                               SEQUENCE LISTING

<110> WYETH
 
<120> HIGH RESOLUTION STRUCTURES OF ACIDIC MAMMALIAN CHITINASES 
      AND USES THEREOF

<130> W2025-7029WO

<140>
<141>

<150> 61/007,826
<151> 2007-12-13

<160> 12     

<170> PatentIn version 3.5

<210> 1
<211> 1251
<212> DNA
<213> Homo sapiens

<400> 1
atggccaagc ttattctcct cacaggtctt gtccttatac tgaatttgca gctcggctct     60

gcctaccagc tgacatgcta cttcaccaac tgggcccagt accggccagg cctggggcgc    120

ttcatgcctg acgacatcaa cccctgcctc tgtacccacc tgatctacgc ctttgctggg    180

atgcagaaca acgagatcac caccatcgaa tggaatgatg tgactctcta ccaagctttc    240

aatggcctga aaaataagaa cagccagctg aaaactctcc tggccattgg aggctggaac    300

ttcgggactg cccctttcac tgccatggtt tctactcctg agaaccgcca gactttcatc    360

acctcagtca tcaaattcct gcgccagtat gagtttgacg ggctggactt tgactgggag    420

taccctggct ctcgtgggag ccctcctcag gacaagcatc tcttcactgt cctggtgcag    480

gaaatgcgtg aagcttttga gcaggaggcc aagcagatca acaagcccag gctgatggtc    540

actgctgcag tagctgctgg catctccaat atccagtctg gctatgagat cccccaactg    600

tcacagtacc tggactacat ccatgtcatg acctacgacc tccatggctc ctgggagggc    660

tacactggag agaacagccc cctctacaaa tacccgactg acaccggcag caacgcctac    720

ctcaatgtgg attatgtcat gaactactgg aaggacaatg gagcaccagc tgagaagctc    780

atcgttggat tccctaccta tggacacaac ttcatcctga gcaacccctc caacactgga    840

attggtgccc ccacctctgg tgctggtcct gctgggccct atgccaagga gtctgggatc    900

tgggcttact acgagatctg taccttcctg aaaaatggag ccactcaggg atgggatgcc    960

cctcaggaag tgccttatgc ctatcagggc aatgtatggg ttggctatga caacgtcaag   1020

agcttcgata ttaaggctca atggcttaag cacaacaaat tcggaggcgc catggtctgg   1080

gccattgatc tggatgactt cactggcact ttctgcaacc agggcaagtt tcccctaatc   1140

tccaccctga agaaggccct cggcttgcag agtgcaagtt gcacggctcc agctcagccc   1200

attgagccaa taactgctgc tcccggctcc catcaccatc accatcacta g            1251


<210> 2
<211> 395
<212> PRT
<213> Homo sapiens

<400> 2
Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala Gln Tyr Arg Pro Gly 
1               5                   10                  15      


Leu Gly Arg Phe Met Pro Asp Asp Ile Asn Pro Cys Leu Cys Thr His 
            20                  25                  30          


Leu Ile Tyr Ala Phe Ala Gly Met Gln Asn Asn Glu Ile Thr Thr Ile 
        35                  40                  45              


Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe Asn Gly Leu Lys Asn 
    50                  55                  60                  


Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile Gly Gly Trp Asn Phe 
65                  70                  75                  80  


Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln 
                85                  90                  95      


Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe Asp 
            100                 105                 110         


Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly Ser Pro Pro 
        115                 120                 125             


Gln Asp Lys His Leu Phe Thr Val Leu Val Gln Glu Met Arg Glu Ala 
    130                 135                 140                 


Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro Arg Leu Met Val Thr 
145                 150                 155                 160 


Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln Ser Gly Tyr Glu Ile 
                165                 170                 175     


Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His Val Met Thr Tyr Asp 
            180                 185                 190         


Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 
        195                 200                 205             


Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr Leu Asn Val Asp Tyr 
    210                 215                 220                 


Val Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu Lys Leu Ile 
225                 230                 235                 240 


Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile Leu Ser Asn Pro Ser 
                245                 250                 255     


Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala Gly Pro Ala Gly Pro 
            260                 265                 270         


Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu Ile Cys Thr Phe 
        275                 280                 285             


Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala Pro Gln Glu Val Pro 
    290                 295                 300                 


Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr Asp Asn Val Lys Ser 
305                 310                 315                 320 


Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala 
                325                 330                 335     


Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe Cys Asn 
            340                 345                 350         


Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys Ala Leu Gly Leu 
        355                 360                 365             


Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro Ile Glu Pro Ile Thr 
    370                 375                 380                 


Ala Ala Pro Gly Ser His His His His His His 
385                 390                 395 


<210> 3
<211> 1431
<212> DNA
<213> Homo sapiens

<400> 3
atgacaaagc ttattctcct cacaggtctt gtccttatac tgaatttgca gctcggctct     60

gcctaccagc tgacatgcta cttcaccaac tgggcccagt accggccagg cctggggcgc    120

ttcatgcctg acaacatcga cccctgcctc tgtacccacc tgatctacgc ctttgctggg    180

aggcagaaca acgagatcac caccatcgaa tggaatgatg tgactctcta ccaagctttc    240

aatggcctga aaaataagaa cagccagctg aaaactctcc tggccattgg aggctggaac    300

ttcgggactg cccctttcac tgccatggtt tctactcctg agaaccgcca gactttcatc    360

acctcagtca tcaaattcct gcgccagtat gagtttgacg ggctggactt tgactgggag    420

taccctggct ctcgtgggag ccctcctcag gacaagcatc tcttcactgt cctggtgcag    480

gaaatgcgtg aagcttttga gcaggaggcc aagcagatca acaagcccag gctgatggtc    540

actgctgcag tagctgctgg catctccaat atccagtctg gctatgagat cccccaactg    600

tcacagtacc tggactacat ccatgtcatg acctacgacc tccatggctc ctgggagggc    660

tacactggag agaacagccc cctctacaaa tacccgactg acaccggcag caacgcctac    720

ctcaatgtgg attatgtcat gaactactgg aaggacaatg gagcaccagc tgagaagctc    780

atcgttggat tccctaccta tggacacaac ttcatcctga gcaacccctc caacactgga    840

attggtgccc ccacctctgg tgctggtcct gctgggccct atgccaagga gtctgggatc    900

tgggcttact acgagatctg taccttcctg aaaaatggag ccactcaggg atgggatgcc    960

cctcaggaag tgccttatgc ctatcagggc aatgtgtggg ttggctatga caacatcaag   1020

agcttcgata ttaaggctca atggcttaag cacaacaaat ttggaggcgc catggtctgg   1080

gccattgatc tggatgactt cactggcact ttctgcaacc agggcaagtt tcccctaatc   1140

tccaccctga agaaggccct cggcctgcag agtgcaagtt gcacggctcc agctcagccc   1200

attgagccaa taactgctgc tcccagtggc agcgggaacg ggagcgggag tagcagctct   1260

ggaggcagct cgggaggcag tggattctgt gctgtcagag ccaacggcct ctaccccgtg   1320

gcaaataaca gaaatgcctt ctggcactgc gtgaatggag tcacgtacca gcagaactgc   1380

caggccgggc ttgtcttcga caccagctgt gattgctgca actgggcata a            1431


<210> 4
<211> 476
<212> PRT
<213> Homo sapiens

<400> 4
Met Thr Lys Leu Ile Leu Leu Thr Gly Leu Val Leu Ile Leu Asn Leu 
1               5                   10                  15      


Gln Leu Gly Ser Ala Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala 
            20                  25                  30          


Gln Tyr Arg Pro Gly Leu Gly Arg Phe Met Pro Asp Asn Ile Asp Pro 
        35                  40                  45              


Cys Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Arg Gln Asn Asn 
    50                  55                  60                  


Glu Ile Thr Thr Ile Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe 
65                  70                  75                  80  


Asn Gly Leu Lys Asn Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr 
            100                 105                 110         


Pro Glu Asn Arg Gln Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg 
        115                 120                 125             


Gln Tyr Glu Phe Asp Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser 
    130                 135                 140                 


Arg Gly Ser Pro Pro Gln Asp Lys His Leu Phe Thr Val Leu Val Gln 
145                 150                 155                 160 


Glu Met Arg Glu Ala Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro 
                165                 170                 175     


Arg Leu Met Val Thr Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln 
            180                 185                 190         


Ser Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His 
        195                 200                 205             


Val Met Thr Tyr Asp Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu 
    210                 215                 220                 


Asn Ser Pro Leu Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr 
225                 230                 235                 240 


Leu Asn Val Asp Tyr Val Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro 
                245                 250                 255     


Ala Glu Lys Leu Ile Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile 
            260                 265                 270         


Leu Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala 
        275                 280                 285             


Gly Pro Ala Gly Pro Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr 
    290                 295                 300                 


Glu Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala 
305                 310                 315                 320 


Pro Gln Glu Val Pro Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr 
                325                 330                 335     


Asp Asn Ile Lys Ser Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn 
            340                 345                 350         


Lys Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr 
        355                 360                 365             


Gly Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys 
    370                 375                 380                 


Lys Ala Leu Gly Leu Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro 
385                 390                 395                 400 


Ile Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser Gly Asn Gly Ser Gly 
                405                 410                 415     


Ser Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Phe Cys Ala Val 
            420                 425                 430         


Arg Ala Asn Gly Leu Tyr Pro Val Ala Asn Asn Arg Asn Ala Phe Trp 
        435                 440                 445             


His Cys Val Asn Gly Val Thr Tyr Gln Gln Asn Cys Gln Ala Gly Leu 
    450                 455                 460                 


Val Phe Asp Thr Ser Cys Asp Cys Cys Asn Trp Ala 
465                 470                 475     


<210> 5
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide

<220>
<221> MOD_RES
<222> (2)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Any amino acid

<400> 5
Asp Xaa Xaa Asp Xaa Asp Xaa Glu 
1               5               


<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Any amino acid

<400> 6
Asp Gly Xaa Asp Xaa Asp Xaa Glu 
1               5               


<210> 7
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      6xHis tag

<400> 7
His His His His His His 
1               5       


<210> 8
<211> 379
<212> PRT
<213> Homo sapiens

<400> 8
Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala Gln Tyr Arg Pro Gly 
1               5                   10                  15      


Leu Gly Arg Phe Met Pro Asp Asp Ile Asn Pro Cys Leu Cys Thr His 
            20                  25                  30          


Leu Ile Tyr Ala Phe Ala Gly Met Gln Asn Asn Glu Ile Thr Thr Ile 
        35                  40                  45              


Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe Asn Gly Leu Lys Asn 
    50                  55                  60                  


Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile Gly Gly Trp Asn Phe 
65                  70                  75                  80  


Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln 
                85                  90                  95      


Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe Asp 
            100                 105                 110         


Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly Ser Pro Pro 
        115                 120                 125             


Gln Asp Lys His Leu Phe Thr Val Leu Val Gln Glu Met Arg Glu Ala 
    130                 135                 140                 


Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro Arg Leu Met Val Thr 
145                 150                 155                 160 


Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln Ser Gly Tyr Glu Ile 
                165                 170                 175     


Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His Val Met Thr Tyr Asp 
            180                 185                 190         


Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 
        195                 200                 205             


Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr Leu Asn Val Asp Tyr 
    210                 215                 220                 


Val Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu Lys Leu Ile 
225                 230                 235                 240 


Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile Leu Ser Asn Pro Ser 
                245                 250                 255     


Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala Gly Pro Ala Gly Pro 
            260                 265                 270         


Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu Ile Cys Thr Phe 
        275                 280                 285             


Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala Pro Gln Glu Val Pro 
    290                 295                 300                 


Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr Asp Asn Val Lys Ser 
305                 310                 315                 320 


Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala 
                325                 330                 335     


Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe Cys Asn 
            340                 345                 350         


Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys Ala Leu Gly Leu 
        355                 360                 365             


Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro 
    370                 375                 


<210> 9
<211> 209
<212> PRT
<213> Homo sapiens

<400> 9
Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala Gln Tyr Arg Pro Gly 
1               5                   10                  15      


Leu Gly Arg Phe Met Pro Asp Asp Ile Asn Pro Cys Leu Cys Thr His 
            20                  25                  30          


Leu Ile Tyr Ala Phe Ala Gly Met Gln Asn Asn Glu Ile Thr Thr Ile 
        35                  40                  45              


Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe Asn Gly Leu Lys Asn 
    50                  55                  60                  


Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile Gly Gly Trp Asn Phe 
65                  70                  75                  80  


Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln 
                85                  90                  95      


Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe Asp 
            100                 105                 110         


Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly Ser Pro Pro 
        115                 120                 125             


Gln Asp Lys His Leu Phe Thr Val Leu Val Gln Glu Met Arg Glu Ala 
    130                 135                 140                 


Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro Arg Leu Met Val Thr 
145                 150                 155                 160 


Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln Ser Gly Tyr Glu Ile 
                165                 170                 175     


Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His Val Met Thr Tyr Asp 
            180                 185                 190         


Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 
        195                 200                 205             


Lys 
    


<210> 10
<211> 164
<212> PRT
<213> Homo sapiens

<400> 10
Ser Asn Ala Tyr Leu Asn Val Asp Tyr Val Met Asn Tyr Trp Lys Asp 
1               5                   10                  15      


Asn Gly Ala Pro Ala Glu Lys Leu Ile Val Gly Phe Pro Thr Tyr Gly 
            20                  25                  30          


His Asn Phe Ile Leu Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro 
        35                  40                  45              


Thr Ser Gly Ala Gly Pro Ala Gly Pro Tyr Ala Lys Glu Ser Gly Ile 
    50                  55                  60                  


Trp Ala Tyr Tyr Glu Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Gln 
65                  70                  75                  80  


Gly Trp Asp Ala Pro Gln Glu Val Pro Tyr Ala Tyr Gln Gly Asn Val 
                85                  90                  95      


Trp Val Gly Tyr Asp Asn Val Lys Ser Phe Asp Ile Lys Ala Gln Trp 
            100                 105                 110         


Leu Lys His Asn Lys Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu 
        115                 120                 125             


Asp Asp Phe Thr Gly Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile 
    130                 135                 140                 


Ser Thr Leu Lys Lys Ala Leu Gly Leu Gln Ser Ala Ser Cys Thr Ala 
145                 150                 155                 160 


Pro Ala Gln Pro 
                


<210> 11
<211> 377
<212> PRT
<213> Homo sapiens

<400> 11
Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala Gln Tyr Arg Pro Gly 
1               5                   10                  15      


Leu Gly Arg Phe Met Pro Asp Asp Ile Asn Pro Cys Leu Cys Thr His 
            20                  25                  30          


Leu Ile Tyr Ala Phe Ala Gly Met Gln Asn Asn Glu Ile Thr Thr Ile 
        35                  40                  45              


Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe Asn Gly Leu Lys Asn 
    50                  55                  60                  


Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile Gly Gly Trp Asn Phe 
65                  70                  75                  80  


Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln 
                85                  90                  95      


Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe Asp 
            100                 105                 110         


Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly Ser Pro Pro 
        115                 120                 125             


Gln Asp Lys His Leu Phe Thr Val Leu Val Gln Glu Met Arg Glu Ala 
    130                 135                 140                 


Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro Arg Leu Met Val Thr 
145                 150                 155                 160 


Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln Ser Gly Tyr Glu Ile 
                165                 170                 175     


Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His Val Met Thr Tyr Asp 
            180                 185                 190         


Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 
        195                 200                 205             


Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr Leu Asn Val Asp Tyr 
    210                 215                 220                 


Val Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu Lys Leu Ile 
225                 230                 235                 240 


Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile Leu Ser Asn Pro Ser 
                245                 250                 255     


Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala Gly Pro Ala Gly Pro 
            260                 265                 270         


Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu Ile Cys Thr Phe 
        275                 280                 285             


Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala Pro Gln Glu Val Pro 
    290                 295                 300                 


Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr Asp Asn Val Lys Ser 
305                 310                 315                 320 


Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala 
                325                 330                 335     


Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe Cys Asn 
            340                 345                 350         


Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys Ala Leu Gly Leu 
        355                 360                 365             


Gln Ser Ala Ser Cys Thr Ala Pro Ala 
    370                 375         


<210> 12
<211> 373
<212> PRT
<213> Homo sapiens

<400> 12
Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala Gln Tyr Arg Pro Gly 
1               5                   10                  15      


Leu Gly Arg Phe Met Pro Asp Asp Ile Asn Pro Cys Leu Cys Thr His 
            20                  25                  30          


Leu Ile Tyr Ala Phe Ala Gly Met Gln Asn Asn Glu Ile Thr Thr Ile 
        35                  40                  45              


Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe Asn Gly Leu Lys Asn 
    50                  55                  60                  


Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile Gly Gly Trp Asn Phe 
65                  70                  75                  80  


Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln 
                85                  90                  95      


Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe Asp 
            100                 105                 110         


Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly Ser Pro Pro 
        115                 120                 125             


Gln Asp Lys His Leu Phe Thr Val Leu Val Gln Glu Met Arg Glu Ala 
    130                 135                 140                 


Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro Arg Leu Met Val Thr 
145                 150                 155                 160 


Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln Ser Gly Tyr Glu Ile 
                165                 170                 175     


Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His Val Met Thr Tyr Asp 
            180                 185                 190         


Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 
        195                 200                 205             


Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr Leu Asn Val Asp Tyr 
    210                 215                 220                 


Val Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu Lys Leu Ile 
225                 230                 235                 240 


Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile Leu Ser Asn Pro Ser 
                245                 250                 255     


Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala Gly Pro Ala Gly Pro 
            260                 265                 270         


Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu Ile Cys Thr Phe 
        275                 280                 285             


Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala Pro Gln Glu Val Pro 
    290                 295                 300                 


Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr Asp Asn Val Lys Ser 
305                 310                 315                 320 


Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala 
                325                 330                 335     


Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe Cys Asn 
            340                 345                 350         


Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys Ala Leu Gly Leu 
        355                 360                 365             


Gln Ser Ala Ser Cys 
    370             

