                         SEQUENCE LISTING

<110>  Washington State University
 
<120>  Allelic Exchange Mutagenesis In MAP

<130>  67901-114

<160>  49    

<170>  PatentIn version 3.3

<210>  1
<211>  2292
<212>  DNA
<213>  Mycobacterium avium

<400>  1
tcagaacgtg ctggtgggtc gcaccttgtt ggccatgtcc accagcgcgt agcggtgccg     60

ctgggtgggg gcgacgcggg ccaggttgcg cagcgccgcc tcgacgccca gccgcagccc    120

gtgctcggtg aacgggaagc ccaggatgtg gttggtgctg gccttgttgt cctccagcca    180

gtccatcgcg cagccgagca ccagcgcgcg gatctgcaac acccgcggct cggtcggcgg    240

cagcgcctcc acccgccggg ccgcgtcccg gatttcctct tcggtgatct cgctcttgga    300

ccgcccggac aacagcgtca ccgcgctggt cagccgcgcg gtggtgaagt gccgcgaggt    360

ggccggcacc tcgtcgaggg tgcgcaccgc ggcggcccga tcaccctcgg cggacagggt    420

tctggccaat ccgaaggccg ccgagatcac gccgtcgttg gtcttccaca ccgtctcgta    480

gaaccggtgc tcgtcgacgt cgccggccag ctcggcggtc gcggccaacg ccaacttggg    540

cgccagctcg cccgggaagg tgtccagcac ctcggtgaaa tgcgttgtgg ccgaatcgta    600

gtcgccggtc agcagctcgg ccaccgcctt gtaccagacc agccgccact gccagccgac    660

ccgctcggcc aggtcgtcga gcttgcgggt ggccttggcc acgtcgccga ggtccagcag    720

cgcgcgcacc tccatcagcg gcagctcgat cgactcggac agctcgaccc cgtcggcgtc    780

cagcgtcccg tgccgggccg cgcgcagcga gtccagcgtc tgcaccggct gcgacaacac    840

cgtcgcctgc agcaccgggg cggcgacgtc ggccggatcg accagcggca cctgcagcgc    900

ggtcacgatc tcgcgggcgg tcagcttctc cgaatgcacc tggccgtcca ggtacacgtc    960

ggtgtgcgcg accagcaggt cgaccccgaa cgtcgagcgg ctgggcgaga agatggtcga   1020

caggccgggc cgcggcaccc cggtgtcgtg cgcgaccacc tcgcgcagca cccccatcag   1080

ctgggccgac atctcctcgg tgctggagaa ccggcgccgc gggtcggggt cggtggcgcg   1140

gcgcagcaac cggcggaagg agtcgtaggt gcccagcacc gggtcgttgt cggggatgcc   1200

gtcgacgtag cggccgttgc gggtgggcag gttcagcgtg agcgcggcca gcgtgcgccc   1260

caccgtgtag atgtcggtgg ccaccgtcgg gccggtccgc acgatctccg gcgcctggaa   1320

acccggtgtg ccgtaaaggt atccgaacga gttgatccgc gacaccgcgc ccaggtcgat   1380

cagcttgagc tgctcctcgg tgagcatgat gttctccggc ttgaggtcgt tgtagaccag   1440

gccgatcgag tgcaggtaac ccagcgccgg cagtatctcc agcacgtagg cgatggcctc   1500

ggagacgggc agcttctcgc ccttgccgtg ccgcagcggc tgcccgccga cgtactccat   1560

gacgatgtag ccgaccggat tcccgtgccg gtccacatgc tcgacgaagt tgaagatctg   1620

cacgatctgc gggtgcacca cctcggcgag gaactgccgt tcggccatcg cgatggcctg   1680

cgcctcggcg tcaccggagt gcaccaggcc cttgagcacc accggccggt cgttgacgtt   1740

gtggtccacc gccaggtaga cccagcccag cccgccgtgc gcgatgcagc ccttgacctc   1800

gtactggttg gcgacgatgt cgcccggatt cagttgcggc agaaacgaat acgcgctgcc   1860

gcagtgcggg caccagccct cggaggtgcc cttgctcttc ttggtggacc gccccaccgg   1920

tttgccgcag ttccagcaga agcgcttgga ctccggcacc accgggttgg tcatcagcgc   1980

ctcgcgcggg tcgatgtcgc ggccgcgcgg aatctcgacc agcccaccgc cgagctgacg   2040

gaccggcggc agcgcctgcg tcgccaccgt catgcggtcg gcgctgtcgg tgtccagggc   2100

acccagcgag atgtgcggga agtcgtcgtc gtcatcgtcg aagtcgggcc ggaacagcgc   2160

ctgggtggcc tgcagccgcc cggttgccgc gccggcctgg gcgtcgtcgc ccacctcggc   2220

cggctgggtg cccgggccca tctgctcggc ccccggttcc ggctgctcgc tcttgttgtc   2280

cggctcggcc at                                                       2292


<210>  2
<211>  763
<212>  PRT
<213>  Mycobacterium avium

<400>  2

Met Ala Glu Pro Asp Asn Lys Ser Glu Gln Pro Glu Pro Gly Ala Glu 
1               5                   10                  15      


Gln Met Gly Pro Gly Thr Gln Pro Ala Glu Val Gly Asp Asp Ala Gln 
            20                  25                  30          


Ala Gly Ala Ala Thr Gly Arg Leu Gln Ala Thr Gln Ala Leu Phe Arg 
        35                  40                  45              


Pro Asp Phe Asp Asp Asp Asp Asp Asp Phe Pro His Ile Ser Leu Gly 
    50                  55                  60                  


Ala Leu Asp Thr Asp Ser Ala Asp Arg Met Thr Val Ala Thr Gln Ala 
65                  70                  75                  80  


Leu Pro Pro Val Arg Gln Leu Gly Gly Gly Leu Val Glu Ile Pro Arg 
                85                  90                  95      


Gly Arg Asp Ile Asp Pro Arg Glu Ala Leu Met Thr Asn Pro Val Val 
            100                 105                 110         


Pro Glu Ser Lys Arg Phe Cys Trp Asn Cys Gly Lys Pro Val Gly Arg 
        115                 120                 125             


Ser Thr Lys Lys Ser Lys Gly Thr Ser Glu Gly Trp Cys Pro His Cys 
    130                 135                 140                 


Gly Ser Ala Tyr Ser Phe Leu Pro Gln Leu Asn Pro Gly Asp Ile Val 
145                 150                 155                 160 


Ala Asn Gln Tyr Glu Val Lys Gly Cys Ile Ala His Gly Gly Leu Gly 
                165                 170                 175     


Trp Val Tyr Leu Ala Val Asp His Asn Val Asn Asp Arg Pro Val Val 
            180                 185                 190         


Leu Lys Gly Leu Val His Ser Gly Asp Ala Glu Ala Gln Ala Ile Ala 
        195                 200                 205             


Met Ala Glu Arg Gln Phe Leu Ala Glu Val Val His Pro Gln Ile Val 
    210                 215                 220                 


Gln Ile Phe Asn Phe Val Glu His Val Asp Arg His Gly Asn Pro Val 
225                 230                 235                 240 


Gly Tyr Ile Val Met Glu Tyr Val Gly Gly Gln Pro Leu Arg His Gly 
                245                 250                 255     


Lys Gly Glu Lys Leu Pro Val Ser Glu Ala Ile Ala Tyr Val Leu Glu 
            260                 265                 270         


Ile Leu Pro Ala Leu Gly Tyr Leu His Ser Ile Gly Leu Val Tyr Asn 
        275                 280                 285             


Asp Leu Lys Pro Glu Asn Ile Met Leu Thr Glu Glu Gln Leu Lys Leu 
    290                 295                 300                 


Ile Asp Leu Gly Ala Val Ser Arg Ile Asn Ser Phe Gly Tyr Leu Tyr 
305                 310                 315                 320 


Gly Thr Pro Gly Phe Gln Ala Pro Glu Ile Val Arg Thr Gly Pro Thr 
                325                 330                 335     


Val Ala Thr Asp Ile Tyr Thr Val Gly Arg Thr Leu Ala Ala Leu Thr 
            340                 345                 350         


Leu Asn Leu Pro Thr Arg Asn Gly Arg Tyr Val Asp Gly Ile Pro Asp 
        355                 360                 365             


Asn Asp Pro Val Leu Gly Thr Tyr Asp Ser Phe Arg Arg Leu Leu Arg 
    370                 375                 380                 


Arg Ala Thr Asp Pro Asp Pro Arg Arg Arg Phe Ser Ser Thr Glu Glu 
385                 390                 395                 400 


Met Ser Ala Gln Leu Met Gly Val Leu Arg Glu Val Val Ala His Asp 
                405                 410                 415     


Thr Gly Val Pro Arg Pro Gly Leu Ser Thr Ile Phe Ser Pro Ser Arg 
            420                 425                 430         


Ser Thr Phe Gly Val Asp Leu Leu Val Ala His Thr Asp Val Tyr Leu 
        435                 440                 445             


Asp Gly Gln Val His Ser Glu Lys Leu Thr Ala Arg Glu Ile Val Thr 
    450                 455                 460                 


Ala Leu Gln Val Pro Leu Val Asp Pro Ala Asp Val Ala Ala Pro Val 
465                 470                 475                 480 


Leu Gln Ala Thr Val Leu Ser Gln Pro Val Gln Thr Leu Asp Ser Leu 
                485                 490                 495     


Arg Ala Ala Arg His Gly Thr Leu Asp Ala Asp Gly Val Glu Leu Ser 
            500                 505                 510         


Glu Ser Ile Glu Leu Pro Leu Met Glu Val Arg Ala Leu Leu Asp Leu 
        515                 520                 525             


Gly Asp Val Ala Lys Ala Thr Arg Lys Leu Asp Asp Leu Ala Glu Arg 
    530                 535                 540                 


Val Gly Trp Gln Trp Arg Leu Val Trp Tyr Lys Ala Val Ala Glu Leu 
545                 550                 555                 560 


Leu Thr Gly Asp Tyr Asp Ser Ala Thr Thr His Phe Thr Glu Val Leu 
                565                 570                 575     


Asp Thr Phe Pro Gly Glu Leu Ala Pro Lys Leu Ala Leu Ala Ala Thr 
            580                 585                 590         


Ala Glu Leu Ala Gly Asp Val Asp Glu His Arg Phe Tyr Glu Thr Val 
        595                 600                 605             


Trp Lys Thr Asn Asp Gly Val Ile Ser Ala Ala Phe Gly Leu Ala Arg 
    610                 615                 620                 


Thr Leu Ser Ala Glu Gly Asp Arg Ala Ala Ala Val Arg Thr Leu Asp 
625                 630                 635                 640 


Glu Val Pro Ala Thr Ser Arg His Phe Thr Thr Ala Arg Leu Thr Ser 
                645                 650                 655     


Ala Val Thr Leu Leu Ser Gly Arg Ser Lys Ser Glu Ile Thr Glu Glu 
            660                 665                 670         


Glu Ile Arg Asp Ala Ala Arg Arg Val Glu Ala Leu Pro Pro Thr Glu 
        675                 680                 685             


Pro Arg Val Leu Gln Ile Arg Ala Leu Val Leu Gly Cys Ala Met Asp 
    690                 695                 700                 


Trp Leu Glu Asp Asn Lys Ala Ser Thr Asn His Ile Leu Gly Phe Pro 
705                 710                 715                 720 


Phe Thr Glu His Gly Leu Arg Leu Gly Val Glu Ala Ala Leu Arg Asn 
                725                 730                 735     


Leu Ala Arg Val Ala Pro Thr Gln Arg His Arg Tyr Ala Leu Val Asp 
            740                 745                 750         


Met Ala Asn Lys Val Arg Pro Thr Ser Thr Phe 
        755                 760             


<210>  3
<211>  309
<212>  PRT
<213>  Mycobacterium avium

<400>  3

Met Leu Val Ala Ala Gly Cys Gly His Thr Glu Ser Leu Arg Val Ala 
1               5                   10                  15      


Ser Val Pro Thr Leu Pro Pro Pro Thr Pro Val Gly Met Glu Gln Leu 
            20                  25                  30          


Pro Pro Gln Pro Pro Leu Pro Pro Asp Gly Pro Asp Gln Asn Cys Asp 
        35                  40                  45              


Leu Thr Ala Ser Leu Arg Pro Phe Pro Thr Lys Ala Glu Ala Asp Ala 
    50                  55                  60                  


Ala Val Ala Asp Ile Arg Ala Arg Gly Arg Leu Ile Val Gly Leu Asp 
65                  70                  75                  80  


Ile Gly Ser Asn Leu Phe Ser Phe Arg Asp Pro Ile Thr Gly Glu Ile 
                85                  90                  95      


Thr Gly Phe Asp Val Asp Ile Ala Gly Glu Ile Ala Arg Asp Ile Phe 
            100                 105                 110         


Gly Ala Pro Ser His Val Glu Tyr Arg Ile Leu Ser Ser Asp Glu Arg 
        115                 120                 125             


Val Thr Ala Leu Gln Arg Gly Glu Val Asp Val Val Val Lys Thr Met 
    130                 135                 140                 


Thr Ile Thr Cys Asp Arg Arg Lys Gln Val Asn Phe Ser Thr Val Tyr 
145                 150                 155                 160 


Leu Asp Ala Asn Gln Arg Ile Leu Ala Pro Arg Asp Ser Pro Ile Thr 
                165                 170                 175     


Lys Val Ser Asp Leu Ser Gly Lys Arg Val Cys Val Ala Lys Gly Thr 
            180                 185                 190         


Thr Ser Leu His Arg Ile Arg Gln Ile Asp Pro Pro Pro Ile Val Val 
        195                 200                 205             


Ser Val Val Asn Trp Ala Asp Cys Leu Val Ala Met Gln Gln Arg Glu 
    210                 215                 220                 


Ile Asp Ala Val Ser Thr Asp Asp Ser Ile Leu Ala Gly Leu Val Glu 
225                 230                 235                 240 


Glu Asp Pro Tyr Leu His Ile Val Gly Pro Asn Met Ala Thr Gln Pro 
                245                 250                 255     


Tyr Gly Ile Gly Ile Asn Leu Asn Asn Thr Gly Leu Val Arg Phe Val 
            260                 265                 270         


Asn Gly Thr Leu Glu Arg Ile Arg Arg Asp Gly Thr Trp Asn Thr Leu 
        275                 280                 285             


Tyr Arg Lys Trp Leu Thr Val Leu Gly Pro Ala Pro Ala Pro Pro Thr 
    290                 295                 300                 


Pro Arg Tyr Leu Asp 
305                 


<210>  4
<211>  2367
<212>  DNA
<213>  Mycobacterium avium

<400>  4
gtggcggagg aaaacagcgc ggcgcaagcg cttgacgcgc cggcggagtc gccgcccaac     60

ccggtgatcg agactcccga gccgccgacc gaatcgctca agacgtccag cagcgcgtcg    120

cgccgggtcc gggcccggct ggcccggcgg atgaccgccc agcgcagcac gctcaacccg    180

gtgctggagc cgctggtggc gatgcaccgc gagatctacc ccaaggccaa cgtgcagctg    240

ctgcagcgcg cattcgaggt cgccgaccag cggcacgcca gccagttgcg ccactccggc    300

gacccctaca tcacccatcc gctggccgtc gccaccatcc tggccgaatt gggcatggac    360

accaccactt tggtggccgc gctgttgcac gacaccgtcg aggacaccgg ctacaccctg    420

gcccagctgt ccgaggaatt cggcgaagag gtcggtcatc tggtcgacgg ggtgaccaag    480

ctggaccggg tggtgctggg cagcgccgcc gagggcgaga ccatccgcaa gatgatcacc    540

gcgatggccc gcgacccgcg ggtgctggtg atcaaggtcg ccgaccggct gcacaacatg    600

cgcaccatgc ggttcctgcc gccggagaag caggcccgca aggcccgcga gacgctggaa    660

gtcattgcgc ccctcgccca tcggctgggc atggccagcg tcaagtggga gttggaggac    720

ctgtcgttcg ccatcctgca tcccaagaag tacgacgaga tcgtccggct ggtcgccggc    780

cgggccccgt cgcgggacac ctacctggcc aaggtgcggg ccgagatcat caacacgctg    840

aacgcgtcga agatcaaggc gacggtggag ggccggccca agcactactg gtcgatctac    900

cagaagatga tcgtcaaggg ccgcgacttc gacgacatcc acgacctggt cggcatccgc    960

atcctgtgcg acgagatccg ggactgctat gccgctgtgg gcgtggtgca ttcgctgtgg   1020

cagccgatgg ccgggcggtt caaggactac atcgcccagc cgcgctacgg cgtctaccag   1080

tcgctgcaca ccaccgtcgt cgggccggag ggcaagccgc tggaggtgca gatccgcacc   1140

cgcgacatgc accgcaccgc cgagtacggc atcgccgcgc actggcgcta caaggaagcc   1200

aagggccgca acggcgttcc gcacccgcac gccgccgccg agatcgacga catggcctgg   1260

atgcgccagc tgctcgactg gcagcgggaa gccgccgacc cgggcgaatt cctcgagtcg   1320

ctgcgctatg accttgcggt acaagagatc ttcgtgttca cccccaaggg cgacgtgatc   1380

accctgccca ccgggtcgac gccgatcgac ttcgcctatg ccgtgcacac cgaggtcggg   1440

caccgctgca tcggcgcccg ggtcaacggc cggctggtgg cgctggaacg caagctggaa   1500

aacggggaag tcgtcgaggt tttcacctcc aaggcggcca acgcgggccc gtcgcgggac   1560

tggcagcagt tcgtggtgtc gccgcgggcc aaggccaaga tccggcagtg gttcgccaag   1620

gagcggcgcg aggaggccct ggaggccggc aaggacgcga tggcccgcga ggtgcgccgc   1680

ggcggacttc cgttgcagcg cttggtcaat gccgaatcca tgagcgcggt ggcccgcgaa   1740

ctgcactacg ccgacgtgtc ggccctctac accgcgatcg gtgaggggca tgtgtcggcc   1800

cggcacgtgg tgcagcggct gctggccgag ctcggcggca tcgaccagac cgaggaggac   1860

ctcgccgagc ggtccacccc gaccaccatg ctgcgccgcc cgcgcagcag cgacgacgtc   1920

ggcgtgtcgg tgcccggcgc cccgggcgtg ctgaccaagc tggccaaatg ctgcacgccg   1980

gtgcctgggg accagatcat gggattcgtc acccgcggcg gcggggtgag cgtgcaccgc   2040

accgactgca ccaacgccgc ctcgctgcag cagcagtccg agcgcatcat cgaggtgcac   2100

tgggcgccgt cgccgtcgtc ggtgttcctg gtggccattc aggtcgaggc gctcgaccgg   2160

caccggctgt tgtccgacgt cacccgggtg ctggccgacg agaaggtcaa catcctgtcc   2220

gcgtcggtca ccacctccgg tgaccgggtt gccatcagcc gcttcacctt tgagatgggc   2280

gaccccaagc acctcggcca cctgctcaac gtggtgcgca acgtcgaagg cgtctacgac   2340

gtctaccggg tgacctccgc cgcctga                                       2367


<210>  5
<211>  788
<212>  PRT
<213>  Mycobacterium avium

<400>  5

Met Ala Glu Glu Asn Ser Ala Ala Gln Ala Leu Asp Ala Pro Ala Glu 
1               5                   10                  15      


Ser Pro Pro Asn Pro Val Ile Glu Thr Pro Glu Pro Pro Thr Glu Ser 
            20                  25                  30          


Leu Lys Thr Ser Ser Ser Ala Ser Arg Arg Val Arg Ala Arg Leu Ala 
        35                  40                  45              


Arg Arg Met Thr Ala Gln Arg Ser Thr Leu Asn Pro Val Leu Glu Pro 
    50                  55                  60                  


Leu Val Ala Met His Arg Glu Ile Tyr Pro Lys Ala Asn Val Gln Leu 
65                  70                  75                  80  


Leu Gln Arg Ala Phe Glu Val Ala Asp Gln Arg His Ala Ser Gln Leu 
                85                  90                  95      


Arg His Ser Gly Asp Pro Tyr Ile Thr His Pro Leu Ala Val Ala Thr 
            100                 105                 110         


Ile Leu Ala Glu Leu Gly Met Asp Thr Thr Thr Leu Val Ala Ala Leu 
        115                 120                 125             


Leu His Asp Thr Val Glu Asp Thr Gly Tyr Thr Leu Ala Gln Leu Ser 
    130                 135                 140                 


Glu Glu Phe Gly Glu Glu Val Gly His Leu Val Asp Gly Val Thr Lys 
145                 150                 155                 160 


Leu Asp Arg Val Val Leu Gly Ser Ala Ala Glu Gly Glu Thr Ile Arg 
                165                 170                 175     


Lys Met Ile Thr Ala Met Ala Arg Asp Pro Arg Val Leu Val Ile Lys 
            180                 185                 190         


Val Ala Asp Arg Leu His Asn Met Arg Thr Met Arg Phe Leu Pro Pro 
        195                 200                 205             


Glu Lys Gln Ala Arg Lys Ala Arg Glu Thr Leu Glu Val Ile Ala Pro 
    210                 215                 220                 


Leu Ala His Arg Leu Gly Met Ala Ser Val Lys Trp Glu Leu Glu Asp 
225                 230                 235                 240 


Leu Ser Phe Ala Ile Leu His Pro Lys Lys Tyr Asp Glu Ile Val Arg 
                245                 250                 255     


Leu Val Ala Gly Arg Ala Pro Ser Arg Asp Thr Tyr Leu Ala Lys Val 
            260                 265                 270         


Arg Ala Glu Ile Ile Asn Thr Leu Asn Ala Ser Lys Ile Lys Ala Thr 
        275                 280                 285             


Val Glu Gly Arg Pro Lys His Tyr Trp Ser Ile Tyr Gln Lys Met Ile 
    290                 295                 300                 


Val Lys Gly Arg Asp Phe Asp Asp Ile His Asp Leu Val Gly Ile Arg 
305                 310                 315                 320 


Ile Leu Cys Asp Glu Ile Arg Asp Cys Tyr Ala Ala Val Gly Val Val 
                325                 330                 335     


His Ser Leu Trp Gln Pro Met Ala Gly Arg Phe Lys Asp Tyr Ile Ala 
            340                 345                 350         


Gln Pro Arg Tyr Gly Val Tyr Gln Ser Leu His Thr Thr Val Val Gly 
        355                 360                 365             


Pro Glu Gly Lys Pro Leu Glu Val Gln Ile Arg Thr Arg Asp Met His 
    370                 375                 380                 


Arg Thr Ala Glu Tyr Gly Ile Ala Ala His Trp Arg Tyr Lys Glu Ala 
385                 390                 395                 400 


Lys Gly Arg Asn Gly Val Pro His Pro His Ala Ala Ala Glu Ile Asp 
                405                 410                 415     


Asp Met Ala Trp Met Arg Gln Leu Leu Asp Trp Gln Arg Glu Ala Ala 
            420                 425                 430         


Asp Pro Gly Glu Phe Leu Glu Ser Leu Arg Tyr Asp Leu Ala Val Gln 
        435                 440                 445             


Glu Ile Phe Val Phe Thr Pro Lys Gly Asp Val Ile Thr Leu Pro Thr 
    450                 455                 460                 


Gly Ser Thr Pro Ile Asp Phe Ala Tyr Ala Val His Thr Glu Val Gly 
465                 470                 475                 480 


His Arg Cys Ile Gly Ala Arg Val Asn Gly Arg Leu Val Ala Leu Glu 
                485                 490                 495     


Arg Lys Leu Glu Asn Gly Glu Val Val Glu Val Phe Thr Ser Lys Ala 
            500                 505                 510         


Ala Asn Ala Gly Pro Ser Arg Asp Trp Gln Gln Phe Val Val Ser Pro 
        515                 520                 525             


Arg Ala Lys Ala Lys Ile Arg Gln Trp Phe Ala Lys Glu Arg Arg Glu 
    530                 535                 540                 


Glu Ala Leu Glu Ala Gly Lys Asp Ala Met Ala Arg Glu Val Arg Arg 
545                 550                 555                 560 


Gly Gly Leu Pro Leu Gln Arg Leu Val Asn Ala Glu Ser Met Ser Ala 
                565                 570                 575     


Val Ala Arg Glu Leu His Tyr Ala Asp Val Ser Ala Leu Tyr Thr Ala 
            580                 585                 590         


Ile Gly Glu Gly His Val Ser Ala Arg His Val Val Gln Arg Leu Leu 
        595                 600                 605             


Ala Glu Leu Gly Gly Ile Asp Gln Thr Glu Glu Asp Leu Ala Glu Arg 
    610                 615                 620                 


Ser Thr Pro Thr Thr Met Leu Arg Arg Pro Arg Ser Ser Asp Asp Val 
625                 630                 635                 640 


Gly Val Ser Val Pro Gly Ala Pro Gly Val Leu Thr Lys Leu Ala Lys 
                645                 650                 655     


Cys Cys Thr Pro Val Pro Gly Asp Gln Ile Met Gly Phe Val Thr Arg 
            660                 665                 670         


Gly Gly Gly Val Ser Val His Arg Thr Asp Cys Thr Asn Ala Ala Ser 
        675                 680                 685             


Leu Gln Gln Gln Ser Glu Arg Ile Ile Glu Val His Trp Ala Pro Ser 
    690                 695                 700                 


Pro Ser Ser Val Phe Leu Val Ala Ile Gln Val Glu Ala Leu Asp Arg 
705                 710                 715                 720 


His Arg Leu Leu Ser Asp Val Thr Arg Val Leu Ala Asp Glu Lys Val 
                725                 730                 735     


Asn Ile Leu Ser Ala Ser Val Thr Thr Ser Gly Asp Arg Val Ala Ile 
            740                 745                 750         


Ser Arg Phe Thr Phe Glu Met Gly Asp Pro Lys His Leu Gly His Leu 
        755                 760                 765             


Leu Asn Val Val Arg Asn Val Glu Gly Val Tyr Asp Val Tyr Arg Val 
    770                 775                 780                 


Thr Ser Ala Ala 
785             


<210>  6
<211>  339
<212>  DNA
<213>  Mycobacterium avium

<400>  6
atggcaaaaa aagtgaccgt caccttggtc gatgatttcg acggtgccgg cgcagccgac     60

gaaacagtgg aattcgggct tgacggggtg acctacgaga ttgacctttc gtccaagaat    120

gccgcgaaac ttcgtaatga tctgaagcaa tgggtggaag ccggccgtcg cgtcggcggc    180

cgccggcgcg ggcgctcggg ctcgggacgc ggccgcggcg ccatcgaccg cgagcagagc    240

gcggcgatcc gcgaatgggc ccgtcgcaac gggcacaacg tgtcgacccg cggccgcatc    300

ccggccgacg tcatcgacgc cttccacgcc gcaacctga                           339


<210>  7
<211>  112
<212>  PRT
<213>  Mycobacterium avium

<400>  7

Met Ala Lys Lys Val Thr Val Thr Leu Val Asp Asp Phe Asp Gly Ala 
1               5                   10                  15      


Gly Ala Ala Asp Glu Thr Val Glu Phe Gly Leu Asp Gly Val Thr Tyr 
            20                  25                  30          


Glu Ile Asp Leu Ser Ser Lys Asn Ala Ala Lys Leu Arg Asn Asp Leu 
        35                  40                  45              


Lys Gln Trp Val Glu Ala Gly Arg Arg Val Gly Gly Arg Arg Arg Gly 
    50                  55                  60                  


Arg Ser Gly Ser Gly Arg Gly Arg Gly Ala Ile Asp Arg Glu Gln Ser 
65                  70                  75                  80  


Ala Ala Ile Arg Glu Trp Ala Arg Arg Asn Gly His Asn Val Ser Thr 
                85                  90                  95      


Arg Gly Arg Ile Pro Ala Asp Val Ile Asp Ala Phe His Ala Ala Thr 
            100                 105                 110         


<210>  8
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  pknGU-F primer

<400>  8
tcgtggtgtc ggtggtcaac t                                               21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  pknGU-R primer

<400>  9
gcccttgctc ttcttggtgg a                                               21


<210>  10
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  pknGD-F primer

<400>  10
cacatcctgg gcttcccgtt ca                                              22


<210>  11
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  pknGD-R primer

<400>  11
tacctgcggc tgctgctcat cg                                              22


<210>  12
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  lsr2U-F primer

<400>  12
tagaaatgta cccgtcgctg tc                                              22


<210>  13
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  lsr2U-R primer

<400>  13
tttgccattg gcttaccctc                                                 20


<210>  14
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  lsr2D-F primer

<400>  14
ccttccacgc cgcaacct                                                   18


<210>  15
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  lsr2D-R primer

<400>  15
ggctcagctc cagcaccttc                                                 20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  relASU-F primer

<400>  16
cgaccgaatc gctcaagacg                                                 20


<210>  17
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  relASU-R primer

<400>  17
gcgaacgaca ggtcctccaa c                                               21


<210>  18
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  relASD-F primer

<400>  18
gcagtggttc gccaaggag                                                  19


<210>  19
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  relASD-R primer

<400>  19
gggtcgccca tctcaaagg                                                  19


<210>  20
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  relALU-F primer

<400>  20
aagaagatgt acgcggtgag c                                               21


<210>  21
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  relALU-R primer

<400>  21
cttgagcgat tcggtcgg                                                   18


<210>  22
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  relALD-F primer

<400>  22
atcgaccaga ccgaggagga c                                               21


<210>  23
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  relALD-R primer

<400>  23
ccacagacca acggcaagg                                                  19


<210>  24
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  delta relAS primer relL-3F

<400>  24
ttcggaggtg agcatcgtgg                                                 20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  delta relAS primer relR-3R

<400>  25
ccgacaacgg gtcctgctac                                                 20


<210>  26
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  delta lsr2 primer lsrL-1F

<400>  26
ccccaatgtt gcagacgc                                                   18


<210>  27
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  delta lsr2 primer lsrR-1R

<400>  27
tcacccgctc gatttcctt                                                  19


<210>  28
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  left side of delta pknG; primer pknL-1F

<400>  28
accagaactg cgacctgacg g                                               21


<210>  29
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  hyg-R  primer

<400>  29
gccctacctg gtgatgagcc                                                 20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  right side of delta pknG; primer hyg-F

<400>  30
cacgaagatg ttggtcccgt                                                 20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  pknR-1R

<400>  31
tccaccacaa cactcgtgcc                                                 20


<210>  32
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  left side of delta relAL; primer relL-1F

<400>  32
caggtggaca acgcgatcg                                                  19


<210>  33
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  relR2R primer

<400>  33
tgcgtcgttg atgagggtt                                                  19


<210>  34
<211>  927
<212>  DNA
<213>  Mycobacterium avium

<400>  34
gtgaaacccg ccttcaccgc gggcgaactc aacacctaca ccagcccggg cgacgtcacc     60

gccgtcagcc gcgcgctgcg ccacaccggc cgccgggtga tgctggtgcc caccatgggt    120

gcgctgcacg acggccacct cgcgctggtg cgggcggcca agcgggtgcc cggttcggtg    180

gtggtggtgt cgatcttcgt caacccgctg caattcggcg ccggcgaaga cctggacgcc    240

tacccccgca ccctggacga cgacctggcg ctgctgcgct ccgagggcgt cgaaatcgcc    300

ttcaccccaa cggccgcggc gatgtacccg aatggtttgc gcaccaccgt gcagcccggc    360

ccgctggccg ccgagctgga gggcgggccc cggccgacgc atttcgccgg cgtgctgacc    420

gtcgtgtgca agctgctgca gatcgtgcgc ccggaccgaa tcttcttcgg cgagaaggac    480

taccagcagc tggtgatgat ccgtcagatg gtcgccgacc tcaacatcga cgtgcaggtg    540

gtcggggtgc cgaccgtgcg ggaggccgac ggcctggcga tgtcgtcgcg caaccgctac    600

ctggacgcca cgcaacgcga actggccgtg acgctttcgg cggccctgac cgccggcgcg    660

cacgccgctc acctgggcgg tgcggccgcg ctgcgggccg cgcgggcggt gctggacgcc    720

gtgcccgagc tcaccgtcga ctatctcgag ctgcgcgacg ccgggctggg cccggcaccc    780

gcccacggct cggcgcggct gctggtcgcc gcccggctgg gcaacacccg actgctggat    840

aacatcgaaa tgcagatcga aacacccgcc ggcaccgctg ggccggacgg cgaccgccaa    900

tacgcccaat caccttggag gaattga                                        927


<210>  35
<211>  308
<212>  PRT
<213>  Mycobacterium avium

<400>  35

Met Lys Pro Ala Phe Thr Ala Gly Glu Leu Asn Thr Tyr Thr Ser Pro 
1               5                   10                  15      


Gly Asp Val Thr Ala Val Ser Arg Ala Leu Arg His Thr Gly Arg Arg 
            20                  25                  30          


Val Met Leu Val Pro Thr Met Gly Ala Leu His Asp Gly His Leu Ala 
        35                  40                  45              


Leu Val Arg Ala Ala Lys Arg Val Pro Gly Ser Val Val Val Val Ser 
    50                  55                  60                  


Ile Phe Val Asn Pro Leu Gln Phe Gly Ala Gly Glu Asp Leu Asp Ala 
65                  70                  75                  80  


Tyr Pro Arg Thr Leu Asp Asp Asp Leu Ala Leu Leu Arg Ser Glu Gly 
                85                  90                  95      


Val Glu Ile Ala Phe Thr Pro Thr Ala Ala Ala Met Tyr Pro Asn Gly 
            100                 105                 110         


Leu Arg Thr Thr Val Gln Pro Gly Pro Leu Ala Ala Glu Leu Glu Gly 
        115                 120                 125             


Gly Pro Arg Pro Thr His Phe Ala Gly Val Leu Thr Val Val Cys Lys 
    130                 135                 140                 


Leu Leu Gln Ile Val Arg Pro Asp Arg Ile Phe Phe Gly Glu Lys Asp 
145                 150                 155                 160 


Tyr Gln Gln Leu Val Met Ile Arg Gln Met Val Ala Asp Leu Asn Ile 
                165                 170                 175     


Asp Val Gln Val Val Gly Val Pro Thr Val Arg Glu Ala Asp Gly Leu 
            180                 185                 190         


Ala Met Ser Ser Arg Asn Arg Tyr Leu Asp Ala Thr Gln Arg Glu Leu 
        195                 200                 205             


Ala Val Thr Leu Ser Ala Ala Leu Thr Ala Gly Ala His Ala Ala His 
    210                 215                 220                 


Leu Gly Gly Ala Ala Ala Leu Arg Ala Ala Arg Ala Val Leu Asp Ala 
225                 230                 235                 240 


Val Pro Glu Leu Thr Val Asp Tyr Leu Glu Leu Arg Asp Ala Gly Leu 
                245                 250                 255     


Gly Pro Ala Pro Ala His Gly Ser Ala Arg Leu Leu Val Ala Ala Arg 
            260                 265                 270         


Leu Gly Asn Thr Arg Leu Leu Asp Asn Ile Glu Met Gln Ile Glu Thr 
        275                 280                 285             


Pro Ala Gly Thr Ala Gly Pro Asp Gly Asp Arg Gln Tyr Ala Gln Ser 
    290                 295                 300                 


Pro Trp Arg Asn 
305             


<210>  36
<211>  432
<212>  DNA
<213>  Mycobacterium avium

<400>  36
atgttacgga cgatgctcaa gtcgaagatc caccgggcca ccgtcacgca ggccgacctg     60

cactacgtgg gctcggtgac catcgacgcc gacctgatgg acgccgccga cctgctcgag    120

ggcgaacagg tgaccatcgt cgacatcgac aacggcgccc ggctggtcac ctacgcgatc    180

accggtgagc gtggcagcgg ggtgatcggg atcaacggtg ccgcagcgca tctggtccac    240

ccgggcgatc tggtcatcct gatcgcgtat gggaccatgg aggaggccga ggcgcgggcg    300

tatcagccgc gaatcgtctt cgtcgacgcc gacaacaagc cggtcgacct cggccacgat    360

ccggcattcg tgccggactt cgagatagca ggggcggccg agctgctcga tccccggatc    420

gttgcgcggt ag                                                        432


<210>  37
<211>  143
<212>  PRT
<213>  Mycobacterium avium

<400>  37

Met Leu Arg Thr Met Leu Lys Ser Lys Ile His Arg Ala Thr Val Thr 
1               5                   10                  15      


Gln Ala Asp Leu His Tyr Val Gly Ser Val Thr Ile Asp Ala Asp Leu 
            20                  25                  30          


Met Asp Ala Ala Asp Leu Leu Glu Gly Glu Gln Val Thr Ile Val Asp 
        35                  40                  45              


Ile Asp Asn Gly Ala Arg Leu Val Thr Tyr Ala Ile Thr Gly Glu Arg 
    50                  55                  60                  


Gly Ser Gly Val Ile Gly Ile Asn Gly Ala Ala Ala His Leu Val His 
65                  70                  75                  80  


Pro Gly Asp Leu Val Ile Leu Ile Ala Tyr Gly Thr Met Glu Glu Ala 
                85                  90                  95      


Glu Ala Arg Ala Tyr Gln Pro Arg Ile Val Phe Val Asp Ala Asp Asn 
            100                 105                 110         


Lys Pro Val Asp Leu Gly His Asp Pro Ala Phe Val Pro Asp Phe Glu 
        115                 120                 125             


Ile Ala Gly Ala Ala Glu Leu Leu Asp Pro Arg Ile Val Ala Arg 
    130                 135                 140             


<210>  38
<211>  897
<212>  DNA
<213>  Mycobacterium avium

<400>  38
gtgtctgcga tgctgtccgg catggcaaga atcgcaatca tcggtggcgg cagcatcggg     60

gaggccctgc tgtcgggtct gctgcgggcg ggccggcagg tcaaggacct ggtggtggtc    120

gagcgggttc ccgagcgcgc caaatatctg gccgacacct actcggtgct gatcacctcg    180

gtggccgacg cggtggaaaa cgcgtcgttc gtcgtggtcg cggtgaaacc ggccgacgtc    240

gagtcggtga tgtccgagat cgcccgcgcc gccggccagg ccgagagcga caccgccgag    300

caggtgttcg tcacggtcgc cgccggggtc accatcggct acttcgaatc ccggctgccg    360

gccgggacac cggtggtgcg ggccatgccg aacgcggccg tgctggtcgg cgccggggtc    420

accgccctgg ccaagggccg cttcgtcacc gccccgcagc tcgagggcgt ctcggcgctg    480

ttcgactcgg tcgggggcgt gctgagcgtg ccggagagcc agatggacgc cgtcaccgcc    540

ctctccggct ccgggccggc gtatttcttc ctgctggtgg aggccctggt ggacgccggg    600

gtggccgcgg gcctgagccg cgaggtggcc gccgacctga ccgcccagac catggccggc    660

tcggcggcga tgctgctgga gcggatggac gccgatcggc gactgggcga ggcggagacg    720

cccgggctgc gggtggacgc caccgccacc cagctgcggg ccacggtgac ctccccgggc    780

ggcaccaccg cggccggcct gcgcgagctg gagcgggggg gcctgcgggc cgccgtcgac    840

gccgccgtcc aggccgccaa aatgcgctct gagcagctaa gaattacatc ggagtaa       897


<210>  39
<211>  298
<212>  PRT
<213>  Mycobacterium avium

<400>  39

Met Ser Ala Met Leu Ser Gly Met Ala Arg Ile Ala Ile Ile Gly Gly 
1               5                   10                  15      


Gly Ser Ile Gly Glu Ala Leu Leu Ser Gly Leu Leu Arg Ala Gly Arg 
            20                  25                  30          


Gln Val Lys Asp Leu Val Val Val Glu Arg Val Pro Glu Arg Ala Lys 
        35                  40                  45              


Tyr Leu Ala Asp Thr Tyr Ser Val Leu Ile Thr Ser Val Ala Asp Ala 
    50                  55                  60                  


Val Glu Asn Ala Ser Phe Val Val Val Ala Val Lys Pro Ala Asp Val 
65                  70                  75                  80  


Glu Ser Val Met Ser Glu Ile Ala Arg Ala Ala Gly Gln Ala Glu Ser 
                85                  90                  95      


Asp Thr Ala Glu Gln Val Phe Val Thr Val Ala Ala Gly Val Thr Ile 
            100                 105                 110         


Gly Tyr Phe Glu Ser Arg Leu Pro Ala Gly Thr Pro Val Val Arg Ala 
        115                 120                 125             


Met Pro Asn Ala Ala Val Leu Val Gly Ala Gly Val Thr Ala Leu Ala 
    130                 135                 140                 


Lys Gly Arg Phe Val Thr Ala Pro Gln Leu Glu Gly Val Ser Ala Leu 
145                 150                 155                 160 


Phe Asp Ser Val Gly Gly Val Leu Ser Val Pro Glu Ser Gln Met Asp 
                165                 170                 175     


Ala Val Thr Ala Leu Ser Gly Ser Gly Pro Ala Tyr Phe Phe Leu Leu 
            180                 185                 190         


Val Glu Ala Leu Val Asp Ala Gly Val Ala Ala Gly Leu Ser Arg Glu 
        195                 200                 205             


Val Ala Ala Asp Leu Thr Ala Gln Thr Met Ala Gly Ser Ala Ala Met 
    210                 215                 220                 


Leu Leu Glu Arg Met Asp Ala Asp Arg Arg Leu Gly Glu Ala Glu Thr 
225                 230                 235                 240 


Pro Gly Leu Arg Val Asp Ala Thr Ala Thr Gln Leu Arg Ala Thr Val 
                245                 250                 255     


Thr Ser Pro Gly Gly Thr Thr Ala Ala Gly Leu Arg Glu Leu Glu Arg 
            260                 265                 270         


Gly Gly Leu Arg Ala Ala Val Asp Ala Ala Val Gln Ala Ala Lys Met 
        275                 280                 285             


Arg Ser Glu Gln Leu Arg Ile Thr Ser Glu 
    290                 295             


<210>  40
<211>  1104
<212>  DNA
<213>  Mycobacterium avium

<400>  40
tcagagctgc tgaccgaacc gcacccaacg cgcgagcagc tgttcggccg cgccggagtc     60

gatggcggcg ctggcgcggg ccagcccgtc ctcccaggcc ggcaaccatt cggcgcggct    120

ggataacccg gcgtgcgcca cgatcgcgcc ggcggcgttg aggacgacgg cgtcgcgcac    180

cgggccctgg ccgccggcca gcaccgcccg cacctccgcg gcgttggtct gcgcgtcacc    240

gcccaacaga tcgtcgagct cggcccgcgg gaaaccgaac ccggccggat cgaacgtcaa    300

ccggtccacc gtgccggcct gcacccgcca gatggtgctg gtcgtcgtgg tggtcaactc    360

gtcgagcccg tcgtcgccgt gcaccaccag cacactggag cgccgggcgg cgaacacccc    420

ggccatcacc tcggccagct cggcgaacgc gcagccgatc aatccggccc gcggtcgagc    480

cggattggta agcggcccaa gcagattgaa caccgtcggc acgccgatct cgcggcgcac    540

cgccgaggta tgccggtagg acgggtggaa cagcggcgcg aagcagaatc cgatgccgac    600

ttcggcgaca ctgcgcgcga cctgctcggg gcccaggtcg atccgtaccc cgagctcctc    660

gagcgtgtcc gcgccgcccg agagcgacga cgccgcgcgg ttgccgtgtt tgaccaccgg    720

tacccccgcg gccgcggcca cgatcgccgc catcgtggac aggttgaggg tgttgacgcc    780

gtcgccgccg gtgccgacga tgtcgacggt gtcgtcgcgg atcgcgccgg cggggaacgg    840

cagcgcgtgg ttcagcatca cctcggccag ctcgatgacc tcggccgagg tggggacctt    900

cacctgcatc gccaccgcga aggccgcgat ctgggccggg ctcgcctcgc cggtcatgat    960

ctggtccatg gcccaggccg cctgtccgcg ggccaggtcg tcaccgccgg tcagccgggc   1020

cagcacctgg cgccacgacg tcgccggccc accggagggc cgccgggctg cggaagccgc   1080

agacgactca gatgacaacg ccac                                          1104


<210>  41
<211>  367
<212>  PRT
<213>  Mycobacterium avium

<400>  41

Met Ala Leu Ser Ser Glu Ser Ser Ala Ala Ser Ala Ala Arg Arg Pro 
1               5                   10                  15      


Ser Gly Gly Pro Ala Thr Ser Trp Arg Gln Val Leu Ala Arg Leu Thr 
            20                  25                  30          


Gly Gly Asp Asp Leu Ala Arg Gly Gln Ala Ala Trp Ala Met Asp Gln 
        35                  40                  45              


Ile Met Thr Gly Glu Ala Ser Pro Ala Gln Ile Ala Ala Phe Ala Val 
    50                  55                  60                  


Ala Met Gln Val Lys Val Pro Thr Ser Ala Glu Val Ile Glu Leu Ala 
65                  70                  75                  80  


Glu Val Met Leu Asn His Ala Leu Pro Phe Pro Ala Gly Ala Ile Arg 
                85                  90                  95      


Asp Asp Thr Val Asp Ile Val Gly Thr Gly Gly Asp Gly Val Asn Thr 
            100                 105                 110         


Leu Asn Leu Ser Thr Met Ala Ala Ile Val Ala Ala Ala Ala Gly Val 
        115                 120                 125             


Pro Val Val Lys His Gly Asn Arg Ala Ala Ser Ser Leu Ser Gly Gly 
    130                 135                 140                 


Ala Asp Thr Leu Glu Glu Leu Gly Val Arg Ile Asp Leu Gly Pro Glu 
145                 150                 155                 160 


Gln Val Ala Arg Ser Val Ala Glu Val Gly Ile Gly Phe Cys Phe Ala 
                165                 170                 175     


Pro Leu Phe His Pro Ser Tyr Arg His Thr Ser Ala Val Arg Arg Glu 
            180                 185                 190         


Ile Gly Val Pro Thr Val Phe Asn Leu Leu Gly Pro Leu Thr Asn Pro 
        195                 200                 205             


Ala Arg Pro Arg Ala Gly Leu Ile Gly Cys Ala Phe Ala Glu Leu Ala 
    210                 215                 220                 


Glu Val Met Ala Gly Val Phe Ala Ala Arg Arg Ser Ser Val Leu Val 
225                 230                 235                 240 


Val His Gly Asp Asp Gly Leu Asp Glu Leu Thr Thr Thr Thr Thr Ser 
                245                 250                 255     


Thr Ile Trp Arg Val Gln Ala Gly Thr Val Asp Arg Leu Thr Phe Asp 
            260                 265                 270         


Pro Ala Gly Phe Gly Phe Pro Arg Ala Glu Leu Asp Asp Leu Leu Gly 
        275                 280                 285             


Gly Asp Ala Gln Thr Asn Ala Ala Glu Val Arg Ala Val Leu Ala Gly 
    290                 295                 300                 


Gly Gln Gly Pro Val Arg Asp Ala Val Val Leu Asn Ala Ala Gly Ala 
305                 310                 315                 320 


Ile Val Ala His Ala Gly Leu Ser Ser Arg Ala Glu Trp Leu Pro Ala 
                325                 330                 335     


Trp Glu Asp Gly Leu Ala Arg Ala Ser Ala Ala Ile Asp Ser Gly Ala 
            340                 345                 350         


Ala Glu Gln Leu Leu Ala Arg Trp Val Arg Phe Gly Gln Gln Leu 
        355                 360                 365         


<210>  42
<211>  903
<212>  DNA
<213>  Mycobacterium avium

<400>  42
gtgtcgcgcg aaaatcgaag tcgcagaagg ctgatcggcg gcgcataccg aagcctgcgg     60

ctgctcggcg ccgtggccgc ggtggcgctg gcggccagcc cgttgacacc gcgcaccagc    120

cttgcggcag cggccattcc gcaaccgtcg cacatcgtga tcgtggtgga ggaaaaccgt    180

tccgagagcg gcatcatcgg caacaagtcg gcgcccttca tcaccgcgct ggccgcgtcc    240

ggcgccaaca tgacccagtc gttcgccgaa acccacccca gcgagcccaa ttacctggcg    300

ctgttcgccg gcaacacgtt cggggtgacc aaggacctgt gcccggtcaa cgccggcgcc    360

gcacccaacc tggggtccga attgctcgcc gccggttaca cattcgtcgg ctacgccgag    420

ggcctgccgt ccccgggctc accggtgtgt agtgcgggca agtacgcgcg aaaacatgtg    480

ccgtgggcca acttcaccaa cgtgccggcg gctagctcgc tgccgttctc ggcgttcccg    540

atgggcaact acgccagcct gccgacggtg tcgttcgtca tcccgaacaa cgacaacaac    600

atgcacgacg gctcgatcgc gcaggccgac tcctggctga accggcagct gtccggctac    660

gccaattggg cgctggccaa caacagcctg ctgatcgtca ccttcgacga ggacgacaac    720

tccaacgtcg gagccagccg caaccagatc cccacggtgt tctacggcgc ccacgtccgg    780

cccggcaact acgccgagca gatcaaccac tacaacgtgc ttgccaccct cgagcagatg    840

tacgggctgc ccaagacggg ctatgccgcc ggcgccgccc ccatcaccga catctggggc    900

tga                                                                  903


<210>  43
<211>  300
<212>  PRT
<213>  Mycobacterium avium

<400>  43

Met Ser Arg Glu Asn Arg Ser Arg Arg Arg Leu Ile Gly Gly Ala Tyr 
1               5                   10                  15      


Arg Ser Leu Arg Leu Leu Gly Ala Val Ala Ala Val Ala Leu Ala Ala 
            20                  25                  30          


Ser Pro Leu Thr Pro Arg Thr Ser Leu Ala Ala Ala Ala Ile Pro Gln 
        35                  40                  45              


Pro Ser His Ile Val Ile Val Val Glu Glu Asn Arg Ser Glu Ser Gly 
    50                  55                  60                  


Ile Ile Gly Asn Lys Ser Ala Pro Phe Ile Thr Ala Leu Ala Ala Ser 
65                  70                  75                  80  


Gly Ala Asn Met Thr Gln Ser Phe Ala Glu Thr His Pro Ser Glu Pro 
                85                  90                  95      


Asn Tyr Leu Ala Leu Phe Ala Gly Asn Thr Phe Gly Val Thr Lys Asp 
            100                 105                 110         


Leu Cys Pro Val Asn Ala Gly Ala Ala Pro Asn Leu Gly Ser Glu Leu 
        115                 120                 125             


Leu Ala Ala Gly Tyr Thr Phe Val Gly Tyr Ala Glu Gly Leu Pro Ser 
    130                 135                 140                 


Pro Gly Ser Pro Val Cys Ser Ala Gly Lys Tyr Ala Arg Lys His Val 
145                 150                 155                 160 


Pro Trp Ala Asn Phe Thr Asn Val Pro Ala Ala Ser Ser Leu Pro Phe 
                165                 170                 175     


Ser Ala Phe Pro Met Gly Asn Tyr Ala Ser Leu Pro Thr Val Ser Phe 
            180                 185                 190         


Val Ile Pro Asn Asn Asp Asn Asn Met His Asp Gly Ser Ile Ala Gln 
        195                 200                 205             


Ala Asp Ser Trp Leu Asn Arg Gln Leu Ser Gly Tyr Ala Asn Trp Ala 
    210                 215                 220                 


Leu Ala Asn Asn Ser Leu Leu Ile Val Thr Phe Asp Glu Asp Asp Asn 
225                 230                 235                 240 


Ser Asn Val Gly Ala Ser Arg Asn Gln Ile Pro Thr Val Phe Tyr Gly 
                245                 250                 255     


Ala His Val Arg Pro Gly Asn Tyr Ala Glu Gln Ile Asn His Tyr Asn 
            260                 265                 270         


Val Leu Ala Thr Leu Glu Gln Met Tyr Gly Leu Pro Lys Thr Gly Tyr 
        275                 280                 285             


Ala Ala Gly Ala Ala Pro Ile Thr Asp Ile Trp Gly 
    290                 295                 300 


<210>  44
<211>  1334
<212>  DNA
<213>  Mycobacterium avium

<400>  44
ctacccgcgg tcgcgggcca gcaggtcggc cacggtttcg cggcggacca gttcccgggc     60

ccggccctcg ctgaccgcca ccagcggcgg gcgcccgacc atgttgtagt tcgacgccat    120

gctgtggtgg taggcgccgg tgcaggccac ggccagcagg tcacccgggc gcagatcggc    180

gggcagctcg acgtcgcggg cgatctcgtc gccggactcg cagtgccggc ccgccaccgt    240

gacccgctgc ttgaggccca gcggatgccg gttggccagc gcgacggcat accgcgcgcc    300

gtacagcgac acccgcgggt tgtcgctcat gccgccgtcg acggcgacga aggtccgccc    360

gccgccttgc gtcttcaccg agcacacccg gtacagggtc accccggccc gaccgctgat    420

cgcccggccc ggctccacca cgatctgcgg gcgggggaac cgctcggcgg cgcacgcctc    480

gtccagggcg tcctcgatca cgtcggccag ctggtcgagg ttcagctccg ggtcgccgga    540

cgcatacgga atggcatgtc ccccaccgat attcagctcg gtcaggatga cgccgtgccg    600

ggcccggata tcggccatcg cggcgatcat ccggcggatc gcctcgccgt acagggcggg    660

gtcggacacc tgcgagccga ggtggcagtg caggccgacc aggtcgagga tggggtgggc    720

cagcacccgg cgcaccgcgt cggccgcgtg gtcgccggcc agggtgaagc cgaacttctg    780

gtcgctgacg ccggtggtga cggcgcgatg cccgtggatg tcgatgtcgg gggtgacccg    840

gatgagcacc ggctggcggc gacgggccag gccggccaga tacgcgatct cgatggtcga    900

atccagcacg atgcggccca ccccgacgcg caccgcctcg cgcagctcct cgggcgattt    960

cgcgttgccg tgcatgacga tgcgggccgg gtcgaccccg ccggccagcg cggtggccag   1020

ttcaccggcc gagcagacgt cgacgccgag gcgctcctcg cgggcccacc gggccaccgc   1080

ggtgctcagc agggacttgc cggcgtagac cacctcgacg ccgcgcagcg ccctgcggta   1140

ccggcgggcg cggcaccgga agtcggcttc gtcgacgacg taggccgggg tgccgaactc   1200

gtcggcgacg tcgcccagcg gcacgccgcc gacgcacagc cggccctcct cgtcgggatg   1260

ggcggtgacg ggccagatcg ccggatcgaa ccgtggggga gccgcgtgac ccagcgacgg   1320

caggatgtcc agca                                                     1334


<210>  45
<211>  444
<212>  PRT
<213>  Mycobacterium avium

<400>  45

Met Leu Asp Ile Leu Pro Ser Leu Gly His Ala Ala Pro Pro Arg Phe 
1               5                   10                  15      


Asp Pro Ala Ile Trp Pro Val Thr Ala His Pro Asp Glu Glu Gly Arg 
            20                  25                  30          


Leu Cys Val Gly Gly Val Pro Leu Gly Asp Val Ala Asp Glu Phe Gly 
        35                  40                  45              


Thr Pro Ala Tyr Val Val Asp Glu Ala Asp Phe Arg Cys Arg Ala Arg 
    50                  55                  60                  


Arg Tyr Arg Arg Ala Leu Arg Gly Val Glu Val Val Tyr Ala Gly Lys 
65                  70                  75                  80  


Ser Leu Leu Ser Thr Ala Val Ala Arg Trp Ala Arg Glu Glu Arg Leu 
                85                  90                  95      


Gly Val Asp Val Cys Ser Ala Gly Glu Leu Ala Thr Ala Leu Ala Gly 
            100                 105                 110         


Gly Val Asp Pro Ala Arg Ile Val Met His Gly Asn Ala Lys Ser Pro 
        115                 120                 125             


Glu Glu Leu Arg Glu Ala Val Arg Val Gly Val Gly Arg Ile Val Leu 
    130                 135                 140                 


Asp Ser Thr Ile Glu Ile Ala Tyr Leu Ala Gly Leu Ala Arg Arg Arg 
145                 150                 155                 160 


Gln Pro Val Leu Ile Arg Val Thr Pro Asp Ile Asp Ile His Gly His 
                165                 170                 175     


Arg Ala Val Thr Thr Gly Val Ser Asp Gln Lys Phe Gly Phe Thr Leu 
            180                 185                 190         


Ala Gly Asp His Ala Ala Asp Ala Val Arg Arg Val Leu Ala His Pro 
        195                 200                 205             


Ile Leu Asp Leu Val Gly Leu His Cys His Leu Gly Ser Gln Val Ser 
    210                 215                 220                 


Asp Pro Ala Leu Tyr Gly Glu Ala Ile Arg Arg Met Ile Ala Ala Met 
225                 230                 235                 240 


Ala Asp Ile Arg Ala Arg His Gly Val Ile Leu Thr Glu Leu Asn Ile 
                245                 250                 255     


Gly Gly Gly His Ala Ile Pro Tyr Ala Ser Gly Asp Pro Glu Leu Asn 
            260                 265                 270         


Leu Asp Gln Leu Ala Asp Val Ile Glu Asp Ala Leu Asp Glu Ala Cys 
        275                 280                 285             


Ala Ala Glu Arg Phe Pro Arg Pro Gln Ile Val Val Glu Pro Gly Arg 
    290                 295                 300                 


Ala Ile Ser Gly Arg Ala Gly Val Thr Leu Tyr Arg Val Cys Ser Val 
305                 310                 315                 320 


Lys Thr Gln Gly Gly Gly Arg Thr Phe Val Ala Val Asp Gly Gly Met 
                325                 330                 335     


Ser Asp Asn Pro Arg Val Ser Leu Tyr Gly Ala Arg Tyr Ala Val Ala 
            340                 345                 350         


Leu Ala Asn Arg His Pro Leu Gly Leu Lys Gln Arg Val Thr Val Ala 
        355                 360                 365             


Gly Arg His Cys Glu Ser Gly Asp Glu Ile Ala Arg Asp Val Glu Leu 
    370                 375                 380                 


Pro Ala Asp Leu Arg Pro Gly Asp Leu Leu Ala Val Ala Cys Thr Gly 
385                 390                 395                 400 


Ala Tyr His His Ser Met Ala Ser Asn Tyr Asn Met Val Gly Arg Pro 
                405                 410                 415     


Pro Leu Val Ala Val Ser Glu Gly Arg Ala Arg Glu Leu Val Arg Arg 
            420                 425                 430         


Glu Thr Val Ala Asp Leu Leu Ala Arg Asp Arg Gly 
        435                 440                 


<210>  46
<211>  603
<212>  DNA
<213>  Mycobacterium avium

<400>  46
tcacgcgacg ggcgaagtgc gcggtttcca atcgggatac gtcgcttcgt aggattcgat     60

tctgtcgagt ttccgcagcg taagggctat atcgtcgagc ccttcgagta gtcgccacgc    120

ggtgtggtcg tcaatcttga acggcagcac cgtcgttccc gcggtgatat ttcgatcttg    180

aagattggca gtgatttcca agccggggct ctgctcgatg agcttccaga gcagctccac    240

cccgtcctgg gaaacttcgg ccgccagcag acccgccttg ccggcgttgc cccggaaaat    300

gtcgccgaat cgagacgaga tgaccacccg gaacccgtag tccatcagtg cccacaccgc    360

gtgctcgcgc gacgaccccg tcccgaaatc cggtccggcg actaggactg agccacggtc    420

aaaggggctg aggttgagca cgaatgacgg atccgaccgc cagctggcga acaagccgtc    480

ctcgaaaccg gttcgggtta cgcgcttcaa atacaccgcc ggaatgatct ggtcggtgtc    540

gacattggag cgccgcagcg gcacaccgat gccggtgtgg gtgtgaaatg cttccatgct    600

cat                                                                  603


<210>  47
<211>  200
<212>  PRT
<213>  Mycobacterium avium

<400>  47

Met Ser Met Glu Ala Phe His Thr His Thr Gly Ile Gly Val Pro Leu 
1               5                   10                  15      


Arg Arg Ser Asn Val Asp Thr Asp Gln Ile Ile Pro Ala Val Tyr Leu 
            20                  25                  30          


Lys Arg Val Thr Arg Thr Gly Phe Glu Asp Gly Leu Phe Ala Ser Trp 
        35                  40                  45              


Arg Ser Asp Pro Ser Phe Val Leu Asn Leu Ser Pro Phe Asp Arg Gly 
    50                  55                  60                  


Ser Val Leu Val Ala Gly Pro Asp Phe Gly Thr Gly Ser Ser Arg Glu 
65                  70                  75                  80  


His Ala Val Trp Ala Leu Met Asp Tyr Gly Phe Arg Val Val Ile Ser 
                85                  90                  95      


Ser Arg Phe Gly Asp Ile Phe Arg Gly Asn Ala Gly Lys Ala Gly Leu 
            100                 105                 110         


Leu Ala Ala Glu Val Ser Gln Asp Gly Val Glu Leu Leu Trp Lys Leu 
        115                 120                 125             


Ile Glu Gln Ser Pro Gly Leu Glu Ile Thr Ala Asn Leu Gln Asp Arg 
    130                 135                 140                 


Asn Ile Thr Ala Gly Thr Thr Val Leu Pro Phe Lys Ile Asp Asp His 
145                 150                 155                 160 


Thr Ala Trp Arg Leu Leu Glu Gly Leu Asp Asp Ile Ala Leu Thr Leu 
                165                 170                 175     


Arg Lys Leu Asp Arg Ile Glu Ser Tyr Glu Ala Thr Tyr Pro Asp Trp 
            180                 185                 190         


Lys Pro Arg Thr Ser Pro Val Ala 
        195                 200 


<210>  48
<211>  1431
<212>  DNA
<213>  Mycobacterium avium

<400>  48
tcagtccaaa tcggccggag cggacaatgt gccgcgcacc gccgtggccg cggcgacggc     60

cggagacacc aaatgcgtgc ggccgccttt gccctggcgc ccttcgaagt tgcggttcga    120

ggtcgccgcg caccgctccc ccggcgccag ctgatcggga ttcattccca aacacatcga    180

gcagcccgcc tgccgccatt cggcgcccgc ggcggtgaaa acctcgccca gcccttcggc    240

ttcggcctgc gcgcgcaccc gcatcgagcc gggcaccacg agcatccgca cccccggcgc    300

gaccttgcgg ccgcgcagca cgtcggcgac gacccgcaga tcctcgatac gaccgttggt    360

acaagagccg acgaacaccg cgtcgaccgc gatgtcgcgc atcggcgtgc ccggtcgaag    420

gtccatgtat gccaacgctt tctcggcggc ctgacgctcg gcatcgtcgg tcatcagttc    480

gggatccggt accgcggcag ccaacggcac gccctgaccc gggtttgtgc cccacgtcac    540

gaacgggctc agcgacgcgg catccagata gacctcggtg tcgaacaccg cgccgggatc    600

ggtgcgcagc tgctgccaat agcgcatggc cgcatcccat tgcgcgccct tgggggcgtg    660

cgggcggtcc cgcaggaact cgtaggtggt gtcgtcggga gcgatcatcc ccgctcgggc    720

accggcctcg atgctcatgt tgcacacggt catccggcct tccatcgaca gcgattcgat    780

ggcgctgccg cggtattcga tgacgtgccc ctgcccgccg ccggtgccga tcttggcgat    840

cagcgccagg atgatgtcct tggccgtcac gccggccggc aactcgccgt cgacgttgac    900

cgccatcgtc ttgaacggcc gcagcggcaa cgtctgggtg gccagcacgt gctcgacctc    960

cgaggtgcca attcccatgg ccagtgcgcc gaatgcgccg tgcgtcgagg tgtgactatc   1020

cccacacacc accgtcattc ccggttgggt caggcccagc tgcggcccga cgacatgcac   1080

gatgccctgc tccgcgtcgc ccatcgggta cagccggacg ccgaattcgg cacaatttcg   1140

gcgcaatgtc tcgacctggg tgcgcgacac cgggtcggcg atcggcttgt cgatgtcgac   1200

ggtgggcacg ttgtggtcct cggtggccag cgtcagatcg ggccgccgca ccggccggcc   1260

ggccagccgc aggccgtcga acgcctgcgg gctggtgacc tcgtgcacca ggtgcagatc   1320

gatgtagatc aggtccggct cgttggcccc gccggacacc acaacgtggt cgtcccagac   1380

tttttcggcc agcgtgcgcg gcgtggccgt cgtccccgtg tcgattccca t            1431


<210>  49
<211>  476
<212>  PRT
<213>  Mycobacterium avium

<400>  49

Met Gly Ile Asp Thr Gly Thr Thr Ala Thr Pro Arg Thr Leu Ala Glu 
1               5                   10                  15      


Lys Val Trp Asp Asp His Val Val Val Ser Gly Gly Ala Asn Glu Pro 
            20                  25                  30          


Asp Leu Ile Tyr Ile Asp Leu His Leu Val His Glu Val Thr Ser Pro 
        35                  40                  45              


Gln Ala Phe Asp Gly Leu Arg Leu Ala Gly Arg Pro Val Arg Arg Pro 
    50                  55                  60                  


Asp Leu Thr Leu Ala Thr Glu Asp His Asn Val Pro Thr Val Asp Ile 
65                  70                  75                  80  


Asp Lys Pro Ile Ala Asp Pro Val Ser Arg Thr Gln Val Glu Thr Leu 
                85                  90                  95      


Arg Arg Asn Cys Ala Glu Phe Gly Val Arg Leu Tyr Pro Met Gly Asp 
            100                 105                 110         


Ala Glu Gln Gly Ile Val His Val Val Gly Pro Gln Leu Gly Leu Thr 
        115                 120                 125             


Gln Pro Gly Met Thr Val Val Cys Gly Asp Ser His Thr Ser Thr His 
    130                 135                 140                 


Gly Ala Phe Gly Ala Leu Ala Met Gly Ile Gly Thr Ser Glu Val Glu 
145                 150                 155                 160 


His Val Leu Ala Thr Gln Thr Leu Pro Leu Arg Pro Phe Lys Thr Met 
                165                 170                 175     


Ala Val Asn Val Asp Gly Glu Leu Pro Ala Gly Val Thr Ala Lys Asp 
            180                 185                 190         


Ile Ile Leu Ala Leu Ile Ala Lys Ile Gly Thr Gly Gly Gly Gln Gly 
        195                 200                 205             


His Val Ile Glu Tyr Arg Gly Ser Ala Ile Glu Ser Leu Ser Met Glu 
    210                 215                 220                 


Gly Arg Met Thr Val Cys Asn Met Ser Ile Glu Ala Gly Ala Arg Ala 
225                 230                 235                 240 


Gly Met Ile Ala Pro Asp Asp Thr Thr Tyr Glu Phe Leu Arg Asp Arg 
                245                 250                 255     


Pro His Ala Pro Lys Gly Ala Gln Trp Asp Ala Ala Met Arg Tyr Trp 
            260                 265                 270         


Gln Gln Leu Arg Thr Asp Pro Gly Ala Val Phe Asp Thr Glu Val Tyr 
        275                 280                 285             


Leu Asp Ala Ala Ser Leu Ser Pro Phe Val Thr Trp Gly Thr Asn Pro 
    290                 295                 300                 


Gly Gln Gly Val Pro Leu Ala Ala Ala Val Pro Asp Pro Glu Leu Met 
305                 310                 315                 320 


Thr Asp Asp Ala Glu Arg Gln Ala Ala Glu Lys Ala Leu Ala Tyr Met 
                325                 330                 335     


Asp Leu Arg Pro Gly Thr Pro Met Arg Asp Ile Ala Val Asp Ala Val 
            340                 345                 350         


Phe Val Gly Ser Cys Thr Asn Gly Arg Ile Glu Asp Leu Arg Val Val 
        355                 360                 365             


Ala Asp Val Leu Arg Gly Arg Lys Val Ala Pro Gly Val Arg Met Leu 
    370                 375                 380                 


Val Val Pro Gly Ser Met Arg Val Arg Ala Gln Ala Glu Ala Glu Gly 
385                 390                 395                 400 


Leu Gly Glu Val Phe Thr Ala Ala Gly Ala Glu Trp Arg Gln Ala Gly 
                405                 410                 415     


Cys Ser Met Cys Leu Gly Met Asn Pro Asp Gln Leu Ala Pro Gly Glu 
            420                 425                 430         


Arg Cys Ala Ala Thr Ser Asn Arg Asn Phe Glu Gly Arg Gln Gly Lys 
        435                 440                 445             


Gly Gly Arg Thr His Leu Val Ser Pro Ala Val Ala Ala Ala Thr Ala 
    450                 455                 460                 


Val Arg Gly Thr Leu Ser Ala Pro Ala Asp Leu Asp 
465                 470                 475     


