                         SEQUENCE LISTING

<110>  Schepens Eye Research Institute
       Dana, Reza
       Chauhan, Sunil
 
<120>  Therapeutic Compositions for Treatment Of Ocular Inflammatory 
       Diseases

<130>  36770-506001WO

<140>  PCT/US 09/000114
<141>  2009-01-09

<150>  61/010,566
<151>  2008-01-09

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  1859
<212>  DNA
<213>  Homo sapiens

<400>  1
gcaggcacaa actcatccat ccccagttga ttggaagaaa caacgatgac tcctgggaag       60

acctcattgg tgtcactgct actgctgctg agcctggagg ccatagtgaa ggcaggaatc      120

acaatcccac gaaatccagg atgcccaaat tctgaggaca agaacttccc ccggactgtg      180

atggtcaacc tgaacatcca taaccggaat accaatacca atcccaaaag gtcctcagat      240

tactacaacc gatccacctc accttggaat ctccaccgca atgaggaccc tgagagatat      300

ccctctgtga tctgggaggc aaagtgccgc cacttgggct gcatcaacgc tgatgggaac      360

gtggactacc acatgaactc tgtccccatc cagcaagaga tcctggtcct gcgcagggag      420

cctccacact gccccaactc cttccggctg gagaagatac tggtgtccgt gggctgcacc      480

tgtgtcaccc cgattgtcca ccatgtggcc taagagctct ggggagccca cactccccaa      540

agcagttaga ctatggagag ccgacccagc ccctcaggaa ccctcatcct tcaaagacag      600

cctcatttcg gactaaactc attagagttc ttaaggcagt ttgtccaatt aaagcttcag      660

aggtaacact tggccaagat atgagatctg aattaccttt ccctctttcc aagaaggaag      720

gtttgactga gtaccaattt gcttcttgtt tactttttta agggctttaa gttatttatg      780

tatttaatat gccctgagat aactttgggg tataagattc cattttaatg aattacctac      840

tttattttgt ttgtcttttt aaagaagata agattctggg cttgggaatt ttattattta      900

aaaggtaaaa cctgtattta tttgagctat ttaaggatct atttatgttt aagtatttag      960

aaaaaggtga aaaagcacta ttatcagttc tgcctaggta aatgtaagat agaattaaat     1020

ggcagtgcaa aatttctgag tctttacaac atacggatat agtatttcct cctctttgtt     1080

tttaaaagtt ataacatggc tgaaaagaaa gattaaacct actttcatat gtattaattt     1140

aaattttgca atttgttgag gttttacaag agatacagca agtctaactc tctgttccat     1200

taaaccctta taataaaatc cttctgtaat aataaagttt caaaagaaaa tgtttatttg     1260

ttctcattaa atgtatttta gcaaactcag ctcttcccta ttgggaagag ttatgcaaat     1320

tctcctataa gcaaaacaaa gcatgtcttt gagtaacaat gacctggaaa tacccaaaat     1380

tccaagttct cgatttcaca tgccttcaag actgaacacc gactaaggtt ttcatactat     1440

tagccaatgc tgtagacaga agcattttga taggaataga gcaaataaga taatggccct     1500

gaggaatggc atgtcattat taaagatcat atggggaaaa tgaaaccctc cccaaaatac     1560

aagaagttct gggaggagac attgtcttca gactacaatg tccagtttct cccctagact     1620

caggcttcct ttggagatta aggcccctca gagatcaaca gaccaacatt tttctcttcc     1680

tcaagcaaca ctcctagggc ctggcttctg tctgatcaag gcaccacaca acccagaaag     1740

gagctgatgg ggcagaacga actttaagta tgagaaaagt tcagcccaag taaaataaaa     1800

actcaatcac attcaattcc agagtagttt caagtttcac atcgtaacca ttttcgccc      1859


<210>  2
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly 
            20                  25                  30          


Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn 
        35                  40                  45              


Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser 
    50                  55                  60                  


Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu 
65                  70                  75                  80  


Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His 
                85                  90                  95      


Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser 
            100                 105                 110         


Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His 
        115                 120                 125             


Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys 
    130                 135                 140                 


Thr Cys Val Thr Pro Ile Val His His Val Ala 
145                 150                 155 


<210>  3
<211>  711
<212>  DNA
<213>  Homo sapiens

<400>  3
tggggttcca ggcgggcagc agctgcaggc tgaccttgca gcttggcgga atggactggc       60

ctcacaacct gctgtttctt cttaccattt ccatcttcct ggggctgggc cagcccagga      120

gccccaaaag caagaggaag gggcaagggc ggcctgggcc cctggcccct ggccctcacc      180

aggtgccact ggacctggtg tcacggatga aaccgtatgc ccgcatggag gagtatgaga      240

ggaacatcga ggagatggtg gcccagctga ggaacagctc agagctggcc cagagaaagt      300

gtgaggtcaa cttgcagctg tggatgtcca acaagaggag cctgtctccc tggggctaca      360

gcatcaacca cgaccccagc cgtatccccg tggacctgcc ggaggcacgg tgcctgtgtc      420

tgggctgtgt gaaccccttc accatgcagg aggaccgcag catggtgagc gtgccggtgt      480

tcagccaggt tcctgtgcgc cgccgcctct gcccgccacc gccccgcaca gggccttgcc      540

gccagcgcgc agtcatggag accatcgctg tgggctgcac ctgcatcttc tgaatcacct      600

ggcccagaag ccaggccagc agcccgagac catcctcctt gcacctttgt gccaagaaag      660

gcctatgaaa agtaaacact gacttttgaa agcaaaaaaa aaaaaaaaaa a               711


<210>  4
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Trp Pro His Asn Leu Leu Phe Leu Leu Thr Ile Ser Ile Phe 
1               5                   10                  15      


Leu Gly Leu Gly Gln Pro Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln 
            20                  25                  30          


Gly Arg Pro Gly Pro Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp 
        35                  40                  45              


Leu Val Ser Arg Met Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg 
    50                  55                  60                  


Asn Ile Glu Glu Met Val Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala 
65                  70                  75                  80  


Gln Arg Lys Cys Glu Val Asn Leu Gln Leu Trp Met Ser Asn Lys Arg 
                85                  90                  95      


Ser Leu Ser Pro Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile 
            100                 105                 110         


Pro Val Asp Leu Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn 
        115                 120                 125             


Pro Phe Thr Met Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe 
    130                 135                 140                 


Ser Gln Val Pro Val Arg Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr 
145                 150                 155                 160 


Gly Pro Cys Arg Gln Arg Ala Val Met Glu Thr Ile Ala Val Gly Cys 
                165                 170                 175     


Thr Cys Ile Phe 
            180 


<210>  5
<211>  1048
<212>  DNA
<213>  Homo sapiens

<400>  5
gccaggtgtg caggccgctc caagcccagc ctgccccgct gccgccacca tgacgctcct       60

ccccggcctc ctgtttctga cctggctgca cacatgcctg gcccaccatg acccctccct      120

cagggggcac ccccacagtc acggtacccc acactgctac tcggctgagg aactgcccct      180

cggccaggcc cccccacacc tgctggctcg aggtgccaag tgggggcagg ctttgcctgt      240

agccctggtg tccagcctgg aggcagcaag ccacaggggg aggcacgaga ggccctcagc      300

tacgacccag tgcccggtgc tgcggccgga ggaggtgttg gaggcagaca cccaccagcg      360

ctccatctca ccctggagat accgtgtgga cacggatgag gaccgctatc cacagaagct      420

ggccttcgcc gagtgcctgt gcagaggctg tatcgatgca cggacgggcc gcgagacagc      480

tgcgctcaac tccgtgcggc tgctccagag cctgctggtg ctgcgccgcc ggccctgctc      540

ccgcgacggc tcggggctcc ccacacctgg ggcctttgcc ttccacaccg agttcatcca      600

cgtccccgtc ggctgcacct gcgtgctgcc ccgttcagtg tgaccgccga ggccgtgggg      660

cccctagact ggacacgtgt gctccccaga gggcaccccc tatttatgtg tatttattgt      720

tatttatatg cctcccccaa cactaccctt ggggtctggg cattccccgt gtctggagga      780

cagcccccca ctgttctcct catctccagc ctcagtagtt gggggtagaa ggagctcagc      840

acctcttcca gcccttaaag ctgcagaaaa ggtgtcacac ggctgcctgt accttggctc      900

cctgtcctgc tcccggcttc ccttacccta tcactggcct caggcccccg caggctgcct      960

cttcccaacc tccttggaag tacccctgtt tcttaaacaa ttatttaagt gtacgtgtat     1020

tattaaactg atgaacacat ccccaaaa                                        1048


<210>  6
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Leu Leu Pro Gly Leu Leu Phe Leu Thr Trp Leu His Thr Cys 
1               5                   10                  15      


Leu Ala His His Asp Pro Ser Leu Arg Gly His Pro His Ser His Gly 
            20                  25                  30          


Thr Pro His Cys Tyr Ser Ala Glu Glu Leu Pro Leu Gly Gln Ala Pro 
        35                  40                  45              


Pro His Leu Leu Ala Arg Gly Ala Lys Trp Gly Gln Ala Leu Pro Val 
    50                  55                  60                  


Ala Leu Val Ser Ser Leu Glu Ala Ala Ser His Arg Gly Arg His Glu 
65                  70                  75                  80  


Arg Pro Ser Ala Thr Thr Gln Cys Pro Val Leu Arg Pro Glu Glu Val 
                85                  90                  95      


Leu Glu Ala Asp Thr His Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg 
            100                 105                 110         


Val Asp Thr Asp Glu Asp Arg Tyr Pro Gln Lys Leu Ala Phe Ala Glu 
        115                 120                 125             


Cys Leu Cys Arg Gly Cys Ile Asp Ala Arg Thr Gly Arg Glu Thr Ala 
    130                 135                 140                 


Ala Leu Asn Ser Val Arg Leu Leu Gln Ser Leu Leu Val Leu Arg Arg 
145                 150                 155                 160 


Arg Pro Cys Ser Arg Asp Gly Ser Gly Leu Pro Thr Pro Gly Ala Phe 
                165                 170                 175     


Ala Phe His Thr Glu Phe Ile His Val Pro Val Gly Cys Thr Cys Val 
            180                 185                 190         


Leu Pro Arg Ser Val 
        195         


<210>  7
<211>  1873
<212>  DNA
<213>  Homo sapiens

<400>  7
aaaatgtttt cagctcctgg aggcgaaagg tgcagagtcg ctctgtgtcc gtgaggccgg       60

gcggcgacct cgctcagtcg gcttctcggt ccgagtcccc gggtctggat gctggtagcc      120

ggcttcctgc tggcgctgcc gccgagctgg gccgcgggcg ccccgagggc gggcaggcgc      180

cccgcgcggc cgcggggctg cgcggaccgg ccggaggagc tactggagca gctgtacggg      240

cgcctggcgg ccggcgtgct cagtgccttc caccacacgc tgcagctggg gccgcgtgag      300

caggcgcgca acgcgagctg cccggcaggg ggcaggcccg ccgaccgccg cttccggccg      360

cccaccaacc tgcgcagcgt gtcgccctgg gcctacagaa tctcctacga cccggcgagg      420

taccccaggt acctgcctga agcctactgc ctgtgccggg gctgcctgac cgggctgttc      480

ggcgaggagg acgtgcgctt ccgcagcgcc cctgtctaca tgcccaccgt cgtcctgcgc      540

cgcacccccg cctgcgccgg cggccgttcc gtctacaccg aggcctacgt caccatcccc      600

gtgggctgca cctgcgtccc cgagccggag aaggacgcag acagcatcaa ctccagcatc      660

gacaaacagg gcgccaagct cctgctgggc cccaacgacg cgcccgctgg cccctgaggc      720

cggtcctgcc ccgggaggtc tccccggccc gcatcccgag gcgcccaagc tggagccgcc      780

tggagggctc ggtcggcgac ctctgaagag agtgcaccga gcaaaccaag tgccggagca      840

ccagcgccgc ctttccatgg agactcgtaa gcagcttcat ctgacacggg catccctggc      900

ttgcttttag ctacaagcaa gcagcgtggc tggaagctga tgggaaacga cccggcacgg      960

gcatcctgtg tgcggcccgc atggagggtt tggaaaagtt cacggaggct ccctgaggag     1020

cctctcagat cggctgctgc gggtgcaggg cgtgactcac cgctgggtgc ttgccaaaga     1080

gatagggacg catatgcttt ttaaagcaat ctaaaaataa taataagtat agcgactata     1140

tacctacttt taaaatcaac tgttttgaat agaggcagag ctattttata ttatcaaatg     1200

agagctactc tgttacattt cttaacatat aaacatcgtt ttttacttct tctggtagaa     1260

ttttttaaag cataattgga atccttggat aaattttgta gctggtacac tctggcctgg     1320

gtctctgaat tcagcctgtc accgatggct gactgatgaa atggacacgt ctcatctgac     1380

ccactcttcc ttccactgaa ggtcttcacg ggcctccagg tggaccaaag ggatgcacag     1440

gcggctcgca tgccccaggg ccagctaaga gttccaaaga tctcagattt ggttttagtc     1500

atgaatacat aaacagtctc aaactcgcac aattttttcc cccttttgaa agccactggg     1560

gccaatttgt ggttaagagg tggtgagata agaagtggaa cgtgacatct ttgccagttg     1620

tcagaagaat ccaagcaggt attggcttag ttgtaagggc tttaggatca ggctgaatat     1680

gaggacaaag tgggccacgt tagcatctgc agagatcaat ctggaggctt ctgtttctgc     1740

attctgccac gagagctagg tccttgatct tttctttaga ttgaaagtct gtctctgaac     1800

acaattattt gtaaaagtta gtagttcttt tttaaatcat taaaagaggc ttgctgaagg     1860

aaaaaaaaaa aaa                                                        1873


<210>  8
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Val Ala Gly Phe Leu Leu Ala Leu Pro Pro Ser Trp Ala Ala 
1               5                   10                  15      


Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys Ala 
            20                  25                  30          


Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala Ala 
        35                  40                  45              


Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg Glu 
    50                  55                  60                  


Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp Arg 
65                  70                  75                  80  


Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala Tyr 
                85                  90                  95      


Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu Ala 
            100                 105                 110         


Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu Asp 
        115                 120                 125             


Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu Arg 
    130                 135                 140                 


Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala Tyr 
145                 150                 155                 160 


Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys Asp 
                165                 170                 175     


Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu Leu 
            180                 185                 190         


Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro 
        195                 200         


<210>  9
<211>  1335
<212>  DNA
<213>  Homo sapiens

<400>  9
ggcttgctga aaataaaatc aggactccta acctgctcca gtcagcctgc ttccacgagg       60

cctgtcagtc agtgcccgac ttgtgactga gtgtgcagtg cccagcatgt accaggtcag      120

tgcagagggc tgcctgaggg ctgtgctgag agggagagga gcagagatgc tgctgagggt      180

ggagggaggc caagctgcca ggtttggggc tgggggccaa gtggagtgag aaactgggat      240

cccaggggga gggtgcagat gagggagcga cccagattag gtgaggacag ttctctcatt      300

agccttttcc tacaggtggt tgcattcttg gcaatggtca tgggaaccca cacctacagc      360

cactggccca gctgctgccc cagcaaaggg caggacacct ctgaggagct gctgaggtgg      420

agcactgtgc ctgtgcctcc cctagagcct gctaggccca accgccaccc agagtcctgt      480

agggccagtg aagatggacc cctcaacagc agggccatct ccccctggag atatgagttg      540

gacagagact tgaaccggct cccccaggac ctgtaccacg cccgttgcct gtgcccgcac      600

tgcgtcagcc tacagacagg ctcccacatg gacccccggg gcaactcgga gctgctctac      660

cacaaccaga ctgtcttcta caggcggcca tgccatggcg agaagggcac ccacaagggc      720

tactgcctgg agcgcaggct gtaccgtgtt tccttagctt gtgtgtgtgt gcggccccgt      780

gtgatgggct agccggacct gctggaggct ggtccctttt tgggaaacct ggagccaggt      840

gtacaaccac ttgccatgaa gggccaggat gcccagatgc ttggcccctg tgaagtgctg      900

tctggagcag caggatcccg ggacaggatg gggggctttg gggaaaacct gcacttctgc      960

acattttgaa aagagcagct gctgcttagg gccgccggaa gctggtgtcc tgtcattttc     1020

tctcaggaaa ggttttcaaa gttctgccca tttctggagg ccaccactcc tgtctcttcc     1080

tcttttccca tcccctgcta ccctggccca gcacaggcac tttctagata tttccccctt     1140

gctggagaag aaagagcccc tggttttatt tgtttgttta ctcatcactc agtgagcatc     1200

tactttgggt gcattctagt gtagttacta gtcttttgac atggatgatt ctgaggagga     1260

agctgttatt gaatgtatag agatttatcc aaataaatat ctttatttaa aaatgaaaaa     1320

aaaaaaaaaa aaaaa                                                      1335


<210>  10
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Glu Arg Pro Arg Leu Gly Glu Asp Ser Ser Leu Ile Ser Leu 
1               5                   10                  15      


Phe Leu Gln Val Val Ala Phe Leu Ala Met Val Met Gly Thr His Thr 
            20                  25                  30          


Tyr Ser His Trp Pro Ser Cys Cys Pro Ser Lys Gly Gln Asp Thr Ser 
        35                  40                  45              


Glu Glu Leu Leu Arg Trp Ser Thr Val Pro Val Pro Pro Leu Glu Pro 
    50                  55                  60                  


Ala Arg Pro Asn Arg His Pro Glu Ser Cys Arg Ala Ser Glu Asp Gly 
65                  70                  75                  80  


Pro Leu Asn Ser Arg Ala Ile Ser Pro Trp Arg Tyr Glu Leu Asp Arg 
                85                  90                  95      


Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg Cys Leu Cys 
            100                 105                 110         


Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp Pro Arg Gly 
        115                 120                 125             


Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr Arg Arg Pro 
    130                 135                 140                 


Cys His Gly Glu Lys Gly Thr His Lys Gly Tyr Cys Leu Glu Arg Arg 
145                 150                 155                 160 


Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro Arg Val Met 
                165                 170                 175     


Gly 
    


<210>  11
<211>  808
<212>  DNA
<213>  Homo sapiens

<400>  11
gaacacaggc atacacagga agatacattc acagaaagag cttcctgcac aaagtaagcc       60

accagcgcaa catgacagtg aagaccctgc atggcccagc catggtcaag tacttgctgc      120

tgtcgatatt ggggcttgcc tttctgagtg aggcggcagc tcggaaaatc cccaaagtag      180

gacatacttt tttccaaaag cctgagagtt gcccgcctgt gccaggaggt agtatgaagc      240

ttgacattgg catcatcaat gaaaaccagc gcgtttccat gtcacgtaac atcgagagcc      300

gctccacctc cccctggaat tacactgtca cttgggaccc caaccggtac ccctcggaag      360

ttgtacaggc ccagtgtagg aacttgggct gcatcaatgc tcaaggaaag gaagacatct      420

ccatgaattc cgttcccatc cagcaagaga ccctggtcgt ccggaggaag caccaaggct      480

gctctgtttc tttccagttg gagaaggtgc tggtgactgt tggctgcacc tgcgtcaccc      540

ctgtcatcca ccatgtgcag taagaggtgc atatccactc agctgaagaa gctgtagaaa      600

tgccactcct tacccagtgc tctgcaacaa gtcctgtctg acccccaatt ccctccactt      660

cacaggactc ttaataagac ctgcacggat ggaaacagaa aatattcaca atgtatgtgt      720

gtatgtacta cactttatat ttgatatcta aaatgttagg agaaaaatta atatattcag      780

tgctaatata ataaagtatt aataattt                                         808


<210>  12
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Val Lys Thr Leu His Gly Pro Ala Met Val Lys Tyr Leu Leu 
1               5                   10                  15      


Leu Ser Ile Leu Gly Leu Ala Phe Leu Ser Glu Ala Ala Ala Arg Lys 
            20                  25                  30          


Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser Cys Pro 
        35                  40                  45              


Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile Asn Glu 
    50                  55                  60                  


Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser Thr Ser 
65                  70                  75                  80  


Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro Ser Glu 
                85                  90                  95      


Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala Gln Gly 
            100                 105                 110         


Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu Thr Leu 
        115                 120                 125             


Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln Leu Glu 
    130                 135                 140                 


Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val Ile His 
145                 150                 155                 160 


His Val Gln 
            


<210>  13
<211>  3429
<212>  DNA
<213>  Homo sapiens

<400>  13
ctgggcccgg gctggaagcc ggaagcgagc aaagtggagc cgactcgaac tccaccgcgg       60

aaaagaaagc ctcagaacgt tcgttcgctg cgtccccagc cggggccgag ccctccgcga      120

cgccagccgg gccatggggg ccgcacgcag cccgccgtcc gctgtcccgg ggcccctgct      180

ggggctgctc ctgctgctcc tgggcgtgct ggccccgggt ggcgcctccc tgcgactcct      240

ggaccaccgg gcgctggtct gctcccagcc ggggctaaac tgcacggtca agaatagtac      300

ctgcctggat gacagctgga ttcaccctcg aaacctgacc ccctcctccc caaaggacct      360

gcagatccag ctgcactttg cccacaccca acaaggagac ctgttccccg tggctcacat      420

cgaatggaca ctgcagacag acgccagcat cctgtacctc gagggtgcag agttatctgt      480

cctgcagctg aacaccaatg aacgtttgtg cgtcaggttt gagtttctgt ccaaactgag      540

gcatcaccac aggcggtggc gttttacctt cagccacttt gtggttgacc ctgaccagga      600

atatgaggtg accgttcacc acctgcccaa gcccatccct gatggggacc caaaccacca      660

gtccaagaat ttccttgtgc ctgactgtga gcacgccagg atgaaggtaa ccacgccatg      720

catgagctca ggcagcctgt gggaccccaa catcaccgtg gagaccctgg aggcccacca      780

gctgcgtgtg agcttcaccc tgtggaacga atctacccat taccagatcc tgctgaccag      840

ttttccgcac atggagaacc acagttgctt tgagcacatg caccacatac ctgcgcccag      900

accagaagag ttccaccagc gatccaacgt cacactcact ctacgcaacc ttaaagggtg      960

ctgtcgccac caagtgcaga tccagccctt cttcagcagc tgcctcaatg actgcctcag     1020

acactccgcg actgtttcct gcccagaaat gccagacact ccagaaccaa ttccggacta     1080

catgcccctg tgggtgtact ggttcatcac gggcatctcc atcctgctgg tgggctccgt     1140

catcctgctc atcgtctgca tgacctggag gctagctggg cctggaagtg aaaaatacag     1200

tgatgacacc aaatacaccg atggcctgcc tgcggctgac ctgatccccc caccgctgaa     1260

gcccaggaag gtctggatca tctactcagc cgaccacccc ctctacgtgg acgtggtcct     1320

gaaattcgcc cagttcctgc tcaccgcctg cggcacggaa gtggccctgg acctgctgga     1380

agagcaggcc atctcggagg caggagtcat gacctgggtg ggccgtcaga agcaggagat     1440

ggtggagagc aactctaaga tcatcgtcct gtgctcccgc ggcacgcgcg ccaagtggca     1500

ggcgctcctg ggccgggggg cgcctgtgcg gctgcgctgc gaccacggaa agcccgtggg     1560

ggacctgttc actgcagcca tgaacatgat cctcccggac ttcaagaggc cagcctgctt     1620

cggcacctac gtagtctgct acttcagcga ggtcagctgt gacggcgacg tccccgacct     1680

gttcggcgcg gcgccgcggt acccgctcat ggacaggttc gaggaggtgt acttccgcat     1740

ccaggacctg gagatgttcc agccgggccg catgcaccgc gtaggggagc tgtcggggga     1800

caactacctg cggagcccgg gcggcaggca gctccgcgcc gccctggaca ggttccggga     1860

ctggcaggtc cgctgtcccg actggttcga atgtgagaac ctctactcag cagatgacca     1920

ggatgccccg tccctggacg aagaggtgtt tgaggagcca ctgctgcctc cgggaaccgg     1980

catcgtgaag cgggcgcccc tggtgcgcga gcctggctcc caggcctgcc tggccataga     2040

cccgctggtc ggggaggaag gaggagcagc agtggcaaag ctggaacctc acctgcagcc     2100

ccggggtcag ccagcgccgc agcccctcca caccctggtg ctcgccgcag aggagggggc     2160

cctggtggcc gcggtggagc ctgggcccct ggctgacggt gccgcagtcc ggctggcact     2220

ggcgggggag ggcgaggcct gcccgctgct gggcagcccg ggcgctgggc gaaatagcgt     2280

cctcttcctc cccgtggacc ccgaggactc gccccttggc agcagcaccc ccatggcgtc     2340

tcctgacctc cttccagagg acgtgaggga gcacctcgaa ggcttgatgc tctcgctctt     2400

cgagcagagt ctgagctgcc aggcccaggg gggctgcagt agacccgcca tggtcctcac     2460

agacccacac acgccctacg aggaggagca gcggcagtca gtgcagtctg accagggcta     2520

catctccagg agctccccgc agccccccga gggactcacg gaaatggagg aagaggagga     2580

agaggagcag gacccaggga agccggccct gccactctct cccgaggacc tggagagcct     2640

gaggagcctc cagcggcagc tgcttttccg ccagctgcag aagaactcgg gctgggacac     2700

gatggggtca gagtcagagg ggcccagtgc atgagggcgg ctccccaggg accgcccaga     2760

tcccagcttt gagagaggag tgtgtgtgca cgtattcatc tgtgtgtaca tgtctgcatg     2820

tgtatatgtt cgtgtgtgaa atgtaggctt taaaatgtaa atgtctggat tttaatccca     2880

ggcatccctc ctaacttttc tttgtgcagc ggtctggtta tcgtctatcc ccaggggaat     2940

ccacacagcc cgctcccagg agctaatggt agagcgtcct tgaggctcca ttattcgttc     3000

attcagcatt tattgtgcac ctactatgtg gcgggcattt gggataccaa gataaattgc     3060

atgcggcatg gccccagcca tgaaggaact taaccgctag tgccgaggac acgttaaacg     3120

aacaggatgg gccgggcacg gtggctcacg cctgtaatcc cagcacactg ggaggccgag     3180

gcaggtggat cactctgagg tcaggagttt gagccagcct ggccaacatg gtgaaacccc     3240

atctccacta aaaatagaaa aattagccgg gcatggtgac acatgcctgt agtcctagct     3300

acttgggagg ctgaggcagg agaattgctt gaatctggga ggcagaggtt gcagtgagcc     3360

gagattgtgc cattgcactg cagcctggat gacagagcga gactctatct caaaaaaaaa     3420

aaaaaaaaa                                                             3429


<210>  14
<211>  866
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
305                 310                 315                 320 


Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser Val 
                325                 330                 335     


Ile Leu Leu Ile Val Cys Met Thr Trp Arg Leu Ala Gly Pro Gly Ser 
            340                 345                 350         


Glu Lys Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala 
        355                 360                 365             


Asp Leu Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr 
    370                 375                 380                 


Ser Ala Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu 
                405                 410                 415     


Glu Gln Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln 
            420                 425                 430         


Lys Gln Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser 
        435                 440                 445             


Arg Gly Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro 
    450                 455                 460                 


Val Arg Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr 
465                 470                 475                 480 


Ala Ala Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe 
                485                 490                 495     


Gly Thr Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp 
            500                 505                 510         


Val Pro Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg 
        515                 520                 525             


Phe Glu Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro 
    530                 535                 540                 


Gly Arg Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg 
545                 550                 555                 560 


Ser Pro Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp 
                565                 570                 575     


Trp Gln Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser 
            580                 585                 590         


Ala Asp Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu 
        595                 600                 605             


Pro Leu Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val 
    610                 615                 620                 


Arg Glu Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly 
625                 630                 635                 640 


Glu Glu Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro 
                645                 650                 655     


Arg Gly Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala 
            660                 665                 670         


Glu Glu Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp 
        675                 680                 685             


Gly Ala Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro 
    690                 695                 700                 


Leu Leu Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro 
705                 710                 715                 720 


Val Asp Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser 
                725                 730                 735     


Pro Asp Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu Met 
            740                 745                 750         


Leu Ser Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys 
        755                 760                 765             


Ser Arg Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu 
    770                 775                 780                 


Glu Gln Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser 
785                 790                 795                 800 


Ser Pro Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp 
            820                 825                 830         


Leu Glu Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu 
        835                 840                 845             


Gln Lys Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro 
    850                 855                 860                 


Ser Ala 
865     


<210>  15
<211>  2072
<212>  DNA
<213>  Homo sapiens

<400>  15
agcgtgcggg tggcctggat cccgcgcagt ggcccggcga tgtcgctcgt gctgctaagc       60

ctggccgcgc tgtgcaggag cgccgtaccc cgagagccga ccgttcaatg tggctctgaa      120

actgggccat ctccagagtg gatgctacaa catgatctaa tccccggaga cttgagggac      180

ctccgagtag aacctgttac aactagtgtt gcaacagggg actattcaat tttgatgaat      240

gtaagctggg tactccgggc agatgccagc atccgcttgt tgaaggccac caagatttgt      300

gtgacgggca aaagcaactt ccagtcctac agctgtgtga ggtgcaatta cacagaggcc      360

ttccagactc agaccagacc ctctggtggt aaatggacat tttcctacat cggcttccct      420

gtagagctga acacagtcta tttcattggg gcccataata ttcctaatgc aaatatgaat      480

gaagatggcc cttccatgtc tgtgaatttc acctcaccag gctgcctaga ccacataatg      540

aaatataaaa aaaagtgtgt caaggccgga agcctgtggg atccgaacat cactgcttgt      600

aagaagaatg aggagacagt agaagtgaac ttcacaacca ctcccctggg aaacagatac      660

atggctctta tccaacacag cactatcatc gggttttctc aggtgtttga gccacaccag      720

aagaaacaaa cgcgagcttc agtggtgatt ccagtgactg gggatagtga aggtgctacg      780

gtgcagctga ctccatattt tcctacttgt ggcagcgact gcatccgaca taaaggaaca      840

gttgtgctct gcccacaaac aggcgtccct ttccctctgg ataacaacaa aagcaagccg      900

ggaggctggc tgcctctcct cctgctgtct ctgctggtgg ccacatgggt gctggtggca      960

gggatctatc taatgtggag gcacgaaagg atcaagaaga cttccttttc taccaccaca     1020

ctactgcccc ccattaaggt tcttgtggtt tacccatctg aaatatgttt ccatcacaca     1080

atttgttact tcactgaatt tcttcaaaac cattgcagaa gtgaggtcat ccttgaaaag     1140

tggcagaaaa agaaaatagc agagatgggt ccagtgcagt ggcttgccac tcaaaagaag     1200

gcagcagaca aagtcgtctt ccttctttcc aatgacgtca acagtgtgtg cgatggtacc     1260

tgtggcaaga gcgagggcag tcccagtgag aactctcaag acctcttccc ccttgccttt     1320

aaccttttct gcagtgatct aagaagccag attcatctgc acaaatacgt ggtggtctac     1380

tttagagaga ttgatacaaa agacgattac aatgctctca gtgtctgccc caagtaccac     1440

ctcatgaagg atgccactgc tttctgtgca gaacttctcc atgtcaagca gcaggtgtca     1500

gcaggaaaaa gatcacaagc ctgccacgat ggctgctgct ccttgtagcc cacccatgag     1560

aagcaagaga ccttaaaggc ttcctatccc accaattaca gggaaaaaac gtgtgatgat     1620

cctgaagctt actatgcagc ctacaaacag ccttagtaat taaaacattt tataccaata     1680

aaattttcaa atattgctaa ctaatgtagc attaactaac gattggaaac tacatttaca     1740

acttcaaagc tgttttatac atagaaatca attacagttt taattgaaaa ctataaccat     1800

tttgataatg caacaataaa gcatcttcag ccaaacatct agtcttccat agaccatgca     1860

ttgcagtgta cccagaactg tttagctaat attctatgtt taattaatga atactaactc     1920

taagaacccc tcactgattc actcaatagc atcttaagtg aaaaaccttc tattacatgc     1980

aaaaaatcat tgtttttaag ataacaaaag tagggaataa acaagctgaa cccactttta     2040

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                   2072


<210>  16
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser Ala Val 
1               5                   10                  15      


Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro Ser Pro 
            20                  25                  30          


Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg Asp Leu 
        35                  40                  45              


Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr Ser Ile 
    50                  55                  60                  


Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile Arg Leu 
65                  70                  75                  80  


Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe Gln Ser 
                85                  90                  95      


Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr Gln Thr 
            100                 105                 110         


Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe Pro Val 
        115                 120                 125             


Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro Asn Ala 
    130                 135                 140                 


Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro 
145                 150                 155                 160 


Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala 
                165                 170                 175     


Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu 
            180                 185                 190         


Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met 
        195                 200                 205             


Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu 
    210                 215                 220                 


Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr 
225                 230                 235                 240 


Gly Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr 
                245                 250                 255     


Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro 
            260                 265                 270         


Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly 
        275                 280                 285             


Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val 
    290                 295                 300                 


Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys 
305                 310                 315                 320 


Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val 
                325                 330                 335     


Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr 
            340                 345                 350         


Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp 
        355                 360                 365             


Gln Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr 
    370                 375                 380                 


Gln Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val 
385                 390                 395                 400 


Asn Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser 
                405                 410                 415     


Glu Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser 
            420                 425                 430         


Asp Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe 
        435                 440                 445             


Arg Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro 
    450                 455                 460                 


Lys Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu 
465                 470                 475                 480 


His Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His 
                485                 490                 495     


Asp Gly Cys Cys Ser Leu 
            500         


<210>  17
<211>  2691
<212>  DNA
<213>  Homo sapiens

<400>  17
aaaacgaaag cactccgtgc tggaagtagg aggagagtca ggactcccag gacagagagt       60

gcacaaacta cccagcacag ccccctccgc cccctctgga ggctgaagag ggattccagc      120

ccctgccacc cacagacacg ggctgactgg ggtgtctgcc ccccttgggg gggggcagca      180

cagggcctca ggcctgggtg ccacctggca cctagaagat gcctgtgccc tggttcttgc      240

tgtccttggc actgggccga agcccagtgg tcctttctct ggagaggctt gtggggcctc      300

aggacgctac ccactgctct ccggtgagtc tggaaccctg gggagacgag gaaaggctca      360

gggttcagtt tttggctcag caaagcctta gcctggctcc tgtcactgct gccactgcca      420

gaactgccct gtctggtctg tctggtgctg atggtagaag agaagaacgg ggaaggggca      480

agagctgggt ctgtctttct ctgggagggt ctgggaatac ggagccccag aaaaagggcc      540

tctcctgccg cctctgggac agtgacatac tctgcctgcc tggggacatc gtgcctgctc      600

cgggccccgt gctggcgcct acgcacctgc agacagagct ggtgctgagg tgccagaagg      660

agaccgactg tgacctctgt ctgcgtgtgg ctgtccactt ggccgtgcat gggcactggg      720

aagagcctga agatgaggaa aagtttggag gagcagctga ctcaggggtg gaggagccta      780

ggaatgcctc tctccaggcc caagtcgtgc tctccttcca ggcctaccct actgcccgct      840

gcgtcctgct ggaggtgcaa gtgcctgctg cccttgtgca gtttggtcag tctgtgggct      900

ctgtggtata tgactgcttc gaggctgccc tagggagtga ggtacgaatc tggtcctata      960

ctcagcccag gtacgagaag gaactcaacc acacacagca gctgcctgac tgcagggggc     1020

tcgaagtctg gaacagcatc ccgagctgct gggccctgcc ctggctcaac gtgtcagcag     1080

atggtgacaa cgtgcatctg gttctgaatg tctctgagga gcagcacttc ggcctctccc     1140

tgtactggaa tcaggtccag ggccccccaa aaccccggtg gcacaaaaac ctgactggac     1200

cgcagatcat taccttgaac cacacagacc tggttccctg cctctgtatt caggtgtggc     1260

ctctggaacc tgactccgtt aggacgaaca tctgcccctt cagggaggac ccccgcgcac     1320

accagaacct ctggcaagcc gcccgactgc gactgctgac cctgcagagc tggctgctgg     1380

acgcaccgtg ctcgctgccc gcagaagcgg cactgtgctg gcgggctccg ggtggggacc     1440

cctgccagcc actggtccca ccgctttcct gggagaacgt cactgtggac aaggttctcg     1500

agttcccatt gctgaaaggc caccctaacc tctgtgttca ggtgaacagc tcggagaagc     1560

tgcagctgca ggagtgcttg tgggctgact ccctggggcc tctcaaagac gatgtgctac     1620

tgttggagac acgaggcccc caggacaaca gatccctctg tgccttggaa cccagtggct     1680

gtacttcact acccagcaaa gcctccacga gggcagctcg ccttggagag tacttactac     1740

aagacctgca gtcaggccag tgtctgcagc tatgggacga tgacttggga gcgctatggg     1800

cctgccccat ggacaaatac atccacaagc gctgggccct cgtgtggctg gcctgcctac     1860

tctttgccgc tgcgctttcc ctcatcctcc ttctcaaaaa ggatcacgcg aaagggtggc     1920

tgaggctctt gaaacaggac gtccgctcgg gggcggccgc caggggccgc gcggctctgc     1980

tcctctactc agccgatgac tcgggtttcg agcgcctggt gggcgccctg gcgtcggccc     2040

tgtgccagct gccgctgcgc gtggccgtag acctgtggag ccgtcgtgaa ctgagcgcgc     2100

aggggcccgt ggcttggttt cacgcgcagc ggcgccagac cctgcaggag ggcggcgtgg     2160

tggtcttgct cttctctccc ggtgcggtgg cgctgtgcag cgagtggcta caggatgggg     2220

tgtccgggcc cggggcgcac ggcccgcacg acgccttccg cgcctcgctc agctgcgtgc     2280

tgcccgactt cttgcagggc cgggcgcccg gcagctacgt gggggcctgc ttcgacaggc     2340

tgctccaccc ggacgccgta cccgcccttt tccgcaccgt gcccgtcttc acactgccct     2400

cccaactgcc agacttcctg ggggccctgc agcagcctcg cgccccgcgt tccgggcggc     2460

tccaagagag agcggagcaa gtgtcccggg cccttcagcc agccctggat agctacttcc     2520

atcccccggg gactcccgcg ccgggacgcg gggtgggacc aggggcggga cctggggcgg     2580

gggacgggac ttaaataaag gcagacgctg tttttctacc catgtggccc aaaaaaaaaa     2640

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a              2691


<210>  18
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Val Ser Leu Glu Pro Trp Gly Asp Glu Glu Arg Leu Arg 
        35                  40                  45              


Val Gln Phe Leu Ala Gln Gln Ser Leu Ser Leu Ala Pro Val Thr Ala 
    50                  55                  60                  


Ala Thr Ala Arg Thr Ala Leu Ser Gly Leu Ser Gly Ala Asp Gly Arg 
65                  70                  75                  80  


Arg Glu Glu Arg Gly Arg Gly Lys Ser Trp Val Cys Leu Ser Leu Gly 
                85                  90                  95      


Gly Ser Gly Asn Thr Glu Pro Gln Lys Lys Gly Leu Ser Cys Arg Leu 
            100                 105                 110         


Trp Asp Ser Asp Ile Leu Cys Leu Pro Gly Asp Ile Val Pro Ala Pro 
        115                 120                 125             


Gly Pro Val Leu Ala Pro Thr His Leu Gln Thr Glu Leu Val Leu Arg 
    130                 135                 140                 


Cys Gln Lys Glu Thr Asp Cys Asp Leu Cys Leu Arg Val Ala Val His 
145                 150                 155                 160 


Leu Ala Val His Gly His Trp Glu Glu Pro Glu Asp Glu Glu Lys Phe 
                165                 170                 175     


Gly Gly Ala Ala Asp Ser Gly Val Glu Glu Pro Arg Asn Ala Ser Leu 
            180                 185                 190         


Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr Pro Thr Ala Arg Cys 
        195                 200                 205             


Val Leu Leu Glu Val Gln Val Pro Ala Ala Leu Val Gln Phe Gly Gln 
    210                 215                 220                 


Ser Val Gly Ser Val Val Tyr Asp Cys Phe Glu Ala Ala Leu Gly Ser 
225                 230                 235                 240 


Glu Val Arg Ile Trp Ser Tyr Thr Gln Pro Arg Tyr Glu Lys Glu Leu 
                245                 250                 255     


Asn His Thr Gln Gln Leu Pro Asp Cys Arg Gly Leu Glu Val Trp Asn 
            260                 265                 270         


Ser Ile Pro Ser Cys Trp Ala Leu Pro Trp Leu Asn Val Ser Ala Asp 
        275                 280                 285             


Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His Phe 
    290                 295                 300                 


Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro Arg 
305                 310                 315                 320 


Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His Thr 
                325                 330                 335     


Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro Asp 
            340                 345                 350         


Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala His 
        355                 360                 365             


Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser 
    370                 375                 380                 


Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys 
385                 390                 395                 400 


Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro Leu 
                405                 410                 415     


Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu Leu 
            420                 425                 430         


Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys Leu 
        435                 440                 445             


Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp 
    450                 455                 460                 


Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu 
465                 470                 475                 480 


Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser 
                485                 490                 495     


Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser 
            500                 505                 510         


Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala 
        515                 520                 525             


Cys Pro Met Asp Lys Tyr Ile His Lys Arg Trp Ala Leu Val Trp Leu 
    530                 535                 540                 


Ala Cys Leu Leu Phe Ala Ala Ala Leu Ser Leu Ile Leu Leu Leu Lys 
545                 550                 555                 560 


Lys Asp His Ala Lys Gly Trp Leu Arg Leu Leu Lys Gln Asp Val Arg 
                565                 570                 575     


Ser Gly Ala Ala Ala Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala 
            580                 585                 590         


Asp Asp Ser Gly Phe Glu Arg Leu Val Gly Ala Leu Ala Ser Ala Leu 
        595                 600                 605             


Cys Gln Leu Pro Leu Arg Val Ala Val Asp Leu Trp Ser Arg Arg Glu 
    610                 615                 620                 


Leu Ser Ala Gln Gly Pro Val Ala Trp Phe His Ala Gln Arg Arg Gln 
625                 630                 635                 640 


Thr Leu Gln Glu Gly Gly Val Val Val Leu Leu Phe Ser Pro Gly Ala 
                645                 650                 655     


Val Ala Leu Cys Ser Glu Trp Leu Gln Asp Gly Val Ser Gly Pro Gly 
            660                 665                 670         


Ala His Gly Pro His Asp Ala Phe Arg Ala Ser Leu Ser Cys Val Leu 
        675                 680                 685             


Pro Asp Phe Leu Gln Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys 
    690                 695                 700                 


Phe Asp Arg Leu Leu His Pro Asp Ala Val Pro Ala Leu Phe Arg Thr 
705                 710                 715                 720 


Val Pro Val Phe Thr Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala 
                725                 730                 735     


Leu Gln Gln Pro Arg Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala 
            740                 745                 750         


Glu Gln Val Ser Arg Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe His 
        755                 760                 765             


Pro Pro Gly Thr Pro Ala Pro Gly Arg Gly Val Gly Pro Gly Ala Gly 
    770                 775                 780                 


Pro Gly Ala Gly Asp Gly Thr 
785                 790     


<210>  19
<211>  2478
<212>  DNA
<213>  Homo sapiens

<400>  19
aaaacgaaag cactccgtgc tggaagtagg aggagagtca ggactcccag gacagagagt       60

gcacaaacta cccagcacag ccccctccgc cccctctgga ggctgaagag ggattccagc      120

ccctgccacc cacagacacg ggctgactgg ggtgtctgcc ccccttgggg gggggcagca      180

cagggcctca ggcctgggtg ccacctggca cctagaagat gcctgtgccc tggttcttgc      240

tgtccttggc actgggccga agcccagtgg tcctttctct ggagaggctt gtggggcctc      300

aggacgctac ccactgctct ccgggcctct cctgccgcct ctgggacagt gacatactct      360

gcctgcctgg ggacatcgtg cctgctccgg gccccgtgct ggcgcctacg cacctgcaga      420

cagagctggt gctgaggtgc cagaaggaga ccgactgtga cctctgtctg cgtgtggctg      480

tccacttggc cgtgcatggg cactgggaag agcctgaaga tgaggaaaag tttggaggag      540

cagctgactc aggggtggag gagcctagga atgcctctct ccaggcccaa gtcgtgctct      600

ccttccaggc ctaccctact gcccgctgcg tcctgctgga ggtgcaagtg cctgctgccc      660

ttgtgcagtt tggtcagtct gtgggctctg tggtatatga ctgcttcgag gctgccctag      720

ggagtgaggt acgaatctgg tcctatactc agcccaggta cgagaaggaa ctcaaccaca      780

cacagcagct gcctgactgc agggggctcg aagtctggaa cagcatcccg agctgctggg      840

ccctgccctg gctcaacgtg tcagcagatg gtgacaacgt gcatctggtt ctgaatgtct      900

ctgaggagca gcacttcggc ctctccctgt actggaatca ggtccagggc cccccaaaac      960

cccggtggca caaaaacctg actggaccgc agatcattac cttgaaccac acagacctgg     1020

ttccctgcct ctgtattcag gtgtggcctc tggaacctga ctccgttagg acgaacatct     1080

gccccttcag ggaggacccc cgcgcacacc agaacctctg gcaagccgcc cgactgcgac     1140

tgctgaccct gcagagctgg ctgctggacg caccgtgctc gctgcccgca gaagcggcac     1200

tgtgctggcg ggctccgggt ggggacccct gccagccact ggtcccaccg ctttcctggg     1260

agaacgtcac tgtggacaag gttctcgagt tcccattgct gaaaggccac cctaacctct     1320

gtgttcaggt gaacagctcg gagaagctgc agctgcagga gtgcttgtgg gctgactccc     1380

tggggcctct caaagacgat gtgctactgt tggagacacg aggcccccag gacaacagat     1440

ccctctgtgc cttggaaccc agtggctgta cttcactacc cagcaaagcc tccacgaggg     1500

cagctcgcct tggagagtac ttactacaag acctgcagtc aggccagtgt ctgcagctat     1560

gggacgatga cttgggagcg ctatgggcct gccccatgga caaatacatc cacaagcgct     1620

gggccctcgt gtggctggcc tgcctactct ttgccgctgc gctttccctc atcctccttc     1680

tcaaaaagga tcacgcgaaa gggtggctga ggctcttgaa acaggacgtc cgctcggggg     1740

cggccgccag gggccgcgcg gctctgctcc tctactcagc cgatgactcg ggtttcgagc     1800

gcctggtggg cgccctggcg tcggccctgt gccagctgcc gctgcgcgtg gccgtagacc     1860

tgtggagccg tcgtgaactg agcgcgcagg ggcccgtggc ttggtttcac gcgcagcggc     1920

gccagaccct gcaggagggc ggcgtggtgg tcttgctctt ctctcccggt gcggtggcgc     1980

tgtgcagcga gtggctacag gatggggtgt ccgggcccgg ggcgcacggc ccgcacgacg     2040

ccttccgcgc ctcgctcagc tgcgtgctgc ccgacttctt gcagggccgg gcgcccggca     2100

gctacgtggg ggcctgcttc gacaggctgc tccacccgga cgccgtaccc gcccttttcc     2160

gcaccgtgcc cgtcttcaca ctgccctccc aactgccaga cttcctgggg gccctgcagc     2220

agcctcgcgc cccgcgttcc gggcggctcc aagagagagc ggagcaagtg tcccgggccc     2280

ttcagccagc cctggatagc tacttccatc ccccggggac tcccgcgccg ggacgcgggg     2340

tgggaccagg ggcgggacct ggggcggggg acgggactta aataaaggca gacgctgttt     2400

ttctacccat gtggcccaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2460

aaaaaaaaaa aaaaaaaa                                                   2478


<210>  20
<211>  720
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala 
        195                 200                 205             


Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val 
    210                 215                 220                 


Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn 
225                 230                 235                 240 


Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly 
                245                 250                 255     


Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys 
            260                 265                 270         


Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys 
        275                 280                 285             


Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala 
    290                 295                 300                 


Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys 
305                 310                 315                 320 


Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp 
                325                 330                 335     


Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val 
            340                 345                 350         


Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys 
        355                 360                 365             


Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp 
    370                 375                 380                 


Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr 
385                 390                 395                 400 


Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly 
                405                 410                 415     


Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly 
            420                 425                 430         


Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp 
        435                 440                 445             


Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile 
    450                 455                 460                 


His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala 
465                 470                 475                 480 


Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Gly Trp 
                485                 490                 495     


Leu Arg Leu Leu Lys Gln Asp Val Arg Ser Gly Ala Ala Ala Arg Gly 
            500                 505                 510         


Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu Arg 
        515                 520                 525             


Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg Val 
    530                 535                 540                 


Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro Val 
545                 550                 555                 560 


Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly Val 
                565                 570                 575     


Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser Glu Trp 
            580                 585                 590         


Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro His Asp Ala 
        595                 600                 605             


Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln Gly Arg 
    610                 615                 620                 


Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu His Pro 
625                 630                 635                 640 


Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr Leu Pro 
                645                 650                 655     


Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala Pro 
            660                 665                 670         


Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg Ala Leu 
        675                 680                 685             


Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro Ala Pro 
    690                 695                 700                 


Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly Thr 
705                 710                 715                 720 


<210>  21
<211>  2433
<212>  DNA
<213>  Homo sapiens

<400>  21
aaaacgaaag cactccgtgc tggaagtagg aggagagtca ggactcccag gacagagagt       60

gcacaaacta cccagcacag ccccctccgc cccctctgga ggctgaagag ggattccagc      120

ccctgccacc cacagacacg ggctgactgg ggtgtctgcc ccccttgggg gggggcagca      180

cagggcctca ggcctgggtg ccacctggca cctagaagat gcctgtgccc tggttcttgc      240

tgtccttggc actgggccga agcccagtgg tcctttctct ggagaggctt gtggggcctc      300

aggacgctac ccactgctct ccgggcctct cctgccgcct ctgggacagt gacatactct      360

gcctgcctgg ggacatcgtg cctgctccgg gccccgtgct ggcgcctacg cacctgcaga      420

cagagctggt gctgaggtgc cagaaggaga ccgactgtga cctctgtctg cgtgtggctg      480

tccacttggc cgtgcatggg cactgggaag agcctgaaga tgaggaaaag tttggaggag      540

cagctgactc aggggtggag gagcctagga atgcctctct ccaggcccaa gtcgtgctct      600

ccttccaggc ctaccctact gcccgctgcg tcctgctgga ggtgcaagtg cctgctgccc      660

ttgtgcagtt tggtcagtct gtgggctctg tggtatatga ctgcttcgag gctgccctag      720

ggagtgaggt acgaatctgg tcctatactc agcccaggta cgagaaggaa ctcaaccaca      780

cacagcagct gcctgccctg ccctggctca acgtgtcagc agatggtgac aacgtgcatc      840

tggttctgaa tgtctctgag gagcagcact tcggcctctc cctgtactgg aatcaggtcc      900

agggcccccc aaaaccccgg tggcacaaaa acctgactgg accgcagatc attaccttga      960

accacacaga cctggttccc tgcctctgta ttcaggtgtg gcctctggaa cctgactccg     1020

ttaggacgaa catctgcccc ttcagggagg acccccgcgc acaccagaac ctctggcaag     1080

ccgcccgact gcgactgctg accctgcaga gctggctgct ggacgcaccg tgctcgctgc     1140

ccgcagaagc ggcactgtgc tggcgggctc cgggtgggga cccctgccag ccactggtcc     1200

caccgctttc ctgggagaac gtcactgtgg acaaggttct cgagttccca ttgctgaaag     1260

gccaccctaa cctctgtgtt caggtgaaca gctcggagaa gctgcagctg caggagtgct     1320

tgtgggctga ctccctgggg cctctcaaag acgatgtgct actgttggag acacgaggcc     1380

cccaggacaa cagatccctc tgtgccttgg aacccagtgg ctgtacttca ctacccagca     1440

aagcctccac gagggcagct cgccttggag agtacttact acaagacctg cagtcaggcc     1500

agtgtctgca gctatgggac gatgacttgg gagcgctatg ggcctgcccc atggacaaat     1560

acatccacaa gcgctgggcc ctcgtgtggc tggcctgcct actctttgcc gctgcgcttt     1620

ccctcatcct ccttctcaaa aaggatcacg cgaaagggtg gctgaggctc ttgaaacagg     1680

acgtccgctc gggggcggcc gccaggggcc gcgcggctct gctcctctac tcagccgatg     1740

actcgggttt cgagcgcctg gtgggcgccc tggcgtcggc cctgtgccag ctgccgctgc     1800

gcgtggccgt agacctgtgg agccgtcgtg aactgagcgc gcaggggccc gtggcttggt     1860

ttcacgcgca gcggcgccag accctgcagg agggcggcgt ggtggtcttg ctcttctctc     1920

ccggtgcggt ggcgctgtgc agcgagtggc tacaggatgg ggtgtccggg cccggggcgc     1980

acggcccgca cgacgccttc cgcgcctcgc tcagctgcgt gctgcccgac ttcttgcagg     2040

gccgggcgcc cggcagctac gtgggggcct gcttcgacag gctgctccac ccggacgccg     2100

tacccgccct tttccgcacc gtgcccgtct tcacactgcc ctcccaactg ccagacttcc     2160

tgggggccct gcagcagcct cgcgccccgc gttccgggcg gctccaagag agagcggagc     2220

aagtgtcccg ggcccttcag ccagccctgg atagctactt ccatcccccg gggactcccg     2280

cgccgggacg cggggtggga ccaggggcgg gacctggggc gggggacggg acttaaataa     2340

aggcagacgc tgtttttcta cccatgtggc ccaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2400

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                  2433


<210>  22
<211>  705
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu 
        195                 200                 205             


Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp 
    210                 215                 220                 


Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr 
225                 230                 235                 240 


Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu 
                245                 250                 255     


Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile 
            260                 265                 270         


Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala 
        275                 280                 285             


Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro 
    290                 295                 300                 


Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly 
305                 310                 315                 320 


Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr 
                325                 330                 335     


Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu 
            340                 345                 350         


Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu 
        355                 360                 365             


Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu 
    370                 375                 380                 


Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser 
385                 390                 395                 400 


Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu 
                405                 410                 415     


Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu 
            420                 425                 430         


Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr 
        435                 440                 445             


Ile His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala 
    450                 455                 460                 


Ala Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Gly 
465                 470                 475                 480 


Trp Leu Arg Leu Leu Lys Gln Asp Val Arg Ser Gly Ala Ala Ala Arg 
                485                 490                 495     


Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu 
            500                 505                 510         


Arg Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg 
        515                 520                 525             


Val Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro 
    530                 535                 540                 


Val Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly 
545                 550                 555                 560 


Val Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser Glu 
                565                 570                 575     


Trp Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro His Asp 
            580                 585                 590         


Ala Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln Gly 
        595                 600                 605             


Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu His 
    610                 615                 620                 


Pro Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr Leu 
625                 630                 635                 640 


Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala 
                645                 650                 655     


Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg Ala 
            660                 665                 670         


Leu Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro Ala 
        675                 680                 685             


Pro Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly 
    690                 695                 700                 


Thr 
705 


<210>  23
<211>  8720
<212>  DNA
<213>  Homo sapiens

<400>  23
gcggccgccg cggccaccgc ccactcgggg ctggccagcg gcgggcggcc ggggcgcaga       60

gaacggcctg gctgggcgag cgcacggcca tggccccgtg gctgcagctc tgctccgtct      120

tctttacggt caacgcctgc ctcaacggct cgcagctggc tgtggccgct ggcgggtccg      180

gccgcgcgcg gggcgccgac acctgtggct ggaggggagt ggggccagcc agcagaaaca      240

gtgggctgta caacatcacc ttcaaatatg acaattgtac cacctacttg aatccagtgg      300

ggaagcatgt gattgctgac gcccagaata tcaccatcag ccagtatgct tgccatgacc      360

aagtggcagt caccattctt tggtccccag gggccctcgg catcgaattc ctgaaaggat      420

ttcgggtaat actggaggag ctgaagtcgg agggaagaca gtgccaacaa ctgattctaa      480

aggatccgaa gcagctcaac agtagcttca aaagaactgg aatggaatct caacctttcc      540

tgaatatgaa atttgaaacg gattatttcg taaaggttgt cccttttcct tccattaaaa      600

acgaaagcaa ttaccaccct ttcttcttta gaacccgagc ctgtgacctg ttgttacagc      660

cggacaatct agcttgtaaa cccttctgga agcctcggaa cctgaacatc agccagcatg      720

gctcggacat gcaggtgtcc ttcgaccatg caccgcacaa cttcggcttc cgtttcttct      780

atcttcacta caagctcaag cacgaaggac ctttcaagcg aaagacctgt aagcaggagc      840

aaactacaga gacgaccagc tgcctccttc aaaatgtttc tccaggggat tatataattg      900

agctggtgga tgacactaac acaacaagaa aagtgatgca ttatgcctta aagccagtgc      960

actccccgtg ggccgggccc atcagagccg tggccatcac agtgccactg gtagtcatat     1020

cggcattcgc gacgctcttc actgtgatgt gccgcaagaa gcaacaagaa aatatatatt     1080

cacatttaga tgaagagagc tctgagtctt ccacatacac tgcagcactc ccaagagaga     1140

ggctccggcc gcggccgaag gtctttctct gctattccag taaagatggc cagaatcaca     1200

tgaatgtcgt ccagtgtttc gcctacttcc tccaggactt ctgtggctgt gaggtggctc     1260

tggacctgtg ggaagacttc agcctctgta gagaagggca gagagaatgg gtcatccaga     1320

agatccacga gtcccagttc atcattgtgg tttgttccaa aggtatgaag tactttgtgg     1380

acaagaagaa ctacaaacac aaaggaggtg gccgaggctc ggggaaagga gagctcttcc     1440

tggtggcggt gtcagccatt gccgaaaagc tccgccaggc caagcagagt tcgtccgcgg     1500

cgctcagcaa gtttatcgcc gtctactttg attattcctg cgagggagac gtccccggta     1560

tcctagacct gagtaccaag tacagactca tggacaatct tcctcagctc tgttcccact     1620

tgcactcccg agaccacggc ctccaggagc cggggcagca cacgcgacag ggcagcagaa     1680

ggaactactt ccggagcaag tcaggccggt ccctatacgt cgccatttgc aacatgcacc     1740

agtttattga cgaggagccc gactggttcg aaaagcagtt cgttcccttc catcctcctc     1800

cactgcgcta ccgggagcca gtcttggaga aatttgattc gggcttggtt ttaaatgatg     1860

tcatgtgcaa accagggcct gagagtgact tctgcctaaa ggtagaggcg gctgttcttg     1920

gggcaaccgg accagccgac tcccagcacg agagtcagca tgggggcctg gaccaagacg     1980

gggaggcccg gcctgccctt gacggtagcg ccgccctgca acccctgctg cacacggtga     2040

aagccggcag cccctcggac atgccgcggg actcaggcat ctatgactcg tctgtgccct     2100

catccgagct gtctctgcca ctgatggaag gactctcgac ggaccagaca gaaacgtctt     2160

ccctgacgga gagcgtgtcc tcctcttcag gcctgggtga ggaggaacct cctgcccttc     2220

cttccaagct cctctcttct gggtcatgca aagcagatct tggttgccgc agctacactg     2280

atgaactcca cgcggtcgcc cctttgtaac aaaacgaaag agtctaagca ttgccacttt     2340

agctgctgcc tccctctgat tccccagctc atctccctgg ttgcatggcc cacttggagc     2400

tgaggtctca tacaaggata tttggagtga aatgctggcc agtacttgtt ctcccttgcc     2460

ccaacccttt accggatatc ttgacaaact ctccaatttt ctaaaatgat atggagctct     2520

gaaaggcatg tccataaggt ctgacaacag cttgccaaat ttggttagtc cttggatcag     2580

agcctgttgt gggaggtagg gaggaaatat gtaaagaaaa acaggaagat acctgcacta     2640

atcattcaga cttcattgag ctctgcaaac tttgcctgtt tgctattggc taccttgatt     2700

tgaaatgctt tgtgaaaaaa ggcactttta acatcatagc cacagaaatc aagtgccagt     2760

ctatctggaa tccatgttgt attgcagata atgttctcat ttatttttga tgtagaattt     2820

acattgccat gggtgttaaa taagctttga gtcaaaagtc aagaaagtga ctgaatatac     2880

agtcaccttt tatgaaatga gtctctgtgt tactgggtgg catgactgat tgaggtgaag     2940

ctcacggggc caggctgacc gtcttgaccg ttccacttga gataggttgg tcatcgtgca     3000

gaaggcccca ggacctcagc acacacagcc tcctcttggt ctgagtaggc atcatgtggg     3060

ggccagatct gcctgctgtt tccatgggtt acatttactg tgctgtatct cagatgttgg     3120

tgtctggaag tttattctta agagactgct acccagctgg tctgtattat tggaagttgc     3180

agttcgtgct ttggttggcc ttctggtcta aagctgtgtc ctgaatatta gggatcacaa     3240

ttcactgaaa tacagcagtg tgtggaggtg atggccagtt aatctgctga actggttttg     3300

actaatgaca aacctctttt taagatggta gaatggaggt gatagtcaca aaagtaaatg     3360

ttccattttt atgaatgact ttctacagag tttctatttc taaagaaaaa acaattgttc     3420

acatcccatc tgatgattag catgtgtgta atgaatgctg tcttggtctc ccctgtggaa     3480

acccttctcc ctgtgcctta gagcaggtgt gtacatctct cactaccttt ctcatgggtg     3540

ctgttagatt ttggcacccg ttttctcagc attcagccca gggaatgtgg ttttcacttc     3600

ttcgtcagat aagaccaaca tgaaggggta tgttgagaaa catcctgagg caaggtggga     3660

ggtgggatgg ggcaggactt tcccttccaa gcacatgcat ggcaggtggg gaaagggggg     3720

cttgcacccc tgctggaaag aaaaggtttg tgtatatttc tgatgcaaat gtcatactca     3780

ctgctctgta aaggcagctg gcagcttttt gggaaaagaa cgtgctcgtc tgttctctgg     3840

catcaagttt cttgcagctg ctctgaggga gagacagtga gctgcaagac tgcctcccca     3900

taacaacagg caactcagag aagagtcatt ttatgttgtt cctatggaat ctggaatgag     3960

tgcagagctc ctacccacac atgactgccc cgccatttca tcctaggcat tctgtgaagg     4020

agattggtta gtccaaactt gctaacatac gaaaattcac ttggaacatg atgagagatt     4080

tcttattgag gccaagagat gtttcctgtc ccagaggaac cattaggagt cgcttttagg     4140

gtattcagct ttgttcatga aataaggcat ctctgagaaa gtggccccag ggagagaatg     4200

gaggactggg aggagaagca ttaactgagc tccaagggtg tgtgggcaga gagcttgcta     4260

tgtgaactca ctccttaaga aaatggaaga gaaaaagaga gtgctagtta aaaaatcggg     4320

atgttttagt ttggatttag ggttttgata cttatgttga aatactaatg tttctgatca     4380

ataaaatcaa actcttaata taccgagtaa tgaaaccata gtgtgattgc ctcagaataa     4440

attgagaagt ccaacttcct agttttgttt aattagtttc actttttcta ctctccccag     4500

tatgctagaa atgggaatcg ttgccctgca gattacggca aaacatctgt tttaagcaaa     4560

gctgcatttt ttgactcaga aattgtccca gacggtggat ataagatgaa attcagaaaa     4620

acgttctgcc aagtcacagg cttttagata ttatggaaac aagaaatgga aaacaggatg     4680

atctccatga gaggccttga tcctgagagt aaaaggcttg tgtagatagg ttagacaacg     4740

tcctctagaa aagagaccag ggataagtcc aggtttccag gaaaaccaag aagcctgcgg     4800

gtagctgaag gtagagtgct agttgttcat cttaacttac caatgagcta cagaaaggac     4860

ttagcatctg atgtcatcag ctttgccagg agagtgatca aggaggttaa agctcaggta     4920

aaggtgtgcc ttctcagaga ttggctacaa gcaacagaga ccacctcaac agagaccacc     4980

tcaacagact cagcccagcc atacaaggtg ccaaagctcc tccagagggc tgtcttgggc     5040

ctttgaggca attgatctcc agaaagagtc agaagtcatt ccagtccagg cccaggtatt     5100

cagatggtga cccagccaga taatagtatc ttgagcaaat aatagtatct tgagtgcaaa     5160

taagcaggaa gactgtcctt caaaaaatgt ggggttacat gattttcaga gccttttttt     5220

cagagttgag catcttttct tttaaaagaa ataaggggca agaggaccaa ttttattcct     5280

tgaggaaaaa tgacacaccc ttctcccaaa agaaagaaaa ctctctggcc ccccaacttc     5340

aacactaatt tggctccctg aagaagagag aaaatattat ttctgtcttt attgaagaga     5400

aatgggcaat gccaatgtga aggttactag tcttttttat tttctattgg tgaagactac     5460

tactgctctt atttagcaga tcttatacct tcagtggtca ccagtatagc aggtgaggta     5520

taaggaaaac agcagtgtga tgataaatgg taattaatat actttgtctg tgtcagcaat     5580

agggaatggt ggggactgtg gcaaactgaa gcgcccctgt tccacccaca gtgggtaatt     5640

ttccagtcga ctgtggccat gaagtacttc ctgatcttcc catttttcaa gaaaagctga     5700

caatctggat ttttatatga aaaattctga ttttaaaaaa tattggcaac taagttaaaa     5760

ttcaagtgaa tttagaccca gcagaagaca tggatggacc tgatttggtc cactgactac     5820

cagtttgtta acctgtgctt tataagattt gaaggaaagg cattcatggt aattacagac     5880

ggtgccacca gaaaatgctc ttgctaaatg cagccagtag ttagattgct tctttctcca     5940

gtctcccccg caaagaaatt tgacgtgatt ctgaatgcac tggacatgtc ttgattgcgt     6000

ctttacattt cacagtgtct taaaagaaag gcaagccagt tgttaatttc agaatcagat     6060

ttatgctctc tcaatttaaa aaatgctggg aacaatttca tttttttttt tttgagatgg     6120

agtcttgctc tgttgcccag gctggagtgc agtggcgtga tctcggctca ctgcaagctc     6180

cacctcccgg gttcacgcca ttctcctgcc tcagcctcct gagtagctgg gactacaggc     6240

gcccaccacc acgcctggct aatttttttg tatttttagt agagacgggg tttcactgtg     6300

ttagccagga tgatctcgat ctcctgacct ggtgatccgc ttgcctcggc ctcccaaagt     6360

gctgggatta caggcgtgag ccactgcgcc cggcctaaca atttcattta aactccacaa     6420

cctaaagggc tttgtttata gttttagctc ttggcataat ttttttcagg tggtgtgcaa     6480

ttctgagcat aggccaagac atgattagga aagcaggcag ttgtagagag taaggcaagg     6540

aacctcctag cgtccattag agccaggtat ttgcattatc ttccgtttta agtggtctgt     6600

gaattgactg tgttttggag gtgtgaaaca gtatacagag aaaagctttt cctgatactg     6660

agatatcagt taggagtcca aatggggtgt tgggtcatcc ttgccatatc acctcctttc     6720

caggctcaga gtgaaaatag acaaaaggaa atctgactgc aagccagtgg ctttgattcc     6780

agtttcagag tttagggact aggagagagt ttagattatc tagcatattc tccccctggt     6840

gtcagacagg gctgtgcctg aattattcca gacatatggc tgtagatggt attctttatt     6900

ttataagaag gagattctgt aacctaccct gctgatcaga tagttctttg tatgtcttag     6960

agaaattcaa gccagcttcc ttttgttcgg cttgtagtgg agaaagaaca gctggtcacc     7020

ttccatgtat tcaaaaacca cagtgaagtc atccccctgg tgtttttatt tcagtgataa     7080

ataattccac ccacttaaac cattcttcat ggctcttgtt ttccaggggc ctaataattt     7140

tcactgctgt aatgtttctc agcttcacac ttagtttagt tgcccaaaca atgttggtgc     7200

cttactcaca ttggtgcctt gtgaagacga ggctcaggat ggggattatg gggaaattct     7260

tgcacaccca gctcctctta ccacttaaaa atataatggc actttcacaa aatgatatgt     7320

cacctatatt cattgagaat tatttgactg ccacattttt cccctgatga tagtcatcta     7380

tcataacttg tgtttgtttt cctcctgaga tcaaacactt ggtgcttatt cctgatgtat     7440

actctgagac cagctcttac cttctgagtg gcagctaccc ctccctccca attttagatc     7500

ctatttttac acatctctat agatatcacc tttatttcat gactcacaat attaaatggt     7560

acagacttca gtttaaccac tggtgtggta acagcagtag ttgctaagta ccaccttccc     7620

attgctgttt gagggctaat ttgcaaagac atttgaatct cccagtgaag atgtctgggg     7680

aattttggcc agttgtcttc cctcttgccc ttttgttctt taaaattcag cttggaccat     7740

agacacctcc aggatcttgt ttatgttctg ctctcaattg accaagcact gcgttttgca     7800

caatcagaag tctcacaaaa gcaaacagtt atgactgcat atctgatgtt tatatcctat     7860

aaaatttcag gaagattcag agtcaatctt ctatttgtac atgatgtaga caaaattagc     7920

tgctccaatt gttagacaaa aaattgccat tggattacac taatgtgctc atctgttgtt     7980

ttaaaagttt ggtatcaggc ggggcacggt ggctcacgcc tgtaatccca gcattttggg     8040

aggccaaggt gggcggatca cctgaggtcc agagttcaag accagcctga ccaacatggt     8100

gaaaccctgt ctctactaaa aatacaaaat taatcaggcg tggttgtgtg tgcctgtaat     8160

cccagctact cgagaggctg aggcaggaga atcgcttgaa tccgggaggc agaggttgca     8220

gtgagctgag atcacgccat tgcactctag cctgggcaac aagagcgaaa ctccgtctca     8280

acaacaacaa caaaaagttt ggtatgtttc tctcaagaaa aaagcatggt gagtccagac     8340

agcagcaaaa gcttttgtga aaaccaattg tgttcatcta gatagtaagt aactcctatt     8400

tttactgtta attttttaaa agagaatttt tccctgtgga aactccctgt tagtacgtcc     8460

taggggagaa agcctgtgga atatggtggt tattgatggc gttgcctttg tttcatcttt     8520

gagtttgccc tttgtgggat ctagtgggat aatgagcact gacagaactc ttaacagcgt     8580

gctgtatttt tgacattgaa aatgttaatg acttgatttg tacataactc tgtaactagg     8640

tgaaagtaga tcacagctga catttacaaa atgtttttgt accttagaat ttctgcatta     8700

aataaaatgt tttgttttaa                                                 8720


<210>  24
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Pro Trp Leu Gln Leu Cys Ser Val Phe Phe Thr Val Asn Ala 
1               5                   10                  15      


Cys Leu Asn Gly Ser Gln Leu Ala Val Ala Ala Gly Gly Ser Gly Arg 
            20                  25                  30          


Ala Arg Gly Ala Asp Thr Cys Gly Trp Arg Gly Val Gly Pro Ala Ser 
        35                  40                  45              


Arg Asn Ser Gly Leu Tyr Asn Ile Thr Phe Lys Tyr Asp Asn Cys Thr 
    50                  55                  60                  


Thr Tyr Leu Asn Pro Val Gly Lys His Val Ile Ala Asp Ala Gln Asn 
65                  70                  75                  80  


Ile Thr Ile Ser Gln Tyr Ala Cys His Asp Gln Val Ala Val Thr Ile 
                85                  90                  95      


Leu Trp Ser Pro Gly Ala Leu Gly Ile Glu Phe Leu Lys Gly Phe Arg 
            100                 105                 110         


Val Ile Leu Glu Glu Leu Lys Ser Glu Gly Arg Gln Cys Gln Gln Leu 
        115                 120                 125             


Ile Leu Lys Asp Pro Lys Gln Leu Asn Ser Ser Phe Lys Arg Thr Gly 
    130                 135                 140                 


Met Glu Ser Gln Pro Phe Leu Asn Met Lys Phe Glu Thr Asp Tyr Phe 
145                 150                 155                 160 


Val Lys Val Val Pro Phe Pro Ser Ile Lys Asn Glu Ser Asn Tyr His 
                165                 170                 175     


Pro Phe Phe Phe Arg Thr Arg Ala Cys Asp Leu Leu Leu Gln Pro Asp 
            180                 185                 190         


Asn Leu Ala Cys Lys Pro Phe Trp Lys Pro Arg Asn Leu Asn Ile Ser 
        195                 200                 205             


Gln His Gly Ser Asp Met Gln Val Ser Phe Asp His Ala Pro His Asn 
    210                 215                 220                 


Phe Gly Phe Arg Phe Phe Tyr Leu His Tyr Lys Leu Lys His Glu Gly 
225                 230                 235                 240 


Pro Phe Lys Arg Lys Thr Cys Lys Gln Glu Gln Thr Thr Glu Thr Thr 
                245                 250                 255     


Ser Cys Leu Leu Gln Asn Val Ser Pro Gly Asp Tyr Ile Ile Glu Leu 
            260                 265                 270         


Val Asp Asp Thr Asn Thr Thr Arg Lys Val Met His Tyr Ala Leu Lys 
        275                 280                 285             


Pro Val His Ser Pro Trp Ala Gly Pro Ile Arg Ala Val Ala Ile Thr 
    290                 295                 300                 


Val Pro Leu Val Val Ile Ser Ala Phe Ala Thr Leu Phe Thr Val Met 
305                 310                 315                 320 


Cys Arg Lys Lys Gln Gln Glu Asn Ile Tyr Ser His Leu Asp Glu Glu 
                325                 330                 335     


Ser Ser Glu Ser Ser Thr Tyr Thr Ala Ala Leu Pro Arg Glu Arg Leu 
            340                 345                 350         


Arg Pro Arg Pro Lys Val Phe Leu Cys Tyr Ser Ser Lys Asp Gly Gln 
        355                 360                 365             


Asn His Met Asn Val Val Gln Cys Phe Ala Tyr Phe Leu Gln Asp Phe 
    370                 375                 380                 


Cys Gly Cys Glu Val Ala Leu Asp Leu Trp Glu Asp Phe Ser Leu Cys 
385                 390                 395                 400 


Arg Glu Gly Gln Arg Glu Trp Val Ile Gln Lys Ile His Glu Ser Gln 
                405                 410                 415     


Phe Ile Ile Val Val Cys Ser Lys Gly Met Lys Tyr Phe Val Asp Lys 
            420                 425                 430         


Lys Asn Tyr Lys His Lys Gly Gly Gly Arg Gly Ser Gly Lys Gly Glu 
        435                 440                 445             


Leu Phe Leu Val Ala Val Ser Ala Ile Ala Glu Lys Leu Arg Gln Ala 
    450                 455                 460                 


Lys Gln Ser Ser Ser Ala Ala Leu Ser Lys Phe Ile Ala Val Tyr Phe 
465                 470                 475                 480 


Asp Tyr Ser Cys Glu Gly Asp Val Pro Gly Ile Leu Asp Leu Ser Thr 
                485                 490                 495     


Lys Tyr Arg Leu Met Asp Asn Leu Pro Gln Leu Cys Ser His Leu His 
            500                 505                 510         


Ser Arg Asp His Gly Leu Gln Glu Pro Gly Gln His Thr Arg Gln Gly 
        515                 520                 525             


Ser Arg Arg Asn Tyr Phe Arg Ser Lys Ser Gly Arg Ser Leu Tyr Val 
    530                 535                 540                 


Ala Ile Cys Asn Met His Gln Phe Ile Asp Glu Glu Pro Asp Trp Phe 
545                 550                 555                 560 


Glu Lys Gln Phe Val Pro Phe His Pro Pro Pro Leu Arg Tyr Arg Glu 
                565                 570                 575     


Pro Val Leu Glu Lys Phe Asp Ser Gly Leu Val Leu Asn Asp Val Met 
            580                 585                 590         


Cys Lys Pro Gly Pro Glu Ser Asp Phe Cys Leu Lys Val Glu Ala Ala 
        595                 600                 605             


Val Leu Gly Ala Thr Gly Pro Ala Asp Ser Gln His Glu Ser Gln His 
    610                 615                 620                 


Gly Gly Leu Asp Gln Asp Gly Glu Ala Arg Pro Ala Leu Asp Gly Ser 
625                 630                 635                 640 


Ala Ala Leu Gln Pro Leu Leu His Thr Val Lys Ala Gly Ser Pro Ser 
                645                 650                 655     


Asp Met Pro Arg Asp Ser Gly Ile Tyr Asp Ser Ser Val Pro Ser Ser 
            660                 665                 670         


Glu Leu Ser Leu Pro Leu Met Glu Gly Leu Ser Thr Asp Gln Thr Glu 
        675                 680                 685             


Thr Ser Ser Leu Thr Glu Ser Val Ser Ser Ser Ser Gly Leu Gly Glu 
    690                 695                 700                 


Glu Glu Pro Pro Ala Leu Pro Ser Lys Leu Leu Ser Ser Gly Ser Cys 
705                 710                 715                 720 


Lys Ala Asp Leu Gly Cys Arg Ser Tyr Thr Asp Glu Leu His Ala Val 
                725                 730                 735     


Ala Pro Leu 
            


<210>  25
<211>  8742
<212>  DNA
<213>  Homo sapiens

<400>  25
atccgctctt cttttcctcc gggaaaagaa acgggaagtg gccgtgggcc ggtgaattcc       60

gtgtagtggc caagctttgt tccaaagagg gggaggtggt gacagtctct tgcccactga      120

agcgtgccag acagagtgct aggcatgggg gcagaggtga atcagatgac agccacctct      180

caccacgagg agtggctgaa agtgtgactg gactacaggc aatcctggcc ttggcaggga      240

gtggggccag ccagcagaaa cagtgggctg tacaacatca ccttcaaata tgacaattgt      300

accacctact tgaatccagt ggggaagcat gtgattgctg acgcccagaa tatcaccatc      360

agccagtatg cttgccatga ccaagtggca gtcaccattc tttggtcccc aggggccctc      420

ggcatcgaat tcctgaaagg atttcgggta atactggagg agctgaagtc ggagggaaga      480

cagtgccaac aactgattct aaaggatccg aagcagctca acagtagctt caaaagaact      540

ggaatggaat ctcaaccttt cctgaatatg aaatttgaaa cggattattt cgtaaaggtt      600

gtcccttttc cttccattaa aaacgaaagc aattaccacc ctttcttctt tagaacccga      660

gcctgtgacc tgttgttaca gccggacaat ctagcttgta aacccttctg gaagcctcgg      720

aacctgaaca tcagccagca tggctcggac atgcaggtgt ccttcgacca tgcaccgcac      780

aacttcggct tccgtttctt ctatcttcac tacaagctca agcacgaagg acctttcaag      840

cgaaagacct gtaagcagga gcaaactaca gagacgacca gctgcctcct tcaaaatgtt      900

tctccagggg attatataat tgagctggtg gatgacacta acacaacaag aaaagtgatg      960

cattatgcct taaagccagt gcactccccg tgggccgggc ccatcagagc cgtggccatc     1020

acagtgccac tggtagtcat atcggcattc gcgacgctct tcactgtgat gtgccgcaag     1080

aagcaacaag aaaatatata ttcacattta gatgaagaga gctctgagtc ttccacatac     1140

actgcagcac tcccaagaga gaggctccgg ccgcggccga aggtctttct ctgctattcc     1200

agtaaagatg gccagaatca catgaatgtc gtccagtgtt tcgcctactt cctccaggac     1260

ttctgtggct gtgaggtggc tctggacctg tgggaagact tcagcctctg tagagaaggg     1320

cagagagaat gggtcatcca gaagatccac gagtcccagt tcatcattgt ggtttgttcc     1380

aaaggtatga agtactttgt ggacaagaag aactacaaac acaaaggagg tggccgaggc     1440

tcggggaaag gagagctctt cctggtggcg gtgtcagcca ttgccgaaaa gctccgccag     1500

gccaagcaga gttcgtccgc ggcgctcagc aagtttatcg ccgtctactt tgattattcc     1560

tgcgagggag acgtccccgg tatcctagac ctgagtacca agtacagact catggacaat     1620

cttcctcagc tctgttccca cttgcactcc cgagaccacg gcctccagga gccggggcag     1680

cacacgcgac agggcagcag aaggaactac ttccggagca agtcaggccg gtccctatac     1740

gtcgccattt gcaacatgca ccagtttatt gacgaggagc ccgactggtt cgaaaagcag     1800

ttcgttccct tccatcctcc tccactgcgc taccgggagc cagtcttgga gaaatttgat     1860

tcgggcttgg ttttaaatga tgtcatgtgc aaaccagggc ctgagagtga cttctgccta     1920

aaggtagagg cggctgttct tggggcaacc ggaccagccg actcccagca cgagagtcag     1980

catgggggcc tggaccaaga cggggaggcc cggcctgccc ttgacggtag cgccgccctg     2040

caacccctgc tgcacacggt gaaagccggc agcccctcgg acatgccgcg ggactcaggc     2100

atctatgact cgtctgtgcc ctcatccgag ctgtctctgc cactgatgga aggactctcg     2160

acggaccaga cagaaacgtc ttccctgacg gagagcgtgt cctcctcttc aggcctgggt     2220

gaggaggaac ctcctgccct tccttccaag ctcctctctt ctgggtcatg caaagcagat     2280

cttggttgcc gcagctacac tgatgaactc cacgcggtcg cccctttgta acaaaacgaa     2340

agagtctaag cattgccact ttagctgctg cctccctctg attccccagc tcatctccct     2400

ggttgcatgg cccacttgga gctgaggtct catacaagga tatttggagt gaaatgctgg     2460

ccagtacttg ttctcccttg ccccaaccct ttaccggata tcttgacaaa ctctccaatt     2520

ttctaaaatg atatggagct ctgaaaggca tgtccataag gtctgacaac agcttgccaa     2580

atttggttag tccttggatc agagcctgtt gtgggaggta gggaggaaat atgtaaagaa     2640

aaacaggaag atacctgcac taatcattca gacttcattg agctctgcaa actttgcctg     2700

tttgctattg gctaccttga tttgaaatgc tttgtgaaaa aaggcacttt taacatcata     2760

gccacagaaa tcaagtgcca gtctatctgg aatccatgtt gtattgcaga taatgttctc     2820

atttattttt gatgtagaat ttacattgcc atgggtgtta aataagcttt gagtcaaaag     2880

tcaagaaagt gactgaatat acagtcacct tttatgaaat gagtctctgt gttactgggt     2940

ggcatgactg attgaggtga agctcacggg gccaggctga ccgtcttgac cgttccactt     3000

gagataggtt ggtcatcgtg cagaaggccc caggacctca gcacacacag cctcctcttg     3060

gtctgagtag gcatcatgtg ggggccagat ctgcctgctg tttccatggg ttacatttac     3120

tgtgctgtat ctcagatgtt ggtgtctgga agtttattct taagagactg ctacccagct     3180

ggtctgtatt attggaagtt gcagttcgtg ctttggttgg ccttctggtc taaagctgtg     3240

tcctgaatat tagggatcac aattcactga aatacagcag tgtgtggagg tgatggccag     3300

ttaatctgct gaactggttt tgactaatga caaacctctt tttaagatgg tagaatggag     3360

gtgatagtca caaaagtaaa tgttccattt ttatgaatga ctttctacag agtttctatt     3420

tctaaagaaa aaacaattgt tcacatccca tctgatgatt agcatgtgtg taatgaatgc     3480

tgtcttggtc tcccctgtgg aaacccttct ccctgtgcct tagagcaggt gtgtacatct     3540

ctcactacct ttctcatggg tgctgttaga ttttggcacc cgttttctca gcattcagcc     3600

cagggaatgt ggttttcact tcttcgtcag ataagaccaa catgaagggg tatgttgaga     3660

aacatcctga ggcaaggtgg gaggtgggat ggggcaggac tttcccttcc aagcacatgc     3720

atggcaggtg gggaaagggg ggcttgcacc cctgctggaa agaaaaggtt tgtgtatatt     3780

tctgatgcaa atgtcatact cactgctctg taaaggcagc tggcagcttt ttgggaaaag     3840

aacgtgctcg tctgttctct ggcatcaagt ttcttgcagc tgctctgagg gagagacagt     3900

gagctgcaag actgcctccc cataacaaca ggcaactcag agaagagtca ttttatgttg     3960

ttcctatgga atctggaatg agtgcagagc tcctacccac acatgactgc cccgccattt     4020

catcctaggc attctgtgaa ggagattggt tagtccaaac ttgctaacat acgaaaattc     4080

acttggaaca tgatgagaga tttcttattg aggccaagag atgtttcctg tcccagagga     4140

accattagga gtcgctttta gggtattcag ctttgttcat gaaataaggc atctctgaga     4200

aagtggcccc agggagagaa tggaggactg ggaggagaag cattaactga gctccaaggg     4260

tgtgtgggca gagagcttgc tatgtgaact cactccttaa gaaaatggaa gagaaaaaga     4320

gagtgctagt taaaaaatcg ggatgtttta gtttggattt agggttttga tacttatgtt     4380

gaaatactaa tgtttctgat caataaaatc aaactcttaa tataccgagt aatgaaacca     4440

tagtgtgatt gcctcagaat aaattgagaa gtccaacttc ctagttttgt ttaattagtt     4500

tcactttttc tactctcccc agtatgctag aaatgggaat cgttgccctg cagattacgg     4560

caaaacatct gttttaagca aagctgcatt ttttgactca gaaattgtcc cagacggtgg     4620

atataagatg aaattcagaa aaacgttctg ccaagtcaca ggcttttaga tattatggaa     4680

acaagaaatg gaaaacagga tgatctccat gagaggcctt gatcctgaga gtaaaaggct     4740

tgtgtagata ggttagacaa cgtcctctag aaaagagacc agggataagt ccaggtttcc     4800

aggaaaacca agaagcctgc gggtagctga aggtagagtg ctagttgttc atcttaactt     4860

accaatgagc tacagaaagg acttagcatc tgatgtcatc agctttgcca ggagagtgat     4920

caaggaggtt aaagctcagg taaaggtgtg ccttctcaga gattggctac aagcaacaga     4980

gaccacctca acagagacca cctcaacaga ctcagcccag ccatacaagg tgccaaagct     5040

cctccagagg gctgtcttgg gcctttgagg caattgatct ccagaaagag tcagaagtca     5100

ttccagtcca ggcccaggta ttcagatggt gacccagcca gataatagta tcttgagcaa     5160

ataatagtat cttgagtgca aataagcagg aagactgtcc ttcaaaaaat gtggggttac     5220

atgattttca gagccttttt ttcagagttg agcatctttt cttttaaaag aaataagggg     5280

caagaggacc aattttattc cttgaggaaa aatgacacac ccttctccca aaagaaagaa     5340

aactctctgg ccccccaact tcaacactaa tttggctccc tgaagaagag agaaaatatt     5400

atttctgtct ttattgaaga gaaatgggca atgccaatgt gaaggttact agtctttttt     5460

attttctatt ggtgaagact actactgctc ttatttagca gatcttatac cttcagtggt     5520

caccagtata gcaggtgagg tataaggaaa acagcagtgt gatgataaat ggtaattaat     5580

atactttgtc tgtgtcagca atagggaatg gtggggactg tggcaaactg aagcgcccct     5640

gttccaccca cagtgggtaa ttttccagtc gactgtggcc atgaagtact tcctgatctt     5700

cccatttttc aagaaaagct gacaatctgg atttttatat gaaaaattct gattttaaaa     5760

aatattggca actaagttaa aattcaagtg aatttagacc cagcagaaga catggatgga     5820

cctgatttgg tccactgact accagtttgt taacctgtgc tttataagat ttgaaggaaa     5880

ggcattcatg gtaattacag acggtgccac cagaaaatgc tcttgctaaa tgcagccagt     5940

agttagattg cttctttctc cagtctcccc cgcaaagaaa tttgacgtga ttctgaatgc     6000

actggacatg tcttgattgc gtctttacat ttcacagtgt cttaaaagaa aggcaagcca     6060

gttgttaatt tcagaatcag atttatgctc tctcaattta aaaaatgctg ggaacaattt     6120

catttttttt tttttgagat ggagtcttgc tctgttgccc aggctggagt gcagtggcgt     6180

gatctcggct cactgcaagc tccacctccc gggttcacgc cattctcctg cctcagcctc     6240

ctgagtagct gggactacag gcgcccacca ccacgcctgg ctaatttttt tgtattttta     6300

gtagagacgg ggtttcactg tgttagccag gatgatctcg atctcctgac ctggtgatcc     6360

gcttgcctcg gcctcccaaa gtgctgggat tacaggcgtg agccactgcg cccggcctaa     6420

caatttcatt taaactccac aacctaaagg gctttgttta tagttttagc tcttggcata     6480

atttttttca ggtggtgtgc aattctgagc ataggccaag acatgattag gaaagcaggc     6540

agttgtagag agtaaggcaa ggaacctcct agcgtccatt agagccaggt atttgcatta     6600

tcttccgttt taagtggtct gtgaattgac tgtgttttgg aggtgtgaaa cagtatacag     6660

agaaaagctt ttcctgatac tgagatatca gttaggagtc caaatggggt gttgggtcat     6720

ccttgccata tcacctcctt tccaggctca gagtgaaaat agacaaaagg aaatctgact     6780

gcaagccagt ggctttgatt ccagtttcag agtttaggga ctaggagaga gtttagatta     6840

tctagcatat tctccccctg gtgtcagaca gggctgtgcc tgaattattc cagacatatg     6900

gctgtagatg gtattcttta ttttataaga aggagattct gtaacctacc ctgctgatca     6960

gatagttctt tgtatgtctt agagaaattc aagccagctt ccttttgttc ggcttgtagt     7020

ggagaaagaa cagctggtca ccttccatgt attcaaaaac cacagtgaag tcatccccct     7080

ggtgttttta tttcagtgat aaataattcc acccacttaa accattcttc atggctcttg     7140

ttttccaggg gcctaataat tttcactgct gtaatgtttc tcagcttcac acttagttta     7200

gttgcccaaa caatgttggt gccttactca cattggtgcc ttgtgaagac gaggctcagg     7260

atggggatta tggggaaatt cttgcacacc cagctcctct taccacttaa aaatataatg     7320

gcactttcac aaaatgatat gtcacctata ttcattgaga attatttgac tgccacattt     7380

ttcccctgat gatagtcatc tatcataact tgtgtttgtt ttcctcctga gatcaaacac     7440

ttggtgctta ttcctgatgt atactctgag accagctctt accttctgag tggcagctac     7500

ccctccctcc caattttaga tcctattttt acacatctct atagatatca cctttatttc     7560

atgactcaca atattaaatg gtacagactt cagtttaacc actggtgtgg taacagcagt     7620

agttgctaag taccaccttc ccattgctgt ttgagggcta atttgcaaag acatttgaat     7680

ctcccagtga agatgtctgg ggaattttgg ccagttgtct tccctcttgc ccttttgttc     7740

tttaaaattc agcttggacc atagacacct ccaggatctt gtttatgttc tgctctcaat     7800

tgaccaagca ctgcgttttg cacaatcaga agtctcacaa aagcaaacag ttatgactgc     7860

atatctgatg tttatatcct ataaaatttc aggaagattc agagtcaatc ttctatttgt     7920

acatgatgta gacaaaatta gctgctccaa ttgttagaca aaaaattgcc attggattac     7980

actaatgtgc tcatctgttg ttttaaaagt ttggtatcag gcggggcacg gtggctcacg     8040

cctgtaatcc cagcattttg ggaggccaag gtgggcggat cacctgaggt ccagagttca     8100

agaccagcct gaccaacatg gtgaaaccct gtctctacta aaaatacaaa attaatcagg     8160

cgtggttgtg tgtgcctgta atcccagcta ctcgagaggc tgaggcagga gaatcgcttg     8220

aatccgggag gcagaggttg cagtgagctg agatcacgcc attgcactct agcctgggca     8280

acaagagcga aactccgtct caacaacaac aacaaaaagt ttggtatgtt tctctcaaga     8340

aaaaagcatg gtgagtccag acagcagcaa aagcttttgt gaaaaccaat tgtgttcatc     8400

tagatagtaa gtaactccta tttttactgt taatttttta aaagagaatt tttccctgtg     8460

gaaactccct gttagtacgt cctaggggag aaagcctgtg gaatatggtg gttattgatg     8520

gcgttgcctt tgtttcatct ttgagtttgc cctttgtggg atctagtggg ataatgagca     8580

ctgacagaac tcttaacagc gtgctgtatt tttgacattg aaaatgttaa tgacttgatt     8640

tgtacataac tctgtaacta ggtgaaagta gatcacagct gacatttaca aaatgttttt     8700

gtaccttaga atttctgcat taaataaaat gttttgtttt aa                        8742


<210>  26
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Asp Tyr Arg Gln Ser Trp Pro Trp Gln Gly Val Gly Pro Ala Ser 
1               5                   10                  15      


Arg Asn Ser Gly Leu Tyr Asn Ile Thr Phe Lys Tyr Asp Asn Cys Thr 
            20                  25                  30          


Thr Tyr Leu Asn Pro Val Gly Lys His Val Ile Ala Asp Ala Gln Asn 
        35                  40                  45              


Ile Thr Ile Ser Gln Tyr Ala Cys His Asp Gln Val Ala Val Thr Ile 
    50                  55                  60                  


Leu Trp Ser Pro Gly Ala Leu Gly Ile Glu Phe Leu Lys Gly Phe Arg 
65                  70                  75                  80  


Val Ile Leu Glu Glu Leu Lys Ser Glu Gly Arg Gln Cys Gln Gln Leu 
                85                  90                  95      


Ile Leu Lys Asp Pro Lys Gln Leu Asn Ser Ser Phe Lys Arg Thr Gly 
            100                 105                 110         


Met Glu Ser Gln Pro Phe Leu Asn Met Lys Phe Glu Thr Asp Tyr Phe 
        115                 120                 125             


Val Lys Val Val Pro Phe Pro Ser Ile Lys Asn Glu Ser Asn Tyr His 
    130                 135                 140                 


Pro Phe Phe Phe Arg Thr Arg Ala Cys Asp Leu Leu Leu Gln Pro Asp 
145                 150                 155                 160 


Asn Leu Ala Cys Lys Pro Phe Trp Lys Pro Arg Asn Leu Asn Ile Ser 
                165                 170                 175     


Gln His Gly Ser Asp Met Gln Val Ser Phe Asp His Ala Pro His Asn 
            180                 185                 190         


Phe Gly Phe Arg Phe Phe Tyr Leu His Tyr Lys Leu Lys His Glu Gly 
        195                 200                 205             


Pro Phe Lys Arg Lys Thr Cys Lys Gln Glu Gln Thr Thr Glu Thr Thr 
    210                 215                 220                 


Ser Cys Leu Leu Gln Asn Val Ser Pro Gly Asp Tyr Ile Ile Glu Leu 
225                 230                 235                 240 


Val Asp Asp Thr Asn Thr Thr Arg Lys Val Met His Tyr Ala Leu Lys 
                245                 250                 255     


Pro Val His Ser Pro Trp Ala Gly Pro Ile Arg Ala Val Ala Ile Thr 
            260                 265                 270         


Val Pro Leu Val Val Ile Ser Ala Phe Ala Thr Leu Phe Thr Val Met 
        275                 280                 285             


Cys Arg Lys Lys Gln Gln Glu Asn Ile Tyr Ser His Leu Asp Glu Glu 
    290                 295                 300                 


Ser Ser Glu Ser Ser Thr Tyr Thr Ala Ala Leu Pro Arg Glu Arg Leu 
305                 310                 315                 320 


Arg Pro Arg Pro Lys Val Phe Leu Cys Tyr Ser Ser Lys Asp Gly Gln 
                325                 330                 335     


Asn His Met Asn Val Val Gln Cys Phe Ala Tyr Phe Leu Gln Asp Phe 
            340                 345                 350         


Cys Gly Cys Glu Val Ala Leu Asp Leu Trp Glu Asp Phe Ser Leu Cys 
        355                 360                 365             


Arg Glu Gly Gln Arg Glu Trp Val Ile Gln Lys Ile His Glu Ser Gln 
    370                 375                 380                 


Phe Ile Ile Val Val Cys Ser Lys Gly Met Lys Tyr Phe Val Asp Lys 
385                 390                 395                 400 


Lys Asn Tyr Lys His Lys Gly Gly Gly Arg Gly Ser Gly Lys Gly Glu 
                405                 410                 415     


Leu Phe Leu Val Ala Val Ser Ala Ile Ala Glu Lys Leu Arg Gln Ala 
            420                 425                 430         


Lys Gln Ser Ser Ser Ala Ala Leu Ser Lys Phe Ile Ala Val Tyr Phe 
        435                 440                 445             


Asp Tyr Ser Cys Glu Gly Asp Val Pro Gly Ile Leu Asp Leu Ser Thr 
    450                 455                 460                 


Lys Tyr Arg Leu Met Asp Asn Leu Pro Gln Leu Cys Ser His Leu His 
465                 470                 475                 480 


Ser Arg Asp His Gly Leu Gln Glu Pro Gly Gln His Thr Arg Gln Gly 
                485                 490                 495     


Ser Arg Arg Asn Tyr Phe Arg Ser Lys Ser Gly Arg Ser Leu Tyr Val 
            500                 505                 510         


Ala Ile Cys Asn Met His Gln Phe Ile Asp Glu Glu Pro Asp Trp Phe 
        515                 520                 525             


Glu Lys Gln Phe Val Pro Phe His Pro Pro Pro Leu Arg Tyr Arg Glu 
    530                 535                 540                 


Pro Val Leu Glu Lys Phe Asp Ser Gly Leu Val Leu Asn Asp Val Met 
545                 550                 555                 560 


Cys Lys Pro Gly Pro Glu Ser Asp Phe Cys Leu Lys Val Glu Ala Ala 
                565                 570                 575     


Val Leu Gly Ala Thr Gly Pro Ala Asp Ser Gln His Glu Ser Gln His 
            580                 585                 590         


Gly Gly Leu Asp Gln Asp Gly Glu Ala Arg Pro Ala Leu Asp Gly Ser 
        595                 600                 605             


Ala Ala Leu Gln Pro Leu Leu His Thr Val Lys Ala Gly Ser Pro Ser 
    610                 615                 620                 


Asp Met Pro Arg Asp Ser Gly Ile Tyr Asp Ser Ser Val Pro Ser Ser 
625                 630                 635                 640 


Glu Leu Ser Leu Pro Leu Met Glu Gly Leu Ser Thr Asp Gln Thr Glu 
                645                 650                 655     


Thr Ser Ser Leu Thr Glu Ser Val Ser Ser Ser Ser Gly Leu Gly Glu 
            660                 665                 670         


Glu Glu Pro Pro Ala Leu Pro Ser Lys Leu Leu Ser Ser Gly Ser Cys 
        675                 680                 685             


Lys Ala Asp Leu Gly Cys Arg Ser Tyr Thr Asp Glu Leu His Ala Val 
    690                 695                 700                 


Ala Pro Leu 
705         


<210>  27
<211>  2717
<212>  DNA
<213>  Homo sapiens

<400>  27
cgagggctcc tgctggtact gtgttcgctg ctgcacagca aggccctgcc acccaccttc       60

aggccatgca gccatgttcc gggagcccta attgcacaga agcccatggg gagctccaga      120

ctggcagccc tgctcctgcc tctcctcctc atagtcatcg acctctctga ctctgctggg      180

attggctttc gccacctgcc ccactggaac acccgctgtc ctctggcctc ccacacggat      240

gacagtttca ctggaagttc tgcctatatc ccttgccgca cctggtgggc cctcttctcc      300

acaaagcctt ggtgtgtgcg agtctggcac tgttcccgct gtttgtgcca gcatctgctg      360

tcaggtggct caggtcttca acggggcctc ttccacctcc tggtgcagaa atccaaaaag      420

tcttccacat tcaagttcta taggagacac aagatgccag cacctgctca gaggaagctg      480

ctgcctcgtc gtcacctgtc tgagaagagc catcacattt ccatcccctc cccagacatc      540

tcccacaagg gacttcgctc taaaaggacc caaccttcgg atccagagac atgggaaagt      600

cttcccagat tggactcaca aaggcatgga ggacccgagt tctcctttga tttgctgcct      660

gaggcccggg ctattcgggt gaccatatct tcaggccctg aggtcagcgt gcgtctttgt      720

caccagtggg cactggagtg tgaagagctg agcagtccct atgatgtcca gaaaattgtg      780

tctgggggcc acactgtaga gctgccttat gaattccttc tgccctgtct gtgcatagag      840

gcatcctacc tgcaagagga cactgtgagg cgcaaaaaat gtcccttcca gagctggcca      900

gaagcctatg gctcggactt ctggaagtca gtgcacttca ctgactacag ccagcacact      960

cagatggtca tggccctgac actccgctgc ccactgaagc tggaagctgc cctctgccag     1020

aggcacgact ggcataccct ttgcaaagac ctcccgaatg ccacagctcg agagtcagat     1080

gggtggtatg ttttggagaa ggtggacctg cacccccagc tctgcttcaa gttctctttt     1140

ggaaacagca gccatgttga atgcccccac cagactgggt ctctcacatc ctggaatgta     1200

agcatggata cccaagccca gcagctgatt cttcacttct cctcaagaat gcatgccacc     1260

ttcagtgctg cctggagcct cccaggcttg gggcaggaca ctttggtgcc ccccgtgtac     1320

actgtcagcc aggcccgggg ctcaagccca gtgtcactag acctcatcat tcccttcctg     1380

aggccagggt gctgtgtcct ggtgtggcgg tcagatgtcc agtttgcctg gaagcacctc     1440

ttgtgtccgg atgtctctta cagacacctg gggctcttga tcctggcact gctggccctc     1500

ctcaccctac tgggtgttgt tctggccctc acctgccggc gcccacagtc aggcccgggc     1560

ccagcgcggc cagtgctcct cctgcacgcg gcggactcgg aggcgcagcg gcgcctggtg     1620

ggagcgctgg ctgaactgct acgggcagcg ctgggcggcg ggcgcgacgt gatcgtggac     1680

ctgtgggagg ggaggcacgt ggcgcgcgtg ggcccgctgc cgtggctctg ggcggcgcgg     1740

acgcgcgtag cgcgggagca gggcactgtg ctgctgctgt ggagcggcgc cgaccttcgc     1800

ccggtcagcg gccccgaccc ccgcgccgcg cccctgctcg ccctgctcca cgctgccccg     1860

cgcccgctgc tgctgctcgc ttacttcagt cgcctctgcg ccaagggcga catccccccg     1920

ccgctgcgcg ccctgccgcg ctaccgcctg ctgcgcgacc tgccgcgtct gctgcgggcg     1980

ctggacgcgc ggcctttcgc agaggccacc agctggggcc gccttggggc gcggcagcgc     2040

aggcagagcc gcctagagct gtgcagccgg ctcgaacgag aggccgcccg acttgcagac     2100

ctaggttgag cagagctcca ccgcagtccc gggtgtctgc ggccgcaacg caacggacac     2160

tggctggaac cccggaatga gccttcgacc ctgaaatcct tggggtgcct cgaggacgac     2220

tggccgaaaa gccgcattcc ctgcctcaca ggccggaagt cccagcccag tccccgcgcg     2280

cgtccctctt cctcctcata ctttcccttg actgagagct cctctaaccc ctgttctgat     2340

gggggagggc ggtcttccca cttcctctcc agaactccag aaagagcagt gtgcttatgc     2400

ttcagtccag gctggagagg ttggggccgg ggtagggagg caggagccat gtcagttctg     2460

aaggagggtg aggcggtggg ggattgcagg gggcggctga gagaaaacct ccttgggggc     2520

cagggattcc ctttcccact ctgaggctct ggccagaggg agagaggact ctggacctag     2580

gaaaagaggc ttttggctcc aggtggtcag gacagtgggg gttgggggtg gggtgggtgg     2640

gtgctggcgg tggggaccaa gatccggaaa gatgaataaa gacaaacatg acaaactaag     2700

aaaaaaaaaa aaaaaaa                                                    2717


<210>  28
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile 
1               5                   10                  15      


Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro 
            20                  25                  30          


His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp Ser Phe 
        35                  40                  45              


Thr Gly Ser Ser Ala Tyr Ile Pro Cys Arg Thr Trp Trp Ala Leu Phe 
    50                  55                  60                  


Ser Thr Lys Pro Trp Cys Val Arg Val Trp His Cys Ser Arg Cys Leu 
65                  70                  75                  80  


Cys Gln His Leu Leu Ser Gly Gly Ser Gly Leu Gln Arg Gly Leu Phe 
                85                  90                  95      


His Leu Leu Val Gln Lys Ser Lys Lys Ser Ser Thr Phe Lys Phe Tyr 
            100                 105                 110         


Arg Arg His Lys Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro Arg 
        115                 120                 125             


Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser Pro Asp 
    130                 135                 140                 


Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser Asp Pro 
145                 150                 155                 160 


Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg His Gly Gly 
                165                 170                 175     


Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile Arg Val 
            180                 185                 190         


Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys His Gln Trp 
        195                 200                 205             


Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln Lys Ile 
    210                 215                 220                 


Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe Leu Leu Pro 
225                 230                 235                 240 


Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val Arg Arg 
                245                 250                 255     


Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser Asp Phe 
            260                 265                 270         


Trp Lys Ser Val His Phe Thr Asp Tyr Ser Gln His Thr Gln Met Val 
        275                 280                 285             


Met Ala Leu Thr Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala Leu Cys 
    290                 295                 300                 


Gln Arg His Asp Trp His Thr Leu Cys Lys Asp Leu Pro Asn Ala Thr 
305                 310                 315                 320 


Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu Glu Lys Val Asp Leu His 
                325                 330                 335     


Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly Asn Ser Ser His Val Glu 
            340                 345                 350         


Cys Pro His Gln Thr Gly Ser Leu Thr Ser Trp Asn Val Ser Met Asp 
        355                 360                 365             


Thr Gln Ala Gln Gln Leu Ile Leu His Phe Ser Ser Arg Met His Ala 
    370                 375                 380                 


Thr Phe Ser Ala Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp Thr Leu 
385                 390                 395                 400 


Val Pro Pro Val Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser Pro Val 
                405                 410                 415     


Ser Leu Asp Leu Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys Val Leu 
            420                 425                 430         


Val Trp Arg Ser Asp Val Gln Phe Ala Trp Lys His Leu Leu Cys Pro 
        435                 440                 445             


Asp Val Ser Tyr Arg His Leu Gly Leu Leu Ile Leu Ala Leu Leu Ala 
    450                 455                 460                 


Leu Leu Thr Leu Leu Gly Val Val Leu Ala Leu Thr Cys Arg Arg Pro 
465                 470                 475                 480 


Gln Ser Gly Pro Gly Pro Ala Arg Pro Val Leu Leu Leu His Ala Ala 
                485                 490                 495     


Asp Ser Glu Ala Gln Arg Arg Leu Val Gly Ala Leu Ala Glu Leu Leu 
            500                 505                 510         


Arg Ala Ala Leu Gly Gly Gly Arg Asp Val Ile Val Asp Leu Trp Glu 
        515                 520                 525             


Gly Arg His Val Ala Arg Val Gly Pro Leu Pro Trp Leu Trp Ala Ala 
    530                 535                 540                 


Arg Thr Arg Val Ala Arg Glu Gln Gly Thr Val Leu Leu Leu Trp Ser 
545                 550                 555                 560 


Gly Ala Asp Leu Arg Pro Ser Gly Pro Asp Pro Arg Ala Ala Pro Leu 
                565                 570                 575     


Leu Ala Leu Leu His Ala Ala Pro Arg Pro Leu Leu Leu Leu Ala Tyr 
            580                 585                 590         


Phe Ser Arg Leu Cys Ala Lys Gly Asp Ile Pro Pro Pro Leu Arg Ala 
        595                 600                 605             


Leu Pro Arg Tyr Arg Leu Leu Arg Asp Leu Pro Arg Leu Leu Arg Ala 
    610                 615                 620                 


Leu Asp Ala Arg Pro Phe Ala Glu Ala Thr Ser Trp Gly Arg Leu Gly 
625                 630                 635                 640 


Ala Arg Gln Arg Arg Gln Ser Arg Leu Glu Leu Cys Ser Arg Leu Glu 
                645                 650                 655     


Arg Glu Ala Ala Arg Leu Ala Asp Leu Gly 
            660                 665     


<210>  29
<211>  2581
<212>  DNA
<213>  Homo sapiens

<400>  29
cgagggctcc tgctggtact gtgttcgctg ctgcacagca aggccctgcc acccaccttc       60

aggccatgca gccatgttcc gggagcccta attgcacaga agcccatggg gagctccaga      120

ctggcagccc tgctcctgcc tctcctcctc atagtcatcg acctctctga ctctgctggg      180

attggctttc gccacctgcc ccactggaac acccgctgtc ctctggcctc ccacacggtc      240

ttcaacgggg cctcttccac ctcctggtgc agaaatccaa aaagtcttcc acattcaagt      300

tctataggag acacaagatg ccagcacctg ctcagaggaa gctgctgcct cgtcgtcacc      360

tgtctgagaa gagccatcac atttccatcc cctccccaga catctcccac aagggacttc      420

gctctaaaag gacccaacct tcggatccag agacatggga aagtcttccc agattggact      480

cacaaaggca tggaggaccc gagttctcct ttgatttgct gcctgaggcc cgggctattc      540

gggtgaccat atcttcaggc cctgaggtca gcgtgcgtct ttgtcaccag tgggcactgg      600

agtgtgaaga gctgagcagt ccctatgatg tccagaaaat tgtgtctggg ggccacactg      660

tagagctgcc ttatgaattc cttctgccct gtctgtgcat agaggcatcc tacctgcaag      720

aggacactgt gaggcgcaaa aaatgtccct tccagagctg gccagaagcc tatggctcgg      780

acttctggaa gtcagtgcac ttcactgact acagccagca cactcagatg gtcatggccc      840

tgacactccg ctgcccactg aagctggaag ctgccctctg ccagaggcac gactggcata      900

ccctttgcaa agacctcccg aatgccacag ctcgagagtc agatgggtgg tatgttttgg      960

agaaggtgga cctgcacccc cagctctgct tcaagttctc ttttggaaac agcagccatg     1020

ttgaatgccc ccaccagact gggtctctca catcctggaa tgtaagcatg gatacccaag     1080

cccagcagct gattcttcac ttctcctcaa gaatgcatgc caccttcagt gctgcctgga     1140

gcctcccagg cttggggcag gacactttgg tgccccccgt gtacactgtc agccaggccc     1200

ggggctcaag cccagtgtca ctagacctca tcattccctt cctgaggcca gggtgctgtg     1260

tcctggtgtg gcggtcagat gtccagtttg cctggaagca cctcttgtgt ccggatgtct     1320

cttacagaca cctggggctc ttgatcctgg cactgctggc cctcctcacc ctactgggtg     1380

ttgttctggc cctcacctgc cggcgcccac agtcaggccc gggcccagcg cggccagtgc     1440

tcctcctgca cgcggcggac tcggaggcgc agcggcgcct ggtgggagcg ctggctgaac     1500

tgctacgggc agcgctgggc ggcgggcgcg acgtgatcgt ggacctgtgg gaggggaggc     1560

acgtggcgcg cgtgggcccg ctgccgtggc tctgggcggc gcggacgcgc gtagcgcggg     1620

agcagggcac tgtgctgctg ctgtggagcg gcgccgacct tcgcccggtc agcggccccg     1680

acccccgcgc cgcgcccctg ctcgccctgc tccacgctgc cccgcgcccg ctgctgctgc     1740

tcgcttactt cagtcgcctc tgcgccaagg gcgacatccc cccgccgctg cgcgccctgc     1800

cgcgctaccg cctgctgcgc gacctgccgc gtctgctgcg ggcgctggac gcgcggcctt     1860

tcgcagaggc caccagctgg ggccgccttg gggcgcggca gcgcaggcag agccgcctag     1920

agctgtgcag ccggctcgaa cgagaggccg cccgacttgc agacctaggt tgagcagagc     1980

tccaccgcag tcccgggtgt ctgcggccgc aacgcaacgg acactggctg gaaccccgga     2040

atgagccttc gaccctgaaa tccttggggt gcctcgagga cgactggccg aaaagccgca     2100

ttccctgcct cacaggccgg aagtcccagc ccagtccccg cgcgcgtccc tcttcctcct     2160

catactttcc cttgactgag agctcctcta acccctgttc tgatggggga gggcggtctt     2220

cccacttcct ctccagaact ccagaaagag cagtgtgctt atgcttcagt ccaggctgga     2280

gaggttgggg ccggggtagg gaggcaggag ccatgtcagt tctgaaggag ggtgaggcgg     2340

tgggggattg cagggggcgg ctgagagaaa acctccttgg gggccaggga ttccctttcc     2400

cactctgagg ctctggccag agggagagag gactctggac ctaggaaaag aggcttttgg     2460

ctccaggtgg tcaggacagt gggggttggg ggtggggtgg gtgggtgctg gcggtgggga     2520

ccaagatccg gaaagatgaa taaagacaaa catgacaaac taagaaaaaa aaaaaaaaaa     2580

a                                                                     2581


<210>  30
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro Arg Arg His Leu Ser 
1               5                   10                  15      


Glu Lys Ser His His Ile Ser Ile Pro Ser Pro Asp Ile Ser His Lys 
            20                  25                  30          


Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser Asp Pro Glu Thr Trp Glu 
        35                  40                  45              


Ser Leu Pro Arg Leu Asp Ser Gln Arg His Gly Gly Pro Glu Phe Ser 
    50                  55                  60                  


Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile Arg Val Thr Ile Ser Ser 
65                  70                  75                  80  


Gly Pro Glu Val Ser Val Arg Leu Cys His Gln Trp Ala Leu Glu Cys 
                85                  90                  95      


Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln Lys Ile Val Ser Gly Gly 
            100                 105                 110         


His Thr Val Glu Leu Pro Tyr Glu Phe Leu Leu Pro Cys Leu Cys Ile 
        115                 120                 125             


Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val Arg Arg Lys Lys Cys Pro 
    130                 135                 140                 


Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser Asp Phe Trp Lys Ser Val 
145                 150                 155                 160 


His Phe Thr Asp Tyr Ser Gln His Thr Gln Met Val Met Ala Leu Thr 
                165                 170                 175     


Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala Leu Cys Gln Arg His Asp 
            180                 185                 190         


Trp His Thr Leu Cys Lys Asp Leu Pro Asn Ala Thr Ala Arg Glu Ser 
        195                 200                 205             


Asp Gly Trp Tyr Val Leu Glu Lys Val Asp Leu His Pro Gln Leu Cys 
    210                 215                 220                 


Phe Lys Phe Ser Phe Gly Asn Ser Ser His Val Glu Cys Pro His Gln 
225                 230                 235                 240 


Thr Gly Ser Leu Thr Ser Trp Asn Val Ser Met Asp Thr Gln Ala Gln 
                245                 250                 255     


Gln Leu Ile Leu His Phe Ser Ser Arg Met His Ala Thr Phe Ser Ala 
            260                 265                 270         


Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp Thr Leu Val Pro Pro Val 
        275                 280                 285             


Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser Pro Val Ser Leu Asp Leu 
    290                 295                 300                 


Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys Val Leu Val Trp Arg Ser 
305                 310                 315                 320 


Asp Val Gln Phe Ala Trp Lys His Leu Leu Cys Pro Asp Val Ser Tyr 
                325                 330                 335     


Arg His Leu Gly Leu Leu Ile Leu Ala Leu Leu Ala Leu Leu Thr Leu 
            340                 345                 350         


Leu Gly Val Val Leu Ala Leu Thr Cys Arg Arg Pro Gln Ser Gly Pro 
        355                 360                 365             


Gly Pro Ala Arg Pro Val Leu Leu Leu His Ala Ala Asp Ser Glu Ala 
    370                 375                 380                 


Gln Arg Arg Leu Val Gly Ala Leu Ala Glu Leu Leu Arg Ala Ala Leu 
385                 390                 395                 400 


Gly Gly Gly Arg Asp Val Ile Val Asp Leu Trp Glu Gly Arg His Val 
                405                 410                 415     


Ala Arg Val Gly Pro Leu Pro Trp Leu Trp Ala Ala Arg Thr Arg Val 
            420                 425                 430         


Ala Arg Glu Gln Gly Thr Val Leu Leu Leu Trp Ser Gly Ala Asp Leu 
        435                 440                 445             


Arg Pro Val Ser Gly Pro Asp Pro Arg Ala Ala Pro Leu Leu Ala Leu 
    450                 455                 460                 


Leu His Ala Ala Pro Arg Pro Leu Leu Leu Leu Ala Tyr Phe Ser Arg 
465                 470                 475                 480 


Leu Cys Ala Lys Gly Asp Ile Pro Pro Pro Leu Arg Ala Leu Pro Arg 
                485                 490                 495     


Tyr Arg Leu Leu Arg Asp Leu Pro Arg Leu Leu Arg Ala Leu Asp Ala 
            500                 505                 510         


Arg Pro Phe Ala Glu Ala Thr Ser Trp Gly Arg Leu Gly Ala Arg Gln 
        515                 520                 525             


Arg Arg Gln Ser Arg Leu Glu Leu Cys Ser Arg Leu Glu Arg Glu Ala 
    530                 535                 540                 


Ala Arg Leu Ala Asp Leu Gly 
545                 550     


<210>  31
<211>  2729
<212>  DNA
<213>  Homo sapiens

<400>  31
ggtgcgtccc ccaacctgat gctagcccct ttcctgttac ttctcaccca cagcaggagc       60

cccttgtctt tcaggccatg cagccatgtt ccgggagccc taattgcaca gaagcccatg      120

gggagctcca gactggcagc cctgctcctg cctctcctcc tcatagtcat cgacctctct      180

gactctgctg ggattggctt tcgccacctg ccccactgga acacccgctg tcctctggcc      240

tcccacacgg atgacagttt cactggaagt tctgcctata tcccttgccg cacctggtgg      300

gccctcttct ccacaaagcc ttggtgtgtg cgagtctggc actgttcccg ctgtttgtgc      360

cagcatctgc tgtcaggtgg ctcaggtctt caacggggcc tcttccacct cctggtgcag      420

aaatccaaaa agtcttccac attcaagttc tataggagac acaagatgcc agcacctgct      480

cagaggaagc tgctgcctcg tcgtcacctg tctgagaaga gccatcacat ttccatcccc      540

tccccagaca tctcccacaa gggacttcgc tctaaaagga cccaaccttc ggatccagag      600

acatgggaaa gtcttcccag attggactca caaaggcatg gaggacccga gttctccttt      660

gatttgctgc ctgaggcccg ggctattcgg gtgaccatat cttcaggccc tgaggtcagc      720

gtgcgtcttt gtcaccagtg ggcactggag tgtgaagagc tgagcagtcc ctatgatgtc      780

cagaaaattg tgtctggggg ccacactgta gagctgcctt atgaattcct tctgccctgt      840

ctgtgcatag aggcatccta cctgcaagag gacactgtga ggcgcaaaaa atgtcccttc      900

cagagctggc cagaagccta tggctcggac ttctggaagt cagtgcactt cactgactac      960

agccagcaca ctcagatggt catggccctg acactccgct gcccactgaa gctggaagct     1020

gccctctgcc agaggcacga ctggcatacc ctttgcaaag acctcccgaa tgccacagct     1080

cgagagtcag atgggtggta tgttttggag aaggtggacc tgcaccccca gctctgcttc     1140

aagttctctt ttggaaacag cagccatgtt gaatgccccc accagactgg gtctctcaca     1200

tcctggaatg taagcatgga tacccaagcc cagcagctga ttcttcactt ctcctcaaga     1260

atgcatgcca ccttcagtgc tgcctggagc ctcccaggct tggggcagga cactttggtg     1320

ccccccgtgt acactgtcag ccaggcccgg ggctcaagcc cagtgtcact agacctcatc     1380

attcccttcc tgaggccagg gtgctgtgtc ctggtgtggc ggtcagatgt ccagtttgcc     1440

tggaagcacc tcttgtgtcc ggatgtctct tacagacacc tggggctctt gatcctggca     1500

ctgctggccc tcctcaccct actgggtgtt gttctggccc tcacctgccg gcgcccacag     1560

tcaggcccgg gcccagcgcg gccagtgctc ctcctgcacg cggcggactc ggaggcgcag     1620

cggcgcctgg tgggagcgct ggctgaactg ctacgggcag cgctgggcgg cgggcgcgac     1680

gtgatcgtgg acctgtggga ggggaggcac gtggcgcgcg tgggcccgct gccgtggctc     1740

tgggcggcgc ggacgcgcgt agcgcgggag cagggcactg tgctgctgct gtggagcggc     1800

gccgaccttc gcccggtcag cggccccgac ccccgcgccg cgcccctgct cgccctgctc     1860

cacgctgccc cgcgcccgct gctgctgctc gcttacttca gtcgcctctg cgccaagggc     1920

gacatccccc cgccgctgcg cgccctgccg cgctaccgcc tgctgcgcga cctgccgcgt     1980

ctgctgcggg cgctggacgc gcggcctttc gcagaggcca ccagctgggg ccgccttggg     2040

gcgcggcagc gcaggcagag ccgcctagag ctgtgcagcc ggctcgaacg agaggccgcc     2100

cgacttgcag acctaggttg agcagagctc caccgcagtc ccgggtgtct gcggccgcaa     2160

cgcaacggac actggctgga accccggaat gagccttcga ccctgaaatc cttggggtgc     2220

ctcgaggacg actggccgaa aagccgcatt ccctgcctca caggccggaa gtcccagccc     2280

agtccccgcg cgcgtccctc ttcctcctca tactttccct tgactgagag ctcctctaac     2340

ccctgttctg atgggggagg gcggtcttcc cacttcctct ccagaactcc agaaagagca     2400

gtgtgcttat gcttcagtcc aggctggaga ggttggggcc ggggtaggga ggcaggagcc     2460

atgtcagttc tgaaggaggg tgaggcggtg ggggattgca gggggcggct gagagaaaac     2520

ctccttgggg gccagggatt ccctttccca ctctgaggct ctggccagag ggagagagga     2580

ctctggacct aggaaaagag gcttttggct ccaggtggtc aggacagtgg gggttggggg     2640

tggggtgggt gggtgctggc ggtggggacc aagatccgga aagatgaata aagacaaaca     2700

tgacaaacta agaaaaaaaa aaaaaaaaa                                       2729


<210>  32
<211>  667
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile 
1               5                   10                  15      


Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro 
            20                  25                  30          


His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp Ser Phe 
        35                  40                  45              


Thr Gly Ser Ser Ala Tyr Ile Pro Cys Arg Thr Trp Trp Ala Leu Phe 
    50                  55                  60                  


Ser Thr Lys Pro Trp Cys Val Arg Val Trp His Cys Ser Arg Cys Leu 
65                  70                  75                  80  


Cys Gln His Leu Leu Ser Gly Gly Ser Gly Leu Gln Arg Gly Leu Phe 
                85                  90                  95      


His Leu Leu Val Gln Lys Ser Lys Lys Ser Ser Thr Phe Lys Phe Tyr 
            100                 105                 110         


Arg Arg His Lys Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro Arg 
        115                 120                 125             


Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser Pro Asp 
    130                 135                 140                 


Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser Asp Pro 
145                 150                 155                 160 


Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg His Gly Gly 
                165                 170                 175     


Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile Arg Val 
            180                 185                 190         


Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys His Gln Trp 
        195                 200                 205             


Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln Lys Ile 
    210                 215                 220                 


Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe Leu Leu Pro 
225                 230                 235                 240 


Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val Arg Arg 
                245                 250                 255     


Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser Asp Phe 
            260                 265                 270         


Trp Lys Ser Val His Phe Thr Asp Tyr Ser Gln His Thr Gln Met Val 
        275                 280                 285             


Met Ala Leu Thr Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala Leu Cys 
    290                 295                 300                 


Gln Arg His Asp Trp His Thr Leu Cys Lys Asp Leu Pro Asn Ala Thr 
305                 310                 315                 320 


Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu Glu Lys Val Asp Leu His 
                325                 330                 335     


Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly Asn Ser Ser His Val Glu 
            340                 345                 350   