                         SEQUENCE LISTING

<110>  University of Tennessee Research Foundation
       Divi, Murali K.
       Wood, George C.
       Gaber, M. Waleed
       Thoma, Laura
 
<120>  METHODS AND COMPOSITIONS FOR INHIBITING UNDESIRABLE CELLULAR 
       PROLIFERATION BY TARGETED LIPOSOME DELIVERY OF ACTIVE AGENTS

<130>  1306-34 PCT

<150>  US 60/994,463
<151>  2007-09-19

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  695
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Leu Ala Val Gly Ala Leu Leu Val Cys Ala Val Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Val Pro Asp Lys Thr Val Arg Trp Cys Ala Val Ser Glu 
            20                  25                  30          


His Glu Ala Thr Lys Cys Gln Ser Phe Arg Asp His Met Lys Ser Val 
        35                  40                  45              


Ile Pro Ser Asp Gly Pro Ser Val Ala Cys Val Lys Lys Ala Ser Tyr 
    50                  55                  60                  


Leu Asp Cys Ile Arg Ala Ile Ala Ala Asn Glu Ala Asp Ala Val Thr 
65                  70                  75                  80  


Leu Asp Ala Gly Leu Val Tyr Asp Ala Tyr Leu Ala Pro Asn Asn Leu 
                85                  90                  95      


Lys Pro Val Val Ala Glu Phe Tyr Gly Ser Lys Glu Asp Pro Gln Thr 
            100                 105                 110         


Phe Tyr Tyr Ala Val Ala Val Val Lys Lys Asp Ser Gly Phe Gln Met 
        115                 120                 125             


Asn Gln Leu Arg Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser 
    130                 135                 140                 


Ala Gly Trp Asn Ile Pro Ile Gly Leu Leu Tyr Cys Asp Leu Pro Glu 
145                 150                 155                 160 


Pro Arg Lys Pro Leu Glu Lys Ala Val Ala Asn Phe Phe Ser Gly Ser 
                165                 170                 175     


Cys Ala Pro Cys Ala Asp Gly Thr Asp Phe Pro Gln Leu Cys Gln Leu 
            180                 185                 190         


Cys Pro Gly Cys Gly Cys Ser Thr Leu Asn Gln Tyr Phe Gly Tyr Ser 
        195                 200                 205             


Gly Ala Phe Lys Cys Leu Lys Asp Gly Ala Gly Asp Val Ala Phe Val 
    210                 215                 220                 


Lys His Ser Thr Ile Phe Glu Asn Leu Ala Asn Lys Ala Asp Arg Asp 
225                 230                 235                 240 


Gln Tyr Glu Leu Leu Cys Leu Asp Asn Thr Arg Lys Pro Val Asp Glu 
                245                 250                 255     


Tyr Lys Asp Cys His Leu Ala Gln Val Pro Ser His Thr Val Val Ala 
            260                 265                 270         


Arg Ser Met Gly Gly Lys Glu Asp Leu Ile Trp Glu Leu Leu Asn Gln 
        275                 280                 285             


Ala Gln Glu His Phe Gly Lys Asp Lys Ser Lys Glu Phe Gln Leu Phe 
    290                 295                 300                 


Ser Ser Pro His Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala His Gly 
305                 310                 315                 320 


Phe Leu Lys Val Pro Pro Arg Met Asp Ala Lys Met Tyr Leu Gly Tyr 
                325                 330                 335     


Glu Tyr Val Thr Ala Ile Arg Asn Leu Arg Glu Gly Thr Cys Pro Glu 
            340                 345                 350         


Ala Pro Thr Asp Glu Cys Lys Pro Val Lys Trp Cys Ala Leu Ser His 
        355                 360                 365             


His Glu Arg Leu Lys Cys Asp Glu Trp Ser Val Asn Ser Val Gly Lys 
    370                 375                 380                 


Ile Glu Cys Val Ser Ala Glu Thr Thr Glu Asp Cys Ile Ala Lys Ile 
385                 390                 395                 400 


Met Asn Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Phe Val Tyr 
                405                 410                 415     


Ile Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Asn 
            420                 425                 430         


Lys Ser Asp Asn Cys Glu Asp Thr Pro Glu Ala Gly Tyr Phe Ala Val 
        435                 440                 445             


Ala Val Val Lys Lys Ser Ala Ser Asp Leu Thr Trp Asp Asn Leu Lys 
    450                 455                 460                 


Gly Lys Lys Ser Cys His Thr Ala Val Gly Arg Thr Ala Gly Trp Asn 
465                 470                 475                 480 


Ile Pro Met Gly Leu Leu Tyr Asn Lys Ile Asn His Cys Arg Phe Asp 
                485                 490                 495     


Glu Phe Phe Ser Glu Gly Cys Ala Pro Gly Ser Lys Lys Asp Ser Ser 
            500                 505                 510         


Leu Cys Lys Leu Cys Met Gly Ser Leu Cys Glu Pro Asn Asn Lys Glu 
        515                 520                 525             


Gly Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Val Glu Lys Gly 
    530                 535                 540                 


Asp Val Ala Phe Val Lys His Gln Thr Val Pro Gln Asn Thr Gly Gly 
545                 550                 555                 560 


Lys Asn Pro Asp Pro Trp Ala Lys Asn Leu Asn Glu Lys Asp Tyr Glu 
                565                 570                 575     


Leu Leu Cys Leu Asp Gly Thr Arg Lys Pro Val Glu Glu Tyr Ala Asn 
            580                 585                 590         


Cys His Leu Ala Arg Ala Pro Asn His Ala Val Val Thr Arg Lys Asp 
        595                 600                 605             


Lys Glu Ala Cys Val His Lys Ile Leu Arg Gln Gln Gln His Leu Phe 
    610                 615                 620                 


Gly Ser Asn Val Thr Asp Cys Ser Gly Asn Phe Cys Leu Phe Arg Ser 
625                 630                 635                 640 


Glu Thr Lys Asp Leu Leu Phe Arg Asp Asp Thr Val Cys Leu Ala Lys 
                645                 650                 655     


Leu His Asp Arg Asn Thr Tyr Glu Lys Tyr Leu Gly Glu Glu Tyr Val 
            660                 665                 670         


Lys Ala Val Gly Asn Leu Arg Lys Cys Ser Thr Ser Ser Leu Leu Glu 
        675                 680                 685             


Ala Cys Thr Phe Arg Arg Pro 
    690                 695 


<210>  2
<211>  697
<212>  PRT
<213>  Mus musculus

<400>  2

Met Arg Leu Thr Val Gly Ala Leu Leu Ala Cys Ala Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Val Pro Asp Lys Thr Val Lys Trp Cys Ala Val Ser Glu 
            20                  25                  30          


His Glu Asn Thr Lys Cys Ile Ser Phe Arg Asp His Met Lys Thr Val 
        35                  40                  45              


Leu Pro Pro Asp Gly Pro Arg Leu Ala Cys Val Lys Lys Thr Ser Tyr 
    50                  55                  60                  


Pro Asp Cys Ile Lys Ala Ile Ser Ala Ser Glu Ala Asp Ala Met Thr 
65                  70                  75                  80  


Leu Asp Gly Gly Trp Val Tyr Asp Ala Gly Leu Thr Pro Asn Asn Leu 
                85                  90                  95      


Lys Pro Val Ala Ala Glu Phe Tyr Gly Ser Val Glu His Pro Gln Thr 
            100                 105                 110         


Tyr Tyr Tyr Ala Val Ala Val Val Lys Lys Gly Thr Asp Phe Gln Leu 
        115                 120                 125             


Asn Gln Leu Glu Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser 
    130                 135                 140                 


Ala Gly Trp Val Ile Pro Ile Gly Leu Leu Phe Cys Lys Leu Ser Glu 
145                 150                 155                 160 


Pro Arg Ser Pro Leu Glu Lys Ala Val Ser Ser Phe Phe Ser Gly Ser 
                165                 170                 175     


Cys Val Pro Cys Ala Asp Pro Val Ala Phe Pro Lys Leu Cys Gln Leu 
            180                 185                 190         


Cys Pro Gly Cys Gly Cys Ser Ser Thr Gln Pro Phe Phe Gly Tyr Val 
        195                 200                 205             


Gly Ala Phe Lys Cys Leu Lys Asp Gly Gly Gly Asp Val Ala Phe Val 
    210                 215                 220                 


Lys His Thr Thr Ile Phe Glu Val Leu Pro Glu Lys Ala Asp Arg Asp 
225                 230                 235                 240 


Gln Tyr Glu Leu Leu Cys Leu Asp Asn Thr Arg Lys Pro Val Asp Gln 
                245                 250                 255     


Tyr Glu Asp Cys Tyr Leu Ala Arg Ile Pro Ser His Ala Val Val Ala 
            260                 265                 270         


Arg Lys Asn Asn Gly Lys Glu Asp Leu Ile Trp Glu Ile Leu Lys Val 
        275                 280                 285             


Ala Gln Glu His Phe Gly Lys Gly Lys Ser Lys Asp Phe Gln Leu Phe 
    290                 295                 300                 


Ser Ser Pro Leu Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala Phe Gly 
305                 310                 315                 320 


Leu Leu Arg Val Pro Pro Arg Met Asp Tyr Arg Leu Tyr Leu Gly His 
                325                 330                 335     


Asn Tyr Val Thr Ala Ile Arg Asn Gln Gln Glu Gly Val Cys Pro Glu 
            340                 345                 350         


Gly Ser Ile Asp Asn Ser Pro Val Lys Trp Cys Ala Leu Ser His Leu 
        355                 360                 365             


Glu Arg Thr Lys Cys Asp Glu Trp Ser Ile Ile Ser Glu Gly Lys Ile 
    370                 375                 380                 


Glu Cys Glu Ser Ala Glu Thr Thr Glu Asp Cys Ile Glu Lys Ile Val 
385                 390                 395                 400 


Asn Gly Glu Ala Asp Ala Met Thr Leu Asp Gly Gly His Ala Tyr Ile 
                405                 410                 415     


Ala Gly Gln Cys Gly Leu Val Pro Val Met Ala Glu Tyr Tyr Glu Ser 
            420                 425                 430         


Ser Asn Cys Ala Ile Pro Ser Gln Gln Gly Ile Phe Pro Lys Gly Tyr 
        435                 440                 445             


Tyr Ala Val Ala Val Val Lys Ala Ser Asp Thr Ser Ile Thr Trp Asn 
    450                 455                 460                 


Asn Leu Lys Gly Lys Lys Ser Cys His Thr Gly Val Asp Arg Thr Ala 
465                 470                 475                 480 


Gly Trp Asn Ile Pro Met Gly Met Leu Tyr Asn Arg Ile Asn His Cys 
                485                 490                 495     


Lys Phe Asp Glu Phe Phe Ser Gln Gly Cys Ala Pro Gly Tyr Glu Lys 
            500                 505                 510         


Asn Ser Thr Leu Cys Asp Leu Cys Ile Gly Pro Leu Lys Cys Ala Pro 
        515                 520                 525             


Asn Asn Lys Glu Glu Tyr Asn Gly Tyr Thr Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Lys Gly Asp Val Ala Phe Val Lys His Gln Thr Val Leu Asp 
545                 550                 555                 560 


Asn Thr Glu Gly Lys Asn Pro Ala Glu Trp Ala Lys Asn Leu Lys Gln 
                565                 570                 575     


Glu Asp Phe Glu Leu Leu Cys Pro Asp Gly Thr Arg Lys Pro Val Lys 
            580                 585                 590         


Asp Phe Ala Ser Cys His Leu Ala Gln Ala Pro Asn His Val Val Val 
        595                 600                 605             


Ser Arg Lys Glu Lys Ala Ala Arg Val Lys Ala Val Leu Thr Ser Gln 
    610                 615                 620                 


Glu Thr Leu Phe Gly Gly Ser Asp Cys Thr Gly Asn Phe Cys Leu Phe 
625                 630                 635                 640 


Lys Ser Thr Thr Lys Asp Leu Leu Phe Arg Asp Asp Thr Lys Cys Phe 
                645                 650                 655     


Val Lys Leu Pro Glu Gly Thr Thr Pro Glu Lys Tyr Leu Gly Ala Glu 
            660                 665                 670         


Tyr Met Gln Ser Val Gly Asn Met Arg Lys Cys Ser Thr Ser Arg Leu 
        675                 680                 685             


Leu Glu Ala Cys Thr Phe His Lys His 
    690                 695         


<210>  3
<211>  698
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Met Arg Phe Ala Val Gly Ala Leu Leu Ala Cys Ala Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Val Pro Asp Lys Thr Val Lys Trp Cys Ala Val Ser Glu 
            20                  25                  30          


His Glu Asn Thr Lys Cys Ile Ser Phe Arg Asp His Met Lys Thr Val 
        35                  40                  45              


Leu Pro Ala Asp Gly Pro Arg Leu Ala Cys Val Lys Lys Thr Ser Tyr 
    50                  55                  60                  


Gln Asp Cys Ile Lys Ala Ile Ser Gly Gly Glu Ala Asp Ala Ile Thr 
65                  70                  75                  80  


Leu Asp Gly Gly Trp Val Tyr Asp Ala Gly Leu Thr Pro Asn Asn Leu 
                85                  90                  95      


Lys Pro Val Ala Ala Glu Phe Tyr Gly Ser Leu Glu His Pro Gln Thr 
            100                 105                 110         


His Tyr Leu Ala Val Ala Val Val Lys Lys Gly Thr Asp Phe Gln Leu 
        115                 120                 125             


Asn Gln Leu Gln Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser 
    130                 135                 140                 


Ala Gly Trp Ile Ile Pro Ile Gly Leu Leu Phe Cys Asn Leu Pro Glu 
145                 150                 155                 160 


Pro Arg Lys Pro Leu Glu Lys Ala Val Ala Ser Phe Phe Ser Gly Ser 
                165                 170                 175     


Cys Val Pro Cys Ala Asp Pro Val Ala Phe Pro Gln Leu Cys Gln Leu 
            180                 185                 190         


Cys Pro Gly Cys Gly Cys Ser Pro Thr Gln Pro Phe Phe Gly Tyr Val 
        195                 200                 205             


Gly Ala Phe Lys Cys Leu Arg Asp Gly Gly Gly Asp Val Ala Phe Val 
    210                 215                 220                 


Lys His Thr Thr Ile Phe Glu Val Leu Pro Gln Lys Ala Asp Arg Asp 
225                 230                 235                 240 


Gln Tyr Glu Leu Leu Cys Leu Asp Asn Thr Arg Lys Pro Val Asp Gln 
                245                 250                 255     


Tyr Glu Asp Cys Tyr Leu Ala Arg Ile Pro Ser His Ala Val Val Ala 
            260                 265                 270         


Arg Asn Gly Asp Gly Lys Glu Asp Leu Ile Trp Glu Ile Leu Lys Val 
        275                 280                 285             


Ala Gln Glu His Phe Gly Lys Gly Lys Ser Lys Asp Phe Gln Leu Phe 
    290                 295                 300                 


Gly Ser Pro Leu Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala Phe Gly 
305                 310                 315                 320 


Leu Leu Arg Val Pro Pro Arg Met Asp Tyr Arg Leu Tyr Leu Gly His 
                325                 330                 335     


Ser Tyr Val Thr Ala Ile Arg Asn Gln Arg Glu Gly Val Cys Pro Glu 
            340                 345                 350         


Gly Ser Ile Asp Ser Ala Pro Val Lys Trp Cys Ala Leu Ser His Gln 
        355                 360                 365             


Glu Arg Ala Lys Cys Asp Glu Trp Ser Val Ser Ser Asn Gly Gln Ile 
    370                 375                 380                 


Glu Cys Glu Ser Ala Glu Ser Thr Glu Asp Cys Ile Asp Lys Ile Val 
385                 390                 395                 400 


Asn Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly His Ala Tyr Ile 
                405                 410                 415     


Ala Gly Gln Cys Gly Leu Val Pro Val Met Ala Glu Asn Tyr Asp Ile 
            420                 425                 430         


Ser Ser Cys Thr Asn Pro Gln Ser Asp Val Phe Pro Lys Gly Tyr Tyr 
        435                 440                 445             


Ala Val Ala Val Val Lys Ala Ser Asp Ser Ser Ile Asn Trp Asn Asn 
    450                 455                 460                 


Leu Lys Gly Lys Lys Ser Cys His Thr Gly Val Asp Arg Thr Ala Gly 
465                 470                 475                 480 


Trp Asn Ile Pro Met Gly Leu Leu Phe Ser Arg Ile Asn His Cys Lys 
                485                 490                 495     


Phe Asp Glu Phe Phe Ser Gln Gly Cys Ala Pro Gly Tyr Lys Lys Asn 
            500                 505                 510         


Ser Thr Leu Cys Asp Leu Cys Ile Gly Pro Ala Lys Cys Ala Pro Asn 
        515                 520                 525             


Asn Arg Glu Gly Tyr Asn Gly Tyr Thr Gly Ala Phe Gln Cys Leu Val 
    530                 535                 540                 


Glu Lys Gly Asp Val Ala Phe Val Lys His Gln Thr Val Leu Glu Asn 
545                 550                 555                 560 


Thr Asn Gly Lys Asn Thr Ala Ala Trp Ala Lys Asp Leu Lys Gln Glu 
                565                 570                 575     


Asp Phe Gln Leu Leu Cys Pro Asp Gly Thr Lys Lys Pro Val Thr Glu 
            580                 585                 590         


Phe Ala Thr Cys His Leu Ala Gln Ala Pro Asn His Val Val Val Ser 
        595                 600                 605             


Arg Lys Glu Lys Ala Ala Arg Val Ser Thr Val Leu Thr Ala Gln Lys 
    610                 615                 620                 


Asp Leu Phe Trp Lys Gly Asp Lys Asp Cys Thr Gly Asn Phe Cys Leu 
625                 630                 635                 640 


Phe Arg Ser Ser Thr Lys Asp Leu Leu Phe Arg Asp Asp Thr Lys Cys 
                645                 650                 655     


Leu Thr Lys Leu Pro Glu Gly Thr Thr Tyr Glu Glu Tyr Leu Gly Ala 
            660                 665                 670         


Glu Tyr Leu Gln Ala Val Gly Asn Ile Arg Lys Cys Ser Thr Ser Arg 
        675                 680                 685             


Leu Leu Glu Ala Cys Thr Phe His Lys Ser 
    690                 695             


<210>  4
<211>  703
<212>  PRT
<213>  Equus caballus

<400>  4

Met Arg Leu Ala Ile Arg Ala Leu Leu Ala Cys Ala Val Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Glu Gln Thr Val Arg Trp Cys Thr Val Ser Asn His Glu 
            20                  25                  30          


Val Ser Lys Cys Ala Ser Phe Arg Asp Ser Met Lys Ser Ile Val Pro 
        35                  40                  45              


Ala Pro Pro Leu Val Ala Cys Val Lys Arg Thr Ser Tyr Leu Glu Cys 
    50                  55                  60                  


Ile Lys Ala Ile Ala Asp Asn Glu Ala Asp Ala Val Thr Leu Asp Ala 
65                  70                  75                  80  


Gly Leu Val Phe Glu Ala Gly Leu Ser Pro Tyr Asn Leu Lys Pro Val 
                85                  90                  95      


Val Ala Glu Phe Tyr Gly Ser Lys Thr Glu Pro Gln Thr His Tyr Tyr 
            100                 105                 110         


Ala Val Ala Val Val Lys Lys Asn Ser Asn Phe Gln Leu Asn Gln Leu 
        115                 120                 125             


Gln Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser Ala Gly Trp 
    130                 135                 140                 


Asn Ile Pro Ile Gly Leu Leu Tyr Trp Gln Leu Pro Glu Pro Arg Glu 
145                 150                 155                 160 


Ser Leu Gln Lys Ala Val Ser Asn Phe Phe Ala Gly Ser Cys Val Pro 
                165                 170                 175     


Cys Ala Asp Arg Thr Ala Val Pro Asn Leu Cys Gln Leu Cys Val Gly 
            180                 185                 190         


Lys Gly Thr Asp Lys Cys Ala Cys Ser Asn His Glu Pro Tyr Phe Gly 
        195                 200                 205             


Tyr Ser Gly Ala Phe Lys Cys Leu Ala Asp Gly Ala Gly Asp Val Ala 
    210                 215                 220                 


Phe Val Lys His Ser Thr Val Leu Glu Asn Leu Pro Gln Glu Ala Asp 
225                 230                 235                 240 


Arg Asp Glu Tyr Gln Leu Leu Cys Arg Asp Asn Thr Arg Lys Ser Val 
                245                 250                 255     


Asp Glu Tyr Lys Asp Cys Tyr Leu Ala Ser Ile Pro Ser His Ala Val 
            260                 265                 270         


Val Ala Arg Ser Val Asp Gly Lys Glu Asp Leu Ile Trp Gly Leu Leu 
        275                 280                 285             


Asn Gln Ala Gln Glu His Phe Gly Thr Glu Lys Ser Lys Asp Phe His 
    290                 295                 300                 


Leu Phe Ser Ser Pro His Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala 
305                 310                 315                 320 


Leu Gly Phe Leu Arg Ile Pro Pro Ala Met Asp Thr Trp Leu Tyr Leu 
                325                 330                 335     


Gly Tyr Glu Tyr Val Thr Ala Ile Arg Asn Leu Arg Glu Asp Ile Arg 
            340                 345                 350         


Pro Glu Val Pro Lys Asp Glu Cys Lys Lys Val Lys Trp Cys Ala Ile 
        355                 360                 365             


Gly His His Glu Lys Val Lys Cys Asp Glu Trp Ser Val Asn Ser Gly 
    370                 375                 380                 


Gly Asn Ile Glu Cys Glu Ser Ala Gln Ser Thr Glu Asp Cys Ile Ala 
385                 390                 395                 400 


Lys Ile Val Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Phe 
                405                 410                 415     


Ile Tyr Ile Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn 
            420                 425                 430         


Tyr Glu Thr Arg Ser Gly Ser Ala Cys Val Asp Thr Pro Glu Glu Gly 
        435                 440                 445             


Tyr His Ala Val Ala Val Val Lys Ser Ser Ser Asp Pro Asp Leu Thr 
    450                 455                 460                 


Trp Asn Ser Leu Lys Gly Lys Lys Ser Cys His Thr Gly Val Asp Arg 
465                 470                 475                 480 


Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Glu Ile Lys His Cys Glu 
                485                 490                 495     


Phe Asp Lys Phe Phe Arg Glu Gly Cys Ala Pro Gly Tyr Arg Arg Asn 
            500                 505                 510         


Ser Thr Leu Cys Asn Leu Cys Ile Gly Ser Ala Ser Gly Pro Gly Arg 
        515                 520                 525             


Glu Cys Glu Pro Asn Asn His Glu Arg Tyr Tyr Gly Tyr Thr Gly Ala 
    530                 535                 540                 


Phe Arg Cys Leu Val Glu Lys Gly Asp Val Ala Phe Val Lys His Gln 
545                 550                 555                 560 


Thr Val Glu Gln Asn Thr Asp Gly Arg Asn Pro Asp Asp Trp Ala Lys 
                565                 570                 575     


Asp Leu Lys Ser Glu Asn Phe Lys Leu Leu Cys Pro Asp Gly Thr Arg 
            580                 585                 590         


Lys Ser Val Thr Glu Phe Lys Ser Cys Tyr Leu Ala Arg Ala Pro Asn 
        595                 600                 605             


His Ala Val Val Ser Arg Lys Glu Lys Ala Ala Cys Val Cys Gln Glu 
    610                 615                 620                 


Leu His Asn Gln Gln Ala Ser Tyr Gly Lys Asn Gly Ser His Cys Pro 
625                 630                 635                 640 


Asp Lys Phe Cys Leu Phe Gln Ser Ala Thr Lys Asp Leu Leu Phe Arg 
                645                 650                 655     


Asp Asp Thr Gln Cys Leu Ala Asn Leu Gln Pro Thr Thr Thr Tyr Lys 
            660                 665                 670         


Thr Tyr Leu Gly Glu Lys Tyr Leu Thr Ala Val Ala Asn Leu Arg Gln 
        675                 680                 685             


Cys Ser Thr Ser Arg Leu Leu Glu Ala Cys Thr Phe His Arg Val 
    690                 695                 700             


<210>  5
<211>  695
<212>  PRT
<213>  Bos taurus

<400>  5

Met Arg Pro Ala Val Arg Ala Leu Leu Ala Cys Ala Val Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Asp Pro Glu Arg Thr Val Arg Trp Cys Thr Ile Ser Thr 
            20                  25                  30          


His Glu Ala Asn Lys Cys Ala Ser Phe Arg Glu Asn Val Leu Arg Ser 
        35                  40                  45              


Gly Pro Phe Val Ser Cys Val Lys Lys Thr Ser His Met Asp Cys Ile 
    50                  55                  60                  


Lys Ala Ile Ser Asn Asn Glu Ala Asp Ala Val Thr Leu Asp Gly Gly 
65                  70                  75                  80  


Leu Val Tyr Glu Ala Gly Leu Lys Pro Asn Asn Leu Lys Pro Val Val 
                85                  90                  95      


Ala Glu Phe His Gly Thr Lys Asp Asn Pro Gln Thr His Tyr Tyr Ala 
            100                 105                 110         


Val Ala Val Val Lys Lys Asp Thr Asp Phe Lys Leu Asn Glu Leu Arg 
        115                 120                 125             


Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser Ala Gly Trp Asn 
    130                 135                 140                 


Ile Pro Met Gly Lys Leu Tyr Lys Glu Leu Pro Asp Pro Gln Glu Ser 
145                 150                 155                 160 


Ile Gln Arg Ala Ala Ala Asn Phe Phe Ser Ala Ser Cys Val Pro Cys 
                165                 170                 175     


Ala Asp Gln Ser Ser Phe Pro Lys Leu Cys Gln Leu Cys Ala Gly Lys 
            180                 185                 190         


Gly Thr Asp Lys Cys Ala Cys Ser Asn His Glu Pro Tyr Phe Gly Tyr 
        195                 200                 205             


Ser Gly Ala Phe Lys Cys Leu Met Glu Gly Ala Gly Asp Val Ala Phe 
    210                 215                 220                 


Val Lys His Ser Thr Val Phe Asp Asn Leu Pro Asn Pro Glu Asp Arg 
225                 230                 235                 240 


Lys Asn Tyr Glu Leu Leu Cys Gly Asp Asn Thr Arg Lys Ser Val Asp 
                245                 250                 255     


Asp Tyr Gln Glu Cys Tyr Leu Ala Met Val Pro Ser His Ala Val Val 
            260                 265                 270         


Ala Arg Thr Val Gly Gly Lys Glu Asp Val Ile Trp Glu Leu Leu Asn 
        275                 280                 285             


His Ala Gln Glu His Phe Gly Lys Asp Lys Pro Asp Asn Phe Gln Leu 
    290                 295                 300                 


Phe Gln Ser Pro His Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala Asp 
305                 310                 315                 320 


Gly Phe Leu Lys Ile Pro Ser Lys Met Asp Phe Glu Leu Tyr Leu Gly 
                325                 330                 335     


Tyr Glu Tyr Val Thr Ala Leu Gln Asn Leu Arg Glu Ser Lys Pro Pro 
            340                 345                 350         


Asp Ser Ser Lys Asp Glu Cys Met Val Lys Trp Cys Ala Ile Gly His 
        355                 360                 365             


Gln Glu Arg Thr Lys Cys Asp Arg Trp Ser Gly Phe Ser Gly Gly Ala 
    370                 375                 380                 


Ile Glu Cys Glu Thr Ala Glu Asn Thr Glu Glu Cys Ile Ala Lys Ile 
385                 390                 395                 400 


Met Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Tyr Leu Tyr 
                405                 410                 415     


Ile Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Lys 
            420                 425                 430         


Thr Glu Gly Glu Ser Cys Lys Asn Thr Pro Glu Lys Gly Tyr Leu Ala 
        435                 440                 445             


Val Ala Val Val Lys Thr Ser Asp Ala Asn Ile Asn Trp Asn Asn Leu 
    450                 455                 460                 


Lys Asp Lys Lys Ser Cys His Thr Ala Val Asp Arg Thr Ala Gly Trp 
465                 470                 475                 480 


Asn Ile Pro Met Gly Leu Lys Ile Asn Asn Cys Lys Phe Asp Glu Phe 
                485                 490                 495     


Phe Ser Ala Gly Cys Ala Pro Gly Ser Pro Arg Asn Ser Ser Leu Cys 
            500                 505                 510         


Ala Leu Cys Ile Gly Ser Glu Lys Gly Thr Gly Lys Glu Cys Val Pro 
        515                 520                 525             


Asn Ser Asn Glu Arg Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Lys Gly Asp Val Ala Phe Val Lys Asp Gln Thr Val Ile Gln 
545                 550                 555                 560 


Asn Thr Asp Gly Asn Asn Asn Glu Ala Trp Ala Lys Asn Leu Lys Lys 
                565                 570                 575     


Glu Asn Phe Glu Val Leu Cys Lys Asp Gly Thr Arg Lys Pro Val Thr 
            580                 585                 590         


Asp Ala Glu Asn Cys His Leu Pro Asn His Ala Val Val Ser Arg Lys 
        595                 600                 605             


Asp Lys Ala Thr Cys Val Glu Lys Ile Leu Asn Lys Gln Gln Asp Asp 
    610                 615                 620                 


Phe Gly Lys Ser Val Thr Asp Cys Thr Ser Asn Phe Cys Leu Phe Gln 
625                 630                 635                 640 


Ser Asn Ser Lys Asp Leu Leu Phe Arg Asp Asp Thr Lys Cys Leu Ala 
                645                 650                 655     


Ser Ile Ala Lys Lys Thr Tyr Asp Ser Tyr Leu Gly Asp Asp Tyr Val 
            660                 665                 670         


Arg Ala Met Thr Asn Leu Arg Gln Cys Ser Thr Ser Lys Leu Leu Glu 
        675                 680                 685             


Ala Cys Thr Phe His Lys Pro 
    690                 695 


