                               SEQUENCE LISTING                               

<110> THE JACKSON LABORATORY

<120> METHODS FOR THERAPEUTIC AND DIAGNOSTIC OF
      NEURODEGENERATIVE DISEASES AND MITOCHONDRIAL DISORDERS

<130> 060636-059881-PCT

<140>
<141>

<150> 60/936,624
<151> 2007-06-21

<160> 6                             

<170> PatentIn Ver. 3.3

<210> 1
<211> 3139
<212> DNA
<213> Homo sapiens

<400> 1
ccgtgttctg cgttgccggc cgtgggtgct ctggccacag tgagttaggg gcgtcggagc 60    
gggtttctcc aaccgcaatc ggctccgctc aaggggagga ggagagtccc ttctcggaag 120   
gcctaaggaa acgtgtcgtc tggaatgggc ttgggggcca cgcctgcaca tctccgcgag 180   
acagagggat aaagtgaaga tggtgctgtt attgttacct cgagtgccac atgcgacctc 240   
tgagatatgt acacagtcat tcttactatc gcactcagcc attcttacta cgctaaagaa 300   
gaaataatta ttcgaggata tttgcctggc ccagaagaaa cttatgtaaa tttcatgaac 360   
tattatatcc gttttcctcg gagtgagaga aaactctttt tagatatcat ctgagaggta 420   
gttaatttgg caccatgggg atacagggat tgctacaatt tatcaaagaa gcttcagaac 480   
ccatccatgt gaggaagtat aaagggcagg tagtagctgt ggatacatat tgctggcttc 540   
acaaaggagc tattgcttgt gctgaaaaac tagccaaagg tgaacctact gataggtatg 600   
taggattttg tatgaaattt gtaaatatgt tactatctca tgggatcaag cctattctcg 660   
tatttgatgg atgtacttta ccttctaaaa aggaagtaga gagatctaga agagaaagac 720   
gacaagccaa tcttcttaag ggaaagcaac ttcttcgtga ggggaaagtc tcggaagctc 780   
gagagtgttt cacccggtct atcaatatca cacatgccat ggcccacaaa gtaattaaag 840   
ctgcccggtc tcagggggta gattgcctcg tggctcccta tgaagctgat gcgcagttgg 900   
cctatcttaa caaagcggga attgtgcaag ccataattac agaggactcg gatctcctag 960   
cttttggctg taaaaaggta attttaaaga tggaccagtt tggaaatgga cttgaaattg 1020  
atcaagctcg gctaggaatg tgcagacagc ttggggatgt attcacggaa gagaagtttc 1080  
gttacatgtg tattctttca ggttgtgact acctgtcatc actgcgtggg attggattag 1140  
caaaggcatg caaagtccta agactagcca ataatccaga tatagtaaag gttatcaaga 1200  
aaattggaca ttatctcaag atgaatatca cggtaccaga ggattacatc aacgggttta 1260  
ttcgggccaa caataccttc ctctatcagc tagtttttga tcccatcaaa aggaaactta 1320  
ttcctctgaa cgcctatgaa gatgatgttg atcctgaaac actaagctac gctgggcaat 1380  
atgttgatga ttccatagct cttcaaatag cacttggaaa taaagatata aatacttttg 1440  
aacagatcga tgactacaat ccagacactg ctatgcctgc ccattcaaga agtcatagtt 1500  
gggatgacaa aacatgtcaa aagtcagcta atgttagcag catttggcat aggaattact 1560  
ctcccagacc agagtcgggt actgtttcag atgccccaca attgaaggaa aatccaagta 1620  
ctgtgggagt ggaacgagtg attagtacta aagggttaaa tctcccaagg aaatcatcca 1680  
ttgtgaaaag accaagaagt gcagagctgt cagaagatga cctgttgagt cagtattctc 1740  
tttcatttac gaagaagacc aagaaaaata gctctgaagg caataaatca ttgagctttt 1800  
ctgaagtgtt tgtgcctgac ctggtaaatg gacctactaa caaaaagagt gtaagcactc 1860  
cacctaggac gagaaataaa tttgcaacat ttttacaaag gaaaaatgaa gaaagtggtg 1920  
cagttgtggt tccagggacc agaagcaggt ttttttgcag ttcagattct actgactgtg 1980  
tatcaaacaa agtgagcatc cagcctctgg atgaaactgc tgtcacagat aaagagaaca 2040  
atctgcatga atcagagtat ggagaccaag aaggcaagag actggttgac acagatgtag 2100  
cacgtaattc aagtgatgac attccgaata atcatattcc aggtgatcat attccagaca 2160  
aggcaacagt gtttacagat gaagagtcct actcttttga gagcagcaaa tttacaagga 2220  
ccatttcacc acccactttg ggaacactaa gaagttgttt tagttggtct ggaggtcttg 2280  
gagatttttc aagaacgccg agcccctctc caagcacagc attgcagcag ttccgaagaa 2340  
agagcgattc ccccacctct ttgcctgaga ataatatgtc tgatgtgtcg cagttaaaga 2400  
gcgaggagtc cagtgacgat gagtctcatc ccttacgaga aggggcatgt tcttcacagt 2460  
cccaggaaag tggagaattc tcactgcaga gttcaaatgc atcaaagctt tctcagtgct 2520  
ctagtaagga ctctgattca gaggaatctg attgcaatat taagttactt gacagtcaaa 2580  
gtgaccagac ctccaagcta tgtttatctc atttctcaaa aaaagacaca cctctaagga 2640  
acaaggttcc tgggctatat aagtccagtt ctgcagactc tctttctaca accaagatca 2700  
aacctctagg acctgccaga gccagtgggc tgagcaagaa gccggcaagc atccagaaga 2760  
gaaagcatca taatgccgag aacaagccgg ggttacagat caaactcaat gagctctgga 2820  
aaaactttgg atttaaaaaa gattctgaaa agcttcctcc ttgtaagaaa cccctgtccc 2880  
cagtcagaga taacatccaa ctaactccag aagcggaaga ggatatattt aacaaacctg 2940  
aatgtggccg tgttcaaaga gcaatattcc agtaaatgca gactgctgca aagcttttgc 3000  
ctgcaagaga atctgatcaa tttgaagtcc ctgtttggga atgaggcact tatcagcatg 3060  
aagaattttt tctcattctg tgccatttta aaaatagaat acattttgta tattaacttt 3120  
aaaaaaaaaa aaaaaaaaa                                              3139  


<210> 2
<211> 3245
<212> DNA
<213> Homo sapiens

<400> 2
cccgtgttct gcgttgccgg ccgtgggtgc tctggccaca gtgagttagg ggcgtcggag 60    
cgggtttctc caaccgcaat cggctccgct caaggggagg aggagagtcc cttctcggaa 120   
ggcctaagga aacgtgtcgt ctggaatggg cttgggggcc acgcctgcac atctccgcga 180   
gacagaggga taaagtgaag atggtgctgt tattgttacc tcgagtgcca catgcgacct 240   
ctgagatatg tacacagtca ttcttactat cgcactcagc cattcttact acgctaaaga 300   
agaaataatt attcgaggat atttgcctgg cccagaagaa acttatgtaa atttcatgaa 360   
ctattatatc cgttttcctc ggagtgagag aaaactcttt ttagatatca tctgagagaa 420   
ctagtgaatc ccagtcactg agtggagttg agagtctaag aacctctgaa atttgagaac 480   
tgctggacca gagcctttag agctctgata aggtgtcaac agggtagtta atttggcacc 540   
atggggatac agggattgct acaatttatc aaagaagctt cagaacccat ccatgtgagg 600   
aagtataaag ggcaggtagt agctgtggat acatattgct ggcttcacaa aggagctatt 660   
gcttgtgctg aaaaactagc caaaggtgaa cctactgata ggtatgtagg attttgtatg 720   
aaatttgtaa atatgttact atctcatggg atcaagccta ttctcgtatt tgatggatgt 780   
actttacctt ctaaaaagga agtagagaga tctagaagag aaagacgaca agccaatctt 840   
cttaagggaa agcaacttct tcgtgagggg aaagtctcgg aagctcgaga gtgtttcacc 900   
cggtctatca atatcacaca tgccatggcc cacaaagtaa ttaaagctgc ccggtctcag 960   
ggggtagatt gcctcgtggc tccctatgaa gctgatgcgc agttggccta tcttaacaaa 1020  
gcgggaattg tgcaagccat aattacagag gactcggatc tcctagcttt tggctgtaaa 1080  
aaggtaattt taaagatgga ccagtttgga aatggacttg aaattgatca agctcggcta 1140  
ggaatgtgca gacagcttgg ggatgtattc acggaagaga agtttcgtta catgtgtatt 1200  
ctttcaggtt gtgactacct gtcatcactg cgtgggattg gattagcaaa ggcatgcaaa 1260  
gtcctaagac tagccaataa tccagatata gtaaaggtta tcaagaaaat tggacattat 1320  
ctcaagatga atatcacggt accagaggat tacatcaacg ggtttattcg ggccaacaat 1380  
accttcctct atcagctagt ttttgatccc atcaaaagga aacttattcc tctgaacgcc 1440  
tatgaagatg atgttgatcc tgaaacacta agctacgctg ggcaatatgt tgatgattcc 1500  
atagctcttc aaatagcact tggaaataaa gatataaata cttttgaaca gatcgatgac 1560  
tacaatccag acactgctat gcctgcccat tcaagaagtc atagttggga tgacaaaaca 1620  
tgtcaaaagt cagctaatgt tagcagcatt tggcatagga attactctcc cagaccagag 1680  
tcgggtactg tttcagatgc cccacaattg aaggaaaatc caagtactgt gggagtggaa 1740  
cgagtgatta gtactaaagg gttaaatctc ccaaggaaat catccattgt gaaaagacca 1800  
agaagtgcag agctgtcaga agatgacctg ttgagtcagt attctctttc atttacgaag 1860  
aagaccaaga aaaatagctc tgaaggcaat aaatcattga gcttttctga agtgtttgtg 1920  
cctgacctgg taaatggacc tactaacaaa aagagtgtaa gcactccacc taggacgaga 1980  
aataaatttg caacattttt acaaaggaaa aatgaagaaa gtggtgcagt tgtggttcca 2040  
gggaccagaa gcaggttttt ttgcagttca gattctactg actgtgtatc aaacaaagtg 2100  
agcatccagc ctctggatga aactgctgtc acagataaag agaacaatct gcatgaatca 2160  
gagtatggag accaagaagg caagagactg gttgacacag atgtagcacg taattcaagt 2220  
gatgacattc cgaataatca tattccaggt gatcatattc cagacaaggc aacagtgttt 2280  
acagatgaag agtcctactc ttttgagagc agcaaattta caaggaccat ttcaccaccc 2340  
actttgggaa cactaagaag ttgttttagt tggtctggag gtcttggaga tttttcaaga 2400  
acgccgagcc cctctccaag cacagcattg cagcagttcc gaagaaagag cgattccccc 2460  
acctctttgc ctgagaataa tatgtctgat gtgtcgcagt taaagagcga ggagtccagt 2520  
gacgatgagt ctcatccctt acgagaaggg gcatgttctt cacagtccca ggaaagtgga 2580  
gaattctcac tgcagagttc aaatgcatca aagctttctc agtgctctag taaggactct 2640  
gattcagagg aatctgattg caatattaag ttacttgaca gtcaaagtga ccagacctcc 2700  
aagctatgtt tatctcattt ctcaaaaaaa gacacacctc taaggaacaa ggttcctggg 2760  
ctatataagt ccagttctgc agactctctt tctacaacca agatcaaacc tctaggacct 2820  
gccagagcca gtgggctgag caagaagccg gcaagcatcc agaagagaaa gcatcataat 2880  
gccgagaaca agccggggtt acagatcaaa ctcaatgagc tctggaaaaa ctttggattt 2940  
aaaaaagatt ctgaaaagct tcctccttgt aagaaacccc tgtccccagt cagagataac 3000  
atccaactaa ctccagaagc ggaagaggat atatttaaca aacctgaatg tggccgtgtt 3060  
caaagagcaa tattccagta aatgcagact gctgcaaagc ttttgcctgc aagagaatct 3120  
gatcaatttg aagtccctgt ttgggaatga ggcacttatc agcatgaaga attttttctc 3180  
attctgtgcc attttaaaaa tagaatacat tttgtatatt aactttaaaa aaaaaaaaaa 3240  
aaaaa                                                             3245  


<210> 3
<211> 3138
<212> DNA
<213> Homo sapiens

<400> 3
cccgtgttct gcgttgccgg ccgtgggtgc tctggccaca gtgagttagg ggcgtcggag 60    
cgggtttctc caaccgcaat cggctccgct caaggggagg aggagagtcc cttctcggaa 120   
ggcctaagga aacgtgtcgt ctggaatggg cttgggggcc acgcctgcac atctccgcga 180   
gacagaggga taaagtgaag atggtgctgt tattgttacc tcgagtgcca catgcgacct 240   
ctgagatatg tacacagtca ttcttactat cgcactcagc cattcttact acgctaaaga 300   
agaaataatt attcgaggat atttgcctgg cccagaagaa acttatgtaa atttcatgaa 360   
ctattatatc cgttttcctc ggagtgagag aaaactcttt ttagatatca tctgagaggt 420   
agttaatttg gcaccatggg gatacaggga ttgctacaat ttatcaaaga agcttcagaa 480   
cccatccatg tgaggaagta taaagggcag gtagtagctg tggatacata ttgctggctt 540   
cacaaaggag ctattgcttg tgctgaaaaa ctagccaaag gtgaacctac tgataggtat 600   
gtaggatttt gtatgaaatt tgtaaatatg ttactatctc atgggatcaa gcctattctc 660   
gtatttgatg gatgtacttt accttctaaa aaggaagtag agagatctag aagagaaaga 720   
cgacaagcca atcttcttaa gggaaagcaa cttcttcgtg aggggaaagt ctcggaagct 780   
cgagagtgtt tcacccggtc tatcaatatc acacatgcca tggcccacaa agtaattaaa 840   
gctgcccggt ctcagggggt agattgcctc gtggctccct atgaagctga tgcgcagttg 900   
gcctatctta acaaagcggg aattgtgcaa gccataatta cagaggactc ggatctccta 960   
gcttttggct gtaaaaaggt aattttaaag atggaccagt ttggaaatgg acttgaaatt 1020  
gatcaagctc ggctaggaat gtgcagacag cttggggatg tattcacgga agagaagttt 1080  
cgttacatgt gtattctttc aggttgtgac tacctgtcat cactgcgtgg gattggatta 1140  
gcaaaggcat gcaaagtcct aagactagcc aataatccag atatagtaaa ggttatcaag 1200  
aaaattggac attatctcaa gatgaatatc acggtaccag aggattacat caacgggttt 1260  
attcgggcca acaatacctt cctctatcag ctagtttttg atcccatcaa aaggaaactt 1320  
attcctctga acgcctatga agatgatgtt gatcctgaaa cactaagcta cgctgggcaa 1380  
tatgttgatg attccatagc tcttcaaata gcacttggaa ataaagatat aaatactttt 1440  
gaacagatcg atgactacaa tccagacact gctatgcctg cccattcaag aagtcatagt 1500  
tgggatgaca aaacatgtca aaagtcagct aatgttagca gcatttggca taggaattac 1560  
tctcccagac cagagtcggg tactgtttca gatgccccac aattgaagga aaatccaagt 1620  
actgtgggag tggaacgagt gattagtact aaagggttaa atctcccaag gaaatcatcc 1680  
attgtgaaaa gaccaagaag tgcagagctg tcagaagatg acctgttgag tcagtattct 1740  
ctttcattta cgaagaagac caagaaaaat agctctgaag gcaataaatc attgagcttt 1800  
tctgaagtgt ttgtgcctga cctggtaaat ggacctacta acaaaaagag tgtaagcact 1860  
ccacctagga cgagaaataa atttgcaaca tttttacaaa ggaaaaatga agaaagtggt 1920  
gcagttgtgg ttccagggac cagaagcagg tttttttgca gttcagattc tactgactgt 1980  
gtatcaaaca aagtgagcat ccagcctctg gatgaaactg ctgtcacaga taaagagaac 2040  
aatctgcatg aatcagagta tggagaccaa gaaggcaaga gactggttga cacagatgta 2100  
gcacgtaatt caagtgatga cattccgaat aatcatattc caggtgatca tattccagac 2160  
aaggcaacag tgtttacaga tgaagagtcc tactcttttg agagcagcaa atttacaagg 2220  
accatttcac cacccacttt gggaacacta agaagttgtt ttagttggtc tggaggtctt 2280  
ggagattttt caagaacgcc gagcccctct ccaagcacag cattgcagca gttccgaaga 2340  
aagagcgatt cccccacctc tttgcctgag aataatatgt ctgatgtgtc gcagttaaag 2400  
agcgaggagt ccagtgacga tgagtctcat cccttacgag aaggggcatg ttcttcacag 2460  
tcccaggaaa gtggagaatt ctcactgcag agttcaaatg catcaaagct ttctcagtgc 2520  
tctagtaagg actctgattc agaggaatct gattgcaata ttaagttact tgacagtcaa 2580  
agtgaccaga cctccaagct atgtttatct catttctcaa aaaaagacac acctctaagg 2640  
aacaaggttc ctgggctata taagtccagt tctgcagact ctctttctac aaccaagatc 2700  
aaacctctag gacctgccag agccagtggg ctgagcaaga agccggcaag catccagaag 2760  
agaaagcatc ataatgccga gaacaagccg gggttacaga tcaaactcaa tgagctctgg 2820  
aaaaactttg gatttaaaaa attctgaaaa gcttcctcct tgtaagaaac ccctgtcccc 2880  
agtcagagat aacatccaac taactccaga agcggaagag gatatattta acaaacctga 2940  
atgtggccgt gttcaaagag caatattcca gtaaatgcag actgctgcaa agcttttgcc 3000  
tgcaagagaa tctgatcaat ttgaagtccc tgtttgggaa tgaggcactt atcagcatga 3060  
agaatttttt ctcattctgt gccattttaa aaatagaata cattttgtat attaacttta 3120  
aaaaaaaaaa aaaaaaaa                                               3138  


<210> 4
<211> 401
<212> PRT
<213> Mus musculus

<400> 4
Ser Lys Lys Ile Lys Glu Asn Gly Cys Gly Asp Gly Thr Ser Pro Asn  
  1               5                  10                  15    

Ser Ser Lys Met Ser Lys Ser Cys Pro Asp Ser Gly Thr Ala His Lys  
             20                  25                  30        

Thr Asp Ala His Thr Pro Ser Lys Met Arg Asn Lys Phe Ala Thr Phe  
         35                  40                  45            

Leu Gln Arg Arg Asn Glu Glu Ser Gly Ala Val Val Val Pro Gly Thr  
     50                  55                  60                

Arg Ser Arg Phe Phe Cys Ser Ser Gln Asp Phe Asp Asn Phe Ile Pro  
 65                  70                  75                  80

Lys Lys Glu Ser Gly Gln Pro Leu Asn Glu Thr Val Ala Thr Gly Lys  
                 85                  90                  95    

Ala Thr Thr Ser Leu Leu Gly Ala Leu Asp Cys Pro Asp Thr Glu Gly  
            100                 105                 110        

His Lys Pro Val Asp Ala Asn Gly Thr His Asn Leu Ser Ser Gln Ile  
        115                 120                 125            

Pro Gly Asn Ala Ala Val Ser Pro Glu Asp Glu Ala Gln Ser Ser Glu  
    130                 135                 140                

Thr Ser Lys Leu Leu Gly Ala Met Ser Pro Pro Ser Leu Gly Thr Leu  
145                 150                 155                 160

Arg Ser Cys Phe Ser Trp Ser Gly Thr Leu Arg Glu Phe Ser Arg Thr  
                165                 170                 175    

Pro Ser Pro Ser Ala Ser Thr Thr Leu Gln Gln Phe Arg Arg Lys Ser  
            180                 185                 190        

Asp Pro Pro Ala Cys Leu Pro Glu Ala Ser Ala Val Val Thr Asp Arg  
        195                 200                 205            

Cys Asp Ser Lys Ser Glu Met Leu Gly Glu Thr Ser Gln Pro Leu His  
    210                 215                 220                

Glu Leu Gly Cys Ser Ser Arg Ser Gln Glu Ser Met Asp Ser Ser Cys  
225                 230                 235                 240

Gly Leu Asn Thr Ser Ser Leu Ser Gln Pro Ser Ser Arg Asp Ser Gly  
                245                 250                 255    

Ser Glu Glu Ser Asp Cys Asn Asn Lys Ser Leu Asp Asn Gln Gly Glu  
            260                 265                 270        

Gln Asn Ser Lys Gln His Leu Pro His Phe Ser Lys Lys Asp Gly Leu  
        275                 280                 285            

Arg Arg Asn Lys Val Pro Gly Leu Cys Arg Ser Ser Ser Met Asp Ser  
    290                 295                 300                

Phe Ser Thr Thr Lys Ile Lys Pro Leu Val Pro Ala Arg Val Ser Gly  
305                 310                 315                 320

Leu Ser Lys Lys Ser Gly Ser Met Gln Thr Arg Lys His His Asp Val  
                325                 330                 335    

Glu Asn Lys Pro Gly Leu Gln Thr Lys Ile Ser Glu Leu Trp Lys Asn  
            340                 345                 350        

Phe Gly Phe Lys Lys Asp Ser Glu Lys Leu Pro Ser Cys Lys Lys Pro  
        355                 360                 365            

Leu Ser Pro Val Lys Asp Asn Ile Gln Leu Thr Pro Glu Thr Glu Asp  
    370                 375                 380                

Glu Ile Phe Asn Lys Pro Glu Cys Val Arg Ala Gln Arg Ala Ile Phe  
385                 390                 395                 400

His                                                              
   


<210> 5
<211> 837
<212> PRT
<213> Mus musculus

<400> 5
Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Gln Glu Ala Ser Glu Pro  
  1               5                  10                  15    

Val Asn Val Lys Lys Tyr Lys Gly Gln Ala Val Ala Val Asp Thr Tyr  
             20                  25                  30        

Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys  
         35                  40                  45            

Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn  
     50                  55                  60                

Met Leu Leu Ser Tyr Gly Val Lys Pro Ile Leu Ile Phe Asp Gly Cys  
 65                  70                  75                  80

Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg  
                 85                  90                  95    

Gln Ser Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val  
            100                 105                 110        

Ser Glu Ala Arg Asp Cys Phe Ala Arg Ser Ile Asn Ile Thr His Ala  
        115                 120                 125            

Met Ala His Lys Val Ile Lys Ala Ala Arg Ala Leu Gly Val Asp Cys  
    130                 135                 140                

Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys  
145                 150                 155                 160

Ala Gly Ile Val Gln Ala Val Ile Thr Glu Asp Ser Asp Leu Leu Ala  
                165                 170                 175    

Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly  
            180                 185                 190        

Leu Glu Val Asp Gln Ala Arg Leu Gly Met Cys Lys Gln Leu Gly Asp  
        195                 200                 205            

Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys  
    210                 215                 220                

Asp Tyr Leu Ala Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys  
225                 230                 235                 240

Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys  
                245                 250                 255    

Ile Gly His Tyr Leu Arg Met Asn Ile Thr Val Pro Glu Asp Tyr Ile  
            260                 265                 270        

Thr Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe  
        275                 280                 285            

Asp Pro Ile Gln Arg Lys Leu Val Pro Leu Asn Ala Tyr Gly Asp Asp  
    290                 295                 300                

Val Asn Pro Glu Thr Leu Thr Tyr Ala Gly Gln Tyr Val Gly Asp Ser  
305                 310                 315                 320

Val Ala Leu Gln Ile Ala Leu Gly Asn Arg Asp Val Asn Thr Phe Glu  
                325                 330                 335    

Gln Ile Asp Asp Tyr Ser Pro Asp Thr Met Pro Ala His Ser Arg Ser  
            340                 345                 350        

His Ser Trp Asn Glu Lys Ala Gly Gln Lys Pro Pro Gly Thr Asn Ser  
        355                 360                 365            

Ile Trp His Lys Asn Tyr Cys Pro Arg Leu Glu Val Asn Ser Val Ser  
    370                 375                 380                

His Ala Pro Gln Leu Lys Glu Lys Pro Ser Thr Leu Gly Leu Lys Gln  
385                 390                 395                 400

Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Cys Val Leu  
                405                 410                 415    

Lys Arg Pro Arg Asn Glu Ala Leu Ala Glu Asp Asp Leu Leu Ser Gln  
            420                 425                 430        

Tyr Ser Ser Val Ser Lys Lys Ile Lys Glu Asn Gly Cys Gly Asp Gly  
        435                 440                 445            

Thr Ser Pro Asn Ser Ser Lys Met Ser Lys Ser Cys Pro Asp Ser Gly  
    450                 455                 460                

Thr Ala His Lys Thr Asp Ala His Thr Pro Ser Lys Met Arg Asn Lys  
465                 470                 475                 480

Phe Ala Thr Phe Leu Gln Arg Arg Asn Glu Glu Ser Gly Ala Val Val  
                485                 490                 495    

Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Gln Asp Phe Asp  
            500                 505                 510        

Asn Phe Ile Pro Lys Lys Glu Ser Gly Gln Pro Leu Asn Glu Thr Val  
        515                 520                 525            

Ala Thr Gly Lys Ala Thr Thr Ser Leu Leu Gly Ala Leu Asp Cys Pro  
    530                 535                 540                

Asp Thr Glu Gly His Lys Pro Val Asp Ala Asn Gly Thr His Asn Leu  
545                 550                 555                 560

Ser Ser Gln Ile Pro Gly Asn Ala Ala Val Ser Pro Glu Asp Glu Ala  
                565                 570                 575    

Gln Ser Ser Glu Thr Ser Lys Leu Leu Gly Ala Met Ser Pro Pro Ser  
            580                 585                 590        

Leu Gly Thr Leu Arg Ser Cys Phe Ser Trp Ser Gly Thr Leu Arg Glu  
        595                 600                 605            

Phe Ser Arg Thr Pro Ser Pro Ser Ala Ser Thr Thr Leu Gln Gln Phe  
    610                 615                 620                

Arg Arg Lys Ser Asp Pro Pro Ala Cys Leu Pro Glu Ala Ser Ala Val  
625                 630                 635                 640

Val Thr Asp Arg Cys Asp Ser Lys Ser Glu Met Leu Gly Glu Thr Ser  
                645                 650                 655    

Gln Pro Leu His Glu Leu Gly Cys Ser Ser Arg Ser Gln Glu Ser Met  
            660                 665                 670        

Asp Ser Ser Cys Gly Leu Asn Thr Ser Ser Leu Ser Gln Pro Ser Ser  
        675                 680                 685            

Arg Asp Ser Gly Ser Glu Glu Ser Asp Cys Asn Asn Lys Ser Leu Asp  
    690                 695                 700                

Asn Gln Gly Glu Gln Asn Ser Lys Gln His Leu Pro His Phe Ser Lys  
705                 710                 715                 720

Lys Asp Gly Leu Arg Arg Asn Lys Val Pro Gly Leu Cys Arg Ser Ser  
                725                 730                 735    

Ser Met Asp Ser Phe Ser Thr Thr Lys Ile Lys Pro Leu Val Pro Ala  
            740                 745                 750        

Arg Val Ser Gly Leu Ser Lys Lys Ser Gly Ser Met Gln Thr Arg Lys  
        755                 760                 765            

His His Asp Val Glu Asn Lys Pro Gly Leu Gln Thr Lys Ile Ser Glu  
    770                 775                 780                

Leu Trp Lys Asn Phe Gly Phe Lys Lys Asp Ser Glu Lys Leu Pro Ser  
785                 790                 795                 800

Cys Lys Lys Pro Leu Ser Pro Val Lys Asp Asn Ile Gln Leu Thr Pro  
                805                 810                 815    

Glu Thr Glu Asp Glu Ile Phe Asn Lys Pro Glu Cys Val Arg Ala Gln  
            820                 825                 830        

Arg Ala Ile Phe His                                              
        835        


<210> 6
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Gly Gly Gly Gly Cys                                              
  1               5


