                         SEQUENCE LISTING

<110>  DANG, THAO P.
       CARBONE, DAVID P.
       MERNAUGH, RAY
 
<120>  TARGETING OF NOTCH3 RECEPTOR FUNCTION FOR CANCER THERAPY

<130>  VBLT:121WO

<140>  UNKNOWN
<141>  2008-09-11

<150>  60/972,584
<151>  2007-09-14

<160>  10    

<170>  PatentIn version 3.3

<210>  1
<211>  8091
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (79)..(7044)

<400>  1
acgcggcgcg gaggctggcc cgggacgcgc ccggagccca gggaaggagg gaggagggga     60

gggtcgcggc cggccgcc atg ggg ccg ggg gcc cgt ggc cgc cgc cgc cgc      111
                    Met Gly Pro Gly Ala Arg Gly Arg Arg Arg Arg         
                    1               5                   10              

cgt cgc ccg atg tcg ccg cca ccg cca ccg cca ccc gtg cgg gcg ctg      159
Arg Arg Pro Met Ser Pro Pro Pro Pro Pro Pro Pro Val Arg Ala Leu         
            15                  20                  25                  

ccc ctg ctg ctg ctg cta gcg ggg ccg ggg gct gca gcc ccc cct tgc      207
Pro Leu Leu Leu Leu Leu Ala Gly Pro Gly Ala Ala Ala Pro Pro Cys         
        30                  35                  40                      

ctg gac gga agc ccg tgt gca aat gga ggt cgt tgc acc cag ctg ccc      255
Leu Asp Gly Ser Pro Cys Ala Asn Gly Gly Arg Cys Thr Gln Leu Pro         
    45                  50                  55                          

tcc cgg gag gct gcc tgc ctg tgc ccg cct ggc tgg gtg ggt gag cgg      303
Ser Arg Glu Ala Ala Cys Leu Cys Pro Pro Gly Trp Val Gly Glu Arg         
60                  65                  70                  75          

tgt cag ctg gag gac ccc tgt cac tca ggc ccc tgt gct ggc cgt ggt      351
Cys Gln Leu Glu Asp Pro Cys His Ser Gly Pro Cys Ala Gly Arg Gly         
                80                  85                  90              

gtc tgc cag agt tca gtg gtg gct ggc acc gcc cga ttc tca tgc cgg      399
Val Cys Gln Ser Ser Val Val Ala Gly Thr Ala Arg Phe Ser Cys Arg         
            95                  100                 105                 

tgc ccc cgt ggc ttc cga ggc cct gac tgc tcc ctg cca gat ccc tgc      447
Cys Pro Arg Gly Phe Arg Gly Pro Asp Cys Ser Leu Pro Asp Pro Cys         
        110                 115                 120                     

ctc agc agc cct tgt gcc cac ggt gcc cgc tgc tca gtg ggg ccc gat      495
Leu Ser Ser Pro Cys Ala His Gly Ala Arg Cys Ser Val Gly Pro Asp         
    125                 130                 135                         

gga cgc ttc ctc tgc tcc tgc cca cct ggc tac cag ggc cgc agc tgc      543
Gly Arg Phe Leu Cys Ser Cys Pro Pro Gly Tyr Gln Gly Arg Ser Cys         
140                 145                 150                 155         

cga agc gac gtg gat gag tgc cgg gtg ggt gag ccc tgc cgc cat ggt      591
Arg Ser Asp Val Asp Glu Cys Arg Val Gly Glu Pro Cys Arg His Gly         
                160                 165                 170             

ggc acc tgc ctc aac aca cct ggc tcc ttc cgc tgc cag tgt cca gct      639
Gly Thr Cys Leu Asn Thr Pro Gly Ser Phe Arg Cys Gln Cys Pro Ala         
            175                 180                 185                 

ggc tac aca ggg cca cta tgt gag aac ccc gcg gtg ccc tgt gcg ccc      687
Gly Tyr Thr Gly Pro Leu Cys Glu Asn Pro Ala Val Pro Cys Ala Pro         
        190                 195                 200                     

tca cca tgc cgt aac ggg ggc acc tgc agg cag agt ggc gac ctc act      735
Ser Pro Cys Arg Asn Gly Gly Thr Cys Arg Gln Ser Gly Asp Leu Thr         
    205                 210                 215                         

tac gac tgt gcc tgt ctt cct ggg ttt gag ggt cag aat tgt gaa gtg      783
Tyr Asp Cys Ala Cys Leu Pro Gly Phe Glu Gly Gln Asn Cys Glu Val         
220                 225                 230                 235         

aac gtg gac gac tgt cca gga cac cga tgt ctc aat ggg ggg aca tgc      831
Asn Val Asp Asp Cys Pro Gly His Arg Cys Leu Asn Gly Gly Thr Cys         
                240                 245                 250             

gtg gat ggc gtc aac acc tat aac tgc cag tgc cct cct gag tgg aca      879
Val Asp Gly Val Asn Thr Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr         
            255                 260                 265                 

ggc cag ttc tgc acg gag gac gtg gat gag tgt cag ctg cag ccc aac      927
Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Gln Pro Asn         
        270                 275                 280                     

gcc tgc cac aat ggg ggt acc tgc ttc aac acg ctg ggt ggc cac agc      975
Ala Cys His Asn Gly Gly Thr Cys Phe Asn Thr Leu Gly Gly His Ser         
    285                 290                 295                         

tgc gtg tgt gtc aat ggc tgg aca ggt gag agc tgc agt cag aat atc     1023
Cys Val Cys Val Asn Gly Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile         
300                 305                 310                 315         

gat gac tgt gcc aca gcc gtg tgc ttc cat ggg gcc acc tgc cat gac     1071
Asp Asp Cys Ala Thr Ala Val Cys Phe His Gly Ala Thr Cys His Asp         
                320                 325                 330             

cgc gtg gct tct ttc tac tgt gcc tgc ccc atg ggc aag act ggc ctc     1119
Arg Val Ala Ser Phe Tyr Cys Ala Cys Pro Met Gly Lys Thr Gly Leu         
            335                 340                 345                 

ctg tgt cac ctg gat gac gcc tgt gtc agc aac ccc tgc cac gag gat     1167
Leu Cys His Leu Asp Asp Ala Cys Val Ser Asn Pro Cys His Glu Asp         
        350                 355                 360                     

gct atc tgt gac aca aat ccg gtg aac ggc cgg gcc att tgc acc tgt     1215
Ala Ile Cys Asp Thr Asn Pro Val Asn Gly Arg Ala Ile Cys Thr Cys         
    365                 370                 375                         

cct ccc ggc ttc acg ggt ggg gca tgt gac cag gat gtg gac gag tgc     1263
Pro Pro Gly Phe Thr Gly Gly Ala Cys Asp Gln Asp Val Asp Glu Cys         
380                 385                 390                 395         

tct atc ggc gcc aac ccc tgc gag cac ttg ggc agg tgc gtg aac acg     1311
Ser Ile Gly Ala Asn Pro Cys Glu His Leu Gly Arg Cys Val Asn Thr         
                400                 405                 410             

cag ggc tcc ttc ctg tgc cag tgc ggt cgt ggc tac act gga cct cgc     1359
Gln Gly Ser Phe Leu Cys Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg         
            415                 420                 425                 

tgt gag acc gat gtc aac gag tgt ctg tcg ggg ccc tgc cga aac cag     1407
Cys Glu Thr Asp Val Asn Glu Cys Leu Ser Gly Pro Cys Arg Asn Gln         
        430                 435                 440                     

gcc acg tgc ctc gac cgc ata ggc cag ttc acc tgt atc tgt atg gca     1455
Ala Thr Cys Leu Asp Arg Ile Gly Gln Phe Thr Cys Ile Cys Met Ala         
    445                 450                 455                         

ggc ttc aca gga acc tat tgc gag gtg gac att gac gag tgt cag agt     1503
Gly Phe Thr Gly Thr Tyr Cys Glu Val Asp Ile Asp Glu Cys Gln Ser         
460                 465                 470                 475         

agc ccc tgt gtc aac ggt ggg gtc tgc aag gac cga gtc aat ggc ttc     1551
Ser Pro Cys Val Asn Gly Gly Val Cys Lys Asp Arg Val Asn Gly Phe         
                480                 485                 490             

agc tgc acc tgc ccc tcg ggc ttc agc ggc tcc acg tgt cag ctg gac     1599
Ser Cys Thr Cys Pro Ser Gly Phe Ser Gly Ser Thr Cys Gln Leu Asp         
            495                 500                 505                 

gtg gac gaa tgc gcc agc acg ccc tgc agg aat ggc gcc aaa tgc gtg     1647
Val Asp Glu Cys Ala Ser Thr Pro Cys Arg Asn Gly Ala Lys Cys Val         
        510                 515                 520                     

gac cag ccc gat ggc tac gag tgc cgc tgt gcc gag ggc ttt gag ggc     1695
Asp Gln Pro Asp Gly Tyr Glu Cys Arg Cys Ala Glu Gly Phe Glu Gly         
    525                 530                 535                         

acg ctg tgt gat cgc aac gtg gac gac tgc tcc cct gac cca tgc cac     1743
Thr Leu Cys Asp Arg Asn Val Asp Asp Cys Ser Pro Asp Pro Cys His         
540                 545                 550                 555         

cat ggt cgc tgc gtg gat ggc atc gcc agc ttc tca tgt gcc tgt gct     1791
His Gly Arg Cys Val Asp Gly Ile Ala Ser Phe Ser Cys Ala Cys Ala         
                560                 565                 570             

cct ggc tac acg ggc aca cgc tgc gag agc cag gtg gac gaa tgc cgc     1839
Pro Gly Tyr Thr Gly Thr Arg Cys Glu Ser Gln Val Asp Glu Cys Arg         
            575                 580                 585                 

agc cag ccc tgc cgc cat ggc ggc aaa tgc cta gac ctg gtg gac aag     1887
Ser Gln Pro Cys Arg His Gly Gly Lys Cys Leu Asp Leu Val Asp Lys         
        590                 595                 600                     

tac ctc tgc cgc tgc cct tct ggg acc aca ggt gtg aac tgc gaa gtg     1935
Tyr Leu Cys Arg Cys Pro Ser Gly Thr Thr Gly Val Asn Cys Glu Val         
    605                 610                 615                         

aac att gac gac tgt gcc agc aac ccc tgc acc ttt gga gtc tgc cgt     1983
Asn Ile Asp Asp Cys Ala Ser Asn Pro Cys Thr Phe Gly Val Cys Arg         
620                 625                 630                 635         

gat ggc atc aac cgc tac gac tgt gtc tgc caa cct ggc ttc aca ggg     2031
Asp Gly Ile Asn Arg Tyr Asp Cys Val Cys Gln Pro Gly Phe Thr Gly         
                640                 645                 650             

ccc ctt tgt aac gtg gag atc aat gag tgt gct tcc agc cca tgc ggc     2079
Pro Leu Cys Asn Val Glu Ile Asn Glu Cys Ala Ser Ser Pro Cys Gly         
            655                 660                 665                 

gag gga ggt tcc tgt gtg gat ggg gaa aat ggc ttc cgc tgc ctc tgc     2127
Glu Gly Gly Ser Cys Val Asp Gly Glu Asn Gly Phe Arg Cys Leu Cys         
        670                 675                 680                     

ccg cct ggc tcc ttg ccc cca ctc tgc ctc ccc ccg agc cat ccc tgt     2175
Pro Pro Gly Ser Leu Pro Pro Leu Cys Leu Pro Pro Ser His Pro Cys         
    685                 690                 695                         

gcc cat gag ccc tgc agt cac ggc atc tgc tat gat gca cct ggc ggg     2223
Ala His Glu Pro Cys Ser His Gly Ile Cys Tyr Asp Ala Pro Gly Gly         
700                 705                 710                 715         

ttc cgc tgt gtg tgt gag cct ggc tgg agt ggc ccc cgc tgc agc cag     2271
Phe Arg Cys Val Cys Glu Pro Gly Trp Ser Gly Pro Arg Cys Ser Gln         
                720                 725                 730             

agc ctg gcc cga gac gcc tgt gag tcc cag ccg tgc agg gcc ggt ggg     2319
Ser Leu Ala Arg Asp Ala Cys Glu Ser Gln Pro Cys Arg Ala Gly Gly         
            735                 740                 745                 

aca tgc agc agc gat gga atg ggt ttc cac tgc acc tgc ccg cct ggt     2367
Thr Cys Ser Ser Asp Gly Met Gly Phe His Cys Thr Cys Pro Pro Gly         
        750                 755                 760                     

gtc cag gga cgt cag tgt gaa ctc ctc tcc ccc tgc acc ccg aac ccc     2415
Val Gln Gly Arg Gln Cys Glu Leu Leu Ser Pro Cys Thr Pro Asn Pro         
    765                 770                 775                         

tgt gag cat ggg ggc cgc tgc gag tct gcc cct ggc cag ctg cct gtc     2463
Cys Glu His Gly Gly Arg Cys Glu Ser Ala Pro Gly Gln Leu Pro Val         
780                 785                 790                 795         

tgc tcc tgc ccc cag ggc tgg caa ggc cca cga tgc cag cag gat gtg     2511
Cys Ser Cys Pro Gln Gly Trp Gln Gly Pro Arg Cys Gln Gln Asp Val         
                800                 805                 810             

gac gag tgt gct ggc ccc gca ccc tgt ggc cct cat ggt atc tgc acc     2559
Asp Glu Cys Ala Gly Pro Ala Pro Cys Gly Pro His Gly Ile Cys Thr         
            815                 820                 825                 

aac ctg gca ggg agt ttc agc tgc acc tgc cat gga ggg tac act ggc     2607
Asn Leu Ala Gly Ser Phe Ser Cys Thr Cys His Gly Gly Tyr Thr Gly         
        830                 835                 840                     

cct tcc tgt gat cag gac atc aat gac tgt gac ccc aac cca tgc ctg     2655
Pro Ser Cys Asp Gln Asp Ile Asn Asp Cys Asp Pro Asn Pro Cys Leu         
    845                 850                 855                         

aac ggt ggc tcg tgc caa gac ggc gtg ggc tcc ttt tcc tgc tcc tgc     2703
Asn Gly Gly Ser Cys Gln Asp Gly Val Gly Ser Phe Ser Cys Ser Cys         
860                 865                 870                 875         

ctc cct ggt ttc gcc ggc cca cga tgc gcc cgc gat gtg gat gag tgc     2751
Leu Pro Gly Phe Ala Gly Pro Arg Cys Ala Arg Asp Val Asp Glu Cys         
                880                 885                 890             

ctg agc aac ccc tgc ggc ccg ggc acc tgt acc gac cac gtg gcc tcc     2799
Leu Ser Asn Pro Cys Gly Pro Gly Thr Cys Thr Asp His Val Ala Ser         
            895                 900                 905                 

ttc acc tgc acc tgc ccg ccg ggc tac gga ggc ttc cac tgc gaa cag     2847
Phe Thr Cys Thr Cys Pro Pro Gly Tyr Gly Gly Phe His Cys Glu Gln         
        910                 915                 920                     

gac ctg ccc gac tgc agc ccc agc tcc tgc ttc aat ggc ggg acc tgt     2895
Asp Leu Pro Asp Cys Ser Pro Ser Ser Cys Phe Asn Gly Gly Thr Cys         
    925                 930                 935                         

gtg gac ggc gtg aac tcg ttc agc tgc ctg tgc cgt ccc ggc tac aca     2943
Val Asp Gly Val Asn Ser Phe Ser Cys Leu Cys Arg Pro Gly Tyr Thr         
940                 945                 950                 955         

gga gcc cac tgc caa cat gag gca gac ccc tgc ctc tcg cgg ccc tgc     2991
Gly Ala His Cys Gln His Glu Ala Asp Pro Cys Leu Ser Arg Pro Cys         
                960                 965                 970             

cta cac ggg ggc gtc tgc agc gcc gcc cac cct ggc ttc cgc tgc acc     3039
Leu His Gly Gly Val Cys Ser Ala Ala His Pro Gly Phe Arg Cys Thr         
            975                 980                 985                 

tgc ctc gag agc ttc acg ggc ccg cag tgc cag acg ctg  gtg gat tgg    3087
Cys Leu Glu Ser Phe Thr Gly Pro Gln Cys Gln Thr Leu  Val Asp Trp        
        990                 995                 1000                    

tgc agc  cgc cag cct tgt caa  aac ggg ggt cgc tgc  gtc cag act      3132
Cys Ser  Arg Gln Pro Cys Gln  Asn Gly Gly Arg Cys  Val Gln Thr          
    1005                 1010                 1015                      

ggg gcc  tat tgc ctt tgt ccc  cct gga tgg agc gga  cgc ctc tgt      3177
Gly Ala  Tyr Cys Leu Cys Pro  Pro Gly Trp Ser Gly  Arg Leu Cys          
    1020                 1025                 1030                      

gac atc  cga agc ttg ccc tgc  agg gag gcc gca gcc  cag atc ggg      3222
Asp Ile  Arg Ser Leu Pro Cys  Arg Glu Ala Ala Ala  Gln Ile Gly          
    1035                 1040                 1045                      

gtg cgg  ctg gag cag ctg tgt  cag gcg ggt ggg cag  tgt gtg gat      3267
Val Arg  Leu Glu Gln Leu Cys  Gln Ala Gly Gly Gln  Cys Val Asp          
    1050                 1055                 1060                      

gaa gac  agc tcc cac tac tgc  gtg tgc cca gag ggc  cgt act ggt      3312
Glu Asp  Ser Ser His Tyr Cys  Val Cys Pro Glu Gly  Arg Thr Gly          
    1065                 1070                 1075                      

agc cac  tgt gag cag gag gtg  gac ccc tgc ttg gcc  cag ccc tgc      3357
Ser His  Cys Glu Gln Glu Val  Asp Pro Cys Leu Ala  Gln Pro Cys          
    1080                 1085                 1090                      

cag cat  ggg ggg acc tgc cgt  ggc tat atg ggg ggc  tac atg tgt      3402
Gln His  Gly Gly Thr Cys Arg  Gly Tyr Met Gly Gly  Tyr Met Cys          
    1095                 1100                 1105                      

gag tgt  ctt cct ggc tac aat  ggt gat aac tgt gag  gac gac gtg      3447
Glu Cys  Leu Pro Gly Tyr Asn  Gly Asp Asn Cys Glu  Asp Asp Val          
    1110                 1115                 1120                      

gac gag  tgt gcc tcc cag ccc  tgc cag cac ggg ggt  tca tgc att      3492
Asp Glu  Cys Ala Ser Gln Pro  Cys Gln His Gly Gly  Ser Cys Ile          
    1125                 1130                 1135                      

gac ctc  gtg gcc cgc tat ctc  tgc tcc tgt ccc cca  gga acg ctg      3537
Asp Leu  Val Ala Arg Tyr Leu  Cys Ser Cys Pro Pro  Gly Thr Leu          
    1140                 1145                 1150                      

ggg gtg  ctc tgc gag att aat  gag gat gac tgc ggc  cca ggc cca      3582
Gly Val  Leu Cys Glu Ile Asn  Glu Asp Asp Cys Gly  Pro Gly Pro          
    1155                 1160                 1165                      

ccg ctg  gac tca ggg ccc cgg  tgc cta cac aat ggc  acc tgc gtg      3627
Pro Leu  Asp Ser Gly Pro Arg  Cys Leu His Asn Gly  Thr Cys Val          
    1170                 1175                 1180                      

gac ctg  gtg ggt ggt ttc cgc  tgc acc tgt ccc cca  gga tac act      3672
Asp Leu  Val Gly Gly Phe Arg  Cys Thr Cys Pro Pro  Gly Tyr Thr          
    1185                 1190                 1195                      

ggt ttg  cgc tgc gag gca gac  atc aat gag tgt cgc  tca ggt gcc      3717
Gly Leu  Arg Cys Glu Ala Asp  Ile Asn Glu Cys Arg  Ser Gly Ala          
    1200                 1205                 1210                      

tgc cac  gcg gca cac acc cgg  gac tgc ctg cag gac  cca ggc gga      3762
Cys His  Ala Ala His Thr Arg  Asp Cys Leu Gln Asp  Pro Gly Gly          
    1215                 1220                 1225                      

ggt ttc  cgt tgc ctt tgt cat  gct ggc ttc tca ggt  cct cgc tgt      3807
Gly Phe  Arg Cys Leu Cys His  Ala Gly Phe Ser Gly  Pro Arg Cys          
    1230                 1235                 1240                      

cag act  gtc ctg tct ccc tgc  gag tcc cag cca tgc  cag cat gga      3852
Gln Thr  Val Leu Ser Pro Cys  Glu Ser Gln Pro Cys  Gln His Gly          
    1245                 1250                 1255                      

ggc cag  tgc cgt cct agc ccg  ggt cct ggg ggt ggg  ctg acc ttc      3897
Gly Gln  Cys Arg Pro Ser Pro  Gly Pro Gly Gly Gly  Leu Thr Phe          
    1260                 1265                 1270                      

acc tgt  cac tgt gcc cag ccg  ttc tgg ggt ccg cgt  tgc gag cgg      3942
Thr Cys  His Cys Ala Gln Pro  Phe Trp Gly Pro Arg  Cys Glu Arg          
    1275                 1280                 1285                      

gtg gcg  cgc tcc tgc cgg gag  ctg cag tgc ccg gtg  ggc gtc cca      3987
Val Ala  Arg Ser Cys Arg Glu  Leu Gln Cys Pro Val  Gly Val Pro          
    1290                 1295                 1300                      

tgc cag  cag acg ccc cgc ggg  ccg cgc tgc gcc tgc  ccc cca ggg      4032
Cys Gln  Gln Thr Pro Arg Gly  Pro Arg Cys Ala Cys  Pro Pro Gly          
    1305                 1310                 1315                      

ttg tcg  gga ccc tcc tgc cgc  agc ttc ccg ggg tcg  ccg ccg ggg      4077
Leu Ser  Gly Pro Ser Cys Arg  Ser Phe Pro Gly Ser  Pro Pro Gly          
    1320                 1325                 1330                      

gcc agc  aac gcc agc tgc gcg  gcc gcc ccc tgt ctc  cac ggg ggc      4122
Ala Ser  Asn Ala Ser Cys Ala  Ala Ala Pro Cys Leu  His Gly Gly          
    1335                 1340                 1345                      

tcc tgc  cgc ccc gcg ccg ctc  gcg ccc ttc ttc cgc  tgc gct tgc      4167
Ser Cys  Arg Pro Ala Pro Leu  Ala Pro Phe Phe Arg  Cys Ala Cys          
    1350                 1355                 1360                      

gcg cag  ggc tgg acc ggg ccg  cgc tgc gag gcg ccc  gcc gcg gca      4212
Ala Gln  Gly Trp Thr Gly Pro  Arg Cys Glu Ala Pro  Ala Ala Ala          
    1365                 1370                 1375                      

ccc gag  gtc tcg gag gag ccg  cgg tgc ccg cgc gcc  gcc tgc cag      4257
Pro Glu  Val Ser Glu Glu Pro  Arg Cys Pro Arg Ala  Ala Cys Gln          
    1380                 1385                 1390                      

gcc aag  cgc ggg gac cag cgc  tgc gac cgc gag tgc  aac agc cca      4302
Ala Lys  Arg Gly Asp Gln Arg  Cys Asp Arg Glu Cys  Asn Ser Pro          
    1395                 1400                 1405                      

ggc tgc  ggc tgg gac ggc ggc  gac tgc tcg ctg agc  gtg ggc gac      4347
Gly Cys  Gly Trp Asp Gly Gly  Asp Cys Ser Leu Ser  Val Gly Asp          
    1410                 1415                 1420                      

ccc tgg  cgg caa tgc gag gcg  ctg cag tgc tgg cgc  ctc ttc aac      4392
Pro Trp  Arg Gln Cys Glu Ala  Leu Gln Cys Trp Arg  Leu Phe Asn          
    1425                 1430                 1435                      

aac agc  cgc tgc gac ccc gcc  tgc agc tcg ccc gcc  tgc ctc tac      4437
Asn Ser  Arg Cys Asp Pro Ala  Cys Ser Ser Pro Ala  Cys Leu Tyr          
    1440                 1445                 1450                      

gac aac  ttc gac tgc cac gcc  ggt ggc cgc gag cgc  act tgc aac      4482
Asp Asn  Phe Asp Cys His Ala  Gly Gly Arg Glu Arg  Thr Cys Asn          
    1455                 1460                 1465                      

ccg gtg  tac gag aag tac tgc  gcc gac cac ttt gcc  gac ggc cgc      4527
Pro Val  Tyr Glu Lys Tyr Cys  Ala Asp His Phe Ala  Asp Gly Arg          
    1470                 1475                 1480                      

tgc gac  cag ggc tgc aac acg  gag gag tgc ggc tgg  gat ggg ctg      4572
Cys Asp  Gln Gly Cys Asn Thr  Glu Glu Cys Gly Trp  Asp Gly Leu          
    1485                 1490                 1495                      

gat tgt  gcc agc gag gtg ccg  gcc ctg ctg gcc cgc  ggc gtg ctg      4617
Asp Cys  Ala Ser Glu Val Pro  Ala Leu Leu Ala Arg  Gly Val Leu          
    1500                 1505                 1510                      

gtg ctc  aca gtg ctg ctg ccg  ccg gag gag cta ctg  cgt tcc agc      4662
Val Leu  Thr Val Leu Leu Pro  Pro Glu Glu Leu Leu  Arg Ser Ser          
    1515                 1520                 1525                      

gcc gac  ttt ctg cag cgg ctc  agc gcc atc ctg cgc  acc tcg ctg      4707
Ala Asp  Phe Leu Gln Arg Leu  Ser Ala Ile Leu Arg  Thr Ser Leu          
    1530                 1535                 1540                      

cgc ttc  cgc ctg gac gcg cac  ggc cag gcc atg gtc  ttc cct tac      4752
Arg Phe  Arg Leu Asp Ala His  Gly Gln Ala Met Val  Phe Pro Tyr          
    1545                 1550                 1555                      

cac cgg  cct agt cct ggc tcc  gaa ccc cgg gcc cgt  cgg gag ctg      4797
His Arg  Pro Ser Pro Gly Ser  Glu Pro Arg Ala Arg  Arg Glu Leu          
    1560                 1565                 1570                      

gcc ccc  gag gtg atc ggc tcg  gta gta atg ctg gag  att gac aac      4842
Ala Pro  Glu Val Ile Gly Ser  Val Val Met Leu Glu  Ile Asp Asn          
    1575                 1580                 1585                      

cgg ctc  tgc ctg cag tcg cct  gag aat gat cac tgc  ttc ccc gat      4887
Arg Leu  Cys Leu Gln Ser Pro  Glu Asn Asp His Cys  Phe Pro Asp          
    1590                 1595                 1600                      

gcc cag  agc gcc gct gac tac  ctg gga gcg ttg tca  gcg gtg gag      4932
Ala Gln  Ser Ala Ala Asp Tyr  Leu Gly Ala Leu Ser  Ala Val Glu          
    1605                 1610                 1615                      

cgc ctg  gac ttc ccg tac cca  ctg cgg gac gtg cgg  ggg gag ccg      4977
Arg Leu  Asp Phe Pro Tyr Pro  Leu Arg Asp Val Arg  Gly Glu Pro          
    1620                 1625                 1630                      

ctg gag  cct cca gaa ccc agc  gtc ccg ctg ctg cca  ctg cta gtg      5022
Leu Glu  Pro Pro Glu Pro Ser  Val Pro Leu Leu Pro  Leu Leu Val          
    1635                 1640                 1645                      

gcg ggc  gct gtc ttg ctg ctg  gtc att ctc gtc ctg  ggt gtc atg      5067
Ala Gly  Ala Val Leu Leu Leu  Val Ile Leu Val Leu  Gly Val Met          
    1650                 1655                 1660                      

gtg gcc  cgg cgc aag cgc gag  cac agc acc ctc tgg  ttc cct gag      5112
Val Ala  Arg Arg Lys Arg Glu  His Ser Thr Leu Trp  Phe Pro Glu          
    1665                 1670                 1675                      

ggc ttc  tca ctg cac aag gac  gtg gcc tct ggt cac  aag ggc cgg      5157
Gly Phe  Ser Leu His Lys Asp  Val Ala Ser Gly His  Lys Gly Arg          
    1680                 1685                 1690                      

cgg gaa  ccc gtg ggc cag gac  gcg ctg ggc atg aag  aac atg gcc      5202
Arg Glu  Pro Val Gly Gln Asp  Ala Leu Gly Met Lys  Asn Met Ala          
    1695                 1700                 1705                      

aag ggt  gag agc ctg atg ggg  gag gtg gcc aca gac  tgg atg gac      5247
Lys Gly  Glu Ser Leu Met Gly  Glu Val Ala Thr Asp  Trp Met Asp          
    1710                 1715                 1720                      

aca gag  tgc cca gag gcc aag  cgg cta aag gta gag  gag cca ggc      5292
Thr Glu  Cys Pro Glu Ala Lys  Arg Leu Lys Val Glu  Glu Pro Gly          
    1725                 1730                 1735                      

atg ggg  gct gag gag gct gtg  gat tgc cgt cag tgg  act caa cac      5337
Met Gly  Ala Glu Glu Ala Val  Asp Cys Arg Gln Trp  Thr Gln His          
    1740                 1745                 1750                      

cat ctg  gtt gct gct gac atc  cgc gtg gca cca gcc  atg gca ctg      5382
His Leu  Val Ala Ala Asp Ile  Arg Val Ala Pro Ala  Met Ala Leu          
    1755                 1760                 1765                      

aca cca  cca cag ggc gac gca  gat gct gat ggc atg  gat gtc aat      5427
Thr Pro  Pro Gln Gly Asp Ala  Asp Ala Asp Gly Met  Asp Val Asn          
    1770                 1775                 1780                      

gtg cgt  ggc cca gat ggc ttc  acc ccg cta atg ctg  gct tcc ttc      5472
Val Arg  Gly Pro Asp Gly Phe  Thr Pro Leu Met Leu  Ala Ser Phe          
    1785                 1790                 1795                      

tgt ggg  ggg gct ctg gag cca  atg cca act gaa gag  gat gag gca      5517
Cys Gly  Gly Ala Leu Glu Pro  Met Pro Thr Glu Glu  Asp Glu Ala          
    1800                 1805                 1810                      

gat gac  aca tca gct agc atc  atc tcc gac ctg atc  tgc cag ggg      5562
Asp Asp  Thr Ser Ala Ser Ile  Ile Ser Asp Leu Ile  Cys Gln Gly          
    1815                 1820                 1825                      

gct cag  ctt ggg gca cgg act  gac cgt act ggc gag  act gct ttg      5607
Ala Gln  Leu Gly Ala Arg Thr  Asp Arg Thr Gly Glu  Thr Ala Leu          
    1830                 1835                 1840                      

cac ctg  gct gcc cgt tat gcc  cgt gct gat gca gcc  aag cgg ctg      5652
His Leu  Ala Ala Arg Tyr Ala  Arg Ala Asp Ala Ala  Lys Arg Leu          
    1845                 1850                 1855                      

ctg gat  gct ggg gca gac acc  aat gcc cag gac cac  tca ggc cgc      5697
Leu Asp  Ala Gly Ala Asp Thr  Asn Ala Gln Asp His  Ser Gly Arg          
    1860                 1865                 1870                      

act ccc  ctg cac aca gct gtc  aca gcc gat gcc cag  ggt gtc ttc      5742
Thr Pro  Leu His Thr Ala Val  Thr Ala Asp Ala Gln  Gly Val Phe          
    1875                 1880                 1885                      

cag att  ctc atc cga aac cgc  tct aca gac ttg gat  gcc cgc atg      5787
Gln Ile  Leu Ile Arg Asn Arg  Ser Thr Asp Leu Asp  Ala Arg Met          
    1890                 1895                 1900                      

gca gat  ggc tca acg gca ctg  atc ctg gcg gcc cgc  ctg gca gta      5832
Ala Asp  Gly Ser Thr Ala Leu  Ile Leu Ala Ala Arg  Leu Ala Val          
    1905                 1910                 1915                      

gag ggc  atg gtg gaa gag ctc  atc gcc agc cat gct  gat gtc aat      5877
Glu Gly  Met Val Glu Glu Leu  Ile Ala Ser His Ala  Asp Val Asn          
    1920                 1925                 1930                      

gct gtg  gat gag ctt ggg aaa  tca gcc tta cac tgg  gct gcg gct      5922
Ala Val  Asp Glu Leu Gly Lys  Ser Ala Leu His Trp  Ala Ala Ala          
    1935                 1940                 1945                      

gtg aac  aac gtg gaa gcc act  ttg gcc ctg ctc aaa  aat gga gcc      5967
Val Asn  Asn Val Glu Ala Thr  Leu Ala Leu Leu Lys  Asn Gly Ala          
    1950                 1955                 1960                      

aat aag  gac atg cag gat agc  aag gag gag acc ccc  cta ttc ctg      6012
Asn Lys  Asp Met Gln Asp Ser  Lys Glu Glu Thr Pro  Leu Phe Leu          
    1965                 1970                 1975                      

gcc gcc  cgc gag ggc agc tat  gag gct gcc aag ctg  ctg ttg gac      6057
Ala Ala  Arg Glu Gly Ser Tyr  Glu Ala Ala Lys Leu  Leu Leu Asp          
    1980                 1985                 1990                      

cac ttt  gcc aac cgt gag atc  acc gac cac ctg gac  agg ctg ccg      6102
His Phe  Ala Asn Arg Glu Ile  Thr Asp His Leu Asp  Arg Leu Pro          
    1995                 2000                 2005                      

cgg gac  gta gcc cag gag aga  ctg cac cag gac atc  gtg cgc ttg      6147
Arg Asp  Val Ala Gln Glu Arg  Leu His Gln Asp Ile  Val Arg Leu          
    2010                 2015                 2020                      

ctg gat  caa ccc agt ggg ccc  cgc agc ccc ccc ggt  ccc cac ggc      6192
Leu Asp  Gln Pro Ser Gly Pro  Arg Ser Pro Pro Gly  Pro His Gly          
    2025                 2030                 2035                      

ctg ggg  cct ctg ctc tgt cct  cca ggg gcc ttc ctc  cct ggc ctc      6237
Leu Gly  Pro Leu Leu Cys Pro  Pro Gly Ala Phe Leu  Pro Gly Leu          
    2040                 2045                 2050                      

aaa gcg  gca cag tcg ggg tcc  aag aag agc agg agg  ccc ccc ggg      6282
Lys Ala  Ala Gln Ser Gly Ser  Lys Lys Ser Arg Arg  Pro Pro Gly          
    2055                 2060                 2065                      

aag gcg  ggg ctg ggg ccg cag  ggg ccc cgg ggg cgg  ggc aag aag      6327
Lys Ala  Gly Leu Gly Pro Gln  Gly Pro Arg Gly Arg  Gly Lys Lys          
    2070                 2075                 2080                      

ctg acg  ctg gcc tgc ccg ggc  ccc ctg gct gac agc  tcg gtc acg      6372
Leu Thr  Leu Ala Cys Pro Gly  Pro Leu Ala Asp Ser  Ser Val Thr          
    2085                 2090                 2095                      

ctg tcg  ccc gtg gac tcg ctg  gac tcc ccg cgg cct  ttc ggt ggg      6417
Leu Ser  Pro Val Asp Ser Leu  Asp Ser Pro Arg Pro  Phe Gly Gly          
    2100                 2105                 2110                      

ccc cct  gct tcc cct ggt ggc  ttc ccc ctt gag ggg  ccc tat gca      6462
Pro Pro  Ala Ser Pro Gly Gly  Phe Pro Leu Glu Gly  Pro Tyr Ala          
    2115                 2120                 2125                      

gct gcc  act gcc act gca gtg  tct ctg gca cag ctt  ggt ggc cca      6507
Ala Ala  Thr Ala Thr Ala Val  Ser Leu Ala Gln Leu  Gly Gly Pro          
    2130                 2135                 2140                      

ggc cgg  gca ggt cta ggg cgc  cag ccc cct gga gga  tgt gta ctc      6552
Gly Arg  Ala Gly Leu Gly Arg  Gln Pro Pro Gly Gly  Cys Val Leu          
    2145                 2150                 2155                      

agc ctg  ggc ctg ctg aac cct  gtg gct gtg ccc ctc  gat tgg gcc      6597
Ser Leu  Gly Leu Leu Asn Pro  Val Ala Val Pro Leu  Asp Trp Ala          
    2160                 2165                 2170                      

cgg ctg  ccc cca cct gcc cct  cca ggc ccc tcg ttc  ctg ctg cca      6642
Arg Leu  Pro Pro Pro Ala Pro  Pro Gly Pro Ser Phe  Leu Leu Pro          
    2175                 2180                 2185                      

ctg gcg  ccg gga ccc cag ctg  ctc aac cca ggg acc  ccc gtc tcc      6687
Leu Ala  Pro Gly Pro Gln Leu  Leu Asn Pro Gly Thr  Pro Val Ser          
    2190                 2195                 2200                      

ccg cag  gag cgg ccc ccg cct  tac ctg gca gtc cca  gga cat ggc      6732
Pro Gln  Glu Arg Pro Pro Pro  Tyr Leu Ala Val Pro  Gly His Gly          
    2205                 2210                 2215                      

gag gag  tac ccg gtg gct ggg  gca cac agc agc ccc  cca aag gcc      6777
Glu Glu  Tyr Pro Val Ala Gly  Ala His Ser Ser Pro  Pro Lys Ala          
    2220                 2225                 2230                      

cgc ttc  ctg cgg gtt ccc agt  gag cac cct tac ctg  acc cca tcc      6822
Arg Phe  Leu Arg Val Pro Ser  Glu His Pro Tyr Leu  Thr Pro Ser          
    2235                 2240                 2245                      

ccc gaa  tcc cct gag cac tgg  gcc agc ccc tca cct  ccc tcc ctc      6867
Pro Glu  Ser Pro Glu His Trp  Ala Ser Pro Ser Pro  Pro Ser Leu          
    2250                 2255                 2260                      

tca gac  tgg tcc gaa tcc acg  cct agc cca gcc act  gcc act ggg      6912
Ser Asp  Trp Ser Glu Ser Thr  Pro Ser Pro Ala Thr  Ala Thr Gly          
    2265                 2270                 2275                      

gcc atg  gcc acc acc act ggg  gca ctg cct gcc cag  cca ctt ccc      6957
Ala Met  Ala Thr Thr Thr Gly  Ala Leu Pro Ala Gln  Pro Leu Pro          
    2280                 2285                 2290                      

ttg tct  gtt ccc agc tcc ctt  gct cag gcc cag acc  cag ctg ggg      7002
Leu Ser  Val Pro Ser Ser Leu  Ala Gln Ala Gln Thr  Gln Leu Gly          
    2295                 2300                 2305                      

ccc cag  ccg gaa gtt acc ccc  aag agg caa gtg ttg  gcc tga          7044
Pro Gln  Pro Glu Val Thr Pro  Lys Arg Gln Val Leu  Ala                  
    2310                 2315                 2320                      

gacgctcgtc agttcttaga tcttgggggc ctaaagagac ccccgtcctg cctcctttct   7104

ttctctgtct cttccttcct tttagtcttt ttcatcctct tctctttcca ccaaccctcc   7164

tgcatccttg ccttgcagcg tgaccgagat aggtcatcag cccagggctt cagtcttcct   7224

ttatttataa tgggtggggg ctaccaccca ccctctcagt cttgtgaaga gtctgggacc   7284

tccttcttcc ccacttctct cttccctcat tcctttctct ctccttctgg cctctcattt   7344

ccttacactc tgacatgaat gaattattat tatttttctt tttctttttt tttttacatt   7404

ttgtatagaa acaaattcat ttaaacaaac ttattattat tattttttac aaaatatata   7464

tatggagatg ctccctcccc ctgtgaaccc cccagtgccc ccgtggggct gagtctgtgg   7524

gcccattcgg ccaagctgga ttctgtgtac ctagtacaca ggcatgactg ggatcccgtg   7584

taccgagtac acgacccagg tatgtaccaa gtaggcaccc ttgggcgcac ccactggggc   7644

caggggtcgg gggagtgttg ggagcctcct ccccacccca cctccctcac ttcactgcat   7704

tccagattgg acatgttcca tagccttgct ggggaagggc ccactgccaa ctccctctgc   7764

cccagcccca cccttggcca tctccctttg ggaactaggg ggctgctggt gggaaatggg   7824

agccagggca gatgtatgca ttcctttatg tccctgtaaa tgtgggacta caagaagagg   7884

agctgcctga gtggtacttt ctcttcctgg taatcctctg gcccagcctt atggcagaat   7944

agaggtattt ttaggctatt tttgtaatat ggcttctggt caaaatccct gtgtagctga   8004

attcccaagc cctgcattgt acagcccccc actcccctca ccacctaata aaggaatagt   8064

taacactcaa aaaaaaaaaa aaaaaaa                                       8091


<210>  2
<211>  2321
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Pro Gly Ala Arg Gly Arg Arg Arg Arg Arg Arg Pro Met Ser 
1               5                   10                  15      


Pro Pro Pro Pro Pro Pro Pro Val Arg Ala Leu Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Gly Pro Gly Ala Ala Ala Pro Pro Cys Leu Asp Gly Ser Pro 
        35                  40                  45              


Cys Ala Asn Gly Gly Arg Cys Thr Gln Leu Pro Ser Arg Glu Ala Ala 
    50                  55                  60                  


Cys Leu Cys Pro Pro Gly Trp Val Gly Glu Arg Cys Gln Leu Glu Asp 
65                  70                  75                  80  


Pro Cys His Ser Gly Pro Cys Ala Gly Arg Gly Val Cys Gln Ser Ser 
                85                  90                  95      


Val Val Ala Gly Thr Ala Arg Phe Ser Cys Arg Cys Pro Arg Gly Phe 
            100                 105                 110         


Arg Gly Pro Asp Cys Ser Leu Pro Asp Pro Cys Leu Ser Ser Pro Cys 
        115                 120                 125             


Ala His Gly Ala Arg Cys Ser Val Gly Pro Asp Gly Arg Phe Leu Cys 
    130                 135                 140                 


Ser Cys Pro Pro Gly Tyr Gln Gly Arg Ser Cys Arg Ser Asp Val Asp 
145                 150                 155                 160 


Glu Cys Arg Val Gly Glu Pro Cys Arg His Gly Gly Thr Cys Leu Asn 
                165                 170                 175     


Thr Pro Gly Ser Phe Arg Cys Gln Cys Pro Ala Gly Tyr Thr Gly Pro 
            180                 185                 190         


Leu Cys Glu Asn Pro Ala Val Pro Cys Ala Pro Ser Pro Cys Arg Asn 
        195                 200                 205             


Gly Gly Thr Cys Arg Gln Ser Gly Asp Leu Thr Tyr Asp Cys Ala Cys 
    210                 215                 220                 


Leu Pro Gly Phe Glu Gly Gln Asn Cys Glu Val Asn Val Asp Asp Cys 
225                 230                 235                 240 


Pro Gly His Arg Cys Leu Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
                245                 250                 255     


Thr Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Phe Cys Thr 
            260                 265                 270         


Glu Asp Val Asp Glu Cys Gln Leu Gln Pro Asn Ala Cys His Asn Gly 
        275                 280                 285             


Gly Thr Cys Phe Asn Thr Leu Gly Gly His Ser Cys Val Cys Val Asn 
    290                 295                 300                 


Gly Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile Asp Asp Cys Ala Thr 
305                 310                 315                 320 


Ala Val Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe 
                325                 330                 335     


Tyr Cys Ala Cys Pro Met Gly Lys Thr Gly Leu Leu Cys His Leu Asp 
            340                 345                 350         


Asp Ala Cys Val Ser Asn Pro Cys His Glu Asp Ala Ile Cys Asp Thr 
        355                 360                 365             


Asn Pro Val Asn Gly Arg Ala Ile Cys Thr Cys Pro Pro Gly Phe Thr 
    370                 375                 380                 


Gly Gly Ala Cys Asp Gln Asp Val Asp Glu Cys Ser Ile Gly Ala Asn 
385                 390                 395                 400 


Pro Cys Glu His Leu Gly Arg Cys Val Asn Thr Gln Gly Ser Phe Leu 
                405                 410                 415     


Cys Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg Cys Glu Thr Asp Val 
            420                 425                 430         


Asn Glu Cys Leu Ser Gly Pro Cys Arg Asn Gln Ala Thr Cys Leu Asp 
        435                 440                 445             


Arg Ile Gly Gln Phe Thr Cys Ile Cys Met Ala Gly Phe Thr Gly Thr 
    450                 455                 460                 


Tyr Cys Glu Val Asp Ile Asp Glu Cys Gln Ser Ser Pro Cys Val Asn 
465                 470                 475                 480 


Gly Gly Val Cys Lys Asp Arg Val Asn Gly Phe Ser Cys Thr Cys Pro 
                485                 490                 495     


Ser Gly Phe Ser Gly Ser Thr Cys Gln Leu Asp Val Asp Glu Cys Ala 
            500                 505                 510         


Ser Thr Pro Cys Arg Asn Gly Ala Lys Cys Val Asp Gln Pro Asp Gly 
        515                 520                 525             


Tyr Glu Cys Arg Cys Ala Glu Gly Phe Glu Gly Thr Leu Cys Asp Arg 
    530                 535                 540                 


Asn Val Asp Asp Cys Ser Pro Asp Pro Cys His His Gly Arg Cys Val 
545                 550                 555                 560 


Asp Gly Ile Ala Ser Phe Ser Cys Ala Cys Ala Pro Gly Tyr Thr Gly 
                565                 570                 575     


Thr Arg Cys Glu Ser Gln Val Asp Glu Cys Arg Ser Gln Pro Cys Arg 
            580                 585                 590         


His Gly Gly Lys Cys Leu Asp Leu Val Asp Lys Tyr Leu Cys Arg Cys 
        595                 600                 605             


Pro Ser Gly Thr Thr Gly Val Asn Cys Glu Val Asn Ile Asp Asp Cys 
    610                 615                 620                 


Ala Ser Asn Pro Cys Thr Phe Gly Val Cys Arg Asp Gly Ile Asn Arg 
625                 630                 635                 640 


Tyr Asp Cys Val Cys Gln Pro Gly Phe Thr Gly Pro Leu Cys Asn Val 
                645                 650                 655     


Glu Ile Asn Glu Cys Ala Ser Ser Pro Cys Gly Glu Gly Gly Ser Cys 
            660                 665                 670         


Val Asp Gly Glu Asn Gly Phe Arg Cys Leu Cys Pro Pro Gly Ser Leu 
        675                 680                 685             


Pro Pro Leu Cys Leu Pro Pro Ser His Pro Cys Ala His Glu Pro Cys 
    690                 695                 700                 


Ser His Gly Ile Cys Tyr Asp Ala Pro Gly Gly Phe Arg Cys Val Cys 
705                 710                 715                 720 


Glu Pro Gly Trp Ser Gly Pro Arg Cys Ser Gln Ser Leu Ala Arg Asp 
                725                 730                 735     


Ala Cys Glu Ser Gln Pro Cys Arg Ala Gly Gly Thr Cys Ser Ser Asp 
            740                 745                 750         


Gly Met Gly Phe His Cys Thr Cys Pro Pro Gly Val Gln Gly Arg Gln 
        755                 760                 765             


Cys Glu Leu Leu Ser Pro Cys Thr Pro Asn Pro Cys Glu His Gly Gly 
    770                 775                 780                 


Arg Cys Glu Ser Ala Pro Gly Gln Leu Pro Val Cys Ser Cys Pro Gln 
785                 790                 795                 800 


Gly Trp Gln Gly Pro Arg Cys Gln Gln Asp Val Asp Glu Cys Ala Gly 
                805                 810                 815     


Pro Ala Pro Cys Gly Pro His Gly Ile Cys Thr Asn Leu Ala Gly Ser 
            820                 825                 830         


Phe Ser Cys Thr Cys His Gly Gly Tyr Thr Gly Pro Ser Cys Asp Gln 
        835                 840                 845             


Asp Ile Asn Asp Cys Asp Pro Asn Pro Cys Leu Asn Gly Gly Ser Cys 
    850                 855                 860                 


Gln Asp Gly Val Gly Ser Phe Ser Cys Ser Cys Leu Pro Gly Phe Ala 
865                 870                 875                 880 


Gly Pro Arg Cys Ala Arg Asp Val Asp Glu Cys Leu Ser Asn Pro Cys 
                885                 890                 895     


Gly Pro Gly Thr Cys Thr Asp His Val Ala Ser Phe Thr Cys Thr Cys 
            900                 905                 910         


Pro Pro Gly Tyr Gly Gly Phe His Cys Glu Gln Asp Leu Pro Asp Cys 
        915                 920                 925             


Ser Pro Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
    930                 935                 940                 


Ser Phe Ser Cys Leu Cys Arg Pro Gly Tyr Thr Gly Ala His Cys Gln 
945                 950                 955                 960 


His Glu Ala Asp Pro Cys Leu Ser Arg Pro Cys Leu His Gly Gly Val 
                965                 970                 975     


Cys Ser Ala Ala His Pro Gly Phe Arg Cys Thr Cys Leu Glu Ser Phe 
            980                 985                 990         


Thr Gly Pro Gln Cys Gln Thr Leu  Val Asp Trp Cys Ser  Arg Gln Pro 
        995                 1000                 1005             


Cys Gln  Asn Gly Gly Arg Cys  Val Gln Thr Gly Ala  Tyr Cys Leu 
    1010                 1015                 1020             


Cys Pro  Pro Gly Trp Ser Gly  Arg Leu Cys Asp Ile  Arg Ser Leu 
    1025                 1030                 1035             


Pro Cys  Arg Glu Ala Ala Ala  Gln Ile Gly Val Arg  Leu Glu Gln 
    1040                 1045                 1050             


Leu Cys  Gln Ala Gly Gly Gln  Cys Val Asp Glu Asp  Ser Ser His 
    1055                 1060                 1065             


Tyr Cys  Val Cys Pro Glu Gly  Arg Thr Gly Ser His  Cys Glu Gln 
    1070                 1075                 1080             


Glu Val  Asp Pro Cys Leu Ala  Gln Pro Cys Gln His  Gly Gly Thr 
    1085                 1090                 1095             


Cys Arg  Gly Tyr Met Gly Gly  Tyr Met Cys Glu Cys  Leu Pro Gly 
    1100                 1105                 1110             


Tyr Asn  Gly Asp Asn Cys Glu  Asp Asp Val Asp Glu  Cys Ala Ser 
    1115                 1120                 1125             


Gln Pro  Cys Gln His Gly Gly  Ser Cys Ile Asp Leu  Val Ala Arg 
    1130                 1135                 1140             


Tyr Leu  Cys Ser Cys Pro Pro  Gly Thr Leu Gly Val  Leu Cys Glu 
    1145                 1150                 1155             


Ile Asn  Glu Asp Asp Cys Gly  Pro Gly Pro Pro Leu  Asp Ser Gly 
    1160                 1165                 1170             


Pro Arg  Cys Leu His Asn Gly  Thr Cys Val Asp Leu  Val Gly Gly 
    1175                 1180                 1185             


Phe Arg  Cys Thr Cys Pro Pro  Gly Tyr Thr Gly Leu  Arg Cys Glu 
    1190                 1195                 1200             


Ala Asp  Ile Asn Glu Cys Arg  Ser Gly Ala Cys His  Ala Ala His 
    1205                 1210                 1215             


Thr Arg  Asp Cys Leu Gln Asp  Pro Gly Gly Gly Phe  Arg Cys Leu 
    1220                 1225                 1230             


Cys His  Ala Gly Phe Ser Gly  Pro Arg Cys Gln Thr  Val Leu Ser 
    1235                 1240                 1245             


Pro Cys  Glu Ser Gln Pro Cys  Gln His Gly Gly Gln  Cys Arg Pro 
    1250                 1255                 1260             


Ser Pro  Gly Pro Gly Gly Gly  Leu Thr Phe Thr Cys  His Cys Ala 
    1265                 1270                 1275             


Gln Pro  Phe Trp Gly Pro Arg  Cys Glu Arg Val Ala  Arg Ser Cys 
    1280                 1285                 1290             


Arg Glu  Leu Gln Cys Pro Val  Gly Val Pro Cys Gln  Gln Thr Pro 
    1295                 1300                 1305             


Arg Gly  Pro Arg Cys Ala Cys  Pro Pro Gly Leu Ser  Gly Pro Ser 
    1310                 1315                 1320             


Cys Arg  Ser Phe Pro Gly Ser  Pro Pro Gly Ala Ser  Asn Ala Ser 
    1325                 1330                 1335             


Cys Ala  Ala Ala Pro Cys Leu  His Gly Gly Ser Cys  Arg Pro Ala 
    1340                 1345                 1350             


Pro Leu  Ala Pro Phe Phe Arg  Cys Ala Cys Ala Gln  Gly Trp Thr 
    1355                 1360                 1365             


Gly Pro  Arg Cys Glu Ala Pro  Ala Ala Ala Pro Glu  Val Ser Glu 
    1370                 1375                 1380             


Glu Pro  Arg Cys Pro Arg Ala  Ala Cys Gln Ala Lys  Arg Gly Asp 
    1385                 1390                 1395             


Gln Arg  Cys Asp Arg Glu Cys  Asn Ser Pro Gly Cys  Gly Trp Asp 
    1400                 1405                 1410             


Gly Gly  Asp Cys Ser Leu Ser  Val Gly Asp Pro Trp  Arg Gln Cys 
    1415                 1420                 1425             


Glu Ala  Leu Gln Cys Trp Arg  Leu Phe Asn Asn Ser  Arg Cys Asp 
    1430                 1435                 1440             


Pro Ala  Cys Ser Ser Pro Ala  Cys Leu Tyr Asp Asn  Phe Asp Cys 
    1445                 1450                 1455             


His Ala  Gly Gly Arg Glu Arg  Thr Cys Asn Pro Val  Tyr Glu Lys 
    1460                 1465                 1470             


Tyr Cys  Ala Asp His Phe Ala  Asp Gly Arg Cys Asp  Gln Gly Cys 
    1475                 1480                 1485             


Asn Thr  Glu Glu Cys Gly Trp  Asp Gly Leu Asp Cys  Ala Ser Glu 
    1490                 1495                 1500             


Val Pro  Ala Leu Leu Ala Arg  Gly Val Leu Val Leu  Thr Val Leu 
    1505                 1510                 1515             


Leu Pro  Pro Glu Glu Leu Leu  Arg Ser Ser Ala Asp  Phe Leu Gln 
    1520                 1525                 1530             


Arg Leu  Ser Ala Ile Leu Arg  Thr Ser Leu Arg Phe  Arg Leu Asp 
    1535                 1540                 1545             


Ala His  Gly Gln Ala Met Val  Phe Pro Tyr His Arg  Pro Ser Pro 
    1550                 1555                 1560             


Gly Ser  Glu Pro Arg Ala Arg  Arg Glu Leu Ala Pro  Glu Val Ile 
    1565                 1570                 1575             


Gly Ser  Val Val Met Leu Glu  Ile Asp Asn Arg Leu  Cys Leu Gln 
    1580                 1585                 1590             


Ser Pro  Glu Asn Asp His Cys  Phe Pro Asp Ala Gln  Ser Ala Ala 
    1595                 1600                 1605             


Asp Tyr  Leu Gly Ala Leu Ser  Ala Val Glu Arg Leu  Asp Phe Pro 
    1610                 1615                 1620             


Tyr Pro  Leu Arg Asp Val Arg  Gly Glu Pro Leu Glu  Pro Pro Glu 
    1625                 1630                 1635             


Pro Ser  Val Pro Leu Leu Pro  Leu Leu Val Ala Gly  Ala Val Leu 
    1640                 1645                 1650             


Leu Leu  Val Ile Leu Val Leu  Gly Val Met Val Ala  Arg Arg Lys 
    1655                 1660                 1665             


Arg Glu  His Ser Thr Leu Trp  Phe Pro Glu Gly Phe  Ser Leu His 
    1670                 1675                 1680             


Lys Asp  Val Ala Ser Gly His  Lys Gly Arg Arg Glu  Pro Val Gly 
    1685                 1690                 1695             


Gln Asp  Ala Leu Gly Met Lys  Asn Met Ala Lys Gly  Glu Ser Leu 
    1700                 1705                 1710             


Met Gly  Glu Val Ala Thr Asp  Trp Met Asp Thr Glu  Cys Pro Glu 
    1715                 1720                 1725             


Ala Lys  Arg Leu Lys Val Glu  Glu Pro Gly Met Gly  Ala Glu Glu 
    1730                 1735                 1740             


Ala Val  Asp Cys Arg Gln Trp  Thr Gln His His Leu  Val Ala Ala 
    1745                 1750                 1755             


Asp Ile  Arg Val Ala Pro Ala  Met Ala Leu Thr Pro  Pro Gln Gly 
    1760                 1765                 1770             


Asp Ala  Asp Ala Asp Gly Met  Asp Val Asn Val Arg  Gly Pro Asp 
    1775                 1780                 1785             


Gly Phe  Thr Pro Leu Met Leu  Ala Ser Phe Cys Gly  Gly Ala Leu 
    1790                 1795                 1800             


Glu Pro  Met Pro Thr Glu Glu  Asp Glu Ala Asp Asp  Thr Ser Ala 
    1805                 1810                 1815             


Ser Ile  Ile Ser Asp Leu Ile  Cys Gln Gly Ala Gln  Leu Gly Ala 
    1820                 1825                 1830             


Arg Thr  Asp Arg Thr Gly Glu  Thr Ala Leu His Leu  Ala Ala Arg 
    1835                 1840                 1845             


Tyr Ala  Arg Ala Asp Ala Ala  Lys Arg Leu Leu Asp  Ala Gly Ala 
    1850                 1855                 1860             


Asp Thr  Asn Ala Gln Asp His  Ser Gly Arg Thr Pro  Leu His Thr 
    1865                 1870                 1875             


Ala Val  Thr Ala Asp Ala Gln  Gly Val Phe Gln Ile  Leu Ile Arg 
    1880                 1885                 1890             


Asn Arg  Ser Thr Asp Leu Asp  Ala Arg Met Ala Asp  Gly Ser Thr 
    1895                 1900                 1905             


Ala Leu  Ile Leu Ala Ala Arg  Leu Ala Val Glu Gly  Met Val Glu 
    1910                 1915                 1920             


Glu Leu  Ile Ala Ser His Ala  Asp Val Asn Ala Val  Asp Glu Leu 
    1925                 1930                 1935             


Gly Lys  Ser Ala Leu His Trp  Ala Ala Ala Val Asn  Asn Val Glu 
    1940                 1945                 1950             


Ala Thr  Leu Ala Leu Leu Lys  Asn Gly Ala Asn Lys  Asp Met Gln 
    1955                 1960                 1965             


Asp Ser  Lys Glu Glu Thr Pro  Leu Phe Leu Ala Ala  Arg Glu Gly 
    1970                 1975                 1980             


Ser Tyr  Glu Ala Ala Lys Leu  Leu Leu Asp His Phe  Ala Asn Arg 
    1985                 1990                 1995             


Glu Ile  Thr Asp His Leu Asp  Arg Leu Pro Arg Asp  Val Ala Gln 
    2000                 2005                 2010             


Glu Arg  Leu His Gln Asp Ile  Val Arg Leu Leu Asp  Gln Pro Ser 
    2015                 2020                 2025             


Gly Pro  Arg Ser Pro Pro Gly  Pro His Gly Leu Gly  Pro Leu Leu 
    2030                 2035                 2040             


Cys Pro  Pro Gly Ala Phe Leu  Pro Gly Leu Lys Ala  Ala Gln Ser 
    2045                 2050                 2055             


Gly Ser  Lys Lys Ser Arg Arg  Pro Pro Gly Lys Ala  Gly Leu Gly 
    2060                 2065                 2070             


Pro Gln  Gly Pro Arg Gly Arg  Gly Lys Lys Leu Thr  Leu Ala Cys 
    2075                 2080                 2085             


Pro Gly  Pro Leu Ala Asp Ser  Ser Val Thr Leu Ser  Pro Val Asp 
    2090                 2095                 2100             


Ser Leu  Asp Ser Pro Arg Pro  Phe Gly Gly Pro Pro  Ala Ser Pro 
    2105                 2110                 2115             


Gly Gly  Phe Pro Leu Glu Gly  Pro Tyr Ala Ala Ala  Thr Ala Thr 
    2120                 2125                 2130             


Ala Val  Ser Leu Ala Gln Leu  Gly Gly Pro Gly Arg  Ala Gly Leu 
    2135                 2140                 2145             


Gly Arg  Gln Pro Pro Gly Gly  Cys Val Leu Ser Leu  Gly Leu Leu 
    2150                 2155                 2160             


Asn Pro  Val Ala Val Pro Leu  Asp Trp Ala Arg Leu  Pro Pro Pro 
    2165                 2170                 2175             


Ala Pro  Pro Gly Pro Ser Phe  Leu Leu Pro Leu Ala  Pro Gly Pro 
    2180                 2185                 2190             


Gln Leu  Leu Asn Pro Gly Thr  Pro Val Ser Pro Gln  Glu Arg Pro 
    2195                 2200                 2205             


Pro Pro  Tyr Leu Ala Val Pro  Gly His Gly Glu Glu  Tyr Pro Val 
    2210                 2215                 2220             


Ala Gly  Ala His Ser Ser Pro  Pro Lys Ala Arg Phe  Leu Arg Val 
    2225                 2230                 2235             


Pro Ser  Glu His Pro Tyr Leu  Thr Pro Ser Pro Glu  Ser Pro Glu 
    2240                 2245                 2250             


His Trp  Ala Ser Pro Ser Pro  Pro Ser Leu Ser Asp  Trp Ser Glu 
    2255                 2260                 2265             


Ser Thr  Pro Ser Pro Ala Thr  Ala Thr Gly Ala Met  Ala Thr Thr 
    2270                 2275                 2280             


Thr Gly  Ala Leu Pro Ala Gln  Pro Leu Pro Leu Ser  Val Pro Ser 
    2285                 2290                 2295             


Ser Leu  Ala Gln Ala Gln Thr  Gln Leu Gly Pro Gln  Pro Glu Val 
    2300                 2305                 2310             


Thr Pro  Lys Arg Gln Val Leu  Ala 
    2315                 2320     


<210>  3
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  3

Cys Phe Asn Thr Leu Gly Gly His Ser 
1               5                   


<210>  4
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  4

Cys Val Cys Val Asn Gly Trp Thr Gly Glu Ser 
1               5                   10      


<210>  5
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  5

Cys Ala Thr Ala Val 
1               5   


<210>  6
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  6

Cys Phe His Gly Ala Thr 
1               5       


<210>  7
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  7

Cys Val Ser Asn Pro 
1               5   


<210>  8
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  8

Cys Leu Asn Gly Gly Ser 
1               5       


<210>  9
<211>  38
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  9

Cys Phe Asn Thr Leu Gly Gly His Ser Cys Val Cys Val Asn Gly Trp 
1               5                   10                  15      


Thr Gly Glu Ser Cys Ser Gln Asn Ile Asp Asp Cys Ala Thr Ala Val 
            20                  25                  30          


Cys Phe His Gly Ala Thr 
        35              


<210>  10
<211>  38
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  10

Cys Thr Asn Leu Ala Gly Ser Phe Ser Cys Thr Cys His Gly Gly Tyr 
1               5                   10                  15      


Thr Gly Pro Ser Cys Asp Gln Asp Ile Asn Asp Cys Asp Pro Asn Pro 
            20                  25                  30          


Cys Leu Asn Gly Gly Ser 
        35              


