                         SEQUENCE LISTING

<110>  Medarex Inc.
       Terrett, Jonathan A.
       Pogue, Sarah L.
       Toy, Kristopher
       Yang, Lan
       Rao-Naik, Chetana
       Chen, Bingliang
 
<120>  HUMAN ANTIBODIES THAT BIND MESOTHELIN, AND USES THEREOF

<130>  0192PC

<140>  WO 00/000000
<141>  2008-10-01

<150>  US 60/976626
<151>  2007-10-01

<150>  US 60/991,692
<151>  2007-11-30

<150>  US 61/077,397
<151>  2008-07-01

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  1

Ile Tyr Gly Met His 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Tyr Gly Met His 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  3

Arg Tyr Trp Met Ser 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Ile Trp Tyr Asp Gly Ser His Glu Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  5

Val Leu Trp Tyr Asp Gly Ser His Glu Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Ile Lys Gln Ala Gly Ser Glu Lys Thr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Gly Asp Tyr Tyr Asp Ser Gly Ser Pro Leu Asp Tyr 
1               5                   10              


<210>  8
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Gly Asp Tyr Tyr Asp Ser Gly Ser Pro Leu Asp Tyr 
1               5                   10              


<210>  9
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Gly Ala Tyr Tyr Tyr Asp Ser Ala Ser Tyr Tyr Pro Tyr Tyr Tyr 
1               5                   10                  15      


Tyr Tyr Ser Met Asp Val 
            20          


<210>  10
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  10

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  11
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  11

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  12
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  13
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Gln Tyr Gly Ser Ser Gln Tyr Thr 
1               5                   


<210>  19
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Val Tyr Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser His Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asp Tyr Tyr Asp Ser Gly Ser Pro Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  20
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Val His Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ile Thr Phe Arg Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Leu Trp Tyr Asp Gly Ser His Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asp Tyr Tyr Asp Ser Gly Ser Pro Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  21
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  21

Glu Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Gln Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Lys Gln Ala Gly Ser Glu Lys Thr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ala Tyr Tyr Tyr Asp Ser Ala Ser Tyr Tyr Pro Tyr 
            100                 105                 110         


Tyr Tyr Tyr Tyr Ser Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  22
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  23
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  23

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  24
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  24

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Gln 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  25
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  25
caggtgtacc tggtggagtc tgggggaggc gtggtccagc ccgggaggtc cctgagactc       60

tcctgtgcag cgtctggaat caccttcagt atctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtca tgaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgctaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatggc      300

gattattatg attcggggag tcctcttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  26
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  26
caggtgcacc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgtag cgtctggaat caccttcagg atctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt ttatggtatg atggaagtca tgaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctatat      240

ctgcaaatga acagcctgag agccgaggac acggctatat attactgtgc gagagatggc      300

gattactatg attcggggag tcctcttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  27
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  27
gaggttcacc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agatactgga tgagctgggt ccgccaggct      120

caagggaaag ggctggagtg ggtggccagc ataaagcaag ctggaagtga gaaaacctat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtct      240

ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagggagggg      300

gcatattact atgattcggc gagttattac ccttactact actactacag tatggacgtc      360

tggggccaag ggaccacggt caccgtctcc tca                                   393


<210>  28
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  28
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggccgctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  29
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  29
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggccgctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  30
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  30
gtgttgacgc agtctccagg caccctgtct ttgtctccag gggaaagagc caccctctcc       60

tgcagggcca gtcagagtgt tagcagcagc tacttagcct ggtaccagca gaaacctggc      120

caggctccca ggctcctcat ctatggtgca tccagcaggg ccactggcat cccagacagg      180

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagact ggagcctgaa      240

gattttgcag tgtattactg tcagcagtat ggtagctcac agtacacttt tggccagggg      300

accaagctgg agatcaaa                                                    318


<210>  31
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  32
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  33
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro 
                85                  90                  95  


<210>  34
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  34

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser 
                85                  90                  95  


<210>  35
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  35

Asp Gly Asp Tyr Tyr Asp Ser Gly Ser Pro Leu 
1               5                   10      


<210>  36
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  36

Asp Gly Asp Tyr Tyr Asp Ser Gly Ser Pro Leu 
1               5                   10      


<210>  37
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  37

Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210>  38
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  38

Glu Gly Ala Tyr Tyr Tyr Asp Ser Ala Ser Tyr Tyr Pro 
1               5                   10              


<210>  39
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  39

Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10          


<210>  40
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide conjugate sequence

<400>  40

Ala Leu Ala Leu 
1               


<210>  41
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide conjugate sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = Beta-alanine

<400>  41

Xaa Leu Ala Leu 
1               


<210>  42
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide conjugate sequence

<400>  42

Gly Phe Leu Gly 
1               


<210>  43
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide conjugate sequence

<400>  43

Leu Leu Gly Leu 
1               


