                         SEQUENCE LISTING

<110>  Levine, Martin
 
<120>  MUTANTS OF LYSINE DECARBOXYLASE, VACCINES FOR PERIODONTITIS, AND 
       METHODS OF USE

<130>  5835.103wo

<150>  61/005,693
<151>  2007-12-07

<160>  6     

<170>  PatentIn version 3.3

<210>  1
<211>  2130
<212>  DNA
<213>  Eikenella corrodens

<400>  1
atgaagaaca tcttattagg ctgtggtcat aaggaacttg gtgactatct gaagagcttg     60

attgaaactt tggaaaaggg tggtcacacc atccgaatag cccatgaccc gcaagaaatc    120

ctgacgttcc tgaaacatga cgccagaata ggctcagtgc tttgtacact ggatattttc    180

aaccgagaat tagacgaaca aattattgca ctcaacgatg agctacccgt attcattctg    240

aagcccaccg actgcgacaa acccgtggac ttcggcgctg taggcgacca tgccaccttc    300

atcgattgcc atctgttcag caacgaagac gttgttgata aaattgaaaa agcaatctgt    360

cactatatcg acaatatcac cccgcccttc actaaagccc tgtttgacta cgttgataaa    420

aacaaataca cattctgtac tccgggtcac atgagcggta ccgctttctt gaaatctccc    480

gtaggtagcc tgttctacga cttctacggt gaaaacacat tcaaatcaga tatttcagtt    540

tctatgggcg aattgggctc tctgctcgac cactccggcc cgcacaaaga ggccgaagaa    600

tacatcgccg aaaccttcaa tgccgaccac agctacatcg taaccaacgg tacttccacc    660

gccaacaaaa tcgtgggtat gtactccgtt ccggccggca gcaccgtact gatcgaccgt    720

aactgccaca aatcattaac ccacctgttg atgatgagcg acattactcc ggtgtatctg    780

aaaccgaccc gtaacgccta cggtatcttg ggtggtattc cgcaaaaaga attcaccaaa    840

gaagttatta ccgaaaaact taccaaagtt ccgggcgcca cttggccggt acatgccgtg    900

attaccaact ccacttatga cggcctgttc tacaacaccg acaagatcaa agacaccctg    960

gatgtgaaat ccatccactt cgactctgct tgggttccct acaccaactt cagcccgatc   1020

tacaacggca aaaccggtat gggcggtaag caggttaaag acaaggtaat ctttgaaacc   1080

cactctaccc acaaactgct ggccgcattc tcacaggctt ccatgattca cgttaagggt   1140

aacctgaaca ccgccacctt cggcgaagcc tacatgatgc acacctccac ttctccgttc   1200

taccccatgg tagcctctac tgaagtggca gcagccatga tgcgcggcaa ctccggtaaa   1260

cgcctgatgc aggattcact ggaacgcgcc gttaaattcc gtaaggaaat caagaaacac   1320

aaagcccatg ccgactcatg gtatttcgat gtatggcaac ctgaaaatgt tgacaacatc   1380

gaatgctggg aattgcatca gaccgacaaa tggcacggct tcaaagacat cgacgcccag   1440

cacatgtacc tcgacccgat taaggtaact ctgcttaccc cgggcttgga taaaaacggc   1500

gagctggaaa aaaccggtat ccccgccaac ctcgtttcca aattcttgga agaccgcggc   1560

atcatcgtgg agaaaaccgg cccctacaac atcctcgtgc tcttcagcat cggcgtggac   1620

gacaccaaag ccctcagcct gctgcacgca ttgaacgagt tcaaatccct gtacgatgcc   1680

aacgccaccg tagaagaagt attgccgcgc gtattcaacg aatcgccctc tttctaccaa   1740

gaaatgcgga ttcaagaatt ggcacaaggc atccacagcc tgatctgcaa acacaacctg   1800

cctgaactga tgttcagcgc attcgaagtg ttgccgacca tggtgatgaa cccgcacaaa   1860

gccttccagc ttgagctgaa aggtcagatt gaagactgct acttggaaga catggtaggc   1920

aagatcaacg ccaacatgat tctgccctat cctcccggcg taccgttggt aatgcctggt   1980

gaaatgatca ccgaagaaag caagcccatc ttggaattcc tgatgatgct gtgcgaaatc   2040

ggcgcccact tccccggctt cgaaaccgac atccacggtg cttaccgtca agaagacggc   2100

cgctataaag ttaagattgt taaagcttaa                                    2130


<210>  2
<211>  709
<212>  PRT
<213>  Eikenella corrodens

<400>  2

Met Lys Asn Ile Leu Leu Gly Cys Gly His Lys Glu Leu Gly Asp Tyr 
1               5                   10                  15      


Leu Lys Ser Leu Ile Glu Thr Leu Glu Lys Gly Gly His Thr Ile Arg 
            20                  25                  30          


Ile Ala His Asp Pro Gln Glu Ile Leu Thr Phe Leu Lys His Asp Ala 
        35                  40                  45              


Arg Ile Gly Ser Val Leu Cys Thr Leu Asp Ile Phe Asn Arg Glu Leu 
    50                  55                  60                  


Asp Glu Gln Ile Ile Ala Leu Asn Asp Glu Leu Pro Val Phe Ile Leu 
65                  70                  75                  80  


Lys Pro Thr Asp Cys Asp Lys Pro Val Asp Phe Gly Ala Val Gly Asp 
                85                  90                  95      


His Ala Thr Phe Ile Asp Cys His Leu Phe Ser Asn Glu Asp Val Val 
            100                 105                 110         


Asp Lys Ile Glu Lys Ala Ile Cys His Tyr Ile Asp Asn Ile Thr Pro 
        115                 120                 125             


Pro Phe Thr Lys Ala Leu Phe Asp Tyr Val Asp Lys Asn Lys Tyr Thr 
    130                 135                 140                 


Phe Cys Thr Pro Gly His Met Ser Gly Thr Ala Phe Leu Lys Ser Pro 
145                 150                 155                 160 


Val Gly Ser Leu Phe Tyr Asp Phe Tyr Gly Glu Asn Thr Phe Lys Ser 
                165                 170                 175     


Asp Ile Ser Val Ser Met Gly Glu Leu Gly Ser Leu Leu Asp His Ser 
            180                 185                 190         


Gly Pro His Lys Glu Ala Glu Glu Tyr Ile Ala Glu Thr Phe Asn Ala 
        195                 200                 205             


Asp His Ser Tyr Ile Val Thr Asn Gly Thr Ser Thr Ala Asn Lys Ile 
    210                 215                 220                 


Val Gly Met Tyr Ser Val Pro Ala Gly Ser Thr Val Leu Ile Asp Arg 
225                 230                 235                 240 


Asn Cys His Lys Ser Leu Thr His Leu Leu Met Met Ser Asp Ile Thr 
                245                 250                 255     


Pro Val Tyr Leu Lys Pro Thr Arg Asn Ala Tyr Gly Ile Leu Gly Gly 
            260                 265                 270         


Ile Pro Gln Lys Glu Phe Thr Lys Glu Val Ile Thr Glu Lys Leu Thr 
        275                 280                 285             


Lys Val Pro Gly Ala Thr Trp Pro Val His Ala Val Ile Thr Asn Ser 
    290                 295                 300                 


Thr Tyr Asp Gly Leu Phe Tyr Asn Thr Asp Lys Ile Lys Asp Thr Leu 
305                 310                 315                 320 


Asp Val Lys Ser Ile His Phe Asp Ser Ala Trp Val Pro Tyr Thr Asn 
                325                 330                 335     


Phe Ser Pro Ile Tyr Asn Gly Lys Thr Gly Met Gly Gly Lys Gln Val 
            340                 345                 350         


Lys Asp Lys Val Ile Phe Glu Thr His Ser Thr His Lys Leu Leu Ala 
        355                 360                 365             


Ala Phe Ser Gln Ala Ser Met Ile His Val Lys Gly Asn Leu Asn Thr 
    370                 375                 380                 


Ala Thr Phe Gly Glu Ala Tyr Met Met His Thr Ser Thr Ser Pro Phe 
385                 390                 395                 400 


Tyr Pro Met Val Ala Ser Thr Glu Val Ala Ala Ala Met Met Arg Gly 
                405                 410                 415     


Asn Ser Gly Lys Arg Leu Met Gln Asp Ser Leu Glu Arg Ala Val Lys 
            420                 425                 430         


Phe Arg Lys Glu Ile Lys Lys His Lys Ala His Ala Asp Ser Trp Tyr 
        435                 440                 445             


Phe Asp Val Trp Gln Pro Glu Asn Val Asp Asn Ile Glu Cys Trp Glu 
    450                 455                 460                 


Leu His Gln Thr Asp Lys Trp His Gly Phe Lys Asp Ile Asp Ala Gln 
465                 470                 475                 480 


His Met Tyr Leu Asp Pro Ile Lys Val Thr Leu Leu Thr Pro Gly Leu 
                485                 490                 495     


Asp Lys Asn Gly Glu Leu Glu Lys Thr Gly Ile Pro Ala Asn Leu Val 
            500                 505                 510         


Ser Lys Phe Leu Glu Asp Arg Gly Ile Ile Val Glu Lys Thr Gly Pro 
        515                 520                 525             


Tyr Asn Ile Leu Val Leu Phe Ser Ile Gly Val Asp Asp Thr Lys Ala 
    530                 535                 540                 


Leu Ser Leu Leu His Ala Leu Asn Glu Phe Lys Ser Leu Tyr Asp Ala 
545                 550                 555                 560 


Asn Ala Thr Val Glu Glu Val Leu Pro Arg Val Phe Asn Glu Ser Pro 
                565                 570                 575     


Ser Phe Tyr Gln Glu Met Arg Ile Gln Glu Leu Ala Gln Gly Ile His 
            580                 585                 590         


Ser Leu Ile Cys Lys His Asn Leu Pro Glu Leu Met Phe Ser Ala Phe 
        595                 600                 605             


Glu Val Leu Pro Thr Met Val Met Asn Pro His Lys Ala Phe Gln Leu 
    610                 615                 620                 


Glu Leu Lys Gly Gln Ile Glu Asp Cys Tyr Leu Glu Asp Met Val Gly 
625                 630                 635                 640 


Lys Ile Asn Ala Asn Met Ile Leu Pro Tyr Pro Pro Gly Val Pro Leu 
                645                 650                 655     


Val Met Pro Gly Glu Met Ile Thr Glu Glu Ser Lys Pro Ile Leu Glu 
            660                 665                 670         


Phe Leu Met Met Leu Cys Glu Ile Gly Ala His Phe Pro Gly Phe Glu 
        675                 680                 685             


Thr Asp Ile His Gly Ala Tyr Arg Gln Glu Asp Gly Arg Tyr Lys Val 
    690                 695                 700                 


Lys Ile Val Lys Ala 
705                 


<210>  3
<211>  2130
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Artificially synthesized.

<400>  3
atgaaaaaca ttctgctggg ttgcggtcat aaagaactgg gcgactatct gaaatcactg     60

atcgaaaccc tggaaaaagg cggccatacg attcgcattg cacacgatcc gcaagaaatt    120

ctgaccttcc tgaaacacga tgcacgcatt ggttctgtcc tgtgtaccct ggatattttt    180

aatcgtgaac tggacgaaca gattatcgcg ctgaatgacg aactgccggt tttcattctg    240

aaaccgacgg attgcgataa accggtggat ttcggtgcgg tgggcgatca tgccacgttt    300

atcgattgtc atctgttttc caacgaagac gtcgtcgata aaatcgaaaa agccatctgc    360

cactacatcg ataacattac gccgccgttc accaaagcac tgtttgacta cgtggataaa    420

aataaatata ccttttgcac cccgggccac atgagcggta ccgcgtttct gaaatcaccg    480

gtcggttctc tgttctacga cttctacggc gaaaacacct ttaaatcaga catttctgtg    540

agcatgggcg aactgggcag cctgctggac cacagcggcc cgcacaaaga agcagaagaa    600

tatatcgcag aaacgtttaa cgcggatcat agctacattg tgaccaacgg tacgagcacc    660

gccaataaaa ttgtgggcat gtatagcgtg ccggccggca gcaccgtcct gatcgaccgc    720

aactgtcata aaagcctgac gcatctgctg atgatgtcag atattacccc ggtgtacctg    780

aaaccgacgc gtaatgcgta tggcattctg ggtggcattc cgcagaaaga atttaccaaa    840

gaagtgatta cggaaaaact gaccaaagtg ccgggcgcga cctggccggt gcatgcagtg    900

attaccaaca gcacctacga cggtctgttt tacaacaccg ataaaatcaa agacaccctg    960

gatgttaaat ctattcattt cgactctgcg tgggtcccgt ataccaactt ttctccgatc   1020

tataatggta aaaccggtat gggcggcaaa caggttaaag acaaagtcat tttcgaaacc   1080

cactcaaccc acaaactgct ggcagcattc tctcaggcat caatgattca cgtgaaaggt   1140

aacctgaaca cggcgacctt cggtgaagcc tatatgatgc ataccagcac gagcccgttc   1200

tatccgatgg tcgcgagcac ggaagttgct gctgcgatga tgcgtggtaa cagtggtaaa   1260

cgcctgatgc aggactcgct ggaacgcgcg gttaaatttc gtaaagaaat caaaaaacat   1320

aaagcccatg cagattcatg gtactttgac gtgtggcagc cggaaaatgt cgataatatt   1380

gaatgctggg aactgcatca aacggataaa tggcatggtt tcaaagatat tgatgcgcag   1440

cacatgtacc tggacccgat caaagtgacc ctgctgaccc cgggtctgga taaaaatggc   1500

gaactggaaa aaaccggtat tccggctaac ctggtgtcta aatttctgga agatcgtggc   1560

attattgtgg aaaaaacggg tccgtataac attctggtgc tgtttagcat tggcgtggat   1620

gataccaaag cactgtcact gctgcatgct ctgaatgaat tcaaaagcct gtatgatgcg   1680

aacgcaaccg ttgaagaagt gctgccgcgt gtgttcaacg aaagcccgag tttttatcag   1740

gaaatgcgta ttcaggaact ggcacagggc atccacagcc tgatttgcaa acataacctg   1800

ccggaactga tgttcagtgc gtttgaagtg ctgccgacga tggttatgaa tccgcacaaa   1860

gcctttcagc tggaactgaa aggtcagatc gaagattgct atctggaaga tatggttggt   1920

aaaattaacg caaatatgat tctgccgtat ccgccgggcg tcccgctggt gatgccgggt   1980

gaaatgatca cggaagaatc caaaccgatt ctggaatttc tgatgatgct gtgcgaaatc   2040

ggcgcgcatt ttccgggctt tgaaaccgat attcacggtg cataccgtca ggaagatggc   2100

cgctacaaag tcaaaattgt gaaagcctaa                                    2130


<210>  4
<211>  709
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificially synthesized.

<400>  4

Met Lys Asn Ile Leu Leu Gly Cys Gly His Lys Glu Leu Gly Asp Tyr 
1               5                   10                  15      


Leu Lys Ser Leu Ile Glu Thr Leu Glu Lys Gly Gly His Thr Ile Arg 
            20                  25                  30          


Ile Ala His Asp Pro Gln Glu Ile Leu Thr Phe Leu Lys His Asp Ala 
        35                  40                  45              


Arg Ile Gly Ser Val Leu Cys Thr Leu Asp Ile Phe Asn Arg Glu Leu 
    50                  55                  60                  


Asp Glu Gln Ile Ile Ala Leu Asn Asp Glu Leu Pro Val Phe Ile Leu 
65                  70                  75                  80  


Lys Pro Thr Asp Cys Asp Lys Pro Val Asp Phe Gly Ala Val Gly Asp 
                85                  90                  95      


His Ala Thr Phe Ile Asp Cys His Leu Phe Ser Asn Glu Asp Val Val 
            100                 105                 110         


Asp Lys Ile Glu Lys Ala Ile Cys His Tyr Ile Asp Asn Ile Thr Pro 
        115                 120                 125             


Pro Phe Thr Lys Ala Leu Phe Asp Tyr Val Asp Lys Asn Lys Tyr Thr 
    130                 135                 140                 


Phe Cys Thr Pro Gly His Met Ser Gly Thr Ala Phe Leu Lys Ser Pro 
145                 150                 155                 160 


Val Gly Ser Leu Phe Tyr Asp Phe Tyr Gly Glu Asn Thr Phe Lys Ser 
                165                 170                 175     


Asp Ile Ser Val Ser Met Gly Glu Leu Gly Ser Leu Leu Asp His Ser 
            180                 185                 190         


Gly Pro His Lys Glu Ala Glu Glu Tyr Ile Ala Glu Thr Phe Asn Ala 
        195                 200                 205             


Asp His Ser Tyr Ile Val Thr Asn Gly Thr Ser Thr Ala Asn Lys Ile 
    210                 215                 220                 


Val Gly Met Tyr Ser Val Pro Ala Gly Ser Thr Val Leu Ile Asp Arg 
225                 230                 235                 240 


Asn Cys His Lys Ser Leu Thr His Leu Leu Met Met Ser Asp Ile Thr 
                245                 250                 255     


Pro Val Tyr Leu Lys Pro Thr Arg Asn Ala Tyr Gly Ile Leu Gly Gly 
            260                 265                 270         


Ile Pro Gln Lys Glu Phe Thr Lys Glu Val Ile Thr Glu Lys Leu Thr 
        275                 280                 285             


Lys Val Pro Gly Ala Thr Trp Pro Val His Ala Val Ile Thr Asn Ser 
    290                 295                 300                 


Thr Tyr Asp Gly Leu Phe Tyr Asn Thr Asp Lys Ile Lys Asp Thr Leu 
305                 310                 315                 320 


Asp Val Lys Ser Ile His Phe Asp Ser Ala Trp Val Pro Tyr Thr Asn 
                325                 330                 335     


Phe Ser Pro Ile Tyr Asn Gly Lys Thr Gly Met Gly Gly Lys Gln Val 
            340                 345                 350         


Lys Asp Lys Val Ile Phe Glu Thr His Ser Thr His Lys Leu Leu Ala 
        355                 360                 365             


Ala Phe Ser Gln Ala Ser Met Ile His Val Lys Gly Asn Leu Asn Thr 
    370                 375                 380                 


Ala Thr Phe Gly Glu Ala Tyr Met Met His Thr Ser Thr Ser Pro Phe 
385                 390                 395                 400 


Tyr Pro Met Val Ala Ser Thr Glu Val Ala Ala Ala Met Met Arg Gly 
                405                 410                 415     


Asn Ser Gly Lys Arg Leu Met Gln Asp Ser Leu Glu Arg Ala Val Lys 
            420                 425                 430         


Phe Arg Lys Glu Ile Lys Lys His Lys Ala His Ala Asp Ser Trp Tyr 
        435                 440                 445             


Phe Asp Val Trp Gln Pro Glu Asn Val Asp Asn Ile Glu Cys Trp Glu 
    450                 455                 460                 


Leu His Gln Thr Asp Lys Trp His Gly Phe Lys Asp Ile Asp Ala Gln 
465                 470                 475                 480 


His Met Tyr Leu Asp Pro Ile Lys Val Thr Leu Leu Thr Pro Gly Leu 
                485                 490                 495     


Asp Lys Asn Gly Glu Leu Glu Lys Thr Gly Ile Pro Ala Asn Leu Val 
            500                 505                 510         


Ser Lys Phe Leu Glu Asp Arg Gly Ile Ile Val Glu Lys Thr Gly Pro 
        515                 520                 525             


Tyr Asn Ile Leu Val Leu Phe Ser Ile Gly Val Asp Asp Thr Lys Ala 
    530                 535                 540                 


Leu Ser Leu Leu His Ala Leu Asn Glu Phe Lys Ser Leu Tyr Asp Ala 
545                 550                 555                 560 


Asn Ala Thr Val Glu Glu Val Leu Pro Arg Val Phe Asn Glu Ser Pro 
                565                 570                 575     


Ser Phe Tyr Gln Glu Met Arg Ile Gln Glu Leu Ala Gln Gly Ile His 
            580                 585                 590         


Ser Leu Ile Cys Lys His Asn Leu Pro Glu Leu Met Phe Ser Ala Phe 
        595                 600                 605             


Glu Val Leu Pro Thr Met Val Met Asn Pro His Lys Ala Phe Gln Leu 
    610                 615                 620                 


Glu Leu Lys Gly Gln Ile Glu Asp Cys Tyr Leu Glu Asp Met Val Gly 
625                 630                 635                 640 


Lys Ile Asn Ala Asn Met Ile Leu Pro Tyr Pro Pro Gly Val Pro Leu 
                645                 650                 655     


Val Met Pro Gly Glu Met Ile Thr Glu Glu Ser Lys Pro Ile Leu Glu 
            660                 665                 670         


Phe Leu Met Met Leu Cys Glu Ile Gly Ala His Phe Pro Gly Phe Glu 
        675                 680                 685             


Thr Asp Ile His Gly Ala Tyr Arg Gln Glu Asp Gly Arg Tyr Lys Val 
    690                 695                 700                 


Lys Ile Val Lys Ala 
705                 


<210>  5
<211>  2130
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Artificially synthesized.

<400>  5
atgaaaaaca ttctgctggg ttgcggtcat aaagaactgg gcgactatct gaaatcactg     60

atcgaaaccc tggaaaaagg cggccatacg attcgcattg cacacgatcc gcaagaaatt    120

ctgaccttcc tgaaacacga tgcacgcatt ggttctgtcc tgtgtaccct ggatattttt    180

aatcgtgaac tggacgaaca gattatcgcg ctgaatgacg aactgccggt tttcattctg    240

aaaccgacgg attgcgataa accggtggat ttcggtgcgg tgggcgatca tgccacgttt    300

atcgattgtc atctgttttc caacgaagac gtcgtcgata aaatcgaaaa agccatctgc    360

cactacatcg ataacattac gccgccgttc accaaagcac tgtttgacta cgtggataaa    420

aataaatata ccttttgcac cccgggccac atgagcggta ccgcgtttct gaaatcaccg    480

gtcggttctc tgttctacga cttctacggc gaaaacacct ttaaatcaga catttctgtg    540

agcatgggcg aactgggcag cctgctggac cacagcggcc cgcacaaaga agcagaagaa    600

tatatcgcag aaacgtttaa cgcggatcat agctacattg tgaccaacgg tacgagcacc    660

gccaataaaa ttgtgggcat gtatagcgtg ccggccggca gcaccgtcct gatcgaccgc    720

aactgtcata aaagcctgac gcatctgctg atgatgtcag atattacccc ggtgtacctg    780

aaaccgacgc gtaatgcgta tggcattctg ggtggcattc cgcagaaaga atttaccaaa    840

gaagtgatta cggaaaaact gaccaaagtg ccgggcgcga cctggccggt gcatgcagtg    900

attaccaaca gcacctacga cggtctgttt tacaacaccg ataaaatcaa agacaccctg    960

gatgttaaat ctattcattt cgactctgcg tgggtcccgt ataccaactt ttctccgatc   1020

tataatggta aaaccggtat gggcggcaaa caggttaaag acaaagtcat tttcgaaacc   1080

cactcaaccc acgcactgct ggcagcattc tctcaggcat caatgattca cgtgaaaggt   1140

aacctgaaca cggcgacctt cggtgaagcc tatatgatgc ataccagcac gagcccgttc   1200

tatccgatgg tcgcgagcac ggaagttgct gctgcgatga tgcgtggtaa cagtggtaaa   1260

cgcctgatgc aggactcgct ggaacgcgcg gttaaatttc gtaaagaaat caaaaaacat   1320

aaagcccatg cagattcatg gtactttgac gtgtggcagc cggaaaatgt cgataatatt   1380

gaatgctggg aactgcatca aacggataaa tggcatggtt tcaaagatat tgatgcgcag   1440

cacatgtacc tggacccgat caaagtgacc ctgctgaccc cgggtctgga taaaaatggc   1500

gaactggaaa aaaccggtat tccggctaac ctggtgtcta aatttctgga agatcgtggc   1560

attattgtgg aaaaaacggg tccgtataac attctggtgc tgtttagcat tggcgtggat   1620

gataccaaag cactgtcact gctgcatgct ctgaatgaat tcaaaagcct gtatgatgcg   1680

aacgcaaccg ttgaagaagt gctgccgcgt gtgttcaacg aaagcccgag tttttatcag   1740

gaaatgcgta ttcaggaact ggcacagggc atccacagcc tgatttgcaa acataacctg   1800

ccggaactga tgttcagtgc gtttgaagtg ctgccgacga tggttatgaa tccgcacaaa   1860

gcctttcagc tggaactgaa aggtcagatc gaagattgct atctggaaga tatggttggt   1920

aaaattaacg caaatatgat tctgccgtat ccgccgggcg tcccgctggt gatgccgggt   1980

gaaatgatca cggaagaatc caaaccgatt ctggaatttc tgatgatgct gtgcgaaatc   2040

ggcgcgcatt ttccgggctt tgaaaccgat attcacggtg cataccgtca ggaagatggc   2100

cgctacaaag tcaaaattgt gaaagcctaa                                    2130


<210>  6
<211>  709
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificially synthesized.

<400>  6

Met Lys Asn Ile Leu Leu Gly Cys Gly His Lys Glu Leu Gly Asp Tyr 
1               5                   10                  15      


Leu Lys Ser Leu Ile Glu Thr Leu Glu Lys Gly Gly His Thr Ile Arg 
            20                  25                  30          


Ile Ala His Asp Pro Gln Glu Ile Leu Thr Phe Leu Lys His Asp Ala 
        35                  40                  45              


Arg Ile Gly Ser Val Leu Cys Thr Leu Asp Ile Phe Asn Arg Glu Leu 
    50                  55                  60                  


Asp Glu Gln Ile Ile Ala Leu Asn Asp Glu Leu Pro Val Phe Ile Leu 
65                  70                  75                  80  


Lys Pro Thr Asp Cys Asp Lys Pro Val Asp Phe Gly Ala Val Gly Asp 
                85                  90                  95      


His Ala Thr Phe Ile Asp Cys His Leu Phe Ser Asn Glu Asp Val Val 
            100                 105                 110         


Asp Lys Ile Glu Lys Ala Ile Cys His Tyr Ile Asp Asn Ile Thr Pro 
        115                 120                 125             


Pro Phe Thr Lys Ala Leu Phe Asp Tyr Val Asp Lys Asn Lys Tyr Thr 
    130                 135                 140                 


Phe Cys Thr Pro Gly His Met Ser Gly Thr Ala Phe Leu Lys Ser Pro 
145                 150                 155                 160 


Val Gly Ser Leu Phe Tyr Asp Phe Tyr Gly Glu Asn Thr Phe Lys Ser 
                165                 170                 175     


Asp Ile Ser Val Ser Met Gly Glu Leu Gly Ser Leu Leu Asp His Ser 
            180                 185                 190         


Gly Pro His Lys Glu Ala Glu Glu Tyr Ile Ala Glu Thr Phe Asn Ala 
        195                 200                 205             


Asp His Ser Tyr Ile Val Thr Asn Gly Thr Ser Thr Ala Asn Lys Ile 
    210                 215                 220                 


Val Gly Met Tyr Ser Val Pro Ala Gly Ser Thr Val Leu Ile Asp Arg 
225                 230                 235                 240 


Asn Cys His Lys Ser Leu Thr His Leu Leu Met Met Ser Asp Ile Thr 
                245                 250                 255     


Pro Val Tyr Leu Lys Pro Thr Arg Asn Ala Tyr Gly Ile Leu Gly Gly 
            260                 265                 270         


Ile Pro Gln Lys Glu Phe Thr Lys Glu Val Ile Thr Glu Lys Leu Thr 
        275                 280                 285             


Lys Val Pro Gly Ala Thr Trp Pro Val His Ala Val Ile Thr Asn Ser 
    290                 295                 300                 


Thr Tyr Asp Gly Leu Phe Tyr Asn Thr Asp Lys Ile Lys Asp Thr Leu 
305                 310                 315                 320 


Asp Val Lys Ser Ile His Phe Asp Ser Ala Trp Val Pro Tyr Thr Asn 
                325                 330                 335     


Phe Ser Pro Ile Tyr Asn Gly Lys Thr Gly Met Gly Gly Lys Gln Val 
            340                 345                 350         


Lys Asp Lys Val Ile Phe Glu Thr His Ser Thr His Ala Leu Leu Ala 
        355                 360                 365             


Ala Phe Ser Gln Ala Ser Met Ile His Val Lys Gly Asn Leu Asn Thr 
    370                 375                 380                 


Ala Thr Phe Gly Glu Ala Tyr Met Met His Thr Ser Thr Ser Pro Phe 
385                 390                 395                 400 


Tyr Pro Met Val Ala Ser Thr Glu Val Ala Ala Ala Met Met Arg Gly 
                405                 410                 415     


Asn Ser Gly Lys Arg Leu Met Gln Asp Ser Leu Glu Arg Ala Val Lys 
            420                 425                 430         


Phe Arg Lys Glu Ile Lys Lys His Lys Ala His Ala Asp Ser Trp Tyr 
        435                 440                 445             


Phe Asp Val Trp Gln Pro Glu Asn Val Asp Asn Ile Glu Cys Trp Glu 
    450                 455                 460                 


Leu His Gln Thr Asp Lys Trp His Gly Phe Lys Asp Ile Asp Ala Gln 
465                 470                 475                 480 


His Met Tyr Leu Asp Pro Ile Lys Val Thr Leu Leu Thr Pro Gly Leu 
                485                 490                 495     


Asp Lys Asn Gly Glu Leu Glu Lys Thr Gly Ile Pro Ala Asn Leu Val 
            500                 505                 510         


Ser Lys Phe Leu Glu Asp Arg Gly Ile Ile Val Glu Lys Thr Gly Pro 
        515                 520                 525             


Tyr Asn Ile Leu Val Leu Phe Ser Ile Gly Val Asp Asp Thr Lys Ala 
    530                 535                 540                 


Leu Ser Leu Leu His Ala Leu Asn Glu Phe Lys Ser Leu Tyr Asp Ala 
545                 550                 555                 560 


Asn Ala Thr Val Glu Glu Val Leu Pro Arg Val Phe Asn Glu Ser Pro 
                565                 570                 575     


Ser Phe Tyr Gln Glu Met Arg Ile Gln Glu Leu Ala Gln Gly Ile His 
            580                 585                 590         


Ser Leu Ile Cys Lys His Asn Leu Pro Glu Leu Met Phe Ser Ala Phe 
        595                 600                 605             


Glu Val Leu Pro Thr Met Val Met Asn Pro His Lys Ala Phe Gln Leu 
    610                 615                 620                 


Glu Leu Lys Gly Gln Ile Glu Asp Cys Tyr Leu Glu Asp Met Val Gly 
625                 630                 635                 640 


Lys Ile Asn Ala Asn Met Ile Leu Pro Tyr Pro Pro Gly Val Pro Leu 
                645                 650                 655     


Val Met Pro Gly Glu Met Ile Thr Glu Glu Ser Lys Pro Ile Leu Glu 
            660                 665                 670         


Phe Leu Met Met Leu Cys Glu Ile Gly Ala His Phe Pro Gly Phe Glu 
        675                 680                 685             


Thr Asp Ile His Gly Ala Tyr Arg Gln Glu Asp Gly Arg Tyr Lys Val 
    690                 695                 700                 


Lys Ile Val Lys Ala 
705                 


