                         SEQUENCE LISTING

<110>  Andersen, Philip
       Beall, Melissa
       Buch, Jesse
       Huth, Stacey
       Krah, Regis
       Hsiao, Ku-chuan
       O'Brien-Graff, Barbara
       Strong-Townsend, Marilyn
 
<120>  Feline Pancreatic Lipase

<130>  07-230-US

<150>  60/980,029
<151>  2007-10-15

<160>  16    

<170>  PatentIn version 3.4

<210>  1
<211>  15
<212>  PRT
<213>  Felis sp.


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is unknown amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is unknown amino acid residue

<400>  1

Lys Glu Ile Xaa Phe Pro Arg Leu Gly Xaa Phe Ser Asp Asp Ala 
1               5                   10                  15  


<210>  2
<211>  1398
<212>  DNA
<213>  Felis sp.


<220>
<221>  CDS
<222>  (1)..(1398)

<400>  2
atg ctg cta atc tgg aca cta tcg ctg ctg ctg gga gca gta gta gga       48
Met Leu Leu Ile Trp Thr Leu Ser Leu Leu Leu Gly Ala Val Val Gly         
1               5                   10                  15              

aaa gaa atc tgc ttc cca aga ctt ggc tgc ttt agc gat gat gcc cca       96
Lys Glu Ile Cys Phe Pro Arg Leu Gly Cys Phe Ser Asp Asp Ala Pro         
            20                  25                  30                  

tgg gca gga att gcg caa aga ccc ctc aaa ata ttg ccc tgg cct cca      144
Trp Ala Gly Ile Ala Gln Arg Pro Leu Lys Ile Leu Pro Trp Pro Pro         
        35                  40                  45                      

aaa gat gtc aat acc cgc ttc ctc ctg tac act aac gag aac ccg aat      192
Lys Asp Val Asn Thr Arg Phe Leu Leu Tyr Thr Asn Glu Asn Pro Asn         
    50                  55                  60                          

aac ttt gaa gaa att att gca gat gaa tca act atc atg agc tct aat      240
Asn Phe Glu Glu Ile Ile Ala Asp Glu Ser Thr Ile Met Ser Ser Asn         
65                  70                  75                  80          

ttc aac aca gat aga aaa acc cgc ttc att att cat gga ttc ata gac      288
Phe Asn Thr Asp Arg Lys Thr Arg Phe Ile Ile His Gly Phe Ile Asp         
                85                  90                  95              

aag gga gaa gaa aac tgg ctg tcc aaa ata tgc aag aac ttg ttt aca      336
Lys Gly Glu Glu Asn Trp Leu Ser Lys Ile Cys Lys Asn Leu Phe Thr         
            100                 105                 110                 

gtg gaa agt gtg aac tgc atc tgc gtg gac tgg aaa agt ggc tcc aaa      384
Val Glu Ser Val Asn Cys Ile Cys Val Asp Trp Lys Ser Gly Ser Lys         
        115                 120                 125                     

acc ggt tac act cag gcc tca cag aac atc cgg att gtg ggg gca gaa      432
Thr Gly Tyr Thr Gln Ala Ser Gln Asn Ile Arg Ile Val Gly Ala Glu         
    130                 135                 140                         

gtg gca tat ttt gtt gaa gtt ctt cag tca gca ttt ggg tac tca cct      480
Val Ala Tyr Phe Val Glu Val Leu Gln Ser Ala Phe Gly Tyr Ser Pro         
145                 150                 155                 160         

tcc aac gtc cac atc att ggc cac agt ctg ggt gcc cac gca gct gga      528
Ser Asn Val His Ile Ile Gly His Ser Leu Gly Ala His Ala Ala Gly         
                165                 170                 175             

gag gca gga agg agg atc aat ggg acg gct ggg cga atc aca ggg ttg      576
Glu Ala Gly Arg Arg Ile Asn Gly Thr Ala Gly Arg Ile Thr Gly Leu         
            180                 185                 190                 

gat cca gct gaa cct tgc ttt gag ggc aca cct gac tta gtc cga ttg      624
Asp Pro Ala Glu Pro Cys Phe Glu Gly Thr Pro Asp Leu Val Arg Leu         
        195                 200                 205                     

gac ccc agc gat gcc ctg ttt gtg gat gta att cac aca gac gct gcc      672
Asp Pro Ser Asp Ala Leu Phe Val Asp Val Ile His Thr Asp Ala Ala         
    210                 215                 220                         

cct ata atc cct aac atg ggg ttt gga atg agc caa acc gta ggc cat      720
Pro Ile Ile Pro Asn Met Gly Phe Gly Met Ser Gln Thr Val Gly His         
225                 230                 235                 240         

cta gat ttc ttt cca aat gga gga aaa gaa atg ccc gga tgt cag aag      768
Leu Asp Phe Phe Pro Asn Gly Gly Lys Glu Met Pro Gly Cys Gln Lys         
                245                 250                 255             

aac att ctc tct cag atc gtt gac ata gat ggg atc tgg gaa ggg acc      816
Asn Ile Leu Ser Gln Ile Val Asp Ile Asp Gly Ile Trp Glu Gly Thr         
            260                 265                 270                 

cgt gac ttt gtg gcc tgt aat cac tta aga agc tac aag tat tac tct      864
Arg Asp Phe Val Ala Cys Asn His Leu Arg Ser Tyr Lys Tyr Tyr Ser         
        275                 280                 285                     

gat agc atc ctt aac ccc gat ggc ttt gca gga ttc cct tgt gcc tct      912
Asp Ser Ile Leu Asn Pro Asp Gly Phe Ala Gly Phe Pro Cys Ala Ser         
    290                 295                 300                         

tac agt gtt ttc tct gca aac aag tgc ttc ccc tgc ccc agt gaa ggc      960
Tyr Ser Val Phe Ser Ala Asn Lys Cys Phe Pro Cys Pro Ser Glu Gly         
305                 310                 315                 320         

tgc cca cag atg ggt cat tat gct gac aga ttt cct gga aaa aca aac     1008
Cys Pro Gln Met Gly His Tyr Ala Asp Arg Phe Pro Gly Lys Thr Asn         
                325                 330                 335             

gga gtg ggc cag ata ttt tat cta aac act ggt gat gcc acc aac ttt     1056
Gly Val Gly Gln Ile Phe Tyr Leu Asn Thr Gly Asp Ala Thr Asn Phe         
            340                 345                 350                 

gcc cgt tgg agg tat aag gta gct gtc acg ctg tct gga agg aag gtt     1104
Ala Arg Trp Arg Tyr Lys Val Ala Val Thr Leu Ser Gly Arg Lys Val         
        355                 360                 365                     

aca gga cac gtg cta gtg acc ttg ttt gga aat aaa ggg aat tct aaa     1152
Thr Gly His Val Leu Val Thr Leu Phe Gly Asn Lys Gly Asn Ser Lys         
    370                 375                 380                         

caa tat gaa att ttc aag ggc act ctc caa ccc gac agc act cac tcc     1200
Gln Tyr Glu Ile Phe Lys Gly Thr Leu Gln Pro Asp Ser Thr His Ser         
385                 390                 395                 400         

aac gaa ttt gac tct gat gtg gat gtt gga gat ttg cag aag gtt aaa     1248
Asn Glu Phe Asp Ser Asp Val Asp Val Gly Asp Leu Gln Lys Val Lys         
                405                 410                 415             

ttt att tgg tac aac cgg gtg atc aac cca act cta ccc aga gtg gga     1296
Phe Ile Trp Tyr Asn Arg Val Ile Asn Pro Thr Leu Pro Arg Val Gly         
            420                 425                 430                 

gcg tcc aag atc atg gtg gaa aga aac gac gga aaa gtg ttc aat ttc     1344
Ala Ser Lys Ile Met Val Glu Arg Asn Asp Gly Lys Val Phe Asn Phe         
        435                 440                 445                     

tgt agt caa gaa act gtg agg gaa gat att ctg ctc act ctt acc ccg     1392
Cys Ser Gln Glu Thr Val Arg Glu Asp Ile Leu Leu Thr Leu Thr Pro         
    450                 455                 460                         

tgt tag                                                             1398
Cys                                                                     
465                                                                     


<210>  3
<211>  465
<212>  PRT
<213>  Felis sp.

<400>  3

Met Leu Leu Ile Trp Thr Leu Ser Leu Leu Leu Gly Ala Val Val Gly 
1               5                   10                  15      


Lys Glu Ile Cys Phe Pro Arg Leu Gly Cys Phe Ser Asp Asp Ala Pro 
            20                  25                  30          


Trp Ala Gly Ile Ala Gln Arg Pro Leu Lys Ile Leu Pro Trp Pro Pro 
        35                  40                  45              


Lys Asp Val Asn Thr Arg Phe Leu Leu Tyr Thr Asn Glu Asn Pro Asn 
    50                  55                  60                  


Asn Phe Glu Glu Ile Ile Ala Asp Glu Ser Thr Ile Met Ser Ser Asn 
65                  70                  75                  80  


Phe Asn Thr Asp Arg Lys Thr Arg Phe Ile Ile His Gly Phe Ile Asp 
                85                  90                  95      


Lys Gly Glu Glu Asn Trp Leu Ser Lys Ile Cys Lys Asn Leu Phe Thr 
            100                 105                 110         


Val Glu Ser Val Asn Cys Ile Cys Val Asp Trp Lys Ser Gly Ser Lys 
        115                 120                 125             


Thr Gly Tyr Thr Gln Ala Ser Gln Asn Ile Arg Ile Val Gly Ala Glu 
    130                 135                 140                 


Val Ala Tyr Phe Val Glu Val Leu Gln Ser Ala Phe Gly Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Val His Ile Ile Gly His Ser Leu Gly Ala His Ala Ala Gly 
                165                 170                 175     


Glu Ala Gly Arg Arg Ile Asn Gly Thr Ala Gly Arg Ile Thr Gly Leu 
            180                 185                 190         


Asp Pro Ala Glu Pro Cys Phe Glu Gly Thr Pro Asp Leu Val Arg Leu 
        195                 200                 205             


Asp Pro Ser Asp Ala Leu Phe Val Asp Val Ile His Thr Asp Ala Ala 
    210                 215                 220                 


Pro Ile Ile Pro Asn Met Gly Phe Gly Met Ser Gln Thr Val Gly His 
225                 230                 235                 240 


Leu Asp Phe Phe Pro Asn Gly Gly Lys Glu Met Pro Gly Cys Gln Lys 
                245                 250                 255     


Asn Ile Leu Ser Gln Ile Val Asp Ile Asp Gly Ile Trp Glu Gly Thr 
            260                 265                 270         


Arg Asp Phe Val Ala Cys Asn His Leu Arg Ser Tyr Lys Tyr Tyr Ser 
        275                 280                 285             


Asp Ser Ile Leu Asn Pro Asp Gly Phe Ala Gly Phe Pro Cys Ala Ser 
    290                 295                 300                 


Tyr Ser Val Phe Ser Ala Asn Lys Cys Phe Pro Cys Pro Ser Glu Gly 
305                 310                 315                 320 


Cys Pro Gln Met Gly His Tyr Ala Asp Arg Phe Pro Gly Lys Thr Asn 
                325                 330                 335     


Gly Val Gly Gln Ile Phe Tyr Leu Asn Thr Gly Asp Ala Thr Asn Phe 
            340                 345                 350         


Ala Arg Trp Arg Tyr Lys Val Ala Val Thr Leu Ser Gly Arg Lys Val 
        355                 360                 365             


Thr Gly His Val Leu Val Thr Leu Phe Gly Asn Lys Gly Asn Ser Lys 
    370                 375                 380                 


Gln Tyr Glu Ile Phe Lys Gly Thr Leu Gln Pro Asp Ser Thr His Ser 
385                 390                 395                 400 


Asn Glu Phe Asp Ser Asp Val Asp Val Gly Asp Leu Gln Lys Val Lys 
                405                 410                 415     


Phe Ile Trp Tyr Asn Arg Val Ile Asn Pro Thr Leu Pro Arg Val Gly 
            420                 425                 430         


Ala Ser Lys Ile Met Val Glu Arg Asn Asp Gly Lys Val Phe Asn Phe 
        435                 440                 445             


Cys Ser Gln Glu Thr Val Arg Glu Asp Ile Leu Leu Thr Leu Thr Pro 
    450                 455                 460                 


Cys 
465 


<210>  4
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial Sequence, RACE5 primer


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  h is a, c, or t

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  r is a or g

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  y is c or t

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  r is a or g

<400>  4
gatcctgccc tggagccchr aggaygtsra                                      30


<210>  5
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial Sequence, UPM primer

<400>  5
ctaatacgac tcactatagg gcaagcagtg gtatcaacgc agagt                     45


<210>  6
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence, UPM primer

<400>  6
ctaatacgac tcactatagg gc                                              22


<210>  7
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence, Kc616 primer

<400>  7
cacccttctg cccccacaat ccg                                             23


<210>  8
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence, Kc626 primer

<400>  8
aagaattcag ccaccatgct gctaatctgg acacta                               36


<210>  9
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence, Kc630 primer

<400>  9
tcgcggccgc tcaacacgga gtaagagtga gcaga                                35


<210>  10
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence, fpl-4_xho1Stop primer

<400>  10
gctcgagcta ctatgcacac ggggtaagag tg                                   32


<210>  11
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence, fpl-3_HindIII primer

<400>  11
caagcttacc atggtgctaa tctggacact atc                                  33


<210>  12
<211>  465
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Met Leu Met Leu Trp Thr Phe Ala Val Leu Leu Gly Ala Val Ala Gly 
1               5                   10                  15      


Lys Glu Val Cys Phe Asp Lys Leu Gly Cys Phe Ser Asp Asp Ala Pro 
            20                  25                  30          


Trp Ser Gly Thr Ile Asp Arg Pro Leu Lys Ala Leu Pro Trp Ser Pro 
        35                  40                  45              


Ala Gln Ile Asn Thr Arg Phe Leu Leu Tyr Thr Asn Glu Asn Gln Asp 
    50                  55                  60                  


Asn Tyr Gln Lys Ile Thr Ser Asp Ala Ser Ser Ile Arg Asn Ser Asn 
65                  70                  75                  80  


Phe Lys Thr Asn Arg Lys Thr Arg Ile Ile Ile His Gly Phe Ile Asp 
                85                  90                  95      


Lys Gly Glu Glu Asn Trp Leu Ser Asp Met Cys Lys Asn Met Phe Lys 
            100                 105                 110         


Val Glu Ser Val Asn Cys Ile Cys Val Asp Trp Lys Gly Gly Ser Arg 
        115                 120                 125             


Ala Thr Tyr Thr Gln Ala Thr Gln Asn Val Arg Val Val Gly Ala Glu 
    130                 135                 140                 


Val Ala Leu Leu Val Asn Val Leu Lys Ser Asp Leu Gly His Pro Pro 
145                 150                 155                 160 


Asp Asn Val His Leu Ile Gly His Ser Leu Gly Ser His Val Ala Gly 
                165                 170                 175     


Glu Ala Gly Lys Arg Thr Phe Gly Ala Ile Gly Arg Ile Thr Gly Leu 
            180                 185                 190         


Asp Ala Ala Glu Pro Tyr Phe Gln Gly Thr Pro Glu Glu Val Arg Leu 
        195                 200                 205             


Asp Pro Thr Asp Ala Gln Phe Val Asp Ala Ile His Thr Asp Ala Ala 
    210                 215                 220                 


Pro Ile Ile Pro Asn Leu Gly Phe Gly Met Ser Gln Thr Val Gly His 
225                 230                 235                 240 


Leu Asp Phe Phe Pro Asn Gly Gly Met Glu Met Pro Gly Cys Gln Lys 
                245                 250                 255     


Asn Ile Leu Ser Gln Ile Val Asp Ile Asp Gly Ile Trp Glu Gly Thr 
            260                 265                 270         


Arg Asp Phe Ala Ala Cys Asn His Leu Arg Ser Tyr Lys Tyr Tyr Thr 
        275                 280                 285             


Asp Ser Ile Val Asn Pro Thr Gly Phe Ser Gly Phe Ser Cys Ser Ser 
    290                 295                 300                 


Tyr Asn Val Phe Ser Ala Asn Lys Cys Phe Pro Cys Gly Ser Glu Gly 
305                 310                 315                 320 


Cys Pro Gln Met Gly His Tyr Ala Asp Lys Tyr Pro Gly Lys Thr Lys 
                325                 330                 335     


Glu Leu Tyr Gln Lys Phe Tyr Leu Asn Thr Gly Asp Lys Ser Asn Phe 
            340                 345                 350         


Ala Arg Trp Arg Tyr Gln Val Thr Val Thr Leu Ser Gly Gln Lys Val 
        355                 360                 365             


Thr Gly His Ile Leu Val Ser Leu Phe Gly Asn Gly Gly Asn Ser Lys 
    370                 375                 380                 


Gln Tyr Glu Val Phe Lys Gly Ser Leu His Pro Gly Asp Thr His Val 
385                 390                 395                 400 


Lys Glu Phe Asp Ser Asp Met Asp Val Gly Asp Leu Gln Lys Val Lys 
                405                 410                 415     


Phe Ile Trp Tyr Asn Asn Val Ile Asn Pro Thr Leu Pro Lys Val Gly 
            420                 425                 430         


Ala Ser Arg Ile Ser Val Glu Arg Asn Asp Gly Arg Val Phe Asn Phe 
        435                 440                 445             


Cys Ser Gln Asp Thr Val Arg Glu Asp Val Leu Leu Thr Leu Ser Ala 
    450                 455                 460                 


Cys 
465 


<210>  13
<211>  465
<212>  PRT
<213>  Mus musculus

<400>  13

Met Leu Met Leu Trp Thr Phe Ala Val Leu Leu Gly Ala Val Ala Gly 
1               5                   10                  15      


Arg Glu Val Cys Phe Asp Lys Leu Gly Cys Phe Ser Asp Asp Ala Pro 
            20                  25                  30          


Trp Ser Gly Thr Leu Asp Arg Pro Leu Lys Ala Leu Pro Trp Ser Pro 
        35                  40                  45              


Ala Gln Ile Asn Thr Arg Phe Leu Leu Tyr Thr Asn Glu Asn Pro Asp 
    50                  55                  60                  


Asn Tyr Gln Leu Ile Thr Ser Asp Ala Ser Asn Ile Arg Asn Ser Asn 
65                  70                  75                  80  


Phe Arg Thr Asn Arg Lys Thr Arg Ile Ile Ile His Gly Phe Ile Asp 
                85                  90                  95      


Lys Gly Glu Glu Asn Trp Leu Ser Asp Met Cys Lys Asn Met Phe Arg 
            100                 105                 110         


Val Glu Ser Val Asn Cys Ile Cys Val Asp Trp Lys Gly Gly Ser Arg 
        115                 120                 125             


Thr Thr Tyr Thr Gln Ala Thr Gln Asn Val Arg Val Val Gly Ala Glu 
    130                 135                 140                 


Val Ala Leu Leu Val Asn Val Leu Gln Ser Asp Leu Gly Tyr Ser Leu 
145                 150                 155                 160 


Asn Asn Val His Leu Ile Gly His Ser Leu Gly Ser His Ile Ala Gly 
                165                 170                 175     


Glu Ala Gly Lys Arg Thr Phe Gly Ala Ile Gly Arg Ile Thr Gly Leu 
            180                 185                 190         


Asp Pro Ala Glu Pro Tyr Phe Gln Gly Thr Pro Glu Glu Val Arg Leu 
        195                 200                 205             


Asp Pro Thr Asp Ala Gln Phe Val Asp Ala Ile His Thr Asp Ala Gly 
    210                 215                 220                 


Pro Ile Ile Pro Asn Leu Gly Phe Gly Met Ser Gln Thr Val Gly His 
225                 230                 235                 240 


Leu Asp Phe Phe Pro Asn Gly Gly Ile Glu Met Pro Gly Cys Gln Lys 
                245                 250                 255     


Asn Ile Leu Ser Gln Ile Val Asp Ile Asp Gly Ile Trp Glu Gly Thr 
            260                 265                 270         


Arg Asn Phe Ala Ala Cys Asn His Leu Arg Ser Tyr Lys Phe Tyr Thr 
        275                 280                 285             


Asp Ser Ile Val Asn Pro Thr Gly Phe Ala Gly Phe Ser Cys Ser Ser 
    290                 295                 300                 


Tyr Ser Leu Phe Thr Ala Asn Lys Cys Phe Pro Cys Gly Ser Gly Gly 
305                 310                 315                 320 


Cys Pro Gln Met Gly His Tyr Ala Asp Arg Tyr Pro Gly Lys Thr Ser 
                325                 330                 335     


Arg Leu Tyr Gln Thr Phe Tyr Leu Asn Thr Gly Asp Lys Ser Asn Phe 
            340                 345                 350         


Ala Arg Trp Arg Tyr Gln Val Thr Val Thr Leu Ser Gly Gln Lys Val 
        355                 360                 365             


Thr Gly His Ile Leu Val Ser Leu Phe Gly Asn Gly Gly Asn Ser Lys 
    370                 375                 380                 


Gln Tyr Glu Val Phe Lys Gly Ser Leu Gln Pro Gly Thr Ser His Val 
385                 390                 395                 400 


Asn Glu Phe Asp Ser Asp Val Asp Val Gly Asp Leu Gln Lys Val Lys 
                405                 410                 415     


Phe Ile Trp Tyr Asn Asn Val Ile Asn Pro Thr Leu Pro Lys Val Gly 
            420                 425                 430         


Ala Ser Arg Ile Thr Val Glu Arg Asn Asp Gly Arg Val Phe Asn Phe 
        435                 440                 445             


Cys Ser Gln Glu Thr Val Arg Glu Asp Val Leu Leu Thr Leu Ser Pro 
    450                 455                 460                 


Cys 
465 


<210>  14
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Leu Pro Leu Trp Thr Leu Ser Leu Leu Leu Gly Ala Val Ala Gly 
1               5                   10                  15      


Lys Glu Val Cys Tyr Glu Arg Leu Gly Cys Phe Ser Asp Asp Ser Pro 
            20                  25                  30          


Trp Ser Gly Ile Thr Glu Arg Pro Leu His Ile Leu Pro Trp Ser Pro 
        35                  40                  45              


Lys Asp Val Asn Thr Arg Phe Leu Leu Tyr Thr Asn Glu Asn Pro Asn 
    50                  55                  60                  


Asn Phe Gln Glu Val Ala Ala Asp Ser Ser Ser Ile Ser Gly Ser Asn 
65                  70                  75                  80  


Phe Lys Thr Asn Arg Lys Thr Arg Phe Ile Ile His Gly Phe Ile Asp 
                85                  90                  95      


Lys Gly Glu Glu Asn Trp Leu Ala Asn Val Cys Lys Asn Leu Phe Lys 
            100                 105                 110         


Val Glu Ser Val Asn Cys Ile Cys Val Asp Trp Lys Gly Gly Ser Arg 
        115                 120                 125             


Thr Gly Tyr Thr Gln Ala Ser Gln Asn Ile Arg Ile Val Gly Ala Glu 
    130                 135                 140                 


Val Ala Tyr Phe Val Glu Phe Leu Gln Ser Ala Phe Gly Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Val His Val Ile Gly His Ser Leu Gly Ala His Ala Ala Gly 
                165                 170                 175     


Glu Ala Gly Arg Arg Thr Asn Gly Thr Ile Gly Arg Ile Thr Gly Leu 
            180                 185                 190         


Asp Pro Ala Glu Pro Cys Phe Gln Gly Thr Pro Glu Leu Val Arg Leu 
        195                 200                 205             


Asp Pro Ser Asp Ala Lys Phe Val Asp Val Ile His Thr Asp Gly Ala 
    210                 215                 220                 


Pro Ile Val Pro Asn Leu Gly Phe Gly Met Ser Gln Val Val Gly His 
225                 230                 235                 240 


Leu Asp Phe Phe Pro Asn Gly Gly Val Glu Met Pro Gly Cys Lys Lys 
                245                 250                 255     


Asn Ile Leu Ser Gln Ile Val Asp Ile Asp Gly Ile Trp Glu Gly Thr 
            260                 265                 270         


Arg Asp Phe Ala Ala Cys Asn His Leu Arg Ser Tyr Lys Tyr Tyr Thr 
        275                 280                 285             


Asp Ser Ile Val Asn Pro Asp Gly Phe Ala Gly Phe Pro Cys Ala Ser 
    290                 295                 300                 


Tyr Asn Val Phe Thr Ala Asn Lys Cys Phe Pro Cys Pro Ser Gly Gly 
305                 310                 315                 320 


Cys Pro Gln Met Gly His Tyr Ala Asp Arg Tyr Pro Gly Lys Thr Asn 
                325                 330                 335     


Asp Val Gly Gln Lys Phe Tyr Leu Asp Thr Gly Asp Ala Ser Asn Phe 
            340                 345                 350         


Ala Arg Trp Arg Tyr Lys Val Ser Val Thr Leu Ser Gly Lys Lys Val 
        355                 360                 365             


Thr Gly His Ile Leu Val Ser Leu Phe Gly Asn Lys Gly Asn Ser Lys 
    370                 375                 380                 


Gln Tyr Glu Ile Phe Lys Gly Thr Leu Lys Pro Asp Ser Thr His Ser 
385                 390                 395                 400 


Asn Glu Phe Asp Ser Asp Val Asp Val Gly Asp Leu Gln Met Val Lys 
                405                 410                 415     


Phe Ile Trp Tyr Asn Asn Val Ile Asn Pro Thr Leu Pro Arg Val Gly 
            420                 425                 430         


Ala Ser Lys Ile Ile Val Glu Thr Asn Val Gly Lys Gln Phe Asn Phe 
        435                 440                 445             


Cys Ser Pro Glu Thr Val Arg Glu Glu Val Leu Leu Thr Leu Thr Pro 
    450                 455                 460                 


Cys 
465 


<210>  15
<211>  461
<212>  PRT
<213>  Equus caballus

<400>  15

Trp Thr Leu Ser Leu Leu Leu Gly Ala Val Val Gly Asn Glu Val Cys 
1               5                   10                  15      


Tyr Glu Arg Leu Gly Cys Phe Ser Asp Asp Ser Pro Trp Ala Gly Ile 
            20                  25                  30          


Val Glu Arg Pro Leu Lys Ile Leu Pro Trp Ser Pro Glu Lys Val Asn 
        35                  40                  45              


Thr Arg Phe Leu Leu Tyr Thr Asn Glu Asn Pro Asp Asn Phe Gln Glu 
    50                  55                  60                  


Ile Val Ala Asp Pro Ser Thr Ile Gln Ser Ser Asn Phe Asn Thr Gly 
65                  70                  75                  80  


Arg Lys Thr Arg Phe Ile Ile His Gly Phe Ile Asp Lys Gly Glu Glu 
                85                  90                  95      


Ser Trp Leu Ser Thr Met Cys Gln Asn Met Phe Lys Val Glu Ser Val 
            100                 105                 110         


Asn Cys Ile Cys Val Asp Trp Lys Ser Gly Ser Arg Thr Ala Tyr Ser 
        115                 120                 125             


Gln Ala Ser Gln Asn Val Arg Ile Val Gly Ala Glu Val Ala Tyr Leu 
    130                 135                 140                 


Val Gly Val Leu Gln Ser Ser Phe Asp Tyr Ser Pro Ser Asn Val His 
145                 150                 155                 160 


Ile Ile Gly His Ser Leu Gly Ser His Ala Ala Gly Glu Ala Gly Arg 
                165                 170                 175     


Arg Thr Asn Gly Ala Val Gly Arg Ile Thr Gly Leu Asp Pro Ala Glu 
            180                 185                 190         


Pro Cys Phe Gln Gly Thr Pro Glu Leu Val Arg Leu Asp Pro Ser Asp 
        195                 200                 205             


Ala Gln Phe Val Asp Val Ile His Thr Asp Ile Ala Pro Phe Ile Pro 
    210                 215                 220                 


Asn Leu Gly Phe Gly Met Ser Gln Thr Ala Gly His Leu Asp Phe Phe 
225                 230                 235                 240 


Pro Asn Gly Gly Lys Glu Met Pro Gly Cys Gln Lys Asn Val Leu Ser 
                245                 250                 255     


Gln Ile Val Asp Ile Asp Gly Ile Trp Gln Gly Thr Arg Asp Phe Ala 
            260                 265                 270         


Ala Cys Asn His Leu Arg Ser Tyr Lys Tyr Tyr Thr Asp Ser Ile Leu 
        275                 280                 285             


Asn Pro Asp Gly Phe Ala Gly Phe Ser Cys Ala Ser Tyr Ser Asp Phe 
    290                 295                 300                 


Thr Ala Asn Lys Cys Phe Pro Cys Ser Ser Glu Gly Cys Pro Gln Met 
305                 310                 315                 320 


Gly His Tyr Ala Asp Arg Phe Pro Gly Arg Thr Lys Gly Val Gly Gln 
                325                 330                 335     


Leu Phe Tyr Leu Asn Thr Gly Asp Ala Ser Asn Phe Ala Arg Trp Arg 
            340                 345                 350         


Tyr Arg Val Asp Val Thr Leu Ser Gly Lys Lys Val Thr Gly His Val 
        355                 360                 365             


Leu Val Ser Leu Phe Gly Asn Lys Gly Asn Ser Arg Gln Tyr Glu Ile 
    370                 375                 380                 


Phe Gln Gly Thr Leu Lys Pro Asp Asn Thr Tyr Ser Asn Glu Phe Asp 
385                 390                 395                 400 


Ser Asp Val Glu Val Gly Asp Leu Glu Lys Val Lys Phe Ile Trp Tyr 
                405                 410                 415     


Asn Asn Val Ile Asn Leu Thr Leu Pro Lys Val Gly Ala Ser Lys Ile 
            420                 425                 430         


Thr Val Glu Arg Asn Asp Gly Ser Val Phe Asn Phe Cys Ser Glu Glu 
        435                 440                 445             


Thr Val Arg Glu Asp Val Leu Leu Thr Leu Thr Ala Cys 
    450                 455                 460     


<210>  16
<211>  467
<212>  PRT
<213>  Canis familiaris

<400>  16

Met Val Ser Ile Trp Thr Ile Ala Leu Phe Leu Leu Gly Ala Ala Lys 
1               5                   10                  15      


Ala Lys Glu Val Cys Tyr Glu Gln Ile Gly Cys Phe Ser Asp Ala Glu 
            20                  25                  30          


Pro Trp Ala Gly Thr Ala Ile Arg Pro Leu Lys Val Leu Pro Trp Ser 
        35                  40                  45              


Pro Glu Arg Ile Gly Thr Arg Phe Leu Leu Tyr Thr Asn Lys Asn Pro 
    50                  55                  60                  


Asn Asn Phe Gln Thr Leu Leu Pro Ser Asp Pro Ser Thr Ile Glu Ala 
65                  70                  75                  80  


Ser Asn Phe Gln Thr Asp Lys Lys Thr Arg Phe Thr Ile His Gly Phe 
                85                  90                  95      


Ile Asn Lys Gly Glu Glu Asn Trp Leu Leu Asp Met Cys Lys Asn Met 
            100                 105                 110         


Phe Lys Val Glu Glu Val Asn Cys Ile Cys Val Asp Trp Lys Lys Gly 
        115                 120                 125             


Ser Gln Thr Ser Tyr Thr Gln Ala Ala Asn Asn Val Arg Val Val Gly 
    130                 135                 140                 


Ala Gln Val Ala Gln Met Leu Ser Met Leu Ser Ala Asn Tyr Ser Tyr 
145                 150                 155                 160 


Ser Pro Ser Gln Val Gln Leu Ile Gly His Ser Leu Gly Ala His Val 
                165                 170                 175     


Ala Gly Glu Ala Gly Ser Arg Thr Pro Gly Leu Gly Arg Ile Thr Gly 
            180                 185                 190         


Leu Asp Pro Val Glu Ala Ser Phe Gln Gly Thr Pro Glu Glu Val Arg 
        195                 200                 205             


Leu Asp Pro Thr Asp Ala Asp Phe Val Asp Val Ile His Thr Asp Ala 
    210                 215                 220                 


Ala Pro Leu Ile Pro Phe Leu Gly Phe Gly Thr Ser Gln Gln Met Gly 
225                 230                 235                 240 


His Leu Asp Phe Phe Pro Asn Gly Gly Glu Glu Met Pro Gly Cys Lys 
                245                 250                 255     


Lys Asn Ala Leu Ser Gln Ile Val Asn Leu Asp Gly Ile Trp Glu Gly 
            260                 265                 270         


Thr Arg Asp Phe Val Ala Cys Asn His Leu Arg Ser Tyr Lys Tyr Tyr 
        275                 280                 285             


Ser Glu Ser Ile Leu Asn Pro Asp Gly Phe Ala Ser Tyr Pro Cys Ala 
    290                 295                 300                 


Ser Tyr Arg Ala Phe Glu Ser Asn Lys Cys Phe Pro Cys Pro Asp Gln 
305                 310                 315                 320 


Gly Cys Pro Gln Met Gly His Tyr Ala Asp Lys Phe Ala Val Lys Thr 
                325                 330                 335     


Ser Asp Glu Thr Gln Lys Tyr Phe Leu Asn Thr Gly Asp Ser Ser Asn 
            340                 345                 350         


Phe Ala Arg Trp Arg Tyr Gly Val Ser Ile Thr Leu Ser Gly Lys Arg 
        355                 360                 365             


Ala Thr Gly Gln Ala Lys Val Ala Leu Phe Gly Ser Lys Gly Asn Thr 
    370                 375                 380                 


His Gln Phe Asn Ile Phe Lys Gly Ile Leu Lys Pro Gly Ser Thr His 
385                 390                 395                 400 


Ser Asn Glu Phe Asp Ala Lys Leu Asp Val Gly Thr Ile Glu Lys Val 
                405                 410                 415     


Lys Phe Leu Trp Asn Asn Asn Val Val Asn Pro Thr Phe Pro Lys Val 
            420                 425                 430         


Gly Ala Ala Lys Ile Thr Val Gln Lys Gly Glu Glu Lys Thr Val His 
        435                 440                 445             


Ser Phe Cys Ser Glu Ser Thr Val Arg Glu Asp Val Leu Leu Thr Leu 
    450                 455                 460                 


Thr Pro Cys 
465         


