                         SEQUENCE LISTING

<110>  Johnson, Leslie S.
       Huang, Ling S.
 
<120>  Improved Compositions for the Prevention and Treatment of 
       Smallpox

<130>  1301.0011I2

<150>  61015106
<151>  2007-12-19

<160>  44    

<170>  PatentIn version 3.4

<210>  1
<211>  336
<212>  DNA
<213>  Mus sp.

<400>  1
gacatggtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcagt     60

atgagctgca aatccagtca gactctgctc aacagtagaa cccgaaagaa ctacttggct    120

tggtaccagc agaaaccagg gcagtctcct aaactactga tctactgggc atccactagg    180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc    240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctg    300

tggacgttcg gtggaggcac caagctggaa atcaaa                              336


<210>  2
<211>  112
<212>  PRT
<213>  Mus sp.

<400>  2

Asp Met Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Ser Met Ser Cys Lys Ser Ser Gln Thr Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  3
<211>  357
<212>  DNA
<213>  Mus sp.

<400>  3
caggtccagc ttcagcagtc tggggctgaa ctggcaaaac ctggggcctc agtgaagatg     60

tcctgcaagg cttctggcta cacctttact aggtactgga tgcactgggt aaaacagagg    120

cctggacagg gtctggaatg gattggatac attaatccta gcactggtta tactgagtac    180

aatcagaaat tcaaggacaa ggccacattg actgcggaca aatcctccag cacagtctac    240

atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagaactaca    300

gtggatggtt acgactttgc ttactggggc caagggactc tggtcactgt ctcggca       357


<210>  4
<211>  119
<212>  PRT
<213>  Mus sp.

<400>  4

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Thr Val Asp Gly Tyr Asp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  5
<211>  336
<212>  DNA
<213>  artificial

<220>
<223>  humanized murine 7D11 antibody light chain variable region

<400>  5
gacatcgtga tgacccaatc tccagactct ttggctgtgt ctctagggga gagggccacc     60

atcaactgca aatccagtca gactctgctc aacagtagaa cccgaaagaa ctacttggct    120

tggtaccaac agaaaccagg acagccaccc aaactcctca tctactgggc atccactagg    180

gaatctgggg tcccagacag gtttagtggc agtgggtctg ggacagactt caccctcacc    240

atcagcagcc tgcaggctga ggatgtggca gtttattact gcaagcaatc ttataatctg    300

tggacgttcg gacaagggac caagcttgag atcaaa                              336


<210>  6
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  humanized 7D11 murine antibody light chain variable region

<400>  6

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Thr Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  7
<211>  658
<212>  DNA
<213>  artificial

<220>
<223>  humanized murine antibody 7D11 light chain

<400>  7
gacatcgtga tgacccaatc tccagactct ttggctgtgt ctctagggga gagggccacc     60

atcaactgca aatccagtca gactctgctc aacagtagaa cccgaaagaa ctacttggct    120

tggtaccaac agaaaccagg acagccaccc aaactcctca tctactgggc atccactagg    180

gaatctgggg tcccagacag gtttagtggc agtgggtctg ggacagactt caccctcacc    240

atcagcagcc tgcaggctga ggatgtggca gtttattact gcaagcaatc ttataatctg    300

tggacgttcg gacaagggac caagcttgag atcaaagtcc tcggtcagcc caaggccaac    360

cccacagtca ccctgttccc gccctcctct gaggagcttc aagccaacaa ggccacactg    420

gtgtgtctca taagtgactt ctacccggga gccgtgacag tggcctggaa ggcagatggc    480

agccccgtca aggcgggagt ggagaccacc acaccctcca aacaaagcaa caacaagtac    540

gcggccagca gctacctgag cctgacgccc gagcagtgga agtcccacag aagctacagc    600

tgccaggtca cgcatgaagg gagcaccgtg gagaagacag tggcccctac agaatgtt      658


<210>  8
<211>  204
<212>  PRT
<213>  artificial

<220>
<223>  humanized murine antibody 7D11 light chain

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Thr Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Ala Ser Thr Arg Glu Ser Gly 
        35                  40                  45              


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    50                  55                  60                  


Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys 
65                  70                  75                  80  


Gln Ser Tyr Asn Leu Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
                85                  90                  95      


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
            100                 105                 110         


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
        115                 120                 125             


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
    130                 135                 140                 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
145                 150                 155                 160 


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
                165                 170                 175     


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
            180                 185                 190         


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        195                 200                 


<210>  9
<211>  357
<212>  DNA
<213>  artificial

<220>
<223>  humanized murine antibody 7D11heavy chain variable region

<400>  9
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttacc cggtactgga tgcactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatac attaatccta gcactggtta tactgagtac    180

aatcagaaat tcaaggacag agtcacgatt accgcggaca aatcaacgag cacagcctac    240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagaactaca    300

gtggatggtt acgactttgc ttactggggc caaggaaccc tggtcaccgt ctcctca       357


<210>  10
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized murine antibody 7D11 heavy chain variable region

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Thr Val Asp Gly Tyr Asp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  11
<211>  1350
<212>  DNA
<213>  artificial

<220>
<223>  humanized murine antibody 7D11 heavy chain

<400>  11
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttacc cggtactgga tgcactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatac attaatccta gcactggtta tactgagtac    180

aatcagaaat tcaaggacag agtcacgatt accgcggaca aatcaacgag cacagcctac    240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagaactaca    300

gtggatggtt acgactttgc ttactggggc caaggaaccc tggtcaccgt ctcctcagcc    360

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc    420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg    480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga    540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac    600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa    660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg    720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag    780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac    840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc    900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag    960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa   1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg   1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc   1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg   1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag   1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag   1320

aagagcctct ccctgtctcc gggtaaatga                                    1350


<210>  12
<211>  449
<212>  PRT
<213>  artificial

<220>
<223>  humanized murine 7D11 antibody heavy chain

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Thr Val Asp Gly Tyr Asp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Leu Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Pro Glu Glu Gln Tyr Asn Ser Thr Leu Arg Val 
    290                 295                 300                 


Val Ser Ile Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Leu Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  13
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  L1 viral protein binding site for antibodies 7D11 and h7D11

<400>  13

Glu Ala Asn Ala Ser Ala Gln Thr Lys Cys Asp Ile Glu 
1               5                   10              


<210>  14
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  L1 viral protein epitope for 7D11 and h7D11 antibodies

<400>  14

Met Cys Ser Ala Asp Ala Asp Ala Gln 
1               5                   


<210>  15
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  L1 viral protein epitope for 7D11 and h7D11 antibodies

<400>  15

Asp Asn Lys Leu Lys Ile Gln 
1               5           


<210>  16
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  Light Chain Variable Region of Ch6C antibody

<400>  16
gagctcgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa gatcactatt     60

tcctgctctg gaagcggctc caacattggg aggcattatg tatcctggta ccaacaattc    120

ccaggaacag cccccaaaat cctcatttat gacaatgata agcgaccctc agggatttcc    180

gaccgattct ctggctccaa gtctggcgcg tcagccaccc tggacatcac cggactccag    240

actggggacg aggccgatta ttactgcgca acatgggata ccaacttgag tggtggggtg    300

ttcggcggag ggactaaagt gacc                                           324


<210>  17
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  Light Chain Variable Region of Ch6C antibody

<400>  17

Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Ile Thr Ile Ser Cys Ser Gly Ser Gly Ser Asn Ile Gly Arg His 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Ile Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Ala Ser Ala Thr Leu Asp Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Thr Asn Leu 
                85                  90                  95      


Ser Gly Gly Val Phe Gly Gly Gly Thr Lys Val Thr 
            100                 105             


<210>  18
<211>  646
<212>  DNA
<213>  artificial

<220>
<223>  Light Chain of Ch6C antibody

<400>  18
gagctcgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa gatcactatt     60

tcctgctctg gaagcggctc caacattggg aggcattatg tatcctggta ccaacaattc    120

ccaggaacag cccccaaaat cctcatttat gacaatgata agcgaccctc agggatttcc    180

gaccgattct ctggctccaa gtctggcgcg tcagccaccc tggacatcac cggactccag    240

actggggacg aggccgatta ttactgcgca acatgggata ccaacttgag tggtggggtg    300

ttcggcggag ggactaaagt gaccgtccta ggtcagccca aggctgcccc ctcggtcact    360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata    420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag    480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc    540

tacctgagcc tgacgcccga gcagtggaag tcccacaaaa gctacagctg ccaggtcacg    600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgtt                   646


<210>  19
<211>  215
<212>  PRT
<213>  artificial

<220>
<223>  Light Chain of Ch6C antibody

<400>  19

Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Ile Thr Ile Ser Cys Ser Gly Ser Gly Ser Asn Ile Gly Arg His 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Ile Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Ala Ser Ala Thr Leu Asp Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Thr Asn Leu 
                85                  90                  95      


Ser Gly Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys 
    210                 215 


<210>  20
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  Heavy Chain Variable Region of Ch6C antibody

<400>  20
caggtgcagc tggtgcagtc tgggtctgag gtgaagaagc ctggggcctc agtgaagctt     60

tcctgcaagg cttctggata cacattcact agctactctt tgggctgggt gcgacaggcc    120

cctggacaag gacttgagtg gatgggatgg atcaacacca agactggaaa cccaacttat    180

gcccagggct tcacaggacg gtttgtcttc tccttggaca cgtctgtcaa cacggcatat    240

ctgcagatca ccagcctaaa ggctgaggac actgccgtat atttctgtgc gaaaggaaca    300

ttttactatg gttggggtcc ttactataat tggttcgacc cctggggcca gggagccctg    360

gtcaccgtct cctca                                                     375


<210>  21
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  Heavy Chain Variable Region of Ch6C antibody

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ser Leu Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Thr Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Gly Thr Phe Tyr Tyr Gly Trp Gly Pro Tyr Tyr Asn Trp Phe 
            100                 105                 110         


Asp Pro Trp Gly Gln Gly Ala Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  22
<211>  1368
<212>  DNA
<213>  artificial

<220>
<223>  Heavy Chain of Ch6C antibody

<400>  22
caggtgcagc tggtgcagtc tgggtctgag gtgaagaagc ctggggcctc agtgaagctt     60

tcctgcaagg cttctggata cacattcact agctactctt tgggctgggt gcgacaggcc    120

cctggacaag gacttgagtg gatgggatgg atcaacacca agactggaaa cccaacttat    180

gcccagggct tcacaggacg gtttgtcttc tccttggaca cgtctgtcaa cacggcatat    240

ctgcagatca ccagcctaaa ggctgaggac actgccgtat atttctgtgc gaaaggaaca    300

ttttactatg gttggggtcc ttactataat tggttcgacc cctggggcca gggagccctg    360

gtcaccgtct cctcagcctc caccaagggc ccatcggtct tccccctggc accctcctcc    420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa    480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct    540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc    600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac    660

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct    720

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg    780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag    840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg    900

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac    960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc   1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc   1080

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc   1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag   1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg   1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg   1320

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatga                1368


<210>  23
<211>  455
<212>  PRT
<213>  artificial

<220>
<223>  Heavy Chain of Ch6C antibody

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ser Leu Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Thr Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Gly Thr Phe Tyr Tyr Gly Trp Gly Pro Tyr Tyr Asn Trp Phe 
            100                 105                 110         


Asp Pro Trp Gly Gln Gly Ala Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  24
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  Light Chain Variable Region of Ch12F antibody

<400>  24
gagctcgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc     60

tcctgcactg gaaccagcag tgatgttggt ggttataacg ctgtctcctg gtaccaacag    120

cacccaggca aagcccccaa actcatgatt tatgaggtca ataagcggcc ctcaggggtt    180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc    240

caggctgagg acgaggctga ttattactgc agctcatata gaagcggagg aactgtggta    300

ttcggcggag ggaccaagct gacc                                           324


<210>  25
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  Light Chain Variable Region of Ch12F antibody

<400>  25

Glu Leu Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Ala Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Arg Ser Gly 
                85                  90                  95      


Gly Thr Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
            100                 105             


<210>  26
<211>  646
<212>  DNA
<213>  artificial

<220>
<223>  Light Chain of Ch12F antibody

<400>  26
gagctcgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc     60

tcctgcactg gaaccagcag tgatgttggt ggttataacg ctgtctcctg gtaccaacag    120

cacccaggca aagcccccaa actcatgatt tatgaggtca ataagcggcc ctcaggggtt    180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc    240

caggctgagg acgaggctga ttattactgc agctcatata gaagcggagg aactgtggta    300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact    360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata    420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag    480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc    540

tacctgagcc tgacgcccga gcagtggaag tcccacaaaa gctacagctg ccaggtcacg    600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgtt                   646


<210>  27
<211>  215
<212>  PRT
<213>  artificial

<220>
<223>  Light Chain of Ch12F antibody

<400>  27

Glu Leu Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Ala Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Arg Ser Gly 
                85                  90                  95      


Gly Thr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys 
    210                 215 


<210>  28
<211>  381
<212>  DNA
<213>  artificial

<220>
<223>  Heavy Chain Variable Region of Ch12F antibody

<400>  28
gaggtgcagc tggtgcagtc tggggcagag gtgaaaaagc ccggggagtc tctgaagata     60

tcctgtaagg gctctggata cacctttgcc agctactgga tcgtctgggt gcgccagatg    120

cccgggaaag gcctggagta catggggagc atctatcctg gtgactctgg taccagatat    180

agcccgtcct tccgaggcca ggtcaccatc tcagccgaca agtccatcaa caccgcctac    240

ttgcagtggg gcagcctgaa ggcctcggac accgccttct actactgtgc gagacttaag    300

ccccttcgtg ggtcgttatt cggggagcct attgggccct atgactactg gggccaggca    360

accctggtca ccgtctcctc a                                              381


<210>  29
<211>  127
<212>  PRT
<213>  artificial

<220>
<223>  Heavy Chain Variable Region of Ch12F antibody

<400>  29

Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ala Ser Tyr 
            20                  25                  30          


Trp Ile Val Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Ser Ile Tyr Pro Gly Asp Ser Gly Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Arg Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Gly Ser Leu Lys Ala Ser Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Lys Pro Leu Arg Gly Ser Leu Phe Gly Glu Pro Ile Gly 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Ala Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  30
<211>  1374
<212>  DNA
<213>  artificial

<220>
<223>  Heavy Chain of Ch12F antibody

<400>  30
gaggtgcagc tggtgcagtc tggggcagag gtgaaaaagc ccggggagtc tctgaagata     60

tcctgtaagg gctctggata cacctttgcc agctactgga tcgtctgggt gcgccagatg    120

cccgggaaag gcctggagta catggggagc atctatcctg gtgactctgg taccagatat    180

agcccgtcct tccgaggcca ggtcaccatc tcagccgaca agtccatcaa caccgcctac    240

ttgcagtggg gcagcctgaa ggcctcggac accgccttct actactgtgc gagacttaag    300

ccccttcgtg ggtcgttatt cggggagcct attgggccct atgactactg gggccaggca    360

accctggtca ccgtctcctc agcctccacc aagggcccat cggtcttccc cctggcaccc    420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc    480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc    540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc    600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag    660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca    720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc    780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac    840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag    900

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac    960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc   1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc   1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa   1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac   1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc   1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag   1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga         1374


<210>  31
<211>  457
<212>  PRT
<213>  artificial

<220>
<223>  Heavy Chain of Ch12F antibody

<400>  31

Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ala Ser Tyr 
            20                  25                  30          


Trp Ile Val Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Ser Ile Tyr Pro Gly Asp Ser Gly Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Arg Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Gly Ser Leu Lys Ala Ser Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Lys Pro Leu Arg Gly Ser Leu Phe Gly Glu Pro Ile Gly 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Ala Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  32
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  Light Chain Variable Region of Ch8AH8AL antibody

<400>  32
gagctcgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc     60

tcctgcactg gaggcagaag tgaccttggt gattctaact ttgtctcctg gtaccaacaa    120

tacccaggca aagcccccaa actcctgatt tatcaggtca ataagaggcc ctcaggggtc    180

cctgatcgct tctctgcgtc caagtctgcc aacacggcct ccctgaccat ctctgggctc    240

caaactgagg acgaggctga ctatttctgc agctcatata caaccaccag tacttatgtc    300

ttcggaattg ggaccaaggt cgtc                                           324


<210>  33
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  Light Chain Variable Region of Ch8AH8AL antibody

<400>  33

Glu Leu Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Gly Arg Ser Asp Leu Gly Asp Ser 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gln Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Ala Ser Lys Ser Ala Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Phe Cys Ser Ser Tyr Thr Thr Thr 
                85                  90                  95      


Ser Thr Tyr Val Phe Gly Ile Gly Thr Lys Val Val 
            100                 105             


<210>  34
<211>  646
<212>  DNA
<213>  artificial

<220>
<223>  Light Chain of Ch8AH8AL antibody

<400>  34
gagctcgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc     60

tcctgcactg gaggcagaag tgaccttggt gattctaact ttgtctcctg gtaccaacaa    120

tacccaggca aagcccccaa actcctgatt tatcaggtca ataagaggcc ctcaggggtc    180

cctgatcgct tctctgcgtc caagtctgcc aacacggcct ccctgaccat ctctgggctc    240

caaactgagg acgaggctga ctatttctgc agctcatata caaccaccag tacttatgtc    300

ttcggaattg ggaccaaggt cgtcgtcctc ggtcagccca aggccaaccc cacagtcacc    360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata    420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatggcag ccccgtcaag    480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc    540

tacctgagcc tgacgcccga gcagtggaag tcccacagaa gctacagctg ccaggtcacg    600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgtt                   646


<210>  35
<211>  216
<212>  PRT
<213>  artificial

<220>
<223>  Light Chain of Ch8AH8AL antibody

<400>  35

Glu Leu Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Gly Arg Ser Asp Leu Gly Asp Ser 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gln Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Ala Ser Lys Ser Ala Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Phe Cys Ser Ser Tyr Thr Thr Thr 
                85                  90                  95      


Ser Thr Tyr Val Phe Gly Ile Gly Thr Lys Val Val Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  36
<211>  363
<212>  DNA
<213>  artificial

<220>
<223>  Heavy Chain Variable Region for Ch8AH8AL antibody

<400>  36
gaggtgcagc tggtggagtc tgggggaggc ttaataaagc ctgggggatc cctgagactc     60

tcctgtgcag cctctggatt catctttagg gactataata tcaactgggt ccgccaggct    120

ccagggaagg ggctggagtg gctaggtttc ataaggacca gagcttcagg ccggtcaaca    180

gagtacagcg catctgtgaa aggcagattc actatctcaa gagatgattc caaaaacatt    240

gcctatctac acatcaatag cctgaaaatg gaggacacag ccgtgtatta ttgtgctaag    300

aaaggggaca gttactacta catggacttc tggggcaaag ggaccgcggt caccgtctcc    360

tca                                                                  363


<210>  37
<211>  121
<212>  PRT
<213>  artificial

<220>
<223>  Heavy Chain Variable Region for Ch8AH8AL antibody

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asp Tyr 
            20                  25                  30          


Asn Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Arg Thr Arg Ala Ser Gly Arg Ser Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ile 
65                  70                  75                  80  


Ala Tyr Leu His Ile Asn Ser Leu Lys Met Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Lys Gly Asp Ser Tyr Tyr Tyr Met Asp Phe Trp Gly 
            100                 105                 110         


Lys Gly Thr Ala Val Thr Val Ser Ser 
        115                 120     


<210>  38
<211>  1356
<212>  DNA
<213>  artificial

<220>
<223>  Heavy Chain of Ch8AH8AL antibody

<400>  38
gaggtgcagc tggtggagtc tgggggaggc ttaataaagc ctgggggatc cctgagactc     60

tcctgtgcag cctctggatt catctttagg gactataata tcaactgggt ccgccaggct    120

ccagggaagg ggctggagtg gctaggtttc ataaggacca gagcttcagg ccggtcaaca    180

gagtacagcg catctgtgaa aggcagattc actatctcaa gagatgattc caaaaacatt    240

gcctatctac acatcaatag cctgaaaatg gaggacacag ccgtgtatta ttgtgctaag    300

aaaggggaca gttactacta catggacttc tggggcaaag ggaccgcggt caccgtctcc    360

tcagcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct    420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg    480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc    540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag    600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag    660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg    720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc    780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac    840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac    900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc    960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc   1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat   1080

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac   1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc   1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg   1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac   1320

acgcagaaga gcctctccct gtctccgggt aaatga                             1356


<210>  39
<211>  451
<212>  PRT
<213>  artificial

<220>
<223>  Heavy Chain of Ch8AH8AL antibody

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asp Tyr 
            20                  25                  30          


Asn Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Arg Thr Arg Ala Ser Gly Arg Ser Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ile 
65                  70                  75                  80  


Ala Tyr Leu His Ile Asn Ser Leu Lys Met Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Lys Gly Asp Ser Tyr Tyr Tyr Met Asp Phe Trp Gly 
            100                 105                 110         


Lys Gly Thr Ala Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  40
<211>  87
<212>  PRT
<213>  artificial

<220>
<223>  Viral protein A33 epitope for Ch12F antibody

<400>  40

Ser Cys Asn Gly Leu Tyr Tyr Gln Gly Ser Cys Tyr Ile Leu His Ser 
1               5                   10                  15      


Asp Tyr Gln Leu Phe Ser Asp Ala Lys Ala Asn Cys Thr Ala Glu Ser 
            20                  25                  30          


Ser Thr Leu Pro Asn Lys Ser Asp Val Leu Ile Thr Trp Leu Ile Asp 
        35                  40                  45              


Tyr Val Glu Asp Thr Trp Gly Ser Asp Gly Asn Pro Ile Thr Lys Thr 
    50                  55                  60                  


Thr Ser Asp Tyr Gln Asp Ser Asp Val Ser Gln Glu Val Arg Lys Tyr 
65                  70                  75                  80  


Phe Cys Val Lys Thr Met Asn 
                85          


<210>  41
<211>  111
<212>  PRT
<213>  artificial

<220>
<223>  B5 viral protein epitope for Ch8AH8AL antibody

<400>  41

Thr Cys Thr Val Pro Thr Met Asn Asn Ala Lys Leu Thr Ser Thr Glu 
1               5                   10                  15      


Thr Ser Phe Asn Asp Lys Gln Lys Val Thr Phe Thr Cys Asp Gln Gly 
            20                  25                  30          


Tyr His Ser Ser Asp Pro Asn Ala Val Cys Glu Thr Asp Lys Trp Lys 
        35                  40                  45              


Tyr Glu Asn Pro Cys Lys Lys Met Cys Thr Val Ser Asp Tyr Ile Ser 
    50                  55                  60                  


Glu Leu Tyr Asn Lys Pro Leu Tyr Glu Val Asn Ser Thr Met Thr Leu 
65                  70                  75                  80  


Ser Cys Asn Gly Glu Thr Lys Tyr Phe Arg Cys Glu Glu Lys Asn Gly 
                85                  90                  95      


Asn Thr Ser Trp Asn Asp Thr Val Thr Cys Pro Asn Ala Glu Cys 
            100                 105                 110     


<210>  42
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  SJ15R primer

<400>  42
ggtcactgtc actggctcag gg                                              22


<210>  43
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  SJ16R primer

<400>  43
aggcggatcc aggggccagt ggatagac                                        28


<210>  44
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  lgh249r primer

<400>  44
cttccacttg acattgatgt ctttggg                                         27


