                         SEQUENCE LISTING

<110>  Chang, Yung-Fu
 
<120>  Immunogenic proteins from genome-derived outer membrane of 
       Leptospira and compositions and methods based thereon

<130>  1258_3959PCT

<150>  60/976,088
<151>  2007-09-28

<150>  60/974,818
<151>  2007-09-24

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  1077
<212>  DNA
<213>  Leptospira interrogans serovar Pomona


<220>
<221>  CDS
<222>  (1)..(1077)

<300>
<308>  GenBank / AAN48653
<309>  2006-02-01
<313>  (1)..(1077)

<400>  1
gtg ggg aaa aac aat tcg ttc aga ccg aaa aat tct ttc tta aag ttc         48
Met Gly Lys Asn Asn Ser Phe Arg Pro Lys Asn Ser Phe Leu Lys Phe           
1               5                   10                  15                

caa gtt gta ttc ggt ttt ttt ctt ttg agt ttt att tct tta aat tca         96
Gln Val Val Phe Gly Phe Phe Leu Leu Ser Phe Ile Ser Leu Asn Ser           
            20                  25                  30                    

gaa gaa aga tcc tca att tta gat cct acg ttt ttt tta att cat aag        144
Glu Glu Arg Ser Ser Ile Leu Asp Pro Thr Phe Phe Leu Ile His Lys           
        35                  40                  45                        

aat ctg aat cct tct tta gga ggt tta ttc gaa acc aga aaa aaa ttt        192
Asn Leu Asn Pro Ser Leu Gly Gly Leu Phe Glu Thr Arg Lys Lys Phe           
    50                  55                  60                            

act tct tat gga gcc tgg ttt gaa ctt cca gtt tgg aaa cga gaa cgt        240
Thr Ser Tyr Gly Ala Trp Phe Glu Leu Pro Val Trp Lys Arg Glu Arg           
65                  70                  75                  80            

aaa cat ttt tgg aaa acc cat ttt ctt tat gag aat cac aag act ttt        288
Lys His Phe Trp Lys Thr His Phe Leu Tyr Glu Asn His Lys Thr Phe           
                85                  90                  95                

tca gtc gtt cat caa act tac ata gga ctt gaa tat tct ttt att tca        336
Ser Val Val His Gln Thr Tyr Ile Gly Leu Glu Tyr Ser Phe Ile Ser           
            100                 105                 110                   

gaa aag aag gat ctg cac cct tcc gtt ttt gta ggt tgg gaa aga gga        384
Glu Lys Lys Asp Leu His Pro Ser Val Phe Val Gly Trp Glu Arg Gly           
        115                 120                 125                       

gaa aag gat tta gga att ttc gga atc cac ctt aca att ccg gac aaa        432
Glu Lys Asp Leu Gly Ile Phe Gly Ile His Leu Thr Ile Pro Asp Lys           
    130                 135                 140                           

caa acg atc caa gtt ttt gga aaa act gga aaa gat ttt aaa agt ggt        480
Gln Thr Ile Gln Val Phe Gly Lys Thr Gly Lys Asp Phe Lys Ser Gly           
145                 150                 155                 160           

tct atc ttt ctt cat tct aac ttt gat act gga ctt caa tta ttt tta        528
Ser Ile Phe Leu His Ser Asn Phe Asp Thr Gly Leu Gln Leu Phe Leu           
                165                 170                 175               

gga ttt tca agg aca tgg gac aaa tcc tat acc gaa gat caa ttc act        576
Gly Phe Ser Arg Thr Trp Asp Lys Ser Tyr Thr Glu Asp Gln Phe Thr           
            180                 185                 190                   

ctt gga atc agg gtt tct tgg gaa aaa att tac tct tct ttt ttc tgg        624
Leu Gly Ile Arg Val Ser Trp Glu Lys Ile Tyr Ser Ser Phe Phe Trp           
        195                 200                 205                       

aat caa acg cag gaa gaa gaa tca ttt cta acc ggg aaa ttt gga atc        672
Asn Gln Thr Gln Glu Glu Glu Ser Phe Leu Thr Gly Lys Phe Gly Ile           
    210                 215                 220                           

agt aat ttc caa caa gat ctc aaa tct aaa aca ctt ttt gaa tcc aca        720
Ser Asn Phe Gln Gln Asp Leu Lys Ser Lys Thr Leu Phe Glu Ser Thr           
225                 230                 235                 240           

gac gaa ttt cag tcg aat tca ctt ttt aaa tct aaa aat tta agt tct        768
Asp Glu Phe Gln Ser Asn Ser Leu Phe Lys Ser Lys Asn Leu Ser Ser           
                245                 250                 255               

aaa aac aca aaa tca aaa tcg ttc gaa act tct ctt tta gaa aaa gat        816
Lys Asn Thr Lys Ser Lys Ser Phe Glu Thr Ser Leu Leu Glu Lys Asp           
            260                 265                 270                   

aaa aca aat tat tcc tac ata agt tca ttt att cgt agt tat acg aat        864
Lys Thr Asn Tyr Ser Tyr Ile Ser Ser Phe Ile Arg Ser Tyr Thr Asn           
        275                 280                 285                       

att tcg att tcc gtt cag gaa tta ttg tcc gcc ggt ttt act ctt tcc        912
Ile Ser Ile Ser Val Gln Glu Leu Leu Ser Ala Gly Phe Thr Leu Ser           
    290                 295                 300                           

tcc gct ttg gaa att tct aag gcg agc tat aac tct aaa gaa gaa ttt        960
Ser Ala Leu Glu Ile Ser Lys Ala Ser Tyr Asn Ser Lys Glu Glu Phe           
305                 310                 315                 320           

cta aag tta ttt cat tct ctt tca gta aaa gaa caa acc aaa att ttc       1008
Leu Lys Leu Phe His Ser Leu Ser Val Lys Glu Gln Thr Lys Ile Phe           
                325                 330                 335               

gtt ctt ttg aaa aag aaa aat ccg aag cac att ctt aaa aat tca att       1056
Val Leu Leu Lys Lys Lys Asn Pro Lys His Ile Leu Lys Asn Ser Ile           
            340                 345                 350                   

ctt ccc aaa gat aaa aga tga                                           1077
Leu Pro Lys Asp Lys Arg                                                   
        355                                                               


<210>  2
<211>  358
<212>  PRT
<213>  Leptospira interrogans serovar Pomona

<400>  2

Met Gly Lys Asn Asn Ser Phe Arg Pro Lys Asn Ser Phe Leu Lys Phe 
1               5                   10                  15      


Gln Val Val Phe Gly Phe Phe Leu Leu Ser Phe Ile Ser Leu Asn Ser 
            20                  25                  30          


Glu Glu Arg Ser Ser Ile Leu Asp Pro Thr Phe Phe Leu Ile His Lys 
        35                  40                  45              


Asn Leu Asn Pro Ser Leu Gly Gly Leu Phe Glu Thr Arg Lys Lys Phe 
    50                  55                  60                  


Thr Ser Tyr Gly Ala Trp Phe Glu Leu Pro Val Trp Lys Arg Glu Arg 
65                  70                  75                  80  


Lys His Phe Trp Lys Thr His Phe Leu Tyr Glu Asn His Lys Thr Phe 
                85                  90                  95      


Ser Val Val His Gln Thr Tyr Ile Gly Leu Glu Tyr Ser Phe Ile Ser 
            100                 105                 110         


Glu Lys Lys Asp Leu His Pro Ser Val Phe Val Gly Trp Glu Arg Gly 
        115                 120                 125             


Glu Lys Asp Leu Gly Ile Phe Gly Ile His Leu Thr Ile Pro Asp Lys 
    130                 135                 140                 


Gln Thr Ile Gln Val Phe Gly Lys Thr Gly Lys Asp Phe Lys Ser Gly 
145                 150                 155                 160 


Ser Ile Phe Leu His Ser Asn Phe Asp Thr Gly Leu Gln Leu Phe Leu 
                165                 170                 175     


Gly Phe Ser Arg Thr Trp Asp Lys Ser Tyr Thr Glu Asp Gln Phe Thr 
            180                 185                 190         


Leu Gly Ile Arg Val Ser Trp Glu Lys Ile Tyr Ser Ser Phe Phe Trp 
        195                 200                 205             


Asn Gln Thr Gln Glu Glu Glu Ser Phe Leu Thr Gly Lys Phe Gly Ile 
    210                 215                 220                 


Ser Asn Phe Gln Gln Asp Leu Lys Ser Lys Thr Leu Phe Glu Ser Thr 
225                 230                 235                 240 


Asp Glu Phe Gln Ser Asn Ser Leu Phe Lys Ser Lys Asn Leu Ser Ser 
                245                 250                 255     


Lys Asn Thr Lys Ser Lys Ser Phe Glu Thr Ser Leu Leu Glu Lys Asp 
            260                 265                 270         


Lys Thr Asn Tyr Ser Tyr Ile Ser Ser Phe Ile Arg Ser Tyr Thr Asn 
        275                 280                 285             


Ile Ser Ile Ser Val Gln Glu Leu Leu Ser Ala Gly Phe Thr Leu Ser 
    290                 295                 300                 


Ser Ala Leu Glu Ile Ser Lys Ala Ser Tyr Asn Ser Lys Glu Glu Phe 
305                 310                 315                 320 


Leu Lys Leu Phe His Ser Leu Ser Val Lys Glu Gln Thr Lys Ile Phe 
                325                 330                 335     


Val Leu Leu Lys Lys Lys Asn Pro Lys His Ile Leu Lys Asn Ser Ile 
            340                 345                 350         


Leu Pro Lys Asp Lys Arg 
        355             


<210>  3
<211>  951
<212>  DNA
<213>  Leptospira interrogans serovar Pomona


<220>
<221>  CDS
<222>  (1)..(951)

<300>
<308>  GenBank / AAN48316 
<309>  2006-02-01
<313>  (1)..(951)

<400>  3
gtg aaa cat cca aaa atg aac ctc ttg gga gcg ctt tta ctt agc tcc         48
Met Lys His Pro Lys Met Asn Leu Leu Gly Ala Leu Leu Leu Ser Ser           
1               5                   10                  15                

tta ttc tta aat cct ttg aat tcc gac cct acg tta ggc aac tgt gaa         96
Leu Phe Leu Asn Pro Leu Asn Ser Asp Pro Thr Leu Gly Asn Cys Glu           
            20                  25                  30                    

gta ttt cca aca aat aat att tgg aat act ccc gta gat aca ctt ccc        144
Val Phe Pro Thr Asn Asn Ile Trp Asn Thr Pro Val Asp Thr Leu Pro           
        35                  40                  45                        

ctg cat cct ttt tca gaa tct tat gtt cga agt att gga gca caa aaa        192
Leu His Pro Phe Ser Glu Ser Tyr Val Arg Ser Ile Gly Ala Gln Lys           
    50                  55                  60                            

aaa tta aaa gcg gat ttc ggc tct ggg ctt tgg gag gga atg cca att        240
Lys Leu Lys Ala Asp Phe Gly Ser Gly Leu Trp Glu Gly Met Pro Ile           
65                  70                  75                  80            

gga att cca ttt ata cta acg tct ggt gcc aat cct gtc cca gta tct        288
Gly Ile Pro Phe Ile Leu Thr Ser Gly Ala Asn Pro Val Pro Val Ser           
                85                  90                  95                

ttt gaa tat act gat gaa agt gaa cct gga ccg tat cca att cca cat        336
Phe Glu Tyr Thr Asp Glu Ser Glu Pro Gly Pro Tyr Pro Ile Pro His           
            100                 105                 110                   

aac gca cct ata gaa ggt gga gaa aca agc gac gga gac agg cac gtt        384
Asn Ala Pro Ile Glu Gly Gly Glu Thr Ser Asp Gly Asp Arg His Val           
        115                 120                 125                       

cta gtt gta gag caa aaa aca tgc aag tta tat gaa ttg tat tcc gca        432
Leu Val Val Glu Gln Lys Thr Cys Lys Leu Tyr Glu Leu Tyr Ser Ala           
    130                 135                 140                           

agg aaa aaa gga aaa tct tgg act gct gtg tct ggt gcg gtc ttt gat        480
Arg Lys Lys Gly Lys Ser Trp Thr Ala Val Ser Gly Ala Val Phe Asp           
145                 150                 155                 160           

ttg aag tcc aat caa ctt cgt ccg gct aac tgg act tct gcg gac gca        528
Leu Lys Ser Asn Gln Leu Arg Pro Ala Asn Trp Thr Ser Ala Asp Ala           
                165                 170                 175               

gcc gga cta cca att tta cct ggt tta gtg aga tac gaa gaa ata gct        576
Ala Gly Leu Pro Ile Leu Pro Gly Leu Val Arg Tyr Glu Glu Ile Ala           
            180                 185                 190                   

tct gga gaa atc aaa cac gca att cgt ttc acc gct aaa aaa aca caa        624
Ser Gly Glu Ile Lys His Ala Ile Arg Phe Thr Ala Lys Lys Thr Gln           
        195                 200                 205                       

aaa gcg tat cta tgg cct gct cgt cat tac gct tct aaa atc aca gac        672
Lys Ala Tyr Leu Trp Pro Ala Arg His Tyr Ala Ser Lys Ile Thr Asp           
    210                 215                 220                           

aaa aac gtc cca ccg atg gga act cgt ttc cgt tta aaa gca agt ttt        720
Lys Asn Val Pro Pro Met Gly Thr Arg Phe Arg Leu Lys Ala Ser Phe           
225                 230                 235                 240           

aac ata gac gga ttt agt aaa gaa aac caa gta att cta cgt gca tta        768
Asn Ile Asp Gly Phe Ser Lys Glu Asn Gln Val Ile Leu Arg Ala Leu           
                245                 250                 255               

aaa aaa tat gga atg ata ctt gcc gac aac gga tca gat tgg ttt tta        816
Lys Lys Tyr Gly Met Ile Leu Ala Asp Asn Gly Ser Asp Trp Phe Leu           
            260                 265                 270                   

tcc gga gct cca aac gaa aaa tgg aac aat gat caa ctt cat aaa cta        864
Ser Gly Ala Pro Asn Glu Lys Trp Asn Asn Asp Gln Leu His Lys Leu           
        275                 280                 285                       

ggt aag gtt tta gga gat cag ttc gaa gca gta gat tca gaa agt tta        912
Gly Lys Val Leu Gly Asp Gln Phe Glu Ala Val Asp Ser Glu Ser Leu           
    290                 295                 300                           

atg att tcg aca gat tcc gga gaa gcc aaa caa aac taa                    951
Met Ile Ser Thr Asp Ser Gly Glu Ala Lys Gln Asn                           
305                 310                 315                               


<210>  4
<211>  316
<212>  PRT
<213>  Leptospira interrogans serovar Pomona

<400>  4

Met Lys His Pro Lys Met Asn Leu Leu Gly Ala Leu Leu Leu Ser Ser               
 		5                   10                  15      


Leu Phe Leu Asn Pro Leu Asn Ser Asp Pro Thr Leu Gly Asn Cys Glu 
            20                  25                  30          


Val Phe Pro Thr Asn Asn Ile Trp Asn Thr Pro Val Asp Thr Leu Pro 
        35                  40                  45              


Leu His Pro Phe Ser Glu Ser Tyr Val Arg Ser Ile Gly Ala Gln Lys 
    50                  55                  60                  


Lys Leu Lys Ala Asp Phe Gly Ser Gly Leu Trp Glu Gly Met Pro Ile 
65                  70                  75                  80  


Gly Ile Pro Phe Ile Leu Thr Ser Gly Ala Asn Pro Val Pro Val Ser 
                85                  90                  95      


Phe Glu Tyr Thr Asp Glu Ser Glu Pro Gly Pro Tyr Pro Ile Pro His 
            100                 105                 110         


Asn Ala Pro Ile Glu Gly Gly Glu Thr Ser Asp Gly Asp Arg His Val 
        115                 120                 125             


Leu Val Val Glu Gln Lys Thr Cys Lys Leu Tyr Glu Leu Tyr Ser Ala 
    130                 135                 140                 


Arg Lys Lys Gly Lys Ser Trp Thr Ala Val Ser Gly Ala Val Phe Asp 
145                 150                 155                 160 


Leu Lys Ser Asn Gln Leu Arg Pro Ala Asn Trp Thr Ser Ala Asp Ala 
                165                 170                 175     


Ala Gly Leu Pro Ile Leu Pro Gly Leu Val Arg Tyr Glu Glu Ile Ala 
            180                 185                 190         


Ser Gly Glu Ile Lys His Ala Ile Arg Phe Thr Ala Lys Lys Thr Gln 
        195                 200                 205             


Lys Ala Tyr Leu Trp Pro Ala Arg His Tyr Ala Ser Lys Ile Thr Asp 
    210                 215                 220                 


Lys Asn Val Pro Pro Met Gly Thr Arg Phe Arg Leu Lys Ala Ser Phe 
225                 230                 235                 240 


Asn Ile Asp Gly Phe Ser Lys Glu Asn Gln Val Ile Leu Arg Ala Leu 
                245                 250                 255     


Lys Lys Tyr Gly Met Ile Leu Ala Asp Asn Gly Ser Asp Trp Phe Leu 
            260                 265                 270         


Ser Gly Ala Pro Asn Glu Lys Trp Asn Asn Asp Gln Leu His Lys Leu 
        275                 280                 285             


Gly Lys Val Leu Gly Asp Gln Phe Glu Ala Val Asp Ser Glu Ser Leu 
    290                 295                 300                 


Met Ile Ser Thr Asp Ser Gly Glu Ala Lys Gln Asn 
305                 310                 315     


<210>  5
<211>  480
<212>  DNA
<213>  Leptospira interrogans serovar Pomona


<220>
<221>  CDS
<222>  (1)..(480)

<300>
<308>  GenBank /  AAN49138
<309>  2006-02-01
<313>  (1)..(480)

<400>  5
atg aaa aaa cat tct atc agt aaa atc att ata act gct tgt tgc att         48
Met Lys Lys His Ser Ile Ser Lys Ile Ile Ile Thr Ala Cys Cys Ile           
1               5                   10                  15                

ttt ctt tta aca tac gga tgc aaa caa gat cca gta gat tac aat aat         96
Phe Leu Leu Thr Tyr Gly Cys Lys Gln Asp Pro Val Asp Tyr Asn Asn           
            20                  25                  30                    

aaa atc atg gaa atc atg aac gct tct aca aac gat tta gat gcg tta        144
Lys Ile Met Glu Ile Met Asn Ala Ser Thr Asn Asp Leu Asp Ala Leu           
        35                  40                  45                        

aac gca gcc atg gaa aag gaa gac ctt aca aac gca gaa aat gtt aga        192
Asn Ala Ala Met Glu Lys Glu Asp Leu Thr Asn Ala Glu Asn Val Arg           
    50                  55                  60                            

aaa gct tgg gaa aca aag cta gtt tct tca ctc gat aag ctt aaa gga        240
Lys Ala Trp Glu Thr Lys Leu Val Ser Ser Leu Asp Lys Leu Lys Gly           
65                  70                  75                  80            

atc agt gat ttt aaa gga gat tcc agt ttt aaa aat gca agc gtc caa        288
Ile Ser Asp Phe Lys Gly Asp Ser Ser Phe Lys Asn Ala Ser Val Gln           
                85                  90                  95                

gct ctc gaa act tat ttg aac ata gta agt aaa gac tac aaa cgt ttg        336
Ala Leu Glu Thr Tyr Leu Asn Ile Val Ser Lys Asp Tyr Lys Arg Leu           
            100                 105                 110                   

atc gaa tta cga gga tta ggt gac aaa gca gac tca aat gaa atc aac        384
Ile Glu Leu Arg Gly Leu Gly Asp Lys Ala Asp Ser Asn Glu Ile Asn           
        115                 120                 125                       

caa gtt ctc aat cgt att aat cag gat ttt gaa aaa gct gca aat act        432
Gln Val Leu Asn Arg Ile Asn Gln Asp Phe Glu Lys Ala Ala Asn Thr           
    130                 135                 140                           

ctc aat gct gct tct gat aaa ttt gcg aaa gaa tac gct tct caa taa        480
Leu Asn Ala Ala Ser Asp Lys Phe Ala Lys Glu Tyr Ala Ser Gln               
145                 150                 155                               


<210>  6
<211>  159
<212>  PRT
<213>  Leptospira interrogans serovar Pomona

<400>  6

Met Lys Lys His Ser Ile Ser Lys Ile Ile Ile Thr Ala Cys Cys Ile 
1               5                   10                  15      


Phe Leu Leu Thr Tyr Gly Cys Lys Gln Asp Pro Val Asp Tyr Asn Asn 
            20                  25                  30          


Lys Ile Met Glu Ile Met Asn Ala Ser Thr Asn Asp Leu Asp Ala Leu 
        35                  40                  45              


Asn Ala Ala Met Glu Lys Glu Asp Leu Thr Asn Ala Glu Asn Val Arg 
    50                  55                  60                  


Lys Ala Trp Glu Thr Lys Leu Val Ser Ser Leu Asp Lys Leu Lys Gly 
65                  70                  75                  80  


Ile Ser Asp Phe Lys Gly Asp Ser Ser Phe Lys Asn Ala Ser Val Gln 
                85                  90                  95      


Ala Leu Glu Thr Tyr Leu Asn Ile Val Ser Lys Asp Tyr Lys Arg Leu 
            100                 105                 110         


Ile Glu Leu Arg Gly Leu Gly Asp Lys Ala Asp Ser Asn Glu Ile Asn 
        115                 120                 125             


Gln Val Leu Asn Arg Ile Asn Gln Asp Phe Glu Lys Ala Ala Asn Thr 
    130                 135                 140                 


Leu Asn Ala Ala Ser Asp Lys Phe Ala Lys Glu Tyr Ala Ser Gln 
145                 150                 155                 


<210>  7
<211>  801
<212>  DNA
<213>  Leptospira interrogans serovar Pomona


<220>
<221>  CDS
<222>  (1)..(801)

<400>  7
atg aat ctt tcc aaa cac aca gcc gtt ctc aca ggg att gtt ttc ttc         48
Met Asn Leu Ser Lys His Thr Ala Val Leu Thr Gly Ile Val Phe Phe           
1               5                   10                  15                

tta gca ttt tcc tta agt atg tat gtc tcc gtt att gaa aaa gcc gga         96
Leu Ala Phe Ser Leu Ser Met Tyr Val Ser Val Ile Glu Lys Ala Gly           
            20                  25                  30                    

acc aaa gac gaa tat cca tat acc atg aaa att tat tat ccc cgt ttg        144
Thr Lys Asp Glu Tyr Pro Tyr Thr Met Lys Ile Tyr Tyr Pro Arg Leu           
        35                  40                  45                        

gaa gga att cat cca ggt gca ccc gtt cga att tta gga gta gaa aaa        192
Glu Gly Ile His Pro Gly Ala Pro Val Arg Ile Leu Gly Val Glu Lys           
    50                  55                  60                            

gga att gta cgt agt tta gac gtg gtt ccg att gac gaa gta gaa gat        240
Gly Ile Val Arg Ser Leu Asp Val Val Pro Ile Asp Glu Val Glu Asp           
65                  70                  75                  80            

caa aga ttc ctc aat aag gat caa acg aag gca atc gaa att att gtt        288
Gln Arg Phe Leu Asn Lys Asp Gln Thr Lys Ala Ile Glu Ile Ile Val           
                85                  90                  95                

aga ctg aaa gag cca atc aca ctc tgg gac aat tat aaa att aca ttc        336
Arg Leu Lys Glu Pro Ile Thr Leu Trp Asp Asn Tyr Lys Ile Thr Phe           
            100                 105                 110                   

caa acc aac acg att ctc tct gga aga acc atc gat ata gac cct gga        384
Gln Thr Asn Thr Ile Leu Ser Gly Arg Thr Ile Asp Ile Asp Pro Gly           
        115                 120                 125                       

tct ttc gat aaa gaa gag acg tcc ttt ttt caa cct act tac tta gaa        432
Ser Phe Asp Lys Glu Glu Thr Ser Phe Phe Gln Pro Thr Tyr Leu Glu           
    130                 135                 140                           

gaa gaa caa aaa tct cca gac ttc tta cct tct gca gat tac ttt gaa        480
Glu Glu Gln Lys Ser Pro Asp Phe Leu Pro Ser Ala Asp Tyr Phe Glu           
145                 150                 155                 160           

gat ttt ttc gcg gct tcc acg gga gtc atc cga gaa aat cgt gaa gac        528
Asp Phe Phe Ala Ala Ser Thr Gly Val Ile Arg Glu Asn Arg Glu Asp           
                165                 170                 175               

atc cga act tct ttt aat aat ttt tat gaa att tca gaa aaa ttg aaa        576
Ile Arg Thr Ser Phe Asn Asn Phe Tyr Glu Ile Ser Glu Lys Leu Lys           
            180                 185                 190                   

tca aat cga gga aca att cct cag atc att aac tct ccg gaa acg tac        624
Ser Asn Arg Gly Thr Ile Pro Gln Ile Ile Asn Ser Pro Glu Thr Tyr           
        195                 200                 205                       

gat aac gtg ata gaa tta ctt aca gat gct aga att ttc ggt aac gat        672
Asp Asn Val Ile Glu Leu Leu Thr Asp Ala Arg Ile Phe Gly Asn Asp           
    210                 215                 220                           

gct cgt cgt tat ctg gaa ggg aac cgt aag ttg gaa cgt tct gct ccg        720
Ala Arg Arg Tyr Leu Glu Gly Asn Arg Lys Leu Glu Arg Ser Ala Pro           
225                 230                 235                 240           

att cca ctc acg att aat atg tat cgt aga act act ttg atc gga aac        768
Ile Pro Leu Thr Ile Asn Met Tyr Arg Arg Thr Thr Leu Ile Gly Asn           
                245                 250                 255               

gtg agt aat cgg tat tat ttc gga aag tta taa                            801
Val Ser Asn Arg Tyr Tyr Phe Gly Lys Leu                                   
            260                 265                                       


<210>  8
<211>  266
<212>  PRT
<213>  Leptospira interrogans serovar Pomona

<400>  8

Met Asn Leu Ser Lys His Thr Ala Val Leu Thr Gly Ile Val Phe Phe 
1               5                   10                  15      


Leu Ala Phe Ser Leu Ser Met Tyr Val Ser Val Ile Glu Lys Ala Gly 
            20                  25                  30          


Thr Lys Asp Glu Tyr Pro Tyr Thr Met Lys Ile Tyr Tyr Pro Arg Leu 
        35                  40                  45              


Glu Gly Ile His Pro Gly Ala Pro Val Arg Ile Leu Gly Val Glu Lys 
    50                  55                  60                  


Gly Ile Val Arg Ser Leu Asp Val Val Pro Ile Asp Glu Val Glu Asp 
65                  70                  75                  80  


Gln Arg Phe Leu Asn Lys Asp Gln Thr Lys Ala Ile Glu Ile Ile Val 
                85                  90                  95      


Arg Leu Lys Glu Pro Ile Thr Leu Trp Asp Asn Tyr Lys Ile Thr Phe 
            100                 105                 110         


Gln Thr Asn Thr Ile Leu Ser Gly Arg Thr Ile Asp Ile Asp Pro Gly 
        115                 120                 125             


Ser Phe Asp Lys Glu Glu Thr Ser Phe Phe Gln Pro Thr Tyr Leu Glu 
    130                 135                 140                 


Glu Glu Gln Lys Ser Pro Asp Phe Leu Pro Ser Ala Asp Tyr Phe Glu 
145                 150                 155                 160 


Asp Phe Phe Ala Ala Ser Thr Gly Val Ile Arg Glu Asn Arg Glu Asp 
                165                 170                 175     


Ile Arg Thr Ser Phe Asn Asn Phe Tyr Glu Ile Ser Glu Lys Leu Lys 
            180                 185                 190         


Ser Asn Arg Gly Thr Ile Pro Gln Ile Ile Asn Ser Pro Glu Thr Tyr 
        195                 200                 205             


Asp Asn Val Ile Glu Leu Leu Thr Asp Ala Arg Ile Phe Gly Asn Asp 
    210                 215                 220                 


Ala Arg Arg Tyr Leu Glu Gly Asn Arg Lys Leu Glu Arg Ser Ala Pro 
225                 230                 235                 240 


Ile Pro Leu Thr Ile Asn Met Tyr Arg Arg Thr Thr Leu Ile Gly Asn 
                245                 250                 255     


Val Ser Asn Arg Tyr Tyr Phe Gly Lys Leu 
            260                 265     


<210>  9
<211>  1263
<212>  DNA
<213>  Leptospira interrogans serovar Pomona


<220>
<221>  CDS
<222>  (1)..(1263)

<400>  9
atg ctc aac aca aaa ata aag aaa aaa tta ttt ctc tca gtt att ttt         48
Met Leu Asn Thr Lys Ile Lys Lys Lys Leu Phe Leu Ser Val Ile Phe           
1               5                   10                  15                

ttt cta ttt cta cca tcg gtc gcc tgt gcg gaa aaa agt ttt cgt aaa         96
Phe Leu Phe Leu Pro Ser Val Ala Cys Ala Glu Lys Ser Phe Arg Lys           
            20                  25                  30                    

cat atc gcg gac tca aaa ctc att cct tcc gaa atc gaa ttt tat tct        144
His Ile Ala Asp Ser Lys Leu Ile Pro Ser Glu Ile Glu Phe Tyr Ser           
        35                  40                  45                        

aac att ctt ccc gga ctt tcc gga aaa aat gtc att cta att aca aac        192
Asn Ile Leu Pro Gly Leu Ser Gly Lys Asn Val Ile Leu Ile Thr Asn           
    50                  55                  60                            

cca tct gga atc gga aga agc ccc gaa agg att tta cga gaa ttt aaa        240
Pro Ser Gly Ile Gly Arg Ser Pro Glu Arg Ile Leu Arg Glu Phe Lys           
65                  70                  75                  80            

aaa cac gac gta aaa atc aaa cat ctc atc gga ttg gaa cac gga ttt        288
Lys His Asp Val Lys Ile Lys His Leu Ile Gly Leu Glu His Gly Phe           
                85                  90                  95                

tta gga ctc gag gag gac ttc agt aaa tct ccc gtt acg gtg gat gaa        336
Leu Gly Leu Glu Glu Asp Phe Ser Lys Ser Pro Val Thr Val Asp Glu           
            100                 105                 110                   

ttt ttt aat ctc cca atc tat cat atc tat cga gtc aag aac gca gaa        384
Phe Phe Asn Leu Pro Ile Tyr His Ile Tyr Arg Val Lys Asn Ala Glu           
        115                 120                 125                       

ctt cct acg att ttg aaa gga gcc gac gcg att ctt ttt gat gtg caa        432
Leu Pro Thr Ile Leu Lys Gly Ala Asp Ala Ile Leu Phe Asp Val Gln           
    130                 135                 140                           

gat atg ggg atg aga tgt tat act tat cta acc gtt tta aaa aga att        480
Asp Met Gly Met Arg Cys Tyr Thr Tyr Leu Thr Val Leu Lys Arg Ile           
145                 150                 155                 160           

atg gat gga att cca gat cct aca aat acg aga ctg atc gtt ttg gat        528
Met Asp Gly Ile Pro Asp Pro Thr Asn Thr Arg Leu Ile Val Leu Asp           
                165                 170                 175               

cac gta aac ccc gct ctt tat tta aaa gga aga gga gaa atg atc gat        576
His Val Asn Pro Ala Leu Tyr Leu Lys Gly Arg Gly Glu Met Ile Asp           
            180                 185                 190                   

aaa cgt ttc tta aat ttt gca gga gaa ttc cct tct ctt ttt ttt gga        624
Lys Arg Phe Leu Asn Phe Ala Gly Glu Phe Pro Ser Leu Phe Phe Gly           
        195                 200                 205                       

ggt ttg acc ttg gga gaa tca gcg gtt tat tat aac tct gaa tat tta        672
Gly Leu Thr Leu Gly Glu Ser Ala Val Tyr Tyr Asn Ser Glu Tyr Leu           
    210                 215                 220                           

gat aaa aag gtt cgt tta gaa gtg gta tct cct aaa aac gca aaa cga        720
Asp Lys Lys Val Arg Leu Glu Val Val Ser Pro Lys Asn Ala Lys Arg           
225                 230                 235                 240           

tct ttt gat tgg gat aga gaa gga att cct tgg act aca cct tct cct        768
Ser Phe Asp Trp Asp Arg Glu Gly Ile Pro Trp Thr Thr Pro Ser Pro           
                245                 250                 255               

aat tta cca act ata gat tct gcg atc aat tat ctg ggg ctt gtt ttg        816
Asn Leu Pro Thr Ile Asp Ser Ala Ile Asn Tyr Leu Gly Leu Val Leu           
            260                 265                 270                   

tta gaa gga gtg aac gtt tct gtg gga agg ggt aca acc gca cct ttt        864
Leu Glu Gly Val Asn Val Ser Val Gly Arg Gly Thr Thr Ala Pro Phe           
        275                 280                 285                       

gta tat ttc gga gcg cct tgg atg aca gag ccc gaa aag tta gcg gaa        912
Val Tyr Phe Gly Ala Pro Trp Met Thr Glu Pro Glu Lys Leu Ala Glu           
    290                 295                 300                           

gaa tta aat caa aat tca ggt gga gaa tat tat tat cag act gtg ttt        960
Glu Leu Asn Gln Asn Ser Gly Gly Glu Tyr Tyr Tyr Gln Thr Val Phe           
305                 310                 315                 320           

ttt aaa cct gta ttt ggt cct tac aag aat gag att tgt aga gga ttg       1008
Phe Lys Pro Val Phe Gly Pro Tyr Lys Asn Glu Ile Cys Arg Gly Leu           
                325                 330                 335               

cgc cta acg gta gta aat cga aag tat gat cct tta aaa atg gca ttc       1056
Arg Leu Thr Val Val Asn Arg Lys Tyr Asp Pro Leu Lys Met Ala Phe           
            340                 345                 350                   

cag ttg atc tcc gct tta aaa tcg aat tat aaa gaa ttt aaa tgg aga       1104
Gln Leu Ile Ser Ala Leu Lys Ser Asn Tyr Lys Glu Phe Lys Trp Arg           
        355                 360                 365                       

tcg tat ccg gat gga acc tac aat ata gat ttc cta tgg gga acg gaa       1152
Ser Tyr Pro Asp Gly Thr Tyr Asn Ile Asp Phe Leu Trp Gly Thr Glu           
    370                 375                 380                           

tcg ttt cga aaa acg atc gac gcc gga aaa aaa tac gat caa tat gcg       1200
Ser Phe Arg Lys Thr Ile Asp Ala Gly Lys Lys Tyr Asp Gln Tyr Ala           
385                 390                 395                 400           

gaa tac tta agt tcc att gag aaa gaa tat aat gaa aaa att aag aaa       1248
Glu Tyr Leu Ser Ser Ile Glu Lys Glu Tyr Asn Glu Lys Ile Lys Lys           
                405                 410                 415               

tat tat ctc tac tga                                                   1263
Tyr Tyr Leu Tyr                                                           
            420                                                           


<210>  10
<211>  420
<212>  PRT
<213>  Leptospira interrogans serovar Pomona

<400>  10

Met Leu Asn Thr Lys Ile Lys Lys Lys Leu Phe Leu Ser Val Ile Phe 
1               5                   10                  15      


Phe Leu Phe Leu Pro Ser Val Ala Cys Ala Glu Lys Ser Phe Arg Lys 
            20                  25                  30          


His Ile Ala Asp Ser Lys Leu Ile Pro Ser Glu Ile Glu Phe Tyr Ser 
        35                  40                  45              


Asn Ile Leu Pro Gly Leu Ser Gly Lys Asn Val Ile Leu Ile Thr Asn 
    50                  55                  60                  


Pro Ser Gly Ile Gly Arg Ser Pro Glu Arg Ile Leu Arg Glu Phe Lys 
65                  70                  75                  80  


Lys His Asp Val Lys Ile Lys His Leu Ile Gly Leu Glu His Gly Phe 
                85                  90                  95      


Leu Gly Leu Glu Glu Asp Phe Ser Lys Ser Pro Val Thr Val Asp Glu 
            100                 105                 110         


Phe Phe Asn Leu Pro Ile Tyr His Ile Tyr Arg Val Lys Asn Ala Glu 
        115                 120                 125             


Leu Pro Thr Ile Leu Lys Gly Ala Asp Ala Ile Leu Phe Asp Val Gln 
    130                 135                 140                 


Asp Met Gly Met Arg Cys Tyr Thr Tyr Leu Thr Val Leu Lys Arg Ile 
145                 150                 155                 160 


Met Asp Gly Ile Pro Asp Pro Thr Asn Thr Arg Leu Ile Val Leu Asp 
                165                 170                 175     


His Val Asn Pro Ala Leu Tyr Leu Lys Gly Arg Gly Glu Met Ile Asp 
            180                 185                 190         


Lys Arg Phe Leu Asn Phe Ala Gly Glu Phe Pro Ser Leu Phe Phe Gly 
        195                 200                 205             


Gly Leu Thr Leu Gly Glu Ser Ala Val Tyr Tyr Asn Ser Glu Tyr Leu 
    210                 215                 220                 


Asp Lys Lys Val Arg Leu Glu Val Val Ser Pro Lys Asn Ala Lys Arg 
225                 230                 235                 240 


Ser Phe Asp Trp Asp Arg Glu Gly Ile Pro Trp Thr Thr Pro Ser Pro 
                245                 250                 255     


Asn Leu Pro Thr Ile Asp Ser Ala Ile Asn Tyr Leu Gly Leu Val Leu 
            260                 265                 270         


Leu Glu Gly Val Asn Val Ser Val Gly Arg Gly Thr Thr Ala Pro Phe 
        275                 280                 285             


Val Tyr Phe Gly Ala Pro Trp Met Thr Glu Pro Glu Lys Leu Ala Glu 
    290                 295                 300                 


Glu Leu Asn Gln Asn Ser Gly Gly Glu Tyr Tyr Tyr Gln Thr Val Phe 
305                 310                 315                 320 


Phe Lys Pro Val Phe Gly Pro Tyr Lys Asn Glu Ile Cys Arg Gly Leu 
                325                 330                 335     


Arg Leu Thr Val Val Asn Arg Lys Tyr Asp Pro Leu Lys Met Ala Phe 
            340                 345                 350         


Gln Leu Ile Ser Ala Leu Lys Ser Asn Tyr Lys Glu Phe Lys Trp Arg 
        355                 360                 365             


Ser Tyr Pro Asp Gly Thr Tyr Asn Ile Asp Phe Leu Trp Gly Thr Glu 
    370                 375                 380                 


Ser Phe Arg Lys Thr Ile Asp Ala Gly Lys Lys Tyr Asp Gln Tyr Ala 
385                 390                 395                 400 


Glu Tyr Leu Ser Ser Ile Glu Lys Glu Tyr Asn Glu Lys Ile Lys Lys 
                405                 410                 415     


Tyr Tyr Leu Tyr 
            420 


<210>  11
<211>  266
<212>  PRT
<213>  Leptospira interrogans serovar Lai

<300>
<308>  GenBank / AAN47806
<309>  2006-02-01
<313>  (1)..(266)

<400>  11

Met Asn Leu Ser Lys His Thr Ala Val Leu Thr Gly Ile Val Phe Phe 
1               5                   10                  15      


Leu Ala Phe Ser Leu Ser Met Tyr Val Ser Val Ile Glu Lys Ala Gly 
            20                  25                  30          


Thr Lys Asp Glu Tyr Pro Tyr Thr Met Lys Ile Tyr Tyr Pro Arg Leu 
        35                  40                  45              


Glu Gly Ile His Pro Gly Ala Pro Val Arg Ile Leu Gly Val Glu Lys 
    50                  55                  60                  


Gly Ile Val Arg Ser Leu Asp Val Val Pro Ile Asp Glu Val Glu Asp 
65                  70                  75                  80  


Gln Arg Phe Leu Asn Lys Asp Gln Thr Lys Ala Ile Glu Ile Ile Val 
                85                  90                  95      


Arg Leu Lys Glu Pro Ile Thr Leu Trp Asp Asn Tyr Lys Ile Thr Phe 
            100                 105                 110         


Gln Thr Asn Thr Ile Leu Ser Gly Arg Thr Ile Asp Ile Asp Pro Gly 
        115                 120                 125             


Ser Phe Asp Lys Glu Glu Thr Ser Phe Phe Gln Pro Thr Tyr Leu Glu 
    130                 135                 140                 


Glu Glu Gln Lys Ser Pro Asp Phe Leu Pro Ser Ala Asp Tyr Phe Glu 
145                 150                 155                 160 


Asp Phe Phe Ala Ala Ser Thr Gly Val Ile Arg Glu Asn Arg Glu Asp 
                165                 170                 175     


Ile Arg Thr Ser Phe Asn Asn Phe Tyr Glu Ile Ser Glu Lys Leu Lys 
            180                 185                 190         


Ser Asn Arg Gly Thr Ile Pro Gln Ile Ile Asn Ser Pro Glu Thr Tyr 
        195                 200                 205             


Asp Asn Val Ile Glu Leu Leu Thr Asp Ala Arg Ile Phe Gly Asn Asp 
    210                 215                 220                 


Ala Arg Arg Tyr Leu Glu Gly Asn Arg Lys Leu Glu Arg Ser Ala Pro 
225                 230                 235                 240 


Ile Pro Leu Thr Ile Asn Met Tyr Arg Arg Thr Thr Leu Ile Gly Asn 
                245                 250                 255     


Val Ser Asn Arg Tyr Tyr Phe Gly Lys Leu 
            260                 265     


<210>  12
<211>  251
<212>  PRT
<213>  Leptospira interrogans serovar Lai

<300>
<308>  GenBank / AAN49254
<309>  2006-02-01
<313>  (1)..(251)

<400>  12

Met Asn Met Asn Ser Leu Arg Tyr Leu Leu Val Gly Ile Ile Phe Thr 
1               5                   10                  15      


Ala Ala Ile Thr Val Val Gly Tyr Phe Thr Ile Ile Thr Glu Gly Gly 
            20                  25                  30          


Pro Ile Lys Lys Lys Gly Glu Phe Met Lys Val Thr Phe Arg Asn Ala 
        35                  40                  45              


Glu Gly Ile Lys Val Gly Asn Lys Val Thr Val Gln Gly Val Pro Phe 
    50                  55                  60                  


Gly Tyr Val Ser Ala Ile Arg Leu Ile Gln Ile Asp Glu Asn Gly Thr 
65                  70                  75                  80  


Glu Val Gln Ser Gly Glu Met Gly Ile Gly Thr Arg Val Glu Ile Thr 
                85                  90                  95      


Met Leu Leu Arg Glu Lys Ile Ser Leu Tyr Asp Asn Tyr Asp Ile Ile 
            100                 105                 110         


Ile Lys Asn Glu Ser Leu Leu Thr Gly Arg Val Ile Ala Ile Asp Pro 
        115                 120                 125             


Gly Thr Ala Asp Leu Glu Pro Lys Gln Leu Lys Thr Arg Thr Thr Pro 
    130                 135                 140                 


Ile Thr Met Ile Asp Tyr Lys Thr Thr Gly Ser Leu Lys Gly Arg Val 
145                 150                 155                 160 


Leu Gln Asp Pro Leu Val Ser Leu Ser Glu Leu Ile Ser Glu Asn Arg 
                165                 170                 175     


Gly Asp Ile Arg Lys Thr Phe Ser Asn Ile Ala Asp Ile Thr Thr Lys 
            180                 185                 190         


Ile Asn Thr Gly Asp Gly Ser Leu Gly Arg Leu Ile Asn Asn Asp Asp 
        195                 200                 205             


Val His Lys Asn Val Asn Thr Val Leu Thr Asp Ala Gln Ile Val Leu 
    210                 215                 220                 


Arg Glu Leu Arg Glu Gly Leu Glu Asp Thr Arg Glu Gln Thr Pro Val 
225                 230                 235                 240 


Thr Ser Phe Ile Arg Ala Ala Leu Ser Ala Phe 
                245                 250     


<210>  13
<211>  1323
<212>  DNA
<213>  Mycobacterium tuberculosis CDC1551


<220>
<221>  CDS
<222>  (1)..(1323)

<300>
<308>  GenBank / AE000516
<309>  2004-08-04
<313>  (91)..(879)

<400>  13
gtg cga cgt cgt gct caa ggt caa cgg caa ggg cgg cca gcc ggt gta         48
Met Arg Arg Arg Ala Gln Gly Gln Arg Gln Gly Arg Pro Ala Gly Val           
1               5                   10                  15                

cat caa gct ggc cgg tca gga cag cgg gcg gtg cgc gcc gaa atg aaa         96
His Gln Ala Gly Arg Ser Gly Gln Arg Ala Val Arg Ala Glu Met Lys           
            20                  25                  30                    

tcc ttc gcc gaa cgc aac cgt ctg gcc atc ggc aca gtc ggc atc gtc        144
Ser Phe Ala Glu Arg Asn Arg Leu Ala Ile Gly Thr Val Gly Ile Val           
        35                  40                  45                        

gtc gtc gcc gcc gtt gcg ctg gcc gcg ctg caa tac cag cgg ctg ccg        192
Val Val Ala Ala Val Ala Leu Ala Ala Leu Gln Tyr Gln Arg Leu Pro           
    50                  55                  60                            

ttt ttc aac cag ggc acc agg gtc tcc gcc tat ttc gcc gac gcc ggc        240
Phe Phe Asn Gln Gly Thr Arg Val Ser Ala Tyr Phe Ala Asp Ala Gly           
65                  70                  75                  80            

ggg ctg cgc acc ggc aac acc gtc gag gtc tcc ggc tat ccg gtg gga        288
Gly Leu Arg Thr Gly Asn Thr Val Glu Val Ser Gly Tyr Pro Val Gly           
                85                  90                  95                

aag gtg tcc agc atc tcg ctc gac gga ccg ggc gtg ctg gtg gag ttc        336
Lys Val Ser Ser Ile Ser Leu Asp Gly Pro Gly Val Leu Val Glu Phe           
            100                 105                 110                   

aag gtc gac acc gac gtc cga ctc gga aac cgc acc gaa gtg gca atc        384
Lys Val Asp Thr Asp Val Arg Leu Gly Asn Arg Thr Glu Val Ala Ile           
        115                 120                 125                       

aaa acc aag ggc ttg ttg ggc agc aag ttc ctc gac gtc acc ccc cgc        432
Lys Thr Lys Gly Leu Leu Gly Ser Lys Phe Leu Asp Val Thr Pro Arg           
    130                 135                 140                           

ggg gac ggc cga ctc gat tct ccg atc ccg atc gag cgg acc acg tcg        480
Gly Asp Gly Arg Leu Asp Ser Pro Ile Pro Ile Glu Arg Thr Thr Ser           
145                 150                 155                 160           

ccc tac caa ctg ccc gac gcc ctt ggc gat ttg gcc gcc acg atc agc        528
Pro Tyr Gln Leu Pro Asp Ala Leu Gly Asp Leu Ala Ala Thr Ile Ser           
                165                 170                 175               

ggg ttg cac acc gag cgg ctg tcc gaa tcg ctg gcc acc ctg gcg cag        576
Gly Leu His Thr Glu Arg Leu Ser Glu Ser Leu Ala Thr Leu Ala Gln           
            180                 185                 190                   

acc ttt gcc gat acg ccg gcg cac ttc cgc aac gcc ata cac ggg gtg        624
Thr Phe Ala Asp Thr Pro Ala His Phe Arg Asn Ala Ile His Gly Val           
        195                 200                 205                       

gcc cgg ctc gcc caa acc ctc gat gag cgc gac aac caa ctg cgc agc        672
Ala Arg Leu Ala Gln Thr Leu Asp Glu Arg Asp Asn Gln Leu Arg Ser           
    210                 215                 220                           

ctg ctg gcc aac gcg gcc aaa gcc acc ggg gtg ctg gcc aac cgc acc        720
Leu Leu Ala Asn Ala Ala Lys Ala Thr Gly Val Leu Ala Asn Arg Thr           
225                 230                 235                 240           

gac cag atc gtc ggc ctg gtg cgc gac acg aat gtg gtc ttg gcg cag        768
Asp Gln Ile Val Gly Leu Val Arg Asp Thr Asn Val Val Leu Ala Gln           
                245                 250                 255               

ctg cgc acc caa agc gcc gcc ctg gac cgg atc tgg gcg aac atc tcg        816
Leu Arg Thr Gln Ser Ala Ala Leu Asp Arg Ile Trp Ala Asn Ile Ser           
            260                 265                 270                   

gcg gtg gcc gaa caa ctg cgg ggc ttc atc gct gag aac cgc cag cag        864
Ala Val Ala Glu Gln Leu Arg Gly Phe Ile Ala Glu Asn Arg Gln Gln           
        275                 280                 285                       

ctg cgc ccg gcg ctg gac aag ctc aac ggg gtg ctg gct atc gtc gaa        912
Leu Arg Pro Ala Leu Asp Lys Leu Asn Gly Val Leu Ala Ile Val Glu           
    290                 295                 300                           

aac cgc aaa gag cgt gtg cgg cag gcc atc ccg ctg atc aac acc tat        960
Asn Arg Lys Glu Arg Val Arg Gln Ala Ile Pro Leu Ile Asn Thr Tyr           
305                 310                 315                 320           

gtc atg tcg ctg ggt gag tcg ctg tcg tcg ggc ccg ttc ttc aag gca       1008
Val Met Ser Leu Gly Glu Ser Leu Ser Ser Gly Pro Phe Phe Lys Ala           
                325                 330                 335               

tac gtg gtg aac ctg ctg ccg ggt cag ttc gtg caa ccg ttc atc agc       1056
Tyr Val Val Asn Leu Leu Pro Gly Gln Phe Val Gln Pro Phe Ile Ser           
            340                 345                 350                   

gcc gcg ttc tcc gac ctg ggg ctc gac ccg gcc acg ttg ctg ccg tcg       1104
Ala Ala Phe Ser Asp Leu Gly Leu Asp Pro Ala Thr Leu Leu Pro Ser           
        355                 360                 365                       

cag ctg acc gac cca ccg acc ggt caa ccc gga acc ccg ccg ttg ccg       1152
Gln Leu Thr Asp Pro Pro Thr Gly Gln Pro Gly Thr Pro Pro Leu Pro           
    370                 375                 380                           

atg ccc tac ccg cgc acg ggc cag ggc ggt gag ccg cgg ctg acg ctg       1200
Met Pro Tyr Pro Arg Thr Gly Gln Gly Gly Glu Pro Arg Leu Thr Leu           
385                 390                 395                 400           

ccc gac gcg atc acc ggc aat ccc ggc gat ccg cgc tat ccg tac cgg       1248
Pro Asp Ala Ile Thr Gly Asn Pro Gly Asp Pro Arg Tyr Pro Tyr Arg           
                405                 410                 415               

ccg gag ccg ccc gcg ccg ccg ccc ggc ggg ccg ccg ccc ggc ccg ccc       1296
Pro Glu Pro Pro Ala Pro Pro Pro Gly Gly Pro Pro Pro Gly Pro Pro           
            420                 425                 430                   

gcg cag cag ccg gga gac caa ccg tga                                   1323
Ala Gln Gln Pro Gly Asp Gln Pro                                           
        435                 440                                           


<210>  14
<211>  440
<212>  PRT
<213>  Mycobacterium tuberculosis CDC1551

<400>  14

Met Arg Arg Arg Ala Gln Gly Gln Arg Gln Gly Arg Pro Ala Gly Val 
1               5                   10                  15      


His Gln Ala Gly Arg Ser Gly Gln Arg Ala Val Arg Ala Glu Met Lys 
            20                  25                  30          


Ser Phe Ala Glu Arg Asn Arg Leu Ala Ile Gly Thr Val Gly Ile Val 
        35                  40                  45              


Val Val Ala Ala Val Ala Leu Ala Ala Leu Gln Tyr Gln Arg Leu Pro 
    50                  55                  60                  


Phe Phe Asn Gln Gly Thr Arg Val Ser Ala Tyr Phe Ala Asp Ala Gly 
65                  70                  75                  80  


Gly Leu Arg Thr Gly Asn Thr Val Glu Val Ser Gly Tyr Pro Val Gly 
                85                  90                  95      


Lys Val Ser Ser Ile Ser Leu Asp Gly Pro Gly Val Leu Val Glu Phe 
            100                 105                 110         


Lys Val Asp Thr Asp Val Arg Leu Gly Asn Arg Thr Glu Val Ala Ile 
        115                 120                 125             


Lys Thr Lys Gly Leu Leu Gly Ser Lys Phe Leu Asp Val Thr Pro Arg 
    130                 135                 140                 


Gly Asp Gly Arg Leu Asp Ser Pro Ile Pro Ile Glu Arg Thr Thr Ser 
145                 150                 155                 160 


Pro Tyr Gln Leu Pro Asp Ala Leu Gly Asp Leu Ala Ala Thr Ile Ser 
                165                 170                 175     


Gly Leu His Thr Glu Arg Leu Ser Glu Ser Leu Ala Thr Leu Ala Gln 
            180                 185                 190         


Thr Phe Ala Asp Thr Pro Ala His Phe Arg Asn Ala Ile His Gly Val 
        195                 200                 205             


Ala Arg Leu Ala Gln Thr Leu Asp Glu Arg Asp Asn Gln Leu Arg Ser 
    210                 215                 220                 


Leu Leu Ala Asn Ala Ala Lys Ala Thr Gly Val Leu Ala Asn Arg Thr 
225                 230                 235                 240 


Asp Gln Ile Val Gly Leu Val Arg Asp Thr Asn Val Val Leu Ala Gln 
                245                 250                 255     


Leu Arg Thr Gln Ser Ala Ala Leu Asp Arg Ile Trp Ala Asn Ile Ser 
            260                 265                 270         


Ala Val Ala Glu Gln Leu Arg Gly Phe Ile Ala Glu Asn Arg Gln Gln 
        275                 280                 285             


Leu Arg Pro Ala Leu Asp Lys Leu Asn Gly Val Leu Ala Ile Val Glu 
    290                 295                 300                 


Asn Arg Lys Glu Arg Val Arg Gln Ala Ile Pro Leu Ile Asn Thr Tyr 
305                 310                 315                 320 


Val Met Ser Leu Gly Glu Ser Leu Ser Ser Gly Pro Phe Phe Lys Ala 
                325                 330                 335     


Tyr Val Val Asn Leu Leu Pro Gly Gln Phe Val Gln Pro Phe Ile Ser 
            340                 345                 350         


Ala Ala Phe Ser Asp Leu Gly Leu Asp Pro Ala Thr Leu Leu Pro Ser 
        355                 360                 365             


Gln Leu Thr Asp Pro Pro Thr Gly Gln Pro Gly Thr Pro Pro Leu Pro 
    370                 375                 380                 


Met Pro Tyr Pro Arg Thr Gly Gln Gly Gly Glu Pro Arg Leu Thr Leu 
385                 390                 395                 400 


Pro Asp Ala Ile Thr Gly Asn Pro Gly Asp Pro Arg Tyr Pro Tyr Arg 
                405                 410                 415     


Pro Glu Pro Pro Ala Pro Pro Pro Gly Gly Pro Pro Pro Gly Pro Pro 
            420                 425                 430         


Ala Gln Gln Pro Gly Asp Gln Pro 
        435                 440 


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-1beta nonapeptide

<400>  15

Val Gln Gly Glu Glu Ser Asn Asp Lys 
1               5                   


<210>  16
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  16
cgcggatcca cgttaggcaa ct                                                22


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  17
ccgctcgagt tagttttgtt t                                                 21


<210>  18
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  18
cgcggatcca atccgataac gaat                                              24


<210>  19
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  19
ccgctcgagt taatgatatt cgtttt                                            26


<210>  20
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  20
cgcggatcca gagttccttt tttt                                              24


<210>  21
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  21
ccgctcgagt taaggaacgt tt                                                22


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  22
tttggatccg cgattaccgt a                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  23
cttctcgagt taaaagcact t                                                 21


<210>  24
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  24
cgcggatccc ccgacttaaa tgt                                               23


<210>  25
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  25
ccgctcgagt caaagtatcg aat                                               23


<210>  26
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  26
cgcggatccg tcaataacaa cattgc                                            26


<210>  27
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  27
ccgctcgagt tggtttcctt ttacgtt                                           27


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  28
cgcggatcca tgttgttaca c                                                 21


<210>  29
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  29
ccgctcgagc tactgagaaa tcttt                                             25


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  30
cgcggatcct ctcccgaatg g                                                 21


<210>  31
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  31
ccgctcgagt tatctcgtat caaa                                              24


<210>  32
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  32
cgcggatcca tagtacgttt aaaa                                              24


<210>  33
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  33
ccgctcgagt taaaaactgt ggga                                              24


<210>  34
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  34
cgcggatccc aatcaaaatc ggc                                               23


<210>  35
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  35
ccgctcgagt taatcctcta aatct                                             25


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  36
tcccccgggg ctggcaaaag a                                                 21


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  37
ccctcgagaa tatccgtatt aga                                               23


<210>  38
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  38
aggggaattc tatgaaaaac tttcgat                                           27


<210>  39
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  39
ccctcgagct tagtcgcgtc ag                                                22


<210>  40
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  40
cgcggatccg atcagatcaa ctt                                               23


<210>  41
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  41
ccgctcgagt taattttgtg ttttt                                             25


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  42
cgcggatcct gcaaacaaga t                                                 21


<210>  43
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  43
cgcctcgagt tattgagaag cgtat                                             25


<210>  44
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  44
cgcggatccg aaaaagccgg aa                                                22


<210>  45
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  45
ccgctcgagt tataactttc cgaaat                                            26


<210>  46
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  46
cgcggatcct ttccagaaat ttct                                              24


<210>  47
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  47
ccgctcgagt taataatatc tttgt                                             25


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  48
cgcggatcca ttgcacaaat c                                                 21


<210>  49
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  49
ccgctcgagt caaagagcaa actt                                              24


<210>  50
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  50
cgcggatccg aagaaagatc ct                                                22


<210>  51
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  51
ccgctcgagt catcttttat cttt                                              24


<210>  52
<211>  2064
<212>  DNA
<213>  Leptospira interrogans serovar Pomona


<220>
<221>  CDS
<222>  (1)..(2064)

<400>  52
atg cgt cct ttt tct aaa tta att ttt att ctg gcc ttt tgt att ttt         48
Met Arg Pro Phe Ser Lys Leu Ile Phe Ile Leu Ala Phe Cys Ile Phe           
1               5                   10                  15                

ttg ccc gtt ttc tct caa cct cta ccg gac ctt ccg gaa aaa caa ttt         96
Leu Pro Val Phe Ser Gln Pro Leu Pro Asp Leu Pro Glu Lys Gln Phe           
            20                  25                  30                    

ggt caa cct ctt aat aca caa aac gac gaa tac aat cct ata gta agc        144
Gly Gln Pro Leu Asn Thr Gln Asn Asp Glu Tyr Asn Pro Ile Val Ser           
        35                  40                  45                        

cca gat gga aga tac atc gta ttc cag tcc aac cgt cca ggc gga gaa        192
Pro Asp Gly Arg Tyr Ile Val Phe Gln Ser Asn Arg Pro Gly Gly Glu           
    50                  55                  60                            

gga gga atg gac att tgg att tcc gag aac att cgc ttt tta gat aag        240
Gly Gly Met Asp Ile Trp Ile Ser Glu Asn Ile Arg Phe Leu Asp Lys           
65                  70                  75                  80            

gag ata cca gca gaa tgg act aaa ccc gta aat atg aat caa aat att        288
Glu Ile Pro Ala Glu Trp Thr Lys Pro Val Asn Met Asn Gln Asn Ile           
                85                  90                  95                

tgg gaa gaa tta aaa cgt cca cca gct gct gga gtt cgt aaa cca aat        336
Trp Glu Glu Leu Lys Arg Pro Pro Ala Ala Gly Val Arg Lys Pro Asn           
            100                 105                 110                   

cta ttc aac tct aac gcg ttt gaa ggt gga att tca att ctt ttc gat        384
Leu Phe Asn Ser Asn Ala Phe Glu Gly Gly Ile Ser Ile Leu Phe Asp           
        115                 120                 125                       

tct aac aac gcg cct tcg gaa att tat ttt act tct aca att aac ctt        432
Ser Asn Asn Ala Pro Ser Glu Ile Tyr Phe Thr Ser Thr Ile Asn Leu           
    130                 135                 140                           

gct gtt ggg cgt tcc ggt ttt gaa ggt ttg aat att tat aga aca att        480
Ala Val Gly Arg Ser Gly Phe Glu Gly Leu Asn Ile Tyr Arg Thr Ile           
145                 150                 155                 160           

aaa gat aaa aaa aca gga aga tgg aca gac cca gaa cat ctc agt gaa        528
Lys Asp Lys Lys Thr Gly Arg Trp Thr Asp Pro Glu His Leu Ser Glu           
                165                 170                 175               

att aat tcc aac ttc aat gat aag atg ccc gca att tct ccc gat gga        576
Ile Asn Ser Asn Phe Asn Asp Lys Met Pro Ala Ile Ser Pro Asp Gly           
            180                 185                 190                   

aat ttt ttg atc ttc tct tcg gac cgt ccg ggg ggt tac ggt gat ttc        624
Asn Phe Leu Ile Phe Ser Ser Asp Arg Pro Gly Gly Tyr Gly Asp Phe           
        195                 200                 205                       

gat ctt tgg atc tcg gtt cgt aat cca aaa aac gga agt tgg tcc caa        672
Asp Leu Trp Ile Ser Val Arg Asn Pro Lys Asn Gly Ser Trp Ser Gln           
    210                 215                 220                           

cct aaa aat tta ggt tct ccc ctc aac tct tcc gaa agt gaa att ctt        720
Pro Lys Asn Leu Gly Ser Pro Leu Asn Ser Ser Glu Ser Glu Ile Leu           
225                 230                 235                 240           

cct ttc att cat caa gac gga gaa caa ctt tat ttc agt tct aat cga        768
Pro Phe Ile His Gln Asp Gly Glu Gln Leu Tyr Phe Ser Ser Asn Arg           
                245                 250                 255               

gaa gac gaa aga aaa aaa ttt aag att ttt aga ata ttc tta aaa tat        816
Glu Asp Glu Arg Lys Lys Phe Lys Ile Phe Arg Ile Phe Leu Lys Tyr           
            260                 265                 270                   

aaa tct gct cta gac aac atg tta gaa gac gaa gaa gaa acc gaa gaa        864
Lys Ser Ala Leu Asp Asn Met Leu Glu Asp Glu Glu Glu Thr Glu Glu           
        275                 280                 285                       

act cct aca acc aaa ccg act gaa att tta att cct aaa att gat caa        912
Thr Pro Thr Thr Lys Pro Thr Glu Ile Leu Ile Pro Lys Ile Asp Gln           
    290                 295                 300                           

tct tct tta tta ctt ctt ccc aaa ccg ttt aac act gat aag tgg gaa        960
Ser Ser Leu Leu Leu Leu Pro Lys Pro Phe Asn Thr Asp Lys Trp Glu           
305                 310                 315                 320           

ggt ttt gat aac gaa gga atc agt ttt gac aaa gac ggt atc tgg gct       1008
Gly Phe Asp Asn Glu Gly Ile Ser Phe Asp Lys Asp Gly Ile Trp Ala           
                325                 330                 335               

tat att tct tcc aat cgt tct ggt gga gaa ggt caa ttt gac att ttc       1056
Tyr Ile Ser Ser Asn Arg Ser Gly Gly Glu Gly Gln Phe Asp Ile Phe           
            340                 345                 350                   

cgc ttt caa gtt ccg gaa tct att cgc aac tcc tat act tta aac ttc       1104
Arg Phe Gln Val Pro Glu Ser Ile Arg Asn Ser Tyr Thr Leu Asn Phe           
        355                 360                 365                       

aaa ggt cta gtt ttg gat ggt tcc gaa aag acg atg att gga tta gat       1152
Lys Gly Leu Val Leu Asp Gly Ser Glu Lys Thr Met Ile Gly Leu Asp           
    370                 375                 380                           

tct act tta aaa att tat gat gga act aaa ccg gct aac gta atc act       1200
Ser Thr Leu Lys Ile Tyr Asp Gly Thr Lys Pro Ala Asn Val Ile Thr           
385                 390                 395                 400           

tcg aaa aga atc gga gga gat ctt acc aaa gga aaa cct tct aat ttt       1248
Ser Lys Arg Ile Gly Gly Asp Leu Thr Lys Gly Lys Pro Ser Asn Phe           
                405                 410                 415               

gca aca act ctt caa acc gga aag gtt tat aaa ata gaa att agt tct       1296
Ala Thr Thr Leu Gln Thr Gly Lys Val Tyr Lys Ile Glu Ile Ser Ser           
            420                 425                 430                   

cct ggc ttt cat cct caa gag gat att ttg gat tta aga gga aac ata       1344
Pro Gly Phe His Pro Gln Glu Asp Ile Leu Asp Leu Arg Gly Asn Ile           
        435                 440                 445                       

ggt aaa aat cga aaa gtt tat aga acc tac gtt ctt tta cca att caa       1392
Gly Lys Asn Arg Lys Val Tyr Arg Thr Tyr Val Leu Leu Pro Ile Gln           
    450                 455                 460                           

gtt gaa gaa ggt aaa acg gaa gaa aca aaa ata gaa caa ccc ata gag       1440
Val Glu Glu Gly Lys Thr Glu Glu Thr Lys Ile Glu Gln Pro Ile Glu           
465                 470                 475                 480           

aat caa aaa cca aat tct gcc gcg ttg aaa gtc atc gta gca gac gca       1488
Asn Gln Lys Pro Asn Ser Ala Ala Leu Lys Val Ile Val Ala Asp Ala           
                485                 490                 495               

tct aca aaa caa atc ata cca gac gct aaa gtt act ctt ttt aca cct       1536
Ser Thr Lys Gln Ile Ile Pro Asp Ala Lys Val Thr Leu Phe Thr Pro           
            500                 505                 510                   

atg aac cgc aaa gga gaa tct ctt gtc caa gat gcg gat aaa aaa tct       1584
Met Asn Arg Lys Gly Glu Ser Leu Val Gln Asp Ala Asp Lys Lys Ser           
        515                 520                 525                       

ttt ctt att aaa aaa tta cca gat aac gat ttt gaa tta ttt gca aca       1632
Phe Leu Ile Lys Lys Leu Pro Asp Asn Asp Phe Glu Leu Phe Ala Thr           
    530                 535                 540                           

gct tcg aaa tat att tct gaa agt atc aat att att caa aaa aat att       1680
Ala Ser Lys Tyr Ile Ser Glu Ser Ile Asn Ile Ile Gln Lys Asn Ile           
545                 550                 555                 560           

tcc aaa aat gga act gta aca att tat ctg aaa gca gaa agc gac gta       1728
Ser Lys Asn Gly Thr Val Thr Ile Tyr Leu Lys Ala Glu Ser Asp Val           
                565                 570                 575               

gat ccg gtt tat aat cta cga gtt tat ttc gaa ttt aat aaa aca aaa       1776
Asp Pro Val Tyr Asn Leu Arg Val Tyr Phe Glu Phe Asn Lys Thr Lys           
            580                 585                 590                   

atc aca gaa gag aat aaa aag ttg cta gat cct ctt gta ggc tat ctt       1824
Ile Thr Glu Glu Asn Lys Lys Leu Leu Asp Pro Leu Val Gly Tyr Leu           
        595                 600                 605                       

ttg aaa aat gcg tcc gat aaa att gaa att ggg gga cat acc gac aac       1872
Leu Lys Asn Ala Ser Asp Lys Ile Glu Ile Gly Gly His Thr Asp Asn           
    610                 615                 620                           

gta gcc tct aag gaa tat aac aca aga ttg agt gcc aaa aga gcc cgt       1920
Val Ala Ser Lys Glu Tyr Asn Thr Arg Leu Ser Ala Lys Arg Ala Arg           
625                 630                 635                 640           

aac gtt tac gag tat ctt ctt tca aaa gga att ccg gag aaa aga atg       1968
Asn Val Tyr Glu Tyr Leu Leu Ser Lys Gly Ile Pro Glu Lys Arg Met           
                645                 650                 655               

aga atc agg gct tat tgg tat tca caa ccg gat gca gac aat gag aca       2016
Arg Ile Arg Ala Tyr Trp Tyr Ser Gln Pro Asp Ala Asp Asn Glu Thr           
            660                 665                 670                   

gaa acc gga aga gca aaa aat aga aga gtt ggt ttt aga aag ctc tga       2064
Glu Thr Gly Arg Ala Lys Asn Arg Arg Val Gly Phe Arg Lys Leu               
        675                 680                 685                       


<210>  53
<211>  687
<212>  PRT
<213>  Leptospira interrogans serovar Pomona

<400>  53

Met Arg Pro Phe Ser Lys Leu Ile Phe Ile Leu Ala Phe Cys Ile Phe 
1               5                   10                  15      


Leu Pro Val Phe Ser Gln Pro Leu Pro Asp Leu Pro Glu Lys Gln Phe 
            20                  25                  30          


Gly Gln Pro Leu Asn Thr Gln Asn Asp Glu Tyr Asn Pro Ile Val Ser 
        35                  40                  45              


Pro Asp Gly Arg Tyr Ile Val Phe Gln Ser Asn Arg Pro Gly Gly Glu 
    50                  55                  60                  


Gly Gly Met Asp Ile Trp Ile Ser Glu Asn Ile Arg Phe Leu Asp Lys 
65                  70                  75                  80  


Glu Ile Pro Ala Glu Trp Thr Lys Pro Val Asn Met Asn Gln Asn Ile 
                85                  90                  95      


Trp Glu Glu Leu Lys Arg Pro Pro Ala Ala Gly Val Arg Lys Pro Asn 
            100                 105                 110         


Leu Phe Asn Ser Asn Ala Phe Glu Gly Gly Ile Ser Ile Leu Phe Asp 
        115                 120                 125             


Ser Asn Asn Ala Pro Ser Glu Ile Tyr Phe Thr Ser Thr Ile Asn Leu 
    130                 135                 140                 


Ala Val Gly Arg Ser Gly Phe Glu Gly Leu Asn Ile Tyr Arg Thr Ile 
145                 150                 155                 160 


Lys Asp Lys Lys Thr Gly Arg Trp Thr Asp Pro Glu His Leu Ser Glu 
                165                 170                 175     


Ile Asn Ser Asn Phe Asn Asp Lys Met Pro Ala Ile Ser Pro Asp Gly 
            180                 185                 190         


Asn Phe Leu Ile Phe Ser Ser Asp Arg Pro Gly Gly Tyr Gly Asp Phe 
        195                 200                 205             


Asp Leu Trp Ile Ser Val Arg Asn Pro Lys Asn Gly Ser Trp Ser Gln 
    210                 215                 220                 


Pro Lys Asn Leu Gly Ser Pro Leu Asn Ser Ser Glu Ser Glu Ile Leu 
225                 230                 235                 240 


Pro Phe Ile His Gln Asp Gly Glu Gln Leu Tyr Phe Ser Ser Asn Arg 
                245                 250                 255     


Glu Asp Glu Arg Lys Lys Phe Lys Ile Phe Arg Ile Phe Leu Lys Tyr 
            260                 265                 270         


Lys Ser Ala Leu Asp Asn Met Leu Glu Asp Glu Glu Glu Thr Glu Glu 
        275                 280                 285             


Thr Pro Thr Thr Lys Pro Thr Glu Ile Leu Ile Pro Lys Ile Asp Gln 
    290                 295                 300                 


Ser Ser Leu Leu Leu Leu Pro Lys Pro Phe Asn Thr Asp Lys Trp Glu 
305                 310                 315                 320 


Gly Phe Asp Asn Glu Gly Ile Ser Phe Asp Lys Asp Gly Ile Trp Ala 
                325                 330                 335     


Tyr Ile Ser Ser Asn Arg Ser Gly Gly Glu Gly Gln Phe Asp Ile Phe 
            340                 345                 350         


Arg Phe Gln Val Pro Glu Ser Ile Arg Asn Ser Tyr Thr Leu Asn Phe 
        355                 360                 365             


Lys Gly Leu Val Leu Asp Gly Ser Glu Lys Thr Met Ile Gly Leu Asp 
    370                 375                 380                 


Ser Thr Leu Lys Ile Tyr Asp Gly Thr Lys Pro Ala Asn Val Ile Thr 
385                 390                 395                 400 


Ser Lys Arg Ile Gly Gly Asp Leu Thr Lys Gly Lys Pro Ser Asn Phe 
                405                 410                 415     


Ala Thr Thr Leu Gln Thr Gly Lys Val Tyr Lys Ile Glu Ile Ser Ser 
            420                 425                 430         


Pro Gly Phe His Pro Gln Glu Asp Ile Leu Asp Leu Arg Gly Asn Ile 
        435                 440                 445             


Gly Lys Asn Arg Lys Val Tyr Arg Thr Tyr Val Leu Leu Pro Ile Gln 
    450                 455                 460                 


Val Glu Glu Gly Lys Thr Glu Glu Thr Lys Ile Glu Gln Pro Ile Glu 
465                 470                 475                 480 


Asn Gln Lys Pro Asn Ser Ala Ala Leu Lys Val Ile Val Ala Asp Ala 
                485                 490                 495     


Ser Thr Lys Gln Ile Ile Pro Asp Ala Lys Val Thr Leu Phe Thr Pro 
            500                 505                 510         


Met Asn Arg Lys Gly Glu Ser Leu Val Gln Asp Ala Asp Lys Lys Ser 
        515                 520                 525             


Phe Leu Ile Lys Lys Leu Pro Asp Asn Asp Phe Glu Leu Phe Ala Thr 
    530                 535                 540                 


Ala Ser Lys Tyr Ile Ser Glu Ser Ile Asn Ile Ile Gln Lys Asn Ile 
545                 550                 555                 560 


Ser Lys Asn Gly Thr Val Thr Ile Tyr Leu Lys Ala Glu Ser Asp Val 
                565                 570                 575     


Asp Pro Val Tyr Asn Leu Arg Val Tyr Phe Glu Phe Asn Lys Thr Lys 
            580                 585                 590         


Ile Thr Glu Glu Asn Lys Lys Leu Leu Asp Pro Leu Val Gly Tyr Leu 
        595                 600                 605             


Leu Lys Asn Ala Ser Asp Lys Ile Glu Ile Gly Gly His Thr Asp Asn 
    610                 615                 620                 


Val Ala Ser Lys Glu Tyr Asn Thr Arg Leu Ser Ala Lys Arg Ala Arg 
625                 630                 635                 640 


Asn Val Tyr Glu Tyr Leu Leu Ser Lys Gly Ile Pro Glu Lys Arg Met 
                645                 650                 655     


Arg Ile Arg Ala Tyr Trp Tyr Ser Gln Pro Asp Ala Asp Asn Glu Thr 
            660                 665                 670         


Glu Thr Gly Arg Ala Lys Asn Arg Arg Val Gly Phe Arg Lys Leu 
        675                 680                 685         


<210>  54
<211>  1983
<212>  DNA
<213>  Leptospira interrogans serovar Pomona


<220>
<221>  CDS
<222>  (1)..(1983)

<400>  54
atg cat acc ctg ctg act ctg atc tta agc ctt ttg ctt ttc tct ggt         48
Met His Thr Leu Leu Thr Leu Ile Leu Ser Leu Leu Leu Phe Ser Gly           
1               5                   10                  15                

ctt cag tct gag aat aaa aat tct tcc tca aaa aaa cta agc gac tct         96
Leu Gln Ser Glu Asn Lys Asn Ser Ser Ser Lys Lys Leu Ser Asp Ser           
            20                  25                  30                    

gct tct tgg att cct aaa gaa aat ttt act caa ctc gca tca caa aga        144
Ala Ser Trp Ile Pro Lys Glu Asn Phe Thr Gln Leu Ala Ser Gln Arg           
        35                  40                  45                        

gaa aaa ttc aaa aac gtt tct cat aac gaa aca tta aaa cta gaa att        192
Glu Lys Phe Lys Asn Val Ser His Asn Glu Thr Leu Lys Leu Glu Ile           
    50                  55                  60                            

ggc tat aaa tta tta act gga aaa att ctt cag ttt gga aaa tta ctt        240
Gly Tyr Lys Leu Leu Thr Gly Lys Ile Leu Gln Phe Gly Lys Leu Leu           
65                  70                  75                  80            

agt acc gaa aac gca tac gtc ccc atc gaa tcc aac gaa att act tcc        288
Ser Thr Glu Asn Ala Tyr Val Pro Ile Glu Ser Asn Glu Ile Thr Ser           
                85                  90                  95                

gaa ctt tct caa ctc aac gac aag acc gta aga att tta tgc agt atg        336
Glu Leu Ser Gln Leu Asn Asp Lys Thr Val Arg Ile Leu Cys Ser Met           
            100                 105                 110                   

aaa ggt tcc acc tgc aat cct ata cgt tat gaa att tat ccc ttt tgg        384
Lys Gly Ser Thr Cys Asn Pro Ile Arg Tyr Glu Ile Tyr Pro Phe Trp           
        115                 120                 125                       

tat tcg aaa gaa atc aaa cct tgg acg atc aaa aaa att cct gat tac        432
Tyr Ser Lys Glu Ile Lys Pro Trp Thr Ile Lys Lys Ile Pro Asp Tyr           
    130                 135                 140                           

gta aat cat aat att ttt gca ttc aat cct aca gtt tcc cca gac ggt        480
Val Asn His Asn Ile Phe Ala Phe Asn Pro Thr Val Ser Pro Asp Gly           
145                 150                 155                 160           

aaa tat ctt ttt tgg acc gct tat gtc aaa cga ggt aaa tcc gga act        528
Lys Tyr Leu Phe Trp Thr Ala Tyr Val Lys Arg Gly Lys Ser Gly Thr           
                165                 170                 175               

caa aag att tgg tat tcc aaa tta gac gaa aaa ggt ttt tgg gaa gat        576
Gln Lys Ile Trp Tyr Ser Lys Leu Asp Glu Lys Gly Phe Trp Glu Asp           
            180                 185                 190                   

ggt aag gaa atg aac gct cct tta aat aat gaa atg cct tcc gct gtt        624
Gly Lys Glu Met Asn Ala Pro Leu Asn Asn Glu Met Pro Ser Ala Val           
        195                 200                 205                       

atc tct gca ctt cct ggt ggt aac gaa ctt ttc gtc ttt gga acg ttt        672
Ile Ser Ala Leu Pro Gly Gly Asn Glu Leu Phe Val Phe Gly Thr Phe           
    210                 215                 220                           

ggc gaa aaa gaa ctt tta gac gaa ctc agt aaa gat ttt gaa acg aag        720
Gly Glu Lys Glu Leu Leu Asp Glu Leu Ser Lys Asp Phe Glu Thr Lys           
225                 230                 235                 240           

gca gac ttg gcc gct cgt tct tct aaa aat tca aac gta tat aga aaa        768
Ala Asp Leu Ala Ala Arg Ser Ser Lys Asn Ser Asn Val Tyr Arg Lys           
                245                 250                 255               

aag ata gaa gaa ctt aga gca gaa tat gac gaa aaa acg aaa caa att        816
Lys Ile Glu Glu Leu Arg Ala Glu Tyr Asp Glu Lys Thr Lys Gln Ile           
            260                 265                 270                   

tca agc aga gtt cct ctt tat aaa agt ttt aag gaa aaa gat tcc tgg        864
Ser Ser Arg Val Pro Leu Tyr Lys Ser Phe Lys Glu Lys Asp Ser Trp           
        275                 280                 285                       

tct aaa cca agc ata tta aac ttt cct aat ttt tat aat ctt tat aga        912
Ser Lys Pro Ser Ile Leu Asn Phe Pro Asn Phe Tyr Asn Leu Tyr Arg           
    290                 295                 300                           

aag aga aac gat tca agc caa gaa att ttc ggt gga tct act ctt tct        960
Lys Arg Asn Asp Ser Ser Gln Glu Ile Phe Gly Gly Ser Thr Leu Ser           
305                 310                 315                 320           

tct tca ggg aga att tta atc tat tct tct caa cat aag gat tcc aaa       1008
Ser Ser Gly Arg Ile Leu Ile Tyr Ser Ser Gln His Lys Asp Ser Lys           
                325                 330                 335               

gga aaa ttg gat ctt tat gtt agc aaa atg tta aac gac gga acc ttt       1056
Gly Lys Leu Asp Leu Tyr Val Ser Lys Met Leu Asn Asp Gly Thr Phe           
            340                 345                 350                   

cct tta ggt aca aac tta gga gat gtg atc aac aca act cat gaa gag       1104
Pro Leu Gly Thr Asn Leu Gly Asp Val Ile Asn Thr Thr His Glu Glu           
        355                 360                 365                       

atg gct cct ttt tta gca agc gat gat aga acc ctt tat ttt tct agc       1152
Met Ala Pro Phe Leu Ala Ser Asp Asp Arg Thr Leu Tyr Phe Ser Ser           
    370                 375                 380                           

gac ggt cat aaa ggg ctc tct att tat atg aca aaa aga atc gga gaa       1200
Asp Gly His Lys Gly Leu Ser Ile Tyr Met Thr Lys Arg Ile Gly Glu           
385                 390                 395                 400           

ggt tgg gat caa tgg acc aaa cct gtc gag gtt tcc gaa aat cta aaa       1248
Gly Trp Asp Gln Trp Thr Lys Pro Val Glu Val Ser Glu Asn Leu Lys           
                405                 410                 415               

ggt gta aat ttt ttt tca att ccc gcg aat agc gac tgg gcc tat ata       1296
Gly Val Asn Phe Phe Ser Ile Pro Ala Asn Ser Asp Trp Ala Tyr Ile           
            420                 425                 430                   

agc aaa gac ggc cga ttg ttt atg gct tat ctt cct aaa gaa atg cgc       1344
Ser Lys Asp Gly Arg Leu Phe Met Ala Tyr Leu Pro Lys Glu Met Arg           
        435                 440                 445                       

cca gag aag gtc gtg atc ata aac gga aaa gtt tta gat acg gat ggt       1392
Pro Glu Lys Val Val Ile Ile Asn Gly Lys Val Leu Asp Thr Asp Gly           
    450                 455                 460                           

aac cct ctt tct gct gac ata cat tat gaa tct tta aag tct cac gaa       1440
Asn Pro Leu Ser Ala Asp Ile His Tyr Glu Ser Leu Lys Ser His Glu           
465                 470                 475                 480           

aag atc ggt agc gcc aaa agc gat cct tct aat ggt aat ttt tcg atc       1488
Lys Ile Gly Ser Ala Lys Ser Asp Pro Ser Asn Gly Asn Phe Ser Ile           
                485                 490                 495               

att ctc ccc ttc ggc gaa aac tac ggt ttt tac gcc cag aaa aaa ggt       1536
Ile Leu Pro Phe Gly Glu Asn Tyr Gly Phe Tyr Ala Gln Lys Lys Gly           
            500                 505                 510                   

tat ctt cca gta tca caa aat ttg aat cta agt tct aaa aag aaa ttc       1584
Tyr Leu Pro Val Ser Gln Asn Leu Asn Leu Ser Ser Lys Lys Lys Phe           
        515                 520                 525                       

tct gaa aaa gtg gaa gta att tta caa ctt cct ccg atc cga gaa aga       1632
Ser Glu Lys Val Glu Val Ile Leu Gln Leu Pro Pro Ile Arg Glu Arg           
    530                 535                 540                           

ggt tcc att caa atc aat aat tta ttt ttt gag tcc aag agt ttt caa       1680
Gly Ser Ile Gln Ile Asn Asn Leu Phe Phe Glu Ser Lys Ser Phe Gln           
545                 550                 555                 560           

atc gct ccg gaa tcc gcc cca gaa ctg gat cgt ctc gcg gaa atc gta       1728
Ile Ala Pro Glu Ser Ala Pro Glu Leu Asp Arg Leu Ala Glu Ile Val           
                565                 570                 575               

aag gaa aat cca gat att gaa att cag att gaa ggt cat acc gac aac       1776
Lys Glu Asn Pro Asp Ile Glu Ile Gln Ile Glu Gly His Thr Asp Asn           
            580                 585                 590                   

att ggc aag aaa aaa gac aat cta att ctt tcc gaa aaa aga gcg gca       1824
Ile Gly Lys Lys Lys Asp Asn Leu Ile Leu Ser Glu Lys Arg Ala Ala           
        595                 600                 605                       

gcg gtc gca gaa tat ctt ttt caa aaa cat tct att tct aag act aga       1872
Ala Val Ala Glu Tyr Leu Phe Gln Lys His Ser Ile Ser Lys Thr Arg           
    610                 615                 620                           

atc caa acc aaa ggt ttt ggg gac agt gtt cct ttg agt aaa aat gat       1920
Ile Gln Thr Lys Gly Phe Gly Asp Ser Val Pro Leu Ser Lys Asn Asp           
625                 630                 635                 640           

tcc gaa gaa gca cgc aaa aaa aac aga agg gtc aat ttt acg att ttg       1968
Ser Glu Glu Ala Arg Lys Lys Asn Arg Arg Val Asn Phe Thr Ile Leu           
                645                 650                 655               

aaa aaa agt aaa taa                                                   1983
Lys Lys Ser Lys                                                           
            660                                                           


<210>  55
<211>  660
<212>  PRT
<213>  Leptospira interrogans serovar Pomona

<400>  55

Met His Thr Leu Leu Thr Leu Ile Leu Ser Leu Leu Leu Phe Ser Gly 
1               5                   10                  15      


Leu Gln Ser Glu Asn Lys Asn Ser Ser Ser Lys Lys Leu Ser Asp Ser 
            20                  25                  30          


Ala Ser Trp Ile Pro Lys Glu Asn Phe Thr Gln Leu Ala Ser Gln Arg 
        35                  40                  45              


Glu Lys Phe Lys Asn Val Ser His Asn Glu Thr Leu Lys Leu Glu Ile 
    50                  55                  60                  


Gly Tyr Lys Leu Leu Thr Gly Lys Ile Leu Gln Phe Gly Lys Leu Leu 
65                  70                  75                  80  


Ser Thr Glu Asn Ala Tyr Val Pro Ile Glu Ser Asn Glu Ile Thr Ser 
                85                  90                  95      


Glu Leu Ser Gln Leu Asn Asp Lys Thr Val Arg Ile Leu Cys Ser Met 
            100                 105                 110         


Lys Gly Ser Thr Cys Asn Pro Ile Arg Tyr Glu Ile Tyr Pro Phe Trp 
        115                 120                 125             


Tyr Ser Lys Glu Ile Lys Pro Trp Thr Ile Lys Lys Ile Pro Asp Tyr 
    130                 135                 140                 


Val Asn His Asn Ile Phe Ala Phe Asn Pro Thr Val Ser Pro Asp Gly 
145                 150                 155                 160 


Lys Tyr Leu Phe Trp Thr Ala Tyr Val Lys Arg Gly Lys Ser Gly Thr 
                165                 170                 175     


Gln Lys Ile Trp Tyr Ser Lys Leu Asp Glu Lys Gly Phe Trp Glu Asp 
            180                 185                 190         


Gly Lys Glu Met Asn Ala Pro Leu Asn Asn Glu Met Pro Ser Ala Val 
        195                 200                 205             


Ile Ser Ala Leu Pro Gly Gly Asn Glu Leu Phe Val Phe Gly Thr Phe 
    210                 215                 220                 


Gly Glu Lys Glu Leu Leu Asp Glu Leu Ser Lys Asp Phe Glu Thr Lys 
225                 230                 235                 240 


Ala Asp Leu Ala Ala Arg Ser Ser Lys Asn Ser Asn Val Tyr Arg Lys 
                245                 250                 255     


Lys Ile Glu Glu Leu Arg Ala Glu Tyr Asp Glu Lys Thr Lys Gln Ile 
            260                 265                 270         


Ser Ser Arg Val Pro Leu Tyr Lys Ser Phe Lys Glu Lys Asp Ser Trp 
        275                 280                 285             


Ser Lys Pro Ser Ile Leu Asn Phe Pro Asn Phe Tyr Asn Leu Tyr Arg 
    290                 295                 300                 


Lys Arg Asn Asp Ser Ser Gln Glu Ile Phe Gly Gly Ser Thr Leu Ser 
305                 310                 315                 320 


Ser Ser Gly Arg Ile Leu Ile Tyr Ser Ser Gln His Lys Asp Ser Lys 
                325                 330                 335     


Gly Lys Leu Asp Leu Tyr Val Ser Lys Met Leu Asn Asp Gly Thr Phe 
            340                 345                 350         


Pro Leu Gly Thr Asn Leu Gly Asp Val Ile Asn Thr Thr His Glu Glu 
        355                 360                 365             


Met Ala Pro Phe Leu Ala Ser Asp Asp Arg Thr Leu Tyr Phe Ser Ser 
    370                 375                 380                 


Asp Gly His Lys Gly Leu Ser Ile Tyr Met Thr Lys Arg Ile Gly Glu 
385                 390                 395                 400 


Gly Trp Asp Gln Trp Thr Lys Pro Val Glu Val Ser Glu Asn Leu Lys 
                405                 410                 415     


Gly Val Asn Phe Phe Ser Ile Pro Ala Asn Ser Asp Trp Ala Tyr Ile 
            420                 425                 430         


Ser Lys Asp Gly Arg Leu Phe Met Ala Tyr Leu Pro Lys Glu Met Arg 
        435                 440                 445             


Pro Glu Lys Val Val Ile Ile Asn Gly Lys Val Leu Asp Thr Asp Gly 
    450                 455                 460                 


Asn Pro Leu Ser Ala Asp Ile His Tyr Glu Ser Leu Lys Ser His Glu 
465                 470                 475                 480 


Lys Ile Gly Ser Ala Lys Ser Asp Pro Ser Asn Gly Asn Phe Ser Ile 
                485                 490                 495     


Ile Leu Pro Phe Gly Glu Asn Tyr Gly Phe Tyr Ala Gln Lys Lys Gly 
            500                 505                 510         


Tyr Leu Pro Val Ser Gln Asn Leu Asn Leu Ser Ser Lys Lys Lys Phe 
        515                 520                 525             


Ser Glu Lys Val Glu Val Ile Leu Gln Leu Pro Pro Ile Arg Glu Arg 
    530                 535                 540                 


Gly Ser Ile Gln Ile Asn Asn Leu Phe Phe Glu Ser Lys Ser Phe Gln 
545                 550                 555                 560 


Ile Ala Pro Glu Ser Ala Pro Glu Leu Asp Arg Leu Ala Glu Ile Val 
                565                 570                 575     


Lys Glu Asn Pro Asp Ile Glu Ile Gln Ile Glu Gly His Thr Asp Asn 
            580                 585                 590         


Ile Gly Lys Lys Lys Asp Asn Leu Ile Leu Ser Glu Lys Arg Ala Ala 
        595                 600                 605             


Ala Val Ala Glu Tyr Leu Phe Gln Lys His Ser Ile Ser Lys Thr Arg 
    610                 615                 620                 


Ile Gln Thr Lys Gly Phe Gly Asp Ser Val Pro Leu Ser Lys Asn Asp 
625                 630                 635                 640 


Ser Glu Glu Ala Arg Lys Lys Asn Arg Arg Val Asn Phe Thr Ile Leu 
                645                 650                 655     


Lys Lys Ser Lys 
            660 


<210>  56
<211>  1428
<212>  DNA
<213>  Leptospira interrogans serovar Pomona


<220>
<221>  CDS
<222>  (1)..(1428)

<400>  56
ttg gaa agt ttt tta cac ttt cct tat gtt tta aag gaa tct tac gaa         48
Met Glu Ser Phe Leu His Phe Pro Tyr Val Leu Lys Glu Ser Tyr Glu           
1               5                   10                  15                

act aaa act atg ggg aaa ttt tcc aat caa cct tca aaa tcc aaa atc         96
Thr Lys Thr Met Gly Lys Phe Ser Asn Gln Pro Ser Lys Ser Lys Ile           
            20                  25                  30                    

ata aac aga cgt tta cga aga att gta tca tac gtt ttt att att tct        144
Ile Asn Arg Arg Leu Arg Arg Ile Val Ser Tyr Val Phe Ile Ile Ser           
        35                  40                  45                        

aca ttg atc ggt ttt act tct act ttt cca gaa gaa tcg gac aaa gtt        192
Thr Leu Ile Gly Phe Thr Ser Thr Phe Pro Glu Glu Ser Asp Lys Val           
    50                  55                  60                            

ctc ttt cgt tgg aaa cta aaa cca gga gag aat gta gaa tta aac gaa        240
Leu Phe Arg Trp Lys Leu Lys Pro Gly Glu Asn Val Glu Leu Asn Glu           
65                  70                  75                  80            

tat cat cga gta caa tta gta agt atg gga aag aaa att aga aga gaa        288
Tyr His Arg Val Gln Leu Val Ser Met Gly Lys Lys Ile Arg Arg Glu           
                85                  90                  95                

gat aaa aat cga atc cta tta caa acc ctt tcc tgc gaa aat aaa gaa        336
Asp Lys Asn Arg Ile Leu Leu Gln Thr Leu Ser Cys Glu Asn Lys Glu           
            100                 105                 110                   

tgt acg tta gaa gga ttt ttt gat act tac act cgt ttt ccc gaa gtt        384
Cys Thr Leu Glu Gly Phe Phe Asp Thr Tyr Thr Arg Phe Pro Glu Val           
        115                 120                 125                       

gat cct gcg ttt cgt aaa gat aaa acg ttt aag agc aga ttt caa ata        432
Asp Pro Ala Phe Arg Lys Asp Lys Thr Phe Lys Ser Arg Phe Gln Ile           
    130                 135                 140                           

aca gat tta ggt caa tat aaa gtg cca cag gaa tac agt atg cct aat        480
Thr Asp Leu Gly Gln Tyr Lys Val Pro Gln Glu Tyr Ser Met Pro Asn           
145                 150                 155                 160           

ctc cgc tct ctt cct agt ttt tcc gaa aaa cca att tcc att gga gaa        528
Leu Arg Ser Leu Pro Ser Phe Ser Glu Lys Pro Ile Ser Ile Gly Glu           
                165                 170                 175               

gaa tgg aca caa ccc gct acg gaa agt ttt caa ttt cca gga gga agg        576
Glu Trp Thr Gln Pro Ala Thr Glu Ser Phe Gln Phe Pro Gly Gly Arg           
            180                 185                 190                   

gtt atg atc acg gtt ttt gcg aaa tat aag tat cac ggt gta gac gaa        624
Val Met Ile Thr Val Phe Ala Lys Tyr Lys Tyr His Gly Val Asp Glu           
        195                 200                 205                       

tgg gaa tat caa aag ttg tcc ggt aaa gga gat cgt atc gaa tac aat        672
Trp Glu Tyr Gln Lys Leu Ser Gly Lys Gly Asp Arg Ile Glu Tyr Asn           
    210                 215                 220                           

tat aat tta tat tat gat tct caa atg aac aga acc ggg gtt cca ttt        720
Tyr Asn Leu Tyr Tyr Asp Ser Gln Met Asn Arg Thr Gly Val Pro Phe           
225                 230                 235                 240           

aag atc tac gga ttt gcg cga gga atg gta ttt ttt gat cgc gaa ctt        768
Lys Ile Tyr Gly Phe Ala Arg Gly Met Val Phe Phe Asp Arg Glu Leu           
                245                 250                 255               

gga att cca caa tat aaa agg gtt cag ttg tcg tac act ttt gtc tat        816
Gly Ile Pro Gln Tyr Lys Arg Val Gln Leu Ser Tyr Thr Phe Val Tyr           
            260                 265                 270                   

gaa aat gga atg gcg caa gag atg tcg ttc gac att cac gga gta tat        864
Glu Asn Gly Met Ala Gln Glu Met Ser Phe Asp Ile His Gly Val Tyr           
        275                 280                 285                       

aat aaa aac gta aaa ctt acg gat caa gac aag gac aag ttt gcg gaa        912
Asn Lys Asn Val Lys Leu Thr Asp Gln Asp Lys Asp Lys Phe Ala Glu           
    290                 295                 300                           

gaa atc cgt aaa att tta gga gga gaa ctt cca act gga att gaa cca        960
Glu Ile Arg Lys Ile Leu Gly Gly Glu Leu Pro Thr Gly Ile Glu Pro           
305                 310                 315                 320           

gat tcc gat tca aaa aag aat tta aaa aaa ccg aaa aag gaa acc att       1008
Asp Ser Asp Ser Lys Lys Asn Leu Lys Lys Pro Lys Lys Glu Thr Ile           
                325                 330                 335               

tca tgg ccg gaa gaa gag gat aat caa gcc gca cca gaa agt tcg ccg       1056
Ser Trp Pro Glu Glu Glu Asp Asn Gln Ala Ala Pro Glu Ser Ser Pro           
            340                 345                 350                   

gta gaa att aga aga aca gaa gaa gga atc gct att tct tta aat tca       1104
Val Glu Ile Arg Arg Thr Glu Glu Gly Ile Ala Ile Ser Leu Asn Ser           
        355                 360                 365                       

gtg ttg ttt gat cac aac agc tca gaa ctt aaa caa gaa gca aaa tta       1152
Val Leu Phe Asp His Asn Ser Ser Glu Leu Lys Gln Glu Ala Lys Leu           
    370                 375                 380                           

gaa tta aaa aga atc gca tcc gta ttg aaa aaa tat gca gat aga gaa       1200
Glu Leu Lys Arg Ile Ala Ser Val Leu Lys Lys Tyr Ala Asp Arg Glu           
385                 390                 395                 400           

atc aga att agc ggg cat act gac aat tca ggc ggg gaa gaa tat aat       1248
Ile Arg Ile Ser Gly His Thr Asp Asn Ser Gly Gly Glu Glu Tyr Asn           
                405                 410                 415               

cga aaa ctt tcc aga gaa aga gca ctt tcc gtt ttg aag gaa ctc aga       1296
Arg Lys Leu Ser Arg Glu Arg Ala Leu Ser Val Leu Lys Glu Leu Arg           
            420                 425                 430                   

gat gaa caa ggt ttg gaa gaa aaa aga atg tct tac gaa gga tat ggg       1344
Asp Glu Gln Gly Leu Glu Glu Lys Arg Met Ser Tyr Glu Gly Tyr Gly           
        435                 440                 445                       

aaa tca aaa ccg att gca gat aac tct acg att caa ggt agg caa aaa       1392
Lys Ser Lys Pro Ile Ala Asp Asn Ser Thr Ile Gln Gly Arg Gln Lys           
    450                 455                 460                           

aat cgt agg gta gat att act att gta atg gaa taa                       1428
Asn Arg Arg Val Asp Ile Thr Ile Val Met Glu                               
465                 470                 475                               


<210>  57
<211>  475
<212>  PRT
<213>  Leptospira interrogans serovar Pomona

<400>  57

Met Glu Ser Phe Leu His Phe Pro Tyr Val Leu Lys Glu Ser Tyr Glu 
1               5                   10                  15      


Thr Lys Thr Met Gly Lys Phe Ser Asn Gln Pro Ser Lys Ser Lys Ile 
            20                  25                  30          


Ile Asn Arg Arg Leu Arg Arg Ile Val Ser Tyr Val Phe Ile Ile Ser 
        35                  40                  45              


Thr Leu Ile Gly Phe Thr Ser Thr Phe Pro Glu Glu Ser Asp Lys Val 
    50                  55                  60                  


Leu Phe Arg Trp Lys Leu Lys Pro Gly Glu Asn Val Glu Leu Asn Glu 
65                  70                  75                  80  


Tyr His Arg Val Gln Leu Val Ser Met Gly Lys Lys Ile Arg Arg Glu 
                85                  90                  95      


Asp Lys Asn Arg Ile Leu Leu Gln Thr Leu Ser Cys Glu Asn Lys Glu 
            100                 105                 110         


Cys Thr Leu Glu Gly Phe Phe Asp Thr Tyr Thr Arg Phe Pro Glu Val 
        115                 120                 125             


Asp Pro Ala Phe Arg Lys Asp Lys Thr Phe Lys Ser Arg Phe Gln Ile 
    130                 135                 140                 


Thr Asp Leu Gly Gln Tyr Lys Val Pro Gln Glu Tyr Ser Met Pro Asn 
145                 150                 155                 160 


Leu Arg Ser Leu Pro Ser Phe Ser Glu Lys Pro Ile Ser Ile Gly Glu 
                165                 170                 175     


Glu Trp Thr Gln Pro Ala Thr Glu Ser Phe Gln Phe Pro Gly Gly Arg 
            180                 185                 190         


Val Met Ile Thr Val Phe Ala Lys Tyr Lys Tyr His Gly Val Asp Glu 
        195                 200                 205             


Trp Glu Tyr Gln Lys Leu Ser Gly Lys Gly Asp Arg Ile Glu Tyr Asn 
    210                 215                 220                 


Tyr Asn Leu Tyr Tyr Asp Ser Gln Met Asn Arg Thr Gly Val Pro Phe 
225                 230                 235                 240 


Lys Ile Tyr Gly Phe Ala Arg Gly Met Val Phe Phe Asp Arg Glu Leu 
                245                 250                 255     


Gly Ile Pro Gln Tyr Lys Arg Val Gln Leu Ser Tyr Thr Phe Val Tyr 
            260                 265                 270         


Glu Asn Gly Met Ala Gln Glu Met Ser Phe Asp Ile His Gly Val Tyr 
        275                 280                 285             


Asn Lys Asn Val Lys Leu Thr Asp Gln Asp Lys Asp Lys Phe Ala Glu 
    290                 295                 300                 


Glu Ile Arg Lys Ile Leu Gly Gly Glu Leu Pro Thr Gly Ile Glu Pro 
305                 310                 315                 320 


Asp Ser Asp Ser Lys Lys Asn Leu Lys Lys Pro Lys Lys Glu Thr Ile 
                325                 330                 335     


Ser Trp Pro Glu Glu Glu Asp Asn Gln Ala Ala Pro Glu Ser Ser Pro 
            340                 345                 350         


Val Glu Ile Arg Arg Thr Glu Glu Gly Ile Ala Ile Ser Leu Asn Ser 
        355                 360                 365             


Val Leu Phe Asp His Asn Ser Ser Glu Leu Lys Gln Glu Ala Lys Leu 
    370                 375                 380                 


Glu Leu Lys Arg Ile Ala Ser Val Leu Lys Lys Tyr Ala Asp Arg Glu 
385                 390                 395                 400 


Ile Arg Ile Ser Gly His Thr Asp Asn Ser Gly Gly Glu Glu Tyr Asn 
                405                 410                 415     


Arg Lys Leu Ser Arg Glu Arg Ala Leu Ser Val Leu Lys Glu Leu Arg 
            420                 425                 430         


Asp Glu Gln Gly Leu Glu Glu Lys Arg Met Ser Tyr Glu Gly Tyr Gly 
        435                 440                 445             


Lys Ser Lys Pro Ile Ala Asp Asn Ser Thr Ile Gln Gly Arg Gln Lys 
    450                 455                 460                 


Asn Arg Arg Val Asp Ile Thr Ile Val Met Glu 
465                 470                 475 


<210>  58
<211>  1683
<212>  DNA
<213>  Leptospira interrogans serovar Pomona


<220>
<221>  CDS
<222>  (1)..(1683)

<400>  58
atg aaa caa ttt tta ttt tta ctg tgt gta ttt cta ctc ttt caa aat         48
Met Lys Gln Phe Leu Phe Leu Leu Cys Val Phe Leu Leu Phe Gln Asn           
1               5                   10                  15                

tgt tct gtc aag ccc acg gaa aat ccg tgc gat acg agt act tct ctt         96
Cys Ser Val Lys Pro Thr Glu Asn Pro Cys Asp Thr Ser Thr Ser Leu           
            20                  25                  30                    

ttt tat aaa tct ttg ttc tta aat ttt att tta act tcc ggc aaa acg        144
Phe Tyr Lys Ser Leu Phe Leu Asn Phe Ile Leu Thr Ser Gly Lys Thr           
        35                  40                  45                        

agt att tgc ggt atg cac acg tcg gtt cag ttg cct ccc cct acg att        192
Ser Ile Cys Gly Met His Thr Ser Val Gln Leu Pro Pro Pro Thr Ile           
    50                  55                  60                            

ctc aac ata aaa tca aaa agt act ttg aat aca gga ttt tta att ggt        240
Leu Asn Ile Lys Ser Lys Ser Thr Leu Asn Thr Gly Phe Leu Ile Gly           
65                  70                  75                  80            

gaa atg gat gag tct gct tcc gga gtt caa att tct tta gat tcg ggt        288
Glu Met Asp Glu Ser Ala Ser Gly Val Gln Ile Ser Leu Asp Ser Gly           
                85                  90                  95                

cca ttt atg gac gct caa act tct ggc aat cag tgg aaa ttt caa ctt        336
Pro Phe Met Asp Ala Gln Thr Ser Gly Asn Gln Trp Lys Phe Gln Leu           
            100                 105                 110                   

cct gcc gca ggt gtt tct act aca att cct tca agt gga att tgg aga        384
Pro Ala Ala Gly Val Ser Thr Thr Ile Pro Ser Ser Gly Ile Trp Arg           
        115                 120                 125                       

gac tgg agt tta cat aca att tcg gtt cga tct act tct aag gaa tca        432
Asp Trp Ser Leu His Thr Ile Ser Val Arg Ser Thr Ser Lys Glu Ser           
    130                 135                 140                           

aat tct att ccg att aca atc act gtt caa aaa ggt tca aac aag gat        480
Asn Ser Ile Pro Ile Thr Ile Thr Val Gln Lys Gly Ser Asn Lys Asp           
145                 150                 155                 160           

att aac ggc gac ggt tat cca gat gca ttg att ggt tct caa gct gca        528
Ile Asn Gly Asp Gly Tyr Pro Asp Ala Leu Ile Gly Ser Gln Ala Ala           
                165                 170                 175               

aat cga gtt agg gct tat ctt tct ctt ggg aaa gca aag ggt tta gat        576
Asn Arg Val Arg Ala Tyr Leu Ser Leu Gly Lys Ala Lys Gly Leu Asp           
            180                 185                 190                   

ttg gtt ccg gtc act tta cta aat ggg gca ggt gga ttt ggt tat tcc        624
Leu Val Pro Val Thr Leu Leu Asn Gly Ala Gly Gly Phe Gly Tyr Ser           
        195                 200                 205                       

gtc aag tta ggc gac atc gat gga gat gga tac gcc gat gca gtt gta        672
Val Lys Leu Gly Asp Ile Asp Gly Asp Gly Tyr Ala Asp Ala Val Val           
    210                 215                 220                           

gga agt gca aca aat aca ttc gct att tat tta gga tca atc ggt ggg        720
Gly Ser Ala Thr Asn Thr Phe Ala Ile Tyr Leu Gly Ser Ile Gly Gly           
225                 230                 235                 240           

ctt tcg aca acg gcg att aat tat atc cct att ggt gtt ggt ggt tta        768
Leu Ser Thr Thr Ala Ile Asn Tyr Ile Pro Ile Gly Val Gly Gly Leu           
                245                 250                 255               

ttg aat gtg gat gta gga gat ata aac gga gac gga ttt tca gac gtt        816
Leu Asn Val Asp Val Gly Asp Ile Asn Gly Asp Gly Phe Ser Asp Val           
            260                 265                 270                   

ttg att ggt gta cct tat gac gta gga aat att ggg cgt gtt tat tct        864
Leu Ile Gly Val Pro Tyr Asp Val Gly Asn Ile Gly Arg Val Tyr Ser           
        275                 280                 285                       

tat ttt tca aat gga gtt atg ggg caa ggt gtt acg ttt ggt caa caa        912
Tyr Phe Ser Asn Gly Val Met Gly Gln Gly Val Thr Phe Gly Gln Gln           
    290                 295                 300                           

ttg aac aat cct gga aat gca ggt agt gct gca ttt tac gga tat gcc        960
Leu Asn Asn Pro Gly Asn Ala Gly Ser Ala Ala Phe Tyr Gly Tyr Ala           
305                 310                 315                 320           

att acg tta ggt gat att aat gga gat ggt aaa tcg gat gcg att ata       1008
Ile Thr Leu Gly Asp Ile Asn Gly Asp Gly Lys Ser Asp Ala Ile Ile           
                325                 330                 335               

gga gcg gtc ggt tct gga cag gtc ggc gct tct ttt att tat ctt gcg       1056
Gly Ala Val Gly Ser Gly Gln Val Gly Ala Ser Phe Ile Tyr Leu Ala           
            340                 345                 350                   

caa gca gca ggg gct ttt gct gct tat tct caa aca att acg gga tcg       1104
Gln Ala Ala Gly Ala Phe Ala Ala Tyr Ser Gln Thr Ile Thr Gly Ser           
        355                 360                 365                       

gct gca aat gaa tgg tat gca aat tca gca att gct acc gat ata aac       1152
Ala Ala Asn Glu Trp Tyr Ala Asn Ser Ala Ile Ala Thr Asp Ile Asn           
    370                 375                 380                           

cgg gat gga ttt gcg gat tta ttt gtg ggg gct tat caa gaa tcg ggc       1200
Arg Asp Gly Phe Ala Asp Leu Phe Val Gly Ala Tyr Gln Glu Ser Gly           
385                 390                 395                 400           

ggc gtt gga aga gta cat tta tat tta tct aat tta gga att ctt gtg       1248
Gly Val Gly Arg Val His Leu Tyr Leu Ser Asn Leu Gly Ile Leu Val           
                405                 410                 415               

aat acc gcc aac ggt cca att tca gga ttg gtt ggg tca caa act gga       1296
Asn Thr Ala Asn Gly Pro Ile Ser Gly Leu Val Gly Ser Gln Thr Gly           
            420                 425                 430                   

act tct gtg gca act gga gat gta aac ggt gat gga ttt tta gat ctt       1344
Thr Ser Val Ala Thr Gly Asp Val Asn Gly Asp Gly Phe Leu Asp Leu           
        435                 440                 445                       

ctt acc gga ggt tat tct tac act tct acg ttt cca aat caa ggt tat       1392
Leu Thr Gly Gly Tyr Ser Tyr Thr Ser Thr Phe Pro Asn Gln Gly Tyr           
    450                 455                 460                           

gcg att act cat tta act acg ggt gat aca atg ggt tta act gtg aac       1440
Ala Ile Thr His Leu Thr Thr Gly Asp Thr Met Gly Leu Thr Val Asn           
465                 470                 475                 480           

cct tta aat ctt cta acg gtt cca gtg aat tta gga gat atg gga aat       1488
Pro Leu Asn Leu Leu Thr Val Pro Val Asn Leu Gly Asp Met Gly Asn           
                485                 490                 495               

tca att gct tcg gta gat att aac ggt gac ggt tta agt gac gtt ctt       1536
Ser Ile Ala Ser Val Asp Ile Asn Gly Asp Gly Leu Ser Asp Val Leu           
            500                 505                 510                   

gtg gga gct cct agt tcc gta ggt gga aca aat gtt gga aac gtt tac       1584
Val Gly Ala Pro Ser Ser Val Gly Gly Thr Asn Val Gly Asn Val Tyr           
        515                 520                 525                       

ctt tat ata tca aac gga ttg gac gga tat act tcg gcc cca caa att       1632
Leu Tyr Ile Ser Asn Gly Leu Asp Gly Tyr Thr Ser Ala Pro Gln Ile           
    530                 535                 540                           

ttc gtc gaa cca gat gta aac gga acg ttt ggg act tcc gtg gat tta       1680
Phe Val Glu Pro Asp Val Asn Gly Thr Phe Gly Thr Ser Val Asp Leu           
545                 550                 555                 560           

tga                                                                   1683


<210>  59
<211>  560
<212>  PRT
<213>  Leptospira interrogans serovar Pomona

<400>  59

Met Lys Gln Phe Leu Phe Leu Leu Cys Val Phe Leu Leu Phe Gln Asn 
1               5                   10                  15      


Cys Ser Val Lys Pro Thr Glu Asn Pro Cys Asp Thr Ser Thr Ser Leu 
            20                  25                  30          


Phe Tyr Lys Ser Leu Phe Leu Asn Phe Ile Leu Thr Ser Gly Lys Thr 
        35                  40                  45              


Ser Ile Cys Gly Met His Thr Ser Val Gln Leu Pro Pro Pro Thr Ile 
    50                  55                  60                  


Leu Asn Ile Lys Ser Lys Ser Thr Leu Asn Thr Gly Phe Leu Ile Gly 
65                  70                  75                  80  


Glu Met Asp Glu Ser Ala Ser Gly Val Gln Ile Ser Leu Asp Ser Gly 
                85                  90                  95      


Pro Phe Met Asp Ala Gln Thr Ser Gly Asn Gln Trp Lys Phe Gln Leu 
            100                 105                 110         


Pro Ala Ala Gly Val Ser Thr Thr Ile Pro Ser Ser Gly Ile Trp Arg 
        115                 120                 125             


Asp Trp Ser Leu His Thr Ile Ser Val Arg Ser Thr Ser Lys Glu Ser 
    130                 135                 140                 


Asn Ser Ile Pro Ile Thr Ile Thr Val Gln Lys Gly Ser Asn Lys Asp 
145                 150                 155                 160 


Ile Asn Gly Asp Gly Tyr Pro Asp Ala Leu Ile Gly Ser Gln Ala Ala 
                165                 170                 175     


Asn Arg Val Arg Ala Tyr Leu Ser Leu Gly Lys Ala Lys Gly Leu Asp 
            180                 185                 190         


Leu Val Pro Val Thr Leu Leu Asn Gly Ala Gly Gly Phe Gly Tyr Ser 
        195                 200                 205             


Val Lys Leu Gly Asp Ile Asp Gly Asp Gly Tyr Ala Asp Ala Val Val 
    210                 215                 220                 


Gly Ser Ala Thr Asn Thr Phe Ala Ile Tyr Leu Gly Ser Ile Gly Gly 
225                 230                 235                 240 


Leu Ser Thr Thr Ala Ile Asn Tyr Ile Pro Ile Gly Val Gly Gly Leu 
                245                 250                 255     


Leu Asn Val Asp Val Gly Asp Ile Asn Gly Asp Gly Phe Ser Asp Val 
            260                 265                 270         


Leu Ile Gly Val Pro Tyr Asp Val Gly Asn Ile Gly Arg Val Tyr Ser 
        275                 280                 285             


Tyr Phe Ser Asn Gly Val Met Gly Gln Gly Val Thr Phe Gly Gln Gln 
    290                 295                 300                 


Leu Asn Asn Pro Gly Asn Ala Gly Ser Ala Ala Phe Tyr Gly Tyr Ala 
305                 310                 315                 320 


Ile Thr Leu Gly Asp Ile Asn Gly Asp Gly Lys Ser Asp Ala Ile Ile 
                325                 330                 335     


Gly Ala Val Gly Ser Gly Gln Val Gly Ala Ser Phe Ile Tyr Leu Ala 
            340                 345                 350         


Gln Ala Ala Gly Ala Phe Ala Ala Tyr Ser Gln Thr Ile Thr Gly Ser 
        355                 360                 365             


Ala Ala Asn Glu Trp Tyr Ala Asn Ser Ala Ile Ala Thr Asp Ile Asn 
    370                 375                 380                 


Arg Asp Gly Phe Ala Asp Leu Phe Val Gly Ala Tyr Gln Glu Ser Gly 
385                 390                 395                 400 


Gly Val Gly Arg Val His Leu Tyr Leu Ser Asn Leu Gly Ile Leu Val 
                405                 410                 415     


Asn Thr Ala Asn Gly Pro Ile Ser Gly Leu Val Gly Ser Gln Thr Gly 
            420                 425                 430         


Thr Ser Val Ala Thr Gly Asp Val Asn Gly Asp Gly Phe Leu Asp Leu 
        435                 440                 445             


Leu Thr Gly Gly Tyr Ser Tyr Thr Ser Thr Phe Pro Asn Gln Gly Tyr 
    450                 455                 460                 


Ala Ile Thr His Leu Thr Thr Gly Asp Thr Met Gly Leu Thr Val Asn 
465                 470                 475                 480 


Pro Leu Asn Leu Leu Thr Val Pro Val Asn Leu Gly Asp Met Gly Asn 
                485                 490                 495     


Ser Ile Ala Ser Val Asp Ile Asn Gly Asp Gly Leu Ser Asp Val Leu 
            500                 505                 510         


Val Gly Ala Pro Ser Ser Val Gly Gly Thr Asn Val Gly Asn Val Tyr 
        515                 520                 525             


Leu Tyr Ile Ser Asn Gly Leu Asp Gly Tyr Thr Ser Ala Pro Gln Ile 
    530                 535                 540                 


Phe Val Glu Pro Asp Val Asn Gly Thr Phe Gly Thr Ser Val Asp Leu 
545                 550                 555                 560 


<210>  60
<211>  3492
<212>  DNA
<213>  Leptospira interrogans serovar Pomona


<220>
<221>  CDS
<222>  (1)..(3492)

<400>  60
ttg aac aca tcc atc caa gtt ggt ttt agt caa aaa ttg gat tct tct         48
Met Asn Thr Ser Ile Gln Val Gly Phe Ser Gln Lys Leu Asp Ser Ser           
1               5                   10                  15                

agt atc caa tct caa tcg atc caa cta aca caa gga aat acg atc att         96
Ser Ile Gln Ser Gln Ser Ile Gln Leu Thr Gln Gly Asn Thr Ile Ile           
            20                  25                  30                    

ccg gga aat ttc act tct aca gaa aaa act ctt tta ttc aat cca acg        144
Pro Gly Asn Phe Thr Ser Thr Glu Lys Thr Leu Leu Phe Asn Pro Thr           
        35                  40                  45                        

tct tcc ttg gct gca tca act gta tat tcc gtt agc att tcc aaa gac        192
Ser Ser Leu Ala Ala Ser Thr Val Tyr Ser Val Ser Ile Ser Lys Asp           
    50                  55                  60                            

ata aaa tca atg gac ggc tcc tct ctt tca gaa gac tat act tgg agc        240
Ile Lys Ser Met Asp Gly Ser Ser Leu Ser Glu Asp Tyr Thr Trp Ser           
65                  70                  75                  80            

ttt acc acc aac acg att gtt gat tta gtc gcg cca gac gta tct tta        288
Phe Thr Thr Asn Thr Ile Val Asp Leu Val Ala Pro Asp Val Ser Leu           
                85                  90                  95                

aga acc cct acc ata ggt gcc aat tta gtt cct aat aat act tcc gtt        336
Arg Thr Pro Thr Ile Gly Ala Asn Leu Val Pro Asn Asn Thr Ser Val           
            100                 105                 110                   

caa att gcg ttt act gaa aca atg aat tgc act tcc atc aac att gta        384
Gln Ile Ala Phe Thr Glu Thr Met Asn Cys Thr Ser Ile Asn Ile Val           
        115                 120                 125                       

aat ttt aca tta aaa aat aat gtt acc aat gta tta gaa cct agt aat        432
Asn Phe Thr Leu Lys Asn Asn Val Thr Asn Val Leu Glu Pro Ser Asn           
    130                 135                 140                           

gta gtt tgt tta gga tcc gtt gcc acc ctt acc cct aat aat cct ctt        480
Val Val Cys Leu Gly Ser Val Ala Thr Leu Thr Pro Asn Asn Pro Leu           
145                 150                 155                 160           

gct ttt aat act gtt tat cgt gtg gat att ctt tct aca gca aaa gat        528
Ala Phe Asn Thr Val Tyr Arg Val Asp Ile Leu Ser Thr Ala Lys Asp           
                165                 170                 175               

ctt gct aat aat cct ctt gta aac gca tat aac tgg act ttt aca acc        576
Leu Ala Asn Asn Pro Leu Val Asn Ala Tyr Asn Trp Thr Phe Thr Thr           
            180                 185                 190                   

gga gtt gcc ccc gat tta acg gtt cca acc gtc tcc ttt gta aat ccc        624
Gly Val Ala Pro Asp Leu Thr Val Pro Thr Val Ser Phe Val Asn Pro           
        195                 200                 205                       

act ccc aat gca caa aac gtt cct atc aac gaa aca atc agt att gcc        672
Thr Pro Asn Ala Gln Asn Val Pro Ile Asn Glu Thr Ile Ser Ile Ala           
    210                 215                 220                           

ttt agt gaa cct atc aat tgt gct acg atc atc gga agt att gtc tta        720
Phe Ser Glu Pro Ile Asn Cys Ala Thr Ile Ile Gly Ser Ile Val Leu           
225                 230                 235                 240           

gat gat aat ata ctt att cct gga agc gta aac ggg aat ccg ggt tgt        768
Asp Asp Asn Ile Leu Ile Pro Gly Ser Val Asn Gly Asn Pro Gly Cys           
                245                 250                 255               

aca ggc aca acc gca tcc ttt act cct tta ggc aat ttg aca cca aat        816
Thr Gly Thr Thr Ala Ser Phe Thr Pro Leu Gly Asn Leu Thr Pro Asn           
            260                 265                 270                   

acg aat tat acg gtt acc gtc tca aat gcg att acg gat ttg caa aac        864
Thr Asn Tyr Thr Val Thr Val Ser Asn Ala Ile Thr Asp Leu Gln Asn           
        275                 280                 285                       

aat cca ctt aca cct tct acc tgg agt ttt acg acg gct gct gca gtc        912
Asn Pro Leu Thr Pro Ser Thr Trp Ser Phe Thr Thr Ala Ala Ala Val           
    290                 295                 300                           

gat cag act caa ccc acg gtt aca ttt act gta ccc tcc gcc aac gca        960
Asp Gln Thr Gln Pro Thr Val Thr Phe Thr Val Pro Ser Ala Asn Ala           
305                 310                 315                 320           

aac ggc gta ggg acc aat gtc aac cct atg gta gtt ttt agc gaa cct       1008
Asn Gly Val Gly Thr Asn Val Asn Pro Met Val Val Phe Ser Glu Pro           
                325                 330                 335               

atg tct tgc gct tcc gtg acc tcc gca tcc ttt cga tta aag agg cag       1056
Met Ser Cys Ala Ser Val Thr Ser Ala Ser Phe Arg Leu Lys Arg Gln           
            340                 345                 350                   

gca acc ggg gtt tat ctt ata gga agt gta aat tgt ttt gga act tcc       1104
Ala Thr Gly Val Tyr Leu Ile Gly Ser Val Asn Cys Phe Gly Thr Ser           
        355                 360                 365                       

gct acc tgg acc cca gat cct gta aat ccg ctt gcc ttt aat act act       1152
Ala Thr Trp Thr Pro Asp Pro Val Asn Pro Leu Ala Phe Asn Thr Thr           
    370                 375                 380                           

tac acc gta gaa atc gat cag ggt gca tta gat act ttt aat aat cct       1200
Tyr Thr Val Glu Ile Asp Gln Gly Ala Leu Asp Thr Phe Asn Asn Pro           
385                 390                 395                 400           

ctc att cca ata aat tgg aac ttt act aca ggc cca gga ccc gat cta       1248
Leu Ile Pro Ile Asn Trp Asn Phe Thr Thr Gly Pro Gly Pro Asp Leu           
                405                 410                 415               

act cct ccc agt gtt gcc gtc gtt act ccc gca aac gct gcg ata ggc       1296
Thr Pro Pro Ser Val Ala Val Val Thr Pro Ala Asn Ala Ala Ile Gly           
            420                 425                 430                   

gtt ccg acc aac gga ggt gta agt atc gct ttt agt gaa gcc atg aat       1344
Val Pro Thr Asn Gly Gly Val Ser Ile Ala Phe Ser Glu Ala Met Asn           
        435                 440                 445                       

tgt gga agt att tta gga gga atc acc ctg gac gat gat cct aca act       1392
Cys Gly Ser Ile Leu Gly Gly Ile Thr Leu Asp Asp Asp Pro Thr Thr           
    450                 455                 460                           

ccg ggt act gtg att cca atc aat atc aat tgt aac gga aat act gtc       1440
Pro Gly Thr Val Ile Pro Ile Asn Ile Asn Cys Asn Gly Asn Thr Val           
465                 470                 475                 480           

tct ttt gcc ccg aca atc cct cca ctt gcc ttt aat aca acc tac aca       1488
Ser Phe Ala Pro Thr Ile Pro Pro Leu Ala Phe Asn Thr Thr Tyr Thr           
                485                 490                 495               

gta acg att tta aat acg gtt acg gac agt aat aat aat gca cta aac       1536
Val Thr Ile Leu Asn Thr Val Thr Asp Ser Asn Asn Asn Ala Leu Asn           
            500                 505                 510                   

gga gga aat tac gct tgg tct ttt aca aca gga gtg gca cca gac cta       1584
Gly Gly Asn Tyr Ala Trp Ser Phe Thr Thr Gly Val Ala Pro Asp Leu           
        515                 520                 525                       

gtt cct cct caa gtt tct ctt gta agc cct ctc tcg gga gca gta ggt       1632
Val Pro Pro Gln Val Ser Leu Val Ser Pro Leu Ser Gly Ala Val Gly           
    530                 535                 540                           

gtc gca aca aat gca aac att aca gtt gca ttt aat gaa acc atc aat       1680
Val Ala Thr Asn Ala Asn Ile Thr Val Ala Phe Asn Glu Thr Ile Asn           
545                 550                 555                 560           

tgt tcc acc ttg aat ttt acg gtt aat aac gga atc aat ggt act gtg       1728
Cys Ser Thr Leu Asn Phe Thr Val Asn Asn Gly Ile Asn Gly Thr Val           
                565                 570                 575               

aac tgt tca gga tcc tct gct act ttt att cct agc gct tta acc cct       1776
Asn Cys Ser Gly Ser Ser Ala Thr Phe Ile Pro Ser Ala Leu Thr Pro           
            580                 585                 590                   

cta aat gcc ggt aca aat tat aca gca aca atc cta aca gta aat gat       1824
Leu Asn Ala Gly Thr Asn Tyr Thr Ala Thr Ile Leu Thr Val Asn Asp           
        595                 600                 605                       

att gta gga aat cca atc ggt gct gcg ttt ggt tgg agt ttt aca acc       1872
Ile Val Gly Asn Pro Ile Gly Ala Ala Phe Gly Trp Ser Phe Thr Thr           
    610                 615                 620                           

gga gcc gct cca gat gtg act cct cct gtc gtt acg atc caa aat ctt       1920
Gly Ala Ala Pro Asp Val Thr Pro Pro Val Val Thr Ile Gln Asn Leu           
625                 630                 635                 640           

aga aat aat tct atc gta gaa act ggt ttc gta att gga acg gca aca       1968
Arg Asn Asn Ser Ile Val Glu Thr Gly Phe Val Ile Gly Thr Ala Thr           
                645                 650                 655               

gat gca ggc aca att act tct gta gaa gtt tct ttg gac aat ggc gct       2016
Asp Ala Gly Thr Ile Thr Ser Val Glu Val Ser Leu Asp Asn Gly Ala           
            660                 665                 670                   

ttt gtg ccc gca acc gga acc aat cct tgg aaa ttt aaa ctt cct tcg       2064
Phe Val Pro Ala Thr Gly Thr Asn Pro Trp Lys Phe Lys Leu Pro Ser           
        675                 680                 685                       

gat ata aat act tgg aag caa aac tct caa cat acg atc att gca aga       2112
Asp Ile Asn Thr Trp Lys Gln Asn Ser Gln His Thr Ile Ile Ala Arg           
    690                 695                 700                           

gct aag gac tta gcc aat aac ctt aca act aca gca gcc att tcg gtt       2160
Ala Lys Asp Leu Ala Asn Asn Leu Thr Thr Thr Ala Ala Ile Ser Val           
705                 710                 715                 720           

cga aaa gga aac aat aaa gat ata aac gga gac gga tac gtt gat ctt       2208
Arg Lys Gly Asn Asn Lys Asp Ile Asn Gly Asp Gly Tyr Val Asp Leu           
                725                 730                 735               

gta tct gca gaa tac gga cag ggt tta ctt tat att ttt cat tct tcc       2256
Val Ser Ala Glu Tyr Gly Gln Gly Leu Leu Tyr Ile Phe His Ser Ser           
            740                 745                 750                   

ggg aac gct gga atg aca att aca aac gca caa tcc gca agt aag atc       2304
Gly Asn Ala Gly Met Thr Ile Thr Asn Ala Gln Ser Ala Ser Lys Ile           
        755                 760                 765                       

att gta gga gtc gcg gcg gaa gaa ttt gga aga act gtt tct atg gga       2352
Ile Val Gly Val Ala Ala Glu Glu Phe Gly Arg Thr Val Ser Met Gly           
    770                 775                 780                           

gat tta aac gga gat gga ttt gca gac gta att tct ggt gct cct ggt       2400
Asp Leu Asn Gly Asp Gly Phe Ala Asp Val Ile Ser Gly Ala Pro Gly           
785                 790                 795                 800           

tgg aac ggt gcc caa ggt agg gtt tat ata ttt cat tct tcc gga aac       2448
Trp Asn Gly Ala Gln Gly Arg Val Tyr Ile Phe His Ser Ser Gly Asn           
                805                 810                 815               

gct gga gtc aat att tcc ttt tcc ggt ttt gcc act aaa acg atc agt       2496
Ala Gly Val Asn Ile Ser Phe Ser Gly Phe Ala Thr Lys Thr Ile Ser           
            820                 825                 830                   

gga gcc aat gcg gga gct aga ttt gga gat agt att gtt aca ggt gat       2544
Gly Ala Asn Ala Gly Ala Arg Phe Gly Asp Ser Ile Val Thr Gly Asp           
        835                 840                 845                       

tta aac gga gac ggc tac gca gac cta gca tca gga gaa ccc gtt ttt       2592
Leu Asn Gly Asp Gly Tyr Ala Asp Leu Ala Ser Gly Glu Pro Val Phe           
    850                 855                 860                           

aat ggt tct cag ggt aga gtc tat gta ttt cat tcc gct gga gcc gct       2640
Asn Gly Ser Gln Gly Arg Val Tyr Val Phe His Ser Ala Gly Ala Ala           
865                 870                 875                 880           

gga gtt aca caa ata aat tcg gct gct gca aat tct aca ctc aca ggt       2688
Gly Val Thr Gln Ile Asn Ser Ala Ala Ala Asn Ser Thr Leu Thr Gly           
                885                 890                 895               

gaa aac gca act gat cgt ttc gga tat tcg ttg agc act gga aat atg       2736
Glu Asn Ala Thr Asp Arg Phe Gly Tyr Ser Leu Ser Thr Gly Asn Met           
            900                 905                 910                   

aac gga gat aat ttt gca gat ctt gca att gga gca cct ggt tat ggc       2784
Asn Gly Asp Asn Phe Ala Asp Leu Ala Ile Gly Ala Pro Gly Tyr Gly           
        915                 920                 925                       

gct ggc gta ggt gga gga ttt gta gta aac caa ggt aaa gtt tat ata       2832
Ala Gly Val Gly Gly Gly Phe Val Val Asn Gln Gly Lys Val Tyr Ile           
    930                 935                 940                           

cat cac ggg gcg gct ggt gga ttg gga gga gta att aca act ctt acc       2880
His His Gly Ala Ala Gly Gly Leu Gly Gly Val Ile Thr Thr Leu Thr           
945                 950                 955                 960           

aat gat agc gct gga aat gct ggg gaa ttt ggt atc agt tta ttt aca       2928
Asn Asp Ser Ala Gly Asn Ala Gly Glu Phe Gly Ile Ser Leu Phe Thr           
                965                 970                 975               

gcc gat ttt aac gga gac ggt aat tcc gat ctt gca att gga agt cca       2976
Ala Asp Phe Asn Gly Asp Gly Asn Ser Asp Leu Ala Ile Gly Ser Pro           
            980                 985                 990                   

aat tta ggg ggt gga act gga aga  gtt tcc gta ttt acg  tct gca gga     3024
Asn Leu Gly Gly Gly Thr Gly Arg  Val Ser Val Phe Thr  Ser Ala Gly         
        995                 1000                 1005                     

ggt gta  ggt ata aat aca tct  acg att gga aac gct  ccg ctt atg        3069
Gly Val  Gly Ile Asn Thr Ser  Thr Ile Gly Asn Ala  Pro Leu Met            
    1010                 1015                 1020                        

atc aat  gga acg gct gtg ggt  aat gca ttt gga att  tct tta acc        3114
Ile Asn  Gly Thr Ala Val Gly  Asn Ala Phe Gly Ile  Ser Leu Thr            
    1025                 1030                 1035                        

gca cag  gat tta aat tta gat  gga aga ccg gat tta  att tcc gca        3159
Ala Gln  Asp Leu Asn Leu Asp  Gly Arg Pro Asp Leu  Ile Ser Ala            
    1040                 1045                 1050                        

acc gta  att ccc aat agg gta  ttc gtt ttc cac atg  cca ggt gca        3204
Thr Val  Ile Pro Asn Arg Val  Phe Val Phe His Met  Pro Gly Ala            
    1055                 1060                 1065                        

gga gct  atc ggt gga ttt cta  acc act ggt aat gca  act aca caa        3249
Gly Ala  Ile Gly Gly Phe Leu  Thr Thr Gly Asn Ala  Thr Thr Gln            
    1070                 1075                 1080                        

atc acg  agt gca ttt gca gga  atc ggg gtt tcc cca  aat gca cct        3294
Ile Thr  Ser Ala Phe Ala Gly  Ile Gly Val Ser Pro  Asn Ala Pro            
    1085                 1090                 1095                        

aaa act  cct att tcc ggc gga  gac atc aac gga gac  gga ttt cca        3339
Lys Thr  Pro Ile Ser Gly Gly  Asp Ile Asn Gly Asp  Gly Phe Pro            
    1100                 1105                 1110                        

gac tta  ttt gtc ggg gga agt  tct gat aat att ttt  att ttc cat        3384
Asp Leu  Phe Val Gly Gly Ser  Ser Asp Asn Ile Phe  Ile Phe His            
    1115                 1120                 1125                        

tct tca  acg gtt gga act ggt  tta tta aca aat act  act gca acc        3429
Ser Ser  Thr Val Gly Thr Gly  Leu Leu Thr Asn Thr  Thr Ala Thr            
    1130                 1135                 1140                        

gct gca  ggc gca att acc agt  tcc gga ctt gcc aat  ggc ttt ttt        3474
Ala Ala  Gly Ala Ile Thr Ser  Ser Gly Leu Ala Asn  Gly Phe Phe            
    1145                 1150                 1155                        

gga tgt  agc gtt tat tga                                              3492
Gly Cys  Ser Val Tyr                                                      
    1160                                                                  


<210>  61
<211>  1163
<212>  PRT
<213>  Leptospira interrogans serovar Pomona

<400>  61

Met Asn Thr Ser Ile Gln Val Gly Phe Ser Gln Lys Leu Asp Ser Ser 
1               5                   10                  15      


Ser Ile Gln Ser Gln Ser Ile Gln Leu Thr Gln Gly Asn Thr Ile Ile 
            20                  25                  30          


Pro Gly Asn Phe Thr Ser Thr Glu Lys Thr Leu Leu Phe Asn Pro Thr 
        35                  40                  45              


Ser Ser Leu Ala Ala Ser Thr Val Tyr Ser Val Ser Ile Ser Lys Asp 
    50                  55                  60                  


Ile Lys Ser Met Asp Gly Ser Ser Leu Ser Glu Asp Tyr Thr Trp Ser 
65                  70                  75                  80  


Phe Thr Thr Asn Thr Ile Val Asp Leu Val Ala Pro Asp Val Ser Leu 
                85                  90                  95      


Arg Thr Pro Thr Ile Gly Ala Asn Leu Val Pro Asn Asn Thr Ser Val 
            100                 105                 110         


Gln Ile Ala Phe Thr Glu Thr Met Asn Cys Thr Ser Ile Asn Ile Val 
        115                 120                 125             


Asn Phe Thr Leu Lys Asn Asn Val Thr Asn Val Leu Glu Pro Ser Asn 
    130                 135                 140                 


Val Val Cys Leu Gly Ser Val Ala Thr Leu Thr Pro Asn Asn Pro Leu 
145                 150                 155                 160 


Ala Phe Asn Thr Val Tyr Arg Val Asp Ile Leu Ser Thr Ala Lys Asp 
                165                 170                 175     


Leu Ala Asn Asn Pro Leu Val Asn Ala Tyr Asn Trp Thr Phe Thr Thr 
            180                 185                 190         


Gly Val Ala Pro Asp Leu Thr Val Pro Thr Val Ser Phe Val Asn Pro 
        195                 200                 205             


Thr Pro Asn Ala Gln Asn Val Pro Ile Asn Glu Thr Ile Ser Ile Ala 
    210                 215                 220                 


Phe Ser Glu Pro Ile Asn Cys Ala Thr Ile Ile Gly Ser Ile Val Leu 
225                 230                 235                 240 


Asp Asp Asn Ile Leu Ile Pro Gly Ser Val Asn Gly Asn Pro Gly Cys 
                245                 250                 255     


Thr Gly Thr Thr Ala Ser Phe Thr Pro Leu Gly Asn Leu Thr Pro Asn 
            260                 265                 270         


Thr Asn Tyr Thr Val Thr Val Ser Asn Ala Ile Thr Asp Leu Gln Asn 
        275                 280                 285             


Asn Pro Leu Thr Pro Ser Thr Trp Ser Phe Thr Thr Ala Ala Ala Val 
    290                 295                 300                 


Asp Gln Thr Gln Pro Thr Val Thr Phe Thr Val Pro Ser Ala Asn Ala 
305                 310                 315                 320 


Asn Gly Val Gly Thr Asn Val Asn Pro Met Val Val Phe Ser Glu Pro 
                325                 330                 335     


Met Ser Cys Ala Ser Val Thr Ser Ala Ser Phe Arg Leu Lys Arg Gln 
            340                 345                 350         


Ala Thr Gly Val Tyr Leu Ile Gly Ser Val Asn Cys Phe Gly Thr Ser 
        355                 360                 365             


Ala Thr Trp Thr Pro Asp Pro Val Asn Pro Leu Ala Phe Asn Thr Thr 
    370                 375                 380                 


Tyr Thr Val Glu Ile Asp Gln Gly Ala Leu Asp Thr Phe Asn Asn Pro 
385                 390                 395                 400 


Leu Ile Pro Ile Asn Trp Asn Phe Thr Thr Gly Pro Gly Pro Asp Leu 
                405                 410                 415     


Thr Pro Pro Ser Val Ala Val Val Thr Pro Ala Asn Ala Ala Ile Gly 
            420                 425                 430         


Val Pro Thr Asn Gly Gly Val Ser Ile Ala Phe Ser Glu Ala Met Asn 
        435                 440                 445             


Cys Gly Ser Ile Leu Gly Gly Ile Thr Leu Asp Asp Asp Pro Thr Thr 
    450                 455                 460                 


Pro Gly Thr Val Ile Pro Ile Asn Ile Asn Cys Asn Gly Asn Thr Val 
465                 470                 475                 480 


Ser Phe Ala Pro Thr Ile Pro Pro Leu Ala Phe Asn Thr Thr Tyr Thr 
                485                 490                 495     


Val Thr Ile Leu Asn Thr Val Thr Asp Ser Asn Asn Asn Ala Leu Asn 
            500                 505                 510         


Gly Gly Asn Tyr Ala Trp Ser Phe Thr Thr Gly Val Ala Pro Asp Leu 
        515                 520                 525             


Val Pro Pro Gln Val Ser Leu Val Ser Pro Leu Ser Gly Ala Val Gly 
    530                 535                 540                 


Val Ala Thr Asn Ala Asn Ile Thr Val Ala Phe Asn Glu Thr Ile Asn 
545                 550                 555                 560 


Cys Ser Thr Leu Asn Phe Thr Val Asn Asn Gly Ile Asn Gly Thr Val 
                565                 570                 575     


Asn Cys Ser Gly Ser Ser Ala Thr Phe Ile Pro Ser Ala Leu Thr Pro 
            580                 585                 590         


Leu Asn Ala Gly Thr Asn Tyr Thr Ala Thr Ile Leu Thr Val Asn Asp 
        595                 600                 605             


Ile Val Gly Asn Pro Ile Gly Ala Ala Phe Gly Trp Ser Phe Thr Thr 
    610                 615                 620                 


Gly Ala Ala Pro Asp Val Thr Pro Pro Val Val Thr Ile Gln Asn Leu 
625                 630                 635                 640 


Arg Asn Asn Ser Ile Val Glu Thr Gly Phe Val Ile Gly Thr Ala Thr 
                645                 650                 655     


Asp Ala Gly Thr Ile Thr Ser Val Glu Val Ser Leu Asp Asn Gly Ala 
            660                 665                 670         


Phe Val Pro Ala Thr Gly Thr Asn Pro Trp Lys Phe Lys Leu Pro Ser 
        675                 680                 685             


Asp Ile Asn Thr Trp Lys Gln Asn Ser Gln His Thr Ile Ile Ala Arg 
    690                 695                 700                 


Ala Lys Asp Leu Ala Asn Asn Leu Thr Thr Thr Ala Ala Ile Ser Val 
705                 710                 715                 720 


Arg Lys Gly Asn Asn Lys Asp Ile Asn Gly Asp Gly Tyr Val Asp Leu 
                725                 730                 735     


Val Ser Ala Glu Tyr Gly Gln Gly Leu Leu Tyr Ile Phe His Ser Ser 
            740                 745                 750         


Gly Asn Ala Gly Met Thr Ile Thr Asn Ala Gln Ser Ala Ser Lys Ile 
        755                 760                 765             


Ile Val Gly Val Ala Ala Glu Glu Phe Gly Arg Thr Val Ser Met Gly 
    770                 775                 780                 


Asp Leu Asn Gly Asp Gly Phe Ala Asp Val Ile Ser Gly Ala Pro Gly 
785                 790                 795                 800 


Trp Asn Gly Ala Gln Gly Arg Val Tyr Ile Phe His Ser Ser Gly Asn 
                805                 810                 815     


Ala Gly Val Asn Ile Ser Phe Ser Gly Phe Ala Thr Lys Thr Ile Ser 
            820                 825                 830         


Gly Ala Asn Ala Gly Ala Arg Phe Gly Asp Ser Ile Val Thr Gly Asp 
        835                 840                 845             


Leu Asn Gly Asp Gly Tyr Ala Asp Leu Ala Ser Gly Glu Pro Val Phe 
    850                 855                 860                 


Asn Gly Ser Gln Gly Arg Val Tyr Val Phe His Ser Ala Gly Ala Ala 
865                 870                 875                 880 


Gly Val Thr Gln Ile Asn Ser Ala Ala Ala Asn Ser Thr Leu Thr Gly 
                885                 890                 895     


Glu Asn Ala Thr Asp Arg Phe Gly Tyr Ser Leu Ser Thr Gly Asn Met 
            900                 905                 910         


Asn Gly Asp Asn Phe Ala Asp Leu Ala Ile Gly Ala Pro Gly Tyr Gly 
        915                 920                 925             


Ala Gly Val Gly Gly Gly Phe Val Val Asn Gln Gly Lys Val Tyr Ile 
    930                 935                 940                 


His His Gly Ala Ala Gly Gly Leu Gly Gly Val Ile Thr Thr Leu Thr 
945                 950                 955                 960 


Asn Asp Ser Ala Gly Asn Ala Gly Glu Phe Gly Ile Ser Leu Phe Thr 
                965                 970                 975     


Ala Asp Phe Asn Gly Asp Gly Asn Ser Asp Leu Ala Ile Gly Ser Pro 
            980                 985                 990         


Asn Leu Gly Gly Gly Thr Gly Arg  Val Ser Val Phe Thr  Ser Ala Gly 
        995                 1000                 1005             


Gly Val  Gly Ile Asn Thr Ser  Thr Ile Gly Asn Ala  Pro Leu Met 
    1010                 1015                 1020             


Ile Asn  Gly Thr Ala Val Gly  Asn Ala Phe Gly Ile  Ser Leu Thr 
    1025                 1030                 1035             


Ala Gln  Asp Leu Asn Leu Asp  Gly Arg Pro Asp Leu  Ile Ser Ala 
    1040                 1045                 1050             


Thr Val  Ile Pro Asn Arg Val  Phe Val Phe His Met  Pro Gly Ala 
    1055                 1060                 1065             


Gly Ala  Ile Gly Gly Phe Leu  Thr Thr Gly Asn Ala  Thr Thr Gln 
    1070                 1075                 1080             


Ile Thr  Ser Ala Phe Ala Gly  Ile Gly Val Ser Pro  Asn Ala Pro 
    1085                 1090                 1095             


Lys Thr  Pro Ile Ser Gly Gly  Asp Ile Asn Gly Asp  Gly Phe Pro 
    1100                 1105                 1110             


Asp Leu  Phe Val Gly Gly Ser  Ser Asp Asn Ile Phe  Ile Phe His 
    1115                 1120                 1125             


Ser Ser  Thr Val Gly Thr Gly  Leu Leu Thr Asn Thr  Thr Ala Thr 
    1130                 1135                 1140             


Ala Ala  Gly Ala Ile Thr Ser  Ser Gly Leu Ala Asn  Gly Phe Phe 
    1145                 1150                 1155             


Gly Cys  Ser Val Tyr 
    1160             


<210>  62
<211>  1287
<212>  DNA
<213>  Leptospira interrogans serovar Pomona


<220>
<221>  CDS
<222>  (1)..(1287)

<400>  62
atg agc cta aaa aat aaa aat tat gtt tta tca aaa aaa acc ata ttg         48
Met Ser Leu Lys Asn Lys Asn Tyr Val Leu Ser Lys Lys Thr Ile Leu           
1               5                   10                  15                

att cta ttt tta gta tat ttt gtt ttt ata att tct ttt ttt tct att         96
Ile Leu Phe Leu Val Tyr Phe Val Phe Ile Ile Ser Phe Phe Ser Ile           
            20                  25                  30                    

tac tct cag gat tta agt ata aat caa aat cct aaa cca gaa aag tta        144
Tyr Ser Gln Asp Leu Ser Ile Asn Gln Asn Pro Lys Pro Glu Lys Leu           
        35                  40                  45                        

aaa ggt tct atc aat acg agt ctc aat gag ttt gga atc agt ctt act        192
Lys Gly Ser Ile Asn Thr Ser Leu Asn Glu Phe Gly Ile Ser Leu Thr           
    50                  55                  60                            

gat gac gga aat att tta tat ttc tat tct aaa aga caa aat tca aat        240
Asp Asp Gly Asn Ile Leu Tyr Phe Tyr Ser Lys Arg Gln Asn Ser Asn           
65                  70                  75                  80            

tat aca gac att tat aag tca act cga acg aaa gat gaa tgg aca caa        288
Tyr Thr Asp Ile Tyr Lys Ser Thr Arg Thr Lys Asp Glu Trp Thr Gln           
                85                  90                  95                

gga gag gaa att gaa gtt cta aat tca aac ttt gac gac caa agt cct        336
Gly Glu Glu Ile Glu Val Leu Asn Ser Asn Phe Asp Asp Gln Ser Pro           
            100                 105                 110                   

ttc att tta aac cga gaa gaa gga att ctt ttt tca tct aat aga gat        384
Phe Ile Leu Asn Arg Glu Glu Gly Ile Leu Phe Ser Ser Asn Arg Asp           
        115                 120                 125                       

ggt gcg acc gaa ttc caa ttt gca aat gga aaa atc gga gtt tct aga        432
Gly Ala Thr Glu Phe Gln Phe Ala Asn Gly Lys Ile Gly Val Ser Arg           
    130                 135                 140                           

gat att tat ttt tct aaa aaa ata aat tct tct tgg aca gaa ccg gtt        480
Asp Ile Tyr Phe Ser Lys Lys Ile Asn Ser Ser Trp Thr Glu Pro Val           
145                 150                 155                 160           

ctt ctt cct aga gcc gtg aat acg gaa gaa atc gaa gaa aat ccg ttt        528
Leu Leu Pro Arg Ala Val Asn Thr Glu Glu Ile Glu Glu Asn Pro Phe           
                165                 170                 175               

cta ttt aat aat aga ttg tat ttt acc cgt tat cct ttt ggg caa gtt        576
Leu Phe Asn Asn Arg Leu Tyr Phe Thr Arg Tyr Pro Phe Gly Gln Val           
            180                 185                 190                   

tca gaa gcg gac att ttc gtt tct gtt tat aaa aat aac act tgg gaa        624
Ser Glu Ala Asp Ile Phe Val Ser Val Tyr Lys Asn Asn Thr Trp Glu           
        195                 200                 205                       

aaa gca atg agc ctc cct gat ccg att aac acc gtt tat tcg gaa att        672
Lys Ala Met Ser Leu Pro Asp Pro Ile Asn Thr Val Tyr Ser Glu Ile           
    210                 215                 220                           

gcg gct aca att agt aaa gat gga aag acg att tat ttt tct tct aac        720
Ala Ala Thr Ile Ser Lys Asp Gly Lys Thr Ile Tyr Phe Ser Ser Asn           
225                 230                 235                 240           

cgt ccg ggg ggt ttt ggc ggt tat gat ttg tat aag tct act tta ctt        768
Arg Pro Gly Gly Phe Gly Gly Tyr Asp Leu Tyr Lys Ser Thr Leu Leu           
                245                 250                 255               

gaa aac gga aat tat tcc gaa ccg att aat ctt gga ccc gaa att aac        816
Glu Asn Gly Asn Tyr Ser Glu Pro Ile Asn Leu Gly Pro Glu Ile Asn           
            260                 265                 270                   

act acc gga gat gag gct ttt ttt ctg gaa aca aac gat aga aag aca        864
Thr Thr Gly Asp Glu Ala Phe Phe Leu Glu Thr Asn Asp Arg Lys Thr           
        275                 280                 285                       

ttc tat ttt tgt aga agg aaa gaa cgc gat tat gat att tat tct atc        912
Phe Tyr Phe Cys Arg Arg Lys Glu Arg Asp Tyr Asp Ile Tyr Ser Ile           
    290                 295                 300                           

gtt tct aac ccg ttt caa gaa cta gaa aaa gga aaa tct att tct ttg        960
Val Ser Asn Pro Phe Gln Glu Leu Glu Lys Gly Lys Ser Ile Ser Leu           
305                 310                 315                 320           

gat agt atc cat ttt tct ttg ggc tct tat gaa att ctc gaa aat tct       1008
Asp Ser Ile His Phe Ser Leu Gly Ser Tyr Glu Ile Leu Glu Asn Ser           
                325                 330                 335               

ttt tca att tta gat aat ttg aat tct tat ctt aag gaa aat tta aat       1056
Phe Ser Ile Leu Asp Asn Leu Asn Ser Tyr Leu Lys Glu Asn Leu Asn           
            340                 345                 350                   

ata aaa atc aaa atc acc ggc cat acc gat ctt aat gga gat tcc cag       1104
Ile Lys Ile Lys Ile Thr Gly His Thr Asp Leu Asn Gly Asp Ser Gln           
        355                 360                 365                       

gac aac ctt att ctc agc cgt aat cgt gca aat gca gta aag gat tat       1152
Asp Asn Leu Ile Leu Ser Arg Asn Arg Ala Asn Ala Val Lys Asp Tyr           
    370                 375                 380                           

tta gtt aaa agg gga atc gat tct caa aga att atc acg gat ggg aaa       1200
Leu Val Lys Arg Gly Ile Asp Ser Gln Arg Ile Ile Thr Asp Gly Lys           
385                 390                 395                 400           

ggt agt tcg gag cca att gtt cct atg aaa aat cca gag acg gat tat       1248
Gly Ser Ser Glu Pro Ile Val Pro Met Lys Asn Pro Glu Thr Asp Tyr           
                405                 410                 415               

aaa aat aga aga acc gaa ttt cag att atc agt cgt tag                   1287
Lys Asn Arg Arg Thr Glu Phe Gln Ile Ile Ser Arg                           
            420                 425                                       


<210>  63
<211>  428
<212>  PRT
<213>  Leptospira interrogans serovar Pomona

<400>  63

Met Ser Leu Lys Asn Lys Asn Tyr Val Leu Ser Lys Lys Thr Ile Leu 
1               5                   10                  15      


Ile Leu Phe Leu Val Tyr Phe Val Phe Ile Ile Ser Phe Phe Ser Ile 
            20                  25                  30          


Tyr Ser Gln Asp Leu Ser Ile Asn Gln Asn Pro Lys Pro Glu Lys Leu 
        35                  40                  45              


Lys Gly Ser Ile Asn Thr Ser Leu Asn Glu Phe Gly Ile Ser Leu Thr 
    50                  55                  60                  


Asp Asp Gly Asn Ile Leu Tyr Phe Tyr Ser Lys Arg Gln Asn Ser Asn 
65                  70                  75                  80  


Tyr Thr Asp Ile Tyr Lys Ser Thr Arg Thr Lys Asp Glu Trp Thr Gln 
                85                  90                  95      


Gly Glu Glu Ile Glu Val Leu Asn Ser Asn Phe Asp Asp Gln Ser Pro 
            100                 105                 110         


Phe Ile Leu Asn Arg Glu Glu Gly Ile Leu Phe Ser Ser Asn Arg Asp 
        115                 120                 125             


Gly Ala Thr Glu Phe Gln Phe Ala Asn Gly Lys Ile Gly Val Ser Arg 
    130                 135                 140                 


Asp Ile Tyr Phe Ser Lys Lys Ile Asn Ser Ser Trp Thr Glu Pro Val 
145                 150                 155                 160 


Leu Leu Pro Arg Ala Val Asn Thr Glu Glu Ile Glu Glu Asn Pro Phe 
                165                 170                 175     


Leu Phe Asn Asn Arg Leu Tyr Phe Thr Arg Tyr Pro Phe Gly Gln Val 
            180                 185                 190         


Ser Glu Ala Asp Ile Phe Val Ser Val Tyr Lys Asn Asn Thr Trp Glu 
        195                 200                 205             


Lys Ala Met Ser Leu Pro Asp Pro Ile Asn Thr Val Tyr Ser Glu Ile 
    210                 215                 220                 


Ala Ala Thr Ile Ser Lys Asp Gly Lys Thr Ile Tyr Phe Ser Ser Asn 
225                 230                 235                 240 


Arg Pro Gly Gly Phe Gly Gly Tyr Asp Leu Tyr Lys Ser Thr Leu Leu 
                245                 250                 255     


Glu Asn Gly Asn Tyr Ser Glu Pro Ile Asn Leu Gly Pro Glu Ile Asn 
            260                 265                 270         


Thr Thr Gly Asp Glu Ala Phe Phe Leu Glu Thr Asn Asp Arg Lys Thr 
        275                 280                 285             


Phe Tyr Phe Cys Arg Arg Lys Glu Arg Asp Tyr Asp Ile Tyr Ser Ile 
    290                 295                 300                 


Val Ser Asn Pro Phe Gln Glu Leu Glu Lys Gly Lys Ser Ile Ser Leu 
305                 310                 315                 320 


Asp Ser Ile His Phe Ser Leu Gly Ser Tyr Glu Ile Leu Glu Asn Ser 
                325                 330                 335     


Phe Ser Ile Leu Asp Asn Leu Asn Ser Tyr Leu Lys Glu Asn Leu Asn 
            340                 345                 350         


Ile Lys Ile Lys Ile Thr Gly His Thr Asp Leu Asn Gly Asp Ser Gln 
        355                 360                 365             


Asp Asn Leu Ile Leu Ser Arg Asn Arg Ala Asn Ala Val Lys Asp Tyr 
    370                 375                 380                 


Leu Val Lys Arg Gly Ile Asp Ser Gln Arg Ile Ile Thr Asp Gly Lys 
385                 390                 395                 400 


Gly Ser Ser Glu Pro Ile Val Pro Met Lys Asn Pro Glu Thr Asp Tyr 
                405                 410                 415     


Lys Asn Arg Arg Thr Glu Phe Gln Ile Ile Ser Arg 
            420                 425             


<210>  64
<211>  1152
<212>  DNA
<213>  Leptospira interrogans serovar Pomona


<220>
<221>  CDS
<222>  (1)..(1152)

<400>  64
atg gcg aag aaa gaa aac tac tat att act atc aaa ggt aga aaa tat         48
Met Ala Lys Lys Glu Asn Tyr Tyr Ile Thr Ile Lys Gly Arg Lys Tyr           
1               5                   10                  15                

gat cgt aag ttg atc cag ctc gcg gaa gag ttc act tcc ggt aaa cgg         96
Asp Arg Lys Leu Ile Gln Leu Ala Glu Glu Phe Thr Ser Gly Lys Arg           
            20                  25                  30                    

gac ggt aag att tcg atc aac gac gca aaa cgt ctt tta aaa att gtc        144
Asp Gly Lys Ile Ser Ile Asn Asp Ala Lys Arg Leu Leu Lys Ile Val           
        35                  40                  45                        

aag gat aac aac gct tat acg gat ata gaa aaa cat acg atc gaa tac        192
Lys Asp Asn Asn Ala Tyr Thr Asp Ile Glu Lys His Thr Ile Glu Tyr           
    50                  55                  60                            

att cgt gaa aac tat aag ttt acc gaa aaa tcg gac gaa tgg ttc cgt        240
Ile Arg Glu Asn Tyr Lys Phe Thr Glu Lys Ser Asp Glu Trp Phe Arg           
65                  70                  75                  80            

tca gaa atc cgt aaa tgg gcc gct aaa aaa gtg caa gaa gca aaa aag        288
Ser Glu Ile Arg Lys Trp Ala Ala Lys Lys Val Gln Glu Ala Lys Lys           
                85                  90                  95                

aaa agt gat gtg gaa tcc atc cta gtc gat gat tct gaa gcg ccg gaa        336
Lys Ser Asp Val Glu Ser Ile Leu Val Asp Asp Ser Glu Ala Pro Glu           
            100                 105                 110                   

ata aat ttt cct tcc agt tgg gga gaa gac aaa acc gaa gtt gtt gaa        384
Ile Asn Phe Pro Ser Ser Trp Gly Glu Asp Lys Thr Glu Val Val Glu           
        115                 120                 125                       

att aca caa acc tct aaa ata gat tgg aga gaa aat tca aat ttt tca        432
Ile Thr Gln Thr Ser Lys Ile Asp Trp Arg Glu Asn Ser Asn Phe Ser           
    130                 135                 140                           

tcc gca acg tct cac tct aaa aaa aat aaa aag atc att cca act tta        480
Ser Ala Thr Ser His Ser Lys Lys Asn Lys Lys Ile Ile Pro Thr Leu           
145                 150                 155                 160           

att ttt ctt tct ggt ttt ttg att ctt gta ggt tta gtt tat ttt ttt        528
Ile Phe Leu Ser Gly Phe Leu Ile Leu Val Gly Leu Val Tyr Phe Phe           
                165                 170                 175               

cga acc tta ttt tat aag gaa gac ttg gaa caa gta gta aaa acg aat        576
Arg Thr Leu Phe Tyr Lys Glu Asp Leu Glu Gln Val Val Lys Thr Asn           
            180                 185                 190                   

tct gag att gtc tct aat tca aaa gaa aaa caa tcc gac gtt tcg ata        624
Ser Glu Ile Val Ser Asn Ser Lys Glu Lys Gln Ser Asp Val Ser Ile           
        195                 200                 205                       

gaa aaa gca gaa tct aca aag gaa gtt cga aag aaa aac gta aga tct        672
Glu Lys Ala Glu Ser Thr Lys Glu Val Arg Lys Lys Asn Val Arg Ser           
    210                 215                 220                           

aaa aaa gaa gaa tcg gaa att cca aaa aat gct ctt aca att cta aaa        720
Lys Lys Glu Glu Ser Glu Ile Pro Lys Asn Ala Leu Thr Ile Leu Lys           
225                 230                 235                 240           

cct caa acc gga aag aag tta gaa tct aaa tcc tta ttc tct tcg ttg        768
Pro Gln Thr Gly Lys Lys Leu Glu Ser Lys Ser Leu Phe Ser Ser Leu           
                245                 250                 255               

aca aat caa aat tcc aca gaa gaa ttt tct tcc aat cct caa ttt aga        816
Thr Asn Gln Asn Ser Thr Glu Glu Phe Ser Ser Asn Pro Gln Phe Arg           
            260                 265                 270                   

gaa att gaa tcc aat gta att cgt ttt gaa aaa aac agc att caa att        864
Glu Ile Glu Ser Asn Val Ile Arg Phe Glu Lys Asn Ser Ile Gln Ile           
        275                 280                 285                       

cat aaa gaa tcg aga cca agt ctc aac cgt ttg gct cgc tgg atg aaa        912
His Lys Glu Ser Arg Pro Ser Leu Asn Arg Leu Ala Arg Trp Met Lys           
    290                 295                 300                           

cag gat tct tcg atc cga gtc aaa gtt atc ggt cat act tct tta gag        960
Gln Asp Ser Ser Ile Arg Val Lys Val Ile Gly His Thr Ser Leu Glu           
305                 310                 315                 320           

ggt agc gaa gac gcc aat caa aaa gtt tct ctt ctt cgt gca caa acg       1008
Gly Ser Glu Asp Ala Asn Gln Lys Val Ser Leu Leu Arg Ala Gln Thr           
                325                 330                 335               

gtt cga aat tat atc gcc ggg aat ggc att tcc aaa gat cgt ttt gag       1056
Val Arg Asn Tyr Ile Ala Gly Asn Gly Ile Ser Lys Asp Arg Phe Glu           
            340                 345                 350                   

att att ccc aaa ggc gca agc gtt cct att ggc gat aat tct aaa gaa       1104
Ile Ile Pro Lys Gly Ala Ser Val Pro Ile Gly Asp Asn Ser Lys Glu           
        355                 360                 365                       

gag ggg aag gaa atg aat cgt aga gtg gaa ctt aga atc tat aat tga       1152
Glu Gly Lys Glu Met Asn Arg Arg Val Glu Leu Arg Ile Tyr Asn               
    370                 375                 380                           


<210>  65
<211>  383
<212>  PRT
<213>  Leptospira interrogans serovar Pomona

<400>  65

Met Ala Lys Lys Glu Asn Tyr Tyr Ile Thr Ile Lys Gly Arg Lys Tyr 
1               5                   10                  15      


Asp Arg Lys Leu Ile Gln Leu Ala Glu Glu Phe Thr Ser Gly Lys Arg 
            20                  25                  30          


Asp Gly Lys Ile Ser Ile Asn Asp Ala Lys Arg Leu Leu Lys Ile Val 
        35                  40                  45              


Lys Asp Asn Asn Ala Tyr Thr Asp Ile Glu Lys His Thr Ile Glu Tyr 
    50                  55                  60                  


Ile Arg Glu Asn Tyr Lys Phe Thr Glu Lys Ser Asp Glu Trp Phe Arg 
65                  70                  75                  80  


Ser Glu Ile Arg Lys Trp Ala Ala Lys Lys Val Gln Glu Ala Lys Lys 
                85                  90                  95      


Lys Ser Asp Val Glu Ser Ile Leu Val Asp Asp Ser Glu Ala Pro Glu 
            100                 105                 110         


Ile Asn Phe Pro Ser Ser Trp Gly Glu Asp Lys Thr Glu Val Val Glu 
        115                 120                 125             


Ile Thr Gln Thr Ser Lys Ile Asp Trp Arg Glu Asn Ser Asn Phe Ser 
    130                 135                 140                 


Ser Ala Thr Ser His Ser Lys Lys Asn Lys Lys Ile Ile Pro Thr Leu 
145                 150                 155                 160 


Ile Phe Leu Ser Gly Phe Leu Ile Leu Val Gly Leu Val Tyr Phe Phe 
                165                 170                 175     


Arg Thr Leu Phe Tyr Lys Glu Asp Leu Glu Gln Val Val Lys Thr Asn 
            180                 185                 190         


Ser Glu Ile Val Ser Asn Ser Lys Glu Lys Gln Ser Asp Val Ser Ile 
        195                 200                 205             


Glu Lys Ala Glu Ser Thr Lys Glu Val Arg Lys Lys Asn Val Arg Ser 
    210                 215                 220                 


Lys Lys Glu Glu Ser Glu Ile Pro Lys Asn Ala Leu Thr Ile Leu Lys 
225                 230                 235                 240 


Pro Gln Thr Gly Lys Lys Leu Glu Ser Lys Ser Leu Phe Ser Ser Leu 
                245                 250                 255     


Thr Asn Gln Asn Ser Thr Glu Glu Phe Ser Ser Asn Pro Gln Phe Arg 
            260                 265                 270         


Glu Ile Glu Ser Asn Val Ile Arg Phe Glu Lys Asn Ser Ile Gln Ile 
        275                 280                 285             


His Lys Glu Ser Arg Pro Ser Leu Asn Arg Leu Ala Arg Trp Met Lys 
    290                 295                 300                 


Gln Asp Ser Ser Ile Arg Val Lys Val Ile Gly His Thr Ser Leu Glu 
305                 310                 315                 320 


Gly Ser Glu Asp Ala Asn Gln Lys Val Ser Leu Leu Arg Ala Gln Thr 
                325                 330                 335     


Val Arg Asn Tyr Ile Ala Gly Asn Gly Ile Ser Lys Asp Arg Phe Glu 
            340                 345                 350         


Ile Ile Pro Lys Gly Ala Ser Val Pro Ile Gly Asp Asn Ser Lys Glu 
        355                 360                 365             


Glu Gly Lys Glu Met Asn Arg Arg Val Glu Leu Arg Ile Tyr Asn 
    370                 375                 380             


<210>  66
<211>  549
<212>  DNA
<213>  Leptospira interrogans serovar Pomona


<220>
<221>  CDS
<222>  (1)..(549)

<400>  66
atg aaa tat aaa ata att tta att tta tca cta atg tta ttt ctt ttc         48
Met Lys Tyr Lys Ile Ile Leu Ile Leu Ser Leu Met Leu Phe Leu Phe           
1               5                   10                  15                

gtt tcc tgt ccg gat gaa aaa aaa gaa aat gaa ttg agt act tat att         96
Val Ser Cys Pro Asp Glu Lys Lys Glu Asn Glu Leu Ser Thr Tyr Ile           
            20                  25                  30                    

tta tat agt gtt ctc ata aac gca act act caa tac gat tgt gtt act        144
Leu Tyr Ser Val Leu Ile Asn Ala Thr Thr Gln Tyr Asp Cys Val Thr           
        35                  40                  45                        

agt tcg gaa gta gta tca gac tct tat aac aaa aca aca ata acc ttc        192
Ser Ser Glu Val Val Ser Asp Ser Tyr Asn Lys Thr Thr Ile Thr Phe           
    50                  55                  60                            

gaa aat aaa cct caa tat tac aat tca ccc agt gga aat gta gtt cca        240
Glu Asn Lys Pro Gln Tyr Tyr Asn Ser Pro Ser Gly Asn Val Val Pro           
65                  70                  75                  80            

aaa gca att atg ccg att ttg att aaa aag ggg cag aca att caa gta        288
Lys Ala Ile Met Pro Ile Leu Ile Lys Lys Gly Gln Thr Ile Gln Val           
                85                  90                  95                

tcc agt ata acg act aac gtt aag tat gaa gcg aca aac caa gac tta        336
Ser Ser Ile Thr Thr Asn Val Lys Tyr Glu Ala Thr Asn Gln Asp Leu           
            100                 105                 110                   

act ttt ctt ttt aga aaa gat ggt tgt cac ggt aca aac tcc gaa att        384
Thr Phe Leu Phe Arg Lys Asp Gly Cys His Gly Thr Asn Ser Glu Ile           
        115                 120                 125                       

gca acc tat gca gga gct act aat aca aat gtt ttt tta gga aac aca        432
Ala Thr Tyr Ala Gly Ala Thr Asn Thr Asn Val Phe Leu Gly Asn Thr           
    130                 135                 140                           

aat act gtt agc tta act caa ttt aaa ttt acc gcc gac tat aat ggg        480
Asn Thr Val Ser Leu Thr Gln Phe Lys Phe Thr Ala Asp Tyr Asn Gly           
145                 150                 155                 160           

att ata cta atc gtt ggg aaa aac cta ggt gca agt tta cct gga gat        528
Ile Ile Leu Ile Val Gly Lys Asn Leu Gly Ala Ser Leu Pro Gly Asp           
                165                 170                 175               

att cgt gtg aat gta ttt taa                                            549
Ile Arg Val Asn Val Phe                                                   
            180                                                           


<210>  67
<211>  182
<212>  PRT
<213>  Leptospira interrogans serovar Pomona

<400>  67

Met Lys Tyr Lys Ile Ile Leu Ile Leu Ser Leu Met Leu Phe Leu Phe 
1               5                   10                  15      


Val Ser Cys Pro Asp Glu Lys Lys Glu Asn Glu Leu Ser Thr Tyr Ile 
            20                  25                  30          


Leu Tyr Ser Val Leu Ile Asn Ala Thr Thr Gln Tyr Asp Cys Val Thr 
        35                  40                  45              


Ser Ser Glu Val Val Ser Asp Ser Tyr Asn Lys Thr Thr Ile Thr Phe 
    50                  55                  60                  


Glu Asn Lys Pro Gln Tyr Tyr Asn Ser Pro Ser Gly Asn Val Val Pro 
65                  70                  75                  80  


Lys Ala Ile Met Pro Ile Leu Ile Lys Lys Gly Gln Thr Ile Gln Val 
                85                  90                  95      


Ser Ser Ile Thr Thr Asn Val Lys Tyr Glu Ala Thr Asn Gln Asp Leu 
            100                 105                 110         


Thr Phe Leu Phe Arg Lys Asp Gly Cys His Gly Thr Asn Ser Glu Ile 
        115                 120                 125             


Ala Thr Tyr Ala Gly Ala Thr Asn Thr Asn Val Phe Leu Gly Asn Thr 
    130                 135                 140                 


Asn Thr Val Ser Leu Thr Gln Phe Lys Phe Thr Ala Asp Tyr Asn Gly 
145                 150                 155                 160 


Ile Ile Leu Ile Val Gly Lys Asn Leu Gly Ala Ser Leu Pro Gly Asp 
                165                 170                 175     


Ile Arg Val Asn Val Phe 
            180         


