                         SEQUENCE LISTING

<110>  Basi, Guriqbal
       Shapiro, Paul
       Ren, Zhao
 
<120>  Compositions and Methods for Identifying Substrate Specificity of
        Inhibitors of Gamma Secretase

<130>  07-108-WO

<150>  60/949738
<151>  2007-07-13

<160>  103   

<170>  PatentIn version 3.4

<210>  1
<211>  99
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr 
        35                  40                  45              


Leu Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val 
    50                  55                  60                  


Val Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys 
65                  70                  75                  80  


Met Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln 
                85                  90                  95      


Met Gln Asn 
            


<210>  2
<211>  230
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2

Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys 
1               5                   10                  15      


Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys 
            20                  25                  30          


Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu 
        35                  40                  45              


Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu 
    50                  55                  60                  


Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu 
65                  70                  75                  80  


Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe 
                85                  90                  95      


Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser 
            100                 105                 110         


Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala 
        115                 120                 125             


Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr 
    130                 135                 140                 


Val Ser Gly Ile Pro Gly Asp Leu Ala Pro Pro Thr Asp Val Ser Leu 
145                 150                 155                 160 


Gly Asp Glu Leu His Leu Asp Gly Glu Asp Val Ala Met Ala His Ala 
                165                 170                 175     


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Asp Gly Asp Ser 
            180                 185                 190         


Pro Gly Pro Gly Phe Thr Pro His Asp Ser Ala Pro Tyr Gly Ala Leu 
        195                 200                 205             


Asp Met Ala Asp Phe Glu Phe Glu Gln Met Phe Thr Asp Ala Leu Gly 
    210                 215                 220                 


Ile Asp Glu Tyr Gly Gly 
225                 230 


<210>  3
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3

Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  4

Leu Glu Glu Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  5

Pro Tyr Lys Ile Glu Ala Val Gln Ser Glu Thr Val Glu Pro Pro 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  6

Ala Lys Pro Glu Gln Arg Pro Ser Leu His Ser Arg Gly Met Leu 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  7

His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly His Ser Thr Leu Pro 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  8

Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile Lys Ser Tyr Leu Glu 
1               5                   10                  15  


<210>  9
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  9

Val Thr Thr Val Met Gly Ser Ser Pro Val Val Thr Arg Gly 
1               5                   10                  


<210>  10
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  10

His Gly Lys Ile His Leu Gln Val Leu Met Glu Glu Pro Pro Glu 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  11

Leu Arg Val Lys Val Cys Gln Cys Asp Ser Asn Gly Asp Cys Thr 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  12

Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro 
1               5                   10                  15  


<210>  13
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  13

Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val 
1               5                   10                  15      


Ile Val Ile Thr Leu Val Met Leu 
            20                  


<210>  14
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  14

Asp Ala Glu Phe Arg His Asp Ser Gly 
1               5                   


<210>  15
<211>  54
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  15

Leu Glu Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His 
1               5                   10                  15      


Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala 
            20                  25                  30          


Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val 
        35                  40                  45              


Ile Thr Leu Val Met Leu 
    50                  


<210>  16
<211>  54
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  16

Leu Glu Asp Ala Glu Phe Arg His Asp Ser Gly Leu Glu Glu Glu Arg 
1               5                   10                  15      


Glu Ser Val Gly Pro Leu Arg Glu Asp Phe Ser Leu Ser Ser Gly Ala 
            20                  25                  30          


Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val 
        35                  40                  45              


Ile Thr Leu Val Met Leu 
    50                  


<210>  17
<211>  54
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  17

Leu Glu Asp Ala Glu Phe Arg His Asp Ser Gly Pro Tyr Lys Ile Glu 
1               5                   10                  15      


Ala Val Gln Ser Glu Thr Val Glu Pro Pro Pro Pro Ala Gln Gly Ala 
            20                  25                  30          


Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val 
        35                  40                  45              


Ile Thr Leu Val Met Leu 
    50                  


<210>  18
<211>  54
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  18

Leu Glu Asp Ala Glu Phe Arg His Asp Ser Gly Ala Lys Pro Glu Gln 
1               5                   10                  15      


Arg Pro Ser Leu His Ser Arg Gly Met Leu Asp Arg Ser Arg Gly Ala 
            20                  25                  30          


Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val 
        35                  40                  45              


Ile Thr Leu Val Met Leu 
    50                  


<210>  19
<211>  54
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  19

Leu Glu Asp Ala Glu Phe Arg His Asp Ser Gly Leu Glu Glu Glu Arg 
1               5                   10                  15      


Glu Ser Val Gly Pro Leu Arg Glu Asp Phe Gly Ser Asn Lys Gly Ala 
            20                  25                  30          


Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val 
        35                  40                  45              


Ile Thr Leu Val Met Leu 
    50                  


<210>  20
<211>  54
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  20

Leu Glu Asp Ala Glu Phe Arg His Asp Ser Gly Pro Tyr Lys Ile Glu 
1               5                   10                  15      


Ala Val Gln Ser Glu Thr Val Glu Pro Pro Gly Ser Asn Lys Gly Ala 
            20                  25                  30          


Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val 
        35                  40                  45              


Ile Thr Leu Val Met Leu 
    50                  


<210>  21
<211>  54
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  21

Leu Glu Asp Ala Glu Phe Arg His Asp Ser Gly Ala Lys Pro Glu Gln 
1               5                   10                  15      


Arg Pro Ser Leu His Ser Arg Gly Met Leu Gly Ser Asn Lys Gly Ala 
            20                  25                  30          


Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val 
        35                  40                  45              


Ile Thr Leu Val Met Leu 
    50                  


<210>  22
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  22

Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Gly 
1               5                   10                  15      


Ser Asn Lys 
            


<210>  23
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  23

Leu Glu Glu Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe Ser 
1               5                   10                  15      


Leu Ser Ser 
            


<210>  24
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  24

Pro Tyr Lys Ile Glu Ala Val Gln Ser Glu Thr Val Glu Pro Pro Pro 
1               5                   10                  15      


Pro Ala Gln 
            


<210>  25
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  25

Ala Lys Pro Glu Gln Arg Pro Ser Leu His Ser Arg Gly Met Leu Asp 
1               5                   10                  15      


Arg Ser Arg 
            


<210>  26
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  26

Val Thr Thr Val Met Gly Ser Ser Pro Val Val Thr Arg Gly Thr Thr 
1               5                   10                  15      


Asp Asn 
        


<210>  27
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  27

Leu Arg Val Lys Val Cys Gln Cys Asp Ser Asn Gly Asp Cys Thr Asp 
1               5                   10                  15      


Val Asp Arg 
            


<210>  28
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  28

His Gly Lys Ile His Leu Gln Val Leu Met Glu Glu Pro Pro Glu Arg 
1               5                   10                  15      


Asp Ser Thr 
            


<210>  29
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  29

Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile Lys Ser Tyr Leu Glu Gln 
1               5                   10                  15      


Ala Ser Arg 
            


<210>  30
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  30

Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln 
1               5                   10                  15      


Ile Pro Glu 
            


<210>  31
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  31

Leu Glu Glu Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe Gly 
1               5                   10                  15      


Ser Asn Lys 
            


<210>  32
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  32

Pro Tyr Lys Ile Glu Ala Val Gln Ser Glu Thr Val Glu Pro Pro Gly 
1               5                   10                  15      


Ser Asn Lys 
            


<210>  33
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  33

Ala Lys Pro Glu Gln Arg Pro Ser Leu His Ser Arg Gly Met Leu Gly 
1               5                   10                  15      


Ser Asn Lys 
            


<210>  34
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  34

Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Ser 
1               5                   10                  15      


Leu Ser Ser 
            


<210>  35
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  35

Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Asp 
1               5                   10                  15      


Arg Ser Arg 
            


<210>  36
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  36

Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Pro 
1               5                   10                  15      


Pro Ala Gln 
            


<210>  37
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  37

Leu Glu Asp Ala Glu Phe Arg His Asp Ser Gly 
1               5                   10      


<210>  38
<211>  88
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  38

Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn 
1               5                   10                  15      


Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr 
            20                  25                  30          


Val Ile Val Ile Thr Leu Val Met Leu Lys Lys Lys Gln Tyr Thr Ser 
        35                  40                  45              


Ile His His Gly Val Val Glu Val Asp Ala Ala Val Thr Pro Glu Glu 
    50                  55                  60                  


Arg His Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr 
65                  70                  75                  80  


Lys Phe Phe Glu Gln Met Gln Asn 
                85              


<210>  39
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  39

Val Met Leu Lys Lys Lys Cys 
1               5           


<210>  40
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  40

Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met 
1               5                   10              


<210>  41
<211>  50
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  41

Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val 
1               5                   10                  15      


Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met 
            20                  25                  30          


Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met 
        35                  40                  45              


Gln Asn 
    50  


<210>  42
<211>  54
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  42

Leu Glu Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His 
1               5                   10                  15      


Gln Lys Leu Val Phe Phe Ala Glu Asp Val Ser Leu Ser Ser Gly Ala 
            20                  25                  30          


Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val 
        35                  40                  45              


Ile Thr Leu Val Met Leu 
    50                  


<210>  43
<211>  54
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  43

Leu Glu Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His 
1               5                   10                  15      


Gln Lys Leu Val Phe Phe Ala Glu Asp Val Ser Ser Asn Lys Gly Ala 
            20                  25                  30          


Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val 
        35                  40                  45              


Ile Thr Leu Val Met Leu 
    50                  


<210>  44
<211>  54
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  44

Leu Glu Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His 
1               5                   10                  15      


Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Leu Asn Lys Gly Ala 
            20                  25                  30          


Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val 
        35                  40                  45              


Ile Thr Leu Val Met Leu 
    50                  


<210>  45
<211>  54
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  45

Leu Glu Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His 
1               5                   10                  15      


Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Ser Lys Gly Ala 
            20                  25                  30          


Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val 
        35                  40                  45              


Ile Thr Leu Val Met Leu 
    50                  


<210>  46
<211>  54
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  46

Leu Glu Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His 
1               5                   10                  15      


Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Ser Gly Ala 
            20                  25                  30          


Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val 
        35                  40                  45              


Ile Thr Leu Val Met Leu 
    50                  


<210>  47
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  47

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr 
        35                  40                  45              


Leu Val Met Leu Lys Lys Lys Lys Leu Leu Ser Ser Ile Glu Gln Ala 
    50                  55                  60                  


Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro 
65                  70                  75                  80  


Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro 
                85                  90                  95      


Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu 
            100                 105                 110         


Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg 
        115                 120                 125             


Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys 
    130                 135                 140                 


Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala 
145                 150                 155                 160 


Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu 
                165                 170                 175     


Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn 
            180                 185                 190         


Lys Gly Gln Arg Gln Leu Thr Val Ser Gly Ile Pro Gly Asp Leu Ala 
        195                 200                 205             


Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp Gly Glu 
    210                 215                 220                 


Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
225                 230                 235                 240 


Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro His Asp 
                245                 250                 255     


Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe Glu Gln 
            260                 265                 270         


Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly Gln Tyr Thr 
        275                 280                 285             


Ser Ile His His Gly Val Val Glu Val Asp Ala Ala Val Thr Pro Glu 
    290                 295                 300                 


Glu Arg His Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn Pro Thr 
305                 310                 315                 320 


Tyr Lys Phe Phe Glu Gln Met Gln Asn 
                325                 


<210>  48
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  48

Asp Ala Glu Phe Arg His Asp Ser Gly Leu Glu Glu Glu Arg Glu Ser 
1               5                   10                  15      


Val Gly Pro Leu Arg Glu Asp Phe Ser Leu Ser Ser Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr 
        35                  40                  45              


Leu Val Met Leu Lys Lys Lys Lys Leu Leu Ser Ser Ile Glu Gln Ala 
    50                  55                  60                  


Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro 
65                  70                  75                  80  


Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro 
                85                  90                  95      


Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu 
            100                 105                 110         


Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg 
        115                 120                 125             


Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys 
    130                 135                 140                 


Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala 
145                 150                 155                 160 


Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu 
                165                 170                 175     


Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn 
            180                 185                 190         


Lys Gly Gln Arg Gln Leu Thr Val Ser Gly Ile Pro Gly Asp Leu Ala 
        195                 200                 205             


Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp Gly Glu 
    210                 215                 220                 


Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
225                 230                 235                 240 


Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro His Asp 
                245                 250                 255     


Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe Glu Gln 
            260                 265                 270         


Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly Gln Tyr Thr 
        275                 280                 285             


Ser Ile His His Gly Val Val Glu Val Asp Ala Ala Val Thr Pro Glu 
    290                 295                 300                 


Glu Arg His Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn Pro Thr 
305                 310                 315                 320 


Tyr Lys Phe Phe Glu Gln Met Gln Asn 
                325                 


<210>  49
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  49

Asp Ala Glu Phe Arg His Asp Ser Gly Pro Tyr Lys Ile Glu Ala Val 
1               5                   10                  15      


Gln Ser Glu Thr Val Glu Pro Pro Pro Pro Ala Gln Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr 
        35                  40                  45              


Leu Val Met Leu Lys Lys Lys Lys Leu Leu Ser Ser Ile Glu Gln Ala 
    50                  55                  60                  


Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro 
65                  70                  75                  80  


Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro 
                85                  90                  95      


Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu 
            100                 105                 110         


Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg 
        115                 120                 125             


Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys 
    130                 135                 140                 


Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala 
145                 150                 155                 160 


Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu 
                165                 170                 175     


Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn 
            180                 185                 190         


Lys Gly Gln Arg Gln Leu Thr Val Ser Gly Ile Pro Gly Asp Leu Ala 
        195                 200                 205             


Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp Gly Glu 
    210                 215                 220                 


Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
225                 230                 235                 240 


Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro His Asp 
                245                 250                 255     


Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe Glu Gln 
            260                 265                 270         


Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly Gln Tyr Thr 
        275                 280                 285             


Ser Ile His His Gly Val Val Glu Val Asp Ala Ala Val Thr Pro Glu 
    290                 295                 300                 


Glu Arg His Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn Pro Thr 
305                 310                 315                 320 


Tyr Lys Phe Phe Glu Gln Met Gln Asn 
                325                 


<210>  50
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  50

Asp Ala Glu Phe Arg His Asp Ser Gly Pro Tyr Lys Ile Glu Ala Val 
1               5                   10                  15      


Gln Ser Glu Thr Val Glu Pro Pro Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr 
        35                  40                  45              


Leu Val Met Leu Lys Lys Lys Lys Leu Leu Ser Ser Ile Glu Gln Ala 
    50                  55                  60                  


Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro 
65                  70                  75                  80  


Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro 
                85                  90                  95      


Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu 
            100                 105                 110         


Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg 
        115                 120                 125             


Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys 
    130                 135                 140                 


Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala 
145                 150                 155                 160 


Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu 
                165                 170                 175     


Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn 
            180                 185                 190         


Lys Gly Gln Arg Gln Leu Thr Val Ser Gly Ile Pro Gly Asp Leu Ala 
        195                 200                 205             


Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp Gly Glu 
    210                 215                 220                 


Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
225                 230                 235                 240 


Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro His Asp 
                245                 250                 255     


Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe Glu Gln 
            260                 265                 270         


Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly Gln Tyr Thr 
        275                 280                 285             


Ser Ile His His Gly Val Val Glu Val Asp Ala Ala Val Thr Pro Glu 
    290                 295                 300                 


Glu Arg His Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn Pro Thr 
305                 310                 315                 320 


Tyr Lys Phe Phe Glu Gln Met Gln Asn 
                325                 


<210>  51
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  51

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Ser Leu Ser Ser Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr 
        35                  40                  45              


Leu Val Met Leu Lys Lys Lys Lys Leu Leu Ser Ser Ile Glu Gln Ala 
    50                  55                  60                  


Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro 
65                  70                  75                  80  


Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro 
                85                  90                  95      


Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu 
            100                 105                 110         


Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg 
        115                 120                 125             


Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys 
    130                 135                 140                 


Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala 
145                 150                 155                 160 


Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu 
                165                 170                 175     


Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn 
            180                 185                 190         


Lys Gly Gln Arg Gln Leu Thr Val Ser Gly Ile Pro Gly Asp Leu Ala 
        195                 200                 205             


Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp Gly Glu 
    210                 215                 220                 


Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
225                 230                 235                 240 


Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro His Asp 
                245                 250                 255     


Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe Glu Gln 
            260                 265                 270         


Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly Gln Tyr Thr 
        275                 280                 285             


Ser Ile His His Gly Val Val Glu Val Asp Ala Ala Val Thr Pro Glu 
    290                 295                 300                 


Glu Arg His Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn Pro Thr 
305                 310                 315                 320 


Tyr Lys Phe Phe Glu Gln Met Gln Asn 
                325                 


<210>  52
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  52
cggctcgggc gctggaggat gcagaattcc gacatgactc aggatatgaa gttcatcatc     60


<210>  53
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  53
tggcactgct cctgctggcc gcctggacgg ctcgggcgct ggaggatgca g              51


<210>  54
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  54
caccaccatg ctgcccggtt tggcactgct cctgctggcc gcctggac                  48


<210>  55
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  55
gcggccgcct agttctgcat ctgctcaaag aac                                  33


<210>  56
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  56
ccgtgggccc actgcgggag gacttcagtc tgagtagcgg tgcaatcatt ggactcatgg     60


<210>  57
<211>  59
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  57
tcccgcagtg ggcccacgga ttcccgctct tcctcgagtc ctgagtcatg tcggaattc      59


<210>  58
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  58
tgcagagtga gaccgtggag ccgcccccgc cggcgcaggg tgcaatcatt ggactcatgg     60


<210>  59
<211>  59
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  59
tccacggtct cactctgcac ggcctcgatc ttgtagggtc ctgagtcatg tcggaattc      59


<210>  60
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  60
cgtctctgca cagccggggc atgctggacc gctcccgcgg tgcaatcatt ggactcatgg     60


<210>  61
<211>  59
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  61
ccccggctgt gcagagacgg ccgctgctct ggctttgctc ctgagtcatg tcggaattc      59


<210>  62
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  62
cgggtcacca cgggctggga gctgcccatc actgtggtca ctcctgagtc atgtcggaat     60

tct                                                                   63


<210>  63
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  63
gcagctccca gcccgtggtg acccgaggca ccaccgacaa cggtgcaatc attggactca     60

tggt                                                                  64


<210>  64
<211>  65
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  64
cagtccccgt tggagtcaca ctggcaaacc ttcacgcgca gtcctgagtc atgtcggaat     60

tctgc                                                                 65


<210>  65
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  65
ttgccagtgt gactccaacg gggactgcac agatgtggac aggggtgcaa tcattggact     60

catggt                                                                66


<210>  66
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  66
taaagtggaa tggcccgtcc atgggtagta aatgcagtca tgtcctgagt catgtcggaa     60

ttctgc                                                                66


<210>  67
<211>  65
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  67
tacccatgga cgggccattc cactttacca caacatgcta gaggtgcaat cattggactc     60

atggt                                                                 65


<210>  68
<211>  70
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  68
gttccaaata ggacttaatg tagtcttgaa aagagtctgg gtctgatcct gagtcatgtc     60

ggaattctgc                                                            70


<210>  69
<211>  67
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  69
cttttcaaga ctacattaag tcctatttgg aacaagcgag tcggggtgca atcattggac     60

tcatggt                                                               67


<210>  70
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  70
agggggctct tccatgagga cctgcagatg gatcttgcca tgtcctgagt catgtcggaa     60

ttctgc                                                                66


<210>  71
<211>  65
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  71
ctgcaggtcc tcatggaaga gccccctgag cgggactcca cgggtgcaat cattggactc     60

atggt                                                                 65


<210>  72
<211>  55
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  72
cgggcgctgg aggatgcaga attcgcagct gcctcaggat atgaagttca tcatc          55


<210>  73
<211>  55
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  73
gatgatgaac ttcatatcct gaggcagctg cgaattctgc atcctccagc gcccg          55


<210>  74
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  74
gttgctgctc aagcattggt gttctttgca gaagatgtgg gttc                      44


<210>  75
<211>  58
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  75
gaacaccaat gcttgagcag caacttcata tcctgagtca tgtcggaatt ctgcatcc       58


<210>  76
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  76
ggtgttcttt gcagcagctg tgggttcaaa caaaggtgc                            39


<210>  77
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  77
gcacctttgt ttgaacccac agctgctgca aagaacacc                            39


<210>  78
<211>  59
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  78
ccgtgggccc actgcgggag gacttcggtt caaacaaagg tgcaatcatt ggactcatg      59


<210>  79
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  79
tgcagagtga gaccgtggag ccgcccggtt caaacaaagg tgcaatcatt ggactcatgg     60


<210>  80
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  80
cgtctctgca cagccggggc atgctgggtt caaacaaagg tgcaatcatt ggactcatgg     60


<210>  81
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  81
agaagatgtg agtctgagta gcggtgcaat cattggactc atggtgggc                 49


<210>  82
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  82
tgcaccgcta ctcagactca catcttctgc aaagaacacc aatttttgat gatgaac        57


<210>  83
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  83
ggtgttcttt gcagaagatg tgagttcaaa caaaggtgca atcattgg                  48


<210>  84
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  84
ccaatgattg cacctttgtt tgaactcaca tcttctgcaa agaacacc                  48


<210>  85
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  85
ggtgttcttt gcagaagatg tgggtttaaa caaaggtgca atcattggac                50


<210>  86
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  86
gtccaatgat tgcacctttg tttaaaccca catcttctgc aaagaacacc                50


<210>  87
<211>  52
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  87
ggtgttcttt gcagaagatg tgggttcaag caaaggtgca atcattggac tc             52


<210>  88
<211>  52
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  88
gagtccaatg attgcacctt tgcttgaacc cacatcttct gcaaagaaca cc             52


<210>  89
<211>  56
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  89
ggtgttcttt gcagaagatg tgggttcaaa ctcaggtgca atcattggac tcatgg         56


<210>  90
<211>  56
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  90
ccatgagtcc aatgattgca cctgagtttg aacccacatc ttctgcaaag aacacc         56


<210>  91
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  91

Thr Val Ile Val Ile Thr Leu Val Met Leu Lys Lys Lys Gln Thr Tyr 
1               5                   10                  15      


Thr Ser 
        


<210>  92
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  92

Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser Gly Leu Thr Asn Ile 
1               5                   10                  15      


Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp Ala Glu Phe Arg His 
            20                  25                  30          


Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu 
        35                  40                  45              


Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly 
    50                  55                  60                  


Val Val Ile Ala Thr Val Ile Val Ile Thr Leu Val Met Leu Lys Lys 
65                  70                  75                  80  


Lys Gln Tyr Thr Ser Ile His His Gly Val Val Glu Val Asp Ala Ala 
                85                  90                  95      


Val Thr Pro Glu Glu Arg His Leu Ser Lys Met Gln Gln Asn Gly Tyr 
            100                 105                 110         


Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met Gln Asn 
        115                 120                 125 


<210>  93
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  93

Cys Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met 
1               5                   10                  


<210>  94
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  94

Gln His Ala Arg 
1               


<210>  95
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  95

Gln Ala Ser Arg 
1               


<210>  96
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  96

Thr Thr Asp Asn 
1               


<210>  97
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  97

Arg Asp Ser Thr 
1               


<210>  98
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  98

Asp Val Asp Arg 
1               


<210>  99
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  99

Gln Ile Pro Glu 
1               


<210>  100
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  100

Pro Pro Ala Gln 
1               


<210>  101
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  101

Asp Arg Ser Arg 
1               


<210>  102
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  102

Ser Leu Ser Ser 
1               


<210>  103
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  103

Gly Ser Asn Lys 
1               


