                         SEQUENCE LISTING

<110>  The Rockefeller University
 
<120>  Antibodies Specific for the Protofibril form of Beta-Amyloid 
       Protein

<130>  70413.00057/RU812

<140>  N/A
<141>  2008-11-14

<150>  60/988,481
<151>  2007-11-16

<150>  61/019,747
<151>  2008-01-08

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  2
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe 
            20  


<210>  3
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  3

Phe Arg His Asp Ser Gly Tyr Glu Val 
1               5                   


<210>  4
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe 
1               5                   10          


<210>  5
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  5

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  6
<211>  339
<212>  DNA
<213>  Mus musculus

<400>  6
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctggtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct atacagtttc caaccgattt      180

tctggggtcc cggacaggtt cagtggcagt ggatcagggt cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaaatac atttgttcct      300

tggacgttcg gtggaggcac caagctggaa atcaaacgg                             339


<210>  7
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  7

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  8
<211>  345
<212>  DNA
<213>  Mus musculus

<400>  8
caggtccagc tgcagcagtc tgggcctgag ctggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cacattcact gattatgcta tgcactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attagtacta agtatggtaa gacaaactac      180

aaccagaagt ttaagggcaa ggccacaatg actgttgaca aatcctccag cacagcctat      240

atggagcttg ccagattgac atctgaggat tctgccatct attactgtgc aagaggggac      300

gatggttatt cctggggtca aggaacctca gtcaccgtct cctca                      345


<210>  9
<211>  26
<212>  PRT
<213>  Mus musculus

<400>  9

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Gly 
            20                  25      


<210>  10
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  10

Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  11
<211>  36
<212>  PRT
<213>  Mus musculus

<400>  11

Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Ser Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
            20                  25                  30          


Val Tyr Phe Cys 
        35      


<210>  12
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  12

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  13

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  14
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  14

Thr Val Ser 
1           


<210>  15
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  15

Ser Gln Asn Thr Phe Val Pro Trp Thr 
1               5                   


<210>  16
<211>  23
<212>  PRT
<213>  Mus musculus

<400>  16

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys 
            20              


<210>  17
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  17

Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  15      


Val 
    


<210>  18
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  a variable heavy region for the isolated 13C3 or 13C3-like 
       antibodies

<400>  18

Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu 
1               5                   10                  15      


Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 
            20                  25                  30      


<210>  19
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  19

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  20
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  20

Gly Ser Gly Tyr Thr Phe Thr Asp Tyr Ala 
1               5                   10  


<210>  21
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  21

Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Gln Lys Phe Lys Gly 
1               5                   10                  15      


Lys 
    


<210>  22
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  22

Gly Asp Asp Gly Tyr Ser 
1               5       


<210>  23
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His 
1               5                   10              


<210>  24
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His 
1               5                   10              


<210>  25
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  25

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln 
1               5                   10              


<210>  26
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  26

Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10              


<210>  27
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  27

Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
1               5                   10              


<210>  28
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  28

His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val 
1               5                   10              


<210>  29
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  29

Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe 
1               5                   10              


<210>  30
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  30

Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe 
1               5                   10              


<210>  31
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  31

Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala 
1               5                   10              


<210>  32
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  32

Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu 
1               5                   10              


<210>  33
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp 
1               5                   10              


<210>  34
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  34

Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val 
1               5                   10              


<210>  35
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  35

His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly 
1               5                   10              


<210>  36
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  36

His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser 
1               5                   10              


<210>  37
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  37

Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn 
1               5                   10              


<210>  38
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  38

Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys 
1               5                   10              


<210>  39
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  39

Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly 
1               5                   10              


<210>  40
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  40

Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala 
1               5                   10              


<210>  41
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  41

Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile 
1               5                   10              


<210>  42
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  42

Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
1               5                   10              


<210>  43
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  43

Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
1               5                   10              


<210>  44
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  44

Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu 
1               5                   10              


<210>  45
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  45

Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met 
1               5                   10              


<210>  46
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  46

Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val 
1               5                   10              


<210>  47
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  47

Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly 
1               5                   10              


<210>  48
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  48

Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly 
1               5                   10              


<210>  49
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  49

Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val 
1               5                   10              


<210>  50
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  50

Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val 
1               5                   10              


<210>  51
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  51

Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile 
1               5                   10              


<210>  52
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  52

Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala 
1               5                   10              


