                         SEQUENCE LISTING

<110>  University of South Florida
       Mohapatra, Shyam
       Xu, Weidong
       Kong, Xiaoyuan
       Wang, Xiaoqin
       Mohapatra, Subhra
 
<120>  Methods and Compositions for Reducing Activity of the Atrial 
       Natriuretic Peptide Receptor and for Treatment of Diseases

<130>  USF-240XC2 PCT

<150>  11/998,792
<151>  2007-11-30

<150>  60/796,278
<151>  2006-04-28

<150>  60/521,072
<151>  2004-02-17

<150>  11/059,814
<151>  2005-02-17

<150>  11/799,225
<151>  2007-04-30

<160>  28    

<170>  PatentIn version 3.3

<210>  1
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  1

Asn Pro Met Tyr Asn Ala Val Ser Asn Ala Asp Leu Met Asp Phe Lys 
1               5                   10                  15      


Asn Leu Leu Asp His Leu Glu Glu Lys Met Pro Leu Glu Asp 
            20                  25                  30  


<210>  2
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Val Val Pro Pro Gln Val Leu Ser Glu Pro Asn Glu Glu Ala Gly 
1               5                   10                  15      


Ala Ala Leu Ser Pro Leu Pro Glu Val Pro Pro Trp Thr Gly Glu Val 
            20                  25                  30          


Ser Pro Ala Gln Arg 
        35          


<210>  3
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Ser Asp Arg Ser Ala Leu Leu Lys Ser Lys Leu Arg Ala Leu Leu 
1               5                   10                  15      


Thr Ala Pro Arg 
            20  


<210>  4
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
            20                  25              


<210>  5
<211>  29
<212>  PRT
<213>  Mus musculus

<400>  5

Gly Ser Pro Trp Asp Pro Ser Asp Arg Ser Ala Leu Leu Lys Ser Lys 
1               5                   10                  15      


Leu Arg Ala Leu Leu Ala Gly Pro Arg Ser Leu Arg Arg 
            20                  25                  


<210>  6
<211>  37
<212>  PRT
<213>  Mus musculus

<400>  6

Val Ser Asn Thr Asp Leu Met Asp Phe Lys Asn Leu Leu Asp His Leu 
1               5                   10                  15      


Glu Glu Lys Met Pro Val Glu Asp Glu Val Met Pro Pro Gln Ala Leu 
            20                  25                  30          


Ser Glu Gln Thr Glu 
        35          


<210>  7
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Ser Phe Ser Thr Thr Thr Val Ser Phe Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gln Leu Leu Gly Gln Thr Arg Ala Asn Pro Met Tyr Asn Ala Val 
            20                  25                  30          


Ser Asn Ala Asp Leu Met Asp Phe Lys Asn Leu Leu Asp His Leu Glu 
        35                  40                  45              


Glu Lys Met Pro Leu Glu Asp Glu Val Val Pro Pro Gln Val Leu Ser 
    50                  55                  60                  


Glu Pro Asn Glu Glu Ala Gly Ala Ala Leu Ser Pro Leu Pro Glu Val 
65                  70                  75                  80  


Pro Pro Trp Thr Gly Glu Val Ser Pro Ala Gln Arg Asp Gly Gly Ala 
                85                  90                  95      


Leu Gly Arg Gly Pro Trp Asp Ser Ser Asp Arg Ser Ala Leu Leu Lys 
            100                 105                 110         


Ser Lys Leu Arg Ala Leu Leu Thr Ala Pro Arg Ser Leu Arg Arg Ser 
        115                 120                 125             


Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu 
    130                 135                 140                 


Gly Cys Asn Ser Phe Arg Tyr 
145                 150     


<210>  8
<211>  35
<212>  DNA
<213>  Mus musculus

<400>  8
gacggcaagc ttactatggg cagcccctgg gaccc                                35


<210>  9
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  9
acccccctcg agttattatc ttcgtaggct ccg                                  33


<210>  10
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  10
aatcctaagc ttagtatggt gtccaacaca gat                                  33


<210>  11
<211>  41
<212>  DNA
<213>  Mus musculus

<400>  11
tgcgaactcg agttactcag tctgctcact cagggcctgc g                         41


<210>  12
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  12
atgggcagcc cctgggaccc ctccgataga tctgccctct tgaaaagcaa actgagggct     60

ctgctcgctg gccctcggag cctacgaaga taa                                  93


<210>  13
<211>  117
<212>  DNA
<213>  Mus musculus

<400>  13
atggtgtcca acacagatct gatggatttc aagaacctgc tagaccacct ggaggagaag     60

atgccggtag aagatgaggt catgcccccg caggccctga gtgagcagac tgagtaa       117


<210>  14
<211>  845
<212>  DNA
<213>  Homo sapiens

<400>  14
tggcgaggga cagacgtagg ccaagagagg ggaaccagag aggaaccaga ggggagagac     60

agagcagcaa gcagtggatt gctccttgac gacgccagca tgagctcctt ctccaccacc    120

accgtgagct tcctcctttt actggcattc cagctcctag gtcagaccag agctaatccc    180

atgtacaatg ccgtgtccaa cgcagacctg atggatttca agaatttgct ggaccatttg    240

gaagaaaaga tgcctttaga agatgaggtc gtgcccccac aagtgctcag tgagccgaat    300

gaagaagcgg gggctgctct cagccccctc cctgaggtgc ctccctggac cggggaagtc    360

agcccagccc agagagatgg aggtgccctc gggcggggcc cctgggactc ctctgatcga    420

tctgccctcc taaaaagcaa gctgagggcg ctgctcactg cccctcggag cctgcggaga    480

tccagctgct tcgggggcag gatggacagg attggagccc agagcggact gggctgtaac    540

agcttccggt actgaagata acagccaggg aggacaagca gggctgggcc tagggacaga    600

ctgcaagagg ctcctgtccc ctggggtctc tgctgcattt gtgtcatctt gttgccatgg    660

agttgtgatc atcccatcta agctgcagct tcctgtcaac acttctcaca tcttatgcta    720

actgtagata aagtggtttg atggtgactt cctcgcctct cccaccccat gcattaaatt    780

ttaaggtaga acctcacctg ttactgaaag tggtttgaaa gtgaataaac ttcagcacca    840

tggac                                                                845


<210>  15
<211>  2583
<212>  DNA
<213>  Homo sapiens

<400>  15
ggatccattt gtctcgggct gctggctgcc tgccatttcc tcctctccac ccttatttgg     60

aggccctgac agctgagcca caaacaaacc aggggagctg ggcaccagca agcgtcaccc    120

tctgtttccc cgcacggtac cagcgtcgag gagaaagaat cctgaggcac ggcggtgaga    180

taaccaagga ctctttttta ctcttctcac acctttgaag tgggagcctc ttgagtcaaa    240

tcagtaagaa tgcggctctt gcagctgagg gtctgggggg ctgttggggc tgcccaaggc    300

agagaggggc tgtgacaagc cctgcggatg ataactttaa aagggcatct cctgctggct    360

tctcacttgg cagctttatc actgcaagtg acagaatggg gagggttctg tctctcctgc    420

gtgcttggag agctgggggg ctataaaaag aggcggcact gggcagctgg gagacaggga    480

cagacgtagg ccaagagagg ggaaccagag aggaaccaga ggggagagac agagcagcaa    540

gcagtggatt gctccttgac gacgccagca tgagctcctt ctccaccacc accgtgagct    600

tcctcctttt actggcattc cagctcctag gtcagaccag agctaatccc atgtacaatg    660

ccgtgtccaa cgcagacctg atggatttca aggtagggcc aggaaagcgg gtgcagtctg    720

gggccagggg gctttctgat gctgtgctca ctcctcttga tttcctccaa gtcagtgagg    780

tttatccctt tccctgtatt ttccttttct aaagaatttg ctggaccatt tggaagaaaa    840

gatgccttta gaagatgagg tcgtgccccc acaagtgctc agtgagccga atgaagaagc    900

gggggctgct ctcagccccc tccctgaggt gcctccctgg accggggaag tcagcccagc    960

ccagagagat ggaggtgccc tcgggcgggg cccctgggac tcctctgatc gatctgccct   1020

cctaaaaagc aagctgaggg cgctgctcac tgcccctcgg agcctgcgga gatccagctg   1080

cttcgggggc aggatggaca ggattggagc ccagagcgga ctgggctgta acagcttccg   1140

ggtaagagga actggggatg gaaatgggat gggatggaca ctactgggag acaccttcag   1200

caggaaaggg accaatgcag aagctcattc cctctcaagt ttctgcccca acacccagag   1260

tgccccatgg gtgtcaggac atgccatcta ttgtccttag ctagtctgct gagaaaatgc   1320

ttaaaaaaaa aagggggggg gctgggcacg gtcgtcacgc ctgtaatccc agcactttgg   1380

gaggccaggc agcggatcat gaggtcaaga gatcaagact atcctggcca acatggtgaa   1440

accccagctc tactaaaaat acaaaaatta gctgggtgtg tggcgggcac ctgtactctc   1500

agctacttgg gaggctgagg caggagaatc acttgaaccc aggaggcaga ggttgcagtg   1560

agcagagatc acgccactgc agtccagcct aggtgataga gcgagactgt ctcaaaaaaa   1620

aaaaaaaaag gccaggcgcg gtggctcacg cctgtaatcc cagcgctttg ggaggccaag   1680

gcgggtggat cacgaggtca ggagatggag accatcctgg ctaacacggt gaaaccccgt   1740

ctctactaaa aatacaaaaa attagccagg cgtggtggca ggcgcctgta agtcctagct   1800

actccggagg ctgaggcagg agaatggcgt gaacccggga ggcggagctt gcagtgagca   1860

gagatggcac cactgcactc cagcctgggc gacagagcaa gactccgtct caaaaaaaaa   1920

aaaaaaaaaa gcaactgcca ctagcactgg gaaattaaaa tattcataga gccaagttat   1980

ctttgcatgg ctgattagca gttcatattc ctccccagaa ttgcaagatc ctgaagggct   2040

taagtgaaat ttactctgat gagtaacttg cttatcaatt catgaagctc agagggtcat   2100

caggctgggg tgggggccgg tgggaagcag gtggtcagta atcaagttca gaggatgggc   2160

acactcatac atgaagctga cttttccagg acagccaggt caccaagcca gatatgtctg   2220

tgttctcttt gcagtactga agataacagc cagggaggac aagcagggct gggcctaggg   2280

acagactgca agaggctcct gtcccctggg gtctctgctg catttgtgtc atcttgttgc   2340

catggagttg tgatcatccc atctaagctg cagcttcctg tcaacacttc tcacatctta   2400

tgctaactgt agataaagtg gtttgatggt gacttcctcg cctctcccac cccatgcatt   2460

aaattttaag gtagaacctc acctgttact gaaagtggtt tgaaagtgaa taaacttcag   2520

caccatggac agaagacaaa tgcctgcgtt ggtgtgcttt ctttcttctt gggaagagaa   2580

ttc                                                                 2583


<210>  16
<211>  152
<212>  PRT
<213>  Mus musculus

<400>  16

Met Gly Ser Phe Ser Ile Thr Leu Gly Phe Phe Leu Val Leu Ala Phe 
1               5                   10                  15      


Trp Leu Pro Gly His Ile Gly Ala Asn Pro Val Tyr Ser Ala Val Ser 
            20                  25                  30          


Asn Thr Asp Leu Met Asp Phe Lys Asn Leu Leu Asp His Leu Glu Glu 
        35                  40                  45              


Lys Met Pro Val Glu Asp Glu Val Met Pro Pro Gln Ala Leu Ser Glu 
    50                  55                  60                  


Gln Thr Glu Glu Ala Gly Ala Ala Leu Ser Ser Leu Pro Glu Val Pro 
65                  70                  75                  80  


Pro Trp Thr Gly Glu Val Asn Pro Pro Leu Arg Asp Gly Ser Ala Leu 
                85                  90                  95      


Gly Arg Ser Pro Trp Asp Pro Ser Asp Arg Ser Ala Leu Leu Lys Ser 
            100                 105                 110         


Lys Leu Arg Ala Leu Leu Ala Gly Pro Arg Ser Leu Arg Arg Ser Ser 
        115                 120                 125             


Cys Phe Gly Gly Arg Ile Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly 
    130                 135                 140                 


Cys Asn Ser Phe Arg Tyr Arg Arg 
145                 150         


<210>  17
<211>  878
<212>  DNA
<213>  Mus musculus

<400>  17
caaaagctga gagagagaga gaaagaaacc agagtgggca gagacagcaa acatcagatc     60

gtgccccgac ccacgccagc atgggctcct tctccatcac cctgggcttc ttcctcgtct    120

tggccttttg gcttccaggc catattggag caaatcctgt gtacagtgcg gtgtccaaca    180

cagatctgat ggatttcaag aacctgctag accacctgga ggagaagatg ccggtagaag    240

atgaggtcat gcccccgcag gccctgagtg agcagactga ggaagcaggg gccgcactta    300

gctccctccc cgaggtgcct ccctggactg gggaggtcaa cccacctctg agagacggca    360

gtgctctagg gcgcagcccc tgggacccct ccgatagatc tgccctcttg aaaagcaaac    420

tgagggctct gctcgctggc cctcggagcc tacgaagatc cagctgcttc gggggtagga    480

ttgacaggat tggagcccag agtggactag gctgcaacag cttccggtac cgaagataac    540

agccaaggag gaaaaggcag tcgattctgc ttgagcagat cgcaaaagat cctaagccct    600

tgtggtgtgt cacgcagctt ggtcacattg ccactgtggc gtggtgaaca ccctcctgga    660

gctgcggctt cctgccttca tctatcacga tcgatgttaa atgtagatga gtggtctagt    720

ggggtcttgc ctctcccact ctgcatatta aggtagatcc tcaccctttt cagaaagcag    780

ttggaaaaaa aaaaaaagaa taaacttcag caccaaggac agacgccgag gccctgatgt    840

gcttctttgg cttctgccct cagttctttg ctctcccc                            878


<210>  18
<211>  1061
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Pro Gly Pro Arg Arg Pro Ala Gly Ser Arg Leu Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Pro Pro Leu Leu Leu Leu Leu Arg Gly Ser His Ala 
            20                  25                  30          


Gly Asn Leu Thr Val Ala Val Val Leu Pro Leu Ala Asn Thr Ser Tyr 
        35                  40                  45              


Pro Trp Ser Trp Ala Arg Val Gly Pro Ala Val Glu Leu Ala Leu Ala 
    50                  55                  60                  


Gln Val Lys Ala Arg Pro Asp Leu Leu Pro Gly Trp Thr Val Arg Thr 
65                  70                  75                  80  


Val Leu Gly Ser Ser Glu Asn Ala Leu Gly Val Cys Ser Asp Thr Ala 
                85                  90                  95      


Ala Pro Leu Ala Ala Val Asp Leu Lys Trp Glu His Asn Pro Ala Val 
            100                 105                 110         


Phe Leu Gly Pro Gly Cys Val Tyr Ala Ala Ala Pro Val Gly Arg Phe 
        115                 120                 125             


Thr Ala His Trp Arg Val Pro Leu Leu Thr Ala Gly Ala Pro Ala Leu 
    130                 135                 140                 


Gly Phe Gly Val Lys Asp Glu Tyr Ala Leu Thr Thr Arg Ala Gly Pro 
145                 150                 155                 160 


Ser Tyr Ala Lys Leu Gly Asp Phe Val Ala Ala Leu His Arg Arg Leu 
                165                 170                 175     


Gly Trp Glu Arg Gln Ala Leu Met Leu Tyr Ala Tyr Arg Pro Gly Asp 
            180                 185                 190         


Glu Glu His Cys Phe Phe Leu Val Glu Gly Leu Phe Met Arg Val Arg 
        195                 200                 205             


Asp Arg Leu Asn Ile Thr Val Asp His Leu Glu Phe Ala Glu Asp Asp 
    210                 215                 220                 


Leu Ser His Tyr Thr Arg Leu Leu Arg Thr Met Pro Arg Lys Gly Arg 
225                 230                 235                 240 


Val Ile Tyr Ile Cys Ser Ser Pro Asp Ala Phe Arg Thr Leu Met Leu 
                245                 250                 255     


Leu Ala Leu Glu Ala Gly Leu Cys Gly Glu Asp Tyr Val Phe Phe His 
            260                 265                 270         


Leu Asp Ile Phe Gly Gln Ser Leu Gln Gly Gly Gln Gly Pro Ala Pro 
        275                 280                 285             


Arg Arg Pro Trp Glu Arg Gly Asp Gly Gln Asp Val Ser Ala Arg Gln 
    290                 295                 300                 


Ala Phe Gln Ala Ala Lys Ile Ile Thr Tyr Lys Asp Pro Asp Asn Pro 
305                 310                 315                 320 


Glu Tyr Leu Glu Phe Leu Lys Gln Leu Lys His Leu Ala Tyr Glu Gln 
                325                 330                 335     


Phe Asn Phe Thr Met Glu Asp Val Leu Val Asn Thr Ile Pro Ala Ser 
            340                 345                 350         


Phe His Asp Gly Leu Leu Leu Tyr Ile Gln Ala Val Thr Glu Thr Leu 
        355                 360                 365             


Ala His Gly Gly Thr Val Thr Asp Gly Glu Asn Ile Thr Gln Arg Met 
    370                 375                 380                 


Trp Asn Arg Ser Phe Gln Gly Val Thr Gly Tyr Leu Lys Ile Asp Ser 
385                 390                 395                 400 


Ser Gly Asp Arg Glu Thr Asp Phe Ser Leu Trp Asp Met Asp Pro Glu 
                405                 410                 415     


Asn Gly Ala Phe Arg Val Val Leu Asn Tyr Asn Gly Thr Ser Gln Glu 
            420                 425                 430         


Leu Val Ala Val Ser Gly Arg Lys Leu Asn Trp Pro Leu Gly Tyr Pro 
        435                 440                 445             


Pro Pro Asp Ile Pro Lys Cys Gly Phe Asp Asn Glu Asp Pro Ala Cys 
    450                 455                 460                 


Asn Gln Asp His Leu Ser Thr Leu Glu Val Leu Ala Leu Val Gly Ser 
465                 470                 475                 480 


Leu Ser Leu Leu Gly Ile Leu Ile Val Ser Phe Phe Ile Tyr Arg Lys 
                485                 490                 495     


Met Gln Leu Glu Lys Glu Leu Ala Ser Glu Leu Trp Arg Val Arg Trp 
            500                 505                 510         


Glu Asp Val Glu Pro Ser Ser Leu Glu Arg His Leu Arg Ser Ala Gly 
        515                 520                 525             


Ser Arg Leu Thr Leu Ser Gly Arg Gly Ser Asn Tyr Gly Ser Leu Leu 
    530                 535                 540                 


Thr Thr Glu Gly Gln Phe Gln Val Phe Ala Lys Thr Ala Tyr Tyr Lys 
545                 550                 555                 560 


Gly Asn Leu Val Ala Val Lys Arg Val Asn Arg Lys Arg Ile Glu Leu 
                565                 570                 575     


Thr Arg Lys Val Leu Phe Glu Leu Lys His Met Arg Asp Val Gln Asn 
            580                 585                 590         


Glu His Leu Thr Arg Phe Val Gly Ala Cys Thr Asp Pro Pro Asn Ile 
        595                 600                 605             


Cys Ile Leu Thr Glu Tyr Cys Pro Arg Gly Ser Leu Gln Asp Ile Leu 
    610                 615                 620                 


Glu Asn Glu Ser Ile Thr Leu Asp Trp Met Phe Arg Tyr Ser Leu Thr 
625                 630                 635                 640 


Asn Asp Ile Val Lys Gly Met Leu Phe Leu His Asn Gly Ala Ile Cys 
                645                 650                 655     


Ser His Gly Asn Leu Lys Ser Ser Asn Cys Val Val Asp Gly Arg Phe 
            660                 665                 670         


Val Leu Lys Ile Thr Asp Tyr Gly Leu Glu Ser Phe Arg Asp Leu Asp 
        675                 680                 685             


Pro Glu Gln Gly His Thr Val Tyr Ala Lys Lys Leu Trp Thr Ala Pro 
    690                 695                 700                 


Glu Leu Leu Arg Met Ala Ser Pro Pro Val Arg Gly Ser Gln Ala Gly 
705                 710                 715                 720 


Asp Val Tyr Ser Phe Gly Ile Ile Leu Gln Glu Ile Ala Leu Arg Ser 
                725                 730                 735     


Gly Val Phe His Val Glu Gly Leu Asp Leu Ser Pro Lys Glu Ile Ile 
            740                 745                 750         


Glu Arg Val Thr Arg Gly Glu Gln Pro Pro Phe Arg Pro Ser Leu Ala 
        755                 760                 765             


Leu Gln Ser His Leu Glu Glu Leu Gly Leu Leu Met Gln Arg Cys Trp 
    770                 775                 780                 


Ala Glu Asp Pro Gln Glu Arg Pro Pro Phe Gln Gln Ile Arg Leu Thr 
785                 790                 795                 800 


Leu Arg Lys Phe Asn Arg Glu Asn Ser Ser Asn Ile Leu Asp Asn Leu 
                805                 810                 815     


Leu Ser Arg Met Glu Gln Tyr Ala Asn Asn Leu Glu Glu Leu Val Glu 
            820                 825                 830         


Glu Arg Thr Gln Ala Tyr Leu Glu Glu Lys Arg Lys Ala Glu Ala Leu 
        835                 840                 845             


Leu Tyr Gln Ile Leu Pro His Ser Val Ala Glu Gln Leu Lys Arg Gly 
    850                 855                 860                 


Glu Thr Val Gln Ala Glu Ala Phe Asp Ser Val Thr Ile Tyr Phe Ser 
865                 870                 875                 880 


Asp Ile Val Gly Phe Thr Ala Leu Ser Ala Glu Ser Thr Pro Met Gln 
                885                 890                 895     


Val Val Thr Leu Leu Asn Asp Leu Tyr Thr Cys Phe Asp Ala Val Ile 
            900                 905                 910         


Asp Asn Phe Asp Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met 
        915                 920                 925             


Val Val Ser Gly Leu Pro Val Arg Asn Gly Arg Leu His Ala Cys Glu 
    930                 935                 940                 


Val Ala Arg Met Ala Leu Ala Leu Leu Asp Ala Val Arg Ser Phe Arg 
945                 950                 955                 960 


Ile Arg His Arg Pro Gln Glu Gln Leu Arg Leu Arg Ile Gly Ile His 
                965                 970                 975     


Thr Gly Pro Val Cys Ala Gly Val Val Gly Leu Lys Met Pro Arg Tyr 
            980                 985                 990         


Cys Leu Phe Gly Asp Thr Val Asn  Thr Ala Ser Arg Met  Glu Ser Asn 
        995                 1000                 1005             


Gly Glu  Ala Leu Lys Ile His  Leu Ser Ser Glu Thr  Lys Ala Val 
    1010                 1015                 1020             


Leu Glu  Glu Phe Gly Gly Phe  Glu Leu Glu Leu Arg  Gly Asp Val 
    1025                 1030                 1035             


Glu Met  Lys Gly Lys Gly Lys  Val Arg Thr Tyr Trp  Leu Leu Gly 
    1040                 1045                 1050             


Glu Arg  Gly Ser Ser Thr Arg  Gly 
    1055                 1060     


<210>  19
<211>  4246
<212>  DNA
<213>  Homo sapiens

<400>  19
ggttccctcc ggatagccgg agacttgggc cggccggacg ccccttctgg cacactccct     60

ggggcaggcg ctcacgcacg ctacaaacac acactcctct ttcctccctc gcgcgccctc    120

tctcatcctt cttcacgaag cgctcactcg caccctttct ctctctctct ctctctctaa    180

cacgcacgca cactcccagt tgttcacact cgggtcctct ccagcccgac gttctcctgg    240

cacccacctg ctccgcggcg ccctgcgcgc ccccctcggt cgcgcccctt gcgctctcgg    300

cccagaccgt cgcagctaca gggggcctcg agccccgggg tgagcgtccc cgtcccgctc    360

ctgctccttc ccatagggac gcgcctgatg cctgggaccg gccgctgagc ccaaggggac    420

cgaggaggcc atggtaggag cgctcgcctg ctgcggtgcc cgctgaggcc atgccggggc    480

cccggcgccc cgctggctcc cgcctgcgcc tgctcctgct cctgctgctg ccgccgctgc    540

tgctgctgct ccggggcagc cacgcgggca acctgacggt agccgtggta ctgccgctgg    600

ccaatacctc gtacccctgg tcgtgggcgc gcgtgggacc cgccgtggag ctggccctgg    660

cccaggtgaa ggcgcgcccc gacttgctgc cgggctggac ggtccgcacg gtgctgggca    720

gcagcgaaaa cgcgctgggc gtctgctccg acaccgcagc gcccctggcc gcggtggacc    780

tcaagtggga gcacaacccc gctgtgttcc tgggccccgg ctgcgtgtac gccgccgccc    840

cagtggggcg cttcaccgcg cactggcggg tcccgctgct gaccgccggc gccccggcgc    900

tgggcttcgg tgtcaaggac gagtatgcgc tgaccacccg cgcggggccc agctacgcca    960

agctggggga cttcgtggcg gcgctgcacc gacggctggg ctgggagcgc caagcgctca   1020

tgctctacgc ctaccggccg ggtgacgaag agcactgctt cttcctcgtg gaggggctgt   1080

tcatgcgggt ccgcgaccgc ctcaatatta cggtggacca cctggagttc gccgaggacg   1140

acctcagcca ctacaccagg ctgctgcgga ccatgccgcg caaaggccga gttatctaca   1200

tctgcagctc ccctgatgcc ttcagaaccc tcatgctcct ggccctggaa gctggcttgt   1260

gtggggagga ctacgttttc ttccacctgg atatctttgg gcaaagcctg caaggtggac   1320

agggccctgc tccccgcagg ccctgggaga gaggggatgg gcaggatgtc agtgcccgcc   1380

aggcctttca ggctgccaaa atcattacat ataaagaccc agataatccc gagtacttgg   1440

aattcctgaa gcagttaaaa cacctggcct atgagcagtt caacttcacc atggaggatg   1500

tcctggtgaa caccatccca gcatccttcc acgacgggct cctgctctat atccaggcag   1560

tgacggagac tctggcacat gggggaactg ttactgatgg ggagaacatc actcagcgga   1620

tgtggaaccg aagctttcaa ggtgtgacag gatacctgaa aattgatagc agtggcgatc   1680

gggaaacaga cttctccctc tgggatatgg atcccgagaa tggtgccttc agggttgtac   1740

tgaactacaa tgggacttcc caagagctgg tggctgtgtc ggggcgcaaa ctgaactggc   1800

ccctggggta ccctcctcct gacatcccca aatgtggctt tgacaacgaa gacccagcat   1860

gcaaccaaga tcacctttcc accctggagg tgctggcttt ggtgggcagc ctctccttgc   1920

tcggcattct gattgtctcc ttcttcatat acaggaagat gcagctggag aaggaactgg   1980

cctcggagct gtggcgggtg cgctgggagg acgttgagcc cagtagcctt gagaggcacc   2040

tgcggagtgc aggcagccgg ctgaccctga gcgggagagg ctccaattac ggctccctgc   2100

taaccacaga gggccagttc caagtctttg ccaagacagc atattataag ggcaacctcg   2160

tggctgtgaa acgtgtgaac cgtaaacgca ttgagctgac acgaaaagtc ctgtttgaac   2220

tgaagcatat gcgggatgtg cagaatgaac acctgaccag gtttgtggga gcctgcaccg   2280

acccccccaa tatctgcatc ctcacagagt actgtccccg tgggagcctg caggacattc   2340

tggagaatga gagcatcacc ctggactgga tgttccggta ctcactcacc aatgacatcg   2400

tcaagggcat gctgtttcta cacaatgggg ctatctgttc ccatgggaac ctcaagtcat   2460

ccaactgcgt ggtagatggg cgctttgtgc tcaagatcac cgactatggg ctggagagct   2520

tcagggacct ggacccagag caaggacaca ccgtttatgc caaaaagctg tggacggccc   2580

ctgagctcct gcgaatggct tcaccccctg tgcggggctc ccaggctggt gacgtataca   2640

gctttgggat catccttcag gagattgccc tgaggagtgg ggtcttccac gtggaaggtt   2700

tggacctgag ccccaaagag atcatcgagc gggtgactcg gggtgagcag ccccccttcc   2760

ggccctccct ggccctgcag agtcacctgg aggagttggg gctgctcatg cagcggtgct   2820

gggctgagga cccacaggag aggccaccat tccagcagat ccgcctgacg ttgcgcaaat   2880

ttaacaggga gaacagcagc aacatcctgg acaacctgct gtcccgcatg gagcagtacg   2940

cgaacaatct ggaggaactg gtggaggagc ggacccaggc atacctggag gagaagcgca   3000

aggctgaggc cctgctctac cagatcctgc ctcactcagt ggctgagcag ctgaagcgtg   3060

gggagacggt gcaggccgaa gcctttgaca gtgttaccat ctacttcagt gacattgtgg   3120

gtttcacagc gctgtcggcg gagagcacgc ccatgcaggt ggtgaccctg ctcaatgacc   3180

tgtacacttg ctttgatgct gtcatagaca actttgatgt gtacaaggtg gagacaattg   3240

gcgatgccta catggtggtg tcagggctcc ctgtgcggaa cgggcggcta cacgcctgcg   3300

aggtagcccg catggccctg gcactgctgg atgctgtgcg ctccttccga atccgccacc   3360

ggccccagga gcagctgcgc ttgcgcattg gcatccacac aggacctgtg tgtgctggag   3420

tggtgggact gaagatgccc cgttactgtc tctttgggga tacagtcaac acagcctcaa   3480

gaatggagtc taatggggaa gccctgaaga tccacttgtc ttctgagacc aaggctgtcc   3540

tggaggagtt tggtggtttc gagctggagc ttcgagggga tgtagaaatg aagggcaaag   3600

gcaaggttcg gacctactgg ctccttgggg agagggggag tagcacccga ggctgacctg   3660

cctcctctcc tatccctcca cacctcccct accctgtgcc agaagcaaca gaggtgccag   3720

gcctcagcct cacccacagc agccccatcg ccaaaggatg gaagtaattt gaatagctca   3780

ggtgtgctta ccccagtgaa gacaccagat aggacctctg agaggggact ggcatggggg   3840

gatctcagag cttacaggct gagccaagcc cacggccatg cacagggaca ctcacacagg   3900

cacacgcacc tgctctccac ctggactcag gccgggctgg gctgtggatt cctgatcccc   3960

tcccctcccc atgctctcct ccctcagcct tgctaccctg tgacttactg ggaggagaaa   4020

gagtcacctg aaggggaaca tgaaaagaga ctaggtgaag agagggcagg ggagcccaca   4080

tctggggctg gcccacaata cctgctcccc cgaccccctc cacccagcag tagacacagt   4140

gcacagggga gaagaggggt ggcgcagaag ggttgggggc ctgtatgcct tgcttctacc   4200

atgagcagag acaattaaaa tctttattcc aaaaaaaaaa aaaaaa                  4246


<210>  20
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Pro Ser Leu Leu Val Leu Thr Phe Ser Pro Cys Val Leu Leu Gly 
1               5                   10                  15      


Trp Ala Leu Leu Ala Gly Gly Thr Gly Gly Gly Gly Val Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Ile Gly Gly Gly Arg Gln Glu Arg Glu Ala Leu 
        35                  40                  45              


Pro Pro Gln Lys Ile Glu Val Leu Val Leu Leu Pro Gln Asp Asp Ser 
    50                  55                  60                  


Tyr Leu Phe Ser Leu Thr Arg Val Arg Pro Ala Ile Glu Tyr Ala Leu 
65                  70                  75                  80  


Arg Ser Val Glu Gly Asn Gly Thr Gly Arg Arg Leu Leu Pro Pro Gly 
                85                  90                  95      


Thr Arg Phe Gln Val Ala Tyr Glu Asp Ser Asp Cys Gly Asn Arg Ala 
            100                 105                 110         


Leu Phe Ser Leu Val Asp Arg Val Ala Ala Ala Arg Gly Ala Lys Pro 
        115                 120                 125             


Asp Leu Ile Leu Gly Pro Val Cys Glu Tyr Ala Ala Ala Pro Val Ala 
    130                 135                 140                 


Arg Leu Ala Ser His Trp Asp Leu Pro Met Leu Ser Ala Gly Ala Leu 
145                 150                 155                 160 


Ala Ala Gly Phe Gln His Lys Asp Ser Glu Tyr Ser His Leu Thr Arg 
                165                 170                 175     


Val Ala Pro Ala Tyr Ala Lys Met Gly Glu Met Met Leu Ala Leu Phe 
            180                 185                 190         


Arg His His His Trp Ser Arg Ala Ala Leu Val Tyr Ser Asp Asp Lys 
        195                 200                 205             


Leu Glu Arg Asn Cys Tyr Phe Thr Leu Glu Gly Val His Glu Val Phe 
    210                 215                 220                 


Gln Glu Glu Gly Leu His Thr Ser Ile Tyr Ser Phe Asp Glu Thr Lys 
225                 230                 235                 240 


Asp Leu Asp Leu Glu Asp Ile Val Arg Asn Ile Gln Ala Ser Glu Arg 
                245                 250                 255     


Val Val Ile Met Cys Ala Ser Ser Asp Thr Ile Arg Ser Ile Met Leu 
            260                 265                 270         


Val Ala His Arg His Gly Met Thr Ser Gly Asp Tyr Ala Phe Phe Asn 
        275                 280                 285             


Ile Glu Leu Phe Asn Ser Ser Ser Tyr Gly Asp Gly Ser Trp Lys Arg 
    290                 295                 300                 


Gly Asp Lys His Asp Phe Glu Ala Lys Gln Ala Tyr Ser Ser Leu Gln 
305                 310                 315                 320 


Thr Val Thr Leu Leu Arg Thr Val Lys Pro Glu Phe Glu Lys Phe Ser 
                325                 330                 335     


Met Glu Val Lys Ser Ser Val Glu Lys Gln Gly Leu Asn Met Glu Asp 
            340                 345                 350         


Tyr Val Asn Met Phe Val Glu Gly Phe His Asp Ala Ile Leu Leu Tyr 
        355                 360                 365             


Val Leu Ala Leu His Glu Val Leu Arg Ala Gly Tyr Ser Lys Lys Asp 
    370                 375                 380                 


Gly Gly Lys Ile Ile Gln Gln Thr Trp Asn Arg Thr Phe Glu Gly Ile 
385                 390                 395                 400 


Ala Gly Gln Val Ser Ile Asp Ala Asn Gly Asp Arg Tyr Gly Asp Phe 
                405                 410                 415     


Ser Val Ile Ala Met Thr Asp Val Glu Ala Gly Thr Gln Glu Val Ile 
            420                 425                 430         


Gly Asp Tyr Phe Gly Lys Glu Gly Arg Phe Glu Met Arg Pro Asn Val 
        435                 440                 445             


Lys Tyr Pro Trp Gly Pro Leu Lys Leu Arg Ile Asp Glu Asn Arg Ile 
    450                 455                 460                 


Val Glu His Thr Asn Ser Ser Pro Cys Lys Ser Ser Gly Gly Leu Glu 
465                 470                 475                 480 


Glu Ser Ala Val Thr Gly Ile Val Val Gly Ala Leu Leu Gly Ala Gly 
                485                 490                 495     


Leu Leu Met Ala Phe Tyr Phe Phe Arg Lys Lys Tyr Arg Ile Thr Ile 
            500                 505                 510         


Glu Arg Arg Thr Gln Gln Glu Glu Ser Asn Leu Gly Lys His Arg Glu 
        515                 520                 525             


Leu Arg Glu Asp Ser Ile Arg Ser His Phe Ser Val Ala 
    530                 535                 540     


<210>  21
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an SiRNA for an NPR-A

<400>  21
tattacggtg gaccacctgt tcaagagaca ggtggtccac cgtaatattt ttt            53


<210>  22
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an SiRNA for an NPR-A

<400>  22
agaattccag aaacgcagct tcaagagagc tgcgtttctg gaattctttt ttt            53


<210>  23
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an SiRNA for an NPR-A

<400>  23
catatggggc ccgggcgctg ctgctgctac cctcgaaatg gtagcagcag cagcgccctt     60

gaattcccat gg                                                         72


<210>  24
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an SiRNA for an NPR-A

<400>  24
catatggggc ccgcggccac gcgagcgacc tctcgaaata ggtcgctcgc gtggccgctt     60

gaattcccat gg                                                         72


<210>  25
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an SiRNA for an NPR-A

<400>  25
catatggggc ccggctcggc cggacttgct gctcgaaatc agcaagtccg gccgagcctt     60

gaattcccat gg                                                         72


<210>  26
<211>  15810
<212>  DNA
<213>  Homo sapiens

<400>  26
ggatcccaaa ccagcacacc tttccctctt cccccgagga gaccaggtag gaggcgaggg     60

aaaaggtggg gcgcaagtgg gccccggttg cttccacaca caccctccgt tcagccgtcc    120

tttccatccc ggcgagggcg caccttcaga gggtcctgtc ctccaaagag gtaggcgtgg    180

ggcggccgag accggggaag atggtccacg gggaagcgcg cgggctgggc ggcggggagg    240

aaggagtcta tgatcctgga ttggctcttc tgtcactgag tctgggaggg gaagcggctg    300

ggagggaggg ttcggagctt ggctcgggtc ctccacggtt ccctccggat agccggagac    360

ttgggccggc cggacgcccc ttctggcaca ctccctgggg caggcgctca cgcacgctac    420

aaacacacac tcctctttcc tccctcgcgc gccctctctc atccttcttc acgaagcgct    480

cactcgcacc ctttctctct ctctctctct ctctaacacg cacgcacact cccagttgtt    540

cacactcggg tcctctccag cccgacgttc tcctggcacc cacctgctcc gcggcgccct    600

gcacgccccc ctcggtcgcg ccccttgcgc tctcggccca gaccgtcgca gctacagggg    660

gcctcgagcc ccggggtgag cgtccccgtc ccgctcctgc tccttcccat agggacgcgc    720

ctgatgcctg ggaccggccg ctgagcccaa ggggaccgag gaggccatgg taggagcgct    780

cgcctgctgc ggtgcccgct gaggccatgc cggggccccg gcgccccgct ggctcccgcc    840

tgcgcctgct cctgctcctg ctgctgccgc cgctgctgct gctgctccgg ggcagccacg    900

cgggcaacct gacggtagcc gtggtactgc cgctggccaa tacctcgtac ccctggtcgt    960

gggcgcgcgt gggacccgcc gtggagctgg ccctggccca ggtgaaggcg cgccccgact   1020

tgctgccggg ctggacggtc cgcacggtgc tgggcagcag cgaaaacgcg ctgggcgtct   1080

gctccgacac cgcagcgccc ctggccgcgg tggacctcaa gtgggagcac aaccccgctg   1140

tgttcctggg ccccggctgc gtgtacgccg ccgccccagt ggggcgcttc accgcgcact   1200

ggcgggtccc gctgctgacc gccggcgccc cggcgctggg cttcggtgtc aaggacgagt   1260

atgcgctgac cacccgcgcg gggcccagct acgccaagct gggggacttc gtggcggcgc   1320

tgcaccgacg gctgggctgg gagcgccaag cgctcatgct ctacgcctac cggccgggtg   1380

acgaagagca ctgcttcttc ctcgtggagg ggctgttcat gcgggtccgc gaccgcctca   1440

atattacggt ggaccacctg gagttcgccg aggacgacct cagccactac accaggctgc   1500

tgcggaccat gccgcgcaaa ggccgaggtg agacgctggc acaccccgtc ccgccgctta   1560

gccgcagggc ctcccctctg acctgccgga ggcatcggga ctttctctct catctggggg   1620

cactcttctt tctcctcgcc gttcttcatt ctactttcag ctccctggcc ctttctacag   1680

ctgagtttct atttccctct cttcttccgc cacccccacc acgtctctat cctctcatct   1740

ccccgacccc cactcattcc ctcccaccct agcacagctc ggttccggtc cctttttccc   1800

tcccacattt tctctcttcc ctatagcctt ctcccttctt tcatcctctc ctctcatggc   1860

gcctcatccc ctctcttctc cccctccctc tccctcctct ctccctcctg gccccatcct   1920

tctccacctt cagctccact atccccctct ccctacccgt tccttcctcc cttccgcctc   1980

ccccttcctc ctcccgccca ccgccccgca cccgcccgtt ccacccttcg actttctcct   2040

gctgtggcct aggctgagcc gggagttacc acttaactct cactgggtct ctcctgcacc   2100

ctatctctaa acttcctccc ttgggtgccc cagctttcct actcctgtct ctcccgcagt   2160

acctaggctt ctctctctga ctctccgtct ttctccagtt atctacatct gcagctcccc   2220

tgatgccttc agaaccctca tgctcctggc cctggaagct ggcttgtgtg gggaggacta   2280

cgttttcttc cacctggata tctttgggca aagcctgcaa ggtggacagg gccctgctcc   2340

ccgcaggccc tgggagagag gggatgggca ggatgtcagt gcccgccagg cctttcaggt   2400

gagtacctag gtttgaagcc caggctgtct cagcttgtgg cacatcattt ctgggcactg   2460

tgtccctcag catctgaaag aattccagaa aagaggtttt tgtctgtttg tttctttatg   2520

cactcctggt aactcacaga acagaaaaga ggttggtgat gctcactggg aattaggcaa   2580

tgaagggcag gggactgccc aggggcgctt cgccaccagc aggctaaaaa gataagaaaa   2640

tgggcttgag gcgggaggag gataaagtcc cacagcctgg acaggacttg gagaaggcat   2700

cccattggat cccctgcttt ggaatgggca tcacttcatg cagggcatag ggtccagttt   2760

gaccttgagc taagcagaga cgcagctctg ggaggtgggc tcccaactgt tggggcccca   2820

cagtactagg gaatagtcag ctcccaactc tctgctctcc actgacccct ttctcaggct   2880

gccaaaatca ttacatataa agacccagat aatcccgagt acttggaatt cctgaagcag   2940

ttaaaacacc tggcctatga gcagttcaac ttcaccatgg aggatggcct ggtaagaagg   3000

ggtcccggga ccctccagcg tggacctcca gcccccactc catgaccctc tgccagcctc   3060

catccttccc tattcccagt tctccccttc cttccctccc ttcccattgt tccatgtttc   3120

tcgtgatgat ggaggaggac actggcaagt tcagcctctg aaactcaggt catcatcagt   3180

aatatggaga cgatacatcc tgccctgtct acctagtagg attcaggaag tgatgctaat   3240

ccaaaggcat cgtttaaata gtaaaatctc cctgtgatat aggggtgtta ttttctccca   3300

tcctcttcca aaatcccagt gcctcttgtt cccttcccca cagctcccac ctccatgccc   3360

ttcatatgcc caccccagcc gacctctgtt tgcccctaca ggtgaacacc atcccagcat   3420

ccttccacga cgggctcctg ctctatatcc aggcagtgac ggagactctg gcacatgggg   3480

gaactgttac tgatggggag aacatcactc agcggatgtg gaaccgaagc tttcaaggtc   3540

agggcctgga ggtggctgga atgggctgcc ttgggggatg aatcccaggt gcccagtgtc   3600

aagccatgag aagcctattg tcctgcagca gttacctatg cacaccagcc ttttcctcca   3660

cagctttttt caggcccatc cctcagaagt cctacaaagt gtccaatctc aatcatccct   3720

gctgggcact gagttctttt acctttcttt ttcttttttc tttttttttt gagatggagt   3780

ctcgctctgt ccccaagact ggagtgtggt ggtgcaatct cggctcactt caacctccgc   3840

ctcccaggtt caagcaattc tcctgcctca gcctcctgag tagctgggat tacaggtgcc   3900

ctccaccaac acttggctaa ttttttgtat tttttttagt agagacaggg tttcaccacg   3960

ttggtcaggc tggtcttgaa ctcctgacgt caggtgatct gcccgcctca gcctcccaaa   4020

gtgctgggat tacaagcatg agccacagtg cccggccgtt ttaccattta ctatcattct   4080

gtatacatgt atgtttggaa ggcaaggcaa aaaagattag aggatgaaga gatgaagtgg   4140

ggcacccctg aacttctatt ctctcaaaca tagtcatctt cccccatgtc ctcaggtgtg   4200

acaggatacc tgaaaattga tagcagtggc gatcgggaaa cagacttctc cctctgggat   4260

atggatcccg agaatggtgc cttcagggta agtttgtgca cccagaagac agtgccaatt   4320

ccaaatgaca tctcaccctc ctacttcccc cccacagccc tgccagggca cctgtttatc   4380

ctgtagccat tccaccatgc ctggacactt acaagagccc tggataaaac agacccagct   4440

ccagtctggg gaagccacca gaatgatagg gactcacagg catcacactt ggggagcccc   4500

atgcctgagg agggagcaca agcctgccct cggggagctc cgaagggagg caggcaggac   4560

cgcctcccag cagagacagg gctgtgaaag atgcacatta cacagctctg caagcgagca   4620

gggacaggaa ggcgctgagg ccaatggcca caagggacag gtcatccaga gaaggcctcc   4680

tggaagacgg gcacatggac tgggcctgcg aatgtaggct aaggtgaaca ttaccttctc   4740

ctgttttcta ccaagaaaat aagtagagaa aaatcaatgc ttggttggta cttcaaccaa   4800

gattataaac tccctgagtg tagagatcgg gttctaaatg gagttttctt tataaacccc   4860

ttgatagttt tcaggtgttt ccacttgagt actatgtgtg tggtatgagg tcctgtgtcc   4920

agttgcagtg gggacttggt aagcaggtga caacccagat atatatgtag gctctagaag   4980

cagagctggg gtaggtggga ggtgagactg ctgcactcac agcatgcctt ccccgcaggc   5040

cctggcctag ccaccactcc tgctctccct taggttgtac tgaactacaa tgggacttcc   5100

caagagctgg tggctgtgtc ggggcgcaaa ctgaactggc ccctggggta ccctcctcct   5160

gacatcccca aatgtggctt tgacaacgaa gacccagcat gcaaccaagg tgactgcccc   5220

ttgccttcca ggcctccatc ccagagatgc tgcatccttc ccctaagcac agtcgagtag   5280

gtgctcctgt cccatgctga gggctttctg gagaatgact cctgcctttt tcttcccttc   5340

atccatcatc ccagttcact gatggactat tagaaagttc ttcctcctgc tgtctaaccc   5400

aaatctctct tgctgcaata tggactctct cctgcagatc acctttccac cctggaggtg   5460

ctggctttgg tgggcagcct ctccttgctc ggcattctga ttgtctcctt cttcatatac   5520

aggtgagctg tgatgtgggg ggttgagtga ggctggggga cccggagaac caagagcaga   5580

ggaggcggtg gggacccaga gggaagaggg caggggtgaa ggggcagcag gggaaaacca   5640

agggagatga ggaagaaagg aggcttaaaa gccagaggag aaagaaagag aagggaatgg   5700

cagggcgagg ggaggagaca aggataggaa tggccaagga gagtcagaaa gatccaagaa   5760

gcagagaagt tgatgggtga catcataggg gcgtggactg gttttccttg ctactcttgc   5820

aggccagata ggaagcaact ttctgaacct ttgcaatcat gcccatgtta gctgaggagg   5880

gtgagccctg gtgtgtgcca ggtgcccaac ctagaatgga gaagggagct gaatgagcct   5940

tgttcctgcc gtccagtgga ggctaaaatg aagtacagga ggagttaatg atatacaaaa   6000

gcaaggaggg aggggagaaa aatcactgct ggttgagcat ataatgtgtg ccaggcactt   6060

ccacgtacac tatttctttc tttctttttt tttttttttt tttttttttg agacggagtc   6120

tcgctctgtt gccagactgg agtgcagtgg catgatctag gctcactgca acctccgcct   6180

cccagtttca agcaattctc ctgcctcagc ctcccatgta gctgggacta caggcacatg   6240

ccaccacgct cagctaattt ttgtattttt agtagagaca gggtttcacc atgttggcca   6300

ggatggtctc gatctcttga cctcatgatc cacccacctt ggcctcccaa agtgctggga   6360

ttacaggcat gagccactgt gcctggcctc atgttcacta tttcttttca ttcttataat   6420

agttaagaat gaaatagata ttgcggcctc attcccaagt aaggacattg aggtgattcc   6480

cccaaggtcc ccagtaaggc agaatttccc ccagccatcc tgattctcag tccagaggat   6540

agaattcccc ctccatctct gagtgcatgg tgtggtccca cggctctgag gaggggctgc   6600

tgagcaccct gccctgggtc agcggctcag ccacaggctc agatgcagcc ttcgtatccc   6660

aggaagatgc agctggagaa ggaactggcc tcggagctgt ggcgggtgcg ctgggaggac   6720

gttgagccca gtagccttga gaggcacctg cggagtgcag gcagccggct gaccctgagc   6780

ggggtaagaa cgctggtgtt tgtgttgggg ggcaataaag gagaggtggg tacaaggggc   6840

agtgcctgag ggataggtaa gggagcagga ttctagtccc agctctgctt tcacttgctg   6900

tgtgaccttg agcgactcat agtccctctc cgagactgtc tcagatgatg attacagcag   6960

cagagcctcc ctcacagggc tcttttaaag gtcagaggag atagtacctg tgaaaacact   7020

ttaaaaaaaa aaaaagtaaa tgaggaggaa attttatgat gtggaacata aagcagggtg   7080

ggccaggcac agtggctcac atctgcaatc ccagcacttt gggagaccga ggcaggagga   7140

ttgcttgtgc ctgggagttc aagaccagcc tgggcaacag agcaagacat cgtctctaca   7200

aagaatacaa agattagcag ggcatggtgg cgcatacctg tagtcccagc tactctggag   7260

gctgaggtga aaggatcatc tgagcccagg agtctgaggc ggcagtgacc taggatagca   7320

ccactgcact ccagcctgga tgacacaatg atactacatc tcaaaaaaaa acccaacaac   7380

aaaaaggaag ggtgacacaa agataaggca ggataaggca gggaaataaa gaccagagca   7440

caagcaatca ggatgcagac tgggcccacc ggctgaccat tcctcctgct ctccctcctt   7500

tcagagaggc tccaattacg gctccctgct aaccacagag ggccagttcc aagtctttgc   7560

caagacagca tattataagg tgggcctggg gaaagatcac tgggccttgg gactggggca   7620

ggagtgtact ctgatggagg actggtgggg ggttctgagg gaaggagtaa gctggtgggg   7680

agcagcagat gggggccctg ggggtgggct attgggaaca agtgagggtc ctgagggcag   7740

ggatgggctg tcgggagcag ctggaattcc caggacatgg gaccatgctc ttcacagtga   7800

cagtctccat tccatgccca gggcaacctc gtggctgtga aacgtgtgaa ccgtaaacgc   7860

attgagctga cacgaaaagt cctgtttgaa ctgaagcatg taatgtgggg agtgaggcag   7920

tggcatggag aaggggccct cggggacgca agggagactg gccaacagaa ctagttatgg   7980

agggacctca gggtacccca agaaaggggc agggactgga gccctggatg accttcatct   8040

tgtggtggag tgggggtatc ctaagtagga gaagagacca ctgagataac ctggaggaat   8100

cttgaggggc catatgtgat gtccctgggg gagagagggc ttaggatgcc agagggagta   8160

ggagcagatt ctggggaggg tgggctaaag gacatgggtg ggaatcacca gggaagatct   8220

tagtgatggt tgcagaaagt gaataaggag ttaagaagag tgagggtccc tgaagctagt   8280

gagcagcttg gtgaggagcg aggtctctgt caagctcctg atgctggtcc cacttgcaga   8340

tgcgggatgt gcagaatgaa cacctgacca ggtttgtggg agcctgcacc gaccccccca   8400

atatctgcat cctcacagag tactgtcccc gtgggagcct gcaggtgagg gggacaaggg   8460

gtgtcaagaa acctgggttc tagccctggc tctgcccctg actggccata agaccccagg   8520

catgcctcgc cctctttctg acctttctgg ccccatctgt aaaaatggga gttggggaag   8580

ggcagtggca ctagagtcaa tccaaagttt tgtcctgttc taccagttca catcagtagg   8640

accctgcacc ctcctccaac tcccaggggg atctgcaggg gattggtctt gactcttatt   8700

gccccagcag gacattctgg agaatgagag catcaccctg gactggatgt tccggtactc   8760

actcaccaat gacatcgtca aggtatgccc ctaagcacct attggatgtg tagagcaggg   8820

gccaggcatg cttctcctgg ccacgggtgt aggtcccact cctggccaat acctctgccc   8880

actcacattt ccagggcatg ctgtttctac acaatggggc tatctgttcc catgggaacc   8940

tcaagtcatc caactgcgtg gtagatgggc gctttgtgct caagatcacc gactatgggc   9000

tggagagctt cagggacctg gacccagagc aaggacacac cgtttatgcc agtgagcctt   9060

gactcttgaa cctaacacct gcccccagca ccacccagta gggagactga tgcaaggcct   9120

ctgatgggct tgggcatgct tgtcctgact ccagcctcaa ttcattcacc catgaaaaag   9180

ggaaggccag acgaagtggt ttctaaggcc tcctctagct ctaacactct gtgatgcatc   9240

cagatcagtt tcggccacac ccttgtttcc ccctcacccc ttagctttgg gctccctcac   9300

tcggtgacta ccgacctctg acccacagaa aagctgtgga cggcccctga gctcctgcga   9360

atggcttcac cccctgtgcg gggctcccag gctggtgacg tatacagctt tgggatcatc   9420

cttcaggaga ttgccctgag gagtggggtc ttccacgtgg aaggtttgga cctgagcccc   9480

aaaggtgaga ggagcacacc ttccttaaac ccagccacag tctcaacgaa ccccagcccc   9540

agggagaggg tcccctggca gcaccaccac accttccttc tgtaatgggg ttcagtcacc   9600

accctttgac ccattgctgc cagtgaccag tcccccgccc ccatgccttg gtcttggact   9660

tcccctgcca tctcagctgg ttgccccagt ctctcactag gcccttggcc agccccaccc   9720

ctcagctcct ctacccccca atacagagat catcgagcgg gtgactcggg gtgagcagcc   9780

ccccttccgg ccctccctgg ccctgcagag tcacctggag gagttggggc tgctcatgca   9840

gcggtgctgg gctgaggacc cacaggagag gccaccattc cagcagatcc gcctgacgtt   9900

gcgcaaattt aacaggtccc tggtgtttgt catggatccc ccaggccctt cctccacagc   9960

caccatttac ctaatgcttc tggctctggc ttatcccagc agtggcagag ggagaccact  10020

cacctcctcc ctgtacatag tcagctccag ctcagcacag cctcatgacc ctcttcgcaa  10080

gtacagcatg actcagctgt ccccacagtc ccctgccatt catgcccctt ccctccacca  10140

tcgacacccc acacccttcc tgcccactcg ccttgctggc ctctagactt ctcagcagtg  10200

tgtaggatag atgggcctcc cgcctcctgc cctgtaggct cttggccctc cacgggagct  10260

cctgccccac cccttgattt cccttcccca gcgtgcccac caggcccagt tcctccagac  10320

acacccttct gtggacatca ctttgtccgc aattgaccct tgtcattctc cacctccttt  10380

acctccttct aactcactgg gttcaacaaa gatgaacaaa atgtccatat gtctgaagct  10440

tcatacttga ccttggggtc tcagaaaaga attgaacttt cttccttctg ttttcccctg  10500

ctccccggta tcctgctatg ccctcaaccc tgagcgtctc tagagacctc actgcagtct  10560

ggagggggaa gtgcctaggg gcgggcgctc acgtaggctg tgctgctcct ctcttaccac  10620

ccccaccgcc accctctgcc cccagggaga acagcagcaa catcctggac aacctgctgt  10680

cccgcatgga gcagtacgcg aacaatctgg aggaactggt ggaggagcgg acccaggcat  10740

acctggagga gaagcgcaag gctgaggccc tgctctacca gatcctgcct cagtgagtgc  10800

ctgagtctgg ggaccccccc caacacaaag cccctgtccc gacccccaac tctgatcctg  10860

cacctgccct gaccccttag ctcagtggct gagcagctga agcgtgggga gacggtgcag  10920

gccgaagcct ttgacagtgt taccatctac ttcagtgaca ttgtgggttt cacagcgctg  10980

tcggcggaga gcacacccat gcaggtaggc cagggttcag ccacaggtgc caggcaagct  11040

cagcatctgg atcccaccag acctgccttc tggttctgct ttacccacct gaccccaggt  11100

ggggtcccct acttcctgtc tctcttagct tctcttccct tccaggtggt gaccctgctc  11160

aatgacctgt acacttgctt tgatgctgtc atagacaact ttgatgtgta caaggtgagg  11220

gtgggagtgg ggatgggaag ggacagacag acatggacaa ggtcagaaaa agatgagggg  11280

taggcagaat gatgtggagt cttaagagag gagatcgggg acacgggcag agacagtgac  11340

acagggagac ccgggaacag gcagagaacc catgtgggat gggggatgag caaagacaga  11400

tgagggtaca gaatgacaga cgctgcaccc ggtgtgacgg tgtggccggc cgcacagttg  11460

cagccgtcaa gtcctgcacc ccctcgccac tcccacaggt ggagacaatt ggcgatgcct  11520

acatggtggt gtcagggctc cctgtgcgga acgggcggct acacgcctgc gaggtagccc  11580

gcatggccct ggcactgctg gatgctgtgc gctccttccg aatccgccac cggccccagg  11640

agcagctgcg cttgcgcatt ggcatccaca caggtaaggc cactgaaggt gcaggcgggc  11700

atccagaggc caaggctttg caagggaaac ttgtcccctg gcccagcccc tcgccctttc  11760

atctctctct ctctctctct ctctctctct ctctctctct gtctctctct ctctctctct  11820

ctctctctct ctcacacaca cacacacaca cacacacaga gctgggacct cagatcctgc  11880

ctcctgcctg tcttggattg tccacctacc tcccttaaca cccctccctc cctcactcgc  11940

tgatgggctc tgctccttcc cttgctcctc ccaggacctg tgtgtgctgg agtggtggga  12000

ctgaagatgc cccgttactg tctctttggg gatacagtca acacagcctc aagaatggag  12060

tctaatgggg aaggtacagt gccccctcct agagggaatg gggagggcag ggtggctgag  12120

ggaaatgcca tcctggggca gcctgtgcct gcacagcccg tttcagctcc tagccctttc  12180

gcctcccaag ttccccttct cataatatta agagttcaac ctgggctcat caacttgact  12240

gtaaccagag actcaggttc ctgctgcccc tcttgtcaaa cgatgtaaaa gtatttccgg  12300

gccagtgctg gagagttccc agcaggaatc tgattttaag accctctgtg ggccgggcgt  12360

ggtgactcac acctgtgatc ccagcacttt gggaagctga ggcaggcgga tcacctgagg  12420

tcgggggttt cgagaccagc ctgaccaaca tgatgaaatc ccgtctctac taaaaataca  12480

aaaaactagc caggtgtgat ggcaggctcc tgtaatccca gctacttggg aggcttgagg  12540

cagaagaatt gcttgaaccc gggaggcaga ggttgcgatg agccaagatt acaccacgca  12600

ccccagcttg ggcaataaga gttaaactct gtctcaaaaa aaaaaaaaaa aaaaaaaaaa  12660

agggccctct gctccacctt tgatgtggta aagatggctt cagagccagc ataagtgagg  12720

ctgtgaatct cagctccaca gctggctgtg tgtcagtttg ctatacctct ctgagccatg  12780

gttttcctca tctgtaaaaa gagggaaaaa atctatctca caggaattat gtgagaaacc  12840

cattaaaaat gtctaccaca taattgtcat ttaacttttc caagccttag cggattatct  12900

gtaaaatgat gtctatctca ggattgcaag aagcctagca caaaccctgg tacccagcag  12960

gcacctaata aattcttact cctacccgcc ccttgctctt gcctcctgtt tatcttctat  13020

ccttctgctg tattcgacac aattcaatgc agtaaacatt tattgagtga ctactgagtg  13080

ccaggccctg ggatagtaac atggcccaga tccagagtta gctgagaaat tcatgtggac  13140

cccatctaaa ccttatggtg aaagaaaggc tgcttgggag ccagtcctgg gagcccagag  13200

ggatctagtt cggcaaatat tccctgggca ctatttgggg gctgcagagt cagcccttgt  13260

tgagggtcca gtcctcaagg agcacattcc cagaaatgtt cacattctgg cgctggggtg  13320

ctgtaatccc agcactttgg gaggccgagg tgggcagatc acttgaggcc aggagtggag  13380

actagcctgg ccaacatggt gacctcctgt ctctactaaa aatacaaaaa attagctggg  13440

cgtggtggca cgtgcccgta atcccagcta ctcaggaggc ttgagacatg aaaatcactt  13500

gaacccagga ggtggatgtt gcagtgagcc gagactgcac ccctgggcaa cagagcgaga  13560

ctctgtctca aaaaaaaaaa agagagaaag aaagaaaaga aaagaaagaa actgttaaac  13620

acaacaaggc cactgtgatt gatgcaaacc ccagaagtag ggacatgagt tcagacagtg  13680

gtcaaagaga gggtgtggca atattgggcc ccactccatc actgacctcc tcagccactt  13740

gggcagatca ccctgggcct cagttcctcg gccacaaaat gagggtatag catgaaatca  13800

tgaaagcaac aatttacata gtgcttccta ggtagcacat tccgtttgaa tactttatgg  13860

atgttaaatt taatcctcac aacaaggttt tgagatgggt actgacacta tcagcatttt  13920

acagattagg aaaatgaagc agagagaatt tattttacat acctaagcaa gtatccaagc  13980

tgaggttcat actgaggcag tgcaggatcc aaagtgccag ctcctaacca ccatgctgtg  14040

tagagccggg tgacactcca gagagtgctg tccaacagga tgttccatag tcatgaaaat  14100

gttctgtatt ctgtgctgtc caatacagta gcctctaggc acatatggct acttatcact  14160

ggaaatgtga cgggtgcaac tgaggccctg attttttttt tttttttgga gacagagttt  14220

cgctctgtcg cccagcctgg atggagtgca gtggtgcaat ctcggctcac tgcaacctcc  14280

gcctcccagg ttcaagcgat tctcctgcct cagcctccca agtagctgga attacaggtg  14340

agtgccacca cacacagcta atttttgtat ttttagtaga gacggggttt cgccatattg  14400

gccaggatgg tctcgaactc ctggcctcaa gtgatcctcc tgcctcagcc tcccaaagtg  14460

ctgggattac aggtgtgagc cacagcaccc agcctgaatt tttaactgta tttagtttaa  14520

attaatttaa gttgaaacag gcacatgtga ttagtggcta ctgtattgga ttacacagct  14580

ccagagttct aaatgagagg ctaatgtggt cacgcactac attcaggggg tggggcccct  14640

ctgagctaga gggcttcctg gcccaaaaga gggagagagg gtacctgtcc acctgtccac  14700

ccccacagtc cctggtctct tttgcctcta ctttcctgct ctcctctctc acattgctca  14760

ccttcccttc tcccctgtcc tacccagccc tgaagatcca cttgtcttct gagaccaagg  14820

ctgtcctgga ggagtttggt ggtttcgagc tggagcttcg aggggatgta gaaatgaagg  14880

tagagcgaga agcctctgcc ctccccacct tttggggtcc tagagggagt tacccttctc  14940

aagcagccga tgccactccc atccctaagg ctctcatctg actggggaaa gggcatgtgc  15000

cactccccag cccatcctct tttttccctc cagggcaaag gcaaggttcg gacctactgg  15060

ctccttgggg agagggggag tagcacccga ggctgacctg cctcctctcc tatccctcca  15120

cacctcccct accctgtgcc agaagcaaca gaggtgccag gcctcagcct cacccacagc  15180

agccccatcg ccaaaggatg gaagtaattt gaatagctca ggtgtgctga ccccagtgaa  15240

gacaccagat aggacctctg agaggggact ggcatggggg gatctcagag cttacaggct  15300

gagccaagcc cacggccatg cacagggaca ctcacacagg cacacgcacc tgctctccac  15360

ctggactcag gccgggctgg gctgtggatt cctgatcccc tcccctcccc atgctctcct  15420

ccctcagcct tgctaccctg tgacttactg ggaggagaaa gagtcacctg aaggggaaca  15480

tgaaaagaga ctaggtgaag agagggcagg ggagcccaca tctggggctg gcccacaata  15540

cctgctcccc cgaccccctc cacccagcag tagacacagt gcacagggga gaagaggggt  15600

ggcgcagaag ggttgggggc ctgtatgcct tgcttctacc atgagcagag acaattaaaa  15660

tctttattcc agtgacagtg tctcttcttg agggagagag ggttgccaga aaacagtcag  15720

ttctccactc tctacttcaa ataagactca cttcttgttc tacaagggtc tagaaggaaa  15780

agtaaaaaaa aaagactctc gattcttaac                                   15810


<210>  27
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an NPRA specific primer

<400>  27
gcaaaggccg agttatctac at                                              22


<210>  28
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an NPRA specific primer

<400>  28
aacgtagtct cccacacaa                                                  19


