                         SEQUENCE LISTING

<110>  Tweten, Rodney K
 
<120>  H-ANTIGEN BINDING POLYPEPTIDES AND METHODS OF USE

<130>  5835.098wo

<150>  12/102,696
<151>  2008-04-18

<150>  60/961,135
<151>  2007-07-19

<160>  25    

<170>  PatentIn version 3.3

<210>  1
<211>  665
<212>  PRT
<213>  Streptococcus mitis

<400>  1

Met Asn Gln Glu Lys Arg Leu His Arg Phe Val Lys Lys Cys Gly Leu 
1               5                   10                  15      


Gly Val Cys Ser Ala Val Val Ala Ala Phe Leu Leu Asn Ala Gln Gly 
            20                  25                  30          


Val Ala Leu Ala Thr Glu Gln Gly Asn Arg Pro Val Glu Thr Glu Asn 
        35                  40                  45              


Ile Ala Arg Gly Lys Gln Ala Ser Gln Ser Ser Thr Ala Tyr Gly Gly 
    50                  55                  60                  


Ala Ala Thr Arg Ala Val Asp Gly Asn Val Asp Ser Asp Tyr Gly His 
65                  70                  75                  80  


His Ser Val Thr His Thr Asn Phe Glu Asp Asn Ala Trp Trp Gln Val 
                85                  90                  95      


Asp Leu Gly Lys Thr Glu Asn Val Gly Lys Val Lys Leu Tyr Asn Arg 
            100                 105                 110         


Gly Asp Gly Asn Val Ala Asn Arg Leu Ser Asn Phe Asp Val Val Leu 
        115                 120                 125             


Leu Asn Glu Ala Lys Gln Glu Val Ala Arg Gln His Phe Asp Ser Leu 
    130                 135                 140                 


Asn Gly Lys Ala Glu Leu Glu Val Phe Phe Thr Ala Lys Asp Ala Arg 
145                 150                 155                 160 


Tyr Val Lys Val Glu Leu Lys Thr Lys Asn Thr Pro Leu Ser Leu Ala 
                165                 170                 175     


Glu Val Glu Val Phe Arg Ser Ala Thr Thr Gln Val Gly Gln Asp Arg 
            180                 185                 190         


Thr Ala Pro Val Val Asp Gln Thr Ser Ala Leu Lys Asp Tyr Leu Phe 
        195                 200                 205             


Gly Leu Thr Tyr Asn Pro Leu Asp Ile Leu Thr Arg Lys Gly Glu Thr 
    210                 215                 220                 


Leu Glu Asn Arg Tyr Asn Thr Ser Ala Lys Glu Gln Asn Gly Glu Phe 
225                 230                 235                 240 


Val Val Val Glu Lys Ile Lys Lys Thr Leu Ser Thr Gly Thr Ala Asp 
                245                 250                 255     


Val Ser Ile Asn Gly Asn Gln Asn Val Phe Leu Gly Gly Leu Tyr Lys 
            260                 265                 270         


Ala Asn Gln Asn Leu Leu Glu Asn Gln Pro Glu Leu Ile Ser Leu Ala 
        275                 280                 285             


Arg Ala Lys Gly Thr Val Ser Val Asp Leu Pro Gly Met Ile His Ser 
    290                 295                 300                 


Glu Asn Lys Ile Glu Ala Asn Pro Thr Thr Ser Gly Met Gln Glu Ala 
305                 310                 315                 320 


Met Asn Thr Leu Val Glu Lys Trp Thr Lys Asn Tyr Ser Ser Ser His 
                325                 330                 335     


Ser Val Pro Ala Arg Val Gln Tyr Glu Ser Thr Thr Ala Tyr Ser Met 
            340                 345                 350         


Asn Gln Leu Lys Ala Lys Phe Gly Ala Asp Phe Glu Lys Ala Gly Ala 
        355                 360                 365             


Pro Leu Lys Ile Asp Phe Glu Ala Val Gln Lys Gly Glu Lys Gln Ile 
    370                 375                 380                 


Glu Val Val Asn Phe Lys Gln Ile Tyr Tyr Thr Ala Thr Phe Asp Ala 
385                 390                 395                 400 


Pro Thr Asn Pro Ala Ala Val Phe Asp Lys Ser Val Thr Pro Glu Asp 
                405                 410                 415     


Leu Lys Gln Arg Gly Val Asp Ser Gln Thr Pro Pro Val Tyr Val Ser 
            420                 425                 430         


Asn Val Ser Tyr Gly Arg Gln Ile Tyr Val Lys Phe Glu Ser Thr Ser 
        435                 440                 445             


Lys Ser Thr Glu Leu Lys Ala Ala Ile Asn Ala Val Ile Lys Gly Ala 
    450                 455                 460                 


Thr Ile Ala Pro Asn Ser Glu Trp Ser Arg Leu Leu Lys Asn Thr Ser 
465                 470                 475                 480 


Val Thr Ala Val Ile Val Gly Gly Asn Ala Ser Gly Ala Ala Lys Val 
                485                 490                 495     


Val Thr Gly Thr Val Glu Asn Leu Lys Glu Leu Ile Arg Glu Gly Ala 
            500                 505                 510         


Asn Phe Ser Ala Gln Ser Pro Ala Val Pro Ile Ser Tyr Lys Thr Ala 
        515                 520                 525             


Phe Leu Lys Asp Asn Ala Gln Ala Thr Leu Gln Asn Ser Thr Asp Tyr 
    530                 535                 540                 


Ile Glu Thr Lys Val Thr Ser Tyr Lys Asn Gly Phe Leu Lys Leu His 
545                 550                 555                 560 


His Lys Gly Ala Tyr Ile Ala Arg Tyr Tyr Ile Tyr Trp Asp Glu Ile 
                565                 570                 575     


Thr Tyr Asp Glu Gln Gly Asn Pro Glu Ile Arg Ser Arg Gln Trp Glu 
            580                 585                 590         


Asp Asn Gly Lys Asn Arg Thr Ser Gly Phe Gln Thr Glu Ile Gln Phe 
        595                 600                 605             


Arg Gly Asn Val Arg Asn Leu Arg Ile Lys Val Gln Glu Lys Thr Gly 
    610                 615                 620                 


Leu Val Trp Glu Pro Trp Arg Thr Val Tyr Asn Arg Thr Asp Leu Pro 
625                 630                 635                 640 


Leu Val Gln Gln Arg Thr Ile Thr His Trp Gly Thr Thr Leu Asn Pro 
                645                 650                 655     


Lys Val Asp Glu Lys Ile Val Asn Glu 
            660                 665 


<210>  2
<211>  1998
<212>  DNA
<213>  Streptococcus mitis

<400>  2
atgaatcaag aaaaacgttt gcatcgcttt gtcaaaaagt gtggactcgg tgtgtgtagt     60

gctgttgttg cggccttttt attgaacgct cagggagtag ctttggctac agagcaaggg    120

aatcgtccag ttgagaccaa aaacatcgct cgtggaaaac aagctagtca aagttctact    180

gcttatggag gagctgctac acgagcagtg gacggtaatg ttgacagtga ctatgggcac    240

cattctgtaa cgcacacaaa ctttgaagac aatgcttggt ggcaagttga tcttggaaaa    300

acagagaatg ttggaaaagt taaactctac aatcgtggag atgggaatgt agctaatcgt    360

ctttccaatt ttgatgttgt tttgttaaat gaagcaaaac aagaagttgc tcgtcaacac    420

tttgatagtt tgaatgggaa ggcagaactt gaagttttct tcaccgccaa agacgctcgt    480

tatgtaaaag tggagttgaa aactaaaaat accccattga gcttggcaga agtggaagta    540

ttccgttcag caacaactca agttggacag gatagaactg caccagtagt agatcaaaca    600

tcagcattga aagactacct ttttggctta acttataatc ctttggatat tttaactcgc    660

aagggagaaa ccttagaaaa tcgctacaac acaagtgcta aggaacaaaa tggagagttt    720

gtcgttgtag aaaaaatcaa gaaaaccctc tctacaggca cagcagatgt ttccatcaat    780

ggaaatcaaa atgtcttcct aggtggcttg tataaggcaa accaaaatct gctagaaaat    840

cagccagaat tgattagtct tgcccgtgca aaggggacag tcagcgtcga tttacctggt    900

atgattcact ctgaaaacaa aattgaagca aatcctacaa ctagtggtat gcaggaggcg    960

atgaatacct tggttgaaag atggacaaag aattactcat ctagccattc cgttcctgcc   1020

cgtgttcagt atgaatcaac tacagcctat agcatgaatc aattgaaagc aaaatttggt   1080

gcagactttg aaaaagcagg tgcaccgctc aagattgact ttgaggctgt gcaaaagggt   1140

gaaaagcaaa ttgaagttgt aaactttaaa caaatctact atacagcgac atttgatgca   1200

ccgaccaatc cagcggctgt atttgacaag agtgtgacac ctgaagattt aaaacaaaga   1260

ggcgttgatt cacaaactcc acctgtatat gtatcaaatg tttcttacgg acgtcaaatc   1320

tatgttaagt ttgagtcaac aagtaagtct actgaattaa aagcagctat taatgcggtt   1380

atcaaaggcg caacaattgc tccaaattct gaatggagcc gtctattgaa gaatacttct   1440

gtaacagcgg taattgtagg aggtaatgct agcggtgccg ccaaagttgt cacaggaaca   1500

gtcgaaaact tgaaggaact catcagagaa ggagctaact ttagcgctca aagtccagct   1560

gtgccaatct catataagac tgccttccta aaagataatg cccaagcaac tttacaaaat   1620

agtacagact atatcgaaac gaaggttact tcttacaaaa atggtttctt gaaacttcat   1680

cataagggtg cttatattgc gcgttactac atctattggg atgaaattac atatgatgaa   1740

caaggaaatc cagaaatccg ttcacgtcaa tgggaagata acggaaaaaa cagaacttca   1800

ggcttccaaa cagagattca atttagagga aatgtccgta atcttcgcat caaggttcaa   1860

gaaaagacgg gtcttgtatg ggaaccatgg cgtacagttt acaaccgcac agacttacca   1920

ctagtacaac agcgtacaat tacacattgg ggaacaactc taaaccctaa agttgatgaa   1980

aaaattgtga atgagtaa                                                 1998


<210>  3
<211>  162
<212>  PRT
<213>  Streptococcus mitis

<400>  3

Thr Glu Gln Gly Asn Arg Pro Val Glu Thr Glu Asn Ile Ala Arg Gly 
1               5                   10                  15      


Lys Gln Ala Ser Gln Ser Ser Thr Ala Tyr Gly Gly Ala Ala Thr Arg 
            20                  25                  30          


Ala Val Asp Gly Asn Val Asp Ser Asp Tyr Gly His His Ser Val Thr 
        35                  40                  45              


His Thr Asn Phe Glu Asp Asn Ala Trp Trp Gln Val Asp Leu Gly Lys 
    50                  55                  60                  


Thr Glu Asn Val Gly Lys Val Lys Leu Tyr Asn Arg Gly Asp Gly Asn 
65                  70                  75                  80  


Val Ala Asn Arg Leu Ser Asn Phe Asp Val Val Leu Leu Asn Glu Ala 
                85                  90                  95      


Lys Gln Glu Val Ala Arg Gln His Phe Asp Ser Leu Asn Gly Lys Ala 
            100                 105                 110         


Glu Leu Glu Val Phe Phe Thr Ala Lys Asp Ala Arg Tyr Val Lys Val 
        115                 120                 125             


Glu Leu Lys Thr Lys Asn Thr Pro Leu Ser Leu Ala Glu Val Glu Val 
    130                 135                 140                 


Phe Arg Ser Ala Thr Thr Gln Val Gly Gln Asp Arg Thr Ala Pro Val 
145                 150                 155                 160 


Val Asp 
        


<210>  4
<211>  486
<212>  DNA
<213>  Streptococcus mitis

<400>  4
acagagcaag ggaatcgtcc agttgagacc gaaaacatcg ctcgtggaaa acaagctagt     60

caaagttcta ctgcttatgg aggagctgct gcacgagcag tggacggtaa tgttgacagt    120

gactatgggc accattctgt aacgcacaca aactttgaag acaatgcttg gtggcaagtt    180

gatcttggaa aaacagagaa tgttggaaaa gttaaactct acaatcgtgg agatgggaat    240

gtagctaatc gtctttccaa ttttgatgtt gttttgttaa atgaagcaaa acaagaagtt    300

gctcgtcaac actttgatag tttgaatggg aaggcagaac ttgaagtttt cttcaccgcc    360

aaagccgctc gttatgtaaa agtggagttg aaaactaaaa ataccccatt gagcttggca    420

gaagtggaag tattccgttc agcaacaact caagttggac aggatagaac tgcaccagta    480

gtagat                                                               486


<210>  5
<211>  39
<212>  DNA
<213>  Streptococcus mitis

<400>  5
atgaatcaag aaaaacgttt gcatcgcttt gtcaaaaag                            39


<210>  6
<211>  39
<212>  DNA
<213>  Streptococcus mitis

<400>  6
ttactcattc acaatttttt catcaacttt agggtttag                            39


<210>  7
<211>  30
<212>  DNA
<213>  Streptococcus mitis

<400>  7
tcggatccga gcaagggaat cgtccagttg                                      30


<210>  8
<211>  42
<212>  DNA
<213>  Streptococcus mitis

<400>  8
ctgaattctt actcattcac aattttttca tcaactttag gg                        42


<210>  9
<211>  532
<212>  PRT
<213>  Streptococcus intermedius

<400>  9

Met Lys Thr Lys Gln Asn Ile Ala Arg Lys Leu Ser Arg Val Val Leu 
1               5                   10                  15      


Leu Ser Thr Leu Val Leu Ser Ser Ala Ala Pro Ile Ser Ala Ala Phe 
            20                  25                  30          


Ala Glu Thr Pro Thr Lys Pro Lys Ala Ala Gln Thr Glu Lys Lys Pro 
        35                  40                  45              


Glu Lys Lys Pro Glu Asn Ser Asn Ser Glu Ala Ala Lys Lys Ala Leu 
    50                  55                  60                  


Asn Asp Tyr Ile Trp Gly Leu Gln Tyr Asp Lys Leu Asn Ile Leu Thr 
65                  70                  75                  80  


His Gln Gly Glu Lys Leu Lys Asn His Ser Ser Arg Glu Ala Phe His 
                85                  90                  95      


Arg Pro Gly Glu Tyr Val Val Ile Glu Lys Lys Lys Gln Ser Ile Ser 
            100                 105                 110         


Asn Ala Thr Ser Lys Leu Ser Val Ser Ser Ala Asn Asp Asp Arg Ile 
        115                 120                 125             


Phe Pro Gly Ala Leu Leu Lys Ala Asp Gln Ser Leu Leu Glu Asn Leu 
    130                 135                 140                 


Pro Thr Leu Ile Pro Val Asn Arg Gly Lys Thr Thr Ile Ser Val Asn 
145                 150                 155                 160 


Leu Pro Gly Leu Lys Asn Gly Glu Ser Asn Leu Thr Val Glu Asn Pro 
                165                 170                 175     


Ser Asn Ser Thr Val Arg Thr Ala Val Asn Asn Leu Val Glu Lys Trp 
            180                 185                 190         


Ile Gln Lys Tyr Ser Lys Thr His Ala Val Pro Ala Arg Met Gln Tyr 
        195                 200                 205             


Glu Ser Ile Ser Ala Gln Ser Met Ser Gln Leu Gln Ala Lys Phe Gly 
    210                 215                 220                 


Ala Asp Phe Ser Lys Val Gly Ala Pro Leu Asn Val Asp Phe Ser Ser 
225                 230                 235                 240 


Val His Lys Gly Glu Lys Gln Val Phe Ile Ala Asn Phe Arg Gln Val 
                245                 250                 255     


Tyr Tyr Thr Ala Ser Val Asp Ser Pro Asn Ser Pro Ser Ala Leu Phe 
            260                 265                 270         


Gly Ser Gly Ile Thr Pro Thr Asp Leu Ile Asn Arg Gly Val Asn Ser 
        275                 280                 285             


Lys Thr Pro Pro Val Tyr Val Ser Asn Val Ser Tyr Gly Arg Ala Met 
    290                 295                 300                 


Tyr Val Lys Phe Glu Thr Thr Ser Lys Ser Thr Lys Val Gln Ala Ala 
305                 310                 315                 320 


Ile Asp Ala Val Val Lys Gly Ala Lys Leu Lys Ala Gly Thr Glu Tyr 
                325                 330                 335     


Glu Asn Ile Leu Lys Asn Thr Lys Ile Thr Ala Val Val Leu Gly Gly 
            340                 345                 350         


Asn Pro Gly Glu Ala Ser Lys Val Ile Thr Gly Asn Ile Asp Thr Leu 
        355                 360                 365             


Lys Asp Leu Ile Gln Lys Gly Ser Asn Phe Ser Ala Gln Ser Pro Ala 
    370                 375                 380                 


Val Pro Ile Ser Tyr Thr Thr Ser Phe Val Lys Asp Asn Ser Ile Ala 
385                 390                 395                 400 


Thr Ile Gln Asn Asn Thr Asp Tyr Ile Glu Thr Lys Val Thr Ser Tyr 
                405                 410                 415     


Lys Asp Gly Ala Leu Thr Leu Asn His Asp Gly Ala Phe Val Ala Arg 
            420                 425                 430         


Phe Tyr Val Tyr Trp Glu Glu Leu Gly His Asp Ala Asp Gly Tyr Glu 
        435                 440                 445             


Thr Ile Arg Ser Arg Ser Trp Ser Gly Asn Gly Tyr Asn Arg Gly Ala 
    450                 455                 460                 


His Tyr Ser Thr Thr Leu Arg Phe Lys Gly Asn Val Arg Asn Ile Arg 
465                 470                 475                 480 


Val Lys Val Leu Gly Ala Thr Gly Leu Ala Trp Glu Pro Trp Arg Leu 
                485                 490                 495     


Ile Tyr Ser Lys Asn Asp Leu Pro Leu Val Pro Gln Arg Asn Ile Ser 
            500                 505                 510         


Thr Trp Gly Thr Thr Leu His Pro Gln Phe Glu Asp Lys Val Val Lys 
        515                 520                 525             


Asp Asn Thr Asp 
    530         


<210>  10
<211>  471
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  10

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asp Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  11
<211>  158
<212>  PRT
<213>  Anguilla anguilla

<400>  11

Val Ile Pro Glu Gly Tyr Thr Gln Glu Asn Val Ala Val Arg Gly Lys 
1               5                   10                  15      


Ala Thr Gln Ser Ala Gln Leu Arg Gly Glu His Ala Ala Asn Ser Glu 
            20                  25                  30          


Ala Ser Asn Ala Ile Asp Gly Asn Arg Asp Ser Asn Phe Tyr His Gly 
        35                  40                  45              


Ser Cys Thr His Ser Ser Gly Gln Ala Asn Pro Trp Trp Arg Val Asp 
    50                  55                  60                  


Leu Leu Gln Val Tyr Thr Ile Thr Ser Val Thr Ile Thr Asn Arg Gly 
65                  70                  75                  80  


Asp Cys Cys Gly Glu Arg Ile Ser Gly Ala Glu Ile Asn Ile Gly Gln 
                85                  90                  95      


His Leu Ala Ser Asn Gly Val Asn Asn Pro Glu Cys Ser Val Ile Gly 
            100                 105                 110         


Ser Met Ala Thr Gly Glu Thr Lys Thr Phe His Cys Pro Ala Pro Met 
        115                 120                 125             


Ile Gly Arg Tyr Val Val Thr Tyr Leu Pro Thr Ser Glu Ser Leu His 
    130                 135                 140                 


Leu Cys Glu Val Glu Val Asn Val Asp Lys Pro Ala Ala Ala 
145                 150                 155             


<210>  12
<211>  160
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  12

Glu Glu Asp Ile Asp Lys Ile Thr Glu Asp Lys Val Val Ser Thr Asn 
1               5                   10                  15      


Lys Val Ala Thr Gln Ser Ser Thr Asn Tyr Glu Gly Val Ala Ala Leu 
            20                  25                  30          


Ala Val Asp Gly Asn Lys Asp Gly Asp Tyr Gly His His Ser Val Thr 
        35                  40                  45              


His Thr Lys Ala Asp Ser Asn Ala Trp Trp Gln Val Asp Leu Gly Glu 
    50                  55                  60                  


Glu Phe Thr Val Ser Lys Val Asp Ile Tyr Asn Arg Thr Asp Ala Glu 
65                  70                  75                  80  


Pro Gln Arg Leu Ser Asn Phe Asp Val Ile Phe Leu Ser Ser Ser Gly 
                85                  90                  95      


Glu Glu Val Phe Arg Arg His Phe Asp Lys Val Ala Asp Gly Leu Leu 
            100                 105                 110         


Ser Leu Lys Val Pro Ser Val Gly Ala Lys Leu Val Lys Ile Glu Leu 
        115                 120                 125             


Lys Ser Ala Ala Ile Pro Leu Ser Leu Ala Glu Val Glu Val Tyr Gly 
    130                 135                 140                 


Ser Lys Arg Thr Pro Lys Lys Leu Ser Asn Ile Ala Leu Thr Lys Glu 
145                 150                 155                 160 


<210>  13
<211>  11
<212>  PRT
<213>  Streptococcus mitis

<400>  13

Glu Lys Thr Gly Leu Val Trp Glu Pro Trp Arg 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial

<400>  14

Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg 
1               5                   10      


<210>  15
<211>  11
<212>  PRT
<213>  Streptococcus intermedius

<400>  15

Gly Ala Thr Gly Leu Ala Trp Glu Pro Trp Arg 
1               5                   10      


<210>  16
<211>  46
<212>  PRT
<213>  Streptococcus mitis

<400>  16

His Ser Val Thr His Thr Asn Phe Glu Asp Asn Ala Trp Trp Gln Val 
1               5                   10                  15      


Asp Leu Gly Lys Thr Glu Asn Val Gly Lys Val Lys Leu Tyr Asn Arg 
            20                  25                  30          


Gly Asp Gly Asn Val Ala Asn Arg Leu Ser Asn Phe Asp Val 
        35                  40                  45      


<210>  17
<211>  56
<212>  PRT
<213>  Streptococcus mitis

<400>  17

Ser Asp Tyr Gly His His Ser Val Thr His Thr Asn Phe Glu Asp Asn 
1               5                   10                  15      


Ala Trp Trp Gln Val Asp Leu Gly Lys Thr Glu Asn Val Gly Lys Val 
            20                  25                  30          


Lys Leu Tyr Asn Arg Gly Asp Gly Asn Val Ala Asn Arg Leu Ser Asn 
        35                  40                  45              


Phe Asp Val Val Leu Leu Asn Glu 
    50                  55      


<210>  18
<211>  66
<212>  PRT
<213>  Streptococcus mitis

<400>  18

Asp Gly Asn Val Asp Ser Asp Tyr Gly His His Ser Val Thr His Thr 
1               5                   10                  15      


Asn Phe Glu Asp Asn Ala Trp Trp Gln Val Asp Leu Gly Lys Thr Glu 
            20                  25                  30          


Asn Val Gly Lys Val Lys Leu Tyr Asn Arg Gly Asp Gly Asn Val Ala 
        35                  40                  45              


Asn Arg Leu Ser Asn Phe Asp Val Val Leu Leu Asn Glu Ala Lys Gln 
    50                  55                  60                  


Glu Val 
65      


<210>  19
<211>  81
<212>  PRT
<213>  Streptococcus mitis

<400>  19

Ala Thr Arg Ala Val Asp Gly Asn Val Asp Ser Asp Tyr Gly His His 
1               5                   10                  15      


Ser Val Thr His Thr Asn Phe Glu Asp Asn Ala Trp Trp Gln Val Asp 
            20                  25                  30          


Leu Gly Lys Thr Glu Asn Val Gly Lys Val Lys Leu Tyr Asn Arg Gly 
        35                  40                  45              


Asp Gly Asn Val Ala Asn Arg Leu Ser Asn Phe Asp Val Val Leu Leu 
    50                  55                  60                  


Asn Glu Ala Lys Gln Glu Val Ala Arg Gln His Phe Asp Ser Leu Asn 
65                  70                  75                  80  


Gly 
    


<210>  20
<211>  96
<212>  PRT
<213>  Streptococcus mitis

<400>  20

Ala Tyr Gly Gly Ala Ala Thr Arg Ala Val Asp Gly Asn Val Asp Ser 
1               5                   10                  15      


Asp Tyr Gly His His Ser Val Thr His Thr Asn Phe Glu Asp Asn Ala 
            20                  25                  30          


Trp Trp Gln Val Asp Leu Gly Lys Thr Glu Asn Val Gly Lys Val Lys 
        35                  40                  45              


Leu Tyr Asn Arg Gly Asp Gly Asn Val Ala Asn Arg Leu Ser Asn Phe 
    50                  55                  60                  


Asp Val Val Leu Leu Asn Glu Ala Lys Gln Glu Val Ala Arg Gln His 
65                  70                  75                  80  


Phe Asp Ser Leu Asn Gly Lys Ala Glu Leu Glu Val Phe Phe Thr Ala 
                85                  90                  95      


<210>  21
<211>  111
<212>  PRT
<213>  Streptococcus mitis

<400>  21

Ser Gln Ser Ser Thr Ala Tyr Gly Gly Ala Ala Thr Arg Ala Val Asp 
1               5                   10                  15      


Gly Asn Val Asp Ser Asp Tyr Gly His His Ser Val Thr His Thr Asn 
            20                  25                  30          


Phe Glu Asp Asn Ala Trp Trp Gln Val Asp Leu Gly Lys Thr Glu Asn 
        35                  40                  45              


Val Gly Lys Val Lys Leu Tyr Asn Arg Gly Asp Gly Asn Val Ala Asn 
    50                  55                  60                  


Arg Leu Ser Asn Phe Asp Val Val Leu Leu Asn Glu Ala Lys Gln Glu 
65                  70                  75                  80  


Val Ala Arg Gln His Phe Asp Ser Leu Asn Gly Lys Ala Glu Leu Glu 
                85                  90                  95      


Val Phe Phe Thr Ala Lys Asp Ala Arg Tyr Val Lys Val Glu Leu 
            100                 105                 110     


<210>  22
<211>  126
<212>  PRT
<213>  Streptococcus mitis

<400>  22

Arg Gly Lys Gln Ala Ser Gln Ser Ser Thr Ala Tyr Gly Gly Ala Ala 
1               5                   10                  15      


Thr Arg Ala Val Asp Gly Asn Val Asp Ser Asp Tyr Gly His His Ser 
            20                  25                  30          


Val Thr His Thr Asn Phe Glu Asp Asn Ala Trp Trp Gln Val Asp Leu 
        35                  40                  45              


Gly Lys Thr Glu Asn Val Gly Lys Val Lys Leu Tyr Asn Arg Gly Asp 
    50                  55                  60                  


Gly Asn Val Ala Asn Arg Leu Ser Asn Phe Asp Val Val Leu Leu Asn 
65                  70                  75                  80  


Glu Ala Lys Gln Glu Val Ala Arg Gln His Phe Asp Ser Leu Asn Gly 
                85                  90                  95      


Lys Ala Glu Leu Glu Val Phe Phe Thr Ala Lys Asp Ala Arg Tyr Val 
            100                 105                 110         


Lys Val Glu Leu Lys Thr Lys Asn Thr Pro Leu Ser Leu Ala 
        115                 120                 125     


<210>  23
<211>  141
<212>  PRT
<213>  Streptococcus mitis

<400>  23

Thr Glu Asn Ile Ala Arg Gly Lys Gln Ala Ser Gln Ser Ser Thr Ala 
1               5                   10                  15      


Tyr Gly Gly Ala Ala Thr Arg Ala Val Asp Gly Asn Val Asp Ser Asp 
            20                  25                  30          


Tyr Gly His His Ser Val Thr His Thr Asn Phe Glu Asp Asn Ala Trp 
        35                  40                  45              


Trp Gln Val Asp Leu Gly Lys Thr Glu Asn Val Gly Lys Val Lys Leu 
    50                  55                  60                  


Tyr Asn Arg Gly Asp Gly Asn Val Ala Asn Arg Leu Ser Asn Phe Asp 
65                  70                  75                  80  


Val Val Leu Leu Asn Glu Ala Lys Gln Glu Val Ala Arg Gln His Phe 
                85                  90                  95      


Asp Ser Leu Asn Gly Lys Ala Glu Leu Glu Val Phe Phe Thr Ala Lys 
            100                 105                 110         


Asp Ala Arg Tyr Val Lys Val Glu Leu Lys Thr Lys Asn Thr Pro Leu 
        115                 120                 125             


Ser Leu Ala Glu Val Glu Val Phe Arg Ser Ala Thr Thr 
    130                 135                 140     


<210>  24
<211>  151
<212>  PRT
<213>  Streptococcus mitis

<400>  24

Asn Arg Pro Val Glu Thr Glu Asn Ile Ala Arg Gly Lys Gln Ala Ser 
1               5                   10                  15      


Gln Ser Ser Thr Ala Tyr Gly Gly Ala Ala Thr Arg Ala Val Asp Gly 
            20                  25                  30          


Asn Val Asp Ser Asp Tyr Gly His His Ser Val Thr His Thr Asn Phe 
        35                  40                  45              


Glu Asp Asn Ala Trp Trp Gln Val Asp Leu Gly Lys Thr Glu Asn Val 
    50                  55                  60                  


Gly Lys Val Lys Leu Tyr Asn Arg Gly Asp Gly Asn Val Ala Asn Arg 
65                  70                  75                  80  


Leu Ser Asn Phe Asp Val Val Leu Leu Asn Glu Ala Lys Gln Glu Val 
                85                  90                  95      


Ala Arg Gln His Phe Asp Ser Leu Asn Gly Lys Ala Glu Leu Glu Val 
            100                 105                 110         


Phe Phe Thr Ala Lys Asp Ala Arg Tyr Val Lys Val Glu Leu Lys Thr 
        115                 120                 125             


Lys Asn Thr Pro Leu Ser Leu Ala Glu Val Glu Val Phe Arg Ser Ala 
    130                 135                 140                 


Thr Thr Gln Val Gly Gln Asp 
145                 150     


<210>  25
<211>  158
<212>  PRT
<213>  Streptococcus mitis

<400>  25

Gln Gly Asn Arg Pro Val Glu Thr Glu Asn Ile Ala Arg Gly Lys Gln 
1               5                   10                  15      


Ala Ser Gln Ser Ser Thr Ala Tyr Gly Gly Ala Ala Thr Arg Ala Val 
            20                  25                  30          


Asp Gly Asn Val Asp Ser Asp Tyr Gly His His Ser Val Thr His Thr 
        35                  40                  45              


Asn Phe Glu Asp Asn Ala Trp Trp Gln Val Asp Leu Gly Lys Thr Glu 
    50                  55                  60                  


Asn Val Gly Lys Val Lys Leu Tyr Asn Arg Gly Asp Gly Asn Val Ala 
65                  70                  75                  80  


Asn Arg Leu Ser Asn Phe Asp Val Val Leu Leu Asn Glu Ala Lys Gln 
                85                  90                  95      


Glu Val Ala Arg Gln His Phe Asp Ser Leu Asn Gly Lys Ala Glu Leu 
            100                 105                 110         


Glu Val Phe Phe Thr Ala Lys Asp Ala Arg Tyr Val Lys Val Glu Leu 
        115                 120                 125             


Lys Thr Lys Asn Thr Pro Leu Ser Leu Ala Glu Val Glu Val Phe Arg 
    130                 135                 140                 


Ser Ala Thr Thr Gln Val Gly Gln Asp Arg Thr Ala Pro Val 
145                 150                 155             


