                         SEQUENCE LISTING

<110>  Medarex, Inc.
       TERRETT, Jonathan A.
       CARDARELLI, Josephine M.
       RAO-NAIK, Chetana
       CHEN, Bingliang
       KING, David J.
 
<120>  Anti-B7H4 Monoclonal Antibody-Drug Conjugate and Methods of Use

<130>  MEDX-0199PC1

<140>  WO 00/000,000
<141>  2008-11-26

<150>  US 60/991693
<151>  2007-11-30

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Tyr 
            20                  25                  30          


Phe Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ala Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Ser Ser Trp Ser Asn Trp Ala Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  2


<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Gly Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Thr Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  3
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val Ser Arg Asn 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Gly Ser Gly Arg Thr Asp Cys Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Asp Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  4
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ala Leu Tyr Gly Ser Gly Ser Ser Asp Phe Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Ala Val Ser Ser 
        115                 120                 125     


<210>  5
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  5

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Lys Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Leu Arg Tyr Phe Glu Asn Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  6
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Ile Val Leu Thr Gln Phe Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Val Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  7
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Met Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  8
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  9
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Arg Thr Phe Gly Gln 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys 
            100             


<210>  10
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  11
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Tyr Phe Trp Thr 
1               5   


<210>  12
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  12

Ser Asn Tyr Met Asn Trp 
1               5       


<210>  13
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Asn Tyr Met Asn 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Tyr Ala Met His 
1               5   


<210>  15
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Tyr Tyr Trp Ser 
1               5   


<210>  16
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Ile Asn His Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  17
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  17

Val Ile Tyr Gly Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  18
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  18

Val Ile Tyr Gly Ser Gly Arg Thr Asp Cys Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  19
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  19

Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  20

Lys Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  21
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  21

Leu Ser Ser Trp Ser Asn Trp Ala Phe Glu Tyr 
1               5                   10      


<210>  22
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  22

Asp Thr Tyr Ala Met Asp Val 
1               5           


<210>  23
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Gly Asp Tyr Gly Met Asp Val 
1               5               


<210>  24
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  24

Leu Tyr Gly Ser Gly Ser Ser Asp Phe Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  25
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  25

Glu Leu Arg Tyr Phe Glu Asn Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  


<210>  26
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  26

Arg Ala Ser Gln Ser Val Ser Ser Thr Tyr Leu Ala 
1               5                   10          


<210>  27
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  27

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  28
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  28

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  29
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  29

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  30
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  30

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  31
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  31

Gly Ala Ser Arg Arg Ala Thr 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  32

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  33
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  33

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  34
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  34

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  35
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  35

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Gln Tyr Gly Ser Ser Pro Leu Thr 
1               5                   


<210>  37
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  37

Gln Gln Tyr Gly Ser Ser Pro Met Tyr Thr 
1               5                   10  


<210>  38
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  38

Gln Gln Tyr Gly Ser Ser Pro Leu Tyr Thr 
1               5                   10  


<210>  39
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  39

Gln Gln Arg Arg Thr 
1               5   


<210>  40
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  40

Gln Gln Tyr Gly Ser Ser Pro Arg Thr 
1               5                   


<210>  41
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  41
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt gattacttct ggacctggat ccgccagccc      120

ccagggaagg gcctggagtg gattggggaa atcaatcata gtggaaccac caactacaac      180

ccgtccctca agagtcgagt caccatttca gcagacacgt ccaagaacca gttctccctg      240

aggctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag actcagcagc      300

tggtcgaact gggcctttga gtactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  42
<211>  345
<212>  DNA
<213>  Homo sapiens

<400>  42
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatggca gtggtagaac atattacgca      180

gactccgtga agggccgagt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agatacctac      300

gctatggacg tctggggcca agggaccacg gtcaccgtct cctct                      345


<210>  43
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  43
gaggtgcagt tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt catcgtcagt agaaactaca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatggca gtggtaggac agactgcgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agatggggac      300

tacggtatgg acgtctgggg ccaagggacc acggtcaccg tctcctca                   348


<210>  44
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  44
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgtag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtac aaaagccctc      300

tatggttcgg ggagttctga cttctactac tacggtatgg acgtctgggg ccaagggacc      360

acggtcgccg tctcctca                                                    378


<210>  45
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  45
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc      120

ccagggaagg ggctggagtg gattgggaaa atcaatcata gcggaagtac caactacaac      180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aaactaaact ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag agaattacga      300

tattttgaaa actactacta cggtatggac gtctggggcc aagggaccac ggtcaccgtc      360

tcctca                                                                 366


<210>  46
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  46
gaaattgtgt tgacgcagtt tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcacctact tagcctggta ccagcagaaa      120

cctggccagg ctcccagggt cctcatctat ggtgcatcca gaagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgct cactttcggc      300

ggagggacca aggtggagat caaa                                             324


<210>  47
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  47
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacccat gtacactttt      300

ggccagggga ccaagctgga gatcaaa                                          327


<210>  48
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  48
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctct gtacactttt      300

ggccagggga ccaagctgga gatcaaa                                          327


<210>  49
<211>  309
<212>  DNA
<213>  Homo sapiens

<400>  49
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtaggacgt tcggccaagg gaccaaggtg      300

gaaatcaaa                                                              309


<210>  50
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  50
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctcg gacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210>  51
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  51

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  52
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  53
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp 
            


<210>  54
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  54

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


<210>  55
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  55

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp 
                85                  90                  


<210>  56
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
        275                 280         


<210>  57
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  57

Ala Leu Ala Leu 
1               


<210>  58
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is beta-alanine

<400>  58

Xaa Leu Ala Leu 
1               


<210>  59
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  59

Gly Phe Leu Gly 
1               


<210>  60
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  60

Leu Leu Gly Leu 
1               


<210>  61
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  61

Pro Arg Phe Lys 
1               


<210>  62
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  62

Thr Arg Leu Arg 
1               


<210>  63
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  63

Ser Lys Gly Arg 
1               


<210>  64
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  64

Pro Asn Asp Lys 
1               


<210>  65
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  65

Pro Val Gly Leu Ile Gly 
1               5       


<210>  66
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  66

Gly Pro Leu Gly Val 
1               5   


<210>  67
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  67

Gly Pro Leu Gly Ile Ala Gly Gln 
1               5               


<210>  68
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  68

Pro Leu Gly Leu 
1               


<210>  69
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  69

Gly Pro Leu Gly Met Leu Ser Gln 
1               5               


<210>  70
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  70

Gly Pro Leu Gly Leu Trp Ala Gln 
1               5               


<210>  71
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  71

Leu Ser Ser Trp Ser Asn Trp Ala Phe Glu Tyr Trp Gly Gln Gly Thr 
1               5                   10                  15      


Leu Val Thr Val Ser Ser 
            20          


<210>  72
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  72

Glu Leu Arg Tyr Phe Glu Asn Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  


<210>  73
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  73

Tyr Gly Ser Gly Ser 
1               5   


<210>  74
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  74

Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
1               5                   10                  15      


Thr Val Ser Ser 
            20  


<210>  75
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  75

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10      


<210>  76
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  76

Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


