                         SEQUENCE LISTING

<110>  University of Louisville Research Foundation, Inc.
       Klein, Jon
       Merchant, Michael
       Boratyn, Grzegorz
 
<120>  PEPTIDE BIOMARKERS PREDICTIVE OF RENAL FUNCTION DECLINE AND 
       KIDNEY DISEASE

<130>  UN024/0UN85

<150>  60/974,002
<151>  2007-09-20

<150>  61/050,521
<151>  2008-05-05

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Oxidation
<222>  (7)..(7)
<223>  Oxidation of sulfur on methionine side chain

<400>  1

Pro Gly Asn Pro Gly Asn Met Met Phe 
1               5                   


<210>  2
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Ser Thr Pro Leu Pro Pro Asp Gly Thr 
1               5                   10  


<210>  3
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Val Ser Ser Gln Asn Leu Ser Leu Asn Asp 
1               5                   10      


<210>  4
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  4

Ile Gly Pro Ile Gly Pro Ile Gly Pro Thr Gly Pro Ala Ala Pro 
1               5                   10                  15  


<210>  5
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  5

Ile Ile Ala Asp Arg Pro Gly Leu Pro Gly Pro Glu His 
1               5                   10              


<210>  6
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Pro Glu Phe Gln Gln His Leu Tyr Glu Ala 
1               5                   10      


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Leu Pro Gly Pro Lys Gly Ser Pro Gly Ser Val Gly Leu Lys Gly 
1               5                   10                  15  


<210>  8
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Hydroxyl group
<222>  (6)..(6)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (12)..(12)
<223>  Hydroxyl group

<400>  8

Pro Gly Leu Pro Gly Pro Pro Gly Pro Met Asp Pro Asn Leu 
1               5                   10                  


<210>  9
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Hydroxyl group
<222>  (3)..(3)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (9)..(9)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (15)..(15)
<223>  Hydroxyl group

<400>  9

Gly Ser Pro Gly Ser Asn Gly Ala Pro Gly Gln Arg Gly Glu Pro Gly 
1               5                   10                  15      


Pro Gln 
        


<210>  10
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  10

Thr Lys Leu Lys Lys Thr Pro Thr Glu Ala Pro Ala Asp Cys Arg Ala 
1               5                   10                  15      


Leu 
    


<210>  11
<211>  22
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Hydroxyl group
<222>  (4)..(4)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (9)..(9)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (10)..(10)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (21)..(21)
<223>  Hydroxyl group

<400>  11

Gln Gly Leu Pro Gly Thr Gly Gly Pro Pro Gly Glu Asn Gly Lys Pro 
1               5                   10                  15      


Gly Glu Pro Gly Pro Lys 
            20          


<210>  12
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Glycine-Glycine
<222>  (10)..(10)
<223>  Glycine-Glycine dipeptide addition to the side chain epsilon 
       amino group of lysine

<400>  12

Glu Trp Gly Tyr His Gly Glu Gly Asn Lys Ser Leu Val Val Ala His 
1               5                   10                  15      


Ala Gln 
        


<210>  13
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Hydroxyl group
<222>  (4)..(4)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (16)..(16)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (19)..(19)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (25)..(25)
<223>  Hydroxyl group

<400>  13

Asn Gly Ala Pro Gly Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro 
1               5                   10                  15      


Gly Ala Pro Gly Ser Gln Gly Ala Pro Gly Leu 
            20                  25          


<210>  14
<211>  24
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Hydroxyl group
<222>  (4)..(4)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (8)..(8)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (11)..(11)
<223>  Hydroxyl group

<400>  14

Ser Pro Gly Pro Trp Gly Ala Pro Gly Leu Pro Gly Glu Lys Gly Asp 
1               5                   10                  15      


His Gly Phe Pro Gly Ser Ser Gly 
            20                  


<210>  15
<211>  25
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Hydroxyl group
<222>  (8)..(8)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (21)..(21)
<223>  Hydroxyl group

<400>  15

Gly Lys Asn Gly Glu Tyr Gly Pro Gln Gly Pro Pro Gly Pro Thr Gly 
1               5                   10                  15      


Pro Gly Gly Asp Lys Gly Asp Thr Gly 
            20                  25  


<210>  16
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Hydroxyl group
<222>  (18)..(18)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (23)..(23)
<223>  Hydroxyl group

<400>  16

Gly Pro Lys Gly Arg Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly 
1               5                   10                  15      


Pro Pro Gly Glu Lys Gly Lys Leu Gly Val 
            20                  25      


<210>  17
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  17

Leu Leu Ser Asp Pro Glu Gln Gly Val Glu Val Thr Gly Gln Tyr Glu 
1               5                   10                  15      


Arg Glu Lys Ala Gly Phe Ser 
            20              


<210>  18
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Hydroxyl group
<222>  (13)..(13)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (16)..(16)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (22)..(22)
<223>  Hydroxyl group

<400>  18

Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg Pro 
1               5                   10                  15      


Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly 
            20                  25      


<210>  19
<211>  22
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Hydroxyl group
<222>  (17)..(17)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (18)..(18)
<223>  Hydroxyl group

<400>  19

Gln Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu Met Ile Ile 
1               5                   10                  15      


Lys Asn Ser Thr Tyr Arg 
            20          


<210>  20
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Hydroxyl group
<222>  (7)..(7)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (8)..(8)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (17)..(17)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (20)..(20)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (23)..(23)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (28)..(28)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (29)..(29)
<223>  Hydroxyl group

<400>  20

Pro Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Thr Ser Gly His 
1               5                   10                  15      


Pro Gly Ser Pro Gly Ser Pro Gly Tyr Gln Gly Pro Pro Gly Glu Pro 
            20                  25                  30          


Gly Gln Ala Gly Pro Ser 
        35              


<210>  21
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  21

Thr Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly Gly Val 
1               5                   10                  15      


Arg Gly 
        


<210>  22
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  22

Thr Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly Gly Val 
1               5                   10                  15      


Arg Gly 
        


<210>  23
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  23

Lys Met Ala Asp Glu Ala Gly Ser Glu Ala Asp His Glu Gly Thr His 
1               5                   10                  15      


Ser Thr Lys Arg Gly His Ala Lys Ser Arg Pro Val Arg 
            20                  25                  


<210>  24
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Oxidation
<222>  (2)..(2)
<223>  Oxidation of sulfur on methionine side chain

<400>  24

Lys Met Ala Asp Glu Ala Gly Ser Glu Ala Asp His Glu Gly Thr His 
1               5                   10                  15      


Ser Thr Lys Arg Gly His Ala Lys Ser Arg Pro Val Arg 
            20                  25                  


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  25

Lys Arg Pro Pro Gly Phe Ser Pro Phe 
1               5                   


<210>  26
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  26

Lys Arg Pro Pro Gly Phe Ser Pro Phe Arg 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Hydroxl group
<222>  (4)..(4)
<223>  Hydroxl group

<400>  27

Lys Arg Pro Pro Gly Phe Ser Pro Phe Arg 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Hydroxyl group
<222>  (8)..(8)
<223>  Hydroxyl group

<400>  28

Lys Arg Pro Pro Gly Phe Ser Pro Phe Arg 
1               5                   10  


<210>  29
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  29

Lys Arg Pro Pro Gly Phe Ser Pro Phe Arg Lys 
1               5                   10      


<210>  30
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Hydroxyl group
<222>  (4)..(4)
<223>  Hydroxyl group

<220>
<221>  Hydroxyl group
<222>  (8)..(8)
<223>  Hydroxyl group

<400>  30

Lys Arg Pro Pro Gly Phe Ser Pro Phe Arg Lys 
1               5                   10      


<210>  31
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  31

His Asp Trp Gly His Glu Lys Gln Arg Lys 
1               5                   10  


<210>  32
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  32

His Asn Leu Gly His Gly His Lys His Glu Arg Asp Gln Gly His Gly 
1               5                   10                  15      


His Gln Arg 
            


<210>  33
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Asn Phe Arg Pro Gly Val Leu Ser Ser Arg 
1               5                   10      


<210>  34
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  34

Leu Gly Leu Pro Gly Pro Pro Asp Val Pro Asp His Ala Ala Tyr His 
1               5                   10                  15      


Pro Phe Arg 
            


<210>  35
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  35

Pro Gly Pro Pro Asp Val Pro Asp His Ala Ala Tyr His Pro Phe Arg 
1               5                   10                  15      


Arg 
    


<210>  36
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  36

Asp His Ala Ala Tyr His Pro Phe Arg 
1               5                   


<210>  37
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Optional carboxylation
<222>  (3)..(3)
<223>  Optional carboxylation of glutamic acid side chain

<220>
<221>  Optional carboxylation
<222>  (6)..(6)
<223>  Optional carboxylation of glutamic acid side chain

<400>  37

Gln Asp Glu Gly Ala Glu Pro Leu Lys Gln Arg 
1               5                   10      


<210>  38
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  38

Arg Asn Gly Phe Lys Ser His Ala Leu Gln Leu Asn Asn Arg 
1               5                   10                  


<210>  39
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Carboxylation
<222>  (2)..(2)
<223>  Gamma carboxylation of glutamic acid side chain

<400>  39

Pro Glu Pro Pro Thr Ser Ala Ser Ile Leu Ser 
1               5                   10      


<210>  40
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  40

Leu Ile Cys His Thr Gly His Glu Gln Ala Gly Arg 
1               5                   10          


<210>  41
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  41

Leu Ile Cys His Thr Gly His Glu Gln Ala Gly Arg Glu 
1               5                   10              


<210>  42
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  42

Asp Asp Asp Met Ser Gly Asp Glu Lys Gln Asp 
1               5                   10      


<210>  43
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Carboxylation
<222>  (4)..(4)
<223>  Gamma carboxylation of glutamic acid side chain

<400>  43

Tyr Ile Arg Glu Gly His Glu Lys Gln Ala 
1               5                   10  


<210>  44
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Carboxylation
<222>  (7)..(7)
<223>  Gamma carboxylation of glutamic acid side chain

<400>  44

Tyr Ile Arg Glu Gly His Glu Lys Gln Ala 
1               5                   10  


<210>  45
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  45

Thr Met Ala Glu Ala Ser Glu Asp Ser Pro Arg 
1               5                   10      


<210>  46
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Optional hydroxyl group
<222>  (4)..(4)
<223>  Optional hydroxyl group

<220>
<221>  Optional hydroxyl group
<222>  (11)..(11)
<223>  Optional hydroxyl group

<400>  46

Leu Arg Ser Pro Ser Ser Leu Leu His Asp Pro Ala Leu His 
1               5                   10                  


<210>  47
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Optional hydroxyl group
<222>  (2)..(2)
<223>  Optional hydroxyl group

<220>
<221>  Optional hydroxyl group
<222>  (4)..(4)
<223>  Optional hydroxyl group

<220>
<221>  Optional hydroxyl group
<222>  (6)..(6)
<223>  Optional hydroxyl group

<400>  47

Ser Pro Thr Pro Arg Pro Arg Arg Met Lys Lys Asp Glu Ser Phe 
1               5                   10                  15  


<210>  48
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  48

Arg Val Ser Val His Pro Asp Tyr Arg Gln 
1               5                   10  


<210>  49
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Carboxylation
<222>  (5)..(5)
<223>  Gamma carboxylation of glutamic acid side chain

<220>
<221>  Hydroxyl group
<222>  (11)..(11)
<223>  Hydroxyl group

<400>  49

Tyr Thr Asp Ser Glu Ser Ser Ala Ser Leu Pro Arg Ser 
1               5                   10              


<210>  50
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Optional hydroxyl group
<222>  (12)..(12)
<223>  Optional hydroxyl group

<220>
<221>  Optional hydroxyl group
<222>  (13)..(13)
<223>  Optional hydroxyl group

<220>
<221>  Optional hydroxyl group
<222>  (14)..(14)
<223>  Optional hydroxyl group

<400>  50

Asp Arg Arg Thr Gln Glu Gly Gly Arg Gly Asp Pro Pro Pro Ala Gly 
1               5                   10                  15      


Arg Ser 
        


<210>  51
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  51

Val Asp His Pro Asn Glu Glu Gln Gln Lys 
1               5                   10  


<210>  52
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Optional carboxylation
<222>  (6)..(6)
<223>  Optional carboxylation of glutamic acid side chain

<220>
<221>  Optional carboxylation
<222>  (7)..(7)
<223>  Optional carboxylation of glutamic acid side chain

<400>  52

Val Asp His Pro Asn Glu Glu Gln Gln Lys 
1               5                   10  


<210>  53
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Hydroxyl group
<222>  (9)..(9)
<223>  Hydroxyl group

<400>  53

Pro Gly Leu Glu Ser Gly Asp Ile Pro Ser Pro 
1               5                   10      


<210>  54
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  54

Leu Pro His Asp Ser Gly Gln Gln His 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Carboxylation
<222>  (3)..(3)
<223>  Gamma carboxylation of glutamic acid side chain

<220>
<221>  Hydroxyl group
<222>  (6)..(6)
<223>  Hydroxyl group

<400>  55

Ser Arg Glu Thr Ser Pro Asn Arg Ile 
1               5                   


<210>  56
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Optional hydroxyl group
<222>  (6)..(6)
<223>  Optional hydroxyl group

<220>
<221>  Optional hydroxyl group
<222>  (7)..(7)
<223>  Optional hydroxyl group

<220>
<221>  Optional hydroxyl group
<222>  (15)..(15)
<223>  Optional hydroxyl group

<400>  56

Arg His Arg Ser His Pro Pro Gly Trp Ala Ser Gly Ala Arg Pro 
1               5                   10                  15  


<210>  57
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Carboxylation
<222>  (5)..(5)
<223>  Gamma carboxylation of glutamic acid side chain

<220>
<221>  Hydroxyl group
<222>  (6)..(6)
<223>  Hydroxyl group

<400>  57

Ala Asn Gly Ala Glu Pro Ser Arg Ala Val Gly Thr 
1               5                   10          


<210>  58
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Hydroxyl group
<222>  (8)..(8)
<223>  Hydroxyl group

<220>
<221>  Optional carboxylation
<222>  (10)..(10)
<223>  Optional carboxylation of glutamic acid side chain

<220>
<221>  Optional carboxylation
<222>  (11)..(11)
<223>  Optional carboxylation of glutamic acid side chain

<220>
<221>  Hydroxyl group
<222>  (14)..(14)
<223>  Hydroxyl group

<400>  58

Ala Arg Thr Asp Glu Val Leu Pro Glu Glu Ala Ala Pro Arg Arg Lys 
1               5                   10                  15      


Met 
    


<210>  59
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  59

His Tyr Glu Asn Gly Glu Tyr Ile Ile Arg Gln Gly Ala Arg Gly Asp 
1               5                   10                  15      


Thr 
    


