                         SEQUENCE LISTING

<110>  Firmenich SA
 
<120>  Modified 13-Hydroperoxidase lyases and uses thereof

<130>  F 8555 / RN

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  457
<212>  PRT
<213>  Psidium guajava


<220>
<221>  13-hydroperoxide lyase from Psidium guajava
<222>  (1)..(457)

<400>  1

Leu Pro Val Arg Thr Ile Pro Gly Ser Tyr Gly Trp Pro Leu Leu Gly 
1               5                   10                  15      


Pro Ile Ser Asp Arg Leu Asp Tyr Phe Trp Phe Gln Gly Pro Glu Thr 
            20                  25                  30          


Phe Phe Arg Lys Arg Ile Glu Lys Tyr Lys Ser Thr Val Phe Arg Ala 
        35                  40                  45              


Asn Val Pro Pro Cys Phe Pro Phe Phe Ser Asn Val Asn Pro Asn Val 
    50                  55                  60                  


Val Val Val Leu Asp Cys Glu Ser Phe Ala His Leu Phe Asp Met Glu 
65                  70                  75                  80  


Ile Val Glu Lys Ser Asn Val Leu Val Gly Asp Phe Met Pro Ser Val 
                85                  90                  95      


Lys Tyr Thr Gly Asn Ile Arg Val Cys Ala Tyr Leu Asp Thr Ser Glu 
            100                 105                 110         


Pro Gln His Ala Gln Val Lys Asn Phe Ala Met Asp Ile Leu Lys Arg 
        115                 120                 125             


Ser Ser Lys Val Trp Glu Ser Glu Val Ile Ser Asn Leu Asp Thr Met 
    130                 135                 140                 


Trp Asp Thr Ile Glu Ser Ser Leu Ala Lys Asp Gly Asn Ala Ser Val 
145                 150                 155                 160 


Ile Phe Pro Leu Gln Lys Phe Leu Phe Asn Phe Leu Ser Lys Ser Ile 
                165                 170                 175     


Ile Gly Ala Asp Pro Ala Ala Ser Pro Gln Val Ala Lys Ser Gly Tyr 
            180                 185                 190         


Ala Met Leu Asp Arg Trp Leu Ala Leu Gln Leu Leu Pro Thr Ile Asn 
        195                 200                 205             


Ile Gly Val Leu Gln Pro Leu Val Glu Ile Phe Leu His Ser Trp Ala 
    210                 215                 220                 


Tyr Pro Phe Ala Leu Val Ser Gly Asp Tyr Asn Lys Leu Tyr Gln Phe 
225                 230                 235                 240 


Ile Glu Lys Glu Gly Arg Glu Ala Val Glu Arg Ala Lys Ala Glu Phe 
                245                 250                 255     


Gly Leu Thr His Gln Glu Ala Ile His Asn Leu Leu Phe Ile Leu Gly 
            260                 265                 270         


Phe Asn Ala Phe Gly Gly Phe Ser Ile Phe Leu Pro Thr Leu Leu Ser 
        275                 280                 285             


Asn Ile Leu Ser Asp Thr Thr Gly Leu Gln Asp Arg Leu Arg Lys Glu 
    290                 295                 300                 


Val Arg Ala Lys Gly Gly Pro Ala Leu Ser Phe Ala Ser Val Lys Glu 
305                 310                 315                 320 


Met Glu Leu Val Lys Ser Val Val Tyr Glu Thr Leu Arg Leu Asn Pro 
                325                 330                 335     


Pro Val Pro Phe Gln Tyr Ala Arg Ala Arg Lys Asp Phe Gln Leu Lys 
            340                 345                 350         


Ser His Asp Ser Val Phe Asp Val Lys Lys Gly Glu Leu Leu Cys Gly 
        355                 360                 365             


Tyr Gln Lys Val Val Met Thr Asp Pro Lys Val Phe Asp Glu Pro Glu 
    370                 375                 380                 


Ser Phe Asn Ser Asp Arg Phe Val Gln Asn Ser Glu Leu Leu Asp Tyr 
385                 390                 395                 400 


Leu Tyr Trp Ser Asn Gly Pro Gln Thr Gly Thr Pro Thr Glu Ser Asn 
                405                 410                 415     


Lys Gln Cys Ala Ala Lys Asp Tyr Val Thr Leu Thr Ala Cys Leu Phe 
            420                 425                 430         


Val Ala Tyr Met Phe Arg Arg Tyr Asn Ser Val Thr Gly Ser Ser Ser 
        435                 440                 445             


Ser Ile Thr Ala Val Glu Lys Ala Asn 
    450                 455         


<210>  2
<211>  468
<212>  PRT
<213>  Artificial

<220>
<223>  SH34GC7

<400>  2

Ala Thr Pro Ser Ser Ser Ser Pro Glu Leu Pro Leu Lys Pro Ile Pro 
1               5                   10                  15      


Gly Ser Tyr Gly Trp Pro Leu Leu Gly Pro Ile Leu Asp Arg Leu Asp 
            20                  25                  30          


Tyr Phe Trp Phe Gln Gly Pro Glu Thr Phe Phe Arg Lys Arg Ile Glu 
        35                  40                  45              


Lys Tyr Lys Ser Thr Val Phe Arg Ala Asn Val Pro Pro Cys Phe Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Asn Pro Asn Val Val Val Val Leu Asp Cys Glu 
65                  70                  75                  80  


Ser Phe Ala His Leu Phe Asp Met Glu Ile Val Glu Lys Ser Asn Val 
                85                  90                  95      


Leu Val Gly Asp Phe Met Pro Ser Val Lys Tyr Thr Gly Asn Ile Arg 
            100                 105                 110         


Val Cys Ala Tyr Leu Asp Thr Ser Glu Pro Gln His Ala Gln Val Lys 
        115                 120                 125             


Asn Phe Ala Met Asp Ile Leu Lys Arg Ser Ser Lys Val Trp Glu Ser 
    130                 135                 140                 


Glu Val Ile Ser Asn Leu Asp Thr Met Trp Asp Thr Ile Glu Ser Ser 
145                 150                 155                 160 


Leu Ala Lys Asp Gly Asn Ala Ser Val Ile Phe Pro Leu Gln Lys Phe 
                165                 170                 175     


Leu Phe Asn Phe Leu Ser Lys Ser Ile Ile Gly Ala Asp Pro Ala Ala 
            180                 185                 190         


Ser Pro Gln Val Ala Lys Ser Gly Tyr Ala Met Leu Asp Arg Trp Leu 
        195                 200                 205             


Ala Leu Gln Leu Leu Pro Thr Ile His Ile Gly Val Leu Gln Pro Leu 
    210                 215                 220                 


Val Glu Ile Phe Leu His Ser Trp Ala Tyr Pro Phe Ala Leu Val Ser 
225                 230                 235                 240 


Gly Asp Tyr Asn Lys Leu Tyr Gln Phe Ile Glu Lys Glu Gly Arg Glu 
                245                 250                 255     


Ala Val Glu Arg Ala Lys Ala Glu Phe Gly Leu Thr His Gln Glu Ala 
            260                 265                 270         


Ile His Asn Leu Leu Phe Ile Leu Gly Phe Asn Ala Phe Gly Gly Phe 
        275                 280                 285             


Ser Ile Phe Leu Pro Thr Leu Leu Ser Asn Ile Leu Ser Asp Thr Thr 
    290                 295                 300                 


Gly Leu Gln Asp Arg Leu Arg Lys Glu Val Arg Ala Lys Gly Gly Pro 
305                 310                 315                 320 


Ala Leu Ser Phe Ala Ser Val Lys Glu Met Glu Leu Val Lys Ser Val 
                325                 330                 335     


Val Tyr Glu Thr Leu Arg Leu Asn Pro Pro Val Pro Leu Gln Tyr Ala 
            340                 345                 350         


Arg Ala Arg Lys Asp Phe Gln Leu Lys Ser His Asp Ser Val Phe Asp 
        355                 360                 365             


Ile Lys Lys Gly Glu Leu Leu Cys Gly Tyr Gln Pro Leu Val Met Arg 
    370                 375                 380                 


Asp Ser Lys Val Phe Asp Asp Ala Glu Ser Phe Lys Ala Glu Arg Phe 
385                 390                 395                 400 


Met Gly Glu Lys Gly Ser Glu Leu Leu Ser Tyr Leu Tyr Trp Ser Asn 
                405                 410                 415     


Gly Pro Gln Thr Gly Thr Pro Thr Glu Ser Asn Lys Gln Cys Ala Ala 
            420                 425                 430         


Lys Asp Tyr Val Thr Leu Thr Ala Cys Leu Phe Val Ala Tyr Met Phe 
        435                 440                 445             


Arg Arg Tyr Asn Ser Val Thr Gly Ser Ser Ser Ser Ile Thr Ala Val 
    450                 455                 460                 


Glu Lys Ala Lys 
465             


<210>  3
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  SH34GC7

<400>  3
gctactcctt cttcctcctc ccctgaactc ccgctgaaac cgatcccggg cagctacggg       60

tggcccctcc tcggcccgat attggaccgc ctggactact tctggttcca aggcccggag      120

acgttcttca ggaagaggat cgagaagtac aagagcaccg tgttccgcgc gaacgtgcct      180

ccgtgcttcc ccttcttctc gaacgtgaac cctaacgtcg tggtcgtcct cgattgcgag      240

tccttcgctc acttgttcga catggagatc gtggagaaga gcaacgtcct cgtcggcgac      300

ttcatgccga gcgtgaagta caccgggaac atccgggtct gcgcttacct cgacacttcc      360

gagcctcaac acgctcaggt gaagaacttt gcgatggaca tactgaagag gagctccaaa      420

gtgtgggaga gcgaagtgat ctcgaacttg gacaccatgt gggacaccat cgagtccagc      480

ctcgccaagg acggcaacgc cagcgtcatc ttccctctcc aaaagttcct cttcaacttc      540

ctctccaagt ccatcatcgg cgctgacccg gccgcctcgc cgcaggtggc caagtccggc      600

tacgccatgc ttgaccggtg gctcgctctc cagctcctcc ccaccatcca cattggcgta      660

ctgcagcctc tagtggagat ttttctgcat tcttgggcat acccttttgc gctggtgagc      720

ggggactaca acaagctcta ccagttcatc gagaaggaag gccgagaagc ggtcgaaagg      780

gcgaaggccg agttcggatt gacacaccag gaggccatcc acaacttgct gttcatcctc      840

ggcttcaacg cgttcggcgg cttctcgatc ttcctcccca cgttgctgag caacatactt      900

agcgacacaa ccggactgca ggaccggctg aggaaggagg tccgggcaaa gggagggccg      960

gcgttgagct tcgcctcggt gaaggagatg gaactcgtga agtcggtcgt gtacgagacg     1020

ctgcggctca acccgcccgt cccgctccaa tacgctcgag cccggaagga cttccagctc     1080

aagtcccacg actctgtctt tgatatcaag aaaggcgagc tgctatgcgg gtatcagcct     1140

ttggtcatga gggattcgaa ggtgtttgac gatgctgaga gttttaaggc tgagaggttt     1200

atgggcgaaa agggcagcga gctactgagt tacctgtact ggtccaacgg gccgcagacc     1260

ggaacgccga ccgagtcgaa caagcagtgc gcggctaagg actacgtcac cctcaccgct     1320

tgtctcttcg ttgcctacat gtttcgacgg tacaattccg tcacaggaag ctcgagctcg     1380

atcacagccg ttgaaaaggc caagtga                                         1407


<210>  4
<211>  468
<212>  PRT
<213>  Artificial

<220>
<223>  SH34E8B

<400>  4

Ala Thr Pro Ser Ser Ser Ser Pro Glu Leu Pro Leu Lys Pro Ile Pro 
1               5                   10                  15      


Gly Ser Tyr Gly Trp Pro Leu Leu Gly Pro Ile Ser Asp Arg Leu Asp 
            20                  25                  30          


Tyr Phe Trp Phe Gln Gly Pro Glu Thr Phe Phe Arg Lys Arg Ile Glu 
        35                  40                  45              


Lys Tyr Lys Ser Thr Val Phe Arg Ala Asn Val Pro Pro Cys Phe Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Asn Pro Asn Val Val Val Val Leu Asp Cys Glu 
65                  70                  75                  80  


Ser Phe Ala His Leu Phe Asp Met Glu Ile Val Glu Lys Ser Asn Val 
                85                  90                  95      


Leu Val Gly Asp Phe Met Pro Ser Val Lys Tyr Thr Gly Asn Ile Arg 
            100                 105                 110         


Val Cys Ala Tyr Leu Asp Thr Ser Glu Pro Gln His Ala Gln Val Lys 
        115                 120                 125             


Asn Phe Ala Met Asp Ile Leu Lys Arg Ser Ser Lys Val Trp Glu Ser 
    130                 135                 140                 


Glu Val Ile Ser Asn Leu Asp Thr Met Trp Asp Thr Ile Glu Ser Ser 
145                 150                 155                 160 


Leu Ala Lys Asp Gly Asn Ala Ser Val Ile Phe Pro Leu Gln Lys Phe 
                165                 170                 175     


Leu Phe Asn Phe Leu Ser Lys Ser Ile Ile Gly Ala Asp Pro Ala Ala 
            180                 185                 190         


Ser Pro Gln Val Ala Lys Ser Gly Tyr Ala Met Leu Asp Arg Trp Leu 
        195                 200                 205             


Ala Leu Gln Leu Leu Pro Thr Ile His Ile Gly Val Leu Gln Pro Leu 
    210                 215                 220                 


Val Glu Ile Phe Leu His Ser Trp Ala Tyr Pro Phe Ala Leu Val Ser 
225                 230                 235                 240 


Gly Asp Tyr Asn Lys Leu Tyr Gln Phe Ile Glu Lys Glu Gly Arg Glu 
                245                 250                 255     


Ala Val Glu Arg Ala Lys Ala Glu Phe Gly Leu Thr His Gln Glu Ala 
            260                 265                 270         


Ile His Asn Leu Leu Phe Ile Leu Gly Phe Asn Ala Phe Gly Gly Phe 
        275                 280                 285             


Ser Ile Phe Leu Pro Thr Leu Leu Ser Asn Ile Leu Ser Asp Thr Thr 
    290                 295                 300                 


Gly Leu Gln Asp Arg Leu Arg Lys Glu Val Arg Ala Lys Gly Gly Pro 
305                 310                 315                 320 


Ala Leu Ser Phe Ala Ser Val Lys Glu Met Glu Leu Val Lys Ser Val 
                325                 330                 335     


Val Tyr Glu Thr Leu Arg Leu Asn Pro Pro Val Pro Leu Gln Tyr Ala 
            340                 345                 350         


Arg Ala Arg Lys Asp Phe Gln Leu Lys Ser His Asp Ser Val Phe Asp 
        355                 360                 365             


Val Lys Lys Gly Glu Leu Leu Cys Gly Tyr Gln Pro Leu Val Met Arg 
    370                 375                 380                 


Asp Ser Lys Val Phe Asp Asp Ala Glu Ser Phe Lys Ala Glu Arg Phe 
385                 390                 395                 400 


Met Gly Glu Lys Gly Ser Glu Leu Leu Ser Tyr Leu Tyr Trp Ser Asn 
                405                 410                 415     


Gly Pro Gln Thr Gly Thr Pro Thr Glu Ser Asn Lys Gln Cys Ala Ala 
            420                 425                 430         


Lys Asp Tyr Val Thr Leu Thr Ala Cys Leu Phe Val Ala Tyr Met Phe 
        435                 440                 445             


Arg Arg Tyr Asn Ser Val Thr Gly Ser Ser Ser Ser Ile Thr Ala Val 
    450                 455                 460                 


Glu Lys Ala Lys 
465             


<210>  5
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  SH34E8B

<400>  5
gctactcctt cttcctcctc ccctgaactc ccgctgaaac cgatcccggg cagctacggg       60

tggcccctcc tcggcccgat atcggaccgc ctggactact tctggttcca aggcccggag      120

acgttcttca ggaagaggat cgagaagtac aagagcaccg tgttccgcgc gaacgtgcct      180

ccgtgcttcc ccttcttctc gaacgtgaac cctaacgtcg tggtcgtcct cgattgcgag      240

tccttcgctc acttgttcga catggagatc gtggagaaga gcaacgtcct cgtcggcgac      300

ttcatgccga gcgtgaagta caccgggaac atccgggtct gcgcttacct cgacacttcc      360

gagcctcaac acgctcaggt gaagaacttt gcgatggaca tactgaagag gagctccaaa      420

gtgtgggaga gcgaagtgat ctcgaacttg gacaccatgt gggacaccat cgagtccagc      480

ctcgccaagg acggcaacgc cagcgtcatc ttccctctcc aaaagttcct cttcaacttc      540

ctctccaagt ccatcatcgg cgctgacccg gccgcctcgc cgcaggtggc caagtccggc      600

tacgccatgc ttgaccggtg gctcgctctc cagctcctcc ccaccatcca cattggcgta      660

ctgcagcctc tagtggagat ttttctgcat tcttgggcat acccttttgc gctggtgagc      720

ggggactaca acaagctcta ccagttcatc gagaaggaag gccgagaagc ggtcgaaagg      780

gcgaaggccg agttcggatt gacacaccag gaggccatcc acaacttgct gttcatcctc      840

ggcttcaacg cgttcggcgg cttctcgatc ttcctcccca cgttgctgag caacatactt      900

agcgacacaa ccggactgca ggaccggctg aggaaggagg tccgggcaaa gggagggccg      960

gcgttgagct tcgcctcggt gaaggagatg gaactcgtga agtcggtcgt gtacgagacg     1020

ctgcggctca acccgcccgt cccgctccaa tacgctcgag cccggaagga cttccagctc     1080

aagtcccacg actctgtctt tgatgtcaag aaaggcgagc tgctatgcgg gtatcagcct     1140

ttggtcatga gggattcgaa ggtgtttgac gatgctgaga gttttaaggc tgagaggttt     1200

atgggcgaaa agggcagcga gctactgagt tacctgtact ggtccaacgg gccgcagacc     1260

ggaacgccga ccgagtcgaa caagcagtgc gcggctaagg actacgtcac cctcaccgct     1320

tgtctcttcg ttgcctacat gtttcgacgg tacaattccg tcacaggaag ctcgagctcg     1380

atcacagccg ttgaaaaggc caagtga                                         1407


<210>  6
<211>  468
<212>  PRT
<213>  Artificial

<220>
<223>  SH33AC5

<400>  6

Ala Thr Pro Ser Ser Ser Ser Pro Glu Leu Pro Leu Lys Pro Ile Pro 
1               5                   10                  15      


Gly Ser Tyr Gly Trp Pro Leu Leu Gly Pro Ile Leu Asp Arg Leu Asp 
            20                  25                  30          


Tyr Phe Trp Phe Gln Gly Pro Glu Thr Phe Phe Arg Lys Arg Ile Glu 
        35                  40                  45              


Lys Tyr Lys Ser Thr Val Phe Arg Ala Asn Val Pro Pro Cys Phe Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Asn Pro Asn Val Val Val Val Leu Asp Cys Glu 
65                  70                  75                  80  


Ser Phe Ala His Leu Phe Asp Met Glu Ile Val Glu Lys Ser Asn Val 
                85                  90                  95      


Leu Val Gly Asp Phe Met Pro Ser Val Lys Tyr Thr Gly Asn Ile Arg 
            100                 105                 110         


Val Cys Ala Tyr Leu Asp Thr Ser Glu Pro Gln His Ala Gln Val Lys 
        115                 120                 125             


Asn Phe Ala Met Asp Ile Leu Lys Arg Ser Ser Lys Val Trp Glu Ser 
    130                 135                 140                 


Glu Val Ile Ser Asn Leu Asp Thr Met Trp Asp Thr Ile Glu Ser Ser 
145                 150                 155                 160 


Leu Ala Lys Asp Gly Asn Ala Ser Val Ile Phe Pro Leu Gln Lys Phe 
                165                 170                 175     


Leu Phe Asn Phe Leu Ser Lys Ser Ile Ile Gly Ala Asp Pro Ala Ala 
            180                 185                 190         


Ser Pro Gln Val Ala Lys Ser Gly Tyr Ala Met Leu Asp Arg Trp Leu 
        195                 200                 205             


Ala Leu Gln Leu Leu Pro Thr Ile His Ile Gly Val Leu Gln Pro Leu 
    210                 215                 220                 


Val Glu Ile Phe Leu His Ser Trp Ala Tyr Pro Phe Ala Leu Val Ser 
225                 230                 235                 240 


Gly Asp Tyr Asn Lys Leu Tyr Gln Phe Ile Glu Lys Glu Gly Arg Glu 
                245                 250                 255     


Ala Val Glu Arg Ala Lys Ala Glu Phe Gly Leu Thr His Gln Glu Ala 
            260                 265                 270         


Ile His Asn Leu Leu Phe Ile Leu Gly Phe Asn Ala Phe Gly Gly Phe 
        275                 280                 285             


Ser Ile Phe Leu Pro Thr Leu Leu Ser Asn Ile Leu Ser Asp Thr Thr 
    290                 295                 300                 


Gly Leu Gln Asp Arg Leu Arg Lys Glu Val Arg Ala Lys Gly Gly Pro 
305                 310                 315                 320 


Ala Leu Ser Phe Ala Ser Val Lys Glu Met Glu Leu Val Lys Ser Val 
                325                 330                 335     


Val Tyr Glu Thr Leu Arg Leu Asn Pro Pro Val Pro Leu Gln Phe Ala 
            340                 345                 350         


Arg Ala Arg Lys Asp Phe Gln Leu Arg Ser His Asp Ser Val Tyr Asp 
        355                 360                 365             


Ile Lys Lys Gly Glu Leu Leu Cys Gly Tyr Gln Pro Leu Val Met Arg 
    370                 375                 380                 


Asp Ser Lys Val Phe Asp Asp Ala Glu Ser Phe Lys Ala Glu Arg Phe 
385                 390                 395                 400 


Met Gly Glu Lys Gly Ser Glu Leu Leu Ser Tyr Leu Tyr Trp Ser Asn 
                405                 410                 415     


Gly Pro Gln Thr Gly Thr Pro Thr Glu Ser Asn Lys Gln Cys Ala Ala 
            420                 425                 430         


Lys Asp Tyr Val Thr Leu Thr Ala Cys Leu Phe Val Ala Tyr Met Phe 
        435                 440                 445             


Arg Arg Tyr Asn Ser Val Thr Gly Ser Ser Ser Ser Ile Thr Ala Val 
    450                 455                 460                 


Glu Lys Ala Lys 
465             


<210>  7
<211>  1409
<212>  DNA
<213>  Artificial

<220>
<223>  SH33AC5

<400>  7
acgctactcc ttcttcctcc tcccctgaac tcccgctgaa accgatcccg ggcagctacg       60

ggtggcccct cctcggcccg atattggacc gcctggacta cttctggttc caaggcccgg      120

agacgttctt caggaagagg atcgagaagt acaagagcac cgtgttccgc gcgaacgtgc      180

ctccgtgctt ccccttcttc tcgaacgtga accctaacgt cgtggtcgtc ctcgattgcg      240

agtccttcgc tcacttgttc gacatggaga tcgtggagaa gagcaacgtc ctcgtcggcg      300

acttcatgcc gagcgtgaag tacaccggga acatccgggt ctgcgcttac ctcgacactt      360

ccgagcctca acacgctcag gtgaagaact ttgcgatgga catactgaag aggagctcca      420

aagtgtggga gagcgaagtg atctcgaact tggacaccat gtgggacacc atcgagtcca      480

gcctcgccaa ggacggcaac gccagcgtca tcttccctct ccaaaagttc ctcttcaact      540

tcctctccaa gtccatcatc ggcgctgacc cggccgcctc gccgcaggtg gccaagtccg      600

gctacgccat gcttgaccgg tggctcgctc tccagctcct ccccaccatc cacattggcg      660

tactgcagcc tctagtggag atttttctgc attcttgggc ataccctttt gcgctggtga      720

gcggggacta caacaagctc taccagttca tcgagaagga aggccgagaa gcggtcgaaa      780

gggcgaaggc cgagttcgga ttgacacacc aggaggccat ccacaacttg ctgttcatcc      840

tcggcttcaa cgcgttcggc ggcttctcga tcttcctccc cacgttgctg agcaacatac      900

ttagcgacac aaccggactg caggaccggc tgaggaagga ggtccgggca aagggagggc      960

cggcgttgag cttcgcctcg gtgaaggaga tggaactcgt gaagtcggtc gtgtacgaga     1020

cgctgcggct caacccgccc gtcccgctcc agtttgctcg agcccggaag gacttccagc     1080

tcaggtcgca cgactcggtg tacgatatca agaaaggcga gctgctatgc gggtatcagc     1140

ctttggtcat gagggattcg aaggtgtttg acgatgctga gagttttaag gctgagaggt     1200

ttatgggcga aaagggcagc gagctactga gttacctgta ctggtccaac gggccgcaga     1260

ccggaacgcc gaccgagtcg aacaagcagt gcgcggctaa ggactacgtc accctcaccg     1320

cttgtctctt cgttgcctac atgtttcgac ggtacaattc cgtcacagga agctcgagct     1380

cgatcacagc cgttgaaaag gccaagtga                                       1409


<210>  8
<211>  468
<212>  PRT
<213>  Artificial

<220>
<223>  SH33C2A

<400>  8

Ala Thr Pro Ser Ser Ser Ser Pro Glu Leu Pro Leu Lys Pro Ile Pro 
1               5                   10                  15      


Gly Ser Tyr Gly Trp Pro Leu Leu Gly Pro Ile Ser Asp Arg Leu Asp 
            20                  25                  30          


Tyr Phe Trp Phe Gln Gly Pro Glu Thr Phe Phe Arg Lys Arg Ile Glu 
        35                  40                  45              


Lys Tyr Lys Ser Thr Val Phe Arg Ala Asn Val Pro Pro Cys Phe Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Asn Pro Asn Val Val Val Val Leu Asp Cys Glu 
65                  70                  75                  80  


Ser Phe Ala His Leu Phe Asp Met Glu Ile Val Glu Lys Ser Asn Val 
                85                  90                  95      


Leu Val Gly Asp Phe Met Pro Ser Val Lys Tyr Thr Gly Asn Ile Arg 
            100                 105                 110         


Val Cys Ala Tyr Leu Asp Thr Ser Glu Pro Gln His Ala Gln Val Lys 
        115                 120                 125             


Asn Phe Ala Met Asp Ile Leu Lys Arg Ser Ser Lys Val Trp Glu Ser 
    130                 135                 140                 


Glu Val Ile Ser Asn Leu Asp Thr Met Trp Asp Thr Ile Glu Ser Ser 
145                 150                 155                 160 


Leu Ala Lys Asp Gly Asn Ala Ser Val Ile Phe Pro Leu Gln Lys Phe 
                165                 170                 175     


Leu Phe Asn Phe Leu Ser Lys Ser Ile Ile Gly Ala Asp Pro Ala Ala 
            180                 185                 190         


Ser Pro Gln Val Ala Lys Ser Gly Tyr Ala Met Leu Asp Arg Trp Leu 
        195                 200                 205             


Ala Leu Gln Leu Leu Pro Thr Ile His Ile Gly Val Leu Gln Pro Leu 
    210                 215                 220                 


Val Glu Ile Phe Leu His Ser Trp Ala Tyr Pro Phe Ala Leu Val Ser 
225                 230                 235                 240 


Gly Asp Tyr Asn Lys Leu Tyr Gln Phe Ile Glu Lys Glu Gly Arg Glu 
                245                 250                 255     


Ala Val Glu Arg Ala Lys Ala Glu Phe Gly Leu Thr His Gln Glu Ala 
            260                 265                 270         


Ile His Asn Leu Leu Phe Ile Leu Gly Phe Asn Ala Phe Gly Gly Phe 
        275                 280                 285             


Ser Ile Phe Leu Pro Thr Leu Leu Ser Asn Ile Leu Ser Asp Thr Thr 
    290                 295                 300                 


Gly Leu Gln Asp Arg Leu Arg Lys Glu Val Arg Ala Lys Gly Gly Pro 
305                 310                 315                 320 


Ala Leu Ser Phe Ala Ser Val Lys Glu Met Glu Leu Val Lys Ser Val 
                325                 330                 335     


Val Tyr Glu Thr Leu Arg Leu Asn Pro Pro Val Pro Leu Gln Phe Ala 
            340                 345                 350         


Arg Ala Arg Lys Asp Phe Gln Leu Lys Ser His Asp Ser Val Tyr Glu 
        355                 360                 365             


Ile Lys Lys Gly Glu Leu Leu Cys Gly Tyr Gln Pro Leu Val Met Arg 
    370                 375                 380                 


Asp Ser Lys Val Phe Asp Asp Ala Glu Ser Phe Lys Ala Glu Arg Phe 
385                 390                 395                 400 


Met Gly Glu Lys Gly Ser Glu Leu Leu Ser Tyr Leu Tyr Trp Ser Asn 
                405                 410                 415     


Gly Pro Gln Thr Gly Thr Pro Thr Glu Ser Asn Lys Gln Cys Ala Ala 
            420                 425                 430         


Lys Asp Tyr Val Thr Leu Thr Ala Cys Leu Phe Val Ala Tyr Met Phe 
        435                 440                 445             


Arg Arg Tyr Asn Ser Val Thr Gly Ser Ser Ser Ser Ile Thr Ala Val 
    450                 455                 460                 


Glu Lys Ala Asn 
465             


<210>  9
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  SH33C2A

<400>  9
gctactcctt cttcctcctc ccctgaactc ccgctgaaac cgatcccggg cagctacggg       60

tggcccctcc tcggcccgat atcggaccgc ctggactact tctggttcca aggcccggag      120

acgttcttca ggaagaggat cgagaagtac aagagcaccg tgttccgcgc gaacgtgcct      180

ccgtgcttcc ccttcttctc gaacgtgaac cctaacgtcg tggtcgtcct cgattgcgag      240

tccttcgctc acttgttcga catggagatc gtggagaaga gcaacgtcct cgtcggcgac      300

ttcatgccga gcgtgaagta caccgggaac atccgggtct gcgcttacct cgacacttcc      360

gagcctcaac acgctcaggt gaagaacttt gcgatggaca tactgaagag gagctccaaa      420

gtgtgggaga gcgaagtgat ctcgaacttg gacaccatgt gggacaccat cgagtccagc      480

ctcgccaagg acggcaacgc cagcgtcatc ttccctctcc aaaagttcct cttcaacttc      540

ctctccaagt ccatcatcgg cgctgacccg gccgcctcgc cgcaggtggc caagtccggc      600

tacgccatgc ttgaccggtg gctcgctctc cagctcctcc ccaccatcca cattggcgta      660

ctgcagcctc tagtggagat ttttctgcat tcttgggcat acccttttgc gctggtgagc      720

ggggactaca acaagctcta ccagttcatc gagaaggaag gccgagaagc ggtcgaaagg      780

gcgaaggccg agttcggatt gacacaccag gaggccatcc acaacttgct gttcatcctc      840

ggcttcaacg cgttcggcgg cttctcgatc ttcctcccca cgttgctgag caacatactt      900

agcgacacaa ccggactgca ggaccggctg aggaaggagg tccgggcaaa gggagggccg      960

gcgttgagct tcgcctcggt gaaggagatg gaactcgtga agtcggtcgt gtacgagacg     1020

ctgcggctca acccgcccgt cccgctccag tttgctcgag cccggaagga cttccagctc     1080

aagtcccacg actctgtcta tgaaatcaag aaaggcgagc tgctatgcgg gtatcagcca     1140

ttggtgatga gggattcgaa ggtgtttgac gatgctgaga gttttaaggc tgagaggttt     1200

atgggcgaaa agggcagcga gctactgagt tacctgtact ggtccaacgg gccgcagacc     1260

ggaacgccga ccgagtcgaa caagcagtgc gcggctaagg actacgtcac cctcaccgct     1320

tgtctcttcg ttgcctacat gtttcgacgg tacaattccg tcacaggaag ctcgagctcg     1380

atcacagccg ttgaaaaggc caactga                                         1407


<210>  10
<211>  468
<212>  PRT
<213>  Artificial

<220>
<223>  SH33B7A

<400>  10

Ala Thr Pro Ser Ser Ser Ser Pro Glu Leu Pro Leu Lys Pro Ile Pro 
1               5                   10                  15      


Gly Ser Tyr Gly Trp Pro Leu Leu Gly Pro Ile Leu Asp Arg Leu Asp 
            20                  25                  30          


Tyr Phe Trp Phe Gln Gly Pro Glu Thr Phe Phe Arg Lys Arg Ile Glu 
        35                  40                  45              


Lys Tyr Lys Ser Thr Val Phe Arg Ala Asn Val Pro Pro Cys Phe Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Asn Pro Asn Val Val Val Val Leu Asp Cys Glu 
65                  70                  75                  80  


Ser Phe Ala His Leu Phe Asp Met Glu Ile Val Glu Lys Ser Asn Val 
                85                  90                  95      


Leu Val Gly Asp Phe Met Pro Ser Val Lys Tyr Thr Gly Asn Ile Arg 
            100                 105                 110         


Val Cys Ala Tyr Leu Asp Thr Ser Glu Pro Gln His Ala Gln Val Lys 
        115                 120                 125             


Asn Phe Ala Met Asp Ile Leu Lys Arg Ser Ser Lys Val Trp Glu Ser 
    130                 135                 140                 


Glu Val Ile Ser Asn Leu Asp Thr Met Trp Asp Thr Ile Glu Ser Ser 
145                 150                 155                 160 


Leu Ala Lys Asp Gly Asn Ala Ser Val Ile Phe Pro Leu Gln Lys Phe 
                165                 170                 175     


Leu Phe Asn Phe Leu Ser Lys Ser Ile Ile Gly Ala Asp Pro Ala Ala 
            180                 185                 190         


Ser Pro Gln Val Ala Lys Ser Gly Tyr Ala Met Leu Asp Arg Trp Leu 
        195                 200                 205             


Ala Leu Gln Leu Leu Pro Thr Ile His Ile Gly Val Leu Gln Pro Leu 
    210                 215                 220                 


Val Glu Ile Phe Leu His Ser Trp Ala Tyr Pro Phe Ala Leu Val Ser 
225                 230                 235                 240 


Gly Asp Tyr Asn Lys Leu Tyr Gln Phe Ile Glu Lys Glu Gly Arg Glu 
                245                 250                 255     


Ala Val Glu Arg Ala Lys Ala Glu Phe Gly Leu Thr His Gln Glu Ala 
            260                 265                 270         


Ile His Asn Leu Leu Phe Ile Leu Gly Phe Asn Ala Phe Gly Gly Phe 
        275                 280                 285             


Ser Ile Phe Leu Pro Thr Leu Leu Ser Asn Ile Leu Ser Asp Thr Thr 
    290                 295                 300                 


Gly Leu Gln Asp Arg Leu Arg Lys Glu Val Arg Ala Lys Gly Gly Pro 
305                 310                 315                 320 


Ala Leu Ser Phe Ala Ser Val Lys Glu Met Glu Leu Val Lys Ser Val 
                325                 330                 335     


Val Tyr Glu Thr Leu Arg Leu Asn Pro Pro Val Pro Phe Gln Tyr Ala 
            340                 345                 350         


Arg Ala Arg Lys Asp Phe Gln Leu Lys Ser His Asp Ser Val Tyr Asp 
        355                 360                 365             


Ile Lys Lys Gly Glu Leu Leu Cys Gly Tyr Gln Pro Leu Val Met Arg 
    370                 375                 380                 


Asp Ser Lys Val Phe Asp Asp Ala Glu Ser Phe Lys Ala Glu Arg Phe 
385                 390                 395                 400 


Met Gly Glu Lys Gly Ser Glu Leu Leu Ser Tyr Leu Tyr Trp Ser Asn 
                405                 410                 415     


Gly Pro Gln Thr Gly Thr Pro Thr Glu Ser Asn Lys Gln Cys Ala Ala 
            420                 425                 430         


Lys Asp Tyr Val Thr Leu Thr Ala Cys Leu Phe Val Ala Tyr Met Phe 
        435                 440                 445             


Arg Arg Tyr Asn Ser Val Thr Gly Ser Ser Ser Ser Ile Thr Ala Val 
    450                 455                 460                 


Glu Lys Ala Lys 
465             


<210>  11
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  SH33B7A

<400>  11
gctactcctt cttcctcctc ccctgaactc ccgctgaaac cgatcccggg cagctacggg       60

tggcccctcc tcggcccgat attggaccgc ctggactact tctggttcca aggcccggag      120

acgttcttca ggaagaggat cgagaagtac aagagcaccg tgttccgcgc gaacgtgcct      180

ccgtgcttcc ccttcttctc gaacgtgaac cctaacgtcg tggtcgtcct cgattgcgag      240

tccttcgctc acttgttcga catggagatc gtggagaaga gcaacgtcct cgtcggcgac      300

ttcatgccga gcgtgaagta caccgggaac atccgggtct gcgcttacct cgacacttcc      360

gagcctcaac acgctcaggt gaagaacttt gcgatggaca tactgaagag gagctccaaa      420

gtgtgggaga gcgaagtgat ctcgaacttg gacaccatgt gggacaccat cgagtccagc      480

ctcgccaagg acggcaacgc cagcgtcatc ttccctctcc aaaagttcct cttcaacttc      540

ctctccaagt ccatcatcgg cgctgacccg gccgcctcgc cgcaggtggc caagtccggc      600

tacgccatgc ttgaccggtg gctcgctctc cagctcctcc ccaccatcca cattggcgta      660

ctgcagcctc tagtggagat ttttctgcat tcttgggcat acccttttgc gctggtgagc      720

ggggactaca acaagctcta ccagttcatc gagaaggaag gccgagaagc ggtcgaaagg      780

gcgaaggccg agttcggatt gacacaccag gaggccatcc acaacttgct gttcatcctc      840

ggcttcaacg cgttcggcgg cttctcgatc ttcctcccca cgttgctgag caacatactt      900

agcgacacaa ccggactgca ggaccggctg aggaaggagg tccgggcaaa gggagggccg      960

gcgttgagct tcgcctcggt gaaggagatg gaactcgtga agtcggtcgt gtacgagacg     1020

ctgcggctca acccgcccgt cccgttccaa tacgctcgag cccggaagga cttccagctc     1080

aagtcccacg actcggtgta cgatatcaag aaaggcgagc tgctatgcgg gtatcagcct     1140

ttggtcatga gggattcgaa ggtgtttgac gatgctgaga gttttaaggc tgagaggttt     1200

atgggcgaaa agggcagcga gctactgagt tacctgtact ggtccaacgg gccgcagacc     1260

ggaacgccga ccgagtcgaa caagcagtgc gcggctaagg actacgtcac cctcaccgct     1320

tgtctcttcg ttgcctacat gtttcgacgg tacaattccg tcacaggaag ctcgagctcg     1380

atcacagccg ttgaaaaggc caagtga                                         1407


<210>  12
<211>  466
<212>  PRT
<213>  Artificial

<220>
<223>  variant of WT

<400>  12

Ala Thr Pro Ser Ser Ser Ser Pro Glu Leu Pro Leu Lys Pro Ile Pro 
1               5                   10                  15      


Gly Ser Tyr Gly Trp Pro Leu Leu Gly Pro Ile Ser Asp Arg Leu Asp 
            20                  25                  30          


Tyr Phe Trp Phe Gln Gly Pro Glu Thr Phe Phe Arg Lys Arg Ile Glu 
        35                  40                  45              


Lys Tyr Lys Ser Thr Val Phe Arg Ala Asn Val Pro Pro Cys Phe Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Asn Pro Asn Val Val Val Val Leu Asp Cys Glu 
65                  70                  75                  80  


Ser Phe Ala His Leu Phe Asp Met Glu Ile Val Glu Lys Ser Asn Val 
                85                  90                  95      


Leu Val Gly Asp Phe Met Pro Ser Val Lys Tyr Thr Gly Asn Ile Arg 
            100                 105                 110         


Val Cys Ala Tyr Leu Asp Thr Ser Glu Pro Gln His Ala Gln Val Lys 
        115                 120                 125             


Asn Phe Ala Met Asp Ile Leu Lys Arg Ser Ser Lys Val Trp Glu Ser 
    130                 135                 140                 


Glu Val Ile Ser Asn Leu Asp Thr Met Trp Asp Thr Ile Glu Ser Ser 
145                 150                 155                 160 


Leu Ala Lys Asp Gly Asn Ala Ser Val Ile Phe Pro Leu Gln Lys Phe 
                165                 170                 175     


Leu Phe Asn Phe Leu Ser Lys Ser Ile Ile Gly Ala Asp Pro Ala Ala 
            180                 185                 190         


Ser Pro Gln Val Ala Lys Ser Gly Tyr Ala Met Leu Asp Arg Trp Leu 
        195                 200                 205             


Ala Leu Gln Leu Leu Pro Thr Ile His Ile Gly Val Leu Gln Pro Leu 
    210                 215                 220                 


Val Glu Ile Phe Leu His Ser Trp Ala Tyr Pro Phe Ala Leu Val Ser 
225                 230                 235                 240 


Gly Asp Tyr Asn Lys Leu Tyr Gln Phe Ile Glu Lys Glu Gly Arg Glu 
                245                 250                 255     


Ala Val Glu Arg Ala Lys Ala Glu Phe Gly Leu Thr His Gln Glu Ala 
            260                 265                 270         


Ile His Asn Leu Leu Phe Ile Leu Gly Phe Asn Ala Phe Gly Gly Phe 
        275                 280                 285             


Ser Ile Phe Leu Pro Thr Leu Leu Ser Asn Ile Leu Ser Asp Thr Thr 
    290                 295                 300                 


Gly Leu Gln Asp Arg Leu Arg Lys Glu Val Arg Ala Lys Gly Gly Pro 
305                 310                 315                 320 


Ala Leu Ser Phe Ala Ser Val Lys Glu Met Glu Leu Val Lys Ser Val 
                325                 330                 335     


Val Tyr Glu Thr Leu Arg Leu Asn Pro Pro Val Pro Phe Gln Tyr Ala 
            340                 345                 350         


Arg Ala Arg Lys Asp Phe Gln Leu Lys Ser His Asp Ser Val Phe Asp 
        355                 360                 365             


Ile Lys Lys Gly Glu Leu Leu Cys Gly Tyr Gln Lys Val Val Met Thr 
    370                 375                 380                 


Asp Pro Lys Val Phe Asp Glu Pro Glu Ser Phe Asn Ser Asp Arg Phe 
385                 390                 395                 400 


Val Gln Asn Ser Glu Leu Leu Asn Tyr Leu Tyr Trp Ser Asn Gly Pro 
                405                 410                 415     


Gln Thr Gly Thr Pro Thr Glu Ser Asn Lys Gln Cys Ala Ala Lys Asp 
            420                 425                 430         


Tyr Val Thr Leu Thr Ala Cys Leu Phe Val Ala Tyr Met Phe Arg Arg 
        435                 440                 445             


Tyr Asn Ser Val Thr Gly Ser Ser Ser Ser Ile Thr Ala Val Glu Lys 
    450                 455                 460                 


Ala Asn 
465     


<210>  13
<211>  1401
<212>  DNA
<213>  Aritficial

<400>  13
gctactcctt cttcctcctc ccctgaactc ccgctgaaac cgatcccggg cagctacggg       60

tggcccctcc tcggcccgat atcggaccgc ctggactact tctggttcca aggcccggag      120

acgttcttca ggaagaggat cgagaagtac aagagcaccg tgttccgcgc gaacgtgcct      180

ccgtgcttcc ccttcttctc gaacgtgaac cctaacgtcg tggtcgtcct cgattgcgag      240

tccttcgctc acttgttcga catggagatc gtggagaaga gcaacgtcct cgtcggcgac      300

ttcatgccga gcgtgaagta caccgggaac atccgggtct gcgcttacct cgacacttcc      360

gagcctcaac acgctcaggt gaagaacttt gcgatggaca tactgaagag gagctccaaa      420

gtgtgggaga gcgaagtgat ctcgaacttg gacaccatgt gggacaccat cgagtccagc      480

ctcgccaagg acggcaacgc cagcgtcatc ttccctctcc aaaagttcct cttcaacttc      540

ctctccaagt ccatcatcgg cgctgacccg gccgcctcgc cgcaggtggc caagtccggc      600

tacgccatgc ttgaccggtg gctcgctctc cagctcctcc ccaccatcca cattggcgta      660

ctgcagcctc tagtggagat ttttctgcat tcttgggcat acccttttgc gctggtgagc      720

ggggactaca acaagctcta ccagttcatc gagaaggaag gccgagaagc ggtcgaaagg      780

gcgaaggccg agttcggatt gacacaccag gaggccatcc acaacttgct gttcatcctc      840

ggcttcaacg cgttcggcgg cttctcgatc ttcctcccca cgttgctgag caacatactt      900

agcgacacaa ccggactgca ggaccggctg aggaaggagg tccgggcaaa gggagggccg      960

gcgttgagct tcgcctcggt gaaggagatg gaactcgtga agtcggtcgt gtacgagacg     1020

ctgcggctca acccgcccgt cccgttccaa tacgctcgag cccggaagga cttccagctc     1080

aagtcccacg actctgtctt tgatatcaag aaaggcgagc tgctatgcgg gtatcagaag     1140

gtggtgatga cagacccgaa agtgttcgac gaaccggaga gcttcaactc ggaccggttc     1200

gtccaaaaca gcgagctact gaattacctg tactggtcca acgggccgca gaccggaacg     1260

ccgaccgagt cgaacaagca gtgcgcggct aaggactacg tcaccctcac cgcttgtctc     1320

ttcgttgcct acatgtttcg acggtacaat tccgtcacag gaagctcgag ctcgatcaca     1380

gccgttgaaa aggccaactg a                                               1401


<210>  14
<211>  468
<212>  PRT
<213>  Artificial

<220>
<223>  Variant of WT

<400>  14

Ala Thr Pro Ser Ser Ser Ser Pro Glu Leu Pro Leu Lys Pro Ile Pro 
1               5                   10                  15      


Gly Ser Tyr Gly Trp Pro Leu Leu Gly Pro Ile Ser Asp Arg Leu Asp 
            20                  25                  30          


Tyr Phe Trp Phe Gln Gly Pro Glu Thr Phe Phe Arg Lys Arg Ile Glu 
        35                  40                  45              


Lys Tyr Lys Ser Thr Val Phe Arg Ala Asn Val Pro Pro Cys Phe Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Asn Pro Asn Val Val Val Val Leu Asp Cys Glu 
65                  70                  75                  80  


Ser Phe Ala His Leu Phe Asp Met Glu Ile Val Glu Lys Ser Asn Val 
                85                  90                  95      


Leu Val Gly Asp Phe Met Pro Ser Val Lys Tyr Thr Gly Asn Ile Arg 
            100                 105                 110         


Val Cys Ala Tyr Leu Asp Thr Ser Glu Pro Gln His Ala Gln Val Lys 
        115                 120                 125             


Asn Phe Ala Met Asp Ile Leu Lys Arg Ser Ser Lys Val Trp Glu Ser 
    130                 135                 140                 


Glu Val Ile Ser Asn Leu Asp Thr Met Trp Asp Thr Ile Glu Ser Ser 
145                 150                 155                 160 


Leu Ala Lys Asp Gly Asn Ala Ser Val Ile Phe Pro Leu Gln Lys Phe 
                165                 170                 175     


Leu Phe Asn Phe Leu Ser Lys Ser Ile Ile Gly Ala Asp Pro Ala Ala 
            180                 185                 190         


Ser Pro Gln Val Ala Lys Ser Gly Tyr Ala Met Leu Asp Arg Trp Leu 
        195                 200                 205             


Ala Leu Gln Leu Leu Pro Thr Ile His Ile Gly Val Leu Gln Pro Leu 
    210                 215                 220                 


Val Glu Ile Phe Leu His Ser Trp Ala Tyr Pro Phe Ala Leu Val Ser 
225                 230                 235                 240 


Gly Asp Tyr Asn Lys Leu Tyr Gln Phe Ile Glu Lys Glu Gly Arg Glu 
                245                 250                 255     


Ala Val Glu Arg Ala Lys Ala Glu Phe Gly Leu Thr His Gln Glu Ala 
            260                 265                 270         


Ile His Asn Leu Leu Phe Ile Leu Gly Phe Asn Ala Phe Gly Gly Phe 
        275                 280                 285             


Ser Ile Phe Leu Pro Thr Leu Leu Ser Asn Ile Leu Ser Asp Thr Thr 
    290                 295                 300                 


Gly Leu Gln Asp Arg Leu Arg Lys Glu Val Arg Ala Lys Gly Gly Pro 
305                 310                 315                 320 


Ala Leu Ser Phe Ala Ser Val Lys Glu Met Glu Leu Val Lys Ser Val 
                325                 330                 335     


Val Tyr Glu Thr Leu Arg Leu Asn Pro Pro Val Pro Phe Gln Tyr Ala 
            340                 345                 350         


Arg Ala Arg Lys Asp Phe Gln Leu Lys Ser His Asp Ser Val Phe Asp 
        355                 360                 365             


Ile Lys Lys Gly Glu Leu Leu Cys Gly Tyr Gln Pro Leu Val Met Arg 
    370                 375                 380                 


Asp Ser Lys Val Phe Asp Asp Ala Glu Ser Phe Lys Ala Glu Arg Phe 
385                 390                 395                 400 


Met Gly Glu Lys Gly Ser Glu Leu Leu Ser Tyr Leu Tyr Trp Ser Asn 
                405                 410                 415     


Gly Pro Gln Thr Gly Thr Pro Thr Glu Ser Asn Lys Gln Cys Ala Ala 
            420                 425                 430         


Lys Asp Tyr Val Thr Leu Thr Ala Cys Leu Phe Val Ala Tyr Met Phe 
        435                 440                 445             


Arg Arg Tyr Asn Ser Val Thr Gly Ser Ser Ser Ser Ile Thr Ala Val 
    450                 455                 460                 


Glu Lys Ala Asn 
465             


<210>  15
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  Variant of WT

<400>  15
gctactcctt cttcctcctc ccctgaactc ccgctgaaac cgatcccggg cagctacggg       60

tggcccctcc tcggcccgat atcggaccgc ctggactact tctggttcca aggcccggag      120

acgttcttca ggaagaggat cgagaagtac aagagcaccg tgttccgcgc gaacgtgcct      180

ccgtgcttcc ccttcttctc gaacgtgaac cctaacgtcg tggtcgtcct cgattgcgag      240

tccttcgctc acttgttcga catggagatc gtggagaaga gcaacgtcct cgtcggcgac      300

ttcatgccga gcgtgaagta caccgggaac atccgggtct gcgcttacct cgacacttcc      360

gagcctcaac acgctcaggt gaagaacttt gcgatggaca tactgaagag gagctccaaa      420

gtgtgggaga gcgaagtgat ctcgaacttg gacaccatgt gggacaccat cgagtccagc      480

ctcgccaagg acggcaacgc cagcgtcatc ttccctctcc aaaagttcct cttcaacttc      540

ctctccaagt ccatcatcgg cgctgacccg gccgcctcgc cgcaggtggc caagtccggc      600

tacgccatgc ttgaccggtg gctcgctctc cagctcctcc ccaccatcca cattggcgta      660

ctgcagcctc tagtggagat ttttctgcat tcttgggcat acccttttgc gctggtgagc      720

ggggactaca acaagctcta ccagttcatc gagaaggaag gccgagaagc ggtcgaaagg      780

gcgaaggccg agttcggatt gacacaccag gaggccatcc acaacttgct gttcatcctc      840

ggcttcaacg cgttcggcgg cttctcgatc ttcctcccca cgttgctgag caacatactt      900

agcgacacaa ccggactgca ggaccggctg aggaaggagg tccgggcaaa gggagggccg      960

gcgttgagct tcgcctcggt gaaggagatg gaactcgtga agtcggtcgt gtacgagacg     1020

ctgcggctca acccgcccgt cccgttccaa tacgctcgag cccggaagga cttccagctc     1080

aagtcccacg actctgtctt tgatatcaag aaaggcgagc tgctatgcgg gtatcagcct     1140

ttggtcatga gggattcgaa ggtgtttgac gatgctgaga gttttaaggc tgagaggttt     1200

atgggcgaaa agggcagcga gctactgagt tacctgtact ggtccaacgg gccgcagacc     1260

ggaacgccga ccgagtcgaa caagcagtgc gcggctaagg actacgtcac cctcaccgct     1320

tgtctcttcg ttgcctacat gtttcgacgg tacaattccg tcacaggaag ctcgagctcg     1380

atcacagccg ttgaaaaggc caactga                                         1407


<210>  16
<211>  468
<212>  PRT
<213>  Artificial

<220>
<223>  modified sequence

<400>  16

Ala Thr Pro Ser Ser Ser Ser Pro Glu Leu Pro Leu Lys Pro Ile Pro 
1               5                   10                  15      


Gly Ser Tyr Gly Trp Pro Leu Leu Gly Pro Ile Leu Asp Arg Leu Asp 
            20                  25                  30          


Tyr Phe Trp Phe Gln Gly Pro Glu Thr Phe Phe Arg Lys Arg Ile Glu 
        35                  40                  45              


Lys Tyr Lys Ser Thr Val Phe Arg Ala Asn Val Pro Pro Cys Phe Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Asn Pro Asn Val Val Val Val Leu Asp Cys Glu 
65                  70                  75                  80  


Ser Phe Ala His Leu Phe Asp Met Glu Ile Val Glu Lys Ser Asn Val 
                85                  90                  95      


Leu Val Gly Asp Phe Met Pro Ser Val Lys Tyr Thr Gly Asn Ile Arg 
            100                 105                 110         


Val Cys Ala Tyr Leu Asp Thr Ser Glu Pro Gln His Ala Gln Val Lys 
        115                 120                 125             


Asn Phe Ala Met Asp Ile Leu Lys Arg Ser Ser Lys Val Trp Glu Ser 
    130                 135                 140                 


Glu Val Ile Ser Asn Leu Asp Thr Met Trp Asp Thr Ile Glu Ser Ser 
145                 150                 155                 160 


Leu Ala Lys Asp Gly Asn Ala Ser Val Ile Phe Pro Leu Gln Lys Phe 
                165                 170                 175     


Leu Phe Asn Phe Leu Ser Lys Ser Ile Ile Gly Ala Asp Pro Ala Ala 
            180                 185                 190         


Ser Pro Gln Val Ala Lys Ser Gly Tyr Ala Met Leu Asp Arg Trp Leu 
        195                 200                 205             


Ala Leu Gln Leu Leu Pro Thr Ile His Ile Gly Val Leu Gln Pro Leu 
    210                 215                 220                 


Val Glu Ile Phe Leu His Ser Trp Ala Tyr Pro Phe Ala Leu Val Ser 
225                 230                 235                 240 


Gly Asp Tyr Asn Lys Leu Tyr Gln Phe Ile Glu Lys Glu Gly Arg Glu 
                245                 250                 255     


Ala Val Glu Arg Ala Lys Ala Glu Phe Gly Leu Thr His Gln Glu Ala 
            260                 265                 270         


Ile His Asn Leu Leu Phe Ile Leu Gly Phe Asn Ala Phe Gly Gly Phe 
        275                 280                 285             


Ser Ile Phe Leu Pro Thr Leu Leu Ser Asn Ile Leu Ser Asp Thr Thr 
    290                 295                 300                 


Gly Leu Gln Asp Arg Leu Arg Lys Glu Val Arg Ala Lys Gly Gly Pro 
305                 310                 315                 320 


Ala Leu Ser Phe Ala Ser Val Lys Glu Met Glu Leu Val Lys Ser Val 
                325                 330                 335     


Val Tyr Glu Thr Leu Arg Leu Asn Pro Pro Val Pro Leu Gln Phe Ala 
            340                 345                 350         


Arg Ala Arg Lys Asp Phe Gln Leu Ser Ser Tyr Asp Ser Val Tyr Asp 
        355                 360                 365             


Ile Lys Lys Gly Glu Leu Leu Cys Gly Tyr Gln Pro Leu Val Met Arg 
    370                 375                 380                 


Asp Ser Lys Val Phe Asp Asp Ala Glu Ser Phe Lys Ala Glu Arg Phe 
385                 390                 395                 400 


Met Gly Glu Lys Gly Ser Glu Leu Leu Ser Tyr Leu Tyr Trp Ser Asn 
                405                 410                 415     


Gly Pro Gln Thr Gly Thr Pro Thr Glu Ser Asn Lys Gln Cys Ala Ala 
            420                 425                 430         


Lys Asp Tyr Val Thr Leu Thr Ala Cys Leu Phe Val Ala Tyr Met Phe 
        435                 440                 445             


Arg Arg Tyr Asn Ser Val Thr Gly Ser Ser Ser Ser Ile Thr Ala Val 
    450                 455                 460                 


Glu Lys Ala Lys 
465             


<210>  17
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  Modified sequence

<400>  17
gctactcctt cttcctcctc ccctgaactc ccgctgaaac cgatcccggg cagctacggg       60

tggcccctcc tcggcccgat attggaccgc ctggactact tctggttcca aggcccggag      120

acgttcttca ggaagaggat cgagaagtac aagagcaccg tgttccgcgc gaacgtgcct      180

ccgtgcttcc ccttcttctc gaacgtgaac cctaacgtcg tggtcgtcct cgattgcgag      240

tccttcgctc acttgttcga catggagatc gtggagaaga gcaacgtcct cgtcggcgac      300

ttcatgccga gcgtgaagta caccgggaac atccgggtct gcgcttacct cgacacttcc      360

gagcctcaac acgctcaggt gaagaacttt gcgatggaca tactgaagag gagctccaaa      420

gtgtgggaga gcgaagtgat ctcgaacttg gacaccatgt gggacaccat cgagtccagc      480

ctcgccaagg acggcaacgc cagcgtcatc ttccctctcc aaaagttcct cttcaacttc      540

ctctccaagt ccatcatcgg cgctgacccg gccgcctcgc cgcaggtggc caagtccggc      600

tacgccatgc ttgaccggtg gctcgctctc cagctcctcc ccaccatcca cattggcgta      660

ctgcagcctc tagtggagat ttttctgcat tcttgggcat acccttttgc gctggtgagc      720

ggggactaca acaagctcta ccagttcatc gagaaggaag gccgagaagc ggtcgaaagg      780

gcgaaggccg agttcggatt gacacaccag gaggccatcc acaacttgct gttcatcctc      840

ggcttcaacg cgttcggcgg cttctcgatc ttcctcccca cgttgctgag caacatactt      900

agcgacacaa ccggactgca ggaccggctg aggaaggagg tccgggcaaa gggagggccg      960

gcgttgagct tcgcctcggt gaaggagatg gaactcgtga agtcggtcgt gtacgagacg     1020

ctgcggctca acccgcccgt cccgctccag tttgctcgag cccggaagga cttccagctc     1080

agctcgtacg actcggtgta cgatatcaag aaaggcgagc tgctatgcgg gtatcagcct     1140

ttggtcatga gggattcgaa ggtgtttgac gatgctgaga gttttaaggc tgagaggttt     1200

atgggcgaaa agggcagcga gctactgagt tacctgtact ggtccaacgg gccgcagacc     1260

ggaacgccga ccgagtcgaa caagcagtgc gcggctaagg actacgtcac cctcaccgct     1320

tgtctcttcg ttgcctacat gtttcgacgg tacaattccg tcacaggaag ctcgagctcg     1380

atcacagccg ttgaaaaggc caagtga                                         1407


