                         SEQUENCE LISTING

<110>  TRUBION PHARMACEUTICALS
       Ledbetter, et al.
 
<120>  BINDING PEPTIDES HAVING A C-TERMINALLY DISPOSED SPECIFIC BINDING 
       DOMAIN

<130>  30906/43032A

<150>  US 60/948,397
<151>  2007-07-06

<160>  549   

<170>  PatentIn version 3.5

<210>  1
<211>  2337
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-STD1-2e12HL (w/2E12 leader) (PN) CH2CH3

<400>  1
aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca     60

gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct    120

ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg    180

taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct    240

tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc    300

agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca    360

cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt    420

ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg    480

aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac    540

aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat    600

ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta    660

gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg    720

gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg    780

ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac    840

acatccccac cgagctcagc acctgaactc ctggggggac cgtcagtctt cctcttcccc    900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg   1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc   1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc   1140

aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga   1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc   1260

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat   1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1500

ccgggtaaga attatggtgg cggtggctcg ggcggtggtg gatctggagg aggtgggagt   1560

gggaattctc aggtgcagct gaaggagtca ggacctggcc tggtggcgcc ctcacagagc   1620

ctgtccatca catgcaccgt ctcagggttc tcattaaccg gctatggtgt aaactgggtt   1680

cgccagcctc caggaaaggg tctggagtgg ctgggaatga tatggggtga tggaagcaca   1740

gactataatt cagctctcaa atccagacta tcgatcacca aggacaactc caagagccaa   1800

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccagatacta ctgtgctcga   1860

gatggttata gtaactttca ttactatgtt atggactact ggggtcaagg aacctcagtc   1920

accgtctcct ctgggggtgg aggctctggt ggcggtggat ccggcggagg tgggtcgggt   1980

ggcggcggat ctgacattgt gctcacccaa tctccagctt ctttggctgt gtctctaggt   2040

cagagagcca ccatctcctg cagagccagt gaaagtgttg aatattatgt cacaagttta   2100

atgcagtggt accaacagaa accaggacag ccacccaaac tcctcatctc tgctgctagc   2160

aacgtagaat ctggggtccc tgccaggttt agtggcagtg ggtctgggac agactttagc   2220

ctcaacatcc atcctgtgga ggaggatgat attgcaatgt atttctgtca gcaaagtagg   2280

aaggttccat ggacgttcgg tggaggcacc aagctggaaa tcaaacgtta atctaga      2337


<210>  2
<211>  772
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-STD1-2e12HL (w/2E12 leader) (AA) CH2CH3

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(128)
<223>  VL

<220>
<221>  misc_feature
<222>  (129)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH

<220>
<221>  misc_feature
<222>  (268)..(281)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(519)
<223>  EFD-BD2 linker

<220>
<221>  misc_feature
<222>  (520)..(640)
<223>  VH2

<220>
<221>  misc_feature
<222>  (641)..(660)
<223>  Linker2

<400>  2

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Ser Ser Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro 
        515                 520                 525             


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 
    530                 535                 540                 


Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro 
545                 550                 555                 560 


Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr 
                565                 570                 575     


Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn 
            580                 585                 590         


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
        595                 600                 605             


Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr 
    610                 615                 620                 


Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            660                 665                 670         


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        675                 680                 685             


Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
    690                 695                 700                 


Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 
705                 710                 715                 720 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
                725                 730                 735     


Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys 
            740                 745                 750         


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        755                 760                 765             


Glu Ile Lys Arg 
    770         


<210>  3
<211>  772
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7sssIgG1(P238S/P331S)-STD1-2e12HL (w/2e12 leader) (AA) 

CH2CH3

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(128)
<223>  VL

<220>
<221>  misc_feature
<222>  (129)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH

<220>
<221>  misc_feature
<222>  (268)..(281)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(519)
<223>  EFD-BD2 linker

<220>
<221>  misc_feature
<222>  (520)..(640)
<223>  VH2

<220>
<221>  misc_feature
<222>  (641)..(660)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (661)..(772)
<223>  VL2

<400>  3

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Ser Ser Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro 
        515                 520                 525             


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 
    530                 535                 540                 


Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro 
545                 550                 555                 560 


Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr 
                565                 570                 575     


Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn 
            580                 585                 590         


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
        595                 600                 605             


Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr 
    610                 615                 620                 


Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            660                 665                 670         


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        675                 680                 685             


Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
    690                 695                 700                 


Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 
705                 710                 715                 720 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
                725                 730                 735     


Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys 
            740                 745                 750         


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        755                 760                 765             


Glu Ile Lys Arg 
    770         


<210>  4
<211>  2322
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-STD1-2e12LH (w/2e12 leader) (PN)

<400>  4
aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca     60

gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct    120

ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg    180

taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct    240

tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc    300

agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca    360

cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt    420

ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg    480

aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac    540

aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat    600

ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta    660

gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg    720

gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg    780

ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac    840

acatccccac cgagcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc    900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg   1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc   1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc   1140

aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga   1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc   1260

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat   1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1500

ccgggtaaga attatggtgg cggtggctcg ggcggtggtg gatctggagg aggtgggagt   1560

gggaattctg acattgtgct cacccaatct ccagcttctt tggctgtgtc tctaggtcag   1620

agagccacca tctcctgcag agccagtgaa agtgttgaat attatgtcac aagtttaatg   1680

cagtggtacc aacagaaacc aggacagcca cccaaactcc tcatctctgc tgctagcaac   1740

gtagaatctg gggtccctgc caggtttagt ggcagtgggt ctgggacaga ctttagcctc   1800

aacatccatc ctgtggagga ggatgatatt gcaatgtatt tctgtcagca aagtaggaag   1860

gttccatgga cgttcggtgg aggcaccaag ctggaaatca aacggggtgg cggtggatcc   1920

ggcggaggtg ggtcgggtgg cggcggatct caggtgcagc tgaaggagtc aggacctggc   1980

ctggtggcgc cctcacagag cctgtccatc acatgcaccg tctcagggtt ctcattaacc   2040

ggctatggtg taaactgggt tcgccagcct ccaggaaagg gtctggagtg gctgggaatg   2100

atatggggtg atggaagcac agactataat tcagctctca aatccagact atcgatcacc   2160

aaggacaact ccaagagcca agttttctta aaaatgaaca gtctgcaaac tgatgacaca   2220

gccagatact actgtgctcg agatggttat agtaactttc attactatgt tatggactac   2280

tggggtcaag gaacctcagt caccgtctcc tcttaatcta ga                      2322


<210>  5
<211>  767
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-STD1-2e12LH (w/2e12 leader) (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(128)
<223>  VL

<220>
<221>  misc_feature
<222>  (129)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH

<220>
<221>  misc_feature
<222>  (268)..(282)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(519)
<223>  EFD-BD2 linker

<220>
<221>  misc_feature
<222>  (520)..(631)
<223>  VL2

<220>
<221>  misc_feature
<222>  (632)..(646)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (647)..(767)
<223>  VH2

<400>  5

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Ser Ser Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Asn Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
        515                 520                 525             


Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
    530                 535                 540                 


Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln 
545                 550                 555                 560 


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn 
                565                 570                 575     


Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            580                 585                 590         


Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met 
        595                 600                 605             


Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly 
    610                 615                 620                 


Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 
                645                 650                 655     


Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
            660                 665                 670         


Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly 
        675                 680                 685             


Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp 
    690                 695                 700                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser 
705                 710                 715                 720 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                725                 730                 735     


Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr 
            740                 745                 750         


Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        755                 760                 765         


<210>  6
<211>  767
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7sssIgG1(P238S/P331S)-STD1-2e12LH (w/2e12 leader) (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(128)
<223>  VL

<220>
<221>  misc_feature
<222>  (129)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH

<220>
<221>  misc_feature
<222>  (268)..(282)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(519)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (520)..(631)
<223>  VL2

<220>
<221>  misc_feature
<222>  (632)..(646)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (647)..(767)
<223>  VH2

<400>  6

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Ser Ser Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Asn Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
        515                 520                 525             


Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
    530                 535                 540                 


Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln 
545                 550                 555                 560 


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn 
                565                 570                 575     


Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            580                 585                 590         


Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met 
        595                 600                 605             


Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly 
    610                 615                 620                 


Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 
                645                 650                 655     


Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
            660                 665                 670         


Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly 
        675                 680                 685             


Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp 
    690                 695                 700                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser 
705                 710                 715                 720 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                725                 730                 735     


Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr 
            740                 745                 750         


Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        755                 760                 765         


<210>  7
<211>  2376
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-STD2-2e12LH (w/2e12 leader) (PN)

<400>  7
aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca     60

gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct    120

ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg    180

taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct    240

tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc    300

agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca    360

cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt    420

ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg    480

aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac    540

aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat    600

ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta    660

gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg    720

gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg    780

ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac    840

acatccccac cgagcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc    900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg   1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc   1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc   1140

aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga   1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc   1260

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat   1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1500

ccgggtaaga attatggtgg cggtggctcg ggcggtggtg gatctggagg aggtgggagt   1560

gggaattatg gtggcggtgg ctcgggcggt ggtggatctg gaggaggtgg gagtgggaat   1620

tctgacattg tgctcaccca atctccagct tctttggctg tgtctctagg tcagagagcc   1680

accatctcct gcagagccag tgaaagtgtt gaatattatg tcacaagttt aatgcagtgg   1740

taccaacaga aaccaggaca gccacccaaa ctcctcatct ctgctgctag caacgtagaa   1800

tctggggtcc ctgccaggtt tagtggcagt gggtctggga cagactttag cctcaacatc   1860

catcctgtgg aggaggatga tattgcaatg tatttctgtc agcaaagtag gaaggttcca   1920

tggacgttcg gtggaggcac caagctggaa atcaaacggg gtggcggtgg atccggcgga   1980

ggtgggtcgg gtggcggcgg atctcaggtg cagctgaagg agtcaggacc tggcctggtg   2040

gcgccctcac agagcctgtc catcacatgc accgtctcag ggttctcatt aaccggctat   2100

ggtgtaaact gggttcgcca gcctccagga aagggtctgg agtggctggg aatgatatgg   2160

ggtgatggaa gcacagacta taattcagct ctcaaatcca gactatcgat caccaaggac   2220

aactccaaga gccaagtttt cttaaaaatg aacagtctgc aaactgatga cacagccaga   2280

tactactgtg ctcgagatgg ttatagtaac tttcattact atgttatgga ctactggggt   2340

caaggaacct cagtcaccgt ctcctcttaa tctaga                             2376


<210>  8
<211>  785
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-STD2-2e12LH (w/2e12 leader) (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(129)
<223>  VL

<220>
<221>  misc_feature
<222>  (130)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH

<220>
<221>  misc_feature
<222>  (268)..(282)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(537)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (538)..(649)
<223>  VL2

<220>
<221>  misc_feature
<222>  (650)..(664)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (665)..(795)
<223>  VH2

<400>  8

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Ser Ser Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Asn Ser Asp Ile Val Leu Thr Gln Ser 
    530                 535                 540                 


Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys 
545                 550                 555                 560 


Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp 
                565                 570                 575     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala 
            580                 585                 590         


Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        595                 600                 605             


Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile 
    610                 615                 620                 


Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly 
625                 630                 635                 640 


Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly 
                645                 650                 655     


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser Gly 
            660                 665                 670         


Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val 
        675                 680                 685             


Ser Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro 
    690                 695                 700                 


Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser 
705                 710                 715                 720 


Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp 
                725                 730                 735     


Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp 
            740                 745                 750         


Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His 
        755                 760                 765             


Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
    770                 775                 780                 


Ser 
785 


<210>  9
<211>  785
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7sssIgG1(P238S/P331S)-STD2-2e12LH (w/2e12 leader) (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(128)
<223>  VL

<220>
<221>  misc_feature
<222>  (129)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH

<220>
<221>  misc_feature
<222>  (268)..(281)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(537)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (538)..(649)
<223>  VL2

<220>
<221>  misc_feature
<222>  (650)..(664)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (665)..(785)
<223>  VH2

<400>  9

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Ser Ser Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Asn Ser Asp Ile Val Leu Thr Gln Ser 
    530                 535                 540                 


Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys 
545                 550                 555                 560 


Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp 
                565                 570                 575     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala 
            580                 585                 590         


Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        595                 600                 605             


Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile 
    610                 615                 620                 


Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly 
625                 630                 635                 640 


Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly 
                645                 650                 655     


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser Gly 
            660                 665                 670         


Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val 
        675                 680                 685             


Ser Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro 
    690                 695                 700                 


Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser 
705                 710                 715                 720 


Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp 
                725                 730                 735     


Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp 
            740                 745                 750         


Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His 
        755                 760                 765             


Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
    770                 775                 780                 


Ser 
785 


<210>  10
<211>  2391
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-STD2-2e12HL (w/2e12 leader) (PN)

<400>  10
aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca     60

gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct    120

ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg    180

taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct    240

tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc    300

agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca    360

cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt    420

ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg    480

aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac    540

aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat    600

ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta    660

gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg    720

gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg    780

ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac    840

acatccccac cgagcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc    900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg   1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc   1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc   1140

aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga   1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc   1260

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat   1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1500

ccgggtaaga attatggtgg cggtggctcg ggcggtggtg gatctggagg aggtgggagt   1560

gggaattatg gtggcggtgg ctcgggcggt ggtggatctg gaggaggtgg gagtgggaat   1620

tctcaggtgc agctgaagga gtcaggacct ggcctggtgg cgccctcaca gagcctgtcc   1680

atcacatgca ccgtctcagg gttctcatta accggctatg gtgtaaactg ggttcgccag   1740

cctccaggaa agggtctgga gtggctggga atgatatggg gtgatggaag cacagactat   1800

aattcagctc tcaaatccag actatcgatc accaaggaca actccaagag ccaagttttc   1860

ttaaaaatga acagtctgca aactgatgac acagccagat actactgtgc tcgagatggt   1920

tatagtaact ttcattacta tgttatggac tactggggtc aaggaacctc agtcaccgtc   1980

tcctctgggg gtggaggctc tggtggcggt ggatccggcg gaggtgggtc gggtggcggc   2040

ggatctgaca ttgtgctcac ccaatctcca gcttctttgg ctgtgtctct aggtcagaga   2100

gccaccatct cctgcagagc cagtgaaagt gttgaatatt atgtcacaag tttaatgcag   2160

tggtaccaac agaaaccagg acagccaccc aaactcctca tctctgctgc tagcaacgta   2220

gaatctgggg tccctgccag gtttagtggc agtgggtctg ggacagactt tagcctcaac   2280

atccatcctg tggaggagga tgatattgca atgtatttct gtcagcaaag taggaaggtt   2340

ccatggacgt tcggtggagg caccaagctg gaaatcaaac gttaatctag a            2391


<210>  11
<211>  790
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-STD2-2e12HL (w/2e12 leader) (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(128)
<223>  VL

<220>
<221>  misc_feature
<222>  (129)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH

<220>
<221>  misc_feature
<222>  (268)..(282)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(537)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (538)..(658)
<223>  VH2

<220>
<221>  misc_feature
<222>  (659)..(678)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (679)..(790)
<223>  VL2

<400>  11

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Ser Ser Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Asn Ser Gln Val Gln Leu Lys Glu Ser 
    530                 535                 540                 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr 
545                 550                 555                 560 


Val Ser Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln 
                565                 570                 575     


Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly 
            580                 585                 590         


Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys 
        595                 600                 605             


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
    610                 615                 620                 


Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe 
625                 630                 635                 640 


His Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
                645                 650                 655     


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser 
        675                 680                 685             


Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
    690                 695                 700                 


Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln 
705                 710                 715                 720 


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val 
                725                 730                 735     


Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
            740                 745                 750         


Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr 
        755                 760                 765             


Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr 
    770                 775                 780                 


Lys Leu Glu Ile Lys Arg 
785                 790 


<210>  12
<211>  790
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7sssIgG1(P238S/P331S)-STD2-2e12HL (w/2e12 leader) (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(128)
<223>  VL

<220>
<221>  misc_feature
<222>  (129)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH

<220>
<221>  misc_feature
<222>  (268)..(282)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(537)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (538)..(658)
<223>  VH2

<220>
<221>  misc_feature
<222>  (659)..(678)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (679)..(790)
<223>  VL2

<400>  12

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Ser Ser Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Asn Ser Gln Val Gln Leu Lys Glu Ser 
    530                 535                 540                 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr 
545                 550                 555                 560 


Val Ser Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln 
                565                 570                 575     


Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly 
            580                 585                 590         


Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys 
        595                 600                 605             


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
    610                 615                 620                 


Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe 
625                 630                 635                 640 


His Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
                645                 650                 655     


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser 
        675                 680                 685             


Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
    690                 695                 700                 


Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln 
705                 710                 715                 720 


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val 
                725                 730                 735     


Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
            740                 745                 750         


Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr 
        755                 760                 765             


Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr 
    770                 775                 780                 


Lys Leu Glu Ile Lys Arg 
785                 790 


<210>  13
<211>  2283
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-H1-2e12HL (w/2e12 leader) (PN)

<400>  13
aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca     60

gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct    120

ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg    180

taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct    240

tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc    300

agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca    360

cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt    420

ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg    480

aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac    540

aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat    600

ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta    660

gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg    720

gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg    780

ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac    840

acatccccac cgagcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc    900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg   1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc   1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc   1140

aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga   1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc   1260

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat   1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1500

ccgggtaaga attctcaggt gcagctgaag gagtcaggac ctggcctggt ggcgccctca   1560

cagagcctgt ccatcacatg caccgtctca gggttctcat taaccggcta tggtgtaaac   1620

tgggttcgcc agcctccagg aaagggtctg gagtggctgg gaatgatatg gggtgatgga   1680

agcacagact ataattcagc tctcaaatcc agactatcga tcaccaagga caactccaag   1740

agccaagttt tcttaaaaat gaacagtctg caaactgatg acacagccag atactactgt   1800

gctcgagatg gttatagtaa ctttcattac tatgttatgg actactgggg tcaaggaacc   1860

tcagtcaccg tctcctctgg gggtggaggc tctggtggcg gtggatccgg cggaggtggg   1920

tcgggtggcg gcggatctga cattgtgctc acccaatctc cagcttcttt ggctgtgtct   1980

ctaggtcaga gagccaccat ctcctgcaga gccagtgaaa gtgttgaata ttatgtcaca   2040

agtttaatgc agtggtacca acagaaacca ggacagccac ccaaactcct catctctgct   2100

gctagcaacg tagaatctgg ggtccctgcc aggtttagtg gcagtgggtc tgggacagac   2160

tttagcctca acatccatcc tgtggaggag gatgatattg caatgtattt ctgtcagcaa   2220

agtaggaagg ttccatggac gttcggtgga ggcaccaagc tggaaatcaa acgttaatct   2280

aga                                                                 2283


<210>  14
<211>  754
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-H1-2e12HL (w/2e12 leader) (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(128)
<223>  VL

<220>
<221>  misc_feature
<222>  (129)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH

<220>
<221>  misc_feature
<222>  (268)..(281)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(501)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (502)..(622)
<223>  VH2

<220>
<221>  misc_feature
<222>  (623)..(642)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (643)..(754)
<223>  VL2

<400>  14

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu 
            500                 505                 510         


Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe 
        515                 520                 525             


Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys 
    530                 535                 540                 


Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr 
545                 550                 555                 560 


Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys 
                565                 570                 575     


Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
            580                 585                 590         


Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val 
        595                 600                 605             


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 
                645                 650                 655     


Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu 
            660                 665                 670         


Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln 
        675                 680                 685             


Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val 
    690                 695                 700                 


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn 
705                 710                 715                 720 


Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln 
                725                 730                 735     


Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            740                 745                 750         


Lys Arg 
        


<210>  15
<211>  2301
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-H2-2e12HL (w/2e12 leader) (PN)

<400>  15
aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca     60

gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct    120

ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg    180

taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct    240

tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc    300

agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca    360

cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt    420

ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg    480

aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac    540

aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat    600

ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta    660

gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg    720

gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg    780

ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac    840

acatccccac cgagcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc    900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg   1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc   1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc   1140

aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga   1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc   1260

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat   1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1500

ccgggtaagg gtggcggtgg ctcggggaat tctcaggtgc agctgaagga gtcaggacct   1560

ggcctggtgg cgccctcaca gagcctgtcc atcacatgca ccgtctcagg gttctcatta   1620

accggctatg gtgtaaactg ggttcgccag cctccaggaa agggtctgga gtggctggga   1680

atgatatggg gtgatggaag cacagactat aattcagctc tcaaatccag actatcgatc   1740

accaaggaca actccaagag ccaagttttc ttaaaaatga acagtctgca aactgatgac   1800

acagccagat actactgtgc tcgagatggt tatagtaact ttcattacta tgttatggac   1860

tactggggtc aaggaacctc agtcaccgtc tcctctgggg gtggaggctc tggtggcggt   1920

ggatccggcg gaggtgggtc gggtggcggc ggatctgaca ttgtgctcac ccaatctcca   1980

gcttctttgg ctgtgtctct aggtcagaga gccaccatct cctgcagagc cagtgaaagt   2040

gttgaatatt atgtcacaag tttaatgcag tggtaccaac agaaaccagg acagccaccc   2100

aaactcctca tctctgctgc tagcaacgta gaatctgggg tccctgccag gtttagtggc   2160

agtgggtctg ggacagactt tagcctcaac atccatcctg tggaggagga tgatattgca   2220

atgtatttct gtcagcaaag taggaaggtt ccatggacgt tcggtggagg caccaagctg   2280

gaaatcaaac gttaatctag a                                             2301


<210>  16
<211>  760
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-H2-2e12HL (w/2e12 leader) (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(127)
<223>  VL

<220>
<221>  misc_feature
<222>  (128)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH

<220>
<221>  misc_feature
<222>  (268)..(282)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(507)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (629)..(648)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (649)..(760)
<223>  VL2

<400>  16

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Gly Gly Gly Gly Ser Gly Asn Ser Gln Val Gln Leu Lys 
            500                 505                 510         


Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr 
        515                 520                 525             


Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val 
    530                 535                 540                 


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly 
545                 550                 555                 560 


Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile 
                565                 570                 575     


Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu 
            580                 585                 590         


Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser 
        595                 600                 605             


Asn Phe His Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
    610                 615                 620                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
625                 630                 635                 640 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
                645                 650                 655     


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 
            660                 665                 670         


Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr 
        675                 680                 685             


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser 
    690                 695                 700                 


Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
705                 710                 715                 720 


Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala 
                725                 730                 735     


Met Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly 
            740                 745                 750         


Gly Thr Lys Leu Glu Ile Lys Arg 
        755                 760 


<210>  17
<211>  2307
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-H3-2e12HL (w/e12 leader) (PN)

<400>  17
aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca     60

gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct    120

ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg    180

taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct    240

tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc    300

agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca    360

cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt    420

ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg    480

aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac    540

aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat    600

ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta    660

gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg    720

gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg    780

ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac    840

acatccccac cgagcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc    900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg   1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc   1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc   1140

aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga   1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc   1260

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat   1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1500

ccgggtaaga attatggtgg cggtggctct gggaattctc aggtgcagct gaaggagtca   1560

ggacctggcc tggtggcgcc ctcacagagc ctgtccatca catgcaccgt ctcagggttc   1620

tcattaaccg gctatggtgt aaactgggtt cgccagcctc caggaaaggg tctggagtgg   1680

ctgggaatga tatggggtga tggaagcaca gactataatt cagctctcaa atccagacta   1740

tcgatcacca aggacaactc caagagccaa gttttcttaa aaatgaacag tctgcaaact   1800

gatgacacag ccagatacta ctgtgctcga gatggttata gtaactttca ttactatgtt   1860

atggactact ggggtcaagg aacctcagtc accgtctcct ctgggggtgg aggctctggt   1920

ggcggtggat ccggcggagg tgggtcgggt ggcggcggat ctgacattgt gctcacccaa   1980

tctccagctt ctttggctgt gtctctaggt cagagagcca ccatctcctg cagagccagt   2040

gaaagtgttg aatattatgt cacaagttta atgcagtggt accaacagaa accaggacag   2100

ccacccaaac tcctcatctc tgctgctagc aacgtagaat ctggggtccc tgccaggttt   2160

agtggcagtg ggtctgggac agactttagc ctcaacatcc atcctgtgga ggaggatgat   2220

attgcaatgt atttctgtca gcaaagtagg aaggttccat ggacgttcgg tggaggcacc   2280

aagctggaaa tcaaacgtta atctaga                                       2307


<210>  18
<211>  762
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-H3-2e12HL (w/e12 leader) (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(128)
<223>  VL

<220>
<221>  misc_feature
<222>  (129)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH

<220>
<221>  misc_feature
<222>  (268)..(282)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(509)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (510)..(630)
<223>  VH2

<220>
<221>  misc_feature
<222>  (631)..(650)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (651)..(762)
<223>  VL2

<400>  18

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly Asn Ser Gln Val Gln 
            500                 505                 510         


Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
        515                 520                 525             


Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn 
    530                 535                 540                 


Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile 
545                 550                 555                 560 


Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
                565                 570                 575     


Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
            580                 585                 590         


Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly 
        595                 600                 605             


Tyr Ser Asn Phe His Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr 
    610                 615                 620                 


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
                645                 650                 655     


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
            660                 665                 670         


Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln 
        675                 680                 685             


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala 
    690                 695                 700                 


Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
705                 710                 715                 720 


Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp 
                725                 730                 735     


Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe 
            740                 745                 750         


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        755                 760         


<210>  19
<211>  2316
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-H4-2e12HL (PN)

<400>  19
aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca     60

gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct    120

ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg    180

taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct    240

tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc    300

agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca    360

cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt    420

ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg    480

aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac    540

aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat    600

ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta    660

gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg    720

gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg    780

ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac    840

acatccccac cgagcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc    900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg   1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc   1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc   1140

aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga   1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc   1260

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat   1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1500

ccgggtaagg gtggcggtgg ctcgggcggt ggtggatctg ggaattctca ggtgcagctg   1560

aaggagtcag gacctggcct ggtggcgccc tcacagagcc tgtccatcac atgcaccgtc   1620

tcagggttct cattaaccgg ctatggtgta aactgggttc gccagcctcc aggaaagggt   1680

ctggagtggc tgggaatgat atggggtgat ggaagcacag actataattc agctctcaaa   1740

tccagactat cgatcaccaa ggacaactcc aagagccaag ttttcttaaa aatgaacagt   1800

ctgcaaactg atgacacagc cagatactac tgtgctcgag atggttatag taactttcat   1860

tactatgtta tggactactg gggtcaagga acctcagtca ccgtctcctc tgggggtgga   1920

ggctctggtg gcggtggatc cggcggaggt gggtcgggtg gcggcggatc tgacattgtg   1980

ctcacccaat ctccagcttc tttggctgtg tctctaggtc agagagccac catctcctgc   2040

agagccagtg aaagtgttga atattatgtc acaagtttaa tgcagtggta ccaacagaaa   2100

ccaggacagc cacccaaact cctcatctct gctgctagca acgtagaatc tggggtccct   2160

gccaggttta gtggcagtgg gtctgggaca gactttagcc tcaacatcca tcctgtggag   2220

gaggatgata ttgcaatgta tttctgtcag caaagtagga aggttccatg gacgttcggt   2280

ggaggcacca agctggaaat caaacgttaa tctaga                             2316


<210>  20
<211>  765
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-H4-2e12HL (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(128)
<223>  VL

<220>
<221>  misc_feature
<222>  (129)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH

<220>
<221>  misc_feature
<222>  (268)..(282)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(512)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (513)..(633)
<223>  VH2

<220>
<221>  misc_feature
<222>  (634)..(653)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (654)..(765)
<223>  VL2

<400>  20

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
            500                 505                 510         


Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
        515                 520                 525             


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
    530                 535                 540                 


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
545                 550                 555                 560 


Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
                565                 570                 575     


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
            580                 585                 590         


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
        595                 600                 605             


Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met Asp Tyr Trp Gly 
    610                 615                 620                 


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
625                 630                 635                 640 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
                645                 650                 655     


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
            660                 665                 670         


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser 
        675                 680                 685             


Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
    690                 695                 700                 


Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser 
705                 710                 715                 720 


Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu 
                725                 730                 735     


Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro 
            740                 745                 750         


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        755                 760                 765 


<210>  21
<211>  2322
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-H5-2e12HL (w/2e12 leader) (PN)

<400>  21
aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca     60

gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct    120

ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg    180

taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct    240

tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc    300

agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca    360

cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt    420

ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg    480

aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac    540

aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat    600

ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta    660

gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg    720

gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg    780

ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac    840

acatccccac cgagcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc    900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg   1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc   1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc   1140

aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga   1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc   1260

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat   1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1500

ccgggtaaga attatggtgg cggtggctcg ggcggtggtg gatctgggaa ttctcaggtg   1560

cagctgaagg agtcaggacc tggcctggtg gcgccctcac agagcctgtc catcacatgc   1620

accgtctcag ggttctcatt aaccggctat ggtgtaaact gggttcgcca gcctccagga   1680

aagggtctgg agtggctggg aatgatatgg ggtgatggaa gcacagacta taattcagct   1740

ctcaaatcca gactatcgat caccaaggac aactccaaga gccaagtttt cttaaaaatg   1800

aacagtctgc aaactgatga cacagccaga tactactgtg ctcgagatgg ttatagtaac   1860

tttcattact atgttatgga ctactggggt caaggaacct cagtcaccgt ctcctctggg   1920

ggtggaggct ctggtggcgg tggatccggc ggaggtgggt cgggtggcgg cggatctgac   1980

attgtgctca cccaatctcc agcttctttg gctgtgtctc taggtcagag agccaccatc   2040

tcctgcagag ccagtgaaag tgttgaatat tatgtcacaa gtttaatgca gtggtaccaa   2100

cagaaaccag gacagccacc caaactcctc atctctgctg ctagcaacgt agaatctggg   2160

gtccctgcca ggtttagtgg cagtgggtct gggacagact ttagcctcaa catccatcct   2220

gtggaggagg atgatattgc aatgtatttc tgtcagcaaa gtaggaaggt tccatggacg   2280

ttcggtggag gcaccaagct ggaaatcaaa cgttaatcta ga                      2322


<210>  22
<211>  767
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-H5-2e12HL (w/2e12 leader) (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(128)
<223>  VL

<220>
<221>  misc_feature
<222>  (129)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH

<220>
<221>  misc_feature
<222>  (268)..(282)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(514)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (515)..(635)
<223>  VH2

<220>
<221>  misc_feature
<222>  (636)..(655)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (656)..(767)
<223>  VL2

<400>  22

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro 
        515                 520                 525             


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
    530                 535                 540                 


Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
545                 550                 555                 560 


Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala 
                565                 570                 575     


Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val 
            580                 585                 590         


Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr 
        595                 600                 605             


Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met Asp Tyr 
    610                 615                 620                 


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                645                 650                 655     


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
            660                 665                 670         


Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val 
        675                 680                 685             


Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
    690                 695                 700                 


Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg 
705                 710                 715                 720 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro 
                725                 730                 735     


Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys 
            740                 745                 750         


Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        755                 760                 765         


<210>  23
<211>  2331
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-H6-2e12HL (w/2e12 leader) (PN)

<400>  23
aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca     60

gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct    120

ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg    180

taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct    240

tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc    300

agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca    360

cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt    420

ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg    480

aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac    540

aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat    600

ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta    660

gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg    720

gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg    780

ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac    840

acatccccac cgagcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc    900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg   1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc   1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc   1140

aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga   1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc   1260

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat   1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1500

ccgggtaagg gtggcggtgg ctcgggcggt ggtggatctg ggggaggagg cagcgggaat   1560

tctcaggtgc agctgaagga gtcaggacct ggcctggtgg cgccctcaca gagcctgtcc   1620

atcacatgca ccgtctcagg gttctcatta accggctatg gtgtaaactg ggttcgccag   1680

cctccaggaa agggtctgga gtggctggga atgatatggg gtgatggaag cacagactat   1740

aattcagctc tcaaatccag actatcgatc accaaggaca actccaagag ccaagttttc   1800

ttaaaaatga acagtctgca aactgatgac acagccagat actactgtgc tcgagatggt   1860

tatagtaact ttcattacta tgttatggac tactggggtc aaggaacctc agtcaccgtc   1920

tcctctgggg gtggaggctc tggtggcggt ggatccggcg gaggtgggtc gggtggcggc   1980

ggatctgaca ttgtgctcac ccaatctcca gcttctttgg ctgtgtctct aggtcagaga   2040

gccaccatct cctgcagagc cagtgaaagt gttgaatatt atgtcacaag tttaatgcag   2100

tggtaccaac agaaaccagg acagccaccc aaactcctca tctctgctgc tagcaacgta   2160

gaatctgggg tccctgccag gtttagtggc agtgggtctg ggacagactt tagcctcaac   2220

atccatcctg tggaggagga tgatattgca atgtatttct gtcagcaaag taggaaggtt   2280

ccatggacgt tcggtggagg caccaagctg gaaatcaaac gttaatctag a            2331


<210>  24
<211>  770
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-H6-2e12HL (w/2e12 leader) (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(128)
<223>  VL

<220>
<221>  misc_feature
<222>  (129)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH

<220>
<221>  misc_feature
<222>  (268)..(282)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(517)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (518)..(638)
<223>  VH2

<220>
<221>  misc_feature
<222>  (639)..(658)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (659)..(770)
<223>  VL2

<400>  24

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            500                 505                 510         


Gly Ser Gly Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu 
        515                 520                 525             


Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe 
    530                 535                 540                 


Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys 
545                 550                 555                 560 


Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr 
                565                 570                 575     


Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys 
            580                 585                 590         


Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
        595                 600                 605             


Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val 
    610                 615                 620                 


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly 
625                 630                 635                 640 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                645                 650                 655     


Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 
            660                 665                 670         


Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu 
        675                 680                 685             


Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln 
    690                 695                 700                 


Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val 
705                 710                 715                 720 


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn 
                725                 730                 735     


Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln 
            740                 745                 750         


Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        755                 760                 765             


Lys Arg 
    770 


<210>  25
<211>  2301
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  2H7sscIgG1-H7-2e12HL (w/2e12 linker ) (PN)

<400>  25
aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca     60

gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct    120

ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg    180

taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct    240

tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc    300

agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca    360

cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt    420

ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg    480

aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac    540

aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat    600

ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta    660

gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg    720

gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg    780

ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac    840

acatccccac cgtgcccagc acctgaactc ctggggggat cgtcagtctt cctcttcccc    900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg   1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc   1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc   1140

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga   1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc   1260

ctgacctgcc tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat   1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1500

ccgggtaagg ggtgtccacc ttgtccgaat tctcaggtgc agctgaagga gtcagggcct   1560

ggcagcgtgg cgccctcaca gagcctgtcc atcacatgca ccgtctcagg gttctcatta   1620

accggctatg gtgtaaactg ggttcgccag cctccaggaa agggtctgga gtggctggga   1680

atgatatggg gtgatggaag cacagactat aattcagctc tcaaatccag actatcgatc   1740

accaaggaca actccaagag ccaagttttc ttaaaaatga acagtctgca aactgatgac   1800

acagccagat actactgtgc tcgagatggt tatagtaact ttcattacta tgttatggac   1860

tactggggtc aaggaacctc agtcaccgtc tcctctgggg gtggaggctc tggtggcggt   1920

ggatccggcg gaggtgggtc gggtggcggc ggatctgaca ttgtgctcac ccaatctcca   1980

gcttctttgg ctgtgtctct aggtcagaga gccaccatct cctgcagagc cagtgaaagt   2040

gttgaatatt atgtcacaag tttaatgcag tggtaccaac agaaaccagg acagccaccc   2100

aagctcctca tctctgctgc tagcaacgta gaatctgggg tccctgccag gtttagtggc   2160

agtgggtctg ggacagactt tagcctcaac atccatcctg tggaggagga tgatattgca   2220

atgtatttct gtcagcaaag taggaaggtt ccatggacgt tcggtggagg caccaagctg   2280

gaaatcaaac gttaatctag a                                             2301


<210>  26
<211>  760
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7sscIgG1-H7-2e12HL (w/2e12 linker ) (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(128)
<223>  VL

<220>
<221>  misc_feature
<222>  (129)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH

<220>
<221>  misc_feature
<222>  (268)..(282)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(507)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (508)..(628)
<223>  VH2

<220>
<221>  misc_feature
<222>  (629)..(648)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (649)..(760)
<223>  VL2

<400>  26

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Gly Cys Pro Pro Cys Pro Asn Ser Gln Val Gln Leu Lys 
            500                 505                 510         


Glu Ser Gly Pro Gly Ser Val Ala Pro Ser Gln Ser Leu Ser Ile Thr 
        515                 520                 525             


Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val 
    530                 535                 540                 


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly 
545                 550                 555                 560 


Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile 
                565                 570                 575     


Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu 
            580                 585                 590         


Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser 
        595                 600                 605             


Asn Phe His Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
    610                 615                 620                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
625                 630                 635                 640 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
                645                 650                 655     


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 
            660                 665                 670         


Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr 
        675                 680                 685             


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser 
    690                 695                 700                 


Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
705                 710                 715                 720 


Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala 
                725                 730                 735     


Met Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly 
            740                 745                 750         


Gly Thr Lys Leu Glu Ile Lys Arg 
        755                 760 


<210>  27
<211>  2283
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-H7-G194 HL (w/2e12 leader) (PN)

<400>  27
aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca     60

gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct    120

ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg    180

taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct    240

tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc    300

agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca    360

cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt    420

ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg    480

aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac    540

aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat    600

ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta    660

gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg    720

gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg    780

ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac    840

acatccccac cgtgcccagc acctgaactc ctggggggat cgtcagtctt cctcttcccc    900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg   1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc   1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc   1140

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga   1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc   1260

ctgacctgcc tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat   1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1500

ccgggtaagg ggtgtccacc ttgtccgaat tctgaggtcc agctgcaaca gtctggacct   1560

gaactggtga agcctggagc ttcaatgaag atttcctgca aggcctctgg ttactcattc   1620

actggctaca tcgtgaactg gctgaagcag agccatggaa agaaccttga gtggattgga   1680

cttattaatc catacaaagg tcttactacc tacaaccaga aattcaaggg caaggccaca   1740

ttaactgtag acaagtcatc cagcacagcc tacatggagc tcctcagtct gacatctgaa   1800

gactctgcag tctattactg tgcaagatct gggtactatg gtgactcgga ctggtacttc   1860

gatgtctggg gcgcagggac cacggtcacc gtctcctctg gtggcggtgg ctcgggcggt   1920

ggtggatctg gaggaggtgg gagcgctagc gacatccaga tgacacagac tacatcctcc   1980

ctgtctgcct ctctgggaga cagagtcacc atcagttgca gggcaagtca ggacattcgc   2040

aattatttaa actggtatca gcagaaacca gatggaactg ttaaactcct gatctactac   2100

acatcaagat tacactcagg agtcccatca aggttcagtg gcagtgggtc tggaacagat   2160

tattctctca ccattgccaa cctgcaacca gaagatattg ccacttactt ttgccaacag   2220

ggtaatacgc ttccgtggac gttcggtgga ggcaccaaac tggtaaccaa acggtaatct   2280

aga                                                                 2283


<210>  28
<211>  754
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-H7-G194 HL (w/2e12 leader) (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(128)
<223>  VL

<220>
<221>  misc_feature
<222>  (129)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH1

<220>
<221>  misc_feature
<222>  (268)..(282)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(507)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (508)..(629)
<223>  VH2

<220>
<221>  misc_feature
<222>  (630)..(646)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (647)..(754)
<223>  VL2

<400>  28

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Gly Cys Pro Pro Cys Pro Asn Ser Glu Val Gln Leu Gln 
            500                 505                 510         


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser 
        515                 520                 525             


Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Ile Val Asn Trp Leu 
    530                 535                 540                 


Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile Gly Leu Ile Asn Pro 
545                 550                 555                 560 


Tyr Lys Gly Leu Thr Thr Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                565                 570                 575     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser 
            580                 585                 590         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr 
        595                 600                 605             


Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr 
    610                 615                 620                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Ala Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
                645                 650                 655     


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
            660                 665                 670         


Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
        675                 680                 685             


Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val 
    690                 695                 700                 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
705                 710                 715                 720 


Ile Ala Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
                725                 730                 735     


Gly Asn Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Val Thr 
            740                 745                 750         


Lys Arg 
        


<210>  29
<211>  2298
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-H7-G281 HL (w/2e12 leader) (PN)

<400>  29
aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca     60

gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct    120

ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg    180

taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct    240

tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc    300

agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca    360

cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt    420

ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg    480

aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac    540

aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat    600

ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta    660

gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg    720

gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg    780

ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac    840

acatccccac cgtgcccagc acctgaactc ctggggggat cgtcagtctt cctcttcccc    900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg   1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc   1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc   1140

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga   1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc   1260

ctgacctgcc tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat   1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1500

ccgggtaagg ggtgtccacc ttgtccgaat tctgaggtcc agctgcaaca gtctggacct   1560

gaactggtga agcctggagc ttcaatgaag atttcctgca aggcctctgg ttactcattc   1620

actggctaca tcgtgaactg gctgaagcag agccatggaa agaaccttga gtggattgga   1680

cttattaatc catacaaagg tcttactacc tacaaccaga aattcaaggg caaggccaca   1740

ttaactgtag acaagtcatc cagcacagcc tacatggagc tcctcagtct gacatctgaa   1800

gactctgcag tctattactg tgcaagatct gggtactatg gtgactcgga ctggtacttc   1860

gatgtctggg gcgcagggac cacggtcacc gtctcctctg gtggcggtgg ctcgggcggt   1920

ggtggatctg gaggaggtgg gagcggggga ggtggcagtg ctagcgacat ccagatgaca   1980

cagactacat cctccctgtc tgcctctctg ggagacagag tcaccatcag ttgcagggca   2040

agtcaggaca ttcgcaatta tttaaactgg tatcagcaga aaccagatgg aactgttaaa   2100

ctcctgatct actacacatc aagattacac tcaggagtcc catcaaggtt cagtggcagt   2160

gggtctggaa cagattattc tctcaccatt gccaacctgc aaccagaaga tattgccact   2220

tacttttgcc aacagggtaa tacgcttccg tggacgttcg gtggaggcac caaactggta   2280

accaaacggt aatctaga                                                 2298


<210>  30
<211>  759
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7sssIgG1-H7-G281 HL (w/2e12 leader) (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(128)
<223>  VL1

<220>
<221>  misc_feature
<222>  (129)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH1

<220>
<221>  misc_feature
<222>  (268)..(282)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(507)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (508)..(629)
<223>  VH2

<220>
<221>  misc_feature
<222>  (630)..(651)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (652)..(759)
<223>  VL2

<400>  30

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Gly Cys Pro Pro Cys Pro Asn Ser Glu Val Gln Leu Gln 
            500                 505                 510         


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser 
        515                 520                 525             


Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Ile Val Asn Trp Leu 
    530                 535                 540                 


Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile Gly Leu Ile Asn Pro 
545                 550                 555                 560 


Tyr Lys Gly Leu Thr Thr Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                565                 570                 575     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser 
            580                 585                 590         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr 
        595                 600                 605             


Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr 
    610                 615                 620                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Asp Ile Gln Met Thr 
                645                 650                 655     


Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile 
            660                 665                 670         


Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln 
        675                 680                 685             


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg 
    690                 695                 700                 


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
705                 710                 715                 720 


Asp Tyr Ser Leu Thr Ile Ala Asn Leu Gln Pro Glu Asp Ile Ala Thr 
                725                 730                 735     


Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gly Gly 
            740                 745                 750         


Thr Lys Leu Val Thr Lys Arg 
        755                 


<210>  31
<211>  1533
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  2e12-sss-IgG1 HL SMIP (PN)

<400>  31
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcc     60

agaggagtcc aggtgcagct gaaggagtca ggacctggcc tggtggcgcc ctcacagagc    120

ctgtccatca catgcaccgt ctcagggttc tcattaaccg gctatggtgt aaactgggtt    180

cgccagcctc caggaaaggg tctagagtgg ctgggaatga tatggggtga tggaagcaca    240

gactataatt cagctctcaa atccagacta tcgatcacca aggacaactc caagagccaa    300

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccagatacta ctgtgctcga    360

gatggttata gtaactttca ttactatgtt atggactact ggggtcaagg aacctcagtc    420

accgtctcct ctgggggtgg aggctctggt ggcggtggat ccggcggagg tgggtcgggt    480

ggcggcggat ctgacattgt gctcacccaa tctccagctt ctttggctgt gtctctaggt    540

cagagagcca ccatctcctg cagagccagt gaaagtgttg aatattatgt cacaagttta    600

atgcagtggt accaacagaa accaggacag ccacccaaac tcctcatctc tgctgctagc    660

aacgtagaat ctggggtccc tgccaggttt agtggcagtg ggtctgggac agactttagc    720

ctcaacatcc atcctgtgga ggaggatgat attgcaatgt atttctgtca gcaaagtagg    780

aaggttccat ggacgttcgg tggaggcacc aagctggaaa tcaaacgtga tcaggagccc    840

aaatcttctg acaaaactca cacatcccca ccgtccccag cacctgaact cctgggggga    900

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    960

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg   1020

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac   1080

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag   1140

gagtacaagt gcaaggtctc caacaaagcc ctcccagcct ccatcgagaa aacaatctcc   1200

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag   1260

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc   1320

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg   1380

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg   1440

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg   1500

cagaagagcc tctccctgtc tccgggtaaa tga                                1533


<210>  32
<211>  510
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2e12-sss-IgG1 HL SMIP (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (24)..(144)
<223>  VH

<220>
<221>  misc_feature
<222>  (145)..(164)
<223>  Linker

<220>
<221>  misc_feature
<222>  (165)..(276)
<223>  VL

<220>
<221>  misc_feature
<222>  (279)..(293)
<223>  Hinge

<400>  32

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Val Gln Val Gln Leu Lys Glu Ser Gly Pro 
            20                  25                  30          


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 
        35                  40                  45              


Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr 
65                  70                  75                  80  


Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn 
                85                  90                  95      


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
            100                 105                 110         


Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr 
        115                 120                 125             


Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
                165                 170                 175     


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
            180                 185                 190         


Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 
    210                 215                 220                 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
225                 230                 235                 240 


Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys 
                245                 250                 255     


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys Arg Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        275                 280                 285             


Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
    290                 295                 300                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
305                 310                 315                 320 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                325                 330                 335     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            340                 345                 350         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        355                 360                 365             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    370                 375                 380                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
385                 390                 395                 400 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                405                 410                 415     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            420                 425                 430         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        435                 440                 445             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    450                 455                 460                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
465                 470                 475                 480 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                485                 490                 495     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505                 510 


<210>  33
<211>  1518
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  2e12-sss-IgG1 LH SMIP (PN)

<400>  33
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcc     60

agaggagtcg acattgtgct cacccaatct ccagcttctt tggctgtgtc tctaggtcag    120

agagccacca tctcctgcag agccagtgaa agtgttgaat attatgtcac aagtttaatg    180

cagtggtacc aacagaaacc aggacagcca cccaaactcc tcatctctgc tgctagcaac    240

gtagaatctg gggtccctgc caggtttagt ggcagtgggt ctgggacaga ctttagcctc    300

aacatccatc ctgtggagga ggatgatatt gcaatgtatt tctgtcagca aagtaggaag    360

gttccatgga cgttcggtgg aggcaccaag ctggaaatca aacggggtgg cggtggatcc    420

ggcggaggtg ggtcgggtgg cggcggatct caggtgcagc tgaaggagtc aggacctggc    480

ctggtggcgc cctcacagag cctgtccatc acatgcaccg tctcagggtt ctcattaacc    540

ggctatggtg taaactgggt tcgccagcct ccaggaaagg gtctagagtg gctgggaatg    600

atatggggtg atggaagcac agactataat tcagctctca aatccagact atcgatcacc    660

aaggacaact ccaagagcca agttttctta aaaatgaaca gtctgcaaac tgatgacaca    720

gccagatact actgtgctcg agatggttat agtaactttc attactatgt tatggactac    780

tggggtcaag gaacctcagt caccgtctcc tctgatcagg agcccaaatc ttctgacaaa    840

actcacacat ccccaccgtc cccagcacct gaactcctgg ggggaccgtc agtcttcctc    900

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg    960

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg   1020

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg   1080

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag   1140

gtctccaaca aagccctccc agcccccatc gagaaaacaa tctccaaagc caaagggcag   1200

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag   1260

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag   1320

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc   1380

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc   1440

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc   1500

ctgtctccgg gtaaatga                                                 1518


<210>  34
<211>  505
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2e12-sss-IgG1 LH SMIP (AA)

<220>
<221>  misc_feature
<222>  (1)..(23)
<223>  Leader

<220>
<221>  misc_feature
<222>  (24)..(135)
<223>  VL

<220>
<221>  misc_feature
<222>  (136)..(150)
<223>  Linker

<220>
<221>  misc_feature
<222>  (151)..(271)
<223>  VH

<220>
<221>  misc_feature
<222>  (274)..(288)
<223>  Hinge

<400>  34

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Val Asp Ile Val Leu Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn 
65                  70                  75                  80  


Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met 
            100                 105                 110         


Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 
145                 150                 155                 160 


Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
                165                 170                 175     


Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp 
        195                 200                 205             


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser 
    210                 215                 220                 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
225                 230                 235                 240 


Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr 
                245                 250                 255     


Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Asp 
            260                 265                 270         


Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
        275                 280                 285             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    290                 295                 300                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
305                 310                 315                 320 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                325                 330                 335     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            340                 345                 350         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        355                 360                 365             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    370                 375                 380                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
385                 390                 395                 400 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                405                 410                 415     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            420                 425                 430         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        435                 440                 445             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    450                 455                 460                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
465                 470                 475                 480 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                485                 490                 495     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505 


<210>  35
<211>  1498
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  G28-1 LH SMIP (PN)

<400>  35
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca     60

gataccaccg gtgacatcca gatgactcag tctccagcct ccctatctgc atctgtggga    120

gagactgtca ccatcacatg tcgaacaagt gaaaatgttt acagttattt ggcttggtat    180

cagcagaaac agggaaaatc tcctcagctc ctggtctctt ttgcaaaaac cttagcagaa    240

ggtgtgccat caaggttcag tggcagtgga tcaggcacac agttttctct gaagatcagc    300

agcctgcagc ctgaagattc tggaagttat ttctgtcaac atcattccga taatccgtgg    360

acgttcggtg gaggcaccga actggagatc aaaggtggcg gtggctcggg cggtggtggg    420

tcgggtggcg gcggatctgc tagcgcagtc cagctgcagc agtctggacc tgagctggaa    480

aagcctggcg cttcagtgaa gatttcctgc aaggcttctg gttactcatt cactggctac    540

aatatgaact gggtgaagca gaataatgga aagagccttg agtggattgg aaatattgat    600

ccttattatg gtggtactac ctacaaccgg aagttcaagg gcaaggccac attgactgta    660

gacaaatcct ccagcacagc ctacatgcag ctcaagagtc tgacatctga ggactctgca    720

gtctattact gtgcaagatc ggtcggccct atggactact ggggtcaagg aacctcagtc    780

accgtctcga gcgagcccaa atcttctgac aaaactcaca catgcccacc gtgcccagca    840

cctgaactcc tgggtggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc    900

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct    960

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg   1020

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag   1080

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc   1140

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg   1200

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc   1260

ttctatccaa gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac   1320

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc   1380

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct   1440

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaagtg actctaga     1498


<210>  36
<211>  492
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  G28-1 LH SMIP (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Leader

<220>
<221>  misc_feature
<222>  (21)..(127)
<223>  VL

<220>
<221>  misc_feature
<222>  (128)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(260)
<223>  VH

<220>
<221>  misc_feature
<222>  (261)..(275)
<223>  Hinge

<400>  36

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn 
        35                  40                  45              


Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro 
    50                  55                  60                  


Gln Leu Leu Val Ser Phe Ala Lys Thr Leu Ala Glu Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ser Gly Ser Tyr Phe Cys Gln His His Ser 
            100                 105                 110         


Asp Asn Pro Trp Thr Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser 
    130                 135                 140                 


Ala Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
                165                 170                 175     


Asn Met Asn Trp Val Lys Gln Asn Asn Gly Lys Ser Leu Glu Trp Ile 
            180                 185                 190         


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
                245                 250                 255     


Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            260                 265                 270         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        275                 280                 285             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    290                 295                 300                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
305                 310                 315                 320 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                325                 330                 335     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            340                 345                 350         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        355                 360                 365             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    370                 375                 380                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
385                 390                 395                 400 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                405                 410                 415     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            420                 425                 430         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        435                 440                 445             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    450                 455                 460                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
465                 470                 475                 480 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490         


<210>  37
<211>  1522
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  G28-1 HL SMIP (PN)

<400>  37
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca     60

gataccaccg gtgcggtcca gctgcagcag tctggacctg agtcggaaaa gcctggcgct    120

tcagtgaaga tttcctgcaa ggcttctggt tactcattca ctggctacaa tatgaactgg    180

gtgaagcaga ataatggaaa gagccttgag tggattggaa atattgatcc ttattatggt    240

ggtactacct acaaccggaa gttcaagggc aaggccacat tgactgtaga caaatcctcc    300

ggcacagcct acatgcagct caagagtctg acatctgagg actctgcagt ctattactgt    360

gcaagatcgg tcggccctat ggactactgg ggtcaaggaa cctcagtcac cgtctcttct    420

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatcaggagg aggcgggagt    480

gctagcgaca tccagatgac tcagtctcca gcctccctat ctgcatctgt gggagagact    540

gtcaccatca catgtcgaac aagtgaaaat gtttacagtt atttggcttg gtatcagcag    600

aaacagggaa aatctcctca gctcctggtc tcttttgcaa aaaccttagc agaaggtgtg    660

ccatcaaggt tcagtggcag tggatcaggc acacagtttt ctctgaagat cagcagcctg    720

cagcctgaag attctggaag ttatttctgt caacatcatt ccgataatcc gtggacgttc    780

ggtggaggca ccgaactgga gatcaaaggc tcgagcgagc ccaaatcttc tgacaaaact    840

cacacatgcc caccgtgccc agcacctgaa ctcctgggtg gaccgtcagt cttcctcttc    900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg    960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag   1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc   1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc   1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc   1200

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc   1260

agcctgacct gcctggtcaa aggcttctat ccaagcgaca tcgccgtgga gtgggagagc   1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc   1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc   1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg   1500

tctccgggta agtgactcta ga                                            1522


<210>  38
<211>  500
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  G28-1 HL SMIP (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Leader

<220>
<221>  misc_feature
<222>  (21)..(136)
<223>  VH

<220>
<221>  misc_feature
<222>  (137)..(158)
<223>  Linker

<220>
<221>  misc_feature
<222>  (159)..(266)
<223>  VL

<220>
<221>  misc_feature
<222>  (268)..(283)
<223>  Hinge

<400>  38

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ala Val Gln Leu Gln Gln Ser Gly Pro Glu Ser Glu 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser 
        35                  40                  45              


Phe Thr Gly Tyr Asn Met Asn Trp Val Lys Gln Asn Asn Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Arg Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Gly Thr Ala Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Asp Ile 
145                 150                 155                 160 


Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Thr 
                165                 170                 175     


Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Val Tyr Ser Tyr Leu Ala 
            180                 185                 190         


Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val Ser Phe 
        195                 200                 205             


Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Gln Phe Ser Leu Lys Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Ser Gly Ser Tyr Phe Cys Gln His His Ser Asp Asn Pro Trp Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Glu Leu Glu Ile Lys Gly Ser Ser Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys 
            500 


<210>  39
<211>  1522
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  G19-4 LH SMIP (PN)

<400>  39
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca     60

gataccaccg gtgacatcca gatgacacag actacatcct ccctgtctgc ctctctggga    120

gacagagtca ccatcagttg cagggcaagt caggacattc gcaattattt aaactggtat    180

cagcagaaac cagatggaac tgttaaactc ctgatctact acacatcaag attacactca    240

ggagtcccat caaggttcag tggcagtggg tctggaacag attattctct caccattgcc    300

aacctgcaac cagaagatat tgccacttac ttttgccaac agggtaatac gcttccgtgg    360

acgttcggtg gaggcaccaa actggtaacc aaacggggtg gcggtggctc gggcggtggt    420

ggatctggag gaggtgggag cgctagcgag gtccagctgc aacagtctgg acctgaactg    480

gtgaagcctg gagcttcaat gaagatttcc tgcaaggcct ctggttactc attcactggc    540

tacatcgtga actggctgaa gcagagccat ggaaagaacc ttgagtggat tggacttatt    600

aatccataca aaggtcttac tacctacaac cagaaattca agggcaaggc cacattaact    660

gtagacaagt catccagcac agcctacatg gagctcctca gtctgacatc tgaagactct    720

gcagtctatt actgtgcaag atctgggtac tatggtgact cggactggta cttcgatgtc    780

tggggcgcag ggaccacggt caccgtctcc tcgagcgagc ccaaatcttc tgacaaaact    840

cacacatgcc caccgtgccc agcacctgaa ctcctgggtg gaccgtcagt cttcctcttc    900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg    960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag   1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc   1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc   1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc   1200

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc   1260

agcctgacct gcctggtcaa aggcttctat ccaagcgaca tcgccgtgga gtgggagagc   1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc   1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc   1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg   1500

tctccgggta agtgactcta ga                                            1522


<210>  40
<211>  499
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  G19-4 LH SMIP (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Leader

<220>
<221>  misc_feature
<222>  (21)..(128)
<223>  VL

<220>
<221>  misc_feature
<222>  (129)..(145)
<223>  Linker

<220>
<221>  misc_feature
<222>  (146)..(267)
<223>  VH

<220>
<221>  misc_feature
<222>  (268)..(282)
<223>  Hinge

<400>  40

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ala 
                85                  90                  95      


Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Val Thr Lys Arg 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
    130                 135                 140                 


Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
145                 150                 155                 160 


Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly 
                165                 170                 175     


Tyr Ile Val Asn Trp Leu Lys Gln Ser His Gly Lys Asn Leu Glu Trp 
            180                 185                 190         


Ile Gly Leu Ile Asn Pro Tyr Lys Gly Leu Thr Thr Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys 
            


<210>  41
<211>  1525
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  G19-4 HL SMIP (PN)

<400>  41
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca     60

gataccaccg gtgaggtcca gctgcaacag tctggacctg aactggtgaa gcctggagct    120

tcaatgaaga tttcctgcaa ggcctctggt tactcattca ctggctacat cgtgaactgg    180

ctgaagcaga gccatggaaa gaaccttgag tggattggac ttattaatcc atacaaaggt    240

cttactacct acaaccagaa attcaagggc aaggccacat tgactgtaga caagtcatcc    300

agcacagcct acatggagct cctcagtctg acatctgaag actctgcagt ctattactgt    360

gcaagatctg ggtactatgg tgactcagac tggtacttcg atgtctgggg cgcagggacc    420

acagtcaccg tctcctctgg cggcggtggc tcgggcggtg gtggatctgg aggaggtggg    480

agcgctagcg acatccagat gacacagact acatcctccc tgtctgcctc tctgggagac    540

agagtcacca tcagttgcag ggcaagtcag gacattcgca attatttgaa ctggtatcag    600

cagaaaccag atggaactgt taaactcctg atctactaca catcaagact acactcagga    660

gtcccatcaa ggttcagtgg cagtgggtct ggaacagatt attctctcac cattgccaac    720

ctgcaaccag aagatattgc cacttacttt tgccaacagg gtaatacact tccctggacg    780

ttcggtggag ggaccaaact ggtgaccaaa cgctcgagcg agcccaaatc ttctgacaaa    840

actcacacat gcccaccgtg cccagcacct gaactcctgg gtggaccgtc agtcttcctc    900

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg    960

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg   1020

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg   1080

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag   1140

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag   1200

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag   1260

gtcagcctga cctgcctggt caaaggcttc tatccaagcg acatcgccgt ggagtgggag   1320

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc   1380

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc   1440

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc   1500

ctgtctccgg gtaagtgact ctaga                                         1525


<210>  42
<211>  501
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  G19-4 HL SMIP (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Leader

<220>
<221>  misc_feature
<222>  (21)..(142)
<223>  VH

<220>
<221>  misc_feature
<222>  (143)..(159)
<223>  Linker

<220>
<221>  misc_feature
<222>  (160)..(267)
<223>  VL

<220>
<221>  misc_feature
<222>  (270)..(284)
<223>  Hinge

<400>  42

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser 
        35                  40                  45              


Phe Thr Gly Tyr Ile Val Asn Trp Leu Lys Gln Ser His Gly Lys Asn 
    50                  55                  60                  


Leu Glu Trp Ile Gly Leu Ile Asn Pro Tyr Lys Gly Leu Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu 
            180                 185                 190         


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
        195                 200                 205             


Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ala Asn Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Val Thr Lys Arg Ser Ser Glu Pro Lys 
            260                 265                 270         


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        275                 280                 285             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    290                 295                 300                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
305                 310                 315                 320 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                325                 330                 335     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            340                 345                 350         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        355                 360                 365             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    370                 375                 380                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
385                 390                 395                 400 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                405                 410                 415     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            420                 425                 430         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        435                 440                 445             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
465                 470                 475                 480 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                485                 490                 495     


Leu Ser Pro Gly Lys 
            500     


<210>  43
<211>  2328
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  n2H7sssIgG1-STD1-2e12HL (PN)

<400>  43
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca     60

gataccaccg gtcaaattgt tctctcccag tctccagcaa tcctgtctgc atctccaggg    120

gagaaggtca caatgacttg cagggccagc tcaagtgtaa gttacatgca ctggtaccag    180

cagaagccag gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga    240

gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac aatcagcaga    300

gtggaggctg aagatgctgc cacttattac tgccagcagt ggagttttaa cccacccacg    360

ttcggtgctg ggaccaagct ggagctgaaa gatggcggtg gctcgggcgg tggtggatct    420

ggaggaggtg gagctagcca ggcttatcta cagcagtctg gggctgagct ggtgaggcct    480

ggggcctcag tgaagatgtc ctgcaaggct tctggctaca catttaccag ttacaatatg    540

cactgggtaa agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga    600

aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac tgtagacaaa    660

tcctccagca cagcctacat gcagctcagc agcctgacat ctgaagactc tgcggtctat    720

ttctgtgcaa gagtggtgta ctatagtaac tcttactggt acttcgatgt ctggggcaca    780

gggaccacgg tcaccgtctc gagcgagccc aaatcttctg acaaaactca cacatcccca    840

ccgagcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc    900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc    960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc   1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc   1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc   1140

ctcccagccc ccatcgagaa aacaatctcc aaagccaaag ggcagccccg agaaccacag   1200

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc   1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg   1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac   1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg   1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaag   1500

aattatggtg gcggtggctc gggcggtggt ggatctggag gaggtgggag tgggaattct   1560

caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc   1620

acatgcaccg tctcagggtt ctcattaacc ggctatggtg taaactgggt tcgccagcct   1680

ccaggaaagg gtctggagtg gctgggaatg atatggggtg atggaagcac agactataat   1740

tcagctctca aatccagact atcgatcacc aaggacaact ccaagagcca agttttctta   1800

aaaatgaaca gtctgcaaac tgatgacaca gccagatact actgtgctcg agatggttat   1860

agtaactttc attactatgt tatggactac tggggtcaag gaacctcagt caccgtctcc   1920

tctgggggtg gaggctctgg tggcggtgga tccggcggag gtgggtcggg tggcggcgga   1980

tctgacattg tgctcaccca atctccagct tctttggctg tgtctctagg tcagagagcc   2040

accatctcct gcagagccag tgaaagtgtt gaatattatg tcacaagttt aatgcagtgg   2100

taccaacaga aaccaggaca gccacccaaa ctcctcatct ctgctgctag caacgtagaa   2160

tctggggtcc ctgccaggtt tagtggcagt gggtctggga cagactttag cctcaacatc   2220

catcctgtgg aggaggatga tattgcaatg tatttctgtc agcaaagtag gaaggttcca   2280

tggacgttcg gtggaggcac caagctggaa atcaaacgtt aatctaga                2328


<210>  44
<211>  769
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  n2H7sssIgG1-STD1-2e12HL (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Leader

<220>
<221>  misc_feature
<222>  (21)..(127)
<223>  VL

<220>
<221>  misc_feature
<222>  (128)..(142)
<223>  Linker

<220>
<221>  misc_feature
<222>  (143)..(264)
<223>  VH

<220>
<221>  misc_feature
<222>  (265)..(279)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (497)..(516)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (517)..(637)
<223>  VH2

<220>
<221>  misc_feature
<222>  (638)..(657)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (658)..(769)
<223>  VL2

<400>  44

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Asp Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Gln Ala 
    130                 135                 140                 


Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 
                165                 170                 175     


His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 
            180                 185                 190         


Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
225                 230                 235                 240 


Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr 
                245                 250                 255     


Gly Thr Thr Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr 
            260                 265                 270         


His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
305                 310                 315                 320 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 495     


Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val 
        515                 520                 525             


Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser 
    530                 535                 540                 


Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly 
545                 550                 555                 560 


Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn 
                565                 570                 575     


Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser 
            580                 585                 590         


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg 
        595                 600                 605             


Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met 
    610                 615                 620                 


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                645                 650                 655     


Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu 
            660                 665                 670         


Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr 
        675                 680                 685             


Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
    690                 695                 700                 


Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro 
705                 710                 715                 720 


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile 
                725                 730                 735     


His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser 
            740                 745                 750         


Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        755                 760                 765             


Arg 
    


<210>  45
<211>  2313
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  n2H7sssIgG1-STD2-2e12LH (PN)

<400>  45
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca     60

gataccaccg gtcaaattgt tctctcccag tctccagcaa tcctgtctgc atctccaggg    120

gagaaggtca caatgacttg cagggccagc tcaagtgtaa gttacatgca ctggtaccag    180

cagaagccag gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga    240

gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac aatcagcaga    300

gtggaggctg aagatgctgc cacttattac tgccagcagt ggagttttaa cccacccacg    360

ttcggtgctg ggaccaagct ggagctgaaa gatggcggtg gctcgggcgg tggtggatct    420

ggaggaggtg gagctagcca ggcttatcta cagcagtctg gggctgagct ggtgaggcct    480

ggggcctcag tgaagatgtc ctgcaaggct tctggctaca catttaccag ttacaatatg    540

cactgggtaa agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga    600

aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac tgtagacaaa    660

tcctccagca cagcctacat gcagctcagc agcctgacat ctgaagactc tgcggtctat    720

ttctgtgcaa gagtggtgta ctatagtaac tcttactggt acttcgatgt ctggggcaca    780

gggaccacgg tcaccgtctc gagcgagccc aaatcttctg acaaaactca cacatcccca    840

ccgagcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc    900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc    960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc   1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc   1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc   1140

ctcccagccc ccatcgagaa aacaatctcc aaagccaaag ggcagccccg agaaccacag   1200

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc   1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg   1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac   1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg   1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaag   1500

aattatggtg gcggtggctc gggcggtggt ggatctggag gaggtgggag tgggaattct   1560

gacattgtgc tcacccaatc tccagcttct ttggctgtgt ctctaggtca gagagccacc   1620

atctcctgca gagccagtga aagtgttgaa tattatgtca caagtttaat gcagtggtac   1680

caacagaaac caggacagcc acccaaactc ctcatctctg ctgctagcaa cgtagaatct   1740

ggggtccctg ccaggtttag tggcagtggg tctgggacag actttagcct caacatccat   1800

cctgtggagg aggatgatat tgcaatgtat ttctgtcagc aaagtaggaa ggttccatgg   1860

acgttcggtg gaggcaccaa gctggaaatc aaacggggtg gcggtggatc cggcggaggt   1920

gggtcgggtg gcggcggatc tcaggtgcag ctgaaggagt caggacctgg cctggtggcg   1980

ccctcacaga gcctgtccat cacatgcacc gtctcagggt tctcattaac cggctatggt   2040

gtaaactggg ttcgccagcc tccaggaaag ggtctggagt ggctgggaat gatatggggt   2100

gatggaagca cagactataa ttcagctctc aaatccagac tatcgatcac caaggacaac   2160

tccaagagcc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccagatac   2220

tactgtgctc gagatggtta tagtaacttt cattactatg ttatggacta ctggggtcaa   2280

ggaacctcag tcaccgtctc ctcttaatct aga                                2313


<210>  46
<211>  764
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  n2H7sssIgG1-STD2-2e12LH (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Leader

<220>
<221>  misc_feature
<222>  (21)..(126)
<223>  VL

<220>
<221>  misc_feature
<222>  (127)..(142)
<223>  Linker

<220>
<221>  misc_feature
<222>  (143)..(264)
<223>  VH

<220>
<221>  misc_feature
<222>  (265)..(279)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (497)..(516)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (517)..(628)
<223>  VL2

<220>
<221>  misc_feature
<222>  (629)..(643)
<223>  Linker

<220>
<221>  misc_feature
<222>  (644)..(764)
<223>  VH2

<400>  46

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Asp Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Gln Ala 
    130                 135                 140                 


Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 
                165                 170                 175     


His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 
            180                 185                 190         


Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
225                 230                 235                 240 


Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr 
                245                 250                 255     


Gly Thr Thr Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr 
            260                 265                 270         


His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
305                 310                 315                 320 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 495     


Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Asn Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
        515                 520                 525             


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
    530                 535                 540                 


Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
545                 550                 555                 560 


Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 
                565                 570                 575     


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
            580                 585                 590         


Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys 
        595                 600                 605             


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
    610                 615                 620                 


Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
625                 630                 635                 640 


Gly Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
                645                 650                 655     


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
            660                 665                 670         


Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
        675                 680                 685             


Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser 
    690                 695                 700                 


Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln 
705                 710                 715                 720 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr 
                725                 730                 735     


Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met Asp 
            740                 745                 750         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        755                 760                 


<210>  47
<211>  2048
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  n2H7sssIgG1-H1-2e12HL (PN)

<400>  47
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca     60

gataccaccg gtcaaattgt tctctcccag tctccagcaa tcctgtctgc atctccaggg    120

gagaaggtca caatgacttg cagggccagc tcaagtgtaa gttacatgca ctggtaccag    180

cagaagccag gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga    240

gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac aatcagcaga    300

gtggaggctg aagatgctgc cacttattac tgccagcagt ggagttttaa cccacccacg    360

ttcggtgctg ggaccaagct ggagctgaaa gatggcggtg gctcgggcgg tggtggatct    420

ggaggaggtg gagctagcca ggcttatcta cagcagtctg gggctgagct ggtgaggcct    480

ggggcctcag tgaagatgtc ctgcaaggct tctggctaca catttaccag ttacaatatg    540

cactgggtaa agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga    600

aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac tgtagacaaa    660

tcctccagca cagcctacat gcagctcagc agcctgacat ctgaagactc tgcggtctat    720

ttctgtgcaa gagtggtgta ctatagtaac tcttactggt acttcgatgt ctggggcaca    780

gggaccacgg tcaccgtctc gagcgagccc aaatcttctg acaaaactca cacatcccca    840

ccgagcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc    900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc    960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc   1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc   1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc   1140

ctcccagccc ccatcgagaa aacaatctcc aaagccaaag ggcagccccg agaaccacag   1200

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc   1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg   1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac   1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg   1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaag   1500

aattctcagg tgcagctgaa ggagtcagga cctggcctgg tggcgccctc acagagcctg   1560

tccatcacat gcaccgtctc agggttctca ttaaccggct atggtgtaaa ctgggttcgc   1620

cagcctccag gaaagggtct ggagtggctg ggaatgatat ggggtgatgg aagcacagac   1680

tataattcag ctctcaaatc cagactatcg atcaccaagg acaactccaa gagccaagtt   1740

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca gatactactg tgctcgagat   1800

ggttatagta actttcatta ctatgttatg gactactggg gtcaaggaac ctcagtcacc   1860

gtctcctctg ggggtggagg ctctggtggc ggtggatccg gcggaggtgg gtcgggtggc   1920

ggcggatctg acattgtgct cacccaatct ccagcttctt tggctgtgtc tctaggtcag   1980

agagccacca tctcctgcag agccagtgaa agtgttgaat attatgtcac aagtttaatg   2040

cagtggta                                                            2048


<210>  48
<211>  751
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  n2H7sssIgG1-H1-2e12HL (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Leader

<220>
<221>  misc_feature
<222>  (21)..(126)
<223>  VL

<220>
<221>  misc_feature
<222>  (127)..(142)
<223>  Linker

<220>
<221>  misc_feature
<222>  (143)..(264)
<223>  VH

<220>
<221>  misc_feature
<222>  (265)..(279)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (497)..(498)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (499)..(619)
<223>  VH2

<220>
<221>  misc_feature
<222>  (620)..(639)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (640)..(751)
<223>  VL2

<400>  48

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Asp Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Gln Ala 
    130                 135                 140                 


Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 
                165                 170                 175     


His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 
            180                 185                 190         


Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
225                 230                 235                 240 


Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr 
                245                 250                 255     


Gly Thr Thr Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr 
            260                 265                 270         


His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
305                 310                 315                 320 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 495     


Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro 
            500                 505                 510         


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
        515                 520                 525             


Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
    530                 535                 540                 


Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala 
545                 550                 555                 560 


Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val 
                565                 570                 575     


Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr 
            580                 585                 590         


Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met Asp Tyr 
        595                 600                 605             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
625                 630                 635                 640 


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
                645                 650                 655     


Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val 
            660                 665                 670         


Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        675                 680                 685             


Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg 
    690                 695                 700                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro 
705                 710                 715                 720 


Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys 
                725                 730                 735     


Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            740                 745                 750     


<210>  49
<211>  2292
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  n2H7sssIgG1-H2-2e12HL (PN)

<400>  49
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca     60

gataccaccg gtcaaattgt tctctcccag tctccagcaa tcctgtctgc atctccaggg    120

gagaaggtca caatgacttg cagggccagc tcaagtgtaa gttacatgca ctggtaccag    180

cagaagccag gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga    240

gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac aatcagcaga    300

gtggaggctg aagatgctgc cacttattac tgccagcagt ggagttttaa cccacccacg    360

ttcggtgctg ggaccaagct ggagctgaaa gatggcggtg gctcgggcgg tggtggatct    420

ggaggaggtg gagctagcca ggcttatcta cagcagtctg gggctgagct ggtgaggcct    480

ggggcctcag tgaagatgtc ctgcaaggct tctggctaca catttaccag ttacaatatg    540

cactgggtaa agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga    600

aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac tgtagacaaa    660

tcctccagca cagcctacat gcagctcagc agcctgacat ctgaagactc tgcggtctat    720

ttctgtgcaa gagtggtgta ctatagtaac tcttactggt acttcgatgt ctggggcaca    780

gggaccacgg tcaccgtctc gagcgagccc aaatcttctg acaaaactca cacatcccca    840

ccgagcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc    900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc    960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc   1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc   1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc   1140

ctcccagccc ccatcgagaa aacaatctcc aaagccaaag ggcagccccg agaaccacag   1200

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc   1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg   1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac   1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg   1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaag   1500

ggtggcggtg gctcggggaa ttctcaggtg cagctgaagg agtcaggacc tggcctggtg   1560

gcgccctcac agagcctgtc catcacatgc accgtctcag ggttctcatt aaccggctat   1620

ggtgtaaact gggttcgcca gcctccagga aagggtctgg agtggctggg aatgatatgg   1680

ggtgatggaa gcacagacta taattcagct ctcaaatcca gactatcgat caccaaggac   1740

aactccaaga gccaagtttt cttaaaaatg aacagtctgc aaactgatga cacagccaga   1800

tactactgtg ctcgagatgg ttatagtaac tttcattact atgttatgga ctactggggt   1860

caaggaacct cagtcaccgt ctcctctggg ggtggaggct ctggtggcgg tggatccggc   1920

ggaggtgggt cgggtggcgg cggatctgac attgtgctca cccaatctcc agcttctttg   1980

gctgtgtctc taggtcagag agccaccatc tcctgcagag ccagtgaaag tgttgaatat   2040

tatgtcacaa gtttaatgca gtggtaccaa cagaaaccag gacagccacc caaactcctc   2100

atctctgctg ctagcaacgt agaatctggg gtccctgcca ggtttagtgg cagtgggtct   2160

gggacagact ttagcctcaa catccatcct gtggaggagg atgatattgc aatgtatttc   2220

tgtcagcaaa gtaggaaggt tccatggacg ttcggtggag gcaccaagct ggaaatcaaa   2280

cgttaatcta ga                                                       2292


<210>  50
<211>  757
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  n2H7sssIgG1-H2-2e12HL (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Leader

<220>
<221>  misc_feature
<222>  (21)..(126)
<223>  VL

<220>
<221>  misc_feature
<222>  (127)..(142)
<223>  Linker

<220>
<221>  misc_feature
<222>  (143)..(264)
<223>  VH

<220>
<221>  misc_feature
<222>  (265)..(279)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (497)..(504)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (505)..(625)
<223>  VH2

<220>
<221>  misc_feature
<222>  (626)..(645)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (646)..(757)
<223>  VL2

<400>  50

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Asp Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Gln Ala 
    130                 135                 140                 


Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 
                165                 170                 175     


His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 
            180                 185                 190         


Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
225                 230                 235                 240 


Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr 
                245                 250                 255     


Gly Thr Thr Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr 
            260                 265                 270         


His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
305                 310                 315                 320 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 495     


Gly Gly Gly Gly Ser Gly Asn Ser Gln Val Gln Leu Lys Glu Ser Gly 
            500                 505                 510         


Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val 
        515                 520                 525             


Ser Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro 
    530                 535                 540                 


Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser 
545                 550                 555                 560 


Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp 
                565                 570                 575     


Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp 
            580                 585                 590         


Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His 
        595                 600                 605             


Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
    610                 615                 620                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
                645                 650                 655     


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
            660                 665                 670         


Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys 
        675                 680                 685             


Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu 
    690                 695                 700                 


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
705                 710                 715                 720 


Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe 
                725                 730                 735     


Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys 
            740                 745                 750         


Leu Glu Ile Lys Arg 
        755         


<210>  51
<211>  2298
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  n2H7sssIgG1-H3-2e12HL (PN)

<400>  51
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca     60

gataccaccg gtcaaattgt tctctcccag tctccagcaa tcctgtctgc atctccaggg    120

gagaaggtca caatgacttg cagggccagc tcaagtgtaa gttacatgca ctggtaccag    180

cagaagccag gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga    240

gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac aatcagcaga    300

gtggaggctg aagatgctgc cacttattac tgccagcagt ggagttttaa cccacccacg    360

ttcggtgctg ggaccaagct ggagctgaaa gatggcggtg gctcgggcgg tggtggatct    420

ggaggaggtg gagctagcca ggcttatcta cagcagtctg gggctgagct ggtgaggcct    480

ggggcctcag tgaagatgtc ctgcaaggct tctggctaca catttaccag ttacaatatg    540

cactgggtaa agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga    600

aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac tgtagacaaa    660

tcctccagca cagcctacat gcagctcagc agcctgacat ctgaagactc tgcggtctat    720

ttctgtgcaa gagtggtgta ctatagtaac tcttactggt acttcgatgt ctggggcaca    780

gggaccacgg tcaccgtctc gagcgagccc aaatcttctg acaaaactca cacatcccca    840

ccgagcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc    900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc    960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc   1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc   1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc   1140

ctcccagccc ccatcgagaa aacaatctcc aaagccaaag ggcagccccg agaaccacag   1200

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc   1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg   1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac   1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg   1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaag   1500

aattatggtg gcggtggctc tgggaattct caggtgcagc tgaaggagtc aggacctggc   1560

ctggtggcgc cctcacagag cctgtccatc acatgcaccg tctcagggtt ctcattaacc   1620

ggctatggtg taaactgggt tcgccagcct ccaggaaagg gtctggagtg gctgggaatg   1680

atatggggtg atggaagcac agactataat tcagctctca aatccagact atcgatcacc   1740

aaggacaact ccaagagcca agttttctta aaaatgaaca gtctgcaaac tgatgacaca   1800

gccagatact actgtgctcg agatggttat agtaactttc attactatgt tatggactac   1860

tggggtcaag gaacctcagt caccgtctcc tctgggggtg gaggctctgg tggcggtgga   1920

tccggcggag gtgggtcggg tggcggcgga tctgacattg tgctcaccca atctccagct   1980

tctttggctg tgtctctagg tcagagagcc accatctcct gcagagccag tgaaagtgtt   2040

gaatattatg tcacaagttt aatgcagtgg taccaacaga aaccaggaca gccacccaaa   2100

ctcctcatct ctgctgctag caacgtagaa tctggggtcc ctgccaggtt tagtggcagt   2160

gggtctggga cagactttag cctcaacatc catcctgtgg aggaggatga tattgcaatg   2220

tatttctgtc agcaaagtag gaaggttcca tggacgttcg gtggaggcac caagctggaa   2280

atcaaacgtt aatctaga                                                 2298


<210>  52
<211>  759
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  n2H7sssIgG1-H3-2e12HL (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Leader

<220>
<221>  misc_feature
<222>  (21)..(126)
<223>  VL

<220>
<221>  misc_feature
<222>  (127)..(142)
<223>  Linker

<220>
<221>  misc_feature
<222>  (143)..(264)
<223>  VH

<220>
<221>  misc_feature
<222>  (265)..(279)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (497)..(506)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (507)..(627)
<223>  VH2

<220>
<221>  misc_feature
<222>  (628)..(647)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (648)..(759)
<223>  VL2

<400>  52

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Asp Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Gln Ala 
    130                 135                 140                 


Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 
                165                 170                 175     


His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 
            180                 185                 190         


Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
225                 230                 235                 240 


Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr 
                245                 250                 255     


Gly Thr Thr Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr 
            260                 265                 270         


His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
305                 310                 315                 320 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 495     


Asn Tyr Gly Gly Gly Gly Ser Gly Asn Ser Gln Val Gln Leu Lys Glu 
            500                 505                 510         


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys 
        515                 520                 525             


Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg 
    530                 535                 540                 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp 
545                 550                 555                 560 


Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr 
                565                 570                 575     


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
            580                 585                 590         


Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn 
        595                 600                 605             


Phe His Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
    610                 615                 620                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
                645                 650                 655     


Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
            660                 665                 670         


Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln 
        675                 680                 685             


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn 
    690                 695                 700                 


Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
705                 710                 715                 720 


Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met 
                725                 730                 735     


Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly 
            740                 745                 750         


Thr Lys Leu Glu Ile Lys Arg 
        755                 


<210>  53
<211>  2307
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  n2H7sssIgG1-H4-2e12HL (PN)

<400>  53
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca     60

gataccaccg gtcaaattgt tctctcccag tctccagcaa tcctgtctgc atctccaggg    120

gagaaggtca caatgacttg cagggccagc tcaagtgtaa gttacatgca ctggtaccag    180

cagaagccag gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga    240

gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac aatcagcaga    300

gtggaggctg aagatgctgc cacttattac tgccagcagt ggagttttaa cccacccacg    360

ttcggtgctg ggaccaagct ggagctgaaa gatggcggtg gctcgggcgg tggtggatct    420

ggaggaggtg gagctagcca ggcttatcta cagcagtctg gggctgagct ggtgaggcct    480

ggggcctcag tgaagatgtc ctgcaaggct tctggctaca catttaccag ttacaatatg    540

cactgggtaa agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga    600

aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac tgtagacaaa    660

tcctccagca cagcctacat gcagctcagc agcctgacat ctgaagactc tgcggtctat    720

ttctgtgcaa gagtggtgta ctatagtaac tcttactggt acttcgatgt ctggggcaca    780

gggaccacgg tcaccgtctc gagcgagccc aaatcttctg acaaaactca cacatcccca    840

ccgagcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc    900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc    960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc   1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc   1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc   1140

ctcccagccc ccatcgagaa aacaatctcc aaagccaaag ggcagccccg agaaccacag   1200

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc   1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg   1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac   1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg   1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaag   1500

ggtggcggtg gctcgggcgg tggtggatct gggaattctc aggtgcagct gaaggagtca   1560

ggacctggcc tggtggcgcc ctcacagagc ctgtccatca catgcaccgt ctcagggttc   1620

tcattaaccg gctatggtgt aaactgggtt cgccagcctc caggaaaggg tctggagtgg   1680

ctgggaatga tatggggtga tggaagcaca gactataatt cagctctcaa atccagacta   1740

tcgatcacca aggacaactc caagagccaa gttttcttaa aaatgaacag tctgcaaact   1800

gatgacacag ccagatacta ctgtgctcga gatggttata gtaactttca ttactatgtt   1860

atggactact ggggtcaagg aacctcagtc accgtctcct ctgggggtgg aggctctggt   1920

ggcggtggat ccggcggagg tgggtcgggt ggcggcggat ctgacattgt gctcacccaa   1980

tctccagctt ctttggctgt gtctctaggt cagagagcca ccatctcctg cagagccagt   2040

gaaagtgttg aatattatgt cacaagttta atgcagtggt accaacagaa accaggacag   2100

ccacccaaac tcctcatctc tgctgctagc aacgtagaat ctggggtccc tgccaggttt   2160

agtggcagtg ggtctgggac agactttagc ctcaacatcc atcctgtgga ggaggatgat   2220

attgcaatgt atttctgtca gcaaagtagg aaggttccat ggacgttcgg tggaggcacc   2280

aagctggaaa tcaaacgtta atctaga                                       2307


<210>  54
<211>  762
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  n2H7sssIgG1-H4-2e12HL (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Leader

<220>
<221>  misc_feature
<222>  (21)..(126)
<223>  VL

<220>
<221>  misc_feature
<222>  (127)..(142)
<223>  Linker

<220>
<221>  misc_feature
<222>  (143)..(264)
<223>  VH

<220>
<221>  misc_feature
<222>  (265)..(279)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (497)..(509)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (510)..(630)
<223>  VH2

<220>
<221>  misc_feature
<222>  (631)..(650)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (651)..(762)
<223>  VL2

<400>  54

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Asp Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Gln Ala 
    130                 135                 140                 


Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 
                165                 170                 175     


His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 
            180                 185                 190         


Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
225                 230                 235                 240 


Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr 
                245                 250                 255     


Gly Thr Thr Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr 
            260                 265                 270         


His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
305                 310                 315                 320 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 495     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser Gln Val Gln 
            500                 505                 510         


Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
        515                 520                 525             


Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn 
    530                 535                 540                 


Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile 
545                 550                 555                 560 


Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
                565                 570                 575     


Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
            580                 585                 590         


Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly 
        595                 600                 605             


Tyr Ser Asn Phe His Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr 
    610                 615                 620                 


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
                645                 650                 655     


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
            660                 665                 670         


Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln 
        675                 680                 685             


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala 
    690                 695                 700                 


Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
705                 710                 715                 720 


Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp 
                725                 730                 735     


Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe 
            740                 745                 750         


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        755                 760         


<210>  55
<211>  2313
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  n2H7sssIgG1-H5-2e12HL (PN)

<400>  55
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca     60

gataccaccg gtcaaattgt tctctcccag tctccagcaa tcctgtctgc atctccaggg    120

gagaaggtca caatgacttg cagggccagc tcaagtgtaa gttacatgca ctggtaccag    180

cagaagccag gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga    240

gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac aatcagcaga    300

gtggaggctg aagatgctgc cacttattac tgccagcagt ggagttttaa cccacccacg    360

ttcggtgctg ggaccaagct ggagctgaaa gatggcggtg gctcgggcgg tggtggatct    420

ggaggaggtg gagctagcca ggcttatcta cagcagtctg gggctgagct ggtgaggcct    480

ggggcctcag tgaagatgtc ctgcaaggct tctggctaca catttaccag ttacaatatg    540

cactgggtaa agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga    600

aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac tgtagacaaa    660

tcctccagca cagcctacat gcagctcagc agcctgacat ctgaagactc tgcggtctat    720

ttctgtgcaa gagtggtgta ctatagtaac tcttactggt acttcgatgt ctggggcaca    780

gggaccacgg tcaccgtctc gagcgagccc aaatcttctg acaaaactca cacatcccca    840

ccgagcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc    900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc    960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc   1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc   1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc   1140

ctcccagccc ccatcgagaa aacaatctcc aaagccaaag ggcagccccg agaaccacag   1200

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc   1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg   1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac   1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg   1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaag   1500

aattatggtg gcggtggctc gggcggtggt ggatctggga attctcaggt gcagctgaag   1560

gagtcaggac ctggcctggt ggcgccctca cagagcctgt ccatcacatg caccgtctca   1620

gggttctcat taaccggcta tggtgtaaac tgggttcgcc agcctccagg aaagggtctg   1680

gagtggctgg gaatgatatg gggtgatgga agcacagact ataattcagc tctcaaatcc   1740

agactatcga tcaccaagga caactccaag agccaagttt tcttaaaaat gaacagtctg   1800

caaactgatg acacagccag atactactgt gctcgagatg gttatagtaa ctttcattac   1860

tatgttatgg actactgggg tcaaggaacc tcagtcaccg tctcctctgg gggtggaggc   1920

tctggtggcg gtggatccgg cggaggtggg tcgggtggcg gcggatctga cattgtgctc   1980

acccaatctc cagcttcttt ggctgtgtct ctaggtcaga gagccaccat ctcctgcaga   2040

gccagtgaaa gtgttgaata ttatgtcaca agtttaatgc agtggtacca acagaaacca   2100

ggacagccac ccaaactcct catctctgct gctagcaacg tagaatctgg ggtccctgcc   2160

aggtttagtg gcagtgggtc tgggacagac tttagcctca acatccatcc tgtggaggag   2220

gatgatattg caatgtattt ctgtcagcaa agtaggaagg ttccatggac gttcggtgga   2280

ggcaccaagc tggaaatcaa acgttaatct aga                                2313


<210>  56
<211>  764
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  n2H7sssIgG1-H5-2e12HL (AA)

<220>
<221>  misc_feature
<222>  (11)..(20)
<223>  Leader

<220>
<221>  misc_feature
<222>  (21)..(126)
<223>  VL

<220>
<221>  misc_feature
<222>  (127)..(142)
<223>  Linker

<220>
<221>  misc_feature
<222>  (143)..(264)
<223>  VH

<220>
<221>  misc_feature
<222>  (265)..(279)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (497)..(511)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (512)..(632)
<223>  VH2

<220>
<221>  misc_feature
<222>  (633)..(652)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (653)..(764)
<223>  VL2

<400>  56

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Asp Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Gln Ala 
    130                 135                 140                 


Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 
                165                 170                 175     


His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 
            180                 185                 190         


Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
225                 230                 235                 240 


Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr 
                245                 250                 255     


Gly Thr Thr Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr 
            260                 265                 270         


His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
305                 310                 315                 320 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 495     


Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser Gln 
            500                 505                 510         


Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
        515                 520                 525             


Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr Gly 
    530                 535                 540                 


Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly 
545                 550                 555                 560 


Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser 
                565                 570                 575     


Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
            580                 585                 590         


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg 
        595                 600                 605             


Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met Asp Tyr Trp Gly Gln 
    610                 615                 620                 


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu 
                645                 650                 655     


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr 
            660                 665                 670         


Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu 
        675                 680                 685             


Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
    690                 695                 700                 


Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly 
705                 710                 715                 720 


Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu 
                725                 730                 735     


Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp 
            740                 745                 750         


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        755                 760                 


<210>  57
<211>  2322
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  n2H7sssIgG1-H6-2e12HL (PN)

<400>  57
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca     60

gataccaccg gtcaaattgt tctctcccag tctccagcaa tcctgtctgc atctccaggg    120

gagaaggtca caatgacttg cagggccagc tcaagtgtaa gttacatgca ctggtaccag    180

cagaagccag gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga    240

gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac aatcagcaga    300

gtggaggctg aagatgctgc cacttattac tgccagcagt ggagttttaa cccacccacg    360

ttcggtgctg ggaccaagct ggagctgaaa gatggcggtg gctcgggcgg tggtggatct    420

ggaggaggtg gagctagcca ggcttatcta cagcagtctg gggctgagct ggtgaggcct    480

ggggcctcag tgaagatgtc ctgcaaggct tctggctaca catttaccag ttacaatatg    540

cactgggtaa agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga    600

aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac tgtagacaaa    660

tcctccagca cagcctacat gcagctcagc agcctgacat ctgaagactc tgcggtctat    720

ttctgtgcaa gagtggtgta ctatagtaac tcttactggt acttcgatgt ctggggcaca    780

gggaccacgg tcaccgtctc gagcgagccc aaatcttctg acaaaactca cacatcccca    840

ccgagcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc    900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc    960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc   1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc   1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc   1140

ctcccagccc ccatcgagaa aacaatctcc aaagccaaag ggcagccccg agaaccacag   1200

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc   1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg   1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac   1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg   1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaag   1500

ggtggcggtg gctcgggcgg tggtggatct gggggaggag gcagcgggaa ttctcaggtg   1560

cagctgaagg agtcaggacc tggcctggtg gcgccctcac agagcctgtc catcacatgc   1620

accgtctcag ggttctcatt aaccggctat ggtgtaaact gggttcgcca gcctccagga   1680

aagggtctgg agtggctggg aatgatatgg ggtgatggaa gcacagacta taattcagct   1740

ctcaaatcca gactatcgat caccaaggac aactccaaga gccaagtttt cttaaaaatg   1800

aacagtctgc aaactgatga cacagccaga tactactgtg ctcgagatgg ttatagtaac   1860

tttcattact atgttatgga ctactggggt caaggaacct cagtcaccgt ctcctctggg   1920

ggtggaggct ctggtggcgg tggatccggc ggaggtgggt cgggtggcgg cggatctgac   1980

attgtgctca cccaatctcc agcttctttg gctgtgtctc taggtcagag agccaccatc   2040

tcctgcagag ccagtgaaag tgttgaatat tatgtcacaa gtttaatgca gtggtaccaa   2100

cagaaaccag gacagccacc caaactcctc atctctgctg ctagcaacgt agaatctggg   2160

gtccctgcca ggtttagtgg cagtgggtct gggacagact ttagcctcaa catccatcct   2220

gtggaggagg atgatattgc aatgtatttc tgtcagcaaa gtaggaaggt tccatggacg   2280

ttcggtggag gcaccaagct ggaaatcaaa cgttaatcta ga                      2322


<210>  58
<211>  767
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  n2H7sssIgG1-H6-2e12HL (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Leader

<220>
<221>  misc_feature
<222>  (21)..(126)
<223>  VL

<220>
<221>  misc_feature
<222>  (127)..(142)
<223>  Linker

<220>
<221>  misc_feature
<222>  (143)..(264)
<223>  VH

<220>
<221>  misc_feature
<222>  (265)..(279)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (497)..(514)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (515)..(635)
<223>  VH2

<220>
<221>  misc_feature
<222>  (636)..(655)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (656)..(767)
<223>  VL2

<400>  58

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Asp Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Gln Ala 
    130                 135                 140                 


Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 
                165                 170                 175     


His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 
            180                 185                 190         


Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
225                 230                 235                 240 


Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr 
                245                 250                 255     


Gly Thr Thr Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr 
            260                 265                 270         


His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
305                 310                 315                 320 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 495     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro 
        515                 520                 525             


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
    530                 535                 540                 


Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
545                 550                 555                 560 


Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala 
                565                 570                 575     


Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val 
            580                 585                 590         


Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr 
        595                 600                 605             


Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met Asp Tyr 
    610                 615                 620                 


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                645                 650                 655     


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
            660                 665                 670         


Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val 
        675                 680                 685             


Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
    690                 695                 700                 


Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg 
705                 710                 715                 720 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro 
                725                 730                 735     


Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys 
            740                 745                 750         


Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        755                 760                 765         


<210>  59
<211>  2337
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  2H7cscIgG1-STD1-2e12HL (PN)

<400>  59
aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca     60

gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct    120

ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg    180

taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct    240

tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc    300

agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca    360

cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt    420

ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg    480

aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac    540

aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat    600

ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta    660

gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg    720

gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg    780

ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttgtga caaaactcac    840

acatccccac cgtgctcagc acctgaactc ctggggggac cgtcagtctt cctcttcccc    900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg   1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc   1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc   1140

aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga   1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc   1260

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat   1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1500

ccgggtaaga attatggtgg cggtggctcg ggcggtggtg gatctggagg aggtgggagt   1560

gggaattctc aggtgcagct gaaggagtca ggacctggcc tggtggcgcc ctcacagagc   1620

ctgtccatca catgcaccgt ctcagggttc tcattaaccg gctatggtgt aaactgggtt   1680

cgccagcctc caggaaaggg tctggagtgg ctgggaatga tatggggtga tggaagcaca   1740

gactataatt cagctctcaa atccagacta tcgatcacca aggacaactc caagagccaa   1800

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccagatacta ctgtgctcga   1860

gatggttata gtaactttca ttactatgtt atggactact ggggtcaagg aacctcagtc   1920

accgtctcct ctgggggtgg aggctctggt ggcggtggat ccggcggagg tgggtcgggt   1980

ggcggcggat ctgacattgt gctcacccaa tctccagctt ctttggctgt gtctctaggt   2040

cagagagcca ccatctcctg cagagccagt gaaagtgttg aatattatgt cacaagttta   2100

atgcagtggt accaacagaa accaggacag ccacccaaac tcctcatctc tgctgctagc   2160

aacgtagaat ctggggtccc tgccaggttt agtggcagtg ggtctgggac agactttagc   2220

ctcaacatcc atcctgtgga ggaggatgat attgcaatgt atttctgtca gcaaagtagg   2280

aaggttccat ggacgttcgg tggaggcacc aagctggaaa tcaaacgtta atctaga      2337


<210>  60
<211>  772
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  2H7cscIgG1-STD1-2e12HL (w/2E12 leader) (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(128)
<223>  VL

<220>
<221>  misc_feature
<222>  (129)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH

<220>
<221>  misc_feature
<222>  (268)..(282)
<223>  Hinge

<220>
<221>  misc_feature
<222>  (500)..(519)
<223>  EFD-BD2 Linker

<220>
<221>  misc_feature
<222>  (520)..(640)
<223>  VH2

<220>
<221>  misc_feature
<222>  (641)..(660)
<223>  Linker2

<220>
<221>  misc_feature
<222>  (661)..(772)
<223>  VL2

<400>  60

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Lys Thr His Thr Ser Pro Pro Cys Ser Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro 
        515                 520                 525             


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 
    530                 535                 540                 


Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro 
545                 550                 555                 560 


Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr 
                565                 570                 575     


Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn 
            580                 585                 590         


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
        595                 600                 605             


Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr 
    610                 615                 620                 


Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            660                 665                 670         


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        675                 680                 685             


Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
    690                 695                 700                 


Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 
705                 710                 715                 720 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
                725                 730                 735     


Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys 
            740                 745                 750         


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        755                 760                 765             


Glu Ile Lys Arg 
    770         


<210>  61
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Hinge csc(p) -hIgG1 (PN)

<400>  61
gagcccaaat cttgtgacaa aactcacaca tctccaccgt gccca                     45


<210>  62
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge csc(p) -hIgG1 (AA)

<400>  62

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  63
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human IgG1 (CCC) hinge domain (AA)

<400>  63

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  64
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Hinge ssc(s)-hIgG1 (PN)

<400>  64
gagcccaaat cttctgacaa aactcacaca tctccaccgt gctca                     45


<210>  65
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge ssc(s)-hIgG1 (AA)

<400>  65

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  66
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Hinge scc(s)-hIgG1 (PN)

<400>  66
gagcccaaat cttctgacaa aactcacaca tgtccaccgt gctca                     45


<210>  67
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge scc(s)-hIgG1 (AA)

<400>  67

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  68
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Hinge css(s)-hIgG1 (PN)

<400>  68
gagcccaaat cttgtgacaa aactcacaca tctccaccga gctca                     45


<210>  69
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge css(s)-hIgG1 (AA)

<400>  69

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  70
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Hinge scs(s) -hIgG1 (PN)

<400>  70
gagcccaaat cttgtgacaa aactcacaca tgtccaccga gctca                     45


<210>  71
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge scs(s) -hIgG1 (AA)

<400>  71

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  72
<211>  90
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Hinge ccc(s) -hIgG1 (PN)

<400>  72
gagcccaaat cttctgacaa aactcacaca tctccaccgt gcccagagcc caaatcttgt     60

gacaaaactc acacatgtcc accgtgctca                                      90


<210>  73
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge ccc(s) -hIgG1 (AA)

<400>  73

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  74
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Hinge ccc(p) -hIgG1 (PN)

<400>  74
gagcccaaat cttgtgacaa aactcacaca tgtccaccgt gccca                     45


<210>  75
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  Hinge ccc(p) -hIgG1 (AA)

<400>  75

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  76
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  Hinge sss(p) -hIgG1 (PN)

<400>  76
gagcccaaat cttctgacaa aactcacaca tctccaccga gccca                     45


<210>  77
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  Hinge sss(p) -hIgG1 (AA)

<400>  77

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  78
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  Hinge ssc(p) -hIgG1 (PN)

<400>  78
gagcccaaat cttctgacaa aactcacaca tctccaccgt gccca                     45


<210>  79
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge ssc(p) -hIgG1 (AA)

<400>  79

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  80
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Hinge scc(p) -hIgG1 (PN)

<400>  80
gagcccaaat cttctgacaa aactcacaca tgtccaccgt gccca                     45


<210>  81
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge scc(p) -hIgG1 (AA)

<400>  81

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  82
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Hinge css(p) -hIgG1 (PN)

<400>  82
gagcccaaat cttgtgacaa aactcacaca tctccaccga gccca                     45


<210>  83
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge css(p) -hIgG1 (AA)

<400>  83

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  84
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Hinge scs(p) -hIgG1 (PN)

<400>  84
gagcccaaat cttgtgacaa aactcacaca tgtccaccga gccca                     45


<210>  85
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge scs(p) -hIgG1 (AA)

<400>  85

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  86
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Hinge scppcp (PN)

<400>  86
agttgtccac cgtgccca                                                   18


<210>  87
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge scppcp (AA)

<400>  87

Ser Cys Pro Pro Cys Pro 
1               5       


<210>  88
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  88
gagcccaaat cttctgacaa aactcacaca tctccaccga gctca                     45


<210>  89
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  89

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  90
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  90
gagcccaaat cttgtgacaa aactcacaca tctccaccgt gctca                     45


<210>  91
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  91

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  92
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge - wild-type

<400>  92

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  93
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  93

Gly Gly Gly Gly Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  94
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge 2

<400>  94

Glu Pro Lys Ser Cys Gly Gly Gly Gly Gly Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  95
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  95

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Gly Gly Cys Pro 
1               5                   10                  15  


<210>  96
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge 4

<400>  96

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Gly 
1               5                   10                  15  


<210>  97
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  97

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  98
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge 6

<400>  98

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  99
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  99

Glu Pro Lys Ser Cys Asp Lys Cys His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  100
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge 8

<400>  100

Glu Pro Lys Ser Cys Asp Lys Thr Cys Cys Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  101
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge 9

<400>  101

Glu Pro Lys Ser Cys Pro Pro Pro Pro Pro Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  102
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  102

Pro Pro Pro Pro Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  103
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge 11

<400>  103

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Cys Pro 
1               5                   10              


<210>  104
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge 12

<400>  104

Glu Pro Lys Ser Cys Asp Lys Thr Cys Pro Pro Cys Pro 
1               5                   10              


<210>  105
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  105

Glu Pro Lys Ser Cys Asp Lys Thr Cys Cys Pro 
1               5                   10      


<210>  106
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge 14

<400>  106

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Gly Gly Gly Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  107
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge 15

<400>  107

Glu Pro Lys Ser Cys Asp Gly Gly Gly Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  108
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  108

Glu Pro Lys Ser Cys Asp Pro Pro Pro Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  109
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge 17

<400>  109

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Pro Pro Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  110
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge 18

<400>  110

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Trp Trp Cys Pro 
1               5                   10                  15  


<210>  111
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  111

Glu Pro Lys Ser Cys Asp Trp Trp His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  112
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge 20

<400>  112

Glu Pro Lys Cys Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  113
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  113

Glu Pro Lys Ser Asp Cys Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  114
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge 22

<400>  114

Glu Pro Lys Ser Asp Cys Trp Trp His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  115
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  115

Glu Pro Lys Ser Cys Asp Phe Phe His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  116
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge 24

<400>  116

Glu Pro Lys Ser Cys Asp Trp Trp Trp Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  117
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  117

Glu Pro Lys Ser Cys Trp Trp Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  118
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Hinge 26

<400>  118

Glu Pro Trp Trp Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  119
<211>  795
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  anti-CD20 (2H7) LH (PN)

<400>  119
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcc     60

agaggacaaa ttgttctctc ccagtctcca gcaatcctgt ctgcatctcc aggggagaag    120

gtcacaatga cttgcagggc cagctcaagt gtaagttaca tgcactggta ccagcagaag    180

ccaggatcct cccccaaacc ctggatttat gccccatcca acctggcttc tggagtccct    240

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagagtggag    300

gctgaagatg ctgccactta ttactgccag cagtggagtt ttaacccacc cacgttcggt    360

gctgggacca agctggagct gaaagatggc ggtggctcgg gcggtggtgg atctggagga    420

ggtgggagct ctcaggctta tctacagcag tctggggctg agtcggtgag gcctggggcc    480

tcagtgaaga tgtcctgcaa ggcttctggc tacacattta ccagttacaa tatgcactgg    540

gtaaagcaga cacctagaca gggcctggaa tggattggag ctatttatcc aggaaatggt    600

gatacttcct acaatcagaa gttcaagggc aaggccacac tgactgtaga caaatcctcc    660

agcacagcct acatgcagct cagcagcctg acatctgaag actctgcggt ctatttctgt    720

gcaagagtgg tgtactatag taactcttac tggtacttcg atgtctgggg cacagggacc    780

acggtcaccg tctct                                                     795


<210>  120
<211>  265
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  anti-CD20 (2H7) LH (AA)

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Leader

<220>
<221>  misc_feature
<222>  (23)..(128)
<223>  VL

<220>
<221>  misc_feature
<222>  (129)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(265)
<223>  VH

<400>  120

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Thr Gly Thr Thr Val Thr Val Ser 
            260                 265 


<210>  121
<211>  717
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  121
caggtgcagc tggtgcagtc tggtgctgag agcaagaagc ctggggcctc agtgaaggtt     60

tcctgcaagg ccagcggata caccttcacc agctacaata tgcactgggt gcgacaggcg    120

cctggacaag ggctagagtg gatgggagct atctatcctg gaaatggtga tacatcctac    180

aatcagaagt tcaagggcag ggtcaccatg accagagaca cgtccacgag cacagtctac    240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc ccgaagctac    300

tatagtaact cttactggta cttcgatctc tggggccgcg gcaccctggt cactgtctcc    360

tcggggggcg gtggatcggg cggtggtgga tctgctagcg aaattgtgtt gacacagtct    420

ccagccaccc tgtctttgtc tccaggtgaa agagccaccc tctcctgcag ggccagttcc    480

agtgttagct acattgtttg gtaccaacag aaacctggcc aggcacctag gctcctcatc    540

tatgccccat ccaacctggc ttctggaata ccagccaggt tcagtggcag tggatccggg    600

acagacttca ctctcaccat cagcagtctt gagcctgaag attttgcagt ttattactgt    660

cagcagtgga gttttaaccc tcccacgttc ggccaaggga ccaaggtgga aatcaaa       717


<210>  122
<211>  239
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  122

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Ser Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Ala Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser 
145                 150                 155                 160 


Ser Val Ser Tyr Ile Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
                165                 170                 175     


Arg Leu Leu Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Ile Pro Ala 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser 
    210                 215                 220                 


Phe Asn Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 


<210>  123
<211>  732
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  123
caggtgcagc tggtgcagtc tggtgctgag agcaagaagc ctggggcctc agtgaaggtt     60

tcctgcaagg ccagcggata caccttcacc agctacaata tgcactgggt gcgacaggcg    120

cctggacaag ggctagagtg gatgggagct atctatcctg gaaatggtga tacatcctac    180

aatcagaagt tcaagggcag ggtcaccatg accagagaca cgtccacgag cacagtctac    240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc ccgaagctac    300

tatagtaact cttactggta cttcgatctc tggggccgcg gcaccctggt cactgtctcc    360

tcggggggcg gtggatcggg cggtggtgga tctggaggag gtgggtctgc tagcgaaatt    420

gtgttgacac agtctccagc caccctgtct ttgtctccag gtgaaagagc caccctctcc    480

tgcagggcca gttccagtgt tagctacatt gtttggtacc aacagaaacc tggccaggca    540

cctaggctcc tcatctatgc cccatccaac ctggcttctg gaataccagc caggttcagt    600

ggcagtggat ccgggacaga cttcactctc accatcagca gtcttgagcc tgaagatttt    660

gcagtttatt actgtcagca gtggagtttt aaccctccca cgttcggcca agggaccaag    720

gtggaaatca aa                                                        732


<210>  124
<211>  244
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  124

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Ser Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Glu Ile Val Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile Val Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ala Pro Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  125
<211>  813
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  anti-CD28 (2e12) VLVH (PN)

<400>  125
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcc     60

agaggagtcg acattgtgct cacccaatct ccagcttctt tggctgtgtc tctaggtcag    120

agagccacca tctcctgcag agccagtgaa agtgttgaat attatgtcac aagtttaatg    180

cagtggtacc aacagaaacc aggacagcca cccaaactcc tcatctctgc tgctagcaac    240

gtagaatctg gggtccctgc caggtttagt ggcagtgggt ctgggacaga ctttagcctc    300

aacatccatc ctgtggagga ggatgatatt gcaatgtatt tctgtcagca aagtaggaag    360

gttccatgga cgttcggtgg aggcaccaag ctggaaatca aacggggtgg cggtggatcc    420

ggcggaggtg ggtcgggtgg cggcggatct caggtgcagc tgaaggagtc aggacctggc    480

ctggtggcgc cctcacagag cctgtccatc acatgcaccg tctcagggtt ctcattaacc    540

ggctatggtg taaactgggt tcgccagcct ccaggaaagg gtctggagtg gctgggaatg    600

atatggggtg atggaagcac agactataat tcagctctca aatccagact atcgatcacc    660

aaggacaact ccaagagcca agttttctta aaaatgaaca gtctgcaaac tgatgacaca    720

gccagatact actgtgcccg agatggttat agtaactttc attactatgt tatggactac    780

tggggtcaag gaacctcagt caccgtctcc tct                                 813


<210>  126
<211>  271
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  anti-CD28 (2e12) VLVH (AA)

<220>
<221>  misc_feature
<222>  (1)..(23)
<223>  Leader

<220>
<221>  misc_feature
<222>  (24)..(135)
<223>  VL

<220>
<221>  misc_feature
<222>  (136)..(150)
<223>  Linker

<220>
<221>  misc_feature
<222>  (151)..(271)
<223>  VH

<400>  126

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Val Asp Ile Val Leu Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn 
65                  70                  75                  80  


Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met 
            100                 105                 110         


Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 
145                 150                 155                 160 


Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
                165                 170                 175     


Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp 
        195                 200                 205             


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser 
    210                 215                 220                 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
225                 230                 235                 240 


Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr 
                245                 250                 255     


Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            260                 265                 270     


<210>  127
<211>  828
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  anti-CD28 (2e12) VHVL (PN)

<400>  127
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcc     60

agaggagtcc aggtgcagct gaaggagtca ggacctggcc tggtggcgcc ctcacagagc    120

ctgtccatca catgcaccgt ctcagggttc tcattaaccg gctatggtgt aaactgggtt    180

cgccagcctc caggaaaggg tctggagtgg ctgggaatga tatggggtga tggaagcaca    240

gactataatt cagctctcaa atccagacta tcgatcacca aggacaactc caagagccaa    300

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccagatacta ctgtgcccga    360

gatggttata gtaactttca ttactatgtt atggactact ggggtcaagg aacctcagtc    420

accgtctcct ctgggggtgg aggctctggt ggcggtggat ccggcggagg tgggtcgggt    480

ggcggcggat ctgacattgt gctcacccaa tctccagctt ctttggctgt gtctctaggt    540

cagagagcca ccatctcctg cagagccagt gaaagtgttg aatattatgt cacaagttta    600

atgcagtggt accaacagaa accaggacag ccacccaaac tcctcatctc tgctgctagc    660

aacgtagaat ctggggtccc tgccaggttt agtggcagtg ggtctgggac agactttagc    720

ctcaacatcc atcctgtgga ggaggatgat attgcaatgt atttctgtca gcaaagtagg    780

aaggttccat ggacgttcgg tggaggcacc aagctggaaa tcaaacgt                 828


<210>  128
<211>  276
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  anti-CD28 (2e12) VHVL (AA)

<220>
<221>  misc_feature
<222>  (1)..(23)
<223>  Leader

<220>
<221>  misc_feature
<222>  (24)..(144)
<223>  VH

<220>
<221>  misc_feature
<222>  (145)..(164)
<223>  Linker

<220>
<221>  misc_feature
<222>  (165)..(276)
<223>  VL

<400>  128

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Val Gln Val Gln Leu Lys Glu Ser Gly Pro 
            20                  25                  30          


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 
        35                  40                  45              


Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr 
65                  70                  75                  80  


Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn 
                85                  90                  95      


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
            100                 105                 110         


Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr 
        115                 120                 125             


Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
                165                 170                 175     


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
            180                 185                 190         


Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 
    210                 215                 220                 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
225                 230                 235                 240 


Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys 
                245                 250                 255     


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys Arg 
        275     


<210>  129
<211>  725
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  G-28-1 VLVH (PN)

<400>  129
accggtgaca tccagatgac tcagtctcca gcctccctat ctgcatctgt gggagagact     60

gtcaccatca catgtcgaac aagtgaaaat gtttacagtt atttggcttg gtatcagcag    120

aaacagggaa aatctcctca gctcctggtc tcttttgcaa aaaccttagc agaaggtgtg    180

ccatcaaggt tcagtggcag tggatcaggc acacagtttt ctctgaagat cagcagcctg    240

cagcctgaag attctggaag ttatttctgt caacatcatt ccgataatcc gtggacgttc    300

ggtggaggca ccgaactgga gatcaaaggt ggcggtggct cgggcggtgg tgggtcgggt    360

ggcggcggat ctgctagcgc agtccagctg cagcagtctg gacctgagct ggaaaagcct    420

ggcgcttcag tgaagatttc ctgcaaggct tctggttact cattcactgg ctacaatatg    480

aactgggtga agcagaataa tggaaagagc cttgagtgga ttggaaatat tgatccttat    540

tatggtggta ctacctacaa ccggaagttc aagggcaagg ccacattgac tgtagacaaa    600

tcctccagca cagcctacat gcagctcaag agtctgacat ctgaggactc tgcagtctat    660

tactgtgcaa gatcggtcgg ccctatggac tactggggtc aaggaacctc agtcaccgtc    720

tcgag                                                                725


<210>  130
<211>  239
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  G-28-1 VLVH (AA)

<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  VL

<220>
<221>  misc_feature
<222>  (108)..(124)
<223>  Linker

<220>
<221>  misc_feature
<222>  (125)..(239)
<223>  VH

<400>  130

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Val Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Ser Phe Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ser Gly Ser Tyr Phe Cys Gln His His Ser Asp Asn Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Ala Val Gln Leu 
        115                 120                 125             


Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Lys Ile 
    130                 135                 140                 


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn Trp 
145                 150                 155                 160 


Val Lys Gln Asn Asn Gly Lys Ser Leu Glu Trp Ile Gly Asn Ile Asp 
                165                 170                 175     


Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys Gly Lys Ala 
            180                 185                 190         


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Lys 
        195                 200                 205             


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Val 
    210                 215                 220                 


Gly Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
225                 230                 235                 


<210>  131
<211>  767
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  G28-1 VHVL (PN)

<400>  131
accggtgagg tccagctgca acagtctgga cctgaactgg tgaagcctgg agcttcaatg     60

aagatttcct gcaaggcctc tggttactca ttcactggct acatcgtgaa ctggctgaag    120

cagagccatg gaaagaacct tgagtggatt ggacttatta atccatacaa aggtcttact    180

acctacaacc agaaattcaa gggcaaggcc acattaactg tagacaagtc atccagcaca    240

gcctacatgg agctcctcag tctgacatct gaagactctg cagtctatta ctgtgcaaga    300

tctgggtact atggtgactc ggactggtac ttcgatgtct ggggcgcagg gaccacggtc    360

accgtctcct ctggtggcgg tggctcgggc ggtggtggat ctggaggagg tgggagcggg    420

ggaggtggca gtgctagcga catccagatg acacagacta catcctccct gtctgcctct    480

ctgggagaca gagtcaccat cagttgcagg gcaagtcagg acattcgcaa ttatttaaac    540

tggtatcagc agaaaccaga tggaactgtt aaactcctga tctactacac atcaagatta    600

cactcaggag tcccatcaag gttcagtggc agtgggtctg gaacagatta ttctctcacc    660

attgccaacc tgcaaccaga agatattgcc acttactttt gccaacaggg taatacgctt    720

ccgtggacgt tcggtggagg caccaaactg gtaaccaaac gctcgag                  767


<210>  132
<211>  253
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  G28-1 VHVL (AA)

<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  VH

<220>
<221>  misc_feature
<222>  (122)..(144)
<223>  Linker

<220>
<221>  misc_feature
<222>  (145)..(253)
<223>  VL

<400>  132

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Ile Val Asn Trp Leu Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Leu Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser 
    130                 135                 140                 


Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
145                 150                 155                 160 


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
                165                 170                 175     


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
            180                 185                 190         


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ala Asn Leu Gln Pro 
    210                 215                 220                 


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Leu Val Thr Lys Arg Ser 
                245                 250             


<210>  133
<211>  749
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  G-19-4 VLVH (PN)

<400>  133
accggtgaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga     60

gtcaccatca gttgcagggc aagtcaggac attcgcaatt atttaaactg gtatcagcag    120

aaaccagatg gaactgttaa actcctgatc tactacacat caagattaca ctcaggagtc    180

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tgccaacctg    240

caaccagaag atattgccac ttacttttgc caacagggta atacgcttcc gtggacgttc    300

ggtggaggca ccaaactggt aaccaaacgg ggtggcggtg gctcgggcgg tggtggatct    360

ggaggaggtg ggagcgctag cgaggtccag ctgcaacagt ctggacctga actggtgaag    420

cctggagctt caatgaagat ttcctgcaag gcctctggtt actcattcac tggctacatc    480

gtgaactggc tgaagcagag ccatggaaag aaccttgagt ggattggact tattaatcca    540

tacaaaggtc ttactaccta caaccagaaa ttcaagggca aggccacatt aactgtagac    600

aagtcatcca gcacagccta catggagctc ctcagtctga catctgaaga ctctgcagtc    660

tattactgtg caagatctgg gtactatggt gactcggact ggtacttcga tgtctggggc    720

gcagggacca cggtcaccgt ctcctcgag                                      749


<210>  134
<211>  247
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  G-19-4 VLVH (AA)

<220>
<221>  misc_feature
<222>  (1)..(108)
<223>  VL

<220>
<221>  misc_feature
<222>  (109)..(125)
<223>  Linker

<220>
<221>  misc_feature
<222>  (126)..(247)
<223>  VH

<400>  134

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ala Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Val Thr Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Glu Val Gln 
        115                 120                 125             


Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys 
    130                 135                 140                 


Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Ile Val Asn 
145                 150                 155                 160 


Trp Leu Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile Gly Leu Ile 
                165                 170                 175     


Asn Pro Tyr Lys Gly Leu Thr Thr Tyr Asn Gln Lys Phe Lys Gly Lys 
            180                 185                 190         


Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu 
        195                 200                 205             


Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser 
    210                 215                 220                 


Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly 
225                 230                 235                 240 


Thr Thr Val Thr Val Ser Ser 
                245         


<210>  135
<211>  752
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  G19-4 VHVL (PN)

<400>  135
accggtgagg tccagctgca acagtctgga cctgaactgg tgaagcctgg agcttcaatg     60

aagatttcct gcaaggcctc tggttactca ttcactggct acatcgtgaa ctggctgaag    120

cagagccatg gaaagaacct tgagtggatt ggacttatta atccatacaa aggtcttact    180

acctacaacc agaaattcaa gggcaaggcc acattaactg tagacaagtc atccagcaca    240

gcctacatgg agctcctcag tctgacatct gaagactctg cagtctatta ctgtgcaaga    300

tctgggtact atggtgactc ggactggtac ttcgatgtct ggggcgcagg gaccacggtc    360

accgtctcct ctggtggcgg tggctcgggc ggtggtggat ctggaggagg tgggagcgct    420

agcgacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc    480

accatcagtt gcagggcaag tcaggacatt cgcaattatt taaactggta tcagcagaaa    540

ccagatggaa ctgttaaact cctgatctac tacacatcaa gattacactc aggagtccca    600

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattgc caacctgcaa    660

ccagaagata ttgccactta cttttgccaa cagggtaata cgcttccgtg gacgttcggt    720

ggaggcacca aactggtaac caaacgctcg ag                                  752


<210>  136
<211>  248
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  G19-4 VHVL (AA)

<220>
<221>  misc_feature
<222>  (1)..(122)
<223>  VH

<220>
<221>  misc_feature
<222>  (123)..(139)
<223>  Linker

<220>
<221>  misc_feature
<222>  (140)..(248)
<223>  VL

<400>  136

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Ile Val Asn Trp Leu Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Leu Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg 
            180                 185                 190         


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Tyr Ser Leu Thr Ile Ala Asn Leu Gln Pro Glu Asp Ile Ala Thr 
    210                 215                 220                 


Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Val Thr Lys Arg Ser 
                245             


<210>  137
<211>  744
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucloetide

<400>  137
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt     60

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg    120

cccgggaaag gcctcgagtg gatgggcaat attgatcctt attatggtgg tactacctac    180

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac    240

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc    300

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctctgg gggtggaggc    360

tctggtggcg gtggctctgg cggaggtgga tccggtggcg gcggatctgg cgggggtggc    420

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc    480

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa    540

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggaattcca    600

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag    660

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc    720

caagggacca aggtggaaat caaa                                           744


<210>  138
<211>  248
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  138

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  139
<211>  654
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  hIgG1 CH2CH3 (PN)

<400>  139
gcacctgaac tcctgggtgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc     60

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac    120

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag    180

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac    240

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc    300

cccatcgaga aaacaatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc    360

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa    420

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac    480

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc    540

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag    600

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga          654


<210>  140
<211>  217
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  hIgG1 CH2CH3 (AA)

<400>  140

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  141
<211>  654
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  141
gcacctgaac tcctgggtgg atcgtcagtc ttcctcttcc ccccaaaacc caaggacacc     60

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac    120

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag    180

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac    240

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc    300

cccatcgaga aaacaatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc    360

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa    420

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac    480

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc    540

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag    600

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga          654


<210>  142
<211>  217
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  142

Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  143
<211>  654
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  143
gcacctgaac tcctgggtgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc     60

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac    120

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag    180

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac    240

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc    300

tccatcgaga aaacaatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc    360

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa    420

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac    480

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc    540

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag    600

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga          654


<210>  144
<211>  217
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  hIgG1 (P331S) CH2CH3 (AA)

<220>
<221>  misc_feature
<223>  Position 101 corresponds to position 331 (Kabat)

<400>  144

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  145
<211>  654
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  hIgG1 (P238S/P331S) CH2CH3 (PN)

<400>  145
gcacctgaac tcctgggtgg atcgtcagtc ttcctcttcc ccccaaaacc caaggacacc     60

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac    120

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag    180

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac    240

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc    300

tccatcgaga aaacaatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc    360

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa    420

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac    480

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc    540

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag    600

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga          654


<210>  146
<211>  217
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  hIgG1 (P238S/P331S) CH2CH3 (AA)

<220>
<221>  misc_feature
<223>  Position 8 corresponds to position 238 (Kabat)

       Position 101 corresponds to position 331 (Kabat)

<400>  146

Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  147
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker STD1 (PN)

<400>  147
aattatggtg gcggtggctc gggcggtggt ggatctggag gaggtgggag tgggaattct     60


<210>  148
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker STD1 (AA)

<400>  148

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Ser 
            20  


<210>  149
<211>  114
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  Linker STD2 (PN)

<400>  149
aattatggtg gcggtggctc gggcggtggt ggatctggag gaggtgggag tgggaattat     60

ggtggcggtg gctcgggcgg tggtggatct ggaggaggtg ggagtgggaa ttct          114


<210>  150
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker STD2 (AA)

<400>  150

Asn Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Asn Ser 
        35                  


<210>  151
<211>  6
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H1 (PN)

<400>  151
aattct                                                                 6


<210>  152
<211>  2
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  152

Asn Ser 
1       


<210>  153
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H2 (PN)

<400>  153
ggtggcggtg gctcggggaa ttct                                            24


<210>  154
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  154

Gly Gly Gly Gly Ser Gly Asn Ser 
1               5               


<210>  155
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H3 (PN)

<400>  155
aattatggtg gcggtggctc tgggaattct                                      30


<210>  156
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H3 (AA)

<400>  156

Asn Tyr Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10  


<210>  157
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H4 (PN)

<400>  157
ggtggcggtg gctcgggcgg tggtggatct gggaattct                            39


<210>  158
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H4 (AA)

<400>  158

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10              


<210>  159
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H5 (PN)

<400>  159
aattatggtg gcggtggctc gggcggtggt ggatctggga attct                     45


<210>  160
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H5 (AA)

<400>  160

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10                  15  


<210>  161
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H6 (PN)

<400>  161
ggtggcggtg gctcgggcgg tggtggatct gggggaggag gcagcgggaa ttct           54


<210>  162
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  162

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Asn Ser 
        


<210>  163
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H7 (PN)

<400>  163
gggtgtccac cttgtccgaa ttct                                            24


<210>  164
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Syntehetic peptide


<220>
<221>  misc_feature
<223>  Linker H7 (AA)

<400>  164

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  165
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H8 (PN)

<400>  165
gggtctccac cttctccgaa ttct                                            24


<210>  166
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  166

Gly Ser Pro Pro Ser Pro Asn Ser 
1               5               


<210>  167
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H9a (PN)

<400>  167
tctccacctt ctccgaattc t                                               21


<210>  168
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H9a (AA)

<400>  168

Ser Pro Pro Ser Pro Asn Ser 
1               5           


<210>  169

<400>  169
000

<210>  170

<400>  170
000

<210>  171
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H11a (PN)

<400>  171
gagcccacat ctaccgacaa aactcacaca tctccaccca gcccgaattc t              51


<210>  172
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H11a (AA)

<400>  172

Glu Pro Thr Ser Thr Asp Lys Thr His Thr Ser Pro Pro Ser Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  173
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H12a (PN)

<400>  173
gagcccacat ctaccgacaa aactcacaca tctccaccca gcccgaattc t              51


<210>  174
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H12a (AA)

<400>  174

Glu Pro Thr Ser Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  175
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker  H13 (PN)

<400>  175
gagcccacat ctaccgacaa aactcacaca tctccaccca gcccgaattc t              51


<210>  176
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H13 (AA)

<400>  176

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  177

<400>  177
000

<210>  178

<400>  178
000

<210>  179
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H15 (PN)

<400>  179
ggcggtggtg gctcctgtcc accttgtccg aattct                               36


<210>  180
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H15 (AA)

<400>  180

Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Asn Ser 
1               5                   10          


<210>  181
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H16 (PN)

<400>  181
ctgtctgtga aagctgactt cctcactcca tccatcggga attct                     45


<210>  182
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H16 (AA)

<400>  182

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10                  15  


<210>  183
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H17 (PN)

<400>  183
ctgtctgtga aagctgactt cctcactcca tccatctcct gtccaccttg cccgaattct     60


<210>  184
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H17 (AA)

<400>  184

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  185
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker  H18 (PN)

<400>  185
ctgtctgtgc tcgctaactt cagtcagcca gagatcggga attct                     45


<210>  186
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H18 (AA)

<400>  186

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  187
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H19 (PN)

<400>  187
ctgtctgtgc tcgctaactt cagtcagcca gagatctcct gtccaccttg cccgaattct     60


<210>  188
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H19 (AA)

<400>  188

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  189
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H20 (PN)

<400>  189
ctgaaaatcc aggagagggt cagtaagcca aagatctcga attct                     45


<210>  190
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H20 (AA)

<400>  190

Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Asn Ser 
1               5                   10                  15  


<210>  191
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Linker H21 (PN)

<400>  191
ctgaaaatcc aggagagggt cagtaagcca aagatctcct gtccaccttg cccgaattct     60


<210>  192
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H21 (AA)

<400>  192

Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  193
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Linker H22 (PN)

<400>  193
ctggatgtga gtgagaggcc ttttcctcca cacatccaga attct                     45


<210>  194
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H22 (AA)

<400>  194

Leu Asp Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Asn Ser 
1               5                   10                  15  


<210>  195
<211>  63
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker  H23 (PN)

<400>  195
ctggatgtga gtgagaggcc ttttcctcca cacatccagt cctgtccacc ttgcccgaat     60

tct                                                                   63


<210>  196
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H23 (AA)

<400>  196

Leu Asp Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Ser Cys Pro 
1               5                   10                  15      


Pro Cys Pro Asn Ser 
            20      


<210>  197
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  197
cgggaacagc tggcagaggt cactttgagc ttgaaagcga attct                     45


<210>  198
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H24 (AA)

<400>  198

Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Asn Ser 
1               5                   10                  15  


<210>  199
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H25 (PN)

<400>  199
cgggaacagc tggcagaggt cactttgagc gtgaaagctt gtccaccctg cccgaattct     60


<210>  200
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H25 (AA)

<400>  200

Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  201
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H26 (PN)

<400>  201
cggattcacc agatgaactc cgagttgagc gtgctcgcga attct                     45


<210>  202
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H26 (AA)

<400>  202

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10                  15  


<210>  203
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H27 (PN)

<400>  203
cggattcacc agatgaactc cgagttgagc gtgctcgctt gtccaccctg cccgaattct     60


<210>  204
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H27 (AA)

<400>  204

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  205
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker  H28 (PN)

<400>  205
gataccaaag ggaagaacgt cctcgagaag atcttctcga attct                     45


<210>  206
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H28 (AA)

<400>  206

Asp Thr Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Ser Asn Ser 
1               5                   10                  15  


<210>  207
<211>  63
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H29 (PN)

<400>  207
gataccaaag ggaagaacgt cctcgagaag atcttcgact cctgtccacc ttgcccgaat     60

tct                                                                   63


<210>  208
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H29 (AA)

<400>  208

Asp Thr Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Ser Cys Pro 
1               5                   10                  15      


Pro Cys Pro Asn Ser 
            20      


<210>  209
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H30 (PN)

<400>  209
ctgccacctg agacacagga gagtcaagaa gtcaccctga attct                     45


<210>  210
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H30 (AA)

<400>  210

Leu Pro Pro Glu Thr Gln Glu Ser Gln Glu Val Thr Leu Asn Ser 
1               5                   10                  15  


<210>  211
<211>  63
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H31 (PN)

<400>  211
ctgccacctg agacacagga gagtcaagaa gtcaccctgt cctgtccacc ttgcccgaat     60

tct                                                                   63


<210>  212
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H31 (AA)

<400>  212

Leu Pro Pro Glu Thr Gln Glu Ser Gln Glu Val Thr Leu Ser Cys Pro 
1               5                   10                  15      


Pro Cys Pro Asn Ser 
            20      


<210>  213
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H32 (PN)

<400>  213
cggattcacc tgaacgtgtc cgagaggccc tttcctccga attct                     45


<210>  214
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H32 (AA)

<400>  214

Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 
1               5                   10                  15  


<210>  215
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker  H33 (PN)

<400>  215
cggattcacc tgaacgtgtc cgagaggccc tttcctccct gtccaccctg cccgaattct     60


<210>  216
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H33 (AA)

<400>  216

Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  217

<400>  217
000

<210>  218

<400>  218
000

<210>  219

<400>  219
000

<210>  220

<400>  220
000

<210>  221
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H36 (PN)

<400>  221
gggtgtccac cttgtccagg cggtggtgga tcgaattct                            39


<210>  222
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H36 (AA)

<400>  222

Gly Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Asn Ser 
1               5                   10              


<210>  223

<400>  223
000

<210>  224

<400>  224
000

<210>  225

<400>  225
000

<210>  226

<400>  226
000

<210>  227

<400>  227
000

<210>  228

<400>  228
000

<210>  229
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H40 (PN)

<400>  229
ggatgtccac cttgtcccgc gaattct                                         27


<210>  230
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H40 (AA)

<400>  230

Gly Cys Pro Pro Cys Pro Ala Asn Ser 
1               5                   


<210>  231

<400>  231
000

<210>  232

<400>  232
000

<210>  233

<400>  233
000

<210>  234

<400>  234
000

<210>  235

<400>  235
000

<210>  236

<400>  236
000

<210>  237
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H44 (PN)

<400>  237
ggaggagcta gttgtccacc ttgtcccggg aattct                               36


<210>  238
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H44 (AA)

<400>  238

Gly Gly Ala Ser Cys Pro Pro Cys Pro Gly Asn Ser 
1               5                   10          


<210>  239
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H45 (PN)

<400>  239
ggaggagcca gttgtccacc ttgtgccggg aattct                               36


<210>  240
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H45 (AA)

<400>  240

Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser 
1               5                   10          


<210>  241
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker H46 (PN)

<400>  241
ggaggagcca gttgtccacc ttgtgcgaat tct                                  33


<210>  242
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker H46 (AA)

<400>  242

Gly Gly Ala Ser Cys Pro Pro Cys Ala Asn Ser 
1               5                   10      


<210>  243
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker (G4S)2AS (AA)

<400>  243

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser 
1               5                   10          


<210>  244
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker (G4S)3 (PN)

<400>  244
ggtggcggtg gatccggcgg aggtgggtcg ggtggcggcg gatct                     45


<210>  245
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker (G4S)3 (AA)

<400>  245

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  246
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Linker (G4S)4 (PN)

<400>  246
ggtggcggtg gctcgggcgg tggtggatct ggaggaggtg ggagcggggg aggtggcagt     60


<210>  247
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker (G4S)4 (AA)

<400>  247

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser 
    


<210>  248
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<223>  Linker (G4S)4AS (AA)

<400>  248

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Ala Ser 
            20          


<210>  249
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Anti CD28 antibody leader peptide (AA)

<400>  249

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly 
            20          


<210>  250
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  VK3 leader peptide (AA)

<400>  250

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  251
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Heavy Chain GSP1 primer

<400>  251
aggtgctgga ggggacagtc actgagctgc                                      30


<210>  252
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  252

Gly Thr Cys Ala Cys Trp Gly Thr Cys Ala Cys Thr Gly Arg Cys Thr 
1               5                   10                  15      


Cys Ala Gly Gly Gly Ala Ala Arg Thr Ala Gly Cys 
            20                  25              


<210>  253
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Light chain GSP1 primer

<400>  253
gggtgctgct catgctgtag gtgctgtctt tgc                                  33


<210>  254
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Nested light chain GSP2 primer

<400>  254
caagaagcac acgactgagg cacctccaga tg                                   32


<210>  255
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  5' RACE abridged anchor primer

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  n is a, c, g or t

<400>  255
ggccacgcgt cgactagtac gggnngggnn gggnng                               36


<210>  256
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  T7 sequencing primer

<400>  256
gtaatacgac tcactatagg                                                 20


<210>  257
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primre


<220>
<221>  misc_feature
<223>  M13 reverse primer

<400>  257
caggaaacag ctatgacc                                                   18


<210>  258
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer hVK3L-F3H3

<400>  258
gcgataaagc ttgccgccat ggaagcacca gcgcagcttc tcttcc                    46


<210>  259
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer hVK3L-F2

<400>  259
accagcgcag cttctcttcc tcctgctact ctggctccca gataccaccg                50


<210>  260
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer hVK3L-F1-2H7VL

<400>  260
ggctcccaga taccaccggt caaattgttc tctcccagtc tccag                     45


<210>  261
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer2H7VH-NheF

<400>  261
gcgatagcta gccaggctta tctacagcag tctgg                                35


<210>  262
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer G4S-NheR

<400>  262
gcgatagcta gccccacctc ctccagatcc accaccgccc gag                       43


<210>  263
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer 015VH-XhoR

<400>  263
gcgtactcga ggagacggtg accgtggtcc ctgtg                                35


<210>  264

<400>  264
000

<210>  265
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer G1H-S-XHO

<400>  265
gcagtctcga gcgagcccaa atcttctgac aaaactc                              37


<210>  266
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer CH3R-EcoR1

<400>  266
gcgtgagaat tcttacccgg agacagggag aggctc                               36


<210>  267
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer G1-XBA-R

<400>  267
gcgacgtcta gagtcattta cccggagaca gg                                   32


<210>  268
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer G4SLinkR1-S

<400>  268
aattatggtg gcggtggctc gggcggtggt ggatctggag gaggtgggag tggg           54


<210>  269
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer G4SLinkR1-AS

<400>  269
aattcccact cccacctcct ccagatccac caccgcccga gccaccgcca ccat           54


<210>  270
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer 2E12VLXbaR

<400>  270
gcgtgtctag attaacgttt gatttccagc ttggtg                               36


<210>  271
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer 2E12VLR1F

<400>  271
gcgatgaatt ctgacattgt gctcacccaa tctcc                                35


<210>  272
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer 2E12VHR1F

<400>  272
gcgatgaatt ctcaggtgca gctgaaggag tcag                                 34


<210>  273
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer 2E12VHXbaR

<400>  273
gcgagtctag attaagagga gacggtgact gaggttc                              37


<210>  274
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer 2e12VHdXbaF1

<400>  274
gggtctggag tggctgggaa tgatatg                                         27


<210>  275
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer 2e12VHdXbaR1

<400>  275
attcccagcc actccagacc ctttcctg                                        28


<210>  276
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer IgBsrG1F

<400>  276
gagaaccaca ggtgtacacc ctg                                             23


<210>  277
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer IgBsrG1R

<400>  277
gcagggtgta cacctgtggt tctcg                                           25


<210>  278
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer M13R

<400>  278
caggaaacag ctatgac                                                    17


<210>  279
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer M13F

<400>  279
gtaaaacgac ggccagtg                                                   18


<210>  280
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer T7

<400>  280
gtaatacgac tcactatagg                                                 20


<210>  281
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer pD18F-17

<400>  281
aactagagaa cccactg                                                    17


<210>  282
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer pD18F-20

<400>  282
gctaactaga gaacccactg                                                 20


<210>  283
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer pD18F-1

<400>  283
atacgactca ctataggg                                                   18


<210>  284
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer pD18R-s

<400>  284
gctctagcat ttaggtgac                                                  19


<210>  285
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer CH3seqF1

<400>  285
catgaggctc tgcacaac                                                   18


<210>  286
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer CH3seqF2

<400>  286
cctctacagc aagctcac                                                   18


<210>  287
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer CH3seqR1

<400>  287
ggttcttggt cagctcatc                                                  19


<210>  288
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer CH3seqR2

<400>  288
gtgagcttgc tgtagagg                                                   18


<210>  289
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer CH3seqR2

<400>  289
gcgatagaat tcccagatcc accaccgccc gagccaccgc caccataatt c              51


<210>  290
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer L1-6R

<400>  290
gcgatagaat tcccagagcc accgccacca taattc                               36


<210>  291
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer L3R

<400>  291
gcgtatgaat tccccgagcc accgccaccc ttacccggag acagg                     45


<210>  292
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer L4R

<400>  292
gcgtatgaat tcccagatcc accaccgccc gagccaccgc cacccttac                 49


<210>  293
<211>  44
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer L5R

<400>  293
gcgtatgaat tcccgctgcc tcctccccca gatccaccac cgcc                      44


<210>  294
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer IgBsrG1F

<400>  294
gagaaccaca ggtgtacacc ctg                                             23


<210>  295
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  PCR primer L-CPPCPR

<400>  295
gcgatagaat tcggacaagg tggacacccc ttacccggag acagggagag                50


<210>  296
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  W0001F PCR primer (PN)

<400>  296
agataccacc ggttcctcga gcgagcccaa atcttctgac                           40


<210>  297
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  W0002F PCR primer

<400>  297
agataccacc ggttcctcga gagagcccaa atcttctgac                           40


<210>  298
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  W0003F PCR primer

<400>  298
agataccacc ggtgcctcga gcgagcccaa atcttctgac                           40


<210>  299
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  W0004F PCR primer

<400>  299
agataccacc ggtgcctcga gagagcccaa atcttctgac                           40


<210>  300
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  W0005F PCR primer

<400>  300
agataccacc ggtacctcga gcgagcccaa atcttctgac                           40


<210>  301
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  W0006F PCR primer

<400>  301
agataccacc ggtacctcga gagagcccaa atcttctgac                           40


<210>  302
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  W0007F PCR primer

<400>  302
agataccacc ggttctctcg agcccaaatc ttctgac                              37


<210>  303
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  W0008F PCR primer

<400>  303
agataccacc ggtcagctcg agcccaaatc ttctgac                              37


<210>  304
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primre


<220>
<221>  misc_feature
<223>  W0009F PCR primer

<400>  304
agataccacc ggtgatctcg agcccaaatc ttctgac                              37


<210>  305
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  W0010F PCR primer

<400>  305
agataccacc ggtgaactcg agcccaaatc ttctgac                              37


<210>  306
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  W0011F PCR primer

<400>  306
agataccacc ggtgctctcg agcccaaatc ttctgac                              37


<210>  307
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  W0012F PCR primer

<400>  307
agataccacc ggtactctcg agcccaaatc ttctgac                              37


<210>  308
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  12 HL XbaR PCR primer

<400>  308
gcgatatcta gattaacgtt tgatttccag cttggtg                              37


<210>  309
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD37 binding domain primer G281LH-NheR

<400>  309
actgctgcag ctggaccgcg ctagctccgc cgccacccga c                         41


<210>  310
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD37 binding domain primer G281LH-NheF

<400>  310
ggcggagcta gcgcggtcca gctgcagcag tctggacctg                           40


<210>  311
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD37 binding domain primer G281-LH-LPinF

<400>  311
gcgatcaccg gtgacatcca gatgactcag tctccag                              37


<210>  312
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD37 binding domain primer G281-LH-HXhoR

<400>  312
gcgatactcg aggagacggt gactgaggtt ccttgac                              37


<210>  313
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD37 binding domain primer G281-LH-LEcoF

<400>  313
gcgatcgaat tcagacatcc agatgactca gtctccag                             38


<210>  314
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD37 binding domain primer G281-LH-HXbaR

<400>  314
gcgattctag attaggaaga gacggtgact gaggttcctt gac                       43


<210>  315
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD37 binding domain primer G281-HL-HF

<400>  315
gcgataaccg gtgcggtcca gctgcagcag tctggac                              37


<210>  316
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD37 binding domain primer G281-HL-HR3

<400>  316
gacccaccac cgcccgagcc accgccacca gaagagacgg tgactgaggt tc             52


<210>  317
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD37 binding domain primer G281-HL-HR2

<400>  317
actcccgcct cctcctgatc cgccgccacc cgacccacca ccgcccgag                 49


<210>  318
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD37 binding domain primer G281-HL-HNheR

<400>  318
gagtcatctg gatgtcgcta gcactcccgc ctcctcctga tc                        42


<210>  319
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD37 binding domain primer G281-HL-LNheF

<400>  319
atcaggagga ggcgggagtg ctagcgacat ccagatgact cagtc                     45


<210>  320
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD37 binding domain primer G281-HL-LXhoR

<400>  320
gcgatactcg agcctttgat ctccagttcg gtgcctc                              37


<210>  321
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD37 binding domain primer G281-HL-LXbaR

<400>  321
gcgatatcta gactcaacct ttgatctcca gttcggtgcc tc                        42


<210>  322
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD37 binding domain primer G281-HL-EcoF

<400>  322
gcgatagaat tcgcggtcca gctgcagcag tctggac                              37


<210>  323
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LH-LF1

<400>  323
gcgtatgaac cggtgacatc cagatgacac agactacatc                           40


<210>  324
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LF2

<400>  324
atccagatga cacagactac atcctccctg tctgcctctc tgggagacag                50


<210>  325
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LF3

<400>  325
gtctgcctct ctgggagaca gagtcaccat cagttgcagg gcaagtcagg ac             52


<210>  326
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LF4

<400>  326
gttgcagggc aagtcaggac attcgcaatt atttaaactg gtatcagcag                50


<210>  327
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LF5

<400>  327
atttaaactg gtatcagcag aaaccagatg gaactgttaa actcctgatc                50


<210>  328
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LF6

<400>  328
gaactgttaa actcctgatc tactacacat caagattaca ctcaggagtc                50


<210>  329
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LF7

<400>  329
caagattaca ctcaggagtc ccatcaaggt tcagtggcag tgggtctgga ac             52


<210>  330
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LR7

<400>  330
caggttggca atggtgagag aataatctgt tccagaccca ctgccactga ac             52


<210>  331
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LR6

<400>  331
gcaaaagtaa gtggcaatat cttctggttg caggttggca atggtgagag                50


<210>  332
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LR5

<400>  332
gaacgtccac ggaagcgtat taccctgttg gcaaaagtaa gtggcaatat c              51


<210>  333
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LR4

<400>  333
cgtttggtta ccagtttggt gcctccaccg aacgtccacg gaagcgtatt ac             52


<210>  334
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LR3

<400>  334
accaccgccc gagccaccgc caccccgttt ggttaccagt ttggtg                    46


<210>  335
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primre


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LR2

<400>  335
gctagcgctc ccacctcctc cagatccacc accgcccgag ccaccgccac                50


<210>  336
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LH-LR1

<400>  336
gttgcagctg gacctcgcta gcgctcccac ctcctccaga tc                        42


<210>  337
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LH-HF1

<400>  337
gatctggagg aggtgggagc gctagcgagg tccagctgca acagtctgga cctg           54


<210>  338
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-HF2

<400>  338
agctgcaaca gtctggacct gaactggtga agcctggagc ttcaatgaag                50


<210>  339
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-HF3

<400>  339
agcctggagc ttcaatgaag atttcctgca aggcctctgg ttactcattc                50


<210>  340
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-HF4

<400>  340
gcaaggcctc tggttactca ttcactggct acatcgtgaa ctggctgaag cag            53


<210>  341
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-HF5

<400>  341
atcgtgaact ggctgaagca gagccatgga aagaaccttg agtggattgg ac             52


<210>  342
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-HF6

<400>  342
gaaccttgag tggattggac ttattaatcc atacaaaggt cttactacct ac             52


<210>  343
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-HR6

<400>  343
aatgtggcct tgcccttgaa tttctggttg taggtagtaa gacctttgta tg             52


<210>  344
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-HR5

<400>  344
catgtaggct gtgctggatg acttgtctac agttaatgtg gccttgccct tg             52


<210>  345
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-HR4

<400>  345
actgcagagt cttcagatgt cagactgagg agctccatgt aggctgtgct ggatg          55


<210>  346
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-HR3

<400>  346
accatagtac ccagatcttg cacagtaata gactgcagag tcttcagatg tc             52


<210>  347
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-HR2

<400>  347
gcgccccaga catcgaagta ccagtccgag tcaccatagt acccagatct tg             52


<210>  348
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LH-HR1

<400>  348
gcgaatactc gaggagacgg tgaccgtggt ccctgcgccc cagacatcga ag             52


<210>  349
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-HL-HF1

<400>  349
gcgtatgaac cggtgaggtc cagctgcaac agtctggacc tg                        42


<210>  350
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-HL-HR1

<400>  350
accgccacca gaggagacgg tgaccgtggt ccctgcgccc cagacatcga agtac          55


<210>  351
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-HL-HR0

<400>  351
acctcctcca gatccaccac cgcccgagcc accgccacca gaggagacgg tg             52


<210>  352
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-HL-LF1

<400>  352
gcgggggagg tggcagtgct agcgacatcc agatgacaca gactacatc                 49


<210>  353
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-HL-LR3Xho

<400>  353
gcgaatactc gagcgtttgg ttaccagttt ggtg                                 34


<210>  354
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-HL-LR3Xba

<400>  354
gcgatatcta gattaccgtt tggttaccag tttggtg                              37


<210>  355
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-HL-HF1R1

<400>  355
gcgtatgaga attcagaggt ccagctgcaa cagtctggac ctg                       43


<210>  356
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LH-LF1R1

<400>  356
gcgtatgaga attctgacat ccagatgaca cagactacat c                         41


<210>  357
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<223>  CD3 binding domain primer (G19-4 temp.) 194-LH-HR1Xba

<400>  357
gcgtatgaga attctgacat ccagatgaca cagactacat c                         41


<210>  358
<211>  1551
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  PIMS - W0001 (PN)

<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  Human VK3 leader

<220>
<221>  misc_feature
<222>  (61)..(69)
<223>  Leader-hinge junctions

<220>
<221>  misc_feature
<222>  (70)..(114)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (115)..(765)
<223>  CH2CH3 region

<220>
<221>  misc_feature
<222>  (766)..(789)
<223>  Linker peptide

<220>
<221>  misc_feature
<222>  (790)..(1551)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (1153)..(1212)
<223>  Binding region linker

<400>  358
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt     60

gcctcgagcg agcccaaatc ttgtgacaaa actcacacat gtccaccgtg cccagcacct    120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg    180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag    240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg    300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac    360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc    420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc    480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc    540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag    600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg    660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg    720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaagggtg tccaccttgt    780

ccgaattctc aggtgcagct gaaggagtca gggcctggca gcgtggcgcc ctcacagagc    840

ctgtccatca catgcaccgt ctcagggttc tcattaaccg gctatggtgt aaactgggtt    900

cgccagcctc caggaaaggg tctggagtgg ctgggaatga tatggggtga tggaagcaca    960

gactataatt cagctctcaa atccagacta tcgatcacca aggacaactc caagagccaa   1020

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccagatacta ctgtgctcga   1080

gatggttata gtaactttca ttactatgtt atggactact ggggtcaagg aacctcagtc   1140

accgtctcct ctgggggtgg aggctctggt ggcggtggat ccggcggagg tgggtcgggt   1200

ggcggcggat ctgacattgt gctcacccaa tctccagctt ctttggctgt gtctctaggt   1260

cagagagcca ccatctcctg cagagccagt gaaagtgttg aatattatgt cacaagttta   1320

atgcagtggt accaacagaa accaggacag ccacccaagc tcctcatctc tgctgctagc   1380

aacgtagaat ctggggtccc tgccaggttt agtggcagtg ggtctgggac agactttagc   1440

ctcaacatcc atcctgtgga ggaggatgat attgcaatgt atttctgtca gcaaagtagg   1500

aaggttccat ggacgttcgg tggaggcacc aagctggaaa tcaaacgtta a            1551


<210>  359
<211>  516
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  PIMS - W0001 (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  VK3 leader

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  Leader-hinge junction

<220>
<221>  misc_feature
<222>  (24)..(38)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  misc_feature
<222>  (264)..(516)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (385)..(404)
<223>  Binding region linker

<400>  359

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro 
            260                 265                 270         


Gly Ser Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 
        275                 280                 285             


Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr 
305                 310                 315                 320 


Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn 
                325                 330                 335     


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
            340                 345                 350         


Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr 
        355                 360                 365             


Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
                405                 410                 415     


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
            420                 425                 430         


Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
        435                 440                 445             


Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 
    450                 455                 460                 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
465                 470                 475                 480 


Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys 
                485                 490                 495     


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            500                 505                 510         


Glu Ile Lys Arg 
        515     


<210>  360
<211>  1551
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  PIMS - W0002 (PN)

<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  Human VK3 leader

<220>
<221>  misc_feature
<222>  (61)..(69)
<223>  Leader-hinger junction

<220>
<221>  misc_feature
<222>  (70)..(114)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (115)..(765)
<223>  CH2CH3 region

<220>
<221>  misc_feature
<222>  (766)..(789)
<223>  Linker peptide

<220>
<221>  misc_feature
<222>  (790)..(1551)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (1153)..(1212)
<223>  Binding region linker

<400>  360
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt     60

tcctcgagag agcccaaatc ttgtgacaaa actcacacat gtccaccgtg cccagcacct    120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg    180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag    240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg    300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac    360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc    420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc    480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc    540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag    600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg    660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg    720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaagggtg tccaccttgt    780

ccgaattctc aggtgcagct gaaggagtca gggcctggca gcgtggcgcc ctcacagagc    840

ctgtccatca catgcaccgt ctcagggttc tcattaaccg gctatggtgt aaactgggtt    900

cgccagcctc caggaaaggg tctggagtgg ctgggaatga tatggggtga tggaagcaca    960

gactataatt cagctctcaa atccagacta tcgatcacca aggacaactc caagagccaa   1020

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccagatacta ctgtgctcga   1080

gatggttata gtaactttca ttactatgtt atggactact ggggtcaagg aacctcagtc   1140

accgtctcct ctgggggtgg aggctctggt ggcggtggat ccggcggagg tgggtcgggt   1200

ggcggcggat ctgacattgt gctcacccaa tctccagctt ctttggctgt gtctctaggt   1260

cagagagcca ccatctcctg cagagccagt gaaagtgttg aatattatgt cacaagttta   1320

atgcagtggt accaacagaa accaggacag ccacccaagc tcctcatctc tgctgctagc   1380

aacgtagaat ctggggtccc tgccaggttt agtggcagtg ggtctgggac agactttagc   1440

ctcaacatcc atcctgtgga ggaggatgat attgcaatgt atttctgtca gcaaagtagg   1500

aaggttccat ggacgttcgg tggaggcacc aagctggaaa tcaaacgtta a            1551


<210>  361
<211>  516
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  PIMS - W0002 (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Human VK3 leader

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  Leader-hinge junction

<220>
<221>  misc_feature
<222>  (24)..(38)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  misc_feature
<222>  (256)..(262)
<223>  Linker peptide

<220>
<221>  misc_feature
<222>  (263)..(516)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (385)..(404)
<223>  Binding region linker

<400>  361

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Arg Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro 
            260                 265                 270         


Gly Ser Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 
        275                 280                 285             


Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr 
305                 310                 315                 320 


Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn 
                325                 330                 335     


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
            340                 345                 350         


Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr 
        355                 360                 365             


Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
                405                 410                 415     


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
            420                 425                 430         


Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
        435                 440                 445             


Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 
    450                 455                 460                 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
465                 470                 475                 480 


Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys 
                485                 490                 495     


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            500                 505                 510         


Glu Ile Lys Arg 
        515     


<210>  362
<211>  1551
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  PIMS - W0003 (PN)

<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  Human VK3 leader

<220>
<221>  misc_feature
<222>  (61)..(69)
<223>  Leader-hinge junction

<220>
<221>  misc_feature
<222>  (70)..(114)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (115)..(765)
<223>  CH2CH3 region

<220>
<221>  misc_feature
<222>  (766)..(789)
<223>  Linker peptide

<220>
<221>  misc_feature
<222>  (790)..(1551)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (1153)..(1212)
<223>  Binding region linker

<400>  362
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt     60

gcctcgagcg agcccaaatc ttgtgacaaa actcacacat gtccaccgtg cccagcacct    120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg    180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag    240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg    300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac    360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc    420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc    480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc    540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag    600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg    660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg    720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaagggtg tccaccttgt    780

ccgaattctc aggtgcagct gaaggagtca gggcctggca gcgtggcgcc ctcacagagc    840

ctgtccatca catgcaccgt ctcagggttc tcattaaccg gctatggtgt aaactgggtt    900

cgccagcctc caggaaaggg tctggagtgg ctgggaatga tatggggtga tggaagcaca    960

gactataatt cagctctcaa atccagacta tcgatcacca aggacaactc caagagccaa   1020

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccagatacta ctgtgctcga   1080

gatggttata gtaactttca ttactatgtt atggactact ggggtcaagg aacctcagtc   1140

accgtctcct ctgggggtgg aggctctggt ggcggtggat ccggcggagg tgggtcgggt   1200

ggcggcggat ctgacattgt gctcacccaa tctccagctt ctttggctgt gtctctaggt   1260

cagagagcca ccatctcctg cagagccagt gaaagtgttg aatattatgt cacaagttta   1320

atgcagtggt accaacagaa accaggacag ccacccaagc tcctcatctc tgctgctagc   1380

aacgtagaat ctggggtccc tgccaggttt agtggcagtg ggtctgggac agactttagc   1440

ctcaacatcc atcctgtgga ggaggatgat attgcaatgt atttctgtca gcaaagtagg   1500

aaggttccat ggacgttcgg tggaggcacc aagctggaaa tcaaacgtta a            1551


<210>  363
<211>  516
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  PIMS - W0003 (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Human VK3 leader

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  Leader-hinge junction

<220>
<221>  misc_feature
<222>  (24)..(38)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  misc_feature
<222>  (256)..(263)
<223>  Linker peptide

<220>
<221>  misc_feature
<222>  (264)..(516)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (385)..(404)
<223>  Binding region linker

<400>  363

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ala Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro 
            260                 265                 270         


Gly Ser Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 
        275                 280                 285             


Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr 
305                 310                 315                 320 


Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn 
                325                 330                 335     


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
            340                 345                 350         


Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr 
        355                 360                 365             


Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
                405                 410                 415     


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
            420                 425                 430         


Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
        435                 440                 445             


Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 
    450                 455                 460                 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
465                 470                 475                 480 


Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys 
                485                 490                 495     


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            500                 505                 510         


Glu Ile Lys Arg 
        515     


<210>  364
<211>  1551
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  PIMS - W0004 (PN)

<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  Human VK3 leader

<220>
<221>  misc_feature
<222>  (61)..(69)
<223>  Leader-hinge junction

<220>
<221>  misc_feature
<222>  (70)..(114)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (115)..(765)
<223>  CH2CH3 region

<220>
<221>  misc_feature
<222>  (766)..(789)
<223>  Linker peptide

<220>
<221>  misc_feature
<222>  (790)..(1551)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (1153)..(1212)
<223>  Binding region linker

<400>  364
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt     60

gcctcgagag agcccaaatc ttgtgacaaa actcacacat gtccaccgtg cccagcacct    120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg    180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag    240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg    300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac    360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc    420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc    480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc    540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag    600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg    660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg    720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaagggtg tccaccttgt    780

ccgaattctc aggtgcagct gaaggagtca gggcctggca gcgtggcgcc ctcacagagc    840

ctgtccatca catgcaccgt ctcagggttc tcattaaccg gctatggtgt aaactgggtt    900

cgccagcctc caggaaaggg tctggagtgg ctgggaatga tatggggtga tggaagcaca    960

gactataatt cagctctcaa atccagacta tcgatcacca aggacaactc caagagccaa   1020

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccagatacta ctgtgctcga   1080

gatggttata gtaactttca ttactatgtt atggactact ggggtcaagg aacctcagtc   1140

accgtctcct ctgggggtgg aggctctggt ggcggtggat ccggcggagg tgggtcgggt   1200

ggcggcggat ctgacattgt gctcacccaa tctccagctt ctttggctgt gtctctaggt   1260

cagagagcca ccatctcctg cagagccagt gaaagtgttg aatattatgt cacaagttta   1320

atgcagtggt accaacagaa accaggacag ccacccaagc tcctcatctc tgctgctagc   1380

aacgtagaat ctggggtccc tgccaggttt agtggcagtg ggtctgggac agactttagc   1440

ctcaacatcc atcctgtgga ggaggatgat attgcaatgt atttctgtca gcaaagtagg   1500

aaggttccat ggacgttcgg tggaggcacc aagctggaaa tcaaacgtta a            1551


<210>  365
<211>  516
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  PIMS - W0004 (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Human VK3 leader

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  Leader-hinge junction

<220>
<221>  misc_feature
<222>  (24)..(38)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  misc_feature
<222>  (256)..(263)
<223>  Linker peptide

<220>
<221>  misc_feature
<222>  (264)..(516)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (385)..(404)
<223>  Binding region linker

<400>  365

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ala Ser Arg Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro 
            260                 265                 270         


Gly Ser Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 
        275                 280                 285             


Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr 
305                 310                 315                 320 


Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn 
                325                 330                 335     


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
            340                 345                 350         


Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr 
        355                 360                 365             


Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
                405                 410                 415     


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
            420                 425                 430         


Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
        435                 440                 445             


Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 
    450                 455                 460                 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
465                 470                 475                 480 


Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys 
                485                 490                 495     


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            500                 505                 510         


Glu Ile Lys Arg 
        515     


<210>  366
<211>  1551
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  PIMS - W0005 (PN)

<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  Human VK3 leader

<220>
<221>  misc_feature
<222>  (61)..(69)
<223>  Leader-hinge junction

<220>
<221>  misc_feature
<222>  (70)..(114)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (115)..(765)
<223>  CH2CH3 region

<220>
<221>  misc_feature
<222>  (766)..(789)
<223>  Linker peptide

<220>
<221>  misc_feature
<222>  (790)..(1551)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (1153)..(1212)
<223>  Binding region linker

<400>  366
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt     60

acctcgagag agcccaaatc ttgtgacaaa actcacacat gtccaccgtg cccagcacct    120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg    180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag    240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg    300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac    360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc    420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc    480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc    540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag    600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg    660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg    720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaagggtg tccaccttgt    780

ccgaattctc aggtgcagct gaaggagtca gggcctggca gcgtggcgcc ctcacagagc    840

ctgtccatca catgcaccgt ctcagggttc tcattaaccg gctatggtgt aaactgggtt    900

cgccagcctc caggaaaggg tctggagtgg ctgggaatga tatggggtga tggaagcaca    960

gactataatt cagctctcaa atccagacta tcgatcacca aggacaactc caagagccaa   1020

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccagatacta ctgtgctcga   1080

gatggttata gtaactttca ttactatgtt atggactact ggggtcaagg aacctcagtc   1140

accgtctcct ctgggggtgg aggctctggt ggcggtggat ccggcggagg tgggtcgggt   1200

ggcggcggat ctgacattgt gctcacccaa tctccagctt ctttggctgt gtctctaggt   1260

cagagagcca ccatctcctg cagagccagt gaaagtgttg aatattatgt cacaagttta   1320

atgcagtggt accaacagaa accaggacag ccacccaagc tcctcatctc tgctgctagc   1380

aacgtagaat ctggggtccc tgccaggttt agtggcagtg ggtctgggac agactttagc   1440

ctcaacatcc atcctgtgga ggaggatgat attgcaatgt atttctgtca gcaaagtagg   1500

aaggttccat ggacgttcgg tggaggcacc aagctggaaa tcaaacgtta a            1551


<210>  367
<211>  516
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  PIMS - W0005 (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Human VK3 leader

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  Leader-hinge junction

<220>
<221>  misc_feature
<222>  (24)..(38)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  misc_feature
<222>  (256)..(263)
<223>  Linker peptide

<220>
<221>  misc_feature
<222>  (264)..(516)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (385)..(404)
<223>  Binding domain

<400>  367

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Thr Ser Arg Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro 
            260                 265                 270         


Gly Ser Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 
        275                 280                 285             


Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr 
305                 310                 315                 320 


Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn 
                325                 330                 335     


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
            340                 345                 350         


Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr 
        355                 360                 365             


Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
                405                 410                 415     


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
            420                 425                 430         


Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
        435                 440                 445             


Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 
    450                 455                 460                 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
465                 470                 475                 480 


Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys 
                485                 490                 495     


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            500                 505                 510         


Glu Ile Lys Arg 
        515     


<210>  368
<211>  1548
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  PIMS - W0006 (PN)

<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  Human VK3 leader

<220>
<221>  misc_feature
<222>  (61)..(69)
<223>  Leader-hinge junction

<220>
<221>  misc_feature
<222>  (70)..(114)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (115)..(765)
<223>  CH2CH3 region

<220>
<221>  misc_feature
<222>  (766)..(789)
<223>  Linker peptide

<220>
<221>  misc_feature
<222>  (790)..(1551)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (1153)..(1212)
<223>  Binding region linker

<400>  368
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt     60

tctctcgagc ccaaatcttg tgacaaaact cacacatgtc caccgtgccc agcacctgaa    120

ctcctgggtg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc    180

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc    240

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag    300

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg    360

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag    420

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca    480

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat    540

ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc    600

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac    660

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac    720

aaccactaca cgcagaagag cctctccctg tctccgggta aagggtgtcc accttgtccg    780

aattctcagg tgcagctgaa ggagtcaggg cctggcagcg tggcgccctc acagagcctg    840

tccatcacat gcaccgtctc agggttctca ttaaccggct atggtgtaaa ctgggttcgc    900

cagcctccag gaaagggtct ggagtggctg ggaatgatat ggggtgatgg aagcacagac    960

tataattcag ctctcaaatc cagactatcg atcaccaagg acaactccaa gagccaagtt   1020

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca gatactactg tgctcgagat   1080

ggttatagta actttcatta ctatgttatg gactactggg gtcaaggaac ctcagtcacc   1140

gtctcctctg ggggtggagg ctctggtggc ggtggatccg gcggaggtgg gtcgggtggc   1200

ggcggatctg acattgtgct cacccaatct ccagcttctt tggctgtgtc tctaggtcag   1260

agagccacca tctcctgcag agccagtgaa agtgttgaat attatgtcac aagtttaatg   1320

cagtggtacc aacagaaacc aggacagcca cccaagctcc tcatctctgc tgctagcaac   1380

gtagaatctg gggtccctgc caggtttagt ggcagtgggt ctgggacaga ctttagcctc   1440

aacatccatc ctgtggagga ggatgatatt gcaatgtatt tctgtcagca aagtaggaag   1500

gttccatgga cgttcggtgg aggcaccaag ctggaaatca aacgttaa                1548


<210>  369
<211>  515
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  PIMS - W0006 (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Human VK3 leader

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  Leader-hinge junction

<220>
<221>  misc_feature
<222>  (24)..(38)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  misc_feature
<222>  (256)..(263)
<223>  Linker peptide

<220>
<221>  misc_feature
<222>  (264)..(516)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (385)..(404)
<223>  Binding region linker

<400>  369

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    50                  55                  60                  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  75                  80  


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                85                  90                  95      


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            100                 105                 110         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        115                 120                 125             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    130                 135                 140                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
145                 150                 155                 160 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                165                 170                 175     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            180                 185                 190         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        195                 200                 205             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    210                 215                 220                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
225                 230                 235                 240 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Cys 
                245                 250                 255     


Pro Pro Cys Pro Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 
            260                 265                 270         


Ser Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
        275                 280                 285             


Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly 
    290                 295                 300                 


Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp 
305                 310                 315                 320 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser 
                325                 330                 335     


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
            340                 345                 350         


Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr 
        355                 360                 365             


Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
                405                 410                 415     


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val 
            420                 425                 430         


Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly 
        435                 440                 445             


Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly 
    450                 455                 460                 


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu 
465                 470                 475                 480 


Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln 
                485                 490                 495     


Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
            500                 505                 510         


Ile Lys Arg 
        515 


<210>  370
<211>  1548
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  PIMS - W0007 (PN)

<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  Human VK3 leader

<220>
<221>  misc_feature
<222>  (61)..(66)
<223>  Leader-hinge junction

<220>
<221>  misc_feature
<222>  (67)..(111)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (112)..(762)
<223>  CH2CH3 region

<220>
<221>  misc_feature
<222>  (763)..(786)
<223>  Linker peptide

<220>
<221>  misc_feature
<222>  (787)..(1548)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (1150)..(1209)
<223>  Binding region linker

<400>  370
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt     60

gaactcgagc ccaaatcttg tgacaaaact cacacatgtc caccgtgccc agcacctgaa    120

ctcctgggtg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc    180

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc    240

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag    300

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg    360

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag    420

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca    480

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat    540

ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc    600

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac    660

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac    720

aaccactaca cgcagaagag cctctccctg tctccgggta aagggtgtcc accttgtccg    780

aattctcagg tgcagctgaa ggagtcaggg cctggcagcg tggcgccctc acagagcctg    840

tccatcacat gcaccgtctc agggttctca ttaaccggct atggtgtaaa ctgggttcgc    900

cagcctccag gaaagggtct ggagtggctg ggaatgatat ggggtgatgg aagcacagac    960

tataattcag ctctcaaatc cagactatcg atcaccaagg acaactccaa gagccaagtt   1020

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca gatactactg tgctcgagat   1080

ggttatagta actttcatta ctatgttatg gactactggg gtcaaggaac ctcagtcacc   1140

gtctcctctg ggggtggagg ctctggtggc ggtggatccg gcggaggtgg gtcgggtggc   1200

ggcggatctg acattgtgct cacccaatct ccagcttctt tggctgtgtc tctaggtcag   1260

agagccacca tctcctgcag agccagtgaa agtgttgaat attatgtcac aagtttaatg   1320

cagtggtacc aacagaaacc aggacagcca cccaagctcc tcatctctgc tgctagcaac   1380

gtagaatctg gggtccctgc caggtttagt ggcagtgggt ctgggacaga ctttagcctc   1440

aacatccatc ctgtggagga ggatgatatt gcaatgtatt tctgtcagca aagtaggaag   1500

gttccatgga cgttcggtgg aggcaccaag ctggaaatca aacgttaa                1548


<210>  371
<211>  515
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  PIMS - W0007 (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Human VK3 leader

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  Leader-hinge junction

<220>
<221>  misc_feature
<222>  (23)..(37)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (38)..(254)
<223>  CH2CH3 region

<220>
<221>  misc_feature
<222>  (255)..(262)
<223>  Linker peptide

<220>
<221>  misc_feature
<222>  (263)..(515)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (384)..(403)
<223>  Binding region linker

<400>  371

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    50                  55                  60                  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  75                  80  


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                85                  90                  95      


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            100                 105                 110         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        115                 120                 125             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    130                 135                 140                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
145                 150                 155                 160 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                165                 170                 175     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            180                 185                 190         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        195                 200                 205             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    210                 215                 220                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
225                 230                 235                 240 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Cys 
                245                 250                 255     


Pro Pro Cys Pro Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 
            260                 265                 270         


Ser Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
        275                 280                 285             


Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly 
    290                 295                 300                 


Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp 
305                 310                 315                 320 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser 
                325                 330                 335     


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
            340                 345                 350         


Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr 
        355                 360                 365             


Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
                405                 410                 415     


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val 
            420                 425                 430         


Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly 
        435                 440                 445             


Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly 
    450                 455                 460                 


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu 
465                 470                 475                 480 


Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln 
                485                 490                 495     


Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
            500                 505                 510         


Ile Lys Arg 
        515 


<210>  372
<211>  1503
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  PIMS - W0008 (PN)

<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  Human VK3 leader

<220>
<221>  misc_feature
<222>  (61)..(66)
<223>  Leader-hinge junction

<220>
<221>  misc_feature
<222>  (67)..(111)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (112)..(762)
<223>  CH2CH3 region

<220>
<221>  misc_feature
<222>  (763)..(786)
<223>  Linker peptide

<220>
<221>  misc_feature
<222>  (787)..(1503)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (1150)..(1185)
<223>  Binding region linker

<400>  372
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt     60

gaactcgagc ccaaatcttg tgacaaaact cacacatgtc caccgtgccc agcacctgaa    120

ctcctgggtg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc    180

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc    240

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag    300

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg    360

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag    420

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca    480

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat    540

ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc    600

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac    660

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac    720

aaccactaca cgcagaagag cctctccctg tctccgggta aagggtgtcc accttgtccg    780

aattctcagg tgcagctggt gcagtctggt gctgagagca agaagcctgg ggcctcagtg    840

aaggtttcct gcaaggccag cggatacacc ttcaccagct acaatatgca ctgggtgcga    900

caggcgcctg gacaagggct agagtggatg ggagctatct atcctggaaa tggtgataca    960

tcctacaatc agaagttcaa gggcagggtc accatgacca gagacacgtc cacgagcaca   1020

gtctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcccga   1080

agctactata gtaactctta ctggtacttc gatctctggg gccgcggcac cctggtcact   1140

gtctcctcgg ggggcggtgg atcgggcggt ggtggatctg ctagcgaaat tgtgttgaca   1200

cagtctccag ccaccctgtc tttgtctcca ggtgaaagag ccaccctctc ctgcagggcc   1260

agttccagtg ttagctacat tgtttggtac caacagaaac ctggccaggc acctaggctc   1320

ctcatctatg ccccatccaa cctggcttct ggaataccag ccaggttcag tggcagtgga   1380

tccgggacag acttcactct caccatcagc agtcttgagc ctgaagattt tgcagtttat   1440

tactgtcagc agtggagttt taaccctccc acgttcggcc aagggaccaa ggtggaaatc   1500

aaa                                                                 1503


<210>  373
<211>  501
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  PIMS - W0008 (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Human VK3 leader

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  Leader-hinge junction

<220>
<221>  misc_feature
<222>  (23)..(37)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (38)..(254)
<223>  CH2CH3 region

<220>
<221>  misc_feature
<222>  (255)..(262)
<223>  Linker peptide

<220>
<221>  misc_feature
<222>  (263)..(501)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (384)..(395)
<223>  Binding region linker

<400>  373

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    50                  55                  60                  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  75                  80  


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                85                  90                  95      


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            100                 105                 110         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        115                 120                 125             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    130                 135                 140                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
145                 150                 155                 160 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                165                 170                 175     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            180                 185                 190         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        195                 200                 205             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    210                 215                 220                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
225                 230                 235                 240 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Cys 
                245                 250                 255     


Pro Pro Cys Pro Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            260                 265                 270         


Ser Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        275                 280                 285             


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly 
    290                 295                 300                 


Gln Gly Leu Glu Trp Met Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
305                 310                 315                 320 


Ser Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr 
                325                 330                 335     


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            340                 345                 350         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Tyr Tyr Ser Asn Ser Tyr Trp 
        355                 360                 365             


Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Glu Ile Val Leu Thr 
385                 390                 395                 400 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
                405                 410                 415     


Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile Val Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ala Pro Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    450                 455                 460                 


Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Gln Gly Thr 
                485                 490                 495     


Lys Val Glu Ile Lys 
            500     


<210>  374
<211>  1518
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  PIMS - W0009 (PN)

<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  Human VK3 leader

<220>
<221>  misc_feature
<222>  (61)..(66)
<223>  Leader-hinge junction

<220>
<221>  misc_feature
<222>  (67)..(111)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (112)..(762)
<223>  CH2CH3 region

<220>
<221>  misc_feature
<222>  (763)..(786)
<223>  Linker peptide

<220>
<221>  misc_feature
<222>  (787)..(1518)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (1150)..(1200)
<223>  Binding region linker

<400>  374
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt     60

gaactcgagc ccaaatcttg tgacaaaact cacacatgtc caccgtgccc agcacctgaa    120

ctcctgggtg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc    180

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc    240

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag    300

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg    360

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag    420

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca    480

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat    540

ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc    600

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac    660

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac    720

aaccactaca cgcagaagag cctctccctg tctccgggta aagggtgtcc accttgtccg    780

aattctcagg tgcagctggt gcagtctggt gctgagagca agaagcctgg ggcctcagtg    840

aaggtttcct gcaaggccag cggatacacc ttcaccagct acaatatgca ctgggtgcga    900

caggcgcctg gacaagggct agagtggatg ggagctatct atcctggaaa tggtgataca    960

tcctacaatc agaagttcaa gggcagggtc accatgacca gagacacgtc cacgagcaca   1020

gtctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcccga   1080

agctactata gtaactctta ctggtacttc gatctctggg gccgcggcac cctggtcact   1140

gtctcctcgg ggggcggtgg atcgggcggt ggtggatctg gaggaggtgg gtctgctagc   1200

gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccaggtga aagagccacc   1260

ctctcctgca gggccagttc cagtgttagc tacattgttt ggtaccaaca gaaacctggc   1320

caggcaccta ggctcctcat ctatgcccca tccaacctgg cttctggaat accagccagg   1380

ttcagtggca gtggatccgg gacagacttc actctcacca tcagcagtct tgagcctgaa   1440

gattttgcag tttattactg tcagcagtgg agttttaacc ctcccacgtt cggccaaggg   1500

accaaggtgg aaatcaaa                                                 1518


<210>  375
<211>  506
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  PIMS - W0009 (AA)

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Human VK3 leader

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  Leader-hinge junction

<220>
<221>  misc_feature
<222>  (23)..(37)
<223>  Hinge region

<220>
<221>  misc_feature
<222>  (255)..(262)
<223>  Linker peptide

<220>
<221>  misc_feature
<222>  (263)..(506)
<223>  Binding domain

<220>
<221>  misc_feature
<222>  (384)..(400)
<223>  Binding region linker

<400>  375

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    50                  55                  60                  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  75                  80  


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                85                  90                  95      


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            100                 105                 110         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        115                 120                 125             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    130                 135                 140                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
145                 150                 155                 160 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                165                 170                 175     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            180                 185                 190         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        195                 200                 205             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    210                 215                 220                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
225                 230                 235                 240 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Cys 
                245                 250                 255     


Pro Pro Cys Pro Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            260                 265                 270         


Ser Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        275                 280                 285             


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly 
    290                 295                 300                 


Gln Gly Leu Glu Trp Met Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
305                 310                 315                 320 


Ser Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr 
                325                 330                 335     


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            340                 345                 350         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Tyr Tyr Ser Asn Ser Tyr Trp 
        355                 360                 365             


Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser 
385                 390                 395                 400 


Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
                405                 410                 415     


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            420                 425                 430         


Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        435                 440                 445             


Ala Pro Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
465                 470                 475                 480 


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                485                 490                 495     


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            500                 505     


<210>  376
<211>  330
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IgG CH2 domain_nt

<400>  376
gcacctgaac tcctgggtgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc     60

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac    120

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag    180

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac    240

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc    300

cccatcgaga aaaccatctc caaagccaaa                                     330


<210>  377
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgG CH2 domain _aa

<400>  377

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  378
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IgG CH3 domain_nt

<400>  378
gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     60

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc caagcgacat cgccgtggag    120

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc    180

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg    240

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc    300

ctctccctgt ctccgggtaa a                                              321


<210>  379
<211>  107
<212>  PRT
<213>  IgG CH3 domain_aa

<400>  379

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  380
<211>  1509
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0008_pims_CD20_10 (13bp - 1521bp, 
       direct)

<400>  380
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaactcgagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctgaa      120

ctcctgggtg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      180

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      240

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      300

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      360

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      420

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      480

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat      540

ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc      600

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac      660

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac      720

aaccactaca cgcagaagag cctctccctg tctccgggta aggggtgtcc accttgtccg      780

aattctcagg tgcagctggt gcagtctggt gctgagagca agaagcctgg ggcctcagtg      840

aaggtttcct gcaaggccag cggatacacc ttcaccagct acaatatgca ctgggtgcga      900

caggcgcctg gacaagggct agagtggatg ggagctatct atcctggaaa tggtgataca      960

tcctacaatc agaagttcaa gggcagggtc accatgacca gagacacgtc cacgagcaca     1020

gtctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcccga     1080

agctactata gtaactctta ctggtacttc gatctctggg gccgcggcac cctggtcact     1140

gtctcctcgg ggggcggtgg atcgggcggt ggtggatctg ctagcgaaat tgtgttgaca     1200

cagtctccag ccaccctgtc tttgtctcca ggtgaaagag ccaccctctc ctgcagggcc     1260

agttccagtg ttagctacat tgtttggtac caacagaaac ctggccaggc acctaggctc     1320

ctcatctatg ccccatccaa cctggcttct ggaataccag ccaggttcag tggcagtgga     1380

tccgggacag acttcactct caccatcagc agtcttgagc ctgaagattt tgcagtttat     1440

tactgtcagc agtggagttt taaccctccc acgttcggcc aagggaccaa ggtggaaatc     1500

aaagactga                                                             1509


<210>  381
<211>  502
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0008_pims_CD20_10 (1aa - 502aa)


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(22)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (23)..(37)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (38)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(262)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (263)..(292)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (293)..(297)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (298)..(311)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (312)..(328)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (329)..(360)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (361)..(372)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (373)..(383)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (384)..(395)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (396)..(418)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (419)..(428)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (429)..(443)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (444)..(450)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (451)..(482)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (483)..(491)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (492)..(502)
<223>  Light region

<400>  381

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    50                  55                  60                  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  75                  80  


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                85                  90                  95      


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            100                 105                 110         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        115                 120                 125             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    130                 135                 140                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
145                 150                 155                 160 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                165                 170                 175     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            180                 185                 190         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        195                 200                 205             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    210                 215                 220                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
225                 230                 235                 240 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Cys 
                245                 250                 255     


Pro Pro Cys Pro Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            260                 265                 270         


Ser Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        275                 280                 285             


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly 
    290                 295                 300                 


Gln Gly Leu Glu Trp Met Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
305                 310                 315                 320 


Ser Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr 
                325                 330                 335     


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            340                 345                 350         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Tyr Tyr Ser Asn Ser Tyr Trp 
        355                 360                 365             


Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Glu Ile Val Leu Thr 
385                 390                 395                 400 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
                405                 410                 415     


Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile Val Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ala Pro Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    450                 455                 460                 


Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Gln Gly Thr 
                485                 490                 495     


Lys Val Glu Ile Lys Asp 
            500         


<210>  382
<211>  1524
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0009_pims_CD20_15 (13bp - 1536bp, 
       direct)

<400>  382
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaactcgagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctgaa      120

ctcctgggtg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      180

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      240

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      300

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      360

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      420

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      480

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat      540

ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc      600

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac      660

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac      720

aaccactaca cgcagaagag cctctccctg tctccgggta aggggtgtcc accttgtccg      780

aattctcagg tgcagctggt gcagtctggt gctgagagca agaagcctgg ggcctcagtg      840

aaggtttcct gcaaggccag cggatacacc ttcaccagct acaatatgca ctgggtgcga      900

caggcgcctg gacaagggct agagtggatg ggagctatct atcctggaaa tggtgataca      960

tcctacaatc agaagttcaa gggcagggtc accatgacca gagacacgtc cacgagcaca     1020

gtctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcccga     1080

agctactata gtaactctta ctggtacttc gatctctggg gccgcggcac cctggtcact     1140

gtctcctcgg ggggcggtgg atcgggcggt ggtggatctg gaggaggtgg gtctgctagc     1200

gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccaggtga aagagccacc     1260

ctctcctgca gggccagttc cagtgttagc tacattgttt ggtaccaaca gaaacctggc     1320

caggcaccta ggctcctcat ctatgcccca tccaacctgg cttctggaat accagccagg     1380

ttcagtggca gtggatccgg gacagacttc actctcacca tcagcagtct tgagcctgaa     1440

gattttgcag tttattactg tcagcagtgg agttttaacc ctcccacgtt cggccaaggg     1500

accaaggtgg aaatcaaaga ctga                                            1524


<210>  383
<211>  507
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0009_pims_CD20_15_protein (1aa - 507aa)


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(22)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (23)..(37)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (38)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(262)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (263)..(292)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (293)..(297)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (298)..(311)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (312)..(328)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (329)..(360)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (361)..(372)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (373)..(383)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (384)..(400)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (401)..(423)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (424)..(433)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (434)..(448)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (449)..(455)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (456)..(487)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (488)..(496)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (497)..(507)
<223>  Light region

<400>  383

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    50                  55                  60                  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  75                  80  


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                85                  90                  95      


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            100                 105                 110         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        115                 120                 125             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    130                 135                 140                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
145                 150                 155                 160 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                165                 170                 175     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            180                 185                 190         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        195                 200                 205             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    210                 215                 220                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
225                 230                 235                 240 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Cys 
                245                 250                 255     


Pro Pro Cys Pro Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            260                 265                 270         


Ser Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        275                 280                 285             


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly 
    290                 295                 300                 


Gln Gly Leu Glu Trp Met Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
305                 310                 315                 320 


Ser Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr 
                325                 330                 335     


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            340                 345                 350         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Tyr Tyr Ser Asn Ser Tyr Trp 
        355                 360                 365             


Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser 
385                 390                 395                 400 


Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
                405                 410                 415     


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            420                 425                 430         


Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        435                 440                 445             


Ala Pro Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
465                 470                 475                 480 


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                485                 490                 495     


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Asp 
            500                 505         


<210>  384
<211>  1524
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0009_H8 (13bp - 1536bp, direct)

<400>  384
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaactcgagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctgaa      120

ctcctgggtg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      180

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      240

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      300

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      360

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      420

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      480

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat      540

ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc      600

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac      660

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac      720

aaccactaca cgcagaagag cctctccctg tctccgggta aaggatctcc accttctccg      780

aattctcagg tgcagctggt gcagtctggt gctgagagca agaagcctgg ggcctcagtg      840

aaggtttcct gcaaggccag cggatacacc ttcaccagct acaatatgca ctgggtgcga      900

caggcgcctg gacaagggct agagtggatg ggagctatct atcctggaaa tggtgataca      960

tcctacaatc agaagttcaa gggcagggtc accatgacca gagacacgtc cacgagcaca     1020

gtctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcccga     1080

agctactata gtaactctta ctggtacttc gatctctggg gccgcggcac cctggtcact     1140

gtctcctcgg ggggcggtgg atcgggcggt ggtggatctg gaggaggtgg gtctgctagc     1200

gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccaggtga aagagccacc     1260

ctctcctgca gggccagttc cagtgttagc tacattgttt ggtaccaaca gaaacctggc     1320

caggcaccta ggctcctcat ctatgcccca tccaacctgg cttctggaat accagccagg     1380

ttcagtggca gtggatccgg gacagacttc actctcacca tcagcagtct tgagcctgaa     1440

gattttgcag tttattactg tcagcagtgg agttttaacc ctcccacgtt cggccaaggg     1500

accaaggtgg aaatcaaaga ctga                                            1524


<210>  385
<211>  508
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0009_H8 (1aa - 508aa)


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(22)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (23)..(37)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (38)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(262)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (263)..(292)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (293)..(297)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (298)..(311)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (312)..(328)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (329)..(360)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (361)..(372)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (373)..(383)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (384)..(400)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (401)..(423)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (424)..(433)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (434)..(448)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (449)..(455)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (456)..(487)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (488)..(496)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (497)..(507)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (508)..(508)
<223>  Xaa is a stop codon

<400>  385

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    50                  55                  60                  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  75                  80  


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                85                  90                  95      


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            100                 105                 110         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        115                 120                 125             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    130                 135                 140                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
145                 150                 155                 160 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                165                 170                 175     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            180                 185                 190         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        195                 200                 205             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    210                 215                 220                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
225                 230                 235                 240 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser 
                245                 250                 255     


Pro Pro Ser Pro Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            260                 265                 270         


Ser Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        275                 280                 285             


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly 
    290                 295                 300                 


Gln Gly Leu Glu Trp Met Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
305                 310                 315                 320 


Ser Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr 
                325                 330                 335     


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            340                 345                 350         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Tyr Tyr Ser Asn Ser Tyr Trp 
        355                 360                 365             


Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser 
385                 390                 395                 400 


Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
                405                 410                 415     


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            420                 425                 430         


Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        435                 440                 445             


Ala Pro Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
465                 470                 475                 480 


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                485                 490                 495     


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Asp Xaa 
            500                 505             


<210>  386
<211>  1518
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0009_H9 (13bp - 1530bp, direct)

<400>  386
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaactcgagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctgaa      120

ctcctgggtg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      180

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      240

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      300

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      360

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      420

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      480

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat      540

ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc      600

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac      660

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac      720

aaccactaca cgcagaagag cctctccctg tctccgggtt ctccaccttc tccgaattct      780

caggtgcagc tggtgcagtc tggtgctgag agcaagaagc ctggggcctc agtgaaggtt      840

tcctgcaagg ccagcggata caccttcacc agctacaata tgcactgggt gcgacaggcg      900

cctggacaag ggctagagtg gatgggagct atctatcctg gaaatggtga tacatcctac      960

aatcagaagt tcaagggcag ggtcaccatg accagagaca cgtccacgag cacagtctac     1020

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc ccgaagctac     1080

tatagtaact cttactggta cttcgatctc tggggccgcg gcaccctggt cactgtctcc     1140

tcggggggcg gtggatcggg cggtggtgga tctggaggag gtgggtctgc tagcgaaatt     1200

gtgttgacac agtctccagc caccctgtct ttgtctccag gtgaaagagc caccctctcc     1260

tgcagggcca gttccagtgt tagctacatt gtttggtacc aacagaaacc tggccaggca     1320

cctaggctcc tcatctatgc cccatccaac ctggcttctg gaataccagc caggttcagt     1380

ggcagtggat ccgggacaga cttcactctc accatcagca gtcttgagcc tgaagatttt     1440

gcagtttatt actgtcagca gtggagtttt aaccctccca cgttcggcca agggaccaag     1500

gtggaaatca aagactga                                                   1518


<210>  387
<211>  506
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0009_H9 (1aa - 506aa)


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(22)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (23)..(37)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (38)..(252)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (253)..(260)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (261)..(290)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (291)..(295)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (296)..(309)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (310)..(326)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (327)..(358)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (359)..(370)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (371)..(381)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (382)..(398)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (399)..(421)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (422)..(431)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (432)..(446)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (447)..(453)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (454)..(485)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (486)..(494)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (495)..(505)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (506)..(506)
<223>  Xaa is a stop codon

<400>  387

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    50                  55                  60                  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  75                  80  


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                85                  90                  95      


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            100                 105                 110         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        115                 120                 125             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    130                 135                 140                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
145                 150                 155                 160 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                165                 170                 175     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            180                 185                 190         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        195                 200                 205             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    210                 215                 220                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
225                 230                 235                 240 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Pro Pro 
                245                 250                 255     


Ser Pro Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Ser Lys 
            260                 265                 270         


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        275                 280                 285             


Phe Thr Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    290                 295                 300                 


Leu Glu Trp Met Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr 
305                 310                 315                 320 


Asn Gln Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr 
                325                 330                 335     


Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            340                 345                 350         


Val Tyr Tyr Cys Ala Arg Ser Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe 
        355                 360                 365             


Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Glu Ile 
385                 390                 395                 400 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                405                 410                 415     


Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile Val Trp 
            420                 425                 430         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ala Pro 
        435                 440                 445             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    450                 455                 460                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
465                 470                 475                 480 


Ala Val Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly 
                485                 490                 495     


Gln Gly Thr Lys Val Glu Ile Lys Asp Xaa 
            500                 505     


<210>  388
<211>  1551
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0009_H10 (13bp - 1563bp, direct)

<400>  388
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaactcgagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctgaa      120

ctcctgggtg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      180

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      240

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      300

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      360

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      420

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      480

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat      540

ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc      600

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac      660

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac      720

aaccactaca cgcagaagag cctctccctg tctccgggta aggagcccaa atctaccgac      780

aaaactcaca catgtccacc ctgcccgaat tctcaggtgc agctggtgca gtctggtgct      840

gagagcaaga agcctggggc ctcagtgaag gtttcctgca aggccagcgg atacaccttc      900

accagctaca atatgcactg ggtgcgacag gcgcctggac aagggctaga gtggatggga      960

gctatctatc ctggaaatgg tgatacatcc tacaatcaga agttcaaggg cagggtcacc     1020

atgaccagag acacgtccac gagcacagtc tacatggagc tgagcagcct gagatctgag     1080

gacacggccg tgtattactg tgcccgaagc tactatagta actcttactg gtacttcgat     1140

ctctggggcc gcggcaccct ggtcactgtc tcctcggggg gcggtggatc gggcggtggt     1200

ggatctggag gaggtgggtc tgctagcgaa attgtgttga cacagtctcc agccaccctg     1260

tctttgtctc caggtgaaag agccaccctc tcctgcaggg ccagttccag tgttagctac     1320

attgtttggt accaacagaa acctggccag gcacctaggc tcctcatcta tgccccatcc     1380

aacctggctt ctggaatacc agccaggttc agtggcagtg gatccgggac agacttcact     1440

ctcaccatca gcagtcttga gcctgaagat tttgcagttt attactgtca gcagtggagt     1500

tttaaccctc ccacgttcgg ccaagggacc aaggtggaaa tcaaagactg a              1551


<210>  389
<211>  517
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0009_H10 (1aa - 517aa)


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(22)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (23)..(37)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (38)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(271)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (272)..(301)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (302)..(306)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (307)..(320)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (321)..(337)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (338)..(369)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (370)..(381)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (382)..(392)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (393)..(409)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (410)..(432)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (433)..(442)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (443)..(457)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (458)..(464)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (465)..(496)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (497)..(505)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (506)..(516)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (517)..(517)
<223>  Xaa is a stop codon

<400>  389

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    50                  55                  60                  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  75                  80  


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                85                  90                  95      


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            100                 105                 110         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        115                 120                 125             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    130                 135                 140                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
145                 150                 155                 160 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                165                 170                 175     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            180                 185                 190         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        195                 200                 205             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    210                 215                 220                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
225                 230                 235                 240 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Glu Pro 
                245                 250                 255     


Lys Ser Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn Ser Gln 
            260                 265                 270         


Val Gln Leu Val Gln Ser Gly Ala Glu Ser Lys Lys Pro Gly Ala Ser 
        275                 280                 285             


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn 
    290                 295                 300                 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
305                 310                 315                 320 


Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
                325                 330                 335     


Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met 
            340                 345                 350         


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        355                 360                 365             


Arg Ser Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Leu Trp Gly Arg 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Ala Ser Glu Ile Val Leu Thr Gln Ser 
                405                 410                 415     


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
            420                 425                 430         


Arg Ala Ser Ser Ser Val Ser Tyr Ile Val Trp Tyr Gln Gln Lys Pro 
        435                 440                 445             


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ala Pro Ser Asn Leu Ala Ser 
    450                 455                 460                 


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
465                 470                 475                 480 


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
                485                 490                 495     


Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
            500                 505                 510         


Glu Ile Lys Asp Xaa 
        515         


<210>  390
<211>  1527
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0011 (13bp - 1539bp, direct)

<400>  390
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaggggtg tccaccttgt      780

ccgaattctc aggtgcagct ggtgcagtct ggtgctgaga gcaagaagcc tggggcctca      840

gtgaaggttt cctgcaaggc cagcggatac accttcacca gctacaatat gcactgggtg      900

cgacaggcgc ctggacaagg gctagagtgg atgggagcta tctatcctgg aaatggtgat      960

acatcctaca atcagaagtt caagggcagg gtcaccatga ccagagacac gtccacgagc     1020

acagtctaca tggagctgag cagcctgaga tctgaggaca cggccgtgta ttactgtgcc     1080

cgaagctact atagtaactc ttactggtac ttcgatctct ggggccgcgg caccctggtc     1140

actgtctcct cggggggcgg tggatcgggc ggtggtggat ctggaggagg tgggtctgct     1200

agcgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg tgaaagagcc     1260

accctctcct gcagggccag ttccagtgtt agctacattg tttggtacca acagaaacct     1320

ggccaggcac ctaggctcct catctatgcc ccatccaacc tggcttctgg aataccagcc     1380

aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag tcttgagcct     1440

gaagattttg cagtttatta ctgtcagcag tggagtttta accctcccac gttcggccaa     1500

gggaccaagg tggaaatcaa agactga                                         1527


<210>  391
<211>  508
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0011_prot (1aa - 509aa)


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (256)..(263)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (264)..(293)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (294)..(298)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (299)..(312)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (313)..(329)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (330)..(361)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (362)..(373)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (374)..(384)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (385)..(401)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (402)..(424)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (425)..(434)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (435)..(449)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (450)..(456)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (457)..(488)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (489)..(497)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (498)..(508)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (509)..(509)
<223>  Xaa is a stop codon

<400>  391

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala 
            260                 265                 270         


Glu Ser Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
        275                 280                 285             


Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro 
    290                 295                 300                 


Gly Gln Gly Leu Glu Trp Met Gly Ala Ile Tyr Pro Gly Asn Gly Asp 
305                 310                 315                 320 


Thr Ser Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp 
                325                 330                 335     


Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
            340                 345                 350         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Tyr Tyr Ser Asn Ser Tyr 
        355                 360                 365             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
385                 390                 395                 400 


Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
                405                 410                 415     


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr 
            420                 425                 430         


Ile Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        435                 440                 445             


Tyr Ala Pro Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    450                 455                 460                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
465                 470                 475                 480 


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro 
                485                 490                 495     


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Asp 
            500                 505             


<210>  392
<211>  1479
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide DNE090 - human VK3 leader through VK3

<400>  392
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaggggtg tccaccttgt      780

ccgaattctg aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct      840

ctgaagattt cctgtaaggg atccggatac agctttacca gctacaacat gcactgggtg      900

cgccagatgc ccgggaaagg cctagagtgg atgggggcta tctatcctgg aaatggtgat      960

acatcctaca atcagaagtt caagggccag gtcactatct cggccgacaa gtccatcagc     1020

accgcctacc tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca     1080

cgcagctact atagtaactc ttactggtac ttcgatctct ggggccgcgg caccctggtc     1140

accgtctcct cggctagcga aattgtgttg acacagtctc cagccaccct gtctttgtct     1200

ccaggtgaaa gagccaccct ctcctgcagg gccagtcaga gtgttagcta cattgtttgg     1260

taccaacaga aacctggcca ggcacctagg ctcctcatct atgccccatc caacctggct     1320

tctggaatac cagccaggtt cagtggcagt ggatccggga cagacttcac tctcaccatc     1380

agcagtcttg agcctgaaga ttttgcagtt tattactgtc agcagtggag ttttaaccct     1440

cccacgttcg gccaagggac caaggtggaa atcaaatga                            1479


<210>  393
<211>  493
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide DNE090 - VK3 leader through VK3


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (256)..(263)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (264)..(293)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (294)..(298)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (299)..(312)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (313)..(329)
<223>  Heavy chain CDR bus-domain

<220>
<221>  MISC_FEATURE
<222>  (330)..(361)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (362)..(373)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (374)..(384)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (385)..(386)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (387)..(409)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (410)..(419)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (420)..(434)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (435)..(441)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (442)..(473)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (474)..(482)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (483)..(492)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (493)..(493)
<223>  Xaa is a stop codon

<400>  393

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
            260                 265                 270         


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
        275                 280                 285             


Gly Tyr Ser Phe Thr Ser Tyr Asn Met His Trp Val Arg Gln Met Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Tyr Pro Gly Asn Gly Asp 
305                 310                 315                 320 


Thr Ser Tyr Asn Gln Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp 
                325                 330                 335     


Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
            340                 345                 350         


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser Tyr Tyr Ser Asn Ser Tyr 
        355                 360                 365             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380                 


Ala Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
385                 390                 395                 400 


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
                405                 410                 415     


Tyr Ile Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
            420                 425                 430         


Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
        435                 440                 445             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
    450                 455                 460                 


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro 
465                 470                 475                 480 


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Xaa 
                485                 490             


<210>  394
<211>  1494
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide DNE091 - human VK3 leader through VK3

<400>  394
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaggggtg tccaccttgt      780

ccgaattctg aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct      840

ctgaagattt cctgtaaggg atccggatac agctttacca gctacaacat gcactgggtg      900

cgccagatgc ccgggaaagg cctagagtgg atgggggcta tctatcctgg aaatggtgat      960

acatcctaca atcagaagtt caagggccag gtcactatct cggccgacaa gtccatcagc     1020

accgcctacc tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca     1080

cgcagctact atagtaactc ttactggtac ttcgatctct ggggccgcgg caccctggtc     1140

accgtctcct cggggggcgg tggatcggct agcgaaattg tgttgacaca gtctccagcc     1200

accctgtctt tgtctccagg tgaaagagcc accctctcct gcagggccag tcagagtgtt     1260

agctacattg tttggtacca acagaaacct ggccaggcac ctaggctcct catctatgcc     1320

ccatccaacc tggcttctgg aataccagcc aggttcagtg gcagtggatc cgggacagac     1380

ttcactctca ccatcagcag tcttgagcct gaagattttg cagtttatta ctgtcagcag     1440

tggagtttta accctcccac gttcggccaa gggaccaagg tggaaatcaa atga           1494


<210>  395
<211>  498
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide DNE091 - VK3 leader through VK3


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (256)..(263)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (264)..(293)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (294)..(298)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (299)..(312)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (313)..(329)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (330)..(361)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (362)..(373)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (374)..(384)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (385)..(391)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (392)..(414)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (415)..(424)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (425)..(439)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (440)..(446)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (447)..(478)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (479)..(487)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (488)..(497)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (498)..(498)
<223>  Xaa is a stop codon

<400>  395

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
            260                 265                 270         


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
        275                 280                 285             


Gly Tyr Ser Phe Thr Ser Tyr Asn Met His Trp Val Arg Gln Met Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Tyr Pro Gly Asn Gly Asp 
305                 310                 315                 320 


Thr Ser Tyr Asn Gln Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp 
                325                 330                 335     


Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
            340                 345                 350         


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser Tyr Tyr Ser Asn Ser Tyr 
        355                 360                 365             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Ala Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
385                 390                 395                 400 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
                405                 410                 415     


Ser Gln Ser Val Ser Tyr Ile Val Trp Tyr Gln Gln Lys Pro Gly Gln 
            420                 425                 430         


Ala Pro Arg Leu Leu Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Ile 
        435                 440                 445             


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    450                 455                 460                 


Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
465                 470                 475                 480 


Trp Ser Phe Asn Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
                485                 490                 495     


Lys Xaa 
        


<210>  396
<211>  1509
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide DNE092 - VK3 leader through VK3

<400>  396
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaggggtg tccaccttgt      780

ccgaattctg aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct      840

ctgaagattt cctgtaaggg atccggatac agctttacca gctacaacat gcactgggtg      900

cgccagatgc ccgggaaagg cctagagtgg atgggggcta tctatcctgg aaatggtgat      960

acatcctaca atcagaagtt caagggccag gtcactatct cggccgacaa gtccatcagc     1020

accgcctacc tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca     1080

cgcagctact atagtaactc ttactggtac ttcgatctct ggggccgcgg caccctggtc     1140

accgtctcct cggggggcgg tggatcgggc ggtggtggat ctgctagcga aattgtgttg     1200

acacagtctc cagccaccct gtctttgtct ccaggtgaaa gagccaccct ctcctgcagg     1260

gccagtcaga gtgttagcta cattgtttgg taccaacaga aacctggcca ggcacctagg     1320

ctcctcatct atgccccatc caacctggct tctggaatac cagccaggtt cagtggcagt     1380

ggatccggga cagacttcac tctcaccatc agcagtcttg agcctgaaga ttttgcagtt     1440

tattactgtc agcagtggag ttttaaccct cccacgttcg gccaagggac caaggtggaa     1500

atcaaatga                                                             1509


<210>  397
<211>  503
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide DNE092 - VK3 leader through VK3


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (256)..(263)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (264)..(293)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (294)..(298)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (299)..(312)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (313)..(329)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (330)..(361)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (362)..(373)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (374)..(384)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (385)..(396)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (397)..(419)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (420)..(429)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (430)..(444)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (445)..(451)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (452)..(483)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (484)..(492)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (493)..(502)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (503)..(503)
<223>  Xaa is a stop codon

<400>  397

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
            260                 265                 270         


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
        275                 280                 285             


Gly Tyr Ser Phe Thr Ser Tyr Asn Met His Trp Val Arg Gln Met Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Tyr Pro Gly Asn Gly Asp 
305                 310                 315                 320 


Thr Ser Tyr Asn Gln Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp 
                325                 330                 335     


Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
            340                 345                 350         


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser Tyr Tyr Ser Asn Ser Tyr 
        355                 360                 365             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Glu Ile Val Leu 
385                 390                 395                 400 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
                405                 410                 415     


Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Ile Val Trp Tyr Gln 
            420                 425                 430         


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ala Pro Ser Asn 
        435                 440                 445             


Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    450                 455                 460                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Gln Gly 
                485                 490                 495     


Thr Lys Val Glu Ile Lys Xaa 
            500             


<210>  398
<211>  1524
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide DNE093 - human VK3 leader through VK3

<400>  398
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaggggtg tccaccttgt      780

ccgaattctg aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct      840

ctgaagattt cctgtaaggg atccggatac agctttacca gctacaacat gcactgggtg      900

cgccagatgc ccgggaaagg cctagagtgg atgggggcta tctatcctgg aaatggtgat      960

acatcctaca atcagaagtt caagggccag gtcactatct cggccgacaa gtccatcagc     1020

accgcctacc tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca     1080

cgcagctact atagtaactc ttactggtac ttcgatctct ggggccgcgg caccctggtc     1140

accgtctcct cggggggcgg tggatcgggc ggtggtggat ctggaggagg tgggtctgct     1200

agcgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg tgaaagagcc     1260

accctctcct gcagggccag tcagagtgtt agctacattg tttggtacca acagaaacct     1320

ggccaggcac ctaggctcct catctatgcc ccatccaacc tggcttctgg aataccagcc     1380

aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag tcttgagcct     1440

gaagattttg cagtttatta ctgtcagcag tggagtttta accctcccac gttcggccaa     1500

gggaccaagg tggaaatcaa atga                                            1524


<210>  399
<211>  508
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide DNE093 - VK3 leader through VK3


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (256)..(263)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (264)..(293)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (294)..(298)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (299)..(312)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (313)..(329)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (330)..(361)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (362)..(373)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (374)..(384)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (385)..(401)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (402)..(424)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (425)..(434)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (435)..(449)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (450)..(456)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (457)..(488)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (489)..(497)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (498)..(507)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (508)..(508)
<223>  Xaa is a stop codon

<400>  399

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
            260                 265                 270         


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
        275                 280                 285             


Gly Tyr Ser Phe Thr Ser Tyr Asn Met His Trp Val Arg Gln Met Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Tyr Pro Gly Asn Gly Asp 
305                 310                 315                 320 


Thr Ser Tyr Asn Gln Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp 
                325                 330                 335     


Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
            340                 345                 350         


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser Tyr Tyr Ser Asn Ser Tyr 
        355                 360                 365             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
385                 390                 395                 400 


Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
                405                 410                 415     


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr 
            420                 425                 430         


Ile Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        435                 440                 445             


Tyr Ala Pro Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    450                 455                 460                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
465                 470                 475                 480 


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro 
                485                 490                 495     


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Xaa 
            500                 505             


<210>  400
<211>  1539
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide DNE094 - human VK3 leader through VK3

<400>  400
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaggggtg tccaccttgt      780

ccgaattctg aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct      840

ctgaagattt cctgtaaggg atccggatac agctttacca gctacaacat gcactgggtg      900

cgccagatgc ccgggaaagg cctagagtgg atgggggcta tctatcctgg aaatggtgat      960

acatcctaca atcagaagtt caagggccag gtcactatct cggccgacaa gtccatcagc     1020

accgcctacc tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca     1080

cgcagctact atagtaactc ttactggtac ttcgatctct ggggccgcgg caccctggtc     1140

accgtctcct cggggggcgg tggatcgggc ggtggtggat ctggaggagg tgggtctggg     1200

ggcggtggat cggctagcga aattgtgttg acacagtctc cagccaccct gtctttgtct     1260

ccaggtgaaa gagccaccct ctcctgcagg gccagtcaga gtgttagcta cattgtttgg     1320

taccaacaga aacctggcca ggcacctagg ctcctcatct atgccccatc caacctggct     1380

tctggaatac cagccaggtt cagtggcagt ggatccggga cagacttcac tctcaccatc     1440

agcagtcttg agcctgaaga ttttgcagtt tattactgtc agcagtggag ttttaaccct     1500

cccacgttcg gccaagggac caaggtggaa atcaaatga                            1539


<210>  401
<211>  513
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide DNE094 - VK3 leader through VK3


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (256)..(263)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (264)..(293)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (294)..(298)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (299)..(312)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (313)..(329)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (330)..(361)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (362)..(373)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (374)..(384)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (385)..(406)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (407)..(429)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (430)..(439)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (440)..(454)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (455)..(461)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (462)..(493)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (494)..(502)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (503)..(512)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (513)..(513)
<223>  Xaa is a stop codon

<400>  401

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
            260                 265                 270         


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
        275                 280                 285             


Gly Tyr Ser Phe Thr Ser Tyr Asn Met His Trp Val Arg Gln Met Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Tyr Pro Gly Asn Gly Asp 
305                 310                 315                 320 


Thr Ser Tyr Asn Gln Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp 
                325                 330                 335     


Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
            340                 345                 350         


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser Tyr Tyr Ser Asn Ser Tyr 
        355                 360                 365             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Ala Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr 
                405                 410                 415     


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
            420                 425                 430         


Gln Ser Val Ser Tyr Ile Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        435                 440                 445             


Pro Arg Leu Leu Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Ile Pro 
    450                 455                 460                 


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
465                 470                 475                 480 


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp 
                485                 490                 495     


Ser Phe Asn Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            500                 505                 510         


Xaa 
    


<210>  402
<211>  1554
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide DNE095 - human VK3 leader through VK3

<400>  402
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaggggtg tccaccttgt      780

ccgaattctg aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct      840

ctgaagattt cctgtaaggg atccggatac agctttacca gctacaacat gcactgggtg      900

cgccagatgc ccgggaaagg cctagagtgg atgggggcta tctatcctgg aaatggtgat      960

acatcctaca atcagaagtt caagggccag gtcactatct cggccgacaa gtccatcagc     1020

accgcctacc tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca     1080

cgcagctact atagtaactc ttactggtac ttcgatctct ggggccgcgg caccctggtc     1140

accgtctcct cggggggcgg tggatcgggc ggtggtggat ctggaggagg tgggtctggg     1200

ggcggtggat cgggcggtgg tggatctgct agcgaaattg tgttgacaca gtctccagcc     1260

accctgtctt tgtctccagg tgaaagagcc accctctcct gcagggccag tcagagtgtt     1320

agctacattg tttggtacca acagaaacct ggccaggcac ctaggctcct catctatgcc     1380

ccatccaacc tggcttctgg aataccagcc aggttcagtg gcagtggatc cgggacagac     1440

ttcactctca ccatcagcag tcttgagcct gaagattttg cagtttatta ctgtcagcag     1500

tggagtttta accctcccac gttcggccaa gggaccaagg tggaaatcaa atga           1554


<210>  403
<211>  518
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide DNE095 - VK3 leader through VK3


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (256)..(263)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (264)..(293)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (294)..(298)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (299)..(312)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (313)..(329)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (330)..(361)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (362)..(373)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (374)..(384)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (385)..(411)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (412)..(434)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (435)..(444)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (445)..(459)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (460)..(466)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (467)..(498)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (499)..(507)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (508)..(517)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (518)..(518)
<223>  Xaa is a stop codon

<400>  403

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
            260                 265                 270         


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
        275                 280                 285             


Gly Tyr Ser Phe Thr Ser Tyr Asn Met His Trp Val Arg Gln Met Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Tyr Pro Gly Asn Gly Asp 
305                 310                 315                 320 


Thr Ser Tyr Asn Gln Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp 
                325                 330                 335     


Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
            340                 345                 350         


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser Tyr Tyr Ser Asn Ser Tyr 
        355                 360                 365             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Glu Ile Val Leu Thr 
                405                 410                 415     


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
            420                 425                 430         


Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Ile Val Trp Tyr Gln Gln 
        435                 440                 445             


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ala Pro Ser Asn Leu 
    450                 455                 460                 


Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
465                 470                 475                 480 


Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 
                485                 490                 495     


Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Gln Gly Thr 
            500                 505                 510         


Lys Val Glu Ile Lys Xaa 
        515             


<210>  404
<211>  1536
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0012 nucleotide sequence - full length 
       sequence

<400>  404
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaggggtg tccaccttgt      780

ccgaattctg aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct      840

ctgaagattt cctgtaaggg ctccggttac tcattcactg gctacaatat gaactgggtg      900

cgccagatgc ccgggaaagg ccttgagtgg atgggcaata ttgatcctta ttatggtggt      960

actacctaca accggaagtt caagggccag gtcactatct ccgccgacaa gtccatcagc     1020

accgcctacc tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca     1080

cgctcagtcg gccctttcga ctcctggggc cagggcaccc tggtcactgt ctcctctggg     1140

ggtggaggct ctggtggcgg tggctctggc ggaggtggat ccggtggcgg cggatctggc     1200

gggggtggct ctgaaattgt gttgacacag tctccagcca ccctgtcttt gtctccaggc     1260

gaaagagcca ccctctcctg ccgagcaagt gaaaatgttt acagctactt agcctggtac     1320

caacagaaac ctggccaggc tcctaggctc ctcatctatt ttgcaaaaac cttagcagaa     1380

ggtattccag ccaggttcag tggcagtggc tccgggacag acttcactct caccatcagc     1440

agcctagagc ctgaagattt tgcagtttat tactgtcaac atcattccga taatccgtgg     1500

acattcggcc aagggaccaa ggtggaaatc aaatga                               1536


<210>  405
<211>  512
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0012 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (256)..(263)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (264)..(288)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (289)..(296)
<223>  Heavy chain CDR sub-domaini

<220>
<221>  MISC_FEATURE
<222>  (297)..(321)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (322)..(328)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (329)..(359)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (360)..(368)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (369)..(379)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (380)..(404)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (405)..(430)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (431)..(436)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (437)..(456)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (457)..(469)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (470)..(492)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (493)..(501)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (502)..(511)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (512)..(512)
<223>  Xaa is a stop codon

<400>  405

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
            260                 265                 270         


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
        275                 280                 285             


Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr Gly Gly 
305                 310                 315                 320 


Thr Thr Tyr Asn Arg Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp 
                325                 330                 335     


Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
            340                 345                 350         


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser Val Gly Pro Phe Asp Ser 
        355                 360                 365             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
                405                 410                 415     


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn 
            420                 425                 430         


Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        435                 440                 445             


Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 
    450                 455                 460                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
465                 470                 475                 480 


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser 
                485                 490                 495     


Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Xaa 
            500                 505                 510         


<210>  406
<211>  1491
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0023 nucleotide sequence - full length 
       sequence

<400>  406
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaggggtg tccaccttgt      780

ccgaattctg aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct      840

ctgaagattt cctgtaaggg ctccggttac tcattcactg gctacaatat gaactgggtg      900

cgccagatgc ccgggaaagg ccttgagtgg atgggcaata ttgatcctta ttatggtggt      960

actacctaca accggaagtt caagggccag gtcactatct ccgccgacaa gtccatcagc     1020

accgcctacc tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca     1080

cgctcagtcg gccctttcga ctcctggggc cagggcaccc tggtcactgt ctcctctggg     1140

ggtggaggct ctggtggcgg tggatccgaa attgtgttga cacagtctcc agccaccctg     1200

tctttgtctc caggcgaaag agccaccctc tcctgccgag caagtgaaaa tgtttacagc     1260

tacttagcct ggtaccaaca gaaacctggc caggctccta ggctcctcat ctattttgca     1320

aaaaccttag cagaaggtat tccagccagg ttcagtggca gtggctccgg gacagacttc     1380

actctcacca tcagcagcct agagcctgaa gattttgcag tttattactg tcaacatcat     1440

tccgataatc cgtggacatt cggccaaggg accaaggtgg aaatcaaatg a              1491


<210>  407
<211>  497
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0023 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (256)..(263)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (264)..(288)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (289)..(296)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (297)..(321)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (322)..(328)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (329)..(359)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (360)..(368)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (369)..(379)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (380)..(389)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (390)..(415)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (416)..(421)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (422)..(441)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (442)..(454)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (455)..(477)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (478)..(486)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (487)..(496)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (497)..(497)
<223>  Xaa is a stop codon

<400>  407

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
            260                 265                 270         


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
        275                 280                 285             


Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr Gly Gly 
305                 310                 315                 320 


Thr Thr Tyr Asn Arg Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp 
                325                 330                 335     


Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
            340                 345                 350         


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser Val Gly Pro Phe Asp Ser 
        355                 360                 365             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
385                 390                 395                 400 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu 
                405                 410                 415     


Asn Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
            420                 425                 430         


Pro Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
    450                 455                 460                 


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His 
465                 470                 475                 480 


Ser Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                485                 490                 495     


Xaa 
    


<210>  408
<211>  1506
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0024 nucleotide sequence - full length 
       sequence

<400>  408
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaggggtg tccaccttgt      780

ccgaattctg aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct      840

ctgaagattt cctgtaaggg ctccggttac tcattcactg gctacaatat gaactgggtg      900

cgccagatgc ccgggaaagg ccttgagtgg atgggcaata ttgatcctta ttatggtggt      960

actacctaca accggaagtt caagggccag gtcactatct ccgccgacaa gtccatcagc     1020

accgcctacc tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca     1080

cgctcagtcg gccctttcga ctcctggggc cagggcaccc tggtcactgt ctcctctggg     1140

ggtggaggct ctggtggcgg tggctctggc ggaggtggat ccgaaattgt gttgacacag     1200

tctccagcca ccctgtcttt gtctccaggc gaaagagcca ccctctcctg ccgagcaagt     1260

gaaaatgttt acagctactt agcctggtac caacagaaac ctggccaggc tcctaggctc     1320

ctcatctatt ttgcaaaaac cttagcagaa ggtattccag ccaggttcag tggcagtggc     1380

tccgggacag acttcactct caccatcagc agcctagagc ctgaagattt tgcagtttat     1440

tactgtcaac atcattccga taatccgtgg acattcggcc aagggaccaa ggtggaaatc     1500

aaatga                                                                1506


<210>  409
<211>  502
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0024 amino sequence - full length sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (256)..(263)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (264)..(288)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (289)..(296)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (297)..(321)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (322)..(328)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (329)..(359)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (360)..(368)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (369)..(379)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (380)..(394)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (395)..(420)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (421)..(426)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (427)..(446)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (447)..(459)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (460)..(482)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (483)..(491)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (492)..(501)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (502)..(502)
<223>  Xaa is a stop codon

<400>  409

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
            260                 265                 270         


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
        275                 280                 285             


Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr Gly Gly 
305                 310                 315                 320 


Thr Thr Tyr Asn Arg Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp 
                325                 330                 335     


Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
            340                 345                 350         


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser Val Gly Pro Phe Asp Ser 
        355                 360                 365             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
385                 390                 395                 400 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
                405                 410                 415     


Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu 
        435                 440                 445             


Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    450                 455                 460                 


Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr 
                485                 490                 495     


Lys Val Glu Ile Lys Xaa 
            500         


<210>  410
<211>  1521
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0025 nucleotide sequence - full length 
       sequence

<400>  410
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaggggtg tccaccttgt      780

ccgaattctg aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct      840

ctgaagattt cctgtaaggg ctccggttac tcattcactg gctacaatat gaactgggtg      900

cgccagatgc ccgggaaagg ccttgagtgg atgggcaata ttgatcctta ttatggtggt      960

actacctaca accggaagtt caagggccag gtcactatct ccgccgacaa gtccatcagc     1020

accgcctacc tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca     1080

cgctcagtcg gccctttcga ctcctggggc cagggcaccc tggtcactgt ctcctctggg     1140

ggtggaggct ctggtggcgg tggatccggt ggcggcggat ctggcggggg tggctctgaa     1200

attgtgttga cacagtctcc agccaccctg tctttgtctc caggcgaaag agccaccctc     1260

tcctgccgag caagtgaaaa tgtttacagc tacttagcct ggtaccaaca gaaacctggc     1320

caggctccta ggctcctcat ctattttgca aaaaccttag cagaaggtat tccagccagg     1380

ttcagtggca gtggctccgg gacagacttc actctcacca tcagcagcct agagcctgaa     1440

gattttgcag tttattactg tcaacatcat tccgataatc cgtggacatt cggccaaggg     1500

accaaggtgg aaatcaaatg a                                               1521


<210>  411
<211>  507
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0025 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (256)..(263)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (264)..(288)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (289)..(296)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (297)..(321)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (322)..(328)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (329)..(359)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (360)..(368)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (369)..(379)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (380)..(399)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (400)..(425)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (426)..(431)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (432)..(451)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (452)..(464)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (465)..(487)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (488)..(496)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (497)..(506)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (507)..(507)
<223>  Xaa is a stop codon

<400>  411

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
            260                 265                 270         


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
        275                 280                 285             


Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr Gly Gly 
305                 310                 315                 320 


Thr Thr Tyr Asn Arg Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp 
                325                 330                 335     


Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
            340                 345                 350         


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser Val Gly Pro Phe Asp Ser 
        355                 360                 365             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu 
                405                 410                 415     


Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu 
            420                 425                 430         


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        435                 440                 445             


Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
465                 470                 475                 480 


Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr 
                485                 490                 495     


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Xaa 
            500                 505         


<210>  412
<211>  1530
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0062 nucleotide sequence - full length 
       sequence

<400>  412
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gttctccacc ttctccgaat      780

tctgaggtgc agctggtgca gtctggagca gaggtgaaaa agcccggaga gtctctgaag      840

atttcctgta agggctccgg ttactcattc actggctaca atatgaactg ggtgcgccag      900

atgcccggga aaggccttga gtggatgggc aatattgatc cttattatgg tggtactacc      960

tacaaccgga agttcaaggg ccaggtcact atctccgccg acaagtccat cagcaccgcc     1020

tacctgcaat ggagcagcct gaaggcctcg gacaccgcca tgtattactg tgcacgctca     1080

gtcggccctt tcgactcctg gggccagggc accctggtca ctgtctcctc tgggggtgga     1140

ggctctggtg gcggtggctc tggcggaggt ggatccggtg gcggcggatc tggcgggggt     1200

ggctctgaaa ttgtgttgac acagtctcca gccaccctgt ctttgtctcc aggcgaaaga     1260

gccaccctct cctgccgagc aagtgaaaat gtttacagct acttagcctg gtaccaacag     1320

aaacctggcc aggctcctag gctcctcatc tattttgcaa aaaccttagc agaaggtatt     1380

ccagccaggt tcagtggcag tggctccggg acagacttca ctctcaccat cagcagccta     1440

gagcctgaag attttgcagt ttattactgt caacatcatt ccgataatcc gtggacattc     1500

ggccaaggga ccaaggtgga aatcaaatga                                      1530


<210>  413
<211>  510
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0062 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(261)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (262)..(286)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (287)..(294)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (295)..(319)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (320)..(326)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (327)..(357)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (358)..(366)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (367)..(377)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (378)..(402)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (403)..(428)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (429)..(434)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (435)..(454)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (455)..(467)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (468)..(490)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (491)..(499)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (500)..(509)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (510)..(510)
<223>  Xaa is a stop codon

<400>  413

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Pro 
                245                 250                 255     


Pro Ser Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            260                 265                 270         


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
        275                 280                 285             


Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys 
    290                 295                 300                 


Gly Leu Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr 
305                 310                 315                 320 


Tyr Asn Arg Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
                325                 330                 335     


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
            340                 345                 350         


Ala Met Tyr Tyr Cys Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly 
        355                 360                 365             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
                405                 410                 415     


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr 
            420                 425                 430         


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        435                 440                 445             


Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe 
    450                 455                 460                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
465                 470                 475                 480 


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn 
                485                 490                 495     


Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Xaa 
            500                 505                 510 


<210>  414
<211>  1554
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0063 nucleotide sequence - full length 
       sequence

<400>  414
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtctgtctgt gaaagctgac      780

ttcctcactc catccatcgg gaattctgag gtgcagctgg tgcagtctgg agcagaggtg      840

aaaaagcccg gagagtctct gaagatttcc tgtaagggct ccggttactc attcactggc      900

tacaatatga actgggtgcg ccagatgccc gggaaaggcc ttgagtggat gggcaatatt      960

gatccttatt atggtggtac tacctacaac cggaagttca agggccaggt cactatctcc     1020

gccgacaagt ccatcagcac cgcctacctg caatggagca gcctgaaggc ctcggacacc     1080

gccatgtatt actgtgcacg ctcagtcggc cctttcgact cctggggcca gggcaccctg     1140

gtcactgtct cctctggggg tggaggctct ggtggcggtg gctctggcgg aggtggatcc     1200

ggtggcggcg gatctggcgg gggtggctct gaaattgtgt tgacacagtc tccagccacc     1260

ctgtctttgt ctccaggcga aagagccacc ctctcctgcc gagcaagtga aaatgtttac     1320

agctacttag cctggtacca acagaaacct ggccaggctc ctaggctcct catctatttt     1380

gcaaaaacct tagcagaagg tattccagcc aggttcagtg gcagtggctc cgggacagac     1440

ttcactctca ccatcagcag cctagagcct gaagattttg cagtttatta ctgtcaacat     1500

cattccgata atccgtggac attcggccaa gggaccaagg tggaaatcaa atga           1554


<210>  415
<211>  518
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0063 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(269)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (270)..(294)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (295)..(302)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (303)..(327)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (328)..(334)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (335)..(365)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (366)..(374)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (375)..(385)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (386)..(410)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (411)..(436)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (437)..(442)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (443)..(462)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (463)..(475)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (476)..(498)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (499)..(507)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (508)..(517)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (518)..(518)
<223>  Xaa is a stop codon

<400>  415

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Leu Ser 
                245                 250                 255     


Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser Glu Val Gln 
            260                 265                 270         


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys 
        275                 280                 285             


Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn 
    290                 295                 300                 


Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Asn Ile 
305                 310                 315                 320 


Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys Gly Gln 
                325                 330                 335     


Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp 
            340                 345                 350         


Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser 
        355                 360                 365             


Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
                405                 410                 415     


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
            420                 425                 430         


Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln 
        435                 440                 445             


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu 
    450                 455                 460                 


Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
465                 470                 475                 480 


Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 
                485                 490                 495     


Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr 
            500                 505                 510         


Lys Val Glu Ile Lys Xaa 
        515             


<210>  416
<211>  1545
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0064 nucleotide sequence - full length 
       sequence

<400>  416
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagatgaa ctccgagttg      780

agcgtgctcg cgaattctga ggtgcagctg gtgcagtctg gagcagaggt gaaaaagccc      840

ggagagtctc tgaagatttc ctgtaagggc tccggttact cattcactgg ctacaatatg      900

aactgggtgc gccagatgcc cgggaaaggc cttgagtgga tgggcaatat tgatccttat      960

tatggtggta ctacctacaa ccggaagttc aagggccagg tcactatctc cgccgacaag     1020

tccatcagca ccgcctacct gcaatggagc agcctgaagg cctcggacac cgccatgtat     1080

tactgtgcac gctcagtcgg ccctttcgac tcctggggcc agggcaccct ggtcactgtc     1140

tcctctgggg gtggaggctc tggtggcggt ggctctggcg gaggtggatc cggtggcggc     1200

ggatctggcg ggggtggctc tgaaattgtg ttgacacagt ctccagccac cctgtctttg     1260

tctccaggcg aaagagccac cctctcctgc cgagcaagtg aaaatgttta cagctactta     1320

gcctggtacc aacagaaacc tggccaggct cctaggctcc tcatctattt tgcaaaaacc     1380

ttagcagaag gtattccagc caggttcagt ggcagtggct ccgggacaga cttcactctc     1440

accatcagca gcctagagcc tgaagatttt gcagtttatt actgtcaaca tcattccgat     1500

aatccgtgga cattcggcca agggaccaag gtggaaatca aatga                     1545


<210>  417
<211>  515
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0064 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(266)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (267)..(291)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (292)..(299)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (300)..(324)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (325)..(331)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (332)..(362)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (363)..(371)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (372)..(382)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (383)..(407)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (408)..(433)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (434)..(439)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (440)..(459)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (460)..(472)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (473)..(495)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (496)..(504)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (505)..(514)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (515)..(515)
<223>  Xaa is a stop codon

<400>  417

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Met 
                245                 250                 255     


Asn Ser Glu Leu Ser Val Leu Ala Asn Ser Glu Val Gln Leu Val Gln 
            260                 265                 270         


Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys 
        275                 280                 285             


Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg 
    290                 295                 300                 


Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Asn Ile Asp Pro Tyr 
305                 310                 315                 320 


Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys Gly Gln Val Thr Ile 
                325                 330                 335     


Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu 
            340                 345                 350         


Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser Val Gly Pro 
        355                 360                 365             


Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
                405                 410                 415     


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
            420                 425                 430         


Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
        435                 440                 445             


Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly 
    450                 455                 460                 


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
465                 470                 475                 480 


Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
                485                 490                 495     


His His Ser Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu 
            500                 505                 510         


Ile Lys Xaa 
        515 


<210>  418
<211>  1572
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0065 nucleotide sequence - full length 
       sequence

<400>  418
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct      780

tccctgaata caagaactca gaaagcacgt cattgtccga attctgaggt gcagctggtg      840

cagtctggag cagaggtgaa aaagcccgga gagtctctga agatttcctg taagggctcc      900

ggttactcat tcactggcta caatatgaac tgggtgcgcc agatgcccgg gaaaggcctt      960

gagtggatgg gcaatattga tccttattat ggtggtacta cctacaaccg gaagttcaag     1020

ggccaggtca ctatctccgc cgacaagtcc atcagcaccg cctacctgca atggagcagc     1080

ctgaaggcct cggacaccgc catgtattac tgtgcacgct cagtcggccc tttcgactcc     1140

tggggccagg gcaccctggt cactgtctcc tctgggggtg gaggctctgg tggcggtggc     1200

tctggcggag gtggatccgg tggcggcgga tctggcgggg gtggctctga aattgtgttg     1260

acacagtctc cagccaccct gtctttgtct ccaggcgaaa gagccaccct ctcctgccga     1320

gcaagtgaaa atgtttacag ctacttagcc tggtaccaac agaaacctgg ccaggctcct     1380

aggctcctca tctattttgc aaaaacctta gcagaaggta ttccagccag gttcagtggc     1440

agtggctccg ggacagactt cactctcacc atcagcagcc tagagcctga agattttgca     1500

gtttattact gtcaacatca ttccgataat ccgtggacat tcggccaagg gaccaaggtg     1560

gaaatcaaat ga                                                         1572


<210>  419
<211>  524
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0065 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(275)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (276)..(300)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (301)..(308)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (309)..(333)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (334)..(340)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (341)..(371)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (372)..(380)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (381)..(391)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (392)..(416)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (417)..(442)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (443)..(448)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (449)..(468)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (469)..(481)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (482)..(504)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (505)..(513)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (514)..(523)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (524)..(524)
<223>  Xaa is a stop codon

<400>  419

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg 
                245                 250                 255     


His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg His Cys 
            260                 265                 270         


Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        275                 280                 285             


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
    290                 295                 300                 


Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn 
                325                 330                 335     


Arg Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
            420                 425                 430         


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr 
        435                 440                 445             


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
    450                 455                 460                 


Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly 
465                 470                 475                 480 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
                485                 490                 495     


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp 
            500                 505                 510         


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Xaa 
        515                 520                 


<210>  420
<211>  1485
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0066 nucleotide sequence - full length 
       sequence

<400>  420
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gttctccacc ttctccgaat      780

tctgaggtgc agctggtgca gtctggagca gaggtgaaaa agcccggaga gtctctgaag      840

atttcctgta agggctccgg ttactcattc actggctaca atatgaactg ggtgcgccag      900

atgcccggga aaggccttga gtggatgggc aatattgatc cttattatgg tggtactacc      960

tacaaccgga agttcaaggg ccaggtcact atctccgccg acaagtccat cagcaccgcc     1020

tacctgcaat ggagcagcct gaaggcctcg gacaccgcca tgtattactg tgcacgctca     1080

gtcggccctt tcgactcctg gggccagggc accctggtca ctgtctcctc tgggggtgga     1140

ggctctggtg gcggtggatc cgaaattgtg ttgacacagt ctccagccac cctgtctttg     1200

tctccaggcg aaagagccac cctctcctgc cgagcaagtg aaaatgttta cagctactta     1260

gcctggtacc aacagaaacc tggccaggct cctaggctcc tcatctattt tgcaaaaacc     1320

ttagcagaag gtattccagc caggttcagt ggcagtggct ccgggacaga cttcactctc     1380

accatcagca gcctagagcc tgaagatttt gcagtttatt actgtcaaca tcattccgat     1440

aatccgtgga cattcggcca agggaccaag gtggaaatca aatga                     1485


<210>  421
<211>  495
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0066 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(261)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (262)..(286)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (287)..(294)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (295)..(319)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (320)..(326)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (327)..(357)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (358)..(366)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (367)..(377)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (378)..(387)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (388)..(413)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (414)..(419)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (420)..(439)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (440)..(452)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (453)..(475)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (476)..(484)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (485)..(494)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (495)..(495)
<223>  Xaa is a stop codon

<400>  421

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Pro 
                245                 250                 255     


Pro Ser Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            260                 265                 270         


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
        275                 280                 285             


Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys 
    290                 295                 300                 


Gly Leu Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr 
305                 310                 315                 320 


Tyr Asn Arg Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
                325                 330                 335     


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
            340                 345                 350         


Ala Met Tyr Tyr Cys Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly 
        355                 360                 365             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
385                 390                 395                 400 


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val 
                405                 410                 415     


Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
            420                 425                 430         


Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg 
        435                 440                 445             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
    450                 455                 460                 


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser Asp 
465                 470                 475                 480 


Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Xaa 
                485                 490                 495 


<210>  422
<211>  1509
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0067 nucleotide sequence - full length 
       sequence

<400>  422
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtctgtctgt gaaagctgac      780

ttcctcactc catccatcgg gaattctgag gtgcagctgg tgcagtctgg agcagaggtg      840

aaaaagcccg gagagtctct gaagatttcc tgtaagggct ccggttactc attcactggc      900

tacaatatga actgggtgcg ccagatgccc gggaaaggcc ttgagtggat gggcaatatt      960

gatccttatt atggtggtac tacctacaac cggaagttca agggccaggt cactatctcc     1020

gccgacaagt ccatcagcac cgcctacctg caatggagca gcctgaaggc ctcggacacc     1080

gccatgtatt actgtgcacg ctcagtcggc cctttcgact cctggggcca gggcaccctg     1140

gtcactgtct cctctggggg tggaggctct ggtggcggtg gatccgaaat tgtgttgaca     1200

cagtctccag ccaccctgtc tttgtctcca ggcgaaagag ccaccctctc ctgccgagca     1260

agtgaaaatg tttacagcta cttagcctgg taccaacaga aacctggcca ggctcctagg     1320

ctcctcatct attttgcaaa aaccttagca gaaggtattc cagccaggtt cagtggcagt     1380

ggctccggga cagacttcac tctcaccatc agcagcctag agcctgaaga ttttgcagtt     1440

tattactgtc aacatcattc cgataatccg tggacattcg gccaagggac caaggtggaa     1500

atcaaatga                                                             1509


<210>  423
<211>  503
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0067 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(269)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (270)..(294)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (295)..(302)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (303)..(327)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (328)..(334)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (335)..(365)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (366)..(374)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (375)..(385)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (386)..(395)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (396)..(421)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (422)..(427)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (428)..(447)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (448)..(460)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (461)..(483)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (484)..(492)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (493)..(502)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (503)..(503)
<223>  Xaa is a stop codon

<400>  423

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Leu Ser 
                245                 250                 255     


Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser Glu Val Gln 
            260                 265                 270         


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys 
        275                 280                 285             


Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn 
    290                 295                 300                 


Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Asn Ile 
305                 310                 315                 320 


Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys Gly Gln 
                325                 330                 335     


Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp 
            340                 345                 350         


Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser 
        355                 360                 365             


Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
385                 390                 395                 400 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
                405                 410                 415     


Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp Tyr Gln 
            420                 425                 430         


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala Lys Thr 
        435                 440                 445             


Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    450                 455                 460                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly Gln Gly 
                485                 490                 495     


Thr Lys Val Glu Ile Lys Xaa 
            500             


<210>  424
<211>  1500
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0068 nucleotide sequence - full length 
       sequence

<400>  424
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagatgaa ctccgagttg      780

agcgtgctcg cgaattctga ggtgcagctg gtgcagtctg gagcagaggt gaaaaagccc      840

ggagagtctc tgaagatttc ctgtaagggc tccggttact cattcactgg ctacaatatg      900

aactgggtgc gccagatgcc cgggaaaggc cttgagtgga tgggcaatat tgatccttat      960

tatggtggta ctacctacaa ccggaagttc aagggccagg tcactatctc cgccgacaag     1020

tccatcagca ccgcctacct gcaatggagc agcctgaagg cctcggacac cgccatgtat     1080

tactgtgcac gctcagtcgg ccctttcgac tcctggggcc agggcaccct ggtcactgtc     1140

tcctctgggg gtggaggctc tggtggcggt ggatccgaaa ttgtgttgac acagtctcca     1200

gccaccctgt ctttgtctcc aggcgaaaga gccaccctct cctgccgagc aagtgaaaat     1260

gtttacagct acttagcctg gtaccaacag aaacctggcc aggctcctag gctcctcatc     1320

tattttgcaa aaaccttagc agaaggtatt ccagccaggt tcagtggcag tggctccggg     1380

acagacttca ctctcaccat cagcagccta gagcctgaag attttgcagt ttattactgt     1440

caacatcatt ccgataatcc gtggacattc ggccaaggga ccaaggtgga aatcaaatga     1500


<210>  425
<211>  500
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0068 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(266)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (267)..(291)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (292)..(299)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (300)..(324)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (325)..(331)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (332)..(362)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (363)..(371)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (372)..(382)
<223>  Heavy  region

<220>
<221>  MISC_FEATURE
<222>  (383)..(392)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (393)..(418)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (419)..(424)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (425)..(444)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (445)..(457)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (458)..(480)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (481)..(489)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (490)..(499)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (500)..(500)
<223>  Xaa is a stop codon

<400>  425

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Met 
                245                 250                 255     


Asn Ser Glu Leu Ser Val Leu Ala Asn Ser Glu Val Gln Leu Val Gln 
            260                 265                 270         


Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys 
        275                 280                 285             


Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg 
    290                 295                 300                 


Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Asn Ile Asp Pro Tyr 
305                 310                 315                 320 


Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys Gly Gln Val Thr Ile 
                325                 330                 335     


Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu 
            340                 345                 350         


Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser Val Gly Pro 
        355                 360                 365             


Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 
385                 390                 395                 400 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
                405                 410                 415     


Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu 
        435                 440                 445             


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Gln His His Ser Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Xaa 
            500 


<210>  426
<211>  1527
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0069 nucleotide sequence - full length 
       sequence

<400>  426
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct      780

tccctgaata caagaactca gaaagcacgt cattgtccga attctgaggt gcagctggtg      840

cagtctggag cagaggtgaa aaagcccgga gagtctctga agatttcctg taagggctcc      900

ggttactcat tcactggcta caatatgaac tgggtgcgcc agatgcccgg gaaaggcctt      960

gagtggatgg gcaatattga tccttattat ggtggtacta cctacaaccg gaagttcaag     1020

ggccaggtca ctatctccgc cgacaagtcc atcagcaccg cctacctgca atggagcagc     1080

ctgaaggcct cggacaccgc catgtattac tgtgcacgct cagtcggccc tttcgactcc     1140

tggggccagg gcaccctggt cactgtctcc tctgggggtg gaggctctgg tggcggtgga     1200

tccgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc     1260

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa     1320

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca     1380

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag     1440

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc     1500

caagggacca aggtggaaat caaatga                                         1527


<210>  427
<211>  509
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0069 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(275)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (276)..(300)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (301)..(308)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (309)..(333)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (334)..(340)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (341)..(371)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (372)..(380)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (381)..(391)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (392)..(401)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (402)..(427)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (428)..(433)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (434)..(453)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (454)..(466)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (467)..(489)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (490)..(498)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (499)..(508)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (509)..(509)
<223>  Xaa is a stop codon

<400>  427

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg 
                245                 250                 255     


His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg His Cys 
            260                 265                 270         


Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        275                 280                 285             


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
    290                 295                 300                 


Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn 
                325                 330                 335     


Arg Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
                405                 410                 415     


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser 
            420                 425                 430         


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        435                 440                 445             


Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser 
    450                 455                 460                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
465                 470                 475                 480 


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro 
                485                 490                 495     


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Xaa 
            500                 505                 


<210>  428
<211>  1500
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0070 nucleotide sequence - full length 
       sequence

<400>  428
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gttctccacc ttctccgaat      780

tctgaggtgc agctggtgca gtctggagca gaggtgaaaa agcccggaga gtctctgaag      840

atttcctgta agggctccgg ttactcattc actggctaca atatgaactg ggtgcgccag      900

atgcccggga aaggccttga gtggatgggc aatattgatc cttattatgg tggtactacc      960

tacaaccgga agttcaaggg ccaggtcact atctccgccg acaagtccat cagcaccgcc     1020

tacctgcaat ggagcagcct gaaggcctcg gacaccgcca tgtattactg tgcacgctca     1080

gtcggccctt tcgactcctg gggccagggc accctggtca ctgtctcctc tgggggtgga     1140

ggctctggtg gcggtggctc tggcggaggt ggatccgaaa ttgtgttgac acagtctcca     1200

gccaccctgt ctttgtctcc aggcgaaaga gccaccctct cctgccgagc aagtgaaaat     1260

gtttacagct acttagcctg gtaccaacag aaacctggcc aggctcctag gctcctcatc     1320

tattttgcaa aaaccttagc agaaggtatt ccagccaggt tcagtggcag tggctccggg     1380

acagacttca ctctcaccat cagcagccta gagcctgaag attttgcagt ttattactgt     1440

caacatcatt ccgataatcc gtggacattc ggccaaggga ccaaggtgga aatcaaatga     1500


<210>  429
<211>  500
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0070 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(261)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (262)..(286)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (287)..(294)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (295)..(319)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (320)..(326)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (327)..(357)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (358)..(366)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (367)..(377)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (378)..(392)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (393)..(418)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (419)..(424)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (425)..(444)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (445)..(457)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (458)..(480)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (481)..(489)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (490)..(499)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (500)..(500)
<223>  Xaa is a stop codon

<400>  429

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Pro 
                245                 250                 255     


Pro Ser Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            260                 265                 270         


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
        275                 280                 285             


Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys 
    290                 295                 300                 


Gly Leu Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr 
305                 310                 315                 320 


Tyr Asn Arg Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
                325                 330                 335     


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
            340                 345                 350         


Ala Met Tyr Tyr Cys Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly 
        355                 360                 365             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 
385                 390                 395                 400 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
                405                 410                 415     


Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu 
        435                 440                 445             


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Gln His His Ser Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Xaa 
            500 


<210>  430
<211>  1524
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0071 nucleotide sequence - full length 
       sequence

<400>  430
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtctgtctgt gaaagctgac      780

ttcctcactc catccatcgg gaattctgag gtgcagctgg tgcagtctgg agcagaggtg      840

aaaaagcccg gagagtctct gaagatttcc tgtaagggct ccggttactc attcactggc      900

tacaatatga actgggtgcg ccagatgccc gggaaaggcc ttgagtggat gggcaatatt      960

gatccttatt atggtggtac tacctacaac cggaagttca agggccaggt cactatctcc     1020

gccgacaagt ccatcagcac cgcctacctg caatggagca gcctgaaggc ctcggacacc     1080

gccatgtatt actgtgcacg ctcagtcggc cctttcgact cctggggcca gggcaccctg     1140

gtcactgtct cctctggggg tggaggctct ggtggcggtg gctctggcgg aggtggatcc     1200

gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccaggcga aagagccacc     1260

ctctcctgcc gagcaagtga aaatgtttac agctacttag cctggtacca acagaaacct     1320

ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg tattccagcc     1380

aggttcagtg gcagtggctc cgggacagac ttcactctca ccatcagcag cctagagcct     1440

gaagattttg cagtttatta ctgtcaacat cattccgata atccgtggac attcggccaa     1500

gggaccaagg tggaaatcaa atga                                            1524


<210>  431
<211>  508
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0071 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(269)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (270)..(294)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (295)..(302)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (303)..(327)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (328)..(334)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (335)..(365)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (366)..(374)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (375)..(385)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (386)..(400)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (401)..(426)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (427)..(432)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (433)..(452)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (453)..(465)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (466)..(488)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (489)..(497)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (498)..(507)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (508)..(508)
<223>  Xaa is a stop codon

<400>  431

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Leu Ser 
                245                 250                 255     


Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser Glu Val Gln 
            260                 265                 270         


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys 
        275                 280                 285             


Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn 
    290                 295                 300                 


Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Asn Ile 
305                 310                 315                 320 


Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys Gly Gln 
                325                 330                 335     


Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp 
            340                 345                 350         


Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser 
        355                 360                 365             


Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
                405                 410                 415     


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr 
            420                 425                 430         


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        435                 440                 445             


Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly 
    450                 455                 460                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
465                 470                 475                 480 


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp 
                485                 490                 495     


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Xaa 
            500                 505             


<210>  432
<211>  1515
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0072 nucleotide sequence - full length 
       sequence

<400>  432
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagatgaa ctccgagttg      780

agcgtgctcg cgaattctga ggtgcagctg gtgcagtctg gagcagaggt gaaaaagccc      840

ggagagtctc tgaagatttc ctgtaagggc tccggttact cattcactgg ctacaatatg      900

aactgggtgc gccagatgcc cgggaaaggc cttgagtgga tgggcaatat tgatccttat      960

tatggtggta ctacctacaa ccggaagttc aagggccagg tcactatctc cgccgacaag     1020

tccatcagca ccgcctacct gcaatggagc agcctgaagg cctcggacac cgccatgtat     1080

tactgtgcac gctcagtcgg ccctttcgac tcctggggcc agggcaccct ggtcactgtc     1140

tcctctgggg gtggaggctc tggtggcggt ggctctggcg gaggtggatc cgaaattgtg     1200

ttgacacagt ctccagccac cctgtctttg tctccaggcg aaagagccac cctctcctgc     1260

cgagcaagtg aaaatgttta cagctactta gcctggtacc aacagaaacc tggccaggct     1320

cctaggctcc tcatctattt tgcaaaaacc ttagcagaag gtattccagc caggttcagt     1380

ggcagtggct ccgggacaga cttcactctc accatcagca gcctagagcc tgaagatttt     1440

gcagtttatt actgtcaaca tcattccgat aatccgtgga cattcggcca agggaccaag     1500

gtggaaatca aatga                                                      1515


<210>  433
<211>  505
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0072 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(266)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (267)..(291)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (292)..(299)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (300)..(324)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (325)..(331)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (332)..(362)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (363)..(371)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (372)..(382)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (383)..(397)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (398)..(423)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (424)..(429)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (430)..(449)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (450)..(462)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (463)..(485)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (486)..(494)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (495)..(504)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (505)..(505)
<223>  Xaa is a stop codon

<400>  433

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Met 
                245                 250                 255     


Asn Ser Glu Leu Ser Val Leu Ala Asn Ser Glu Val Gln Leu Val Gln 
            260                 265                 270         


Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys 
        275                 280                 285             


Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg 
    290                 295                 300                 


Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Asn Ile Asp Pro Tyr 
305                 310                 315                 320 


Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys Gly Gln Val Thr Ile 
                325                 330                 335     


Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu 
            340                 345                 350         


Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser Val Gly Pro 
        355                 360                 365             


Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
385                 390                 395                 400 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
                405                 410                 415     


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
            420                 425                 430         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
        435                 440                 445             


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    450                 455                 460                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
465                 470                 475                 480 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
                485                 490                 495     


Gln Gly Thr Lys Val Glu Ile Lys Xaa 
            500                 505 


<210>  434
<211>  1542
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0073 nucleotide sequence - full length 
       sequence

<400>  434
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct      780

tccctgaata caagaactca gaaagcacgt cattgtccga attctgaggt gcagctggtg      840

cagtctggag cagaggtgaa aaagcccgga gagtctctga agatttcctg taagggctcc      900

ggttactcat tcactggcta caatatgaac tgggtgcgcc agatgcccgg gaaaggcctt      960

gagtggatgg gcaatattga tccttattat ggtggtacta cctacaaccg gaagttcaag     1020

ggccaggtca ctatctccgc cgacaagtcc atcagcaccg cctacctgca atggagcagc     1080

ctgaaggcct cggacaccgc catgtattac tgtgcacgct cagtcggccc tttcgactcc     1140

tggggccagg gcaccctggt cactgtctcc tctgggggtg gaggctctgg tggcggtggc     1200

tctggcggag gtggatccga aattgtgttg acacagtctc cagccaccct gtctttgtct     1260

ccaggcgaaa gagccaccct ctcctgccga gcaagtgaaa atgtttacag ctacttagcc     1320

tggtaccaac agaaacctgg ccaggctcct aggctcctca tctattttgc aaaaacctta     1380

gcagaaggta ttccagccag gttcagtggc agtggctccg ggacagactt cactctcacc     1440

atcagcagcc tagagcctga agattttgca gtttattact gtcaacatca ttccgataat     1500

ccgtggacat tcggccaagg gaccaaggtg gaaatcaaat ga                        1542


<210>  435
<211>  514
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0073 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(275)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (276)..(300)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (301)..(308)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (309)..(333)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (334)..(340)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (341)..(371)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (372)..(380)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (381)..(391)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (392)..(406)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (407)..(432)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (433)..(438)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (439)..(458)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (459)..(471)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (472)..(494)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (495)..(503)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (504)..(513)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (514)..(514)
<223>  Xaa is a stop codon

<400>  435

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg 
                245                 250                 255     


His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg His Cys 
            260                 265                 270         


Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        275                 280                 285             


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
    290                 295                 300                 


Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn 
                325                 330                 335     


Arg Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr 
                405                 410                 415     


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
            420                 425                 430         


Glu Asn Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        435                 440                 445             


Ala Pro Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile 
    450                 455                 460                 


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
465                 470                 475                 480 


Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His 
                485                 490                 495     


His Ser Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            500                 505                 510         


Lys Xaa 
        


<210>  436
<211>  1515
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0074 nucleotide sequence - full length 
       sequence

<400>  436
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gttctccacc ttctccgaat      780

tctgaggtgc agctggtgca gtctggagca gaggtgaaaa agcccggaga gtctctgaag      840

atttcctgta agggctccgg ttactcattc actggctaca atatgaactg ggtgcgccag      900

atgcccggga aaggccttga gtggatgggc aatattgatc cttattatgg tggtactacc      960

tacaaccgga agttcaaggg ccaggtcact atctccgccg acaagtccat cagcaccgcc     1020

tacctgcaat ggagcagcct gaaggcctcg gacaccgcca tgtattactg tgcacgctca     1080

gtcggccctt tcgactcctg gggccagggc accctggtca ctgtctcctc tgggggtgga     1140

ggctctggtg gcggtggatc cggtggcggc ggatctggcg ggggtggctc tgaaattgtg     1200

ttgacacagt ctccagccac cctgtctttg tctccaggcg aaagagccac cctctcctgc     1260

cgagcaagtg aaaatgttta cagctactta gcctggtacc aacagaaacc tggccaggct     1320

cctaggctcc tcatctattt tgcaaaaacc ttagcagaag gtattccagc caggttcagt     1380

ggcagtggct ccgggacaga cttcactctc accatcagca gcctagagcc tgaagatttt     1440

gcagtttatt actgtcaaca tcattccgat aatccgtgga cattcggcca agggaccaag     1500

gtggaaatca aatga                                                      1515


<210>  437
<211>  505
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0074 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(261)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (262)..(286)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (287)..(294)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (295)..(319)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (320)..(326)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (327)..(357)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (358)..(366)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (367)..(377)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (378)..(397)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (398)..(423)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (424)..(429)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (430)..(449)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (450)..(462)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (463)..(485)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (486)..(494)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (495)..(504)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (505)..(505)
<223>  Xaa is a stop codon

<400>  437

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Pro 
                245                 250                 255     


Pro Ser Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            260                 265                 270         


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
        275                 280                 285             


Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys 
    290                 295                 300                 


Gly Leu Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr 
305                 310                 315                 320 


Tyr Asn Arg Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
                325                 330                 335     


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
            340                 345                 350         


Ala Met Tyr Tyr Cys Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly 
        355                 360                 365             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
385                 390                 395                 400 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
                405                 410                 415     


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
            420                 425                 430         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
        435                 440                 445             


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    450                 455                 460                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
465                 470                 475                 480 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
                485                 490                 495     


Gln Gly Thr Lys Val Glu Ile Lys Xaa 
            500                 505 


<210>  438
<211>  1539
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0075 nucleotide sequence - full length 
       sequence

<400>  438
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtctgtctgt gaaagctgac      780

ttcctcactc catccatcgg gaattctgag gtgcagctgg tgcagtctgg agcagaggtg      840

aaaaagcccg gagagtctct gaagatttcc tgtaagggct ccggttactc attcactggc      900

tacaatatga actgggtgcg ccagatgccc gggaaaggcc ttgagtggat gggcaatatt      960

gatccttatt atggtggtac tacctacaac cggaagttca agggccaggt cactatctcc     1020

gccgacaagt ccatcagcac cgcctacctg caatggagca gcctgaaggc ctcggacacc     1080

gccatgtatt actgtgcacg ctcagtcggc cctttcgact cctggggcca gggcaccctg     1140

gtcactgtct cctctggggg tggaggctct ggtggcggtg gatccggtgg cggcggatct     1200

ggcgggggtg gctctgaaat tgtgttgaca cagtctccag ccaccctgtc tttgtctcca     1260

ggcgaaagag ccaccctctc ctgccgagca agtgaaaatg tttacagcta cttagcctgg     1320

taccaacaga aacctggcca ggctcctagg ctcctcatct attttgcaaa aaccttagca     1380

gaaggtattc cagccaggtt cagtggcagt ggctccggga cagacttcac tctcaccatc     1440

agcagcctag agcctgaaga ttttgcagtt tattactgtc aacatcattc cgataatccg     1500

tggacattcg gccaagggac caaggtggaa atcaaatga                            1539


<210>  439
<211>  513
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0075 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(269)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (270)..(294)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (295)..(302)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (303)..(327)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (328)..(334)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (335)..(365)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (366)..(374)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (375)..(385)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (386)..(405)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (406)..(431)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (432)..(437)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (438)..(457)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (458)..(470)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (471)..(493)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (494)..(502)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (503)..(512)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (513)..(513)
<223>  Xaa is a stop codon

<400>  439

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Leu Ser 
                245                 250                 255     


Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser Glu Val Gln 
            260                 265                 270         


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys 
        275                 280                 285             


Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn 
    290                 295                 300                 


Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Asn Ile 
305                 310                 315                 320 


Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys Gly Gln 
                325                 330                 335     


Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp 
            340                 345                 350         


Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser 
        355                 360                 365             


Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
                405                 410                 415     


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu 
            420                 425                 430         


Asn Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        435                 440                 445             


Pro Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro 
    450                 455                 460                 


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
465                 470                 475                 480 


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His 
                485                 490                 495     


Ser Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            500                 505                 510         


Xaa 
    


<210>  440
<211>  1530
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0076 nucleotide sequence - full length 
       sequence

<400>  440
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagatgaa ctccgagttg      780

agcgtgctcg cgaattctga ggtgcagctg gtgcagtctg gagcagaggt gaaaaagccc      840

ggagagtctc tgaagatttc ctgtaagggc tccggttact cattcactgg ctacaatatg      900

aactgggtgc gccagatgcc cgggaaaggc cttgagtgga tgggcaatat tgatccttat      960

tatggtggta ctacctacaa ccggaagttc aagggccagg tcactatctc cgccgacaag     1020

tccatcagca ccgcctacct gcaatggagc agcctgaagg cctcggacac cgccatgtat     1080

tactgtgcac gctcagtcgg ccctttcgac tcctggggcc agggcaccct ggtcactgtc     1140

tcctctgggg gtggaggctc tggtggcggt ggatccggtg gcggcggatc tggcgggggt     1200

ggctctgaaa ttgtgttgac acagtctcca gccaccctgt ctttgtctcc aggcgaaaga     1260

gccaccctct cctgccgagc aagtgaaaat gtttacagct acttagcctg gtaccaacag     1320

aaacctggcc aggctcctag gctcctcatc tattttgcaa aaaccttagc agaaggtatt     1380

ccagccaggt tcagtggcag tggctccggg acagacttca ctctcaccat cagcagccta     1440

gagcctgaag attttgcagt ttattactgt caacatcatt ccgataatcc gtggacattc     1500

ggccaaggga ccaaggtgga aatcaaatga                                      1530


<210>  441
<211>  510
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0076 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(266)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (267)..(291)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (292)..(299)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (300)..(324)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (325)..(331)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (332)..(362)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (363)..(371)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (372)..(382)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (383)..(402)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (403)..(428)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (429)..(434)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (435)..(454)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (455)..(467)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (468)..(490)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (491)..(499)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (500)..(509)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (510)..(510)
<223>  Xaa is a stop codon

<400>  441

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Met 
                245                 250                 255     


Asn Ser Glu Leu Ser Val Leu Ala Asn Ser Glu Val Gln Leu Val Gln 
            260                 265                 270         


Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys 
        275                 280                 285             


Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg 
    290                 295                 300                 


Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Asn Ile Asp Pro Tyr 
305                 310                 315                 320 


Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys Gly Gln Val Thr Ile 
                325                 330                 335     


Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu 
            340                 345                 350         


Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ser Val Gly Pro 
        355                 360                 365             


Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
                405                 410                 415     


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr 
            420                 425                 430         


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        435                 440                 445             


Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe 
    450                 455                 460                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
465                 470                 475                 480 


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn 
                485                 490                 495     


Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Xaa 
            500                 505                 510 


<210>  442
<211>  1557
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0077 nucleotide sequence - full length 
       sequence

<400>  442
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct      780

tccctgaata caagaactca gaaagcacgt cattgtccga attctgaggt gcagctggtg      840

cagtctggag cagaggtgaa aaagcccgga gagtctctga agatttcctg taagggctcc      900

ggttactcat tcactggcta caatatgaac tgggtgcgcc agatgcccgg gaaaggcctt      960

gagtggatgg gcaatattga tccttattat ggtggtacta cctacaaccg gaagttcaag     1020

ggccaggtca ctatctccgc cgacaagtcc atcagcaccg cctacctgca atggagcagc     1080

ctgaaggcct cggacaccgc catgtattac tgtgcacgct cagtcggccc tttcgactcc     1140

tggggccagg gcaccctggt cactgtctcc tctgggggtg gaggctctgg tggcggtgga     1200

tccggtggcg gcggatctgg cgggggtggc tctgaaattg tgttgacaca gtctccagcc     1260

accctgtctt tgtctccagg cgaaagagcc accctctcct gccgagcaag tgaaaatgtt     1320

tacagctact tagcctggta ccaacagaaa cctggccagg ctcctaggct cctcatctat     1380

tttgcaaaaa ccttagcaga aggtattcca gccaggttca gtggcagtgg ctccgggaca     1440

gacttcactc tcaccatcag cagcctagag cctgaagatt ttgcagttta ttactgtcaa     1500

catcattccg ataatccgtg gacattcggc caagggacca aggtggaaat caaatga        1557


<210>  443
<211>  519
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0077 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(275)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (276)..(300)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (301)..(308)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (309)..(333)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (334)..(340)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (341)..(371)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (372)..(380)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (381)..(391)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (392)..(411)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (412)..(437)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (438)..(443)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (444)..(463)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (464)..(476)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (477)..(499)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (500)..(508)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (509)..(518)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (519)..(519)
<223>  Xaa is a stop codon

<400>  443

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg 
                245                 250                 255     


His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg His Cys 
            260                 265                 270         


Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        275                 280                 285             


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
    290                 295                 300                 


Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn 
                325                 330                 335     


Arg Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
                405                 410                 415     


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
            420                 425                 430         


Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp Tyr Gln 
        435                 440                 445             


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala Lys Thr 
    450                 455                 460                 


Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
465                 470                 475                 480 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
                485                 490                 495     


Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly Gln Gly 
            500                 505                 510         


Thr Lys Val Glu Ile Lys Xaa 
        515                 


<210>  444
<211>  1572
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0094 nucleotide sequence - full length 
       sequence

<400>  444
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct      780

tccctgaata caagaactca gaaagcacgt cattctccga attctgaggt gcagctggtg      840

cagtctggag cagaggtgaa aaagcccgga gagtctctga agatttcctg taagggctcc      900

ggttactcat tcactggcta caatatgaac tgggtgcgcc agatgcccgg gaaaggcctt      960

gagtggatgg gcaatattga tccttattat ggtggtacta cctacaaccg gaagttcaag     1020

ggccaggtca ctatctccgc cgacaagtcc atcagcaccg cctacctgca atggagcagc     1080

ctgaaggcct cggacaccgc catgtattac tgtgcacgct cagtcggccc tttcgactcc     1140

tggggccagg gcaccctggt cactgtctcc tctgggggtg gaggctctgg tggcggtggc     1200

tctggcggag gtggatccgg tggcggcgga tctggcgggg gtggctctga aattgtgttg     1260

acacagtctc cagccaccct gtctttgtct ccaggcgaaa gagccaccct ctcctgccga     1320

gcaagtgaaa atgtttacag ctacttagcc tggtaccaac agaaacctgg ccaggctcct     1380

aggctcctca tctattttgc aaaaacctta gcagaaggta ttccagccag gttcagtggc     1440

agtggctccg ggacagactt cactctcacc atcagcagcc tagagcctga agattttgca     1500

gtttattact gtcaacatca ttccgataat ccgtggacat tcggccaagg gaccaaggtg     1560

gaaatcaaat ga                                                         1572


<210>  445
<211>  524
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0094 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(275)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (276)..(300)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (301)..(308)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (309)..(333)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (334)..(340)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (341)..(371)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (372)..(380)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (381)..(391)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (392)..(416)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (417)..(442)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (442)..(448)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (449)..(468)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (469)..(481)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (482)..(504)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (505)..(513)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (514)..(523)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (524)..(524)
<223>  Xaa is a stop codon

<400>  445

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg 
                245                 250                 255     


His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg His Ser 
            260                 265                 270         


Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        275                 280                 285             


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
    290                 295                 300                 


Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn 
                325                 330                 335     


Arg Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
            420                 425                 430         


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr 
        435                 440                 445             


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
    450                 455                 460                 


Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly 
465                 470                 475                 480 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
                485                 490                 495     


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp 
            500                 505                 510         


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Xaa 
        515                 520                 


<210>  446
<211>  1527
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0095 nucleotide sequence - full length 
       sequence

<400>  446
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct      780

tccctgaata caagaactca gaaagcacgt cattctccga attctgaggt gcagctggtg      840

cagtctggag cagaggtgaa aaagcccgga gagtctctga agatttcctg taagggctcc      900

ggttactcat tcactggcta caatatgaac tgggtgcgcc agatgcccgg gaaaggcctt      960

gagtggatgg gcaatattga tccttattat ggtggtacta cctacaaccg gaagttcaag     1020

ggccaggtca ctatctccgc cgacaagtcc atcagcaccg cctacctgca atggagcagc     1080

ctgaaggcct cggacaccgc catgtattac tgtgcacgct cagtcggccc tttcgactcc     1140

tggggccagg gcaccctggt cactgtctcc tctgggggtg gaggctctgg tggcggtgga     1200

tccgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc     1260

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa     1320

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca     1380

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag     1440

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc     1500

caagggacca aggtggaaat caaatga                                         1527


<210>  447
<211>  509
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0095 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(275)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (276)..(300)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (301)..(308)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (309)..(333)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (334)..(340)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (341)..(371)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (372)..(380)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (381)..(391)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (392)..(401)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (402)..(427)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (428)..(433)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (434)..(453)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (454)..(466)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (467)..(489)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (490)..(498)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (499)..(508)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (509)..(509)
<223>  Xaa is a stop codon

<400>  447

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg 
                245                 250                 255     


His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg His Ser 
            260                 265                 270         


Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        275                 280                 285             


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
    290                 295                 300                 


Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn 
                325                 330                 335     


Arg Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
                405                 410                 415     


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser 
            420                 425                 430         


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        435                 440                 445             


Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser 
    450                 455                 460                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
465                 470                 475                 480 


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro 
                485                 490                 495     


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Xaa 
            500                 505                 


<210>  448
<211>  1542
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0096 nucleotide sequence - full length 
       sequence

<400>  448
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct      780

tccctgaata caagaactca gaaagcacgt cattctccga attctgaggt gcagctggtg      840

cagtctggag cagaggtgaa aaagcccgga gagtctctga agatttcctg taagggctcc      900

ggttactcat tcactggcta caatatgaac tgggtgcgcc agatgcccgg gaaaggcctt      960

gagtggatgg gcaatattga tccttattat ggtggtacta cctacaaccg gaagttcaag     1020

ggccaggtca ctatctccgc cgacaagtcc atcagcaccg cctacctgca atggagcagc     1080

ctgaaggcct cggacaccgc catgtattac tgtgcacgct cagtcggccc tttcgactcc     1140

tggggccagg gcaccctggt cactgtctcc tctgggggtg gaggctctgg tggcggtggc     1200

tctggcggag gtggatccga aattgtgttg acacagtctc cagccaccct gtctttgtct     1260

ccaggcgaaa gagccaccct ctcctgccga gcaagtgaaa atgtttacag ctacttagcc     1320

tggtaccaac agaaacctgg ccaggctcct aggctcctca tctattttgc aaaaacctta     1380

gcagaaggta ttccagccag gttcagtggc agtggctccg ggacagactt cactctcacc     1440

atcagcagcc tagagcctga agattttgca gtttattact gtcaacatca ttccgataat     1500

ccgtggacat tcggccaagg gaccaaggtg gaaatcaaat ga                        1542


<210>  449
<211>  519
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0096 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(275)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (276)..(300)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (301)..(308)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (309)..(333)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (334)..(340)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (341)..(371)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (372)..(380)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (381)..(391)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (392)..(411)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (412)..(437)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (438)..(443)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (444)..(463)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (464)..(476)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (477)..(499)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (500)..(508)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (509)..(518)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (519)..(519)
<223>  Xaa is a stop codon

<400>  449

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg 
                245                 250                 255     


His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg His Ser 
            260                 265                 270         


Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        275                 280                 285             


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
    290                 295                 300                 


Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn 
                325                 330                 335     


Arg Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
                405                 410                 415     


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
            420                 425                 430         


Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp Tyr Gln 
        435                 440                 445             


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala Lys Thr 
    450                 455                 460                 


Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
465                 470                 475                 480 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
                485                 490                 495     


Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly Gln Gly 
            500                 505                 510         


Thr Lys Val Glu Ile Lys Xaa 
        515                 


<210>  450
<211>  1557
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0097 nucleotide sequence - full length 
       sequence

<400>  450
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct      780

tccctgaata caagaactca gaaagcacgt cattctccga attctgaggt gcagctggtg      840

cagtctggag cagaggtgaa aaagcccgga gagtctctga agatttcctg taagggctcc      900

ggttactcat tcactggcta caatatgaac tgggtgcgcc agatgcccgg gaaaggcctt      960

gagtggatgg gcaatattga tccttattat ggtggtacta cctacaaccg gaagttcaag     1020

ggccaggtca ctatctccgc cgacaagtcc atcagcaccg cctacctgca atggagcagc     1080

ctgaaggcct cggacaccgc catgtattac tgtgcacgct cagtcggccc tttcgactcc     1140

tggggccagg gcaccctggt cactgtctcc tctgggggtg gaggctctgg tggcggtgga     1200

tccggtggcg gcggatctgg cgggggtggc tctgaaattg tgttgacaca gtctccagcc     1260

accctgtctt tgtctccagg cgaaagagcc accctctcct gccgagcaag tgaaaatgtt     1320

tacagctact tagcctggta ccaacagaaa cctggccagg ctcctaggct cctcatctat     1380

tttgcaaaaa ccttagcaga aggtattcca gccaggttca gtggcagtgg ctccgggaca     1440

gacttcactc tcaccatcag cagcctagag cctgaagatt ttgcagttta ttactgtcaa     1500

catcattccg ataatccgtg gacattcggc caagggacca aggtggaaat caaatga        1557


<210>  451
<211>  519
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0097 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(275)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (276)..(300)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (301)..(308)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (309)..(333)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (334)..(340)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (341)..(371)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (372)..(380)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (381)..(391)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (392)..(411)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (412)..(437)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (438)..(443)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (444)..(463)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (464)..(476)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (477)..(499)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (500)..(508)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (509)..(518)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (519)..(519)
<223>  Xaa is a stop codon

<400>  451

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg 
                245                 250                 255     


His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg His Ser 
            260                 265                 270         


Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        275                 280                 285             


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
    290                 295                 300                 


Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn 
                325                 330                 335     


Arg Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
                405                 410                 415     


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
            420                 425                 430         


Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp Tyr Gln 
        435                 440                 445             


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala Lys Thr 
    450                 455                 460                 


Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
465                 470                 475                 480 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
                485                 490                 495     


Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly Gln Gly 
            500                 505                 510         


Thr Lys Val Glu Ile Lys Xaa 
        515                 


<210>  452
<211>  1557
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0050 nucleotide sequence - full length 
       sequence

<400>  452
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gttcctcgag cgagcccaaa tcttctgaca aaactcacac atgcccaccg      120

tgcccagcac ctgaactcct gggtggaccg tcagtcttcc tcttcccccc aaaacccaag      180

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      240

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      300

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc      360

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      420

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg      480

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg      540

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag      600

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc      660

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg      720

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggttctcca      780

ccttctccga attctcaggt gcagctgaag gagtcagggc ctggcagcgt ggcgccctca      840

cagagcctgt ccatcacatg caccgtctca gggttctcat taaccggcta tggtgtaaac      900

tgggttcgcc agcctccagg aaagggtctg gagtggctgg gaatgatatg gggtgatgga      960

agcacagact ataattcagc tctcaaatcc agactatcga tcaccaagga caactccaag     1020

agccaagttt tcttaaaaat gaacagtctg caaactgatg acacagccag atactactgt     1080

gctcgagatg gttatagtaa ctttcattac tatgttatgg actactgggg tcaaggaacc     1140

tcagtcaccg tctcctctgg gggtggaggc tctggtggcg gtggatccgg cggaggtggg     1200

tcgggtggcg gcggatctga cattgtgctc acccaatctc cagcttcttt ggctgtgtct     1260

ctaggtcaga gagccaccat ctcctgcaga gccagtgaaa gtgttgaata ttatgtcaca     1320

agtttaatgc agtggtacca acagaaacca ggacagccac ccaagctcct catctctgct     1380

gctagcaacg tagaatctgg ggtccctgcc aggtttagtg gcagtgggtc tgggacagac     1440

tttagcctca acatccatcc tgtggaggag gatgatattg caatgtattt ctgtcagcaa     1500

agtaggaagg ttccatggac gttcggtgga ggcaccaagc tggaaatcaa acgttaa        1557


<210>  453
<211>  515
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0050 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(261)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (262)..(286)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (287)..(294)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (295)..(311)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (312)..(318)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (319)..(356)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (357)..(371)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (372)..(382)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (383)..(402)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (403)..(428)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (429)..(438)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (439)..(455)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (456)..(458)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (459)..(494)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (495)..(503)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (504)..(513)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (515)..(515)
<223>  Xaa is a stop codon

<400>  453

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Pro 
                245                 250                 255     


Pro Ser Pro Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Ser 
            260                 265                 270         


Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe 
        275                 280                 285             


Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys 
    290                 295                 300                 


Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr 
305                 310                 315                 320 


Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys 
                325                 330                 335     


Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
            340                 345                 350         


Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val 
        355                 360                 365             


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 
                405                 410                 415     


Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu 
            420                 425                 430         


Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln 
        435                 440                 445             


Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val 
    450                 455                 460                 


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn 
465                 470                 475                 480 


Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln 
                485                 490                 495     


Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            500                 505                 510         


Lys Arg Xaa 
        515 


<210>  454
<211>  1581
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0051 nucleotide sequence - full length 
       sequence

<400>  454
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gttcctcgag cgagcccaaa tcttctgaca aaactcacac atgcccaccg      120

tgcccagcac ctgaactcct gggtggaccg tcagtcttcc tcttcccccc aaaacccaag      180

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      240

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      300

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc      360

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      420

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg      480

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg      540

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag      600

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc      660

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg      720

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtctgtct      780

gtgaaagctg acttcctcac tccatccatc gggaattctc aggtgcagct gaaggagtca      840

gggcctggca gcgtggcgcc ctcacagagc ctgtccatca catgcaccgt ctcagggttc      900

tcattaaccg gctatggtgt aaactgggtt cgccagcctc caggaaaggg tctggagtgg      960

ctgggaatga tatggggtga tggaagcaca gactataatt cagctctcaa atccagacta     1020

tcgatcacca aggacaactc caagagccaa gttttcttaa aaatgaacag tctgcaaact     1080

gatgacacag ccagatacta ctgtgctcga gatggttata gtaactttca ttactatgtt     1140

atggactact ggggtcaagg aacctcagtc accgtctcct ctgggggtgg aggctctggt     1200

ggcggtggat ccggcggagg tgggtcgggt ggcggcggat ctgacattgt gctcacccaa     1260

tctccagctt ctttggctgt gtctctaggt cagagagcca ccatctcctg cagagccagt     1320

gaaagtgttg aatattatgt cacaagttta atgcagtggt accaacagaa accaggacag     1380

ccacccaagc tcctcatctc tgctgctagc aacgtagaat ctggggtccc tgccaggttt     1440

agtggcagtg ggtctgggac agactttagc ctcaacatcc atcctgtgga ggaggatgat     1500

attgcaatgt atttctgtca gcaaagtagg aaggttccat ggacgttcgg tggaggcacc     1560

aagctggaaa tcaaacgtta a                                               1581


<210>  455
<211>  523
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0051 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(269)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (270)..(294)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (295)..(302)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (303)..(319)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (320)..(326)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (327)..(364)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (365)..(379)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (380)..(390)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (391)..(410)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (411)..(436)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (437)..(446)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (447)..(463)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (464)..(466)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (467)..(502)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (503)..(511)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (512)..(521)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (523)..(523)
<223>  Xaa is a stop codon

<400>  455

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Leu Ser 
                245                 250                 255     


Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser Gln Val Gln 
            260                 265                 270         


Leu Lys Glu Ser Gly Pro Gly Ser Val Ala Pro Ser Gln Ser Leu Ser 
        275                 280                 285             


Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn 
    290                 295                 300                 


Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile 
305                 310                 315                 320 


Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
                325                 330                 335     


Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
            340                 345                 350         


Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly 
        355                 360                 365             


Tyr Ser Asn Phe His Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
                405                 410                 415     


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
            420                 425                 430         


Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala 
    450                 455                 460                 


Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp 
                485                 490                 495     


Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe 
            500                 505                 510         


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Xaa 
        515                 520             


<210>  456
<211>  1572
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0052 nucleotide sequence - full length 
       sequence

<400>  456
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gttcctcgag cgagcccaaa tcttctgaca aaactcacac atgcccaccg      120

tgcccagcac ctgaactcct gggtggaccg tcagtcttcc tcttcccccc aaaacccaag      180

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      240

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      300

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc      360

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      420

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg      480

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg      540

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag      600

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc      660

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg      720

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtcagatg      780

aactccgagt tgagcgtgct cgcgaattct caggtgcagc tgaaggagtc agggcctggc      840

agcgtggcgc cctcacagag cctgtccatc acatgcaccg tctcagggtt ctcattaacc      900

ggctatggtg taaactgggt tcgccagcct ccaggaaagg gtctggagtg gctgggaatg      960

atatggggtg atggaagcac agactataat tcagctctca aatccagact atcgatcacc     1020

aaggacaact ccaagagcca agttttctta aaaatgaaca gtctgcaaac tgatgacaca     1080

gccagatact actgtgctcg agatggttat agtaactttc attactatgt tatggactac     1140

tggggtcaag gaacctcagt caccgtctcc tctgggggtg gaggctctgg tggcggtgga     1200

tccggcggag gtgggtcggg tggcggcgga tctgacattg tgctcaccca atctccagct     1260

tctttggctg tgtctctagg tcagagagcc accatctcct gcagagccag tgaaagtgtt     1320

gaatattatg tcacaagttt aatgcagtgg taccaacaga aaccaggaca gccacccaag     1380

ctcctcatct ctgctgctag caacgtagaa tctggggtcc ctgccaggtt tagtggcagt     1440

gggtctggga cagactttag cctcaacatc catcctgtgg aggaggatga tattgcaatg     1500

tatttctgtc agcaaagtag gaaggttcca tggacgttcg gtggaggcac caagctggaa     1560

atcaaacgtt aa                                                         1572


<210>  457
<211>  520
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0052 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(266)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (267)..(291)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (292)..(299)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (300)..(316)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (317)..(323)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (324)..(361)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (362)..(376)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (377)..(387)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (388)..(407)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (408)..(433)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (434)..(443)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (444)..(460)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (461)..(463)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (464)..(499)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (500)..(508)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (509)..(518)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (520)..(520)
<223>  Xaa is a stop codon

<400>  457

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Met 
                245                 250                 255     


Asn Ser Glu Leu Ser Val Leu Ala Asn Ser Gln Val Gln Leu Lys Glu 
            260                 265                 270         


Ser Gly Pro Gly Ser Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys 
        275                 280                 285             


Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg 
    290                 295                 300                 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp 
305                 310                 315                 320 


Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr 
                325                 330                 335     


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
            340                 345                 350         


Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn 
        355                 360                 365             


Phe His Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
    370                 375                 380                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
                405                 410                 415     


Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
            420                 425                 430         


Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln 
        435                 440                 445             


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn 
    450                 455                 460                 


Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
465                 470                 475                 480 


Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met 
                485                 490                 495     


Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly 
            500                 505                 510         


Thr Lys Leu Glu Ile Lys Arg Xaa 
        515                 520 


<210>  458
<211>  1599
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0053 nucleotide sequence - full length 
       sequence

<400>  458
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gttcctcgag cgagcccaaa tcttctgaca aaactcacac atgcccaccg      120

tgcccagcac ctgaactcct gggtggaccg tcagtcttcc tcttcccccc aaaacccaag      180

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      240

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      300

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc      360

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      420

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg      480

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg      540

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag      600

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc      660

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg      720

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtcagagg      780

cacaacaatt cttccctgaa tacaagaact cagaaagcac gtcattgtcc gaattctcag      840

gtgcagctga aggagtcagg gcctggcagc gtggcgccct cacagagcct gtccatcaca      900

tgcaccgtct cagggttctc attaaccggc tatggtgtaa actgggttcg ccagcctcca      960

ggaaagggtc tggagtggct gggaatgata tggggtgatg gaagcacaga ctataattca     1020

gctctcaaat ccagactatc gatcaccaag gacaactcca agagccaagt tttcttaaaa     1080

atgaacagtc tgcaaactga tgacacagcc agatactact gtgctcgaga tggttatagt     1140

aactttcatt actatgttat ggactactgg ggtcaaggaa cctcagtcac cgtctcctct     1200

gggggtggag gctctggtgg cggtggatcc ggcggaggtg ggtcgggtgg cggcggatct     1260

gacattgtgc tcacccaatc tccagcttct ttggctgtgt ctctaggtca gagagccacc     1320

atctcctgca gagccagtga aagtgttgaa tattatgtca caagtttaat gcagtggtac     1380

caacagaaac caggacagcc acccaagctc ctcatctctg ctgctagcaa cgtagaatct     1440

ggggtccctg ccaggtttag tggcagtggg tctgggacag actttagcct caacatccat     1500

cctgtggagg aggatgatat tgcaatgtat ttctgtcagc aaagtaggaa ggttccatgg     1560

acgttcggtg gaggcaccaa gctggaaatc aaacgttaa                            1599


<210>  459
<211>  529
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0053 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(275)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (276)..(300)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (301)..(308)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (309)..(325)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (326)..(332)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (333)..(370)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (371)..(385)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (386)..(396)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (397)..(416)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (417)..(442)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (443)..(452)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (453)..(469)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (470)..(472)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (473)..(508)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (509)..(517)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (518)..(527)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (529)..(529)
<223>  Xaa is a stop codon

<400>  459

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg 
                245                 250                 255     


His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg His Cys 
            260                 265                 270         


Pro Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Ser Val Ala 
        275                 280                 285             


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
    290                 295                 300                 


Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser 
                325                 330                 335     


Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln 
            340                 345                 350         


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr 
        355                 360                 365             


Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met Asp 
    370                 375                 380                 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
            420                 425                 430         


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
        435                 440                 445             


Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
    450                 455                 460                 


Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
465                 470                 475                 480 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
                485                 490                 495     


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg 
            500                 505                 510         


Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        515                 520                 525             


Xaa 
    


<210>  460
<211>  1599
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0083 nucleotide sequence - full length 
       sequence

<400>  460
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gttcctcgag cgagcccaaa tcttctgaca aaactcacac atgcccaccg      120

tgcccagcac ctgaactcct gggtggaccg tcagtcttcc tcttcccccc aaaacccaag      180

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      240

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      300

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc      360

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      420

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg      480

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg      540

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag      600

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc      660

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg      720

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtcagagg      780

cacaacaatt cttccctgaa tacaagaact cagaaagcac gtcattctcc gaattctcag      840

gtgcagctga aggagtcagg gcctggcagc gtggcgccct cacagagcct gtccatcaca      900

tgcaccgtct cagggttctc attaaccggc tatggtgtaa actgggttcg ccagcctcca      960

ggaaagggtc tggagtggct gggaatgata tggggtgatg gaagcacaga ctataattca     1020

gctctcaaat ccagactatc gatcaccaag gacaactcca agagccaagt tttcttaaaa     1080

atgaacagtc tgcaaactga tgacacagcc agatactact gtgctcgaga tggttatagt     1140

aactttcatt actatgttat ggactactgg ggtcaaggaa cctcagtcac cgtctcctct     1200

gggggtggag gctctggtgg cggtggatcc ggcggaggtg ggtcgggtgg cggcggatct     1260

gacattgtgc tcacccaatc tccagcttct ttggctgtgt ctctaggtca gagagccacc     1320

atctcctgca gagccagtga aagtgttgaa tattatgtca caagtttaat gcagtggtac     1380

caacagaaac caggacagcc acccaagctc ctcatctctg ctgctagcaa cgtagaatct     1440

ggggtccctg ccaggtttag tggcagtggg tctgggacag actttagcct caacatccat     1500

cctgtggagg aggatgatat tgcaatgtat ttctgtcagc aaagtaggaa ggttccatgg     1560

acgttcggtg gaggcaccaa gctggaaatc aaacgttaa                            1599


<210>  461
<211>  529
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0083 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(275)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (276)..(300)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (301)..(308)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (309)..(325)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (326)..(332)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (333)..(370)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (371)..(385)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (386)..(396)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (397)..(416)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (417)..(442)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (443)..(452)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (453)..(469)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (470)..(472)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (473)..(508)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (509)..(517)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (518)..(527)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (529)..(529)
<223>  Xaa is a stop codon

<400>  461

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg 
                245                 250                 255     


His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg His Ser 
            260                 265                 270         


Pro Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Ser Val Ala 
        275                 280                 285             


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
    290                 295                 300                 


Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser 
                325                 330                 335     


Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln 
            340                 345                 350         


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr 
        355                 360                 365             


Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met Asp 
    370                 375                 380                 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
            420                 425                 430         


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
        435                 440                 445             


Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
    450                 455                 460                 


Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
465                 470                 475                 480 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
                485                 490                 495     


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg 
            500                 505                 510         


Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        515                 520                 525             


Xaa 
    


<210>  462
<211>  318
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide F3.3 Vk nt seq

<400>  462
gaaattgagc tcacccagtc tccagcaatc atgtctgtat ttccagggga gaaggtcacc       60

atgacctgca gtgccagctc aattgtacgt tatatgtatt ggttccagca gaagccagga      120

tcctccccca gactcctgat ttatgacaca tccagcctgt cttccggagt ccctgttcgc      180

ttcagtggca gtgggtctgg gacctcctat tctctcacaa tcagccgaat ggaggctgta      240

gatgctgcca cttatttctg ccagcagtgg agtagttacc cactcacgtt cggtggtggg      300

accaagctgg aaataaaa                                                    318


<210>  463
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide F3.3 Vk aa seq

<400>  463

Glu Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Val Phe Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ile Val Arg Tyr Met 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Ser Leu Ser Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Val 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Phe Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  464
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide F3.3 Vh nt seq

<400>  464
gaggtgcagc tggaggaatc tggaggaggc ttggtgcaac ctggaggatc catgaaactc       60

tcctgtgttg cctctggatt cactttcagt aattcctgga tgaactgggt ccgccagtct      120

ccagaaaagg ggcttgaatg ggttgctgaa attagattga aatctaataa ttatgcaaca      180

cgttatgcgg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaagtagt      240

gtctacctgc aaatgaacaa cttaagatct gaagacactg ccatttatta ctgtaccccc      300

ttatcttact cctttgacta ctggggccaa gggaccacgg tcaccgtctc gaca            354


<210>  465
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide F3.3 Vh aa seq

<400>  465

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr Arg Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ser Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Pro Leu Ser Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Thr 
        115             


<210>  466
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide IGHV3-73

<400>  466

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ala Asn Ser Tyr Ala Thr Ala Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg 
            100 


<210>  467
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide F3VHG4S1Bamf

<400>  467
ggtggatccg gtggcggcgg cggatctgag gtgcagctgg aggaatctgg a                51


<210>  468
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide F3VHf1

<400>  468
ggtgcagctg gaggaatctg gaggaggctt ggtgcaacct ggaggatcca                  50


<210>  469
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide F3VHf2

<400>  469
ttggtgcaac ctggaggatc catgaaactc tcctgtgttg cctctggatt c                51


<210>  470
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide F3VHf3

<400>  470
tctcctgtgt tgcctctgga ttcactttca gtaattcctg gatgaactgg gt               52


<210>  471
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide F3VHf4

<400>  471
gtaattcctg gatgaactgg gtccgccagt ctccagaaaa ggggcttgaa tgg              53


<210>  472
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide F3VHf5

<400>  472
ctccagaaaa ggggcttgaa tgggttgctg aaattagatt gaaatctaat aa               52


<210>  473
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide F3VHf6

<400>  473
gaaattagat tgaaatctaa taattatgca acacgttatg cggagtctgt                  50


<210>  474
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide F3VHr6

<400>  474
tctcttgaga tggtgaacct ccctttcaca gactccgcat aacgtgttgc                  50


<210>  475
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide F3VHr7

<400>  475
ttgcaggtag acactacttt tggaatcatc tcttgagatg gtgaacctcc                  50


<210>  476
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide F3VHr8

<400>  476
agtgtcttca gatcttaagt tgttcatttg caggtagaca ctacttttgg                  50


<210>  477
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide F3VHr9

<400>  477
agataagggg gtacagtaat aaatggcagt gtcttcagat cttaagttgt                  50


<210>  478
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide F3VHr10

<400>  478
tcccttggcc ccagtagtca aaggagtaag ataagggggt acagtaataa                  50


<210>  479
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide F3VHr11Bcl

<400>  479
gctcctgatc agtcgagacg gtgaccgtgg tcccttggcc ccagtagtca aag              53


<210>  480
<211>  1557
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0029 (13bp - 1569bp, direct)

<400>  480
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaggggtg tccaccttgt      780

ccgaattctg aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct      840

ctgaagattt cctgtaaggg atctggatac agctttacca gctactggat gaactgggtg      900

cgccagatgc ccgggaaagg cctggagtgg atggggcaga tttggcctgg agatggtgat      960

actaactaca atggaaagtt caagggccag gtcactatct cagccgacaa gtccatcagc     1020

accgcctacc tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca     1080

cgcagagaga ctacgacggt aggccgttat tactatgcta tggactactg gggtcagggc     1140

accctggtca ctgtctcctc tggtggcggt agctcgggcg gtggtgggtc gggtggcggc     1200

ggatcaggag gaggcgggag tgacattgtg ctgacccaat ctccagcttc tttggctgtg     1260

tctctagggc agagggccac catctcctgc aaggccagcc aaagtgttga ttatgatggt     1320

gatagttatt tgaactggta ccaacagatt ccaggacagc cacccaaact cctcatctat     1380

gatgcatcca atctagtttc tgggatccca cccaggttta gtggcagtgg gtctgggaca     1440

gacttcaccc tcaacatcca tcctgtggag aaggtggatg ctgcaaccta tcactgtcag     1500

caaagtactg aggatccgtg gacgttcggt ggaggcacca agctggaaat caaatga        1557


<210>  481
<211>  519
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0029_prot (1aa - 519aa)


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (256)..(263)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (264)..(293)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (294)..(298)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (299)..(312)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (313)..(329)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (330)..(361)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (362)..(376)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (377)..(387)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (388)..(407)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (431)..(430)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (431)..(445)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (446)..(460)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (461)..(467)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (468)..(499)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (500)..(508)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (509)..(518)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (519)..(519)
<223>  Xaa is a stop codon

<400>  481

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
            260                 265                 270         


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
        275                 280                 285             


Gly Tyr Ser Phe Thr Ser Tyr Trp Met Asn Trp Val Arg Gln Met Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Met Gly Gln Ile Trp Pro Gly Asp Gly Asp 
305                 310                 315                 320 


Thr Asn Tyr Asn Gly Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp 
                325                 330                 335     


Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
            340                 345                 350         


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Glu Thr Thr Thr Val Gly 
        355                 360                 365             


Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
    370                 375                 380                 


Val Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
                405                 410                 415     


Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala 
            420                 425                 430         


Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Leu Asn Trp Tyr Gln 
        435                 440                 445             


Gln Ile Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn 
    450                 455                 460                 


Leu Val Ser Gly Ile Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr 
465                 470                 475                 480 


Asp Phe Thr Leu Asn Ile His Pro Val Glu Lys Val Asp Ala Ala Thr 
                485                 490                 495     


Tyr His Cys Gln Gln Ser Thr Glu Asp Pro Trp Thr Phe Gly Gly Gly 
            500                 505                 510         


Thr Lys Leu Glu Ile Lys Xaa 
        515                 


<210>  482
<211>  1545
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0030 (13bp - 1557bp, direct)

<400>  482
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaggggtg tccaccttgt      780

ccgaattctc aggttcagct gcagcagtct ggggctgagc tggtgaggcc tgggtcctca      840

gtgaagattt cctgcaaggc ttctggctat gcattcagta gctactggat gaactgggtg      900

aagcagaggc ctggacaggg tcttgagtgg attggacaga tttggcctgg agatggtgat      960

actaactaca atggaaagtt caagggtaaa gccactctga ctgcagacga atcctccagc     1020

acagcctaca tgcaactcag cagcctagca tctgaggact ctgcggtcta tttctgtgca     1080

agacgggaga ctacgacggt aggccgttat tactatgcta tggactactg gggtcaagga     1140

acctcagtca ccgtctcctc tggtggcggt ggctcgggcg gtggtgggtc gggtggcggc     1200

ggagctagcg acattgtgct gacccaatct ccagcttctt tggctgtgtc tctagggcag     1260

agggccacca tctcctgcaa ggccagccaa agtgttgatt atgatggtga tagttatttg     1320

aactggtacc aacagattcc aggacagcca cccaaactcc tcatctatga tgcatccaat     1380

ctagtttctg ggatcccacc caggtttagt ggcagtgggt ctgggacaga cttcaccctc     1440

aacatccatc ctgtggagaa ggtggatgct gcaacctatc actgtcagca aagtactgag     1500

gatccgtgga cgttcggtgg aggcaccaag ctggaaatca aatga                     1545


<210>  483
<211>  515
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0030_prot (1aa - 515aa)


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (256)..(263)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (264)..(293)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (294)..(298)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (299)..(312)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (313)..(329)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (330)..(361)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (362)..(376)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (377)..(387)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (388)..(403)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (404)..(426)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (427)..(441)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (442)..(456)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (457)..(463)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (464)..(495)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (496)..(504)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (505)..(514)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (515)..(515)
<223>  Xaa is a stop codon

<400>  483

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Gln Val Gln Leu Gln Gln Ser Gly Ala 
            260                 265                 270         


Glu Leu Val Arg Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser 
        275                 280                 285             


Gly Tyr Ala Phe Ser Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro 
    290                 295                 300                 


Gly Gln Gly Leu Glu Trp Ile Gly Gln Ile Trp Pro Gly Asp Gly Asp 
305                 310                 315                 320 


Thr Asn Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp 
                325                 330                 335     


Glu Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Ala Ser Glu 
            340                 345                 350         


Asp Ser Ala Val Tyr Phe Cys Ala Arg Arg Glu Thr Thr Thr Val Gly 
        355                 360                 365             


Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
    370                 375                 380                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ala Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
                405                 410                 415     


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val 
            420                 425                 430         


Asp Tyr Asp Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly 
        435                 440                 445             


Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly 
    450                 455                 460                 


Ile Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
465                 470                 475                 480 


Asn Ile His Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln 
                485                 490                 495     


Gln Ser Thr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
            500                 505                 510         


Ile Lys Xaa 
        515 


<210>  484
<211>  1551
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0031 (13bp - 1563bp, direct)

<400>  484
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaggggtg tccaccttgt      780

ccgaattctg aggtccagct ccagcagtct ggacctgagc tgataaagcc tggtgcttca      840

gtgaagatgt cctgcaaggc ttctggatac acattcacta gctatgttat gcactgggtg      900

aagcagaagc ctgggcaggg ccttgagtgg attggatata ttaatcctta caatgatggt      960

actaagtaca atgagaagtt caaaggcaag gccacactga cttcagacaa atcctccagc     1020

acagcctaca tggaactcag cagcctgacc tctgaggact ctgcggtcta ttactgtgca     1080

agagggactt attactacgg tagtagggta tttgactact ggggccaagg caccactctc     1140

acagtctcct cagggggtgg aggctctggt ggcggtggct ctggcggagg agggtccggt     1200

ggcggcggat ccgatattgt gatgactcag gctgcaccct ctatacctgt cactcctgga     1260

gagtcagtat ccatctcctg caggtctagt aagagtctcc tgaatagtaa tggcaacact     1320

tacttgtatt ggttcctgca gaggccaggc cagtctcctc agctcctgat atatcggatg     1380

tccaaccttg cctcaggagt cccagacagg ttcagtggca gtgggtcagg aactgctttc     1440

acactgagaa tcagtagagt ggaggctgag gatgtgggtg tttattactg tatgcaacat     1500

cttgaatatc cattcacatt cggtgctggg accaagctgg agctgaaatg a              1551


<210>  485
<211>  517
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0031_prot (1aa - 517aa)


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (256)..(263)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (264)..(293)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (294)..(298)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (299)..(312)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (313)..(329)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (330)..(361)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (362)..(373)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (374)..(384)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (385)..(404)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (405)..(427)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (428)..(443)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (444)..(458)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (459)..(465)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (466)..(497)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (498)..(506)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (507)..(516)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (517)..(517)
<223>  Xaa is a stop codon

<400>  485

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Pro 
            260                 265                 270         


Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser 
        275                 280                 285             


Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro 
    290                 295                 300                 


Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly 
305                 310                 315                 320 


Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp 
                325                 330                 335     


Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu 
            340                 345                 350         


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser 
        355                 360                 365             


Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro 
                405                 410                 415     


Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser 
            420                 425                 430         


Leu Leu Asn Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg 
        435                 440                 445             


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala 
    450                 455                 460                 


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe 
465                 470                 475                 480 


Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
                485                 490                 495     


Cys Met Gln His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys 
            500                 505                 510         


Leu Glu Leu Lys Xaa 
        515         


<210>  486
<211>  1530
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0028 nucleotide sequence - full length 
       sequence

<400>  486
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaggggtg tccaccttgt      780

ccgaattctg cggtccagct gcagcagtct ggacctgagt cggaaaagcc tggcgcttca      840

gtgaagattt cctgcaaggc ttctggttac tcattcactg gctacaatat gaactgggtg      900

aagcagaata atggaaagag ccttgagtgg attggaaata ttgatcctta ttatggtggt      960

actacctaca accggaagtt caagggcaag gccacattga ctgtagacaa atcctccggc     1020

acagcctaca tgcagctcaa gagtctgaca tctgaggact ctgcagtcta ttactgtgca     1080

agatcggtcg gccctatgga ctactggggt caaggaacct cagtcaccgt ctcttctggt     1140

ggcggtggct cgggcggtgg tgggtcgggt ggcggcggat caggaggagg cgggagtgct     1200

agcgacatcc agatgactca gtctccagcc tccctatctg catctgtggg agagactgtc     1260

accatcacat gtcgaacaag tgaaaatgtt tacagttatt tggcttggta tcagcagaaa     1320

cagggaaaat ctcctcagct cctggtctct tttgcaaaaa ccttagcaga aggtgtgcca     1380

tcaaggttca gtggcagtgg atcaggcaca cagttttctc tgaagatcag cagcctgcag     1440

cctgaagatt ctggaagtta tttctgtcaa catcattccg ataatccgtg gacgttcggt     1500

ggaggcaccg aactggagat caaaggttga                                      1530


<210>  487
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide W0028 amino acid sequence - full length 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(255)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (256)..(263)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (264)..(288)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (289)..(296)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (297)..(313)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (314)..(321)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (322)..(359)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (360)..(368)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (369)..(379)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (380)..(401)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (402)..(427)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (428)..(433)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (434)..(450)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (451)..(453)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (454)..(489)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (490)..(498)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (499)..(508)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (510)..(510)
<223>  Xaa is a stop codon

<400>  487

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Ala Val Gln Leu Gln Gln Ser Gly Pro 
            260                 265                 270         


Glu Ser Glu Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser 
        275                 280                 285             


Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Lys Gln Asn Asn 
    290                 295                 300                 


Gly Lys Ser Leu Glu Trp Ile Gly Asn Ile Asp Pro Tyr Tyr Gly Gly 
305                 310                 315                 320 


Thr Thr Tyr Asn Arg Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp 
                325                 330                 335     


Lys Ser Ser Gly Thr Ala Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu 
            340                 345                 350         


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Val Gly Pro Met Asp Tyr 
        355                 360                 365             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
385                 390                 395                 400 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val 
                405                 410                 415     


Gly Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Val Tyr Ser 
            420                 425                 430         


Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu 
        435                 440                 445             


Val Ser Phe Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser 
    450                 455                 460                 


Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Ser Ser Leu Gln 
465                 470                 475                 480 


Pro Glu Asp Ser Gly Ser Tyr Phe Cys Gln His His Ser Asp Asn Pro 
                485                 490                 495     


Trp Thr Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Gly Xaa 
            500                 505                 510 


<210>  488
<211>  1546
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0011 with H7

<400>  488
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gttcctcgag cgagcccaaa tcttctgaca aaactcacac atgcccaccg      120

tgcccagcac ctgaactcct gggtggaccg tcagtcttcc tcttcccccc aaaacccaag      180

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      240

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      300

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc      360

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      420

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg      480

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg      540

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag      600

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc      660

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg      720

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaagggg      780

tgtccacctt gtccgaattc tcaggtgcag ctggtgcagt ctggtgctga gagcaagaag      840

cctggggcct cagtgaaggt ttcctgcaag gccagcggat acaccttcac cagctacaat      900

atgcactggg tgcgacaggc gcctggacaa gggctagagt ggatgggagc tatctatcct      960

ggaaatggtg atacatccta caatcagaag ttcaagggca gggtcaccat gaccagagac     1020

acgtccacga gcacagtcta catggagctg agcagcctga gatctgagga cacggccgtg     1080

tattactgtg cccgaagcta ctatagtaac tcttactggt acttcgatct ctggggccgc     1140

ggcaccctgg tcactgtctc ctcggggggc ggtggatcgg gcggtggtgg atctggagga     1200

ggtgggtctg ctagcgaaat tgtgttgaca cagtctccag ccaccctgtc tttgtctcca     1260

ggtgaaagag ccaccctctc ctgcagggcc agttccagtg ttagctacat tgtttggtac     1320

caacagaaac ctggccaggc acctaggctc ctcatctatg ccccatccaa cctggcttct     1380

ggaataccag ccaggttcag tggcagtgga tccgggacag acttcactct caccatcagc     1440

agtcttgagc ctgaagattt tgcagtttat tactgtcagc agtggagttt taaccctccc     1500

acgttcggcc aagggaccaa ggtggaaatc aaagactgag tctaga                    1546


<210>  489
<211>  1547
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0035 nt

<400>  489
agcttgccgc catggaagca ccagcgcagc ttctcttcct cctgctactc tggctcccag       60

ataccaccgg ttcctcgagc gagcccaaat cttctgacaa aactcacaca tgcccaccgt      120

gcccagcacc tgaactcctg ggtggaccgt cagtcttcct cttcccccca aaacccaagg      180

acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac gtgagccacg      240

aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat aatgccaaga      300

caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc      360

tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc      420

cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa ccacaggtgt      480

acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg acctgcctgg      540

tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg cagccggaga      600

acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc ctctacagca      660

agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc tccgtgatgc      720

atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg ggtaaggggt      780

gtccaccttg tccgaattct gaaattgagc tcacccagtc tccagcaatc atgtctgtat      840

ttccagggga gaaggtcacc atgacctgca gtgccagctc aattgtacgt tatatgtatt      900

ggttccagca gaagccaggg tcctccccca gactcctgat ttatgacaca tccagcctgt      960

cttccggagt ccctgttcgc ttcagtggca gtgggtctgg gacctcctat tctctcacaa     1020

tcagccgaat ggaggctgta gatgctgcca cttatttctg ccagcagtgg agtagttacc     1080

cactcacgtt cggtggtggg accaagctgg aaataaaagg gggtggaggc tctggtggcg     1140

gtggctctgg cggaggtgga tccggtggcg gcggcggatc tgaggtgcag ctggaggaat     1200

ctggaggagg cttggtgcaa cctggagggt ccatgaaact ctcctgtgtt gcctctggat     1260

tcactttcag taattcctgg atgaactggg tccgccagtc tccagaaaag gggcttgaat     1320

gggttgctga aattagattg aaatctaata attacgcaac acgttatgcg gagtctgtga     1380

aagggaggtt caccatctca agagatgatt ccaaaagtag tgtctacctg caaatgaaca     1440

acttaagatc tgaagacact gccatttatt actgtacccc cttatcttac tcctttgact     1500

actggggcca agggaccacg gtcaccgtct cgacttgatt ttctaga                   1547


<210>  490
<211>  508
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide WO035 aa (W zero zero 35)


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(263)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (264)..(289)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (290)..(294)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (295)..(311)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (312)..(314)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (315)..(350)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (351)..(359)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (360)..(369)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (370)..(390)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (391)..(415)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (416)..(423)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (424)..(440)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (441)..(450)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (451)..(488)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (489)..(497)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (498)..(508)
<223>  Heavy region

<400>  490

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Cys Pro Pro Cys Pro Asn Ser Glu Ile Glu Leu Thr Gln Ser Pro Ala 
            260                 265                 270         


Ile Met Ser Val Phe Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
        275                 280                 285             


Ser Ser Ile Val Arg Tyr Met Tyr Trp Phe Gln Gln Lys Pro Gly Ser 
    290                 295                 300                 


Ser Pro Arg Leu Leu Ile Tyr Asp Thr Ser Ser Leu Ser Ser Gly Val 
305                 310                 315                 320 


Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
                325                 330                 335     


Ile Ser Arg Met Glu Ala Val Asp Ala Ala Thr Tyr Phe Cys Gln Gln 
            340                 345                 350         


Trp Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        355                 360                 365             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Glu Glu Ser Gly Gly Gly 
385                 390                 395                 400 


Leu Val Gln Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly 
                405                 410                 415     


Phe Thr Phe Ser Asn Ser Trp Met Asn Trp Val Arg Gln Ser Pro Glu 
            420                 425                 430         


Lys Gly Leu Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr 
        435                 440                 445             


Ala Thr Arg Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    450                 455                 460                 


Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg Ser 
465                 470                 475                 480 


Glu Asp Thr Ala Ile Tyr Tyr Cys Thr Pro Leu Ser Tyr Ser Phe Asp 
                485                 490                 495     


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Thr 
            500                 505             


<210>  491
<211>  1584
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0036 nt

<400>  491
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gttcctcgag cgagcccaaa tcttctgaca aaactcacac atgcccaccg      120

tgcccagcac ctgaactcct gggtggaccg tcagtcttcc tcttcccccc aaaacccaag      180

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      240

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      300

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc      360

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      420

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg      480

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg      540

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag      600

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc      660

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg      720

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtcagagg      780

cacaacaatt cttccctgaa tacaagaact cagaaagcac gtcattgtcc gaattctgaa      840

attgagctca cccagtctcc agcaatcatg tctgtatttc caggggagaa ggtcaccatg      900

acctgcagtg ccagctcaat tgtacgttat atgtattggt tccagcagaa gccagggtcc      960

tcccccagac tcctgattta tgacacatcc agcctgtctt ccggagtccc tgttcgcttc     1020

agtggcagtg ggtctgggac ctcctattct ctcacaatca gccgaatgga ggctgtagat     1080

gctgccactt atttctgcca gcagtggagt agttacccac tcacgttcgg tggtgggacc     1140

aagctggaaa taaaaggggg tggaggctct ggtggcggtg gctctggcgg aggtggatcc     1200

ggtggcggcg gcggatctga ggtgcagctg gaggaatctg gaggaggctt ggtgcaacct     1260

ggagggtcca tgaaactctc ctgtgttgcc tctggattca ctttcagtaa ttcctggatg     1320

aactgggtcc gccagtctcc agaaaagggg cttgaatggg ttgctgaaat tagattgaaa     1380

tctaataatt acgcaacacg ttatgcggag tctgtgaaag ggaggttcac catctcaaga     1440

gatgattcca aaagtagtgt ctacctgcaa atgaacaact taagatctga agacactgcc     1500

atttattact gtaccccctt atcttactcc tttgactact ggggccaagg gaccacggtc     1560

accgtctcga cttgattttc taga                                            1584


<210>  492
<211>  520
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0036 aa


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(275)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (276)..(301)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (302)..(306)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (307)..(323)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (324)..(326)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (327)..(362)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (363)..(371)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (372)..(381)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (382)..(402)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (403)..(427)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (428)..(435)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (436)..(452)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (453)..(462)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (463)..(500)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (501)..(509)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (510)..(520)
<223>  Heavy region

<400>  492

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg 
                245                 250                 255     


His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg His Cys 
            260                 265                 270         


Pro Asn Ser Glu Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Val 
        275                 280                 285             


Phe Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ile Val 
    290                 295                 300                 


Arg Tyr Met Tyr Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu 
305                 310                 315                 320 


Leu Ile Tyr Asp Thr Ser Ser Leu Ser Ser Gly Val Pro Val Arg Phe 
                325                 330                 335     


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met 
            340                 345                 350         


Glu Ala Val Asp Ala Ala Thr Tyr Phe Cys Gln Gln Trp Ser Ser Tyr 
        355                 360                 365             


Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro 
                405                 410                 415     


Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser 
            420                 425                 430         


Asn Ser Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu 
        435                 440                 445             


Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr Arg Tyr 
    450                 455                 460                 


Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
465                 470                 475                 480 


Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg Ser Glu Asp Thr Ala 
                485                 490                 495     


Ile Tyr Tyr Cys Thr Pro Leu Ser Tyr Ser Phe Asp Tyr Trp Gly Gln 
            500                 505                 510         


Gly Thr Thr Val Thr Val Ser Thr 
        515                 520 


<210>  493
<211>  1584
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0056 nt

<400>  493
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gttcctcgag cgagcccaaa tcttctgaca aaactcacac atgcccaccg      120

tgcccagcac ctgaactcct gggtggaccg tcagtcttcc tcttcccccc aaaacccaag      180

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      240

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      300

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc      360

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      420

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg      480

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg      540

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag      600

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc      660

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg      720

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtcagagg      780

cacaacaatt cttccctgaa tacaagaact cagaaagcac gtcattctcc gaattctgaa      840

attgagctca cccagtctcc agcaatcatg tctgtatttc caggggagaa ggtcaccatg      900

acctgcagtg ccagctcaat tgtacgttat atgtattggt tccagcagaa gccagggtcc      960

tcccccagac tcctgattta tgacacatcc agcctgtctt ccggagtccc tgttcgcttc     1020

agtggcagtg ggtctgggac ctcctattct ctcacaatca gccgaatgga ggctgtagat     1080

gctgccactt atttctgcca gcagtggagt agttacccac tcacgttcgg tggtgggacc     1140

aagctggaaa taaaaggggg tggaggctct ggtggcggtg gctctggcgg aggtggatcc     1200

ggtggcggcg gcggatctga ggtgcagctg gaggaatctg gaggaggctt ggtgcaacct     1260

ggagggtcca tgaaactctc ctgtgttgcc tctggattca ctttcagtaa ttcctggatg     1320

aactgggtcc gccagtctcc agaaaagggg cttgaatggg ttgctgaaat tagattgaaa     1380

tctaataatt acgcaacacg ttatgcggag tctgtgaaag ggaggttcac catctcaaga     1440

gatgattcca aaagtagtgt ctacctgcaa atgaacaact taagatctga agacactgcc     1500

atttattact gtaccccctt atcttactcc tttgactact ggggccaagg gaccacggtc     1560

accgtctcga cttgattttc taga                                            1584


<210>  494
<211>  520
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0056 aa


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(275)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (276)..(301)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (302)..(306)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (307)..(323)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (324)..(326)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (327)..(362)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (363)..(371)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (372)..(381)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (382)..(402)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (403)..(427)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (428)..(435)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (436)..(452)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (453)..(462)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (463)..(500)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (501)..(509)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (510)..(520)
<223>  Heavy region

<400>  494

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg 
                245                 250                 255     


His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg His Ser 
            260                 265                 270         


Pro Asn Ser Glu Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Val 
        275                 280                 285             


Phe Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ile Val 
    290                 295                 300                 


Arg Tyr Met Tyr Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu 
305                 310                 315                 320 


Leu Ile Tyr Asp Thr Ser Ser Leu Ser Ser Gly Val Pro Val Arg Phe 
                325                 330                 335     


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met 
            340                 345                 350         


Glu Ala Val Asp Ala Ala Thr Tyr Phe Cys Gln Gln Trp Ser Ser Tyr 
        355                 360                 365             


Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro 
                405                 410                 415     


Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser 
            420                 425                 430         


Asn Ser Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu 
        435                 440                 445             


Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr Arg Tyr 
    450                 455                 460                 


Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
465                 470                 475                 480 


Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg Ser Glu Asp Thr Ala 
                485                 490                 495     


Ile Tyr Tyr Cys Thr Pro Leu Ser Tyr Ser Phe Asp Tyr Trp Gly Gln 
            500                 505                 510         


Gly Thr Thr Val Thr Val Ser Thr 
        515                 520 


<210>  495
<211>  1887
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0087 nt

<400>  495
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gttcctcgag cgagcccaaa tcttctgaca aaactcacac atgcccaccg      120

tgcccagcac ctgaactcct gggtggaccg tcagtcttcc tcttcccccc aaaacccaag      180

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      240

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      300

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc      360

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      420

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg      480

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg      540

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag      600

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc      660

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg      720

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtcgtacg      780

cgctatctgc aggtgtctca gcagctccag cagacgaaca gggttctgga agtcactaac      840

agcagcctga ggcagcagct ccgcctcaag ataacgcagc tgggacagag tgcagaggat      900

ctgcaggggt ccaggagaga gctggcgcag agtcaggaag cactacaggt ggaacagagg      960

gctcatcagg cggccgaagg gcagctacag gcctgccagg cagacagaca gaagacgaag     1020

gagaccttgc aaagtgagga gcaacagagg agggccttgg agcagaagct gagcaacatg     1080

gagaacagac tgaagccctt cttcacatgc ggctcagcag acacctgctg tccgaattct     1140

gaaattgagc tcacccagtc tccagcaatc atgtctgtat ttccagggga gaaggtcacc     1200

atgacctgca gtgccagctc aattgtacgt tatatgtatt ggttccagca gaagccaggg     1260

tcctccccca gactcctgat ttatgacaca tccagcctgt cttccggagt ccctgttcgc     1320

ttcagtggca gtgggtctgg gacctcctat tctctcacaa tcagccgaat ggaggctgta     1380

gatgctgcca cttatttctg ccagcagtgg agtagttacc cactcacgtt cggtggtggg     1440

accaagctgg aaataaaagg gggtggaggc tctggtggcg gtggctctgg cggaggtgga     1500

tccggtggcg gcggcggatc tgaggtgcag ctggaggaat ctggaggagg cttggtgcaa     1560

cctggagggt ccatgaaact ctcctgtgtt gcctctggat tcactttcag taattcctgg     1620

atgaactggg tccgccagtc tccagaaaag gggcttgaat gggttgctga aattagattg     1680

aaatctaata attacgcaac acgttatgcg gagtctgtga aagggaggtt caccatctca     1740

agagatgatt ccaaaagtag tgtctacctg caaatgaaca acttaagatc tgaagacact     1800

gccatttatt actgtacccc cttatcttac tcctttgact actggggcca agggaccacg     1860

gtcaccgtct cgacttgatt ttctaga                                         1887


<210>  496
<211>  621
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0087 aa


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(376)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (377)..(402)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (403)..(407)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (408)..(424)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (425)..(427)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (428)..(463)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (464)..(472)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (473)..(482)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (483)..(503)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (504)..(528)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (529)..(536)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (537)..(553)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (554)..(563)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (564)..(601)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (602)..(610)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (611)..(621)
<223>  Heavy region

<400>  496

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Arg Thr 
                245                 250                 255     


Arg Tyr Leu Gln Val Ser Gln Gln Leu Gln Gln Thr Asn Arg Val Leu 
            260                 265                 270         


Glu Val Thr Asn Ser Ser Leu Arg Gln Gln Leu Arg Leu Lys Ile Thr 
        275                 280                 285             


Gln Leu Gly Gln Ser Ala Glu Asp Leu Gln Gly Ser Arg Arg Glu Leu 
    290                 295                 300                 


Ala Gln Ser Gln Glu Ala Leu Gln Val Glu Gln Arg Ala His Gln Ala 
305                 310                 315                 320 


Ala Glu Gly Gln Leu Gln Ala Cys Gln Ala Asp Arg Gln Lys Thr Lys 
                325                 330                 335     


Glu Thr Leu Gln Ser Glu Glu Gln Gln Arg Arg Ala Leu Glu Gln Lys 
            340                 345                 350         


Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr Cys Gly Ser 
        355                 360                 365             


Ala Asp Thr Cys Cys Pro Asn Ser Glu Ile Glu Leu Thr Gln Ser Pro 
    370                 375                 380                 


Ala Ile Met Ser Val Phe Pro Gly Glu Lys Val Thr Met Thr Cys Ser 
385                 390                 395                 400 


Ala Ser Ser Ile Val Arg Tyr Met Tyr Trp Phe Gln Gln Lys Pro Gly 
                405                 410                 415     


Ser Ser Pro Arg Leu Leu Ile Tyr Asp Thr Ser Ser Leu Ser Ser Gly 
            420                 425                 430         


Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        435                 440                 445             


Thr Ile Ser Arg Met Glu Ala Val Asp Ala Ala Thr Tyr Phe Cys Gln 
    450                 455                 460                 


Gln Trp Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu 
465                 470                 475                 480 


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Glu Glu Ser Gly Gly 
            500                 505                 510         


Gly Leu Val Gln Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser 
        515                 520                 525             


Gly Phe Thr Phe Ser Asn Ser Trp Met Asn Trp Val Arg Gln Ser Pro 
    530                 535                 540                 


Glu Lys Gly Leu Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn 
545                 550                 555                 560 


Tyr Ala Thr Arg Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                565                 570                 575     


Arg Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg 
            580                 585                 590         


Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Thr Pro Leu Ser Tyr Ser Phe 
        595                 600                 605             


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Thr 
    610                 615                 620     


<210>  497
<211>  1512
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0041 DNA sequence

<400>  497
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg ggtgtccacc ttgtccgaat      780

tctcaggtac agctgcagca gtcaggggct gaggtgaaga agcctgggtc ctcggtgaag      840

gtctcctgca aggcttctgg aggcaccatc agcaactatg ctatcagttg ggtgcggctg      900

gcccctggac aaggtcttga gtggatggga agtatcgtcc ctcttcatgg gacaacaaac      960

ttcgcacaga aattccaggg cagagtcacg atcaccgcgg acgagtccac gagcacatcc     1020

tacatggagg tgaacgtcct gacatatgaa gacacggcga tgtattattg tgcgtctctc     1080

aattggggct actggggccg gggcaccctg gtcaccgtct cgagtggagg cggcggttca     1140

ggcggaggtg gctctggcgg tggcggaagt gcacttaatt ttatgctgac tcagccccac     1200

tctgtgtcgg agtctccggg gaagacggta accatctcct gcaccggcag tagtggcagc     1260

attgccagca actatgtgca gtggtaccag cagcgcccgg acagtgcccc caccactgtg     1320

atctatgagg ataatcgaag atcctctgga gtccctgatc ggttctctgg ctccatcgac     1380

agctcctcca actctgcctc cctcagcatc tctggactga agactgagga cgaggctgac     1440

tactactgtc agtcctatga tagtagcggt catgtggtct tcggcggagg gaccaagctg     1500

accgtcctag gt                                                         1512


<210>  498
<211>  504
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0041 Amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(261)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (262)..(286)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (287)..(294)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (295)..(308)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (309)..(319)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (320)..(357)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (358)..(364)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (365)..(375)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (376)..(392)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (393)..(417)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (418)..(425)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (426)..(439)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (440)..(445)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (446)..(483)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (484)..(493)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (494)..(504)
<223>  Light region

<400>  498

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Cys Pro 
                245                 250                 255     


Pro Cys Pro Asn Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val 
            260                 265                 270         


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly 
        275                 280                 285             


Thr Ile Ser Asn Tyr Ala Ile Ser Trp Val Arg Leu Ala Pro Gly Gln 
    290                 295                 300                 


Gly Leu Glu Trp Met Gly Ser Ile Val Pro Leu His Gly Thr Thr Asn 
305                 310                 315                 320 


Phe Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser 
                325                 330                 335     


Thr Ser Thr Ser Tyr Met Glu Val Asn Val Leu Thr Tyr Glu Asp Thr 
            340                 345                 350         


Ala Met Tyr Tyr Cys Ala Ser Leu Asn Trp Gly Tyr Trp Gly Arg Gly 
        355                 360                 365             


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro His 
385                 390                 395                 400 


Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Gly 
                405                 410                 415     


Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg 
            420                 425                 430         


Pro Asp Ser Ala Pro Thr Thr Val Ile Tyr Glu Asp Asn Arg Arg Ser 
        435                 440                 445             


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn 
    450                 455                 460                 


Ser Ala Ser Leu Ser Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp 
465                 470                 475                 480 


Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Gly His Val Val Phe Gly Gly 
                485                 490                 495     


Gly Thr Lys Leu Thr Val Leu Gly 
            500                 


<210>  499
<211>  1554
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0042 DNA sequence

<400>  499
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct      780

tccctgaata caagaactca gaaagcacgt cattgtccga attctcaggt acagctgcag      840

cagtcagggg ctgaggtgaa gaagcctggg tcctcggtga aggtctcctg caaggcttct      900

ggaggcacca tcagcaacta tgctatcagt tgggtgcggc tggcccctgg acaaggtctt      960

gagtggatgg gaagtatcgt ccctcttcat gggacaacaa acttcgcaca gaaattccag     1020

ggcagagtca cgatcaccgc ggacgagtcc acgagcacat cctacatgga ggtgaacgtc     1080

ctgacatatg aagacacggc gatgtattat tgtgcgtctc tcaattgggg ctactggggc     1140

cggggcaccc tggtcaccgt ctcgagtgga ggcggcggtt caggcggagg tggctctggc     1200

ggtggcggaa gtgcacttaa ttttatgctg actcagcccc actctgtgtc ggagtctccg     1260

gggaagacgg taaccatctc ctgcaccggc agtagtggca gcattgccag caactatgtg     1320

cagtggtacc agcagcgccc ggacagtgcc cccaccactg tgatctatga ggataatcga     1380

agatcctctg gagtccctga tcggttctct ggctccatcg acagctcctc caactctgcc     1440

tccctcagca tctctggact gaagactgag gacgaggctg actactactg tcagtcctat     1500

gatagtagcg gtcatgtggt cttcggcgga gggaccaagc tgaccgtcct aggt           1554


<210>  500
<211>  518
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0042 Amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (23)..(38)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(275)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (276)..(300)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (301)..(308)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (309)..(322)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (323)..(333)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (334)..(371)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (372)..(378)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (379)..(389)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (390)..(406)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (407)..(431)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (432)..(439)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (440)..(453)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (454)..(459)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (460)..(497)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (498)..(507)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (508)..(518)
<223>  Light region

<400>  500

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg 
                245                 250                 255     


His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg His Cys 
            260                 265                 270         


Pro Asn Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
        275                 280                 285             


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ile 
    290                 295                 300                 


Ser Asn Tyr Ala Ile Ser Trp Val Arg Leu Ala Pro Gly Gln Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Ser Ile Val Pro Leu His Gly Thr Thr Asn Phe Ala 
                325                 330                 335     


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
            340                 345                 350         


Thr Ser Tyr Met Glu Val Asn Val Leu Thr Tyr Glu Asp Thr Ala Met 
        355                 360                 365             


Tyr Tyr Cys Ala Ser Leu Asn Trp Gly Tyr Trp Gly Arg Gly Thr Leu 
    370                 375                 380                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro His Ser Val 
                405                 410                 415     


Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Gly Ser Ser 
            420                 425                 430         


Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg Pro Asp 
        435                 440                 445             


Ser Ala Pro Thr Thr Val Ile Tyr Glu Asp Asn Arg Arg Ser Ser Gly 
    450                 455                 460                 


Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala 
465                 470                 475                 480 


Ser Leu Ser Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr 
                485                 490                 495     


Cys Gln Ser Tyr Asp Ser Ser Gly His Val Val Phe Gly Gly Gly Thr 
            500                 505                 510         


Lys Leu Thr Val Leu Gly 
        515             


<210>  501
<211>  1536
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0043 DNA sequence

<400>  501
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtctgtctgt gaaagctgac      780

ttcctcactc catccatcgg gaattctcag gtacagctgc agcagtcagg ggctgaggtg      840

aagaagcctg ggtcctcggt gaaggtctcc tgcaaggctt ctggaggcac catcagcaac      900

tatgctatca gttgggtgcg gctggcccct ggacaaggtc ttgagtggat gggaagtatc      960

gtccctcttc atgggacaac aaacttcgca cagaaattcc agggcagagt cacgatcacc     1020

gcggacgagt ccacgagcac atcctacatg gaggtgaacg tcctgacata tgaagacacg     1080

gcgatgtatt attgtgcgtc tctcaattgg ggctactggg gccggggcac cctggtcacc     1140

gtctcgagtg gaggcggcgg ttcaggcgga ggtggctctg gcggtggcgg aagtgcactt     1200

aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc     1260

tcctgcaccg gcagtagtgg cagcattgcc agcaactatg tgcagtggta ccagcagcgc     1320

ccggacagtg cccccaccac tgtgatctat gaggataatc gaagatcctc tggagtccct     1380

gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcag catctctgga     1440

ctgaagactg aggacgaggc tgactactac tgtcagtcct atgatagtag cggtcatgtg     1500

gtcttcggcg gagggaccaa gctgaccgtc ctaggt                               1536


<210>  502
<211>  512
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0043 Amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(269)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (270)..(294)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (295)..(302)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (303)..(316)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (317)..(327)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (328)..(365)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (366)..(372)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (373)..(383)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (384)..(400)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (401)..(425)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (426)..(433)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (434)..(447)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (448)..(453)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (454)..(491)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (492)..(501)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (502)..(512)
<223>  Light region

<400>  502

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Leu Ser 
                245                 250                 255     


Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser Gln Val Gln 
            260                 265                 270         


Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys 
        275                 280                 285             


Val Ser Cys Lys Ala Ser Gly Gly Thr Ile Ser Asn Tyr Ala Ile Ser 
    290                 295                 300                 


Trp Val Arg Leu Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ser Ile 
305                 310                 315                 320 


Val Pro Leu His Gly Thr Thr Asn Phe Ala Gln Lys Phe Gln Gly Arg 
                325                 330                 335     


Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ser Tyr Met Glu Val 
            340                 345                 350         


Asn Val Leu Thr Tyr Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ser Leu 
        355                 360                 365             


Asn Trp Gly Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu 
385                 390                 395                 400 


Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
                405                 410                 415     


Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn 
            420                 425                 430         


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Asp Ser Ala Pro Thr Thr Val 
        435                 440                 445             


Ile Tyr Glu Asp Asn Arg Arg Ser Ser Gly Val Pro Asp Arg Phe Ser 
    450                 455                 460                 


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Ser Ile Ser Gly 
465                 470                 475                 480 


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                485                 490                 495     


Ser Gly His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            500                 505                 510         


<210>  503
<211>  1527
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0044 DNA sequence

<400>  503
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagatgaa ctccgagttg      780

agcgtgctcg cgaattctca ggtacagctg cagcagtcag gggctgaggt gaagaagcct      840

gggtcctcgg tgaaggtctc ctgcaaggct tctggaggca ccatcagcaa ctatgctatc      900

agttgggtgc ggctggcccc tggacaaggt cttgagtgga tgggaagtat cgtccctctt      960

catgggacaa caaacttcgc acagaaattc cagggcagag tcacgatcac cgcggacgag     1020

tccacgagca catcctacat ggaggtgaac gtcctgacat atgaagacac ggcgatgtat     1080

tattgtgcgt ctctcaattg gggctactgg ggccggggca ccctggtcac cgtctcgagt     1140

ggaggcggcg gttcaggcgg aggtggctct ggcggtggcg gaagtgcact taattttatg     1200

ctgactcagc cccactctgt gtcggagtct ccggggaaga cggtaaccat ctcctgcacc     1260

ggcagtagtg gcagcattgc cagcaactat gtgcagtggt accagcagcg cccggacagt     1320

gcccccacca ctgtgatcta tgaggataat cgaagatcct ctggagtccc tgatcggttc     1380

tctggctcca tcgacagctc ctccaactct gcctccctca gcatctctgg actgaagact     1440

gaggacgagg ctgactacta ctgtcagtcc tatgatagta gcggtcatgt ggtcttcggc     1500

ggagggacca agctgaccgt cctaggt                                         1527


<210>  504
<211>  509
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0044 Amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(266)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (267)..(291)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (292)..(299)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (300)..(313)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (314)..(324)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (325)..(362)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (363)..(369)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (363)..(369)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (370)..(380)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (381)..(397)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (398)..(422)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (423)..(430)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (431)..(444)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (445)..(450)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (451)..(488)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (489)..(498)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (499)..(509)
<223>  Light region

<400>  504

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Met 
                245                 250                 255     


Asn Ser Glu Leu Ser Val Leu Ala Asn Ser Gln Val Gln Leu Gln Gln 
            260                 265                 270         


Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys 
        275                 280                 285             


Lys Ala Ser Gly Gly Thr Ile Ser Asn Tyr Ala Ile Ser Trp Val Arg 
    290                 295                 300                 


Leu Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ser Ile Val Pro Leu 
305                 310                 315                 320 


His Gly Thr Thr Asn Phe Ala Gln Lys Phe Gln Gly Arg Val Thr Ile 
                325                 330                 335     


Thr Ala Asp Glu Ser Thr Ser Thr Ser Tyr Met Glu Val Asn Val Leu 
            340                 345                 350         


Thr Tyr Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ser Leu Asn Trp Gly 
        355                 360                 365             


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Asn Phe Met 
385                 390                 395                 400 


Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr 
                405                 410                 415     


Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 
            420                 425                 430         


Trp Tyr Gln Gln Arg Pro Asp Ser Ala Pro Thr Thr Val Ile Tyr Glu 
        435                 440                 445             


Asp Asn Arg Arg Ser Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile 
    450                 455                 460                 


Asp Ser Ser Ser Asn Ser Ala Ser Leu Ser Ile Ser Gly Leu Lys Thr 
465                 470                 475                 480 


Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Gly His 
                485                 490                 495     


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            500                 505                 


<210>  505
<211>  1554
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0045 DNA sequence

<400>  505
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gggagccagc atttactcca      780

ggacccaaca tagaactcca gaaagactct gactgcccga attctcaggt acagctgcag      840

cagtcagggg ctgaggtgaa gaagcctggg tcctcggtga aggtctcctg caaggcttct      900

ggaggcacca tcagcaacta tgctatcagt tgggtgcggc tggcccctgg acaaggtctt      960

gagtggatgg gaagtatcgt ccctcttcat gggacaacaa acttcgcaca gaaattccag     1020

ggcagagtca cgatcaccgc ggacgagtcc acgagcacat cctacatgga ggtgaacgtc     1080

ctgacatatg aagacacggc gatgtattat tgtgcgtctc tcaattgggg ctactggggc     1140

cggggcaccc tggtcaccgt ctcgagtgga ggcggcggtt caggcggagg tggctctggc     1200

ggtggcggaa gtgcacttaa ttttatgctg actcagcccc actctgtgtc ggagtctccg     1260

gggaagacgg taaccatctc ctgcaccggc agtagtggca gcattgccag caactatgtg     1320

cagtggtacc agcagcgccc ggacagtgcc cccaccactg tgatctatga ggataatcga     1380

agatcctctg gagtccctga tcggttctct ggctccatcg acagctcctc caactctgcc     1440

tccctcagca tctctggact gaagactgag gacgaggctg actactactg tcagtcctat     1500

gatagtagcg gtcatgtggt cttcggcgga gggaccaagc tgaccgtcct aggt           1554


<210>  506
<211>  518
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0045 Amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(275)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (276)..(300)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (301)..(308)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (309)..(322)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (323)..(333)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (334)..(371)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (372)..(378)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (379)..(389)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (390)..(406)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (407)..(431)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (432)..(439)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (440)..(453)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (454)..(459)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (460)..(497)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (498)..(507)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (508)..(518)
<223>  Light region

<400>  506

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Glu Pro 
                245                 250                 255     


Ala Phe Thr Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser Asp Cys 
            260                 265                 270         


Pro Asn Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
        275                 280                 285             


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ile 
    290                 295                 300                 


Ser Asn Tyr Ala Ile Ser Trp Val Arg Leu Ala Pro Gly Gln Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Ser Ile Val Pro Leu His Gly Thr Thr Asn Phe Ala 
                325                 330                 335     


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
            340                 345                 350         


Thr Ser Tyr Met Glu Val Asn Val Leu Thr Tyr Glu Asp Thr Ala Met 
        355                 360                 365             


Tyr Tyr Cys Ala Ser Leu Asn Trp Gly Tyr Trp Gly Arg Gly Thr Leu 
    370                 375                 380                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Ala Leu Asn Phe Met Leu Thr Gln Pro His Ser Val 
                405                 410                 415     


Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Gly Ser Ser 
            420                 425                 430         


Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg Pro Asp 
        435                 440                 445             


Ser Ala Pro Thr Thr Val Ile Tyr Glu Asp Asn Arg Arg Ser Ser Gly 
    450                 455                 460                 


Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala 
465                 470                 475                 480 


Ser Leu Ser Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr 
                485                 490                 495     


Cys Gln Ser Tyr Asp Ser Ser Gly His Val Val Phe Gly Gly Gly Thr 
            500                 505                 510         


Lys Leu Thr Val Leu Gly 
        515             


<210>  507
<211>  1536
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0057 DNA sequence

<400>  507
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtggcggtgg ctctggtggc      780

ggtggctctg gcggtggtgg gaattctcag gtacagctgc agcagtcagg ggctgaggtg      840

aagaagcctg ggtcctcggt gaaggtctcc tgcaaggctt ctggaggcac catcagcaac      900

tatgctatca gttgggtgcg gctggcccct ggacaaggtc ttgagtggat gggaagtatc      960

gtccctcttc atgggacaac aaacttcgca cagaaattcc agggcagagt cacgatcacc     1020

gcggacgagt ccacgagcac atcctacatg gaggtgaacg tcctgacata tgaagacacg     1080

gcgatgtatt attgtgcgtc tctcaattgg ggctactggg gccggggcac cctggtcacc     1140

gtctcgagtg gaggcggcgg ttcaggcgga ggtggctctg gcggtggcgg aagtgcactt     1200

aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc     1260

tcctgcaccg gcagtagtgg cagcattgcc agcaactatg tgcagtggta ccagcagcgc     1320

ccggacagtg cccccaccac tgtgatctat gaggataatc gaagatcctc tggagtccct     1380

gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcag catctctgga     1440

ctgaagactg aggacgaggc tgactactac tgtcagtcct atgatagtag cggtcatgtg     1500

gtcttcggcg gagggaccaa gctgaccgtc ctaggt                               1536


<210>  508
<211>  512
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0057 Amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(269)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (270)..(294)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (295)..(302)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (303)..(316)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (317)..(327)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (328)..(365)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (366)..(372)
<223>  Heavy chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (373)..(383)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (384)..(400)
<223>  Hinge region (linker)

<220>
<221>  MISC_FEATURE
<222>  (401)..(425)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (426)..(433)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (434)..(447)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (448)..(453)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (454)..(491)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (492)..(501)
<223>  Light chain CDR sub-domains

<220>
<221>  MISC_FEATURE
<222>  (502)..(512)
<223>  Light region

<400>  508

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Asn Ser Gln Val Gln 
            260                 265                 270         


Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys 
        275                 280                 285             


Val Ser Cys Lys Ala Ser Gly Gly Thr Ile Ser Asn Tyr Ala Ile Ser 
    290                 295                 300                 


Trp Val Arg Leu Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ser Ile 
305                 310                 315                 320 


Val Pro Leu His Gly Thr Thr Asn Phe Ala Gln Lys Phe Gln Gly Arg 
                325                 330                 335     


Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ser Tyr Met Glu Val 
            340                 345                 350         


Asn Val Leu Thr Tyr Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ser Leu 
        355                 360                 365             


Asn Trp Gly Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu 
385                 390                 395                 400 


Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
                405                 410                 415     


Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn 
            420                 425                 430         


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Asp Ser Ala Pro Thr Thr Val 
        435                 440                 445             


Ile Tyr Glu Asp Asn Arg Arg Ser Ser Gly Val Pro Asp Arg Phe Ser 
    450                 455                 460                 


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Ser Ile Ser Gly 
465                 470                 475                 480 


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                485                 490                 495     


Ser Gly His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            500                 505                 510         


<210>  509
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide Reverse primer for 
       oligonucleotide-directed mutagenesis using PCR

<400>  509
ttcagaattc ggagaatgac gtgctttctg                                        30
<210>  510
<211>  1568
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide W0055

<400>  510
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

tcctcgagcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      120

gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct      780

tccctgaata caagaactca gaaagcacgt cattgtccga attctgaaat tgaactcacc      840

cagtctccag caatcatgtc tgtatttcca ggggagaagg tcaccatgac ctgcagtgcc      900

agctcaattg tacgttatat gtattggttc cagcagaagc cagggtcctc ccccagactc      960

ctgatttatg acacatccag cctgtcttcc tgtcttccgg agtccctgtt cgcttcagtg     1020

gcagtgggtc tgggacctcc tattctctca caatcagccg aatggaggct gtagatgctg     1080

ccacttattt ctgccagcag tggagtagtt acccactcac gttcggtggt gggaccaagc     1140

tggaaataaa agggggtgga ggctctggtg gcggtggctc tggcggaggt ggatccggtg     1200

gcggcggctc tgaggtgcag ctggaggaat ctggaggagg cttggtgcaa cctggagggt     1260

ccatgaaact ctcctgtgtt gcctctggat tcactttcag taattcctgg atgaactggg     1320

tccgccagtc tccagaaaag gggcttgaat gggttgctga aattagattg aaatctaata     1380

attatgcaac acgttatgcg gagtctgtga aagggaggtt caccatctca agagatgatt     1440

ccaaaagtag tgtctacctg caaatgaaca acttaagatc tgaagacact gccatttatt     1500

actgtacccc cttatcttac tcctttgact actggggcca agggaccacg gtcaccgtct     1560

ccagctga                                                              1568


<210>  511
<211>  520
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide W0055


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (21)..(23)
<223>  Junction

<220>
<221>  MISC_FEATURE
<222>  (24)..(38)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (39)..(254)
<223>  CH2CH3 region

<220>
<221>  MISC_FEATURE
<222>  (255)..(275)
<223>  PIMS linker

<220>
<221>  MISC_FEATURE
<222>  (276)..(301)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (302)..(306)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (307)..(323)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (324)..(326)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (327)..(362)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (363)..(371)
<223>  Light chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (372)..(381)
<223>  Light region

<220>
<221>  MISC_FEATURE
<222>  (382)..(401)
<223>  Hinge region (Linker)

<220>
<221>  MISC_FEATURE
<222>  (402)..(426)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (427)..(434)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (435)..(451)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (452)..(461)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (462)..(499)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (500)..(508)
<223>  Heavy chain CDR sub-domain

<220>
<221>  MISC_FEATURE
<222>  (509)..(519)
<223>  Heavy region

<220>
<221>  MISC_FEATURE
<222>  (520)..(520)
<223>  Xaa is a stop codon

<400>  511

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg 
                245                 250                 255     


His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg His Cys 
            260                 265                 270         


Pro Asn Ser Glu Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Val 
        275                 280                 285             


Phe Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ile Val 
    290                 295                 300                 


Arg Tyr Met Tyr Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu 
305                 310                 315                 320 


Leu Ile Tyr Asp Thr Ser Ser Leu Ser Ser Gly Val Pro Val Arg Phe 
                325                 330                 335     


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met 
            340                 345                 350         


Glu Ala Val Asp Ala Ala Thr Tyr Phe Cys Gln Gln Trp Ser Ser Tyr 
        355                 360                 365             


Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                405                 410                 415     


Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn 
            420                 425                 430         


Ser Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp 
        435                 440                 445             


Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr Arg Tyr Ala 
    450                 455                 460                 


Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser 
465                 470                 475                 480 


Ser Val Tyr Leu Gln Met Asn Asn Leu Arg Ser Glu Asp Thr Ala Ile 
                485                 490                 495     


Tyr Tyr Cys Thr Pro Leu Ser Tyr Ser Phe Asp Tyr Trp Gly Gln Gly 
            500                 505                 510         


Thr Thr Val Thr Val Ser Ser Xaa 
        515                 520 


<210>  512
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H10

<400>  512

Glu Pro Lys Ser Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  513
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H14

<400>  513

Gly Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Asn Ser 
1               5                   10              


<210>  514
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H34

<400>  514

Gly Cys Pro Pro Cys Pro Gly Asn Ser 
1               5                   


<210>  515
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H35

<400>  515

Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Gly Asn Ser 
1               5                   10              


<210>  516
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H41

<400>  516

Gly Cys Pro Pro Cys Pro Ala Asn Ser 
1               5                   


<210>  517
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H42

<400>  517

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  518
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H43

<400>  518

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  519
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H47

<400>  519

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10                  15  


<210>  520
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H48

<400>  520

Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10          


<210>  521
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H50

<400>  521

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  522
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H51

<400>  522

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  523
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H52

<400>  523

Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ser 
1               5                   10      


<210>  524
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H53

<400>  524

Ser Gln Pro Glu Ile Val Pro Ile Ser Cys Pro Pro Cys Pro Asn Ser 
1               5                   10                  15      


<210>  525
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H54

<400>  525

Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro Cys 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  526
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H55

<400>  526

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10                  15  


<210>  527
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H56

<400>  527

Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10          


<210>  528
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H57

<400>  528

Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 
1               5                   10  


<210>  529
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H58

<400>  529

Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 
1               5                   10                  15  


<210>  530
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H59

<400>  530

Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 
1               5                   10                  15  


<210>  531
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H60

<400>  531

Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe Ser Met Pro Asn Ser 
1               5                   10                  15  


<210>  532
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H61

<400>  532

Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser 
1               5                   10                  15      


Asp Cys Pro Asn Ser 
            20      


<210>  533
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H62

<400>  533

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg 
1               5                   10                  15      


His Cys Pro Asn Ser 
            20      


<210>  534
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H63

<400>  534

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  535
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H64

<400>  535

Arg Thr Arg Tyr Leu Gln Val Ser Gln Gln Leu Gln Gln Thr Asn Arg 
1               5                   10                  15      


Val Leu Glu Val Thr Asn Ser Ser Leu Arg Gln Gln Leu Arg Leu Lys 
            20                  25                  30          


Ile Thr Gln Leu Gly Gln Ser Ala Glu Asp Leu Gln Gly Ser Arg Arg 
        35                  40                  45              


Glu Leu Ala Gln Ser Gln Glu Ala Leu Gln Val Glu Gln Arg Ala His 
    50                  55                  60                  


Gln Ala Ala Glu Gly Gln Leu Gln Ala Cys Gln Ala Asp Arg Gln Lys 
65                  70                  75                  80  


Thr Lys Glu Thr Leu Gln Ser Glu Glu Gln Gln Arg Arg Ala Leu Glu 
                85                  90                  95      


Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr Cys 
            100                 105                 110         


Gly Ser Ala Asp Thr Cys Cys Pro Asn Ser 
        115                 120         


<210>  536
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H65

<400>  536

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  537
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H66

<400>  537

Glu Glu Glu Glu Asp Glu Gly Asn Ser 
1               5                   


<210>  538
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H67

<400>  538

Glu Glu Glu Glu Asp Glu Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu 
1               5                   10                  15      


Asp Gly Asn Ser 
            20  


<210>  539
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400>  539

Gly Gly Gly Gly Ser 
1               5   


<210>  540
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400>  540

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  541
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker STD3

<400>  541

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Ser 
            20  


<210>  542
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker STD4

<400>  542

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Ser Asn Ser 
        35      


<210>  543
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H9

<400>  543

Gly Ser Pro Pro Ser Pro Asn Ser 
1               5               


<210>  544
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide llinker H11

<400>  544

Glu Pro Lys Ser Thr Asp Lys Thr His Thr Ser Pro Pro Ser Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  545
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H12

<400>  545

Glu Pro Lys Ser Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  546
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H17a

<400>  546

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Ser Pro Pro Cys 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  547
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H45a

<400>  547

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser 
1               5                   10              


<210>  548
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker H46a

<400>  548

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser 
1               5                   10              


<210>  549
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  549
ttcagaattc ggagaatgac gtgctttctg                                      30

