                         SEQUENCE LISTING

<110>  BAYLOR COLLEGE OF MEDICINE
       Pownall , Henry J.
 
<120>  A METHOD OF DELIPIDATION OF HDL USING SERUM OPACITY FACTOR TO 
       PREVENT, INHIBIT, AND/OR REVERSE ATHEROSCLEROSIS

<130>  HO-P03522WO0

<140>  TBA
<141>  2008-08-22

<150>  60/957,282
<151>  2007-08-22

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1026
<212>  PRT
<213>  Human

<400>  1

Met Thr Asn Cys Lys Tyr Lys Leu Arg Lys Leu Ser Val Gly Leu Val 
1               5                   10                  15      


Ser Val Gly Thr Met Leu Ile Ala Pro Thr Val Leu Gly Gln Glu Val 
            20                  25                  30          


Ser Ala Ser Ser Ser Thr Glu Ser Ser Thr Thr Thr Ala Asn Thr Gly 
        35                  40                  45              


Thr Gly Thr Ala Ser Gly Met Thr Ala Thr Thr Pro Ser Ala Thr Thr 
    50                  55                  60                  


Asp Thr Gly Glu Ala Ala Gly Ser Gly Ala Arg Ser Glu Ala Asn Gly 
65                  70                  75                  80  


Ala Ser Ser Val Val Ser Ser Glu Glu Ser Gln Ser Ser Gly Thr Thr 
                85                  90                  95      


Pro Ala Ser Pro Gln Ala Gln Thr Ala Pro Ala Ala Thr Ser Thr Ser 
            100                 105                 110         


Ser Val Ser Ser Ser Asn Glu Lys Thr Pro Lys Thr Ala Thr Thr Thr 
        115                 120                 125             


Thr Ser Ser Thr Pro Val Ala Ser Thr Ser Asn Asn Ser Asn Lys Val 
    130                 135                 140                 


Thr Ser Thr Glu Ala Glu Thr Gln Thr Val Asp Val Glu Arg Tyr Thr 
145                 150                 155                 160 


Val Asp Lys Glu Asn Ser Lys Leu Asn Ile Lys Asp Gly Lys Thr Pro 
                165                 170                 175     


Lys Thr Arg Ser Ser Val Asn Lys Asp Thr Lys Leu Ile Arg Asn Arg 
            180                 185                 190         


Asp Asp Lys Gln Arg Asp Ile Val Asp Val Thr Arg Thr Val Glu Thr 
        195                 200                 205             


Asn Glu Asp Gly Leu Leu Met Phe Thr Gly Asn Gly Leu Lys Pro Lys 
    210                 215                 220                 


Gln Ile Asp Glu Gly Ala Asp Val Met Ala Leu Leu Asp Val Ser Gln 
225                 230                 235                 240 


Lys Met Thr Lys Glu Asn Phe Asp Lys Ala Lys Glu Gln Ile Lys Lys 
                245                 250                 255     


Met Val Thr Thr Leu Thr Gly Glu Pro Thr Asp Gly Lys Glu Asn His 
            260                 265                 270         


Asn Arg Arg Asn Ser Val Arg Leu Met Thr Phe Tyr Arg Lys Val Asn 
        275                 280                 285             


Glu Pro Ile Glu Leu Thr Ala Glu Asn Val Asp Lys Thr Leu Asp Glu 
    290                 295                 300                 


Val Trp Lys Lys Ala Lys Glu Asp Trp Asp Trp Gly Val Asp Leu Gln 
305                 310                 315                 320 


Gly Ala Ile His Lys Ala Arg Glu Ile Phe Asn Lys Glu Lys Glu Lys 
                325                 330                 335     


Lys Ser Gly Lys Arg Gln His Ile Val Leu Phe Ser Gln Gly Glu Ser 
            340                 345                 350         


Thr Phe Ser Tyr Asp Ile Lys Asn Lys Met Ile Leu Gln Lys Leu Pro 
        355                 360                 365             


Ile Thr Glu Lys Val Thr Thr Ser Ser Pro Leu Phe Pro Trp Leu Pro 
    370                 375                 380                 


Ile Phe Asn His Thr Asn Arg Lys Ala Glu Ile Ile Gly Asp Leu Glu 
385                 390                 395                 400 


Lys Val Leu Asp Met Ala Glu Lys Val Gly Ile Ser Leu Pro Ser Ser 
                405                 410                 415     


Leu Lys Ser Ala Val Lys Val Leu Gly Leu Thr Asn Ser Ala Ile Gly 
            420                 425                 430         


Ser Ile Leu Gly Lys Gly Leu Thr Glu Tyr Leu Gly Leu Thr Glu Tyr 
        435                 440                 445             


Ser Ser Asp Asn Leu Asp Gly Gly Gly Phe Asp Tyr Ser Lys Arg Val 
    450                 455                 460                 


Gly Glu Gly Tyr Tyr Tyr His Ser Leu Ser Asp Arg Lys Tyr Glu Asn 
465                 470                 475                 480 


Thr Met Pro Leu Glu Glu Ala Ile Arg Thr Ala Leu Ala Ser Asn Phe 
                485                 490                 495     


Pro Lys Leu Thr Asp Asn Trp Phe Phe Asp Ile Leu Asn Ser Phe Val 
            500                 505                 510         


Asn Lys Asp Thr Val Glu Lys Ala Lys Leu Asp Val Ile Met Lys Val 
        515                 520                 525             


Leu Asn Ser Ile Phe Tyr Lys Lys Glu Tyr Arg Tyr Tyr Asn His Asn 
    530                 535                 540                 


Leu Ser Ala Ile Ala Glu Ala Lys Met Ala Gln Gln Glu Gly Ile Thr 
545                 550                 555                 560 


Phe Tyr Ser Val Asp Val Thr Asp Leu Asn Ser Ala Ser Lys Arg Val 
                565                 570                 575     


Arg Arg Gln Ala Ala Val Arg Lys Gly Thr Lys Glu Glu Asn Lys Lys 
            580                 585                 590         


Asn Glu Glu Glu Arg Asn Thr Lys Phe Asp Thr Tyr Leu Lys Lys Met 
        595                 600                 605             


Ser Glu Gly Asn Asn Phe Leu Ser Asn Val Glu Glu Arg Asp Phe Phe 
    610                 615                 620                 


Lys Asp Thr Leu Thr Glu Leu Thr Ile Lys Asp Glu Phe Thr Asp Lys 
625                 630                 635                 640 


Val Thr Val Glu Lys Asp Ser Trp Ser Lys Ser Ile Thr Asp Gly Leu 
                645                 650                 655     


Lys Asn Ser Asn Asn Asn Asn Val Lys His Gln Gln Ala Asn Thr Ser 
            660                 665                 670         


Thr Trp Ser Phe Phe Ser Ser Ser Lys Glu Ser Leu Thr Trp Ile Ile 
        675                 680                 685             


Ser Lys Glu Ala Leu Lys Glu Thr Phe Glu Lys Asn Gly Ser Leu Thr 
    690                 695                 700                 


Phe Lys Tyr Lys Leu Arg Val Asn Lys Asp Lys Leu Leu Asp Leu Asp 
705                 710                 715                 720 


Lys Lys Glu Thr Lys Arg Asp Thr Ser Thr Glu Asn Lys Thr Ser Val 
                725                 730                 735     


Thr Ala Asn Ile Ile Ser Asn Thr Val Asn Tyr Lys Ile Asn Asn Gln 
            740                 745                 750         


Glu Val Lys Gly Asn Lys Leu Asp Ala Val Asn Leu Thr Tyr Thr Lys 
        755                 760                 765             


Glu Thr Val Pro Val Pro Asp Val Glu Gly Glu Val Val Pro Ile Pro 
    770                 775                 780                 


Glu Lys Pro Leu Val Glu Pro Met Thr Pro Leu Tyr Pro Ala Ile Pro 
785                 790                 795                 800 


Asn Tyr Pro Thr Pro Gln Leu Pro Lys Asp Glu Asp Leu Glu Ile Ser 
                805                 810                 815     


Gly Gly His Gly Pro Ile Val Asp Ile Val Glu Asp Thr Gly Ala Gly 
            820                 825                 830         


Val Glu Gly Gly Ala Gln Asn Gly Val Val Ser Thr Gln Glu Asn Lys 
        835                 840                 845             


Asp Pro Ile Val Asp Ile Thr Glu Asp Thr Gln Pro Gly Met Ser Gly 
    850                 855                 860                 


Ser Asn Asp Ala Thr Val Val Glu Glu Asp Thr Ala Pro Lys Arg Pro 
865                 870                 875                 880 


Asp Val Leu Val Gly Gly Gln Ser Asp Pro Ile Asp Ile Thr Glu Asp 
                885                 890                 895     


Thr Gln Pro Gly Met Ser Gly Ser Asn Asp Ala Thr Val Ile Glu Glu 
            900                 905                 910         


Asp Thr Ala Pro Lys Arg Pro Asp Val Leu Val Gly Gly Gln Cys Asp 
        915                 920                 925             


Pro Ile Asp Ile Thr Glu Asp Thr Gln Pro Gly Met Ser Gly Ser Asn 
    930                 935                 940                 


Asp Ala Thr Val Ile Glu Asp Asp Thr Lys Pro Lys Arg Phe Phe His 
945                 950                 955                 960 


Phe Asp Asn Glu Pro Gln Ala Pro Glu Lys Pro Lys Glu Gln Pro Ser 
                965                 970                 975     


Leu Ser Leu Pro Gln Ala Pro Val Tyr Lys Ala Ala His His Leu Pro 
            980                 985                 990         


Ala Ser Gly Asp Lys Arg Glu Ala  Ser Phe Thr Ile Val  Ala Leu Thr 
        995                 1000                 1005             


Ile Ile  Gly Ala Ala Gly Leu  Leu Ser Lys Lys Arg  Arg Asp Thr 
    1010                 1015                 1020             


Glu Glu  Asn 
    1025     


<210>  2
<211>  3081
<212>  DNA
<213>  Human

<400>  2
atgacaaatt gtaagtataa acttagaaag ttatctgtag ggctcgtctc cgtcggaacg       60

atgctgatag ccccgacagt tttaggacag gaggttagtg ctagtagtag tacggagagc      120

agtaccacta cagctaatac tggtaccggt acggcaagtg ggatgactgc cactactcct      180

agtgctacga cagatactgg tgaagcagct gggagcggag ctaggagtga agctaatggt      240

gcatcgtccg tagtatctag cgaagaaagt cagagttcag gcactactcc agcctcaccc      300

caagcacaga cagctccagc agcaacgtca acatcatcgg tttcttctag taatgagaaa      360

actcccaaga cagcaactac aactacatca tcgactccag tagcaagtac cagtaataat      420

agcaacaaag taactagtac tgaagctgaa acacagacgg tggacgtgga acggtataca      480

gttgataagg aaaattcaaa gctaaatatt aaagacggta agactccaaa aactaggagt      540

agtgttaata aagacacaaa acttattaga aaccgcgatg acaaacagcg tgatatcgtt      600

gatgttactc ggacagttga aactaacgaa gatggcctat tgatgtttac cggtaacggg      660

ttaaaaccga agcaaattga cgaaggtgcc gatgttatgg cccttctaga tgtctctcaa      720

aagatgacaa aagagaattt tgataaggct aaagaacaaa taaaaaaaat ggttacgact      780

ttaacaggcg agccaactga tggtaaggaa aatcataata ggcgtaattc tgtacgtcta      840

atgacttttt accgtaaggt taatgagcct atcgaattga ctgctgaaaa tgtagacaaa      900

acattagatg aagtttggaa aaaagctaaa gaagattggg actggggcgt tgacttacag      960

ggagctatcc ataaagctcg agagattttt aataaggaaa aagaaaaaaa atcgggtaaa     1020

cgccagcata tcgtcttgtt ctctcaaggc gaatcaacct ttagttatga tattaaaaat     1080

aaaatgatat tacaaaaact acccataact gaaaaagtta cgacctctag cccactgttt     1140

ccttggctcc ctatctttaa tcacactaac cgaaaggcag agattattgg tgatttagaa     1200

aaagtactag acatggccga aaaagtggga ataagtttac ctagtagtct gaagtcggca     1260

gtgaaagtcc ttggcttaac taatagtgca ataggttcta ttttagggaa aggtttgaca     1320

gagtaccttg gtttgacaga atatagttca gataacttag atggaggagg gtttgattat     1380

agtaaacgtg taggggaagg ttactactac cacagtttat cagataggaa atatgaaaat     1440

acaatgcccc ttgaagaagc tatcaggacg gccttagcat ctaattttcc caaactcaca     1500

gataattggt ttttcgatat cttaaatagt tttgtcaata aagatacagt tgagaaagct     1560

aaattagacg taattatgaa ggtacttaat agtatttttt acaaaaaaga atatcgctat     1620

tacaaccata acctgtcagc aatagccgaa gctaaaatgg ctcaacaaga gggcattacc     1680

ttctattccg ttgatgttac tgatttaaac tcagcttcta aaagagtgag gcgacaagca     1740

gcagtgcgta agggcactaa ggaagaaaac aaaaaaaatg aagaagagcg taatacaaag     1800

tttgacacct atctgaaaaa gatgtctgaa ggtaataatt tcttaagtaa tgttgaagag     1860

agagattttt tcaaagatac tttaacagag ctgacaatta aagacgaatt tacggataaa     1920

gttacggtcg agaaggattc ctggagtaaa tctataactg atggacttaa aaattcaaat     1980

aacaataatg ttaaacatca acaggcaaac acatcgacat ggagtttctt cagttcatcc     2040

aaagaaagcc tcacctggat catttccaaa gaagcactca aagaaacctt tgagaaaaat     2100

ggttctctca cttttaaata caaattacgg gtcaataaag acaaactatt agatttagat     2160

aagaaagaga caaaacgtga tacatctacg gaaaataaaa cttctgtaac ggcaaatatc     2220

atttcaaata ctgttaacta caaaattaat aatcaagaag ttaagggtaa caaacttgat     2280

gctgtcaatt tgacttatac taaagagacc gttcctgttc cagatgtgga aggagaagtt     2340

gtaccaatac cagaaaaacc actggtagaa ccaatgacgc ctctataccc tgcaattcct     2400

aattacccta cccctcaact tccaaaagat gaagatctgg agattagtgg aggtcatgga     2460

ccgattgtcg atatcgtcga agatactggt gcaggtgttg agggcggcgc tcaaaatggt     2520

gtggtttcaa ctcaggaaaa taaagatcca atagttgaca tcaccgaaga tacccaacca     2580

ggtatgtcag gctcaaatga cgcgacagtt gtcgaggaag acacagcacc taaacgtcca     2640

gatgtccttg ttggtggtca aagtgatcca atcgatatca ccgaagatac ccaaccaggc     2700

atgtcaggtt ctaatgacgc tactgttatc gaggaagaca cagcacctaa acgtccagat     2760

gtccttgttg gtggtcaatg tgatccaatc gatatcaccg aagataccca accaggcatg     2820

tcaggttcta atgacgctac tgttatcgaa gatgatacga aaccaaaacg cttcttccac     2880

tttgataacg agccacaagc accagaaaaa cctaaagagc aaccatctct cagcttacca     2940

caagctccag tatataaggc agctcatcac ttgcctgcat ctggagacaa acgtgaagca     3000

tcctttacaa ttgttgctct aacaattatt ggagctgcag gtttgctcag caaaaaacgt     3060

cgcgacaccg aagaaaacta a                                               3081


<210>  3
<211>  806
<212>  PRT
<213>  Human

<400>  3

Thr Glu Ser Ser Thr Thr Thr Ala Asn Thr Gly Thr Gly Thr Ala Ser 
1               5                   10                  15      


Gly Met Thr Ala Thr Thr Pro Ser Ala Thr Thr Asp Thr Gly Glu Ala 
            20                  25                  30          


Ala Gly Ser Gly Ala Arg Ser Glu Ala Asn Gly Ala Ser Ser Val Val 
        35                  40                  45              


Ser Ser Glu Glu Ser Gln Ser Ser Gly Thr Thr Pro Ala Ser Pro Gln 
    50                  55                  60                  


Ala Gln Thr Ala Pro Ala Ala Thr Ser Thr Ser Ser Val Ser Ser Ser 
65                  70                  75                  80  


Asn Glu Lys Thr Pro Lys Thr Ala Thr Thr Thr Thr Ser Ser Thr Pro 
                85                  90                  95      


Val Ala Ser Thr Ser Asn Asn Ser Asn Lys Val Thr Ser Thr Glu Ala 
            100                 105                 110         


Glu Thr Gln Thr Val Asp Val Glu Arg Tyr Thr Val Asp Lys Glu Asn 
        115                 120                 125             


Ser Lys Leu Asn Ile Lys Asp Gly Lys Thr Pro Lys Thr Arg Ser Ser 
    130                 135                 140                 


Val Asn Lys Asp Thr Lys Leu Ile Arg Asn Arg Asp Asp Lys Gln Arg 
145                 150                 155                 160 


Asp Ile Val Asp Val Thr Arg Thr Val Glu Thr Asn Glu Asp Gly Leu 
                165                 170                 175     


Leu Met Phe Thr Gly Asn Gly Leu Lys Pro Lys Gln Ile Asp Glu Gly 
            180                 185                 190         


Ala Asp Val Met Ala Leu Leu Asp Val Ser Gln Lys Met Thr Lys Glu 
        195                 200                 205             


Asn Phe Asp Lys Ala Lys Glu Gln Ile Lys Lys Met Val Thr Thr Leu 
    210                 215                 220                 


Thr Gly Glu Pro Thr Asp Gly Lys Glu Asn His Asn Arg Arg Asn Ser 
225                 230                 235                 240 


Val Arg Leu Met Thr Phe Tyr Arg Lys Val Asn Glu Pro Ile Glu Leu 
                245                 250                 255     


Thr Ala Glu Asn Val Asp Lys Thr Leu Asp Glu Val Trp Lys Lys Ala 
            260                 265                 270         


Lys Glu Asp Trp Asp Trp Gly Val Asp Leu Gln Gly Ala Ile His Lys 
        275                 280                 285             


Ala Arg Glu Ile Phe Asn Lys Glu Lys Glu Lys Lys Ser Gly Lys Arg 
    290                 295                 300                 


Gln His Ile Val Leu Phe Ser Gln Gly Glu Ser Thr Phe Ser Tyr Asp 
305                 310                 315                 320 


Ile Lys Asn Lys Met Ile Leu Gln Lys Leu Pro Ile Thr Glu Lys Val 
                325                 330                 335     


Thr Thr Ser Ser Pro Leu Phe Pro Trp Leu Pro Ile Phe Asn His Thr 
            340                 345                 350         


Asn Arg Lys Ala Glu Ile Ile Gly Asp Leu Glu Lys Val Leu Asp Met 
        355                 360                 365             


Ala Glu Lys Val Gly Ile Ser Leu Pro Ser Ser Leu Lys Ser Ala Val 
    370                 375                 380                 


Lys Val Leu Gly Leu Thr Asn Ser Ala Ile Gly Ser Ile Leu Gly Lys 
385                 390                 395                 400 


Gly Leu Thr Glu Tyr Leu Gly Leu Thr Glu Tyr Ser Ser Asp Asn Leu 
                405                 410                 415     


Asp Gly Gly Gly Phe Asp Tyr Ser Lys Arg Val Gly Glu Gly Tyr Tyr 
            420                 425                 430         


Tyr His Ser Leu Ser Asp Arg Lys Tyr Glu Asn Thr Met Pro Leu Glu 
        435                 440                 445             


Glu Ala Ile Arg Thr Ala Leu Ala Ser Asn Phe Pro Lys Leu Thr Asp 
    450                 455                 460                 


Asn Trp Phe Phe Asp Ile Leu Asn Ser Phe Val Asn Lys Asp Thr Val 
465                 470                 475                 480 


Glu Lys Ala Lys Leu Asp Val Ile Met Lys Val Leu Asn Ser Ile Phe 
                485                 490                 495     


Tyr Lys Lys Glu Tyr Arg Tyr Tyr Asn His Asn Leu Ser Ala Ile Ala 
            500                 505                 510         


Glu Ala Lys Met Ala Gln Gln Glu Gly Ile Thr Phe Tyr Ser Val Asp 
        515                 520                 525             


Val Thr Asp Leu Asn Ser Ala Ser Lys Arg Val Arg Arg Gln Ala Ala 
    530                 535                 540                 


Val Arg Lys Gly Thr Lys Glu Glu Asn Lys Lys Asn Glu Glu Glu Arg 
545                 550                 555                 560 


Asn Thr Lys Phe Asp Thr Tyr Leu Lys Lys Met Ser Glu Gly Asn Asn 
                565                 570                 575     


Phe Leu Ser Asn Val Glu Glu Arg Asp Phe Phe Lys Asp Thr Leu Thr 
            580                 585                 590         


Glu Leu Thr Ile Lys Asp Glu Phe Thr Asp Lys Val Thr Val Glu Lys 
        595                 600                 605             


Asp Ser Trp Ser Lys Ser Ile Thr Asp Gly Leu Lys Asn Ser Asn Asn 
    610                 615                 620                 


Asn Asn Val Lys His Gln Gln Ala Asn Thr Ser Thr Trp Ser Phe Phe 
625                 630                 635                 640 


Ser Ser Ser Lys Glu Ser Leu Thr Trp Ile Ile Ser Lys Glu Ala Leu 
                645                 650                 655     


Lys Glu Thr Phe Glu Lys Asn Gly Ser Leu Thr Phe Lys Tyr Lys Leu 
            660                 665                 670         


Arg Val Asn Lys Asp Lys Leu Leu Asp Leu Asp Lys Lys Glu Thr Lys 
        675                 680                 685             


Arg Asp Thr Ser Thr Glu Asn Lys Thr Ser Val Thr Ala Asn Ile Ile 
    690                 695                 700                 


Ser Asn Thr Val Asn Tyr Lys Ile Asn Asn Gln Glu Val Lys Gly Asn 
705                 710                 715                 720 


Lys Leu Asp Ala Val Asn Leu Thr Tyr Thr Lys Glu Thr Val Pro Val 
                725                 730                 735     


Pro Asp Val Glu Gly Glu Val Val Pro Ile Pro Glu Lys Pro Leu Val 
            740                 745                 750         


Glu Pro Met Thr Pro Leu Tyr Pro Ala Ile Pro Asn Tyr Pro Thr Pro 
        755                 760                 765             


Gln Leu Pro Lys Asp Glu Asp Leu Glu Ile Ser Gly Gly His Gly Pro 
    770                 775                 780                 


Ile Val Asp Ile Val Glu Asp Thr Gly Ala Gly Val Glu Gly Gly Ala 
785                 790                 795                 800 


Gln Asn Gly Val Val Ser 
                805     


<210>  4
<211>  2418
<212>  DNA
<213>  Human

<400>  4
acggagagca gtaccactac agctaatact ggtaccggta cggcaagtgg gatgactgcc       60

actactccta gtgctacgac agatactggt gaagcagctg ggagcggagc taggagtgaa      120

gctaatggtg catcgtccgt agtatctagc gaagaaagtc agagttcagg cactactcca      180

gcctcacccc aagcacagac agctccagca gcaacgtcaa catcatcggt ttcttctagt      240

aatgagaaaa ctcccaagac agcaactaca actacatcat cgactccagt agcaagtacc      300

agtaataata gcaacaaagt aactagtact gaagctgaaa cacagacggt ggacgtggaa      360

cggtatacag ttgataagga aaattcaaag ctaaatatta aagacggtaa gactccaaaa      420

actaggagta gtgttaataa agacacaaaa cttattagaa accgcgatga caaacagcgt      480

gatatcgttg atgttactcg gacagttgaa actaacgaag atggcctatt gatgtttacc      540

ggtaacgggt taaaaccgaa gcaaattgac gaaggtgccg atgttatggc ccttctagat      600

gtctctcaaa agatgacaaa agagaatttt gataaggcta aagaacaaat aaaaaaaatg      660

gttacgactt taacaggcga gccaactgat ggtaaggaaa atcataatag gcgtaattct      720

gtacgtctaa tgacttttta ccgtaaggtt aatgagccta tcgaattgac tgctgaaaat      780

gtagacaaaa cattagatga agtttggaaa aaagctaaag aagattggga ctggggcgtt      840

gacttacagg gagctatcca taaagctcga gagattttta ataaggaaaa agaaaaaaaa      900

tcgggtaaac gccagcatat cgtcttgttc tctcaaggcg aatcaacctt tagttatgat      960

attaaaaata aaatgatatt acaaaaacta cccataactg aaaaagttac gacctctagc     1020

ccactgtttc cttggctccc tatctttaat cacactaacc gaaaggcaga gattattggt     1080

gatttagaaa aagtactaga catggccgaa aaagtgggaa taagtttacc tagtagtctg     1140

aagtcggcag tgaaagtcct tggcttaact aatagtgcaa taggttctat tttagggaaa     1200

ggtttgacag agtaccttgg tttgacagaa tatagttcag ataacttaga tggaggaggg     1260

tttgattata gtaaacgtgt aggggaaggt tactactacc acagtttatc agataggaaa     1320

tatgaaaata caatgcccct tgaagaagct atcaggacgg ccttagcatc taattttccc     1380

aaactcacag ataattggtt tttcgatatc ttaaatagtt ttgtcaataa agatacagtt     1440

gagaaagcta aattagacgt aattatgaag gtacttaata gtatttttta caaaaaagaa     1500

tatcgctatt acaaccataa cctgtcagca atagccgaag ctaaaatggc tcaacaagag     1560

ggcattacct tctattccgt tgatgttact gatttaaact cagcttctaa aagagtgagg     1620

cgacaagcag cagtgcgtaa gggcactaag gaagaaaaca aaaaaaatga agaagagcgt     1680

aatacaaagt ttgacaccta tctgaaaaag atgtctgaag gtaataattt cttaagtaat     1740

gttgaagaga gagatttttt caaagatact ttaacagagc tgacaattaa agacgaattt     1800

acggataaag ttacggtcga gaaggattcc tggagtaaat ctataactga tggacttaaa     1860

aattcaaata acaataatgt taaacatcaa caggcaaaca catcgacatg gagtttcttc     1920

agttcatcca aagaaagcct cacctggatc atttccaaag aagcactcaa agaaaccttt     1980

gagaaaaatg gttctctcac ttttaaatac aaattacggg tcaataaaga caaactatta     2040

gatttagata agaaagagac aaaacgtgat acatctacgg aaaataaaac ttctgtaacg     2100

gcaaatatca tttcaaatac tgttaactac aaaattaata atcaagaagt taagggtaac     2160

aaacttgatg ctgtcaattt gacttatact aaagagaccg ttcctgttcc agatgtggaa     2220

ggagaagttg taccaatacc agaaaaacca ctggtagaac caatgacgcc tctataccct     2280

gcaattccta attaccctac ccctcaactt ccaaaagatg aagatctgga gattagtgga     2340

ggtcatggac cgattgtcga tatcgtcgaa gatactggtg caggtgttga gggcggcgct     2400

caaaatggtg tggtttca                                                   2418


