                         SEQUENCE LISTING

<110>  CureDM, Inc.
       Levetan, Claresa S.
 
<120>  COMPOSITIONS AND METHODS OF USING THE HUMAN PROISLET PEPTIDE 
       RECEPTOR

<130>  132163.00602

<150>  60/979,569
<151>  2007-10-12

<150>  61/031,451
<151>  2008-02-26

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Mesocricetus auratus


<220>
<221>  INGAP
<222>  (1)..(15)

<400>  1

Ile Gly Leu His Asp Pro Ser His Gly Thr Leu Pro Asn Gly Ser 
1               5                   10                  15  


<210>  2
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP3
<222>  (1)..(15)

<400>  2

Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Glu 
1               5                   10                  15  


<210>  3
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP1
<222>  (1)..(15)

<400>  3

Trp Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly 
1               5                   10                  15  


<210>  4
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP2
<222>  (1)..(14)

<400>  4

Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly 
1               5                   10                  


<210>  5
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP3B
<222>  (1)..(15)

<220>
<221>  acylation
<222>  (1)..(1)

<220>
<221>  amidation
<222>  (15)..(15)

<400>  5

Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Glu 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP1B
<222>  (1)..(15)

<220>
<221>  acylation
<222>  (1)..(1)

<220>
<221>  amidation
<222>  (15)..(15)

<400>  6

Trp Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly 
1               5                   10                  15  


<210>  7
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP2B
<222>  (1)..(14)

<220>
<221>  acylation
<222>  (1)..(1)

<220>
<221>  amidation
<222>  (14)..(14)

<400>  7

Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly 
1               5                   10                  


<210>  8
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP3Cys
<222>  (1)..(16)

<400>  8

Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Glu Cys 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP1Cys
<222>  (1)..(16)

<400>  9

Thr Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Cys 
1               5                   10                  15      


<210>  10
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP2Cys
<222>  (1)..(15)

<400>  10

Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Cys 
1               5                   10                  15  


<210>  11
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP3CysDimer
<222>  (1)..(30)

<400>  11

Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Cys Cys 
1               5                   10                  15      


Gly Asn Pro Glu Thr Gly Gln Thr Pro Asp His Leu Gly Ile 
            20                  25                  30  


<210>  12
<211>  34
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP1CysDimer
<222>  (1)..(34)

<400>  12

Trp Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Glu 
1               5                   10                  15      


Cys Cys Glu Gly Asn Pro Glu Thr Gly Gln Thr Pro Asp His Leu Gly 
            20                  25                  30          


Ile Trp 
        


<210>  13
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP2CysDimer
<222>  (1)..(30)

<400>  13

Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Cys Cys 
1               5                   10                  15      


Gly Asn Pro Glu Thr Gly Gln Thr Pro Asp His Leu Gly Ile 
            20                  25                  30  


<210>  14
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP3CysB
<222>  (1)..(16)

<220>
<221>  acylation
<222>  (1)..(1)

<220>
<221>  amidation
<222>  (16)..(16)

<400>  14

Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Glu Cys 
1               5                   10                  15      


<210>  15
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP1CysB
<222>  (1)..(16)

<220>
<221>  acylation
<222>  (1)..(1)

<220>
<221>  amidation
<222>  (16)..(16)

<400>  15

Trp Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Cys 
1               5                   10                  15      


<210>  16
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP2CysB
<222>  (1)..(15)

<220>
<221>  acylation
<222>  (1)..(1)

<220>
<221>  amidation
<222>  (15)..(15)

<400>  16

Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Cys 
1               5                   10                  15  


<210>  17
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP3CysBlockedDimer
<222>  (1)..(16)

<220>
<221>  acylation
<222>  (1)..(1)

<220>
<221>  amidation
<222>  (16)..(16)

<400>  17

Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Glu Cys 
1               5                   10                  15      


<210>  18
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP1CysBlockedDimer
<222>  (1)..(16)

<220>
<221>  acylation
<222>  (1)..(1)

<220>
<221>  amidation
<222>  (16)..(16)

<400>  18

Trp Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Cys 
1               5                   10                  15      


<210>  19
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP2CysBlockedDimer
<222>  (1)..(15)

<220>
<221>  acylation
<222>  (1)..(1)

<220>
<221>  amidation
<222>  (15)..(15)

<400>  19

Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Cys 
1               5                   10                  15  


<210>  20
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP3CysPEG
<222>  (1)..(16)

<220>
<221>  pegylation
<222>  (16)..(16)

<400>  20

Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Glu Cys 
1               5                   10                  15      


<210>  21
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP1CysPEG
<222>  (1)..(16)

<220>
<221>  pegylation
<222>  (16)..(16)

<400>  21

Trp Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Cys 
1               5                   10                  15      


<210>  22
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP2CysPEG
<222>  (1)..(15)

<220>
<221>  pegylation
<222>  (15)..(15)

<400>  22

Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Cys 
1               5                   10                  15  


<210>  23
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP3CysBlockedPEG
<222>  (1)..(16)

<220>
<221>  acylation
<222>  (1)..(1)

<220>
<221>  pegylation
<222>  (16)..(16)

<220>
<221>  amidation
<222>  (16)..(16)

<400>  23

Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Glu Cys 
1               5                   10                  15      


<210>  24
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP1CysBlockedPEG
<222>  (1)..(16)

<220>
<221>  acylation
<222>  (1)..(1)

<220>
<221>  pegylation
<222>  (16)..(16)

<220>
<221>  amidation
<222>  (16)..(16)

<400>  24

Trp Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Cys 
1               5                   10                  15      


<210>  25
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP2CysBlockedPEG
<222>  (1)..(15)

<220>
<221>  acylation
<222>  (1)..(1)

<220>
<221>  pegylation
<222>  (15)..(15)

<220>
<221>  amidation
<222>  (15)..(15)

<400>  25

Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Cys 
1               5                   10                  15  


<210>  26
<211>  175
<212>  PRT
<213>  Homo sapiens


<220>
<221>  REG3A
<222>  (1)..(175)

<400>  26

Met Leu Pro Pro Met Ala Leu Pro Ser Val Ser Trp Met Leu Leu Ser 
1               5                   10                  15      


Cys Leu Met Leu Leu Ser Gln Val Gln Gly Glu Glu Pro Gln Arg Glu 
            20                  25                  30          


Leu Pro Ser Ala Arg Ile Arg Cys Pro Lys Gly Ser Lys Ala Tyr Gly 
        35                  40                  45              


Ser His Cys Tyr Ala Leu Phe Leu Ser Pro Lys Ser Trp Thr Asp Ala 
    50                  55                  60                  


Asp Leu Ala Cys Gln Lys Arg Pro Ser Gly Asn Leu Val Ser Val Leu 
65                  70                  75                  80  


Ser Gly Ala Glu Gly Ser Phe Val Ser Ser Leu Val Lys Ser Ile Gly 
                85                  90                  95      


Asn Ser Tyr Ser Tyr Val Trp Ile Gly Leu His Asp Pro Thr Gln Gly 
            100                 105                 110         


Thr Glu Pro Asn Gly Glu Gly Trp Glu Trp Ser Ser Ser Asp Val Met 
        115                 120                 125             


Asn Tyr Phe Ala Trp Glu Arg Asn Pro Ser Thr Ile Ser Ser Pro Gly 
    130                 135                 140                 


His Cys Ala Ser Leu Ser Arg Ser Thr Ala Phe Leu Arg Trp Lys Asp 
145                 150                 155                 160 


Tyr Asn Cys Asn Val Arg Leu Pro Tyr Val Cys Lys Phe Thr Asp 
                165                 170                 175 


<210>  27
<211>  166
<212>  PRT
<213>  Homo sapiens


<220>
<221>  REG1A
<222>  (1)..(166)

<400>  27

Met Ala Gln Thr Ser Ser Tyr Phe Met Leu Ile Ser Cys Leu Met Phe 
1               5                   10                  15      


Leu Ser Gln Ser Gln Gly Gln Glu Ala Gln Thr Glu Leu Pro Gln Ala 
            20                  25                  30          


Arg Ile Ser Cys Pro Glu Gly Thr Asn Ala Tyr Arg Ser Tyr Cys Tyr 
        35                  40                  45              


Tyr Phe Asn Glu Asp Arg Glu Thr Trp Val Asp Ala Asp Leu Tyr Cys 
    50                  55                  60                  


Gln Asn Met Asn Ser Gly Asn Leu Val Ser Val Leu Thr Gln Ala Glu 
65                  70                  75                  80  


Gly Ala Phe Val Ala Ser Leu Ile Lys Glu Ser Gly Thr Asp Asp Phe 
                85                  90                  95      


Asn Val Trp Ile Gly Leu His Asp Pro Lys Lys Asn Arg Arg Trp His 
            100                 105                 110         


Trp Ser Ser Gly Ser Leu Val Ser Tyr Lys Ser Trp Gly Ile Gly Ala 
        115                 120                 125             


Pro Ser Ser Val Asn Pro Gly Tyr Cys Val Ser Leu Thr Ser Ser Thr 
    130                 135                 140                 


Gly Phe Gln Lys Trp Lys Asp Val Pro Cys Glu Asp Lys Phe Ser Phe 
145                 150                 155                 160 


Val Cys Lys Phe Lys Asn 
                165     


<210>  28
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HIP
<222>  (1)..(14)

<400>  28

Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly 
1               5                   10                  


<210>  29
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  29

Trp Ile Gly Leu His Asp Pro Thr Gln Gly Thr Glu Pro Asn Gly Glu 
1               5                   10                  15      


<210>  30
<211>  16
<212>  PRT
<213>  Pan troglodytes

<400>  30

Trp Ile Gly Leu His Asp Pro Thr Gln Gly Ser Glu Pro Asp Gly Gly 
1               5                   10                  15      


<210>  31
<211>  16
<212>  PRT
<213>  Mesocricetus auratus

<400>  31

Trp Ile Gly Leu His Asp Pro Ser His Gly Thr Leu Pro Asn Gly Ser 
1               5                   10                  15      


<210>  32
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  32

Trp Ile Gly Leu His Asp Pro Thr Met Gly Gln Gln Pro Asn Gly Gly 
1               5                   10                  15      


<210>  33
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  33

Trp Ile Trp Leu His Asp Pro Thr Met Gly Gln Gln Pro Asn Gly Gly 
1               5                   10                  15      


<210>  34
<211>  16
<212>  PRT
<213>  Bos taurus

<400>  34

Trp Ile Gly Leu His Asp Pro Thr Glu Gly Ser Glu Pro Asp Ala Gly 
1               5                   10                  15      


<210>  35
<211>  16
<212>  PRT
<213>  Canis familiaris

<400>  35

Trp Met Gly Leu His Asp Pro Thr Glu Gly Tyr Glu Pro Asn Ala Asp 
1               5                   10                  15      


<210>  36
<211>  16
<212>  PRT
<213>  Ovis aries

<400>  36

Trp Ile Gly Leu His Asp Pro Thr Glu Gly Ser Glu Pro Asn Ala Gly 
1               5                   10                  15      


<210>  37
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Thr Gly Tyr Thr Met Leu Arg Asn Gly Gly Ala Gly Asn Gly Gly 
1               5                   10                  15      


Gln Thr Cys Met Leu Arg Trp Ser Asn Arg Ile Arg Leu Thr Trp Leu 
            20                  25                  30          


Ser Phe Thr Leu Phe Val Ile Leu Val Phe Phe Pro Leu Ile Ala His 
        35                  40                  45              


Tyr Tyr Leu Thr Thr Leu Asp Glu Ala Asp Glu Ala Gly Lys Arg Ile 
    50                  55                  60                  


Phe Gly Pro Arg Val Gly Asn Glu Leu Cys Glu Val Lys His Val Leu 
65                  70                  75                  80  


Asp Leu Cys Arg Ile Arg Glu Ser Val Ser Glu Glu Leu Leu Gln Leu 
                85                  90                  95      


Glu Ala Lys Arg Gln Glu Leu Asn Ser Glu Ile Ala Lys Leu Asn Leu 
            100                 105                 110         


Lys Ile Glu Ala Cys Lys Lys Ser Ile Glu Asn Ala Lys Gln Asp Leu 
        115                 120                 125             


Leu Gln Leu Lys Asn Val Ile Ser Gln Thr Glu His Ser Tyr Lys Glu 
    130                 135                 140                 


Leu Met Ala Gln Asn Gln Pro Lys Leu Ser Leu Pro Ile Arg Leu Leu 
145                 150                 155                 160 


Pro Glu Lys Asp Asp Ala Gly Leu Pro Pro Pro Lys Ala Thr Arg Gly 
                165                 170                 175     


Cys Arg Leu His Asn Cys Phe Asp Tyr Ser Arg Cys Pro Leu Thr Ser 
            180                 185                 190         


Gly Phe Pro Val Tyr Val Tyr Asp Ser Asp Gln Phe Val Phe Gly Ser 
        195                 200                 205             


Tyr Leu Asp Pro Leu Val Lys Gln Ala Phe Gln Ala Thr Ala Arg Ala 
    210                 215                 220                 


Asn Val Tyr Val Thr Glu Asn Ala Asp Ile Ala Cys Leu Tyr Val Ile 
225                 230                 235                 240 


Leu Val Gly Glu Met Gln Glu Pro Val Val Leu Arg Pro Ala Glu Leu 
                245                 250                 255     


Glu Lys Gln Leu Tyr Ser Leu Pro His Trp Arg Thr Asp Gly His Asn 
            260                 265                 270         


His Val Ile Ile Asn Leu Ser Arg Lys Ser Asp Thr Gln Asn Leu Leu 
        275                 280                 285             


Tyr Asn Val Ser Thr Gly Arg Ala Met Val Ala Gln Ser Thr Phe Tyr 
    290                 295                 300                 


Thr Val Gln Tyr Arg Pro Gly Phe Asp Leu Val Val Ser Pro Leu Val 
305                 310                 315                 320 


His Ala Met Ser Glu Pro Asn Phe Met Glu Ile Pro Pro Gln Val Pro 
                325                 330                 335     


Val Lys Arg Lys Tyr Leu Phe Thr Phe Gln Gly Glu Lys Ile Glu Ser 
            340                 345                 350         


Leu Arg Ser Ser Leu Gln Glu Ala Arg Ser Phe Glu Glu Glu Met Glu 
        355                 360                 365             


Gly Asp Pro Pro Ala Asp Tyr Asp Asp Arg Ile Ile Ala Thr Leu Lys 
    370                 375                 380                 


Ala Val Gln Asp Ser Lys Leu Asp Gln Val Leu Val Glu Phe Thr Cys 
385                 390                 395                 400 


Lys Asn Gln Pro Lys Pro Ser Leu Pro Thr Glu Trp Ala Leu Cys Gly 
                405                 410                 415     


Glu Arg Glu Asp Arg Leu Glu Leu Leu Lys Leu Ser Thr Phe Ala Leu 
            420                 425                 430         


Ile Ile Thr Pro Gly Asp Pro Arg Leu Val Ile Ser Ser Gly Cys Ala 
        435                 440                 445             


Thr Arg Leu Phe Glu Ala Leu Glu Val Gly Ala Val Pro Val Val Leu 
    450                 455                 460                 


Gly Glu Gln Val Gln Leu Pro Tyr Gln Asp Met Leu Gln Trp Asn Glu 
465                 470                 475                 480 


Ala Ala Leu Val Val Pro Lys Pro Arg Val Thr Glu Val His Phe Leu 
                485                 490                 495     


Leu Arg Ser Leu Ser Asp Ser Asp Leu Leu Ala Met Arg Arg Gln Gly 
            500                 505                 510         


Arg Phe Leu Trp Glu Thr Tyr Phe Ser Thr Ala Asp Ser Ile Phe Asn 
        515                 520                 525             


Thr Val Leu Ala Met Ile Arg Thr Arg Ile Gln Ile Pro Ala Ala Pro 
    530                 535                 540                 


Ile Arg Glu Glu Ala Ala Ala Glu Ile Pro His Arg Ser Gly Lys Ala 
545                 550                 555                 560 


Ala Gly Thr Asp Pro Asn Met Ala Asp Asn Gly Asp Leu Asp Leu Gly 
                565                 570                 575     


Pro Val Glu Thr Glu Pro Pro Tyr Ala Ser Pro Arg Tyr Leu Arg Asn 
            580                 585                 590         


Phe Thr Leu Thr Val Thr Asp Phe Tyr Arg Ser Trp Asn Cys Ala Pro 
        595                 600                 605             


Gly Pro Phe His Leu Phe Pro His Thr Pro Phe Asp Pro Val Leu Pro 
    610                 615                 620                 


Ser Glu Ala Lys Phe Leu Gly Ser Gly Thr Gly Phe Arg Pro Ile Gly 
625                 630                 635                 640 


Gly Gly Ala Gly Gly Ser Gly Lys Glu Phe Gln Ala Ala Leu Gly Gly 
                645                 650                 655     


Asn Val Pro Arg Glu Gln Phe Thr Val Val Met Leu Thr Tyr Glu Arg 
            660                 665                 670         


Glu Glu Val Leu Met Asn Ser Leu Glu Arg Leu Asn Gly Leu Pro Tyr 
        675                 680                 685             


Leu Asn Lys Val Val Val Val Trp Asn Ser Pro Lys Leu Pro Ser Glu 
    690                 695                 700                 


Asp Leu Leu Trp Pro Asp Ile Gly Val Pro Ile Met Val Val Arg Thr 
705                 710                 715                 720 


Glu Lys Asn Ser Leu Asn Asn Arg Phe Leu Pro Trp Asn Glu Ile Glu 
                725                 730                 735     


Thr Glu Ala Ile Leu Ser Ile Asp Asp Asp Ala His Leu Arg His Asp 
            740                 745                 750         


Glu Ile Met Phe Gly Phe Arg Val Trp Arg Glu Ala Arg Asp Arg Ile 
        755                 760                 765             


Val Gly Phe Pro Gly Arg Tyr His Ala Trp Asp Ile Pro His Gln Ser 
    770                 775                 780                 


Trp Leu Tyr Asn Ser Asn Tyr Ser Cys Glu Leu Ser Met Val Leu Thr 
785                 790                 795                 800 


Gly Ala Ala Phe Phe His Lys Tyr Tyr Ala Tyr Leu Tyr Ser Tyr Val 
                805                 810                 815     


Met Pro Gln Ala Ile Arg Asp Met Val Asp Glu Tyr Ile Asn Cys Glu 
            820                 825                 830         


Asp Ile Ala Met Asn Phe Leu Val Ser His Ile Thr Arg Lys Pro Pro 
        835                 840                 845             


Ile Lys Val Thr Ser Arg Trp Thr Phe Arg Cys Pro Gly Cys Pro Gln 
    850                 855                 860                 


Ala Leu Ser His Asp Asp Ser His Phe His Glu Arg His Lys Cys Ile 
865                 870                 875                 880 


Asn Phe Phe Val Lys Val Tyr Gly Tyr Met Pro Leu Leu Tyr Thr Gln 
                885                 890                 895     


Phe Arg Val Asp Ser Val Leu Phe Lys Thr Arg Leu Pro His Asp Lys 
            900                 905                 910         


Thr Lys Cys Phe Lys Phe Ile 
        915                 


