                         SEQUENCE LISTING

<110>  United States Army Medical Research and Materiel Command
 
<120>  CR-2 Binding Peptide p28 as Molecular Adjuvant for DNA Vaccines

<130>  WRAIR 07-50PCT

<150>  US 60/998,460
<151>  2007-10-03

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  The forward primer of a murine C3d DNA fragment

<400>  1
gggagatcta cccccgcagg ctctggg                                           27


<210>  2
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  The reverse primer of a murine C3d DNA fragment.

<400>  2
ggggatccgg ggaggtggaa ggacacatcc                                        30


<210>  3
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Linker oligonucleotides used in creating pCI-TPA/2C3n plasmid

<400>  3
gatctggagg aggaggctcc ggaggaggag gctccggatc cgaattca                    48


<210>  4
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Linker oligonucleotides used in constructing pCI-TPA/2C3n plasbid

<400>  4
agcttgaatt cggatccgga gcctcctcct ccggagcctc ctcctcca                    48


<210>  5
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for PCR of CSP N-T 1311

<400>  5
gtcagcggat ccgatggac                                                    19


<210>  6
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer of CSP N-T 1370

<400>  6
tggtggtggg gatccttgtt tcaatttatt attacgctc                              39


<210>  7
<211>  53
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for PCR of CSP C-T 1809

<400>  7
caaccaggat ccggtggtaa taacaataac aaaaataata ataatgacga ttc              53


<210>  8
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse PCR primer for CSP C-T 2072

<400>  8
tcttcaggat ccacttgaac                                                   20


<210>  9
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Stop, sense cloning oligonucleotides used in constructing 
       pCI-TPA, stop, -EEF motif

<400>  9
ctagcggatc ctgaa                                                        15


<210>  10
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Stop, nonsense oligonucleotides used in constructing pCI-TPA, 
       stop, -EEF motif

<400>  10
gatcttcagg atccg                                                        15


<210>  11
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Adapter, sense oligonucleotide used in constructing CSP +A 
       plasmid

<400>  11
ttaggatccg aggaattctg a                                                 21


<210>  12
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Adapter, nonsense oligonucleotides used in constructing CSP +A 
       plasmid

<400>  12
gatctcagaa ttcctcggat cctaaat                                           27


<210>  13
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  PCR, sense oligonucleotide used to replicate pCI-TPA(PbCSP6618) 
       plasmid

<400>  13
gctagcacat gtggttctgg                                                   20


<210>  14
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  PCR, nonsense oligonucleotide used to replicate 
       pCI-TPA(PbCSP6618) plasmid

<400>  14
ttacctattt acaagttcac cttaaggagt ctagaat                                37


<210>  15
<211>  65
<212>  DNA
<213>  Artificial

<220>
<223>  primer for p28 fragment of C3d from pCI-CSP-3xC3d construct

<400>  15
aatgcacaga tctggaggcg gcggttcagg aggcggcggt agcaagtttc tgaacacagc       60

caaag                                                                   65


<210>  16
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  primer for p28 fragment of C3d from pCI-CSP-3xC3d construct

<400>  16
aatgcgaatt cttaggatcc ggcgtaggat gtggcctcta                             40


<210>  17
<211>  11
<212>  DNA
<213>  Artificial

<220>
<223>  Linker oligonucleotides used to consruct WRG-6518 vector

<400>  17
cggatccgcc g                                                            11


<210>  18
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic mimic of the tissue plasminogen activator leader 
       sequence

<400>  18
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt       60

tcggctagc                                                               69


<210>  19
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  japcr19 primer

<400>  19
gtcgctccaa gcttgctagc caatatgtca cagtctttta tgg                         43


<210>  20
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  3' primer for sgp110 (hkpcr2)

<400>  20
cccgggatcc tatgcgggcg ccaggccaat cggagtgatc tctactaatt t                51


<210>  21
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  3' primer for sgp130 (jw8)

<400>  21
cgggatccta tgcgggcgcc aggtcaaacc aattgcc                                37


<210>  22
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  PCR 5' primer to amplify hTPA/CSP insert in WRG-6518

<400>  22
gggctcgaga tggatgcaat gaag                                              24


<210>  23
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense PCR primer to amplify the hTPA/SCP insert in WRG-6518

<400>  23
cccgcggccg cttaattaaa gaatactaat actaat                                 36


<210>  24
<211>  24
<212>  PRT
<213>  Plasmodium berghei

<400>  24

Asp Pro Pro Pro Pro Asn Pro Asn Asp Pro Pro Pro Pro Asn Pro Asn 
1               5                   10                  15      


Asp Pro Pro Pro Pro Asn Pro Asn 
            20                  


<210>  25
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  25

Lys Phe Leu Thr Thr Ala Lys Asp Lys Asn Arg Trp Glu Asp Pro Gly 
1               5                   10                  15      


Lys Gln Leu Tyr Asn Val Glu Ala Thr Ser Tyr Ala 
            20                  25              


<210>  26
<211>  84
<212>  DNA
<213>  Mus musculus

<400>  26
aagtttctga acacagccaa agatcggaac cgctgggagg agcctgacca gcagctctac       60

aacgtagagg ccacatccta cgcc                                              84


<210>  27
<211>  1662
<212>  PRT
<213>  Mus musculus

<400>  27

Met Gly Pro Ala Ser Gly Ser Gln Leu Leu Val Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ser Ser Pro Leu Ala Leu Gly Ile Pro Met Tyr Ser Ile Ile Thr 
            20                  25                  30          


Pro Asn Val Leu Arg Leu Glu Ser Glu Glu Thr Ile Val Leu Glu Ala 
        35                  40                  45              


His Asp Ala Gln Gly Asp Ile Pro Val Thr Val Thr Val Gln Asp Phe 
    50                  55                  60                  


Leu Lys Arg Gln Val Leu Ser Glu Lys Thr Val Leu Thr Gly Ala Ser 
65                  70                  75                  80  


Gly His Leu Arg Ser Val Ser Ile Lys Ile Pro Ala Ser Lys Glu Phe 
                85                  90                  95      


Asn Ser Asp Lys Glu Gly His Lys Tyr Val Thr Val Val Ala Asn Phe 
            100                 105                 110         


Gly Glu Thr Val Val Glu Lys Ala Val Met Val Ser Phe Gln Ser Gly 
        115                 120                 125             


Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 
    130                 135                 140                 


Val Leu Tyr Arg Ile Phe Thr Val Asp Asn Asn Leu Leu Pro Val Gly 
145                 150                 155                 160 


Lys Thr Val Val Ile Leu Ile Glu Thr Pro Asp Gly Ile Pro Val Lys 
                165                 170                 175     


Arg Asp Ile Leu Ser Ser Asn Asn Gln His Gly Ile Leu Pro Leu Ser 
            180                 185                 190         


Trp Asn Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 
        195                 200                 205             


Phe Tyr Glu His Ala Pro Lys Gln Ile Phe Ser Ala Glu Phe Glu Val 
    210                 215                 220                 


Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Arg Val Glu Pro Thr Glu 
225                 230                 235                 240 


Thr Phe Tyr Tyr Ile Asp Asp Pro Asn Gly Leu Glu Val Ser Ile Ile 
                245                 250                 255     


Ala Lys Phe Leu Tyr Gly Lys Asn Val Asp Gly Thr Ala Phe Val Ile 
            260                 265                 270         


Phe Gly Val Gln Asp Gly Asp Lys Lys Ile Ser Leu Ala His Ser Leu 
        275                 280                 285             


Thr Arg Val Val Ile Glu Asp Gly Val Gly Asp Ala Val Leu Thr Arg 
    290                 295                 300                 


Lys Val Leu Met Glu Gly Val Arg Pro Ser Asn Ala Asp Ala Leu Val 
305                 310                 315                 320 


Gly Lys Ser Leu Tyr Val Ser Val Thr Val Ile Leu His Ser Gly Ser 
                325                 330                 335     


Asp Met Val Glu Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 
            340                 345                 350         


Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Phe Phe Lys Pro Ala Met 
        355                 360                 365             


Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 
    370                 375                 380                 


Ser Lys Val Leu Val Val Thr Gln Gly Ser Asn Ala Lys Ala Leu Thr 
385                 390                 395                 400 


Gln Asp Asp Gly Val Ala Lys Leu Ser Ile Asn Thr Pro Asn Ser Arg 
                405                 410                 415     


Gln Pro Leu Thr Ile Thr Val Arg Thr Lys Lys Asp Thr Leu Pro Glu 
            420                 425                 430         


Ser Arg Gln Ala Thr Lys Thr Met Glu Ala His Pro Tyr Ser Thr Met 
        435                 440                 445             


His Asn Ser Asn Asn Tyr Leu His Leu Ser Val Ser Arg Met Glu Leu 
    450                 455                 460                 


Lys Pro Gly Asp Asn Leu Asn Val Asn Phe His Leu Arg Thr Asp Pro 
465                 470                 475                 480 


Gly His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Val Met Asn Lys 
                485                 490                 495     


Gly Lys Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln Asp 
            500                 505                 510         


Leu Val Val Leu Ser Leu Pro Ile Thr Pro Glu Phe Ile Pro Ser Phe 
        515                 520                 525             


Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg Glu 
    530                 535                 540                 


Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Ile Gly 
545                 550                 555                 560 


Thr Leu Val Val Lys Gly Asp Pro Arg Asp Asn His Leu Ala Pro Gly 
                565                 570                 575     


Gln Gln Thr Thr Leu Arg Ile Glu Gly Asn Gln Gly Ala Arg Val Gly 
            580                 585                 590         


Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys Asn Lys 
        595                 600                 605             


Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp Ile Gly 
    610                 615                 620                 


Cys Thr Pro Gly Ser Gly Lys Asn Tyr Ala Gly Val Phe Met Asp Ala 
625                 630                 635                 640 


Gly Leu Ala Phe Lys Thr Ser Gln Gly Leu Gln Thr Glu Gln Arg Ala 
                645                 650                 655     


Asp Leu Glu Cys Thr Lys Pro Ala Ala Arg Arg Arg Arg Ser Val Gln 
            660                 665                 670         


Leu Met Glu Arg Arg Met Asp Lys Ala Gly Gln Tyr Thr Asp Lys Gly 
        675                 680                 685             


Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Asp Ile Pro Met Arg Tyr 
    690                 695                 700                 


Ser Cys Gln Arg Arg Ala Arg Leu Ile Thr Gln Gly Glu Asn Cys Ile 
705                 710                 715                 720 


Lys Ala Phe Ile Asp Cys Cys Asn His Ile Thr Lys Leu Arg Glu Gln 
                725                 730                 735     


His Arg Arg Asp His Val Leu Gly Leu Ala Arg Ser Glu Leu Glu Glu 
            740                 745                 750         


Asp Ile Ile Pro Glu Glu Asp Ile Ile Ser Arg Ser His Phe Pro Gln 
        755                 760                 765             


Ser Trp Leu Trp Thr Ile Glu Glu Leu Lys Glu Pro Glu Lys Asn Gly 
    770                 775                 780                 


Ile Ser Thr Lys Val Met Asn Ile Phe Leu Lys Asp Ser Ile Thr Thr 
785                 790                 795                 800 


Trp Glu Ile Leu Ala Val Ser Leu Ser Asp Lys Lys Gly Ile Cys Val 
                805                 810                 815     


Ala Asp Pro Tyr Glu Ile Arg Val Met Gln Asp Phe Phe Ile Asp Leu 
            820                 825                 830         


Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg Ala 
        835                 840                 845             


Val Leu Phe Asn Tyr Arg Glu Gln Glu Glu Leu Lys Val Arg Val Glu 
    850                 855                 860                 


Leu Leu His Asn Pro Ala Phe Cys Ser Met Ala Thr Ala Lys Asn Arg 
865                 870                 875                 880 


Tyr Phe Gln Thr Ile Lys Ile Pro Pro Lys Ser Ser Val Ala Val Pro 
                885                 890                 895     


Tyr Val Ile Val Pro Leu Lys Ile Gly Gln Gln Glu Val Glu Val Lys 
            900                 905                 910         


Ala Ala Val Phe Asn His Phe Ile Ser Asp Gly Val Lys Lys Thr Leu 
        915                 920                 925             


Lys Val Val Pro Glu Gly Met Arg Ile Asn Lys Thr Val Ala Ile His 
    930                 935                 940                 


Thr Leu Asp Pro Glu Lys Leu Gly Gln Gly Gly Val Gln Lys Val Asp 
945                 950                 955                 960 


Val Pro Ala Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Asp Ser Glu 
                965                 970                 975     


Thr Arg Ile Ile Leu Gln Gly Ser Pro Val Val Gln Met Ala Glu Asp 
            980                 985                 990         


Ala Val Asp Gly Glu Arg Leu Lys  His Leu Ile Val Thr  Pro Ala Gly 
        995                 1000                 1005             


Cys Gly  Glu Gln Asn Met Ile  Gly Met Thr Pro Thr  Val Ile Ala 
    1010                 1015                 1020             


Val His  Tyr Leu Asp Gln Thr  Glu Gln Trp Glu Lys  Phe Gly Ile 
    1025                 1030                 1035             


Glu Lys  Arg Gln Glu Ala Leu  Glu Leu Ile Lys Lys  Gly Tyr Thr 
    1040                 1045                 1050             


Gln Gln  Leu Ala Phe Lys Gln  Pro Ser Ser Ala Tyr  Ala Ala Phe 
    1055                 1060                 1065             


Asn Asn  Arg Pro Pro Ser Thr  Trp Leu Thr Ala Tyr  Val Val Lys 
    1070                 1075                 1080             


Val Phe  Ser Leu Ala Ala Asn  Leu Ile Ala Ile Asp  Ser His Val 
    1085                 1090                 1095             


Leu Cys  Gly Ala Val Lys Trp  Leu Ile Leu Glu Lys  Gln Lys Pro 
    1100                 1105                 1110             


Asp Gly  Val Phe Gln Glu Asp  Gly Pro Val Ile His  Gln Glu Met 
    1115                 1120                 1125             


Ile Gly  Gly Phe Arg Asn Ala  Lys Glu Ala Asp Val  Ser Leu Thr 
    1130                 1135                 1140             


Ala Phe  Val Leu Ile Ala Leu  Gln Glu Ala Arg Asp  Ile Cys Glu 
    1145                 1150                 1155             


Gly Gln  Val Asn Ser Leu Pro  Gly Ser Ile Asn Lys  Ala Gly Glu 
    1160                 1165                 1170             


Tyr Ile  Glu Ala Ser Tyr Met  Asn Leu Gln Arg Pro  Tyr Thr Val 
    1175                 1180                 1185             


Ala Ile  Ala Gly Tyr Ala Leu  Ala Leu Met Asn Lys  Leu Glu Glu 
    1190                 1195                 1200             


Pro Tyr  Leu Gly Lys Phe Leu  Asn Thr Ala Lys Asp  Arg Asn Arg 
    1205                 1210                 1215             


Trp Glu  Glu Pro Asp Gln Gln  Leu Tyr Asn Val Glu  Ala Thr Ser 
    1220                 1225                 1230             


Tyr Ala  Leu Leu Ala Leu Leu  Leu Leu Lys Asp Phe  Asp Ser Val 
    1235                 1240                 1245             


Pro Pro  Val Val Arg Trp Leu  Asn Glu Gln Arg Tyr  Tyr Gly Gly 
    1250                 1255                 1260             


Gly Tyr  Gly Ser Thr Gln Ala  Thr Phe Met Val Phe  Gln Ala Leu 
    1265                 1270                 1275             


Ala Gln  Tyr Gln Thr Asp Val  Pro Asp His Lys Asp  Leu Asn Met 
    1280                 1285                 1290             


Asp Val  Ser Phe His Leu Pro  Ser Arg Ser Ser Ala  Thr Thr Phe 
    1295                 1300                 1305             


Arg Leu  Leu Trp Glu Asn Gly  Asn Leu Leu Arg Ser  Glu Glu Thr 
    1310                 1315                 1320             


Lys Gln  Asn Glu Ala Phe Ser  Leu Thr Ala Lys Gly  Lys Gly Arg 
    1325                 1330                 1335             


Gly Thr  Leu Ser Val Val Ala  Val Tyr His Ala Lys  Leu Lys Ser 
    1340                 1345                 1350             


Lys Val  Thr Cys Lys Lys Phe  Asp Leu Arg Val Ser  Ile Arg Pro 
    1355                 1360                 1365             


Ala Pro  Glu Thr Ala Lys Lys  Pro Glu Glu Ala Lys  Asn Thr Met 
    1370                 1375                 1380             


Phe Leu  Glu Ile Cys Thr Lys  Tyr Leu Gly Asp Val  Asp Ala Thr 
    1385                 1390                 1395             


Met Ser  Ile Leu Asp Ile Ser  Met Met Thr Gly Phe  Ala Pro Asp 
    1400                 1405                 1410             


Thr Lys  Asp Leu Glu Leu Leu  Ala Ser Gly Val Asp  Arg Tyr Ile 
    1415                 1420                 1425             


Ser Lys  Tyr Glu Met Asn Lys  Ala Phe Ser Asn Lys  Asn Thr Leu 
    1430                 1435                 1440             


Ile Ile  Tyr Leu Glu Lys Ile  Ser His Thr Glu Glu  Asp Cys Leu 
    1445                 1450                 1455             


Thr Phe  Lys Val His Gln Tyr  Phe Asn Val Gly Leu  Ile Gln Pro 
    1460                 1465                 1470             


Gly Ser  Val Lys Val Tyr Ser  Tyr Tyr Asn Leu Glu  Glu Ser Cys 
    1475                 1480                 1485             


Thr Arg  Phe Tyr His Pro Glu  Lys Asp Asp Gly Met  Leu Ser Lys 
    1490                 1495                 1500             


Leu Cys  His Ser Glu Met Cys  Arg Cys Ala Glu Glu  Asn Cys Phe 
    1505                 1510                 1515             


Met Gln  Gln Ser Gln Glu Lys  Ile Asn Leu Asn Val  Arg Leu Asp 
    1520                 1525                 1530             


Lys Ala  Cys Glu Pro Gly Val  Asp Tyr Val Tyr Lys  Thr Glu Leu 
    1535                 1540                 1545             


Thr Asn  Ile Glu Leu Leu Asp  Asp Phe Asp Glu Tyr  Thr Met Thr 
    1550                 1555                 1560             


Ile Gln  Gln Val Ile Lys Ser  Gly Ser Asp Glu Val  Gln Ala Gly 
    1565                 1570                 1575             


Gln Gln  Arg Lys Phe Ile Ser  His Ile Lys Cys Arg  Asn Ala Leu 
    1580                 1585                 1590             


Lys Leu  Gln Lys Gly Lys Lys  Tyr Leu Met Trp Gly  Leu Ser Ser 
    1595                 1600                 1605             


Asp Leu  Trp Gly Glu Lys Pro  Asn Thr Ser Tyr Ile  Ile Gly Lys 
    1610                 1615                 1620             


Asp Thr  Trp Val Glu His Trp  Pro Glu Ala Glu Glu  Cys Gln Asp 
    1625                 1630                 1635             


Gln Lys  Tyr Gln Lys Gln Cys  Glu Glu Leu Gly Ala  Phe Thr Glu 
    1640                 1645                 1650             


Ser Met  Val Val Tyr Gly Cys  Pro Asn 
    1655                 1660         


<210>  28
<211>  305
<212>  PRT
<213>  Mus musculus

<400>  28

Ala Gln Arg Asn Leu Asn Glu Leu Cys Tyr Asn Glu Gly Asn Asp Asn 
1               5                   10                  15      


Lys Leu Tyr His Val Leu Asn Ser Lys Asn Gly Lys Ile Tyr Asn Arg 
            20                  25                  30          


Asn Thr Val Asn Arg Leu Leu Pro Met Leu Arg Arg Lys Lys Asn Glu 
        35                  40                  45              


Lys Lys Asn Glu Lys Ile Glu Arg Asn Asn Lys Leu Lys Gln Pro Pro 
    50                  55                  60                  


Pro Pro Pro Asn Pro Asn Asp Pro Pro Pro Pro Asn Pro Asn Asp Pro 
65                  70                  75                  80  


Pro Pro Pro Asn Pro Asn Asp Pro Pro Pro Pro Asn Pro Asn Asp Pro 
                85                  90                  95      


Pro Pro Pro Asn Ala Asn Asp Pro Pro Pro Pro Asn Ala Asn Asp Pro 
            100                 105                 110         


Ala Pro Pro Asn Ala Asn Asp Pro Ala Pro Pro Asn Ala Asn Asp Pro 
        115                 120                 125             


Ala Pro Pro Asn Ala Asn Asp Pro Ala Pro Pro Asn Ala Asn Asp Pro 
    130                 135                 140                 


Ala Pro Pro Asn Ala Asn Asp Pro Ala Pro Pro Asn Ala Asn Asp Pro 
145                 150                 155                 160 


Pro Pro Pro Asn Pro Asn Asp Pro Ala Pro Pro Gln Gly Asn Asn Asn 
                165                 170                 175     


Pro Gln Pro Gln Pro Arg Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln 
            180                 185                 190         


Pro Gln Pro Gln Pro Gln Pro Gln Pro Arg Pro Gln Pro Gln Pro Gln 
        195                 200                 205             


Pro Gly Gly Asn Asn Asn Asn Lys Asn Asn Asn Asn Asp Asp Ser Tyr 
    210                 215                 220                 


Ile Pro Ser Ala Glu Lys Ile Leu Glu Phe Val Lys Gln Ile Arg Asp 
225                 230                 235                 240 


Ser Ile Thr Glu Glu Trp Ser Gln Cys Asn Val Thr Cys Gly Ser Gly 
                245                 250                 255     


Ile Arg Val Arg Lys Arg Lys Gly Ser Asn Lys Lys Ala Glu Asp Leu 
            260                 265                 270         


Thr Leu Glu Asp Ile Asp Thr Glu Ile Cys Lys Met Asp Lys Cys Ser 
        275                 280                 285             


Ser Ile Phe Asn Ile Val Ser Asn Ser Leu Gly Phe Val Ile Leu Leu 
    290                 295                 300                 


Val 
305 


<210>  29
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  primer for C-terminal part of CSP of pCI-CSP-3xC3d construct

<400>  29
aatgctctag aacatgtggt tctggtataa gag                                    33


<210>  30
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  primer for C-terminal part of CSP of pCI-CSP-3xC3d construct

<400>  30
aatgcgaatt cttaggatcc acttgaacat ttatccattt tacaaa                      46


<210>  31
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Linker DNA in construct pCSD-linker-p28-linker-p28-linker-p28

<400>  31
aggcggcggt tcaggaggcg gcggtagc                                          28


<210>  32
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Linker AA in construct pAN494 
       (CSP-G4SG4S-p28-G4SG4S-p28-G4SG4S-p28-STOP)

<400>  32

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  33
<211>  1663
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn 
            20                  25                  30          


Ile Leu Arg Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp 
        35                  40                  45              


Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly 
    50                  55                  60                  


Lys Lys Leu Val Leu Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr 
65                  70                  75                  80  


Asn His Met Gly Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe 
                85                  90                  95      


Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe 
            100                 105                 110         


Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 
        115                 120                 125             


Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 
    130                 135                 140                 


Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly 
145                 150                 155                 160 


Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 
                165                 170                 175     


Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 
            180                 185                 190         


Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 
        195                 200                 205             


Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val 
    210                 215                 220                 


Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu 
225                 230                 235                 240 


Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr 
                245                 250                 255     


Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile 
            260                 265                 270         


Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu 
        275                 280                 285             


Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 
    290                 295                 300                 


Lys Val Leu Leu Asp Gly Val Gln Asn Pro Arg Ala Glu Asp Leu Val 
305                 310                 315                 320 


Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser 
                325                 330                 335     


Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 
            340                 345                 350         


Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met 
        355                 360                 365             


Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 
    370                 375                 380                 


Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu 
385                 390                 395                 400 


Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser 
                405                 410                 415     


Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser 
            420                 425                 430         


Glu Ala Glu Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr 
        435                 440                 445             


Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu 
    450                 455                 460                 


Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp 
465                 470                 475                 480 


Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn 
                485                 490                 495     


Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val 
545                 550                 555                 560 


Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val 
                565                 570                 575     


Pro Gly Gln Gln Met Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg 
            580                 585                 590         


Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 
        595                 600                 605             


Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 
    610                 615                 620                 


Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 
625                 630                 635                 640 


Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln 
                645                 650                 655     


Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser 
            660                 665                 670         


Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys 
        675                 680                 685             


Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg 
    690                 695                 700                 


Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys 
705                 710                 715                 720 


Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg 
                725                 730                 735     


Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 
            740                 745                 750         


Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 
        755                 760                 765             


Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn 
    770                 775                 780                 


Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 
785                 790                 795                 800 


Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg 
865                 870                 875                 880 


Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val 
    930                 935                 940                 


Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu 
945                 950                 955                 960 


Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser 
                965                 970                 975     


Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu 
            980                 985                 990         


Asp Ala Val Asp Ala Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ser 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Glu  Thr Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Leu Glu  Lys Arg Gln Gly Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Gln  Gln Leu Ala Phe Arg  Gln Pro Ser Ser Ala  Phe Ala Ala 
    1055                 1060                 1065             


Phe Val  Lys Arg Ala Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Val  Asn Leu Ile Ala Ile  Asp Ser Gln 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Ala Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Leu Arg Asn  Asn Asn Glu Lys Asp  Met Ala Leu 
    1130                 1135                 1140             


Thr Ala  Phe Val Leu Ile Ser  Leu Gln Glu Ala Lys  Asp Ile Cys 
    1145                 1150                 1155             


Glu Glu  Gln Val Asn Ser Leu  Pro Gly Ser Ile Thr  Lys Ala Gly 
    1160                 1165                 1170             


Asp Phe  Leu Glu Ala Asn Tyr  Met Asn Leu Gln Arg  Ser Tyr Thr 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Gln Met Gly  Arg Leu Lys 
    1190                 1195                 1200             


Gly Pro  Leu Leu Asn Lys Phe  Leu Thr Thr Ala Lys  Asp Lys Asn 
    1205                 1210                 1215             


Arg Trp  Glu Asp Pro Gly Lys  Gln Leu Tyr Asn Val  Glu Ala Thr 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Gln Leu Lys Asp  Phe Asp Phe 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Lys Asp  Ala Pro Asp His Gln  Glu Leu Asn 
    1280                 1285                 1290             


Leu Asp  Val Ser Leu Gln Leu  Pro Ser Arg Ser Ser  Lys Ile Thr 
    1295                 1300                 1305             


His Arg  Ile His Trp Glu Ser  Ala Ser Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Thr Lys  Glu Asn Glu Gly Phe  Thr Val Thr Ala Glu  Gly Lys Gly 
    1325                 1330                 1335             


Gln Gly  Thr Leu Ser Val Val  Thr Met Tyr His Ala  Lys Ala Lys 
    1340                 1345                 1350             


Asp Gln  Leu Thr Cys Asn Lys  Phe Asp Leu Lys Val  Thr Ile Lys 
    1355                 1360                 1365             


Pro Ala  Pro Glu Thr Glu Lys  Arg Pro Gln Asp Ala  Lys Asn Thr 
    1370                 1375                 1380             


Met Ile  Leu Glu Ile Cys Thr  Arg Tyr Arg Gly Asp  Gln Asp Ala 
    1385                 1390                 1395             


Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Thr  Asp Asp Leu Lys Gln  Leu Ala Asn Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Leu Asp  Lys Ala Phe Ser Asp  Arg Asn Thr 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Asp Lys  Val Ser His Ser Glu  Asp Asp Cys 
    1445                 1450                 1455             


Leu Ala  Phe Lys Val His Gln  Tyr Phe Asn Val Glu  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ala Val Lys Val Tyr  Ala Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Thr  Arg Phe Tyr His Pro  Glu Lys Glu Asp Gly  Lys Leu Asn 
    1490                 1495                 1500             


Lys Leu  Cys Arg Asp Glu Leu  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Ile  Gln Lys Ser Asp Asp  Lys Val Thr Leu Glu  Glu Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Arg 
    1535                 1540                 1545             


Leu Val  Lys Val Gln Leu Ser  Asn Asp Phe Asp Glu  Tyr Ile Met 
    1550                 1555                 1560             


Ala Ile  Glu Gln Thr Ile Lys  Ser Gly Ser Asp Glu  Val Gln Val 
    1565                 1570                 1575             


Gly Gln  Gln Arg Thr Phe Ile  Ser Pro Ile Lys Cys  Arg Glu Ala 
    1580                 1585                 1590             


Leu Lys  Leu Glu Glu Lys Lys  His Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Phe Trp Gly Glu Lys  Pro Asn Leu Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Glu Asp  Glu Cys Gln 
    1625                 1630                 1635             


Asp Glu  Glu Asn Gln Lys Gln  Cys Gln Asp Leu Gly  Ala Phe Thr 
    1640                 1645                 1650             


Glu Ser  Met Val Val Phe Gly  Cys Pro Asn 
    1655                 1660             


<210>  34
<211>  5091
<212>  DNA
<213>  Homo sapiens

<400>  34
ctgtccctct gaccctgcac tgtcccagca ccatgggacc cacctcaggt cccagcctgc       60

tgctcctgct actaacccac ctccccctgg ctctggggag tcccatgtac tctatcatca      120

cccccaacat cttgcggctg gagagcgagg agaccatggt gctggaggcc cacgacgcgc      180

aaggggatgt tccagtcact gttactgtcc acgacttccc aggcaaaaaa ctagtgctgt      240

ccagtgagaa gactgtgctg acccctgcca ccaaccacat gggcaacgtc accttcacga      300

tcccagccaa cagggagttc aagtcagaaa aggggcgcaa caagttcgtg accgtgcagg      360

ccaccttcgg gacccaagtg gtggagaagg tggtgctggt cagcctgcag agcgggtacc      420

tcttcatcca gacagacaag accatctaca cccctggctc cacagttctc tatcggatct      480

tcaccgtcaa ccacaagctg ctacccgtgg gccggacggt catggtcaac attgagaacc      540

cggaaggcat cccggtcaag caggactcct tgtcttctca gaaccagctt ggcgtcttgc      600

ccttgtcttg ggacattccg gaactcgtca acatgggcca gtggaagatc cgagcctact      660

atgaaaactc accacagcag gtcttctcca ctgagtttga ggtgaaggag tacgtgctgc      720

ccagtttcga ggtcatagtg gagcctacag agaaattcta ctacatctat aacgagaagg      780

gcctggaggt caccatcacc gccaggttcc tctacgggaa gaaagtggag ggaactgcct      840

ttgtcatctt cgggatccag gatggcgaac agaggatttc cctgcctgaa tccctcaagc      900

gcattccgat tgaggatggc tcgggggagg ttgtgctgag ccgaaaggta ctgctggacg      960

gggtgcagaa cccccgagca gaagacctgg tggggaagtc tttgtacgtg tctgccaccg     1020

tcatcttgca ctcaggcagt gacatggtgc aggcagagcg cagcgggatc cccatcgtga     1080

cctctcccta ccagatccac ttcaccaaga cacccaagta cttcaaacca ggaatgccct     1140

ttgacctcat ggtgttcgtg acgaaccctg atggctctcc agcctaccga gtccccgtgg     1200

cagtccaggg cgaggacact gtgcagtctc taacccaggg agatggcgtg gccaaactca     1260

gcatcaacac acaccccagc cagaagccct tgagcatcac ggtgcgcacg aagaagcagg     1320

agctctcgga ggcagagcag gctaccagga ccatgcaggc tctgccctac agcaccgtgg     1380

gcaactccaa caattacctg catctctcag tgctacgtac agagctcaga cccggggaga     1440

ccctcaacgt caacttcctc ctgcgaatgg accgcgccca cgaggccaag atccgctact     1500

acacctacct gatcatgaac aagggcaggc tgttgaaggc gggacgccag gtgcgagagc     1560

ccggccagga cctggtggtg ctgcccctgt ccatcaccac cgacttcatc ccttccttcc     1620

gcctggtggc gtactacacg ctgatcggtg ccagcggcca gagggaggtg gtggccgact     1680

ccgtgtgggt ggacgtcaag gactcctgcg tgggctcgct ggtggtaaaa agcggccagt     1740

cagaagaccg gcagcctgta cctgggcagc agatgaccct gaagatagag ggtgaccacg     1800

gggcccgggt ggtactggtg gccgtggaca agggcgtgtt cgtgctgaat aagaagaaca     1860

aactgacaca gagtaagatc tgggacgtgg tggagaaggc agacatcggc tgcaccccgg     1920

gcagtgggaa ggattacgcc ggtgtcttct ccgacgcagg gctgaccttc acgagcagca     1980

gtggccagca gaccgcccag agggcagaac ttcagtgccc gcagccagcc gcccgccgac     2040

gccgttccgt gcagctcacg gagaagcgaa tggacaaagt cggcaagtac cccaaggagc     2100

tgcgcaagtg ctgcgaggac ggcatgcggg agaaccccat gaggttctcg tgccagcgcc     2160

ggacccgttt catctccctg ggcgaggcgt gcaagaaggt cttcctggac tgctgcaact     2220

acatcacaga gctgcggcgg cagcacgcgc gggccagcca cctgggcctg gccaggagta     2280

acctggatga ggacatcatt gcagaagaga acatcgtttc ccgaagtgag ttcccagaga     2340

gctggctgtg gaacgttgag gacttgaaag agccaccgaa aaatggaatc tctacgaagc     2400

tcatgaatat atttttgaaa gactccatca ccacgtggga gattctggct gtcagcatgt     2460

cggacaagaa agggatctgt gtggcagacc ccttcgaggt cacagtaatg caggacttct     2520

tcatcgacct gcggctaccc tactctgttg ttcgaaacga gcaggtggaa atccgagccg     2580

ttctctacaa ttaccggcag aaccaagagc tcaaggtgag ggtggaacta ctccacaatc     2640

cagccttctg cagcctggcc accaccaaga ggcgtcacca gcagaccgta accatccccc     2700

ccaagtcctc gttgtccgtt ccatatgtca tcgtgccgct aaagaccggc ctgcaggaag     2760

tggaagtcaa ggctgccgtc taccatcatt tcatcagtga cggtgtcagg aagtccctga     2820

aggtcgtgcc ggaaggaatc agaatgaaca aaactgtggc tgttcgcacc ctggatccag     2880

aacgcctggg ccgtgaagga gtgcagaaag aggacatccc acctgcagac ctcagtgacc     2940

aagtcccgga caccgagtct gagaccagaa ttctcctgca agggacccca gtggcccaga     3000

tgacagagga tgccgtcgac gcggaacggc tgaagcacct cattgtgacc ccctcgggct     3060

gcggggaaca gaacatgatc ggcatgacgc ccacggtcat cgctgtgcat tacctggatg     3120

aaacggagca gtgggagaag ttcggcctag agaagcggca gggggccttg gagctcatca     3180

agaaggggta cacccagcag ctggccttca gacaacccag ctctgccttt gcggccttcg     3240

tgaaacgggc acccagcacc tggctgaccg cctacgtggt caaggtcttc tctctggctg     3300

tcaacctcat cgccatcgac tcccaagtcc tctgcggggc tgttaaatgg ctgatcctgg     3360

agaagcagaa gcccgacggg gtcttccagg aggatgcgcc cgtgatacac caagaaatga     3420

ttggtggatt acggaacaac aacgagaaag acatggccct cacggccttt gttctcatct     3480

cgctgcagga ggctaaagat atttgcgagg agcaggtcaa cagcctgcca ggcagcatca     3540

ctaaagcagg agacttcctt gaagccaact acatgaacct acagagatcc tacactgtgg     3600

ccattgctgg ctatgctctg gcccagatgg gcaggctgaa ggggcctctt cttaacaaat     3660

ttctgaccac agccaaagat aagaaccgct gggaggaccc tggtaagcag ctctacaacg     3720

tggaggccac atcctatgcc ctcttggccc tactgcagct aaaagacttt gactttgtgc     3780

ctcccgtcgt gcgttggctc aatgaacaga gatactacgg tggtggctat ggctctaccc     3840

aggccacctt catggtgttc caagccttgg ctcaatacca aaaggacgcc cctgaccacc     3900

aggaactgaa ccttgatgtg tccctccaac tgcccagccg cagctccaag atcacccacc     3960

gtatccactg ggaatctgcc agcctcctgc gatcagaaga gaccaaggaa aatgagggtt     4020

tcacagtcac agctgaagga aaaggccaag gcaccttgtc ggtggtgaca atgtaccatg     4080

ctaaggccaa agatcaactc acctgtaata aattcgacct caaggtcacc ataaaaccag     4140

caccggaaac agaaaagagg cctcaggatg ccaagaacac tatgatcctt gagatctgta     4200

ccaggtaccg gggagaccag gatgccacta tgtctatatt ggacatatcc atgatgactg     4260

gctttgctcc agacacagat gacctgaagc agctggccaa tggtgttgac agatacatct     4320

ccaagtatga gctggacaaa gccttctccg ataggaacac cctcatcatc tacctggaca     4380

aggtctcaca ctctgaggat gactgtctag ctttcaaagt tcaccaatac tttaatgtag     4440

agcttatcca gcctggagca gtcaaggtct acgcctatta caacctggag gaaagctgta     4500

cccggttcta ccatccggaa aaggaggatg gaaagctgaa caagctctgc cgtgatgaac     4560

tgtgccgctg tgctgaggag aattgcttca tacaaaagtc ggatgacaag gtcaccctgg     4620

aagaacggct ggacaaggcc tgtgagccag gagtggacta tgtgtacaag acccgactgg     4680

tcaaggttca gctgtccaat gactttgacg agtacatcat ggccattgag cagaccatca     4740

agtcaggctc ggatgaggtg caggttggac agcagcgcac gttcatcagc cccatcaagt     4800

gcagagaagc cctgaagctg gaggagaaga aacactacct catgtggggt ctctcctccg     4860

atttctgggg agagaagccc aacctcagct acatcatcgg gaaggacact tgggtggagc     4920

actggcccga ggaggacgaa tgccaagacg aagagaacca gaaacaatgc caggacctcg     4980

gcgccttcac cgagagcatg gttgtctttg ggtgccccaa ctgaccacac ccccattccc     5040

ccactccaga taaagcttca gttataaaaa aaaaaaaaaa aaaaaaaaaa a              5091


<210>  35
<211>  291
<212>  PRT
<213>  Plasmodium berghei

<400>  35

Ile Gln Ala Gln Arg Asn Leu Asn Glu Leu Cys Tyr Asn Glu Gly Asn 
1               5                   10                  15      


Asp Asn Lys Leu Tyr His Val Leu Asn Ser Lys Asn Gly Lys Ile Tyr 
            20                  25                  30          


Asn Arg Asn Thr Val Asn Arg Leu Leu Pro Met Leu Arg Arg Lys Lys 
        35                  40                  45              


Asn Glu Lys Lys Asn Glu Lys Ile Glu Arg Asn Asn Lys Leu Lys Gln 
    50                  55                  60                  


Pro Pro Pro Pro Pro Asn Pro Asn Asp Pro Pro Pro Pro Asn Pro Asn 
65                  70                  75                  80  


Asp Pro Pro Pro Pro Asn Pro Asn Asp Pro Pro Pro Pro Asn Pro Asn 
                85                  90                  95      


Asp Pro Pro Pro Pro Asn Ala Asn Asp Pro Pro Pro Pro Asn Ala Asn 
            100                 105                 110         


Asp Pro Ala Pro Pro Asn Ala Asn Asp Pro Ala Pro Pro Asn Ala Asn 
        115                 120                 125             


Asp Pro Ala Pro Pro Asn Ala Asn Asp Pro Ala Pro Pro Asn Ala Asn 
    130                 135                 140                 


Asp Pro Ala Pro Pro Asn Ala Asn Asp Pro Ala Pro Pro Asn Ala Asn 
145                 150                 155                 160 


Asp Pro Pro Pro Pro Asn Pro Asn Asp Pro Ala Pro Pro Gln Gly Asn 
                165                 170                 175     


Asn Asn Pro Gln Pro Gln Pro Arg Pro Gln Pro Gln Pro Gln Pro Gln 
            180                 185                 190         


Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Arg Pro Gln Pro Gln 
        195                 200                 205             


Pro Gln Pro Gly Gly Asn Asn Asn Asn Lys Asn Asn Asn Asn Asp Asp 
    210                 215                 220                 


Ser Tyr Ile Pro Ser Ala Glu Lys Ile Leu Glu Phe Val Lys Gln Ile 
225                 230                 235                 240 


Arg Asp Ser Ile Thr Glu Glu Trp Ser Gln Cys Asn Val Thr Cys Gly 
                245                 250                 255     


Ser Gly Ile Arg Val Arg Lys Arg Lys Gly Ser Asn Lys Lys Ala Glu 
            260                 265                 270         


Asp Leu Thr Leu Glu Asp Ile Asp Thr Glu Ile Cys Lys Met Asp Lys 
        275                 280                 285             


Cys Ser Ser 
    290     


<210>  36
<211>  993
<212>  DNA
<213>  Plasmodium berghei

<400>  36
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt       60

tcggctagcg gatccgatgg acaaaataaa agcatccaag cccaaaggaa cttaaacgag      120

ctatgttaca atgaaggaaa tgataataaa ttgtatcacg tgcttaactc taagaatgga      180

aaaatataca atcgaaatac agtcaacaga ttacttgccg atgctcccga aggaaaaaaa      240

aatgagaaaa aaaacgaaaa aatagagcgt aataataaat tgaaacaacc accaccacca      300

ccaaacccaa atgacccacc accaccaaac ccaaatgacc caccaccacc aaacccaaat      360

gacccaccac caccaaaccc aaatgaccca gcaccaccaa acgcaaatga cccagcacca      420

ccaaacgcaa atgacccagc accaccaaac gcaaatgacc cagcaccacc aaacgcaaat      480

gacccagcac caccaaacgc aaatgaccca gcaccaccaa acgcaaatga cccagcacca      540

ccaaacgcaa atgacccagc accaccaaac gcaaatgacc cagcaccacc aaacgcaaat      600

gacccaccac caccaaaccc aaatgaccca gcaccaccac aaggaaataa caatccacaa      660

ccacagccac ggccgcagcc acaaccacag ccacagccac aaccacagcc acagccacaa      720

ccacagccac gaccacagcc acaaccacag ccaggtggta ataacaataa caaaaataat      780

aataatgacg attcttatat cccaagcgcg gaaaaaatac tagaatttgt taaacagatc      840

agggatagta tcacagagga atggtctcaa tgtaacgtaa catgtggttc tggtataaga      900

gttagaaaac gaaaaggttc aaataagaaa gcagaagatt tgaccttaga agatattgat      960

actgaaattt gtaaaatgga taaatgttca agt                                   993


