    30                  35                  40                          

tcc ttc ctg gag gag ctc cgt cac agc agc ctg gag cgg gag tgc ata      253
Ser Phe Leu Glu Glu Leu Arg His Ser Ser Leu Glu Arg Glu Cys Ile         
45                  50                  55                  60          

gag gag atc tgt gac ttc gag gag gcc aag gaa att ttc caa aat gtg      301
Glu Glu Ile Cys Asp Phe Glu Glu Ala Lys Glu Ile Phe Gln Asn Val         
                65                  70                  75              

gat gac aca ctg gcc ttc tgg tcc aag cac gtc gac ggt gac cag tgc      349
Asp Asp Thr Leu Ala Phe Trp Ser Lys His Val Asp Gly Asp Gln Cys         
            80                  85                  90                  

ttg gtc ttg ccc ttg gag cac ccg tgc gcc agc ctg tgc tgc ggg cac      397
Leu Val Leu Pro Leu Glu His Pro Cys Ala Ser Leu Cys Cys Gly His         
        95                  100                 105                     

ggc acg tgc atc gac ggc atc ggc agc ttc agc tgc gac tgc cgc agc      445
Gly Thr Cys Ile Asp Gly Ile Gly Ser Phe Ser Cys Asp Cys Arg Ser         
    110                 115                 120                         

ggc tgg gag ggc cgc ttc tgc cag cgc gag gtg agc ttc ctc aat tgc      493
Gly Trp Glu Gly Arg Phe Cys Gln Arg Glu Val Ser Phe Leu Asn Cys         
125                 130                 135                 140         

tcg ctg gac aac ggc ggc tgc acg cat tac tgc cta gag gag gtg ggc      541
Ser Leu Asp Asn Gly Gly Cys Thr His Tyr Cys Leu Glu Glu Val Gly         
                145                 150                 155             

tgg cgg cgc tgt agc tgt gcg cct ggc tac aag ctg ggg gac gac ctc      589
Trp Arg Arg Cys Ser Cys Ala Pro Gly Tyr Lys Leu Gly Asp Asp Leu         
            160                 165                 170                 

ctg cag tgt cac ccc gca gtg aag ttc cct tgt ggg agg ccc tgg aag      637
Leu Gln Cys His Pro Ala Val Lys Phe Pro Cys Gly Arg Pro Trp Lys         
        175                 180                 185                     

cgg atg gag aag aag cgc agt cac ctg aaa cga gac aca gaa gac caa      685
Arg Met Glu Lys Lys Arg Ser His Leu Lys Arg Asp Thr Glu Asp Gln         
    190                 195                 200                         

gaa gac caa gta gat ccg cgg ctc att gat ggg aag atg acc agg cgg      733
Glu Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys Met Thr Arg Arg         
205                 210                 215                 220         

gga gac agc ccc tgg cag gtg gtc ctg ctg gac tca aag aag aag ctg      781
Gly Asp Ser Pro Trp Gln Val Val Leu Leu Asp Ser Lys Lys Lys Leu         
                225                 230                 235             

gcc tgc ggg gca gtg ctc atc cac ccc tcc tgg gtg ctg aca gcg gcc      829
Ala Cys Gly Ala Val Leu Ile His Pro Ser Trp Val Leu Thr Ala Ala         
            240                 245                 250                 

cac tgc atg gat gag tcc aag aag ctc ctt gtc tgc ctt gga gag tat      877
His Cys Met Asp Glu Ser Lys Lys Leu Leu Val Cys Leu Gly Glu Tyr         
        255                 260                 265                     

gac ctg cgg cgc tgg gag aag tgg gag ctg tgc ctg gac atc aag gag      925
Asp Leu Arg Arg Trp Glu Lys Trp Glu Leu Cys Leu Asp Ile Lys Glu         
    270                 275                 280                         

gtc ttc gtc cac ccc aac tac agc aag agc acc acc gac aat gac atc      973
Val Phe Val His Pro Asn Tyr Ser Lys Ser Thr Thr Asp Asn Asp Ile         
285                 290                 295                 300         

gca ctg ctg cac ctg gcc cag ccc gcc acc ctc tcg cag acc ata gtg     1021
Ala Leu Leu His Leu Ala Gln Pro Ala Thr Leu Ser Gln Thr Ile Val         
                305                 310                 315             

ccc atc tgc ctc ccg gac agc ggc ctt gca gag cgc gag ctc aat cag     1069
Pro Ile Cys Leu Pro Asp Ser Gly Leu Ala Glu Arg Glu Leu Asn Gln         
            320                 325                 330                 

gcc ggc cag gag acc ctc gtg acg ggc tgg ggc tac cac agc agc cga     1117
Ala Gly Gln Glu Thr Leu Val Thr Gly Trp Gly Tyr His Ser Ser Arg         
        335                 340                 345                     

gag aag gag gcc aag aga aac cgc acc ttc gtc ctc aac ttc atc aag     1165
Glu Lys Glu Ala Lys Arg Asn Arg Thr Phe Val Leu Asn Phe Ile Lys         
    350                 355                 360                         

att ccc gtg gtc ccg cac aat gag tgc agc gag gtc atg agc aac atg     1213
Ile Pro Val Val Pro His Asn Glu Cys Ser Glu Val Met Ser Asn Met         
365                 370                 375                 380         

gtg tct gag aac atg ctg tgt gcg ggc atc ctc ggg gac cgg cag gat     1261
Val Ser Glu Asn Met Leu Cys Ala Gly Ile Leu Gly Asp Arg Gln Asp         
                385                 390                 395             

gcc tgc gag ggc gac agt ggg ggg ccc atg gtc gcc tcc ttc cac ggc     1309
Ala Cys Glu Gly Asp Ser Gly Gly Pro Met Val Ala Ser Phe His Gly         
            400                 405                 410                 

acc tgg ttc ctg gtg ggc ctg gtg agc tgg ggt gag ggc tgt ggg ctc     1357
Thr Trp Phe Leu Val Gly Leu Val Ser Trp Gly Glu Gly Cys Gly Leu         
        415                 420                 425                     

ctt cac aac tac ggc gtt tac acc aaa gtc agc cgc tac ctc gac tgg     1405
Leu His Asn Tyr Gly Val Tyr Thr Lys Val Ser Arg Tyr Leu Asp Trp         
    430                 435                 440                         

atc cat ggg cac atc aga gac aag gaa gcc ccc cag aag agc tgg gca     1453
Ile His Gly His Ile Arg Asp Lys Glu Ala Pro Gln Lys Ser Trp Ala         
445                 450                 455                 460         

cct tag cgaccctccc tgcagggctg ggcttttgca tggcaatgga tgggacatta      1509
Pro                                                                     
                                                                        

aagggacatg taacaagcac accggcctgc tgttctgtcc ttccatccct cttttgggct   1569

cttctggagg gaagtaacat ttactgagca cctgttgtat gtcacatgcc ttatgaatag   1629

aatcttaact cctagagcaa ctctgtgggg tggggaggag cagatccaag ttttgcgggg   1689

tctaaagctg tgtgtgttga gggggatact ctgtttatga aaaagaataa aaaacacaac   1749

cacgaaaaaa aaaaaaaaaa aaaaaaa                                       1776


<210>  18
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Trp Gln Leu Thr Ser Leu Leu Leu Phe Val Ala Thr Trp Gly Ile 
1               5                   10                  15      


Ser Gly Thr Pro Ala Pro Leu Asp Ser Val Phe Ser Ser Ser Glu Arg 
            20                  25                  30          


Ala His Gln Val Leu Arg Ile Arg Lys Arg Ala Asn Ser Phe Leu Glu 
        35                  40                  45              


Glu Leu Arg His Ser Ser Leu Glu Arg Glu Cys Ile Glu Glu Ile Cys 
    50                  55                  60                  


Asp Phe Glu Glu Ala Lys Glu Ile Phe Gln Asn Val Asp Asp Thr Leu 
65                  70                  75                  80  


Ala Phe Trp Ser Lys His Val Asp Gly Asp Gln Cys Leu Val Leu Pro 
                85                  90                  95      


Leu Glu His Pro Cys Ala Ser Leu Cys Cys Gly His Gly Thr Cys Ile 
            100                 105                 110         


Asp Gly Ile Gly Ser Phe Ser Cys Asp Cys Arg Ser Gly Trp Glu Gly 
        115                 120                 125             


Arg Phe Cys Gln Arg Glu Val Ser Phe Leu Asn Cys Ser Leu Asp Asn 
    130                 135                 140                 


Gly Gly Cys Thr His Tyr Cys Leu Glu Glu Val Gly Trp Arg Arg Cys 
145                 150                 155                 160 


Ser Cys Ala Pro Gly Tyr Lys Leu Gly Asp Asp Leu Leu Gln Cys His 
                165                 170                 175     


Pro Ala Val Lys Phe Pro Cys Gly Arg Pro Trp Lys Arg Met Glu Lys 
            180                 185                 190         


Lys Arg Ser His Leu Lys Arg Asp Thr Glu Asp Gln Glu Asp Gln Val 
        195                 200                 205             


Asp Pro Arg Leu Ile Asp Gly Lys Met Thr Arg Arg Gly Asp Ser Pro 
    210                 215                 220                 


Trp Gln Val Val Leu Leu Asp Ser Lys Lys Lys Leu Ala Cys Gly Ala 
225                 230                 235                 240 


Val Leu Ile His Pro Ser Trp Val Leu Thr Ala Ala His Cys Met Asp 
                245                 250                 255     


Glu Ser Lys Lys Leu Leu Val Cys Leu Gly Glu Tyr Asp Leu Arg Arg 
            260                 265                 270         


Trp Glu Lys Trp Glu Leu Cys Leu Asp Ile Lys Glu Val Phe Val His 
        275                 280                 285             


Pro Asn Tyr Ser Lys Ser Thr Thr Asp Asn Asp Ile Ala Leu Leu His 
    290                 295                 300                 


Leu Ala Gln Pro Ala Thr Leu Ser Gln Thr Ile Val Pro Ile Cys Leu 
305                 310                 315                 320 


Pro Asp Ser Gly Leu Ala Glu Arg Glu Leu Asn Gln Ala Gly Gln Glu 
                325                 330                 335     


Thr Leu Val Thr Gly Trp Gly Tyr His Ser Ser Arg Glu Lys Glu Ala 
            340                 345                 350         


Lys Arg Asn Arg Thr Phe Val Leu Asn Phe Ile Lys Ile Pro Val Val 
        355                 360                 365             


Pro His Asn Glu Cys Ser Glu Val Met Ser Asn Met Val Ser Glu Asn 
    370                 375                 380                 


Met Leu Cys Ala Gly Ile Leu Gly Asp Arg Gln Asp Ala Cys Glu Gly 
385                 390                 395                 400 


Asp Ser Gly Gly Pro Met Val Ala Ser Phe His Gly Thr Trp Phe Leu 
                405                 410                 415     


Val Gly Leu Val Ser Trp Gly Glu Gly Cys Gly Leu Leu His Asn Tyr 
            420                 425                 430         


Gly Val Tyr Thr Lys Val Ser Arg Tyr Leu Asp Trp Ile His Gly His 
        435                 440                 445             


Ile Arg Asp Lys Glu Ala Pro Gln Lys Ser Trp Ala Pro 
    450                 455                 460     


