                         SEQUENCE LISTING

<110>  WEINER , DAVID B.
       MUTHUMANI, KARUPPIAH
 
<120>  CONSENSUS SEQUENCES OF CHIKUNGUNYA VIRAL PROTEINS, NUCLEIC ACID 
       MOLECULES ENCODING THE SAME AND COMPOSITIONS AND METHODS FOR 
       USING THE SAME

<130>  130694.06302

<150>  61/042661
<151>  2008-04-04

<160>  18    

<170>  PatentIn version 3.4

<210>  1
<211>  1374
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHIKV E1 consensus

<400>  1
atggactgga cctggatcct gtttctggtc gctgctgcca cccgggtgca cagctacgag     60

cacgtgaccg tgatccccaa caccgtgggc gtgccctaca agaccctggt gaacaggccc    120

ggctacagcc ccatggtgct ggaaatggaa ctgctgtccg tgaccctgga acccaccctg    180

agcctggact acatcacctg cgagtacaag acagtgatcc ccagccccta cgtgaagtgc    240

tgcggcaccg ccgagtgcaa ggacaagaac ctgcccgact acagctgcaa ggtgttcacc    300

ggcgtgtacc ccttcatgtg gggcggagcc tactgcttct gcgacgccga gaacacccag    360

ctgtccgagg cccacgtgga gaagagcgag agctgcaaga ccgagttcgc cagcgcctac    420

cgggcccaca cagccagcgc cagcgccaag ctgcgggtgc tgtaccaggg caacaacatc    480

accgtgaccg cctacgccaa cggcgaccac gccgtgacag tgaaggacgc caagttcatc    540

gtgggcccca tgagcagcgc ctggaccccc ttcgacaaca agatcgtggt gtacaagggc    600

gacgtgtaca acatggacta cccccccttc ggagccggca gacccggcca gttcggcgac    660

atccagagcc ggacccccga gagcaaggac gtgtacgcca atacccagct ggtgctgcag    720

agacccgccg tgggcaccgt gcacgtgcct tacagccagg cccccagcgg cttcaagtac    780

tggctgaaag agaggggcgc cagcctgcag cacaccgccc ccttcggctg ccagatcgcc    840

accaaccccg tgcgggccgt gaattgtgcc gtgggcaaca tgcccatcag catcgacatc    900

cccgaggccg ccttcaccag ggtggtggac gcccccagcc tgaccgacat gagctgcgag    960

gtgcccgcct gcacccacag cagcgacttc ggcggcgtgg ccatcatcaa gtacgccgcc   1020

agcaagaaag gcaagtgcgc cgtgcacagc atgaccaatg ccgtgaccat ccgggaggcc   1080

gagatcgagg tggagggcaa cagccagctg cagatcagct tcagcaccgc cctggccagc   1140

gccgagttcc gggtgcaggt ctgcagcacc caggtgcact gtgccgccga gtgtcacccc   1200

cccaaggacc acatcgtgaa ctaccccgcc agccacacca ccctgggcgt gcaggacatc   1260

agcgccaccg ccatgagctg ggtgcagaag atcacaggcg gcgtcggcct ggtggtggcc   1320

gtggccgccc tgatcctgat cgtggtgctg tgcgtgagct tcagccggca ctga         1374


<210>  2
<211>  1326
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHIKV E2 consensus

<400>  2
atggactgga cctggatcct gttcctggtc gctgctgcca caagagtgca cagcagcacc     60

aaggacaact tcaacgtgta caaggccacc cggccctacc tggcccactg ccccgattgc    120

ggcgagggcc acagctgcca cagccccgtg gccctggaac ggatccggaa cgaggccacc    180

gacggcaccc tgaagatcca ggtgtccctg cagatcggca tcaagaccga cgacagccac    240

gactggacca agctgcggta catggacaac cacatgcccg ccgacgccga gagagccggc    300

ctgttcgtcc ggaccagcgc cccctgcacc atcaccggca ccatgggcca cttcatcctg    360

gcccggtgcc ccaagggcga gacactgacc gtgggcttca ccgacagccg gaagatcagc    420

cactcctgca cccacccctt ccaccacgac ccccccgtga tcggccggga gaagttccac    480

agcaggcccc agcacggcaa agagctgccc tgcagcacct acgtgcagag caccgccgcc    540

acaaccgagg aaatcgaggt gcacatgccc cccgataccc ccgaccggac cctgatgagc    600

cagcagagcg gcaacgtgaa gatcaccgtg aacggccaga ccgtgcggta caagtgcaac    660

tgcggcggca gcaacgaggg cctgaccacc accgacaagg tgatcaacaa ctgcaaggtg    720

gaccagtgcc acgccgccgt gaccaaccac aagaagtggc agtacaacag ccccctggtg    780

ccccggaatg ccgagctggg cgaccggaag ggcaagatcc acatcccctt ccccctggcc    840

aacgtgacct gccgggtgcc caaggcccgg aaccccaccg tgacctacgg caagaaccag    900

gtgatcatgc tgctgtaccc cgaccacccc accctgctgt cctaccggaa catgggcgag    960

gaacccaact accaagagga gtgggtcatg cacaagaaag aagtggtgct gaccgtcccc   1020

accgagggcc tggaagtgac ctggggcaac aacgagccct acaagtactg gccccagctg   1080

tccaccaacg gcaccgccca cggccacccc cacgagatca tcctgtacta ctacgagctg   1140

taccctacca tgaccgtggt ggtggtgtcc gtggccacct ttatcctgct gtccatggtc   1200

ggcatggccg ctggcatgtg catgtgcgcc aggaggcgct gtatcacccc ctacgagctg   1260

acacctggcg ccaccgtgcc ctttctgctg tccctgatct gctgcatccg gaccgccaag   1320

gcctga                                                              1326


<210>  3
<211>  840
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHIKV capsid consensus

<400>  3
atggactgga cctggatcct gttcctggtg gccgctgcca cccgggtgca cagcatggaa     60

ttcatcccca cccagacctt ctacaaccgg cgctaccagc ccagaccctg gacccccagg    120

cccaccatcc aggtgatccg gcccaggccc agaccccaga ggcaggccgg gcagctggca    180

cagctgatca gcgccgtgaa caagctgacc atgagagccg tgccccagca gaagcccagg    240

cggaaccgga agaacaagaa gcagaagcag aaacagcagg ccccccagaa caacaccaac    300

cagaagaagc agccccccaa gaagaagcct gcccagaaga agaagaaacc cggcaggcgg    360

gagcggatgt gcatgaagat cgagaacgac tgcatcttcg aggtgaagca cgagggcaag    420

gtgaccggct acgcctgcct ggtcggcgac aaagtgatga agcccgccca cgtgaagggc    480

accatcgaca acgccgacct ggccaagctg gccttcaagc ggagcagcaa gtacgacctg    540

gaatgcgccc agatccccgt gcacatgaag agcgacgcca gcaagttcac ccacgagaag    600

cccgagggct actacaactg gcaccacgga gccgtgcagt acagcggcgg caggttcacc    660

atccccacag gcgccggaaa gcccggcgac agcggcaggc ccatcttcga caacaagggc    720

cgggtggtgg ccatcgtgct gggcggagcc aacgagggcg ccaggaccgc cctgagcgtg    780

gtgacctgga acaaggacat cgtgaccaag atcacccccg agggcgccga agagtggtga    840


<210>  4
<211>  1320
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHIKV E1 consensus

<400>  4
tacgagcacg tgaccgtgat ccccaacacc gtgggcgtgc cctacaagac cctggtgaac     60

aggcccggct acagccccat ggtgctggaa atggaactgc tgtccgtgac cctggaaccc    120

accctgagcc tggactacat cacctgcgag tacaagacag tgatccccag cccctacgtg    180

aagtgctgcg gcaccgccga gtgcaaggac aagaacctgc ccgactacag ctgcaaggtg    240

ttcaccggcg tgtacccctt catgtggggc ggagcctact gcttctgcga cgccgagaac    300

acccagctgt ccgaggccca cgtggagaag agcgagagct gcaagaccga gttcgccagc    360

gcctaccggg cccacacagc cagcgccagc gccaagctgc gggtgctgta ccagggcaac    420

aacatcaccg tgaccgccta cgccaacggc gaccacgccg tgacagtgaa ggacgccaag    480

ttcatcgtgg gccccatgag cagcgcctgg acccccttcg acaacaagat cgtggtgtac    540

aagggcgacg tgtacaacat ggactacccc cccttcggag ccggcagacc cggccagttc    600

ggcgacatcc agagccggac ccccgagagc aaggacgtgt acgccaatac ccagctggtg    660

ctgcagagac ccgccgtggg caccgtgcac gtgccttaca gccaggcccc cagcggcttc    720

aagtactggc tgaaagagag gggcgccagc ctgcagcaca ccgccccctt cggctgccag    780

atcgccacca accccgtgcg ggccgtgaat tgtgccgtgg gcaacatgcc catcagcatc    840

gacatccccg aggccgcctt caccagggtg gtggacgccc ccagcctgac cgacatgagc    900

tgcgaggtgc ccgcctgcac ccacagcagc gacttcggcg gcgtggccat catcaagtac    960

gccgccagca agaaaggcaa gtgcgccgtg cacagcatga ccaatgccgt gaccatccgg   1020

gaggccgaga tcgaggtgga gggcaacagc cagctgcaga tcagcttcag caccgccctg   1080

gccagcgccg agttccgggt gcaggtctgc agcacccagg tgcactgtgc cgccgagtgt   1140

caccccccca aggaccacat cgtgaactac cccgccagcc acaccaccct gggcgtgcag   1200

gacatcagcg ccaccgccat gagctgggtg cagaagatca caggcggcgt cggcctggtg   1260

gtggccgtgg ccgccctgat cctgatcgtg gtgctgtgcg tgagcttcag ccggcactga   1320


<210>  5
<211>  1273
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHIKV E2 consensus

<400>  5
cagcaccaag gacaacttca acgtgtacaa ggccacccgg ccctacctgg cccactgccc     60

cgattgcggc gagggccaca gctgccacag ccccgtggcc ctggaacgga tccggaacga    120

ggccaccgac ggcaccctga agatccaggt gtccctgcag atcggcatca agaccgacga    180

cagccacgac tggaccaagc tgcggtacat ggacaaccac atgcccgccg acgccgagag    240

agccggcctg ttcgtccgga ccagcgcccc ctgcaccatc accggcacca tgggccactt    300

catcctggcc cggtgcccca agggcgagac actgaccgtg ggcttcaccg acagccggaa    360

gatcagccac tcctgcaccc accccttcca ccacgacccc cccgtgatcg gccgggagaa    420

gttccacagc aggccccagc acggcaaaga gctgccctgc agcacctacg tgcagagcac    480

cgccgccaca accgaggaaa tcgaggtgca catgcccccc gatacccccg accggaccct    540

gatgagccag cagagcggca acgtgaagat caccgtgaac ggccagaccg tgcggtacaa    600

gtgcaactgc ggcggcagca acgagggcct gaccaccacc gacaaggtga tcaacaactg    660

caaggtggac cagtgccacg ccgccgtgac caaccacaag aagtggcagt acaacagccc    720

cctggtgccc cggaatgccg agctgggcga ccggaagggc aagatccaca tccccttccc    780

cctggccaac gtgacctgcc gggtgcccaa ggcccggaac cccaccgtga cctacggcaa    840

gaaccaggtg atcatgctgc tgtaccccga ccaccccacc ctgctgtcct accggaacat    900

gggcgaggaa cccaactacc aagaggagtg ggtcatgcac aagaaagaag tggtgctgac    960

cgtccccacc gagggcctgg aagtgacctg gggcaacaac gagccctaca agtactggcc   1020

ccagctgtcc accaacggca ccgcccacgg ccacccccac gagatcatcc tgtactacta   1080

cgagctgtac cctaccatga ccgtggtggt ggtgtccgtg gccaccttta tcctgctgtc   1140

catggtcggc atggccgctg gcatgtgcat gtgcgccagg aggcgctgta tcacccccta   1200

cgagctgaca cctggcgcca ccgtgccctt tctgctgtcc ctgatctgct gcatccggac   1260

cgccaaggcc tga                                                      1273


<210>  6
<211>  786
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHIKV capsid consensus

<400>  6
atggaattca tccccaccca gaccttctac aaccggcgct accagcccag accctggacc     60

cccaggccca ccatccaggt gatccggccc aggcccagac cccagaggca ggccgggcag    120

ctggcacagc tgatcagcgc cgtgaacaag ctgaccatga gagccgtgcc ccagcagaag    180

cccaggcgga accggaagaa caagaagcag aagcagaaac agcaggcccc ccagaacaac    240

accaaccaga agaagcagcc ccccaagaag aagcctgccc agaagaagaa gaaacccggc    300

aggcgggagc ggatgtgcat gaagatcgag aacgactgca tcttcgaggt gaagcacgag    360

ggcaaggtga ccggctacgc ctgcctggtc ggcgacaaag tgatgaagcc cgcccacgtg    420

aagggcacca tcgacaacgc cgacctggcc aagctggcct tcaagcggag cagcaagtac    480

gacctggaat gcgcccagat ccccgtgcac atgaagagcg acgccagcaa gttcacccac    540

gagaagcccg agggctacta caactggcac cacggagccg tgcagtacag cggcggcagg    600

ttcaccatcc ccacaggcgc cggaaagccc ggcgacagcg gcaggcccat cttcgacaac    660

aagggccggg tggtggccat cgtgctgggc ggagccaacg agggcgccag gaccgccctg    720

agcgtggtga cctggaacaa ggacatcgtg accaagatca cccccgaggg cgccgaagag    780

tggtga                                                               786


<210>  7
<211>  457
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHIKV E1 consensus

<400>  7

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Tyr Glu His Val Thr Val Ile Pro Asn Thr Val Gly Val Pro 
            20                  25                  30          


Tyr Lys Thr Leu Val Asn Arg Pro Gly Tyr Ser Pro Met Val Leu Glu 
        35                  40                  45              


Met Glu Leu Leu Ser Val Thr Leu Glu Pro Thr Leu Ser Leu Asp Tyr 
    50                  55                  60                  


Ile Thr Cys Glu Tyr Lys Thr Val Ile Pro Ser Pro Tyr Val Lys Cys 
65                  70                  75                  80  


Cys Gly Thr Ala Glu Cys Lys Asp Lys Asn Leu Pro Asp Tyr Ser Cys 
                85                  90                  95      


Lys Val Phe Thr Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Tyr Cys 
            100                 105                 110         


Phe Cys Asp Ala Glu Asn Thr Gln Leu Ser Glu Ala His Val Glu Lys 
        115                 120                 125             


Ser Glu Ser Cys Lys Thr Glu Phe Ala Ser Ala Tyr Arg Ala His Thr 
    130                 135                 140                 


Ala Ser Ala Ser Ala Lys Leu Arg Val Leu Tyr Gln Gly Asn Asn Ile 
145                 150                 155                 160 


Thr Val Thr Ala Tyr Ala Asn Gly Asp His Ala Val Thr Val Lys Asp 
                165                 170                 175     


Ala Lys Phe Ile Val Gly Pro Met Ser Ser Ala Trp Thr Pro Phe Asp 
            180                 185                 190         


Asn Lys Ile Val Val Tyr Lys Gly Asp Val Tyr Asn Met Asp Tyr Pro 
        195                 200                 205             


Pro Phe Gly Ala Gly Arg Pro Gly Gln Phe Gly Asp Ile Gln Ser Arg 
    210                 215                 220                 


Thr Pro Glu Ser Lys Asp Val Tyr Ala Asn Thr Gln Leu Val Leu Gln 
225                 230                 235                 240 


Arg Pro Ala Val Gly Thr Val His Val Pro Tyr Ser Gln Ala Pro Ser 
                245                 250                 255     


Gly Phe Lys Tyr Trp Leu Lys Glu Arg Gly Ala Ser Leu Gln His Thr 
            260                 265                 270         


Ala Pro Phe Gly Cys Gln Ile Ala Thr Asn Pro Val Arg Ala Val Asn 
        275                 280                 285             


Cys Ala Val Gly Asn Met Pro Ile Ser Ile Asp Ile Pro Glu Ala Ala 
    290                 295                 300                 


Phe Thr Arg Val Val Asp Ala Pro Ser Leu Thr Asp Met Ser Cys Glu 
305                 310                 315                 320 


Val Pro Ala Cys Thr His Ser Ser Asp Phe Gly Gly Val Ala Ile Ile 
                325                 330                 335     


Lys Tyr Ala Ala Ser Lys Lys Gly Lys Cys Ala Val His Ser Met Thr 
            340                 345                 350         


Asn Ala Val Thr Ile Arg Glu Ala Glu Ile Glu Val Glu Gly Asn Ser 
        355                 360                 365             


Gln Leu Gln Ile Ser Phe Ser Thr Ala Leu Ala Ser Ala Glu Phe Arg 
    370                 375                 380                 


Val Gln Val Cys Ser Thr Gln Val His Cys Ala Ala Glu Cys His Pro 
385                 390                 395                 400 


Pro Lys Asp His Ile Val Asn Tyr Pro Ala Ser His Thr Thr Leu Gly 
                405                 410                 415     


Val Gln Asp Ile Ser Ala Thr Ala Met Ser Trp Val Gln Lys Ile Thr 
            420                 425                 430         


Gly Gly Val Gly Leu Val Val Ala Val Ala Ala Leu Ile Leu Ile Val 
        435                 440                 445             


Val Leu Cys Val Ser Phe Ser Arg His 
    450                 455         


<210>  8
<211>  441
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHIKV E2 consensus

<400>  8

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Thr Lys Asp Asn Phe Asn Val Tyr Lys Ala Thr Arg Pro 
            20                  25                  30          


Tyr Leu Ala His Cys Pro Asp Cys Gly Glu Gly His Ser Cys His Ser 
        35                  40                  45              


Pro Val Ala Leu Glu Arg Ile Arg Asn Glu Ala Thr Asp Gly Thr Leu 
    50                  55                  60                  


Lys Ile Gln Val Ser Leu Gln Ile Gly Ile Lys Thr Asp Asp Ser His 
65                  70                  75                  80  


Asp Trp Thr Lys Leu Arg Tyr Met Asp Asn His Met Pro Ala Asp Ala 
                85                  90                  95      


Glu Arg Ala Gly Leu Phe Val Arg Thr Ser Ala Pro Cys Thr Ile Thr 
            100                 105                 110         


Gly Thr Met Gly His Phe Ile Leu Ala Arg Cys Pro Lys Gly Glu Thr 
        115                 120                 125             


Leu Thr Val Gly Phe Thr Asp Ser Arg Lys Ile Ser His Ser Cys Thr 
    130                 135                 140                 


His Pro Phe His His Asp Pro Pro Val Ile Gly Arg Glu Lys Phe His 
145                 150                 155                 160 


Ser Arg Pro Gln His Gly Lys Glu Leu Pro Cys Ser Thr Tyr Val Gln 
                165                 170                 175     


Ser Thr Ala Ala Thr Thr Glu Glu Ile Glu Val His Met Pro Pro Asp 
            180                 185                 190         


Thr Pro Asp Arg Thr Leu Met Ser Gln Gln Ser Gly Asn Val Lys Ile 
        195                 200                 205             


Thr Val Asn Gly Gln Thr Val Arg Tyr Lys Cys Asn Cys Gly Gly Ser 
    210                 215                 220                 


Asn Glu Gly Leu Thr Thr Thr Asp Lys Val Ile Asn Asn Cys Lys Val 
225                 230                 235                 240 


Asp Gln Cys His Ala Ala Val Thr Asn His Lys Lys Trp Gln Tyr Asn 
                245                 250                 255     


Ser Pro Leu Val Pro Arg Asn Ala Glu Leu Gly Asp Arg Lys Gly Lys 
            260                 265                 270         


Ile His Ile Pro Phe Pro Leu Ala Asn Val Thr Cys Arg Val Pro Lys 
        275                 280                 285             


Ala Arg Asn Pro Thr Val Thr Tyr Gly Lys Asn Gln Val Ile Met Leu 
    290                 295                 300                 


Leu Tyr Pro Asp His Pro Thr Leu Leu Ser Tyr Arg Asn Met Gly Glu 
305                 310                 315                 320 


Glu Pro Asn Tyr Gln Glu Glu Trp Val Met His Lys Lys Glu Val Val 
                325                 330                 335     


Leu Thr Val Pro Thr Glu Gly Leu Glu Val Thr Trp Gly Asn Asn Glu 
            340                 345                 350         


Pro Tyr Lys Tyr Trp Pro Gln Leu Ser Thr Asn Gly Thr Ala His Gly 
        355                 360                 365             


His Pro His Glu Ile Ile Leu Tyr Tyr Tyr Glu Leu Tyr Pro Thr Met 
    370                 375                 380                 


Thr Val Val Val Val Ser Val Ala Thr Phe Ile Leu Leu Ser Met Val 
385                 390                 395                 400 


Gly Met Ala Ala Gly Met Cys Met Cys Ala Arg Arg Arg Cys Ile Thr 
                405                 410                 415     


Pro Tyr Glu Leu Thr Pro Gly Ala Thr Val Pro Phe Leu Leu Ser Leu 
            420                 425                 430         


Ile Cys Cys Ile Arg Thr Ala Lys Ala 
        435                 440     


<210>  9
<211>  279
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHIKV capsid consensus

<400>  9

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Met Glu Phe Ile Pro Thr Gln Thr Phe Tyr Asn Arg Arg Tyr 
            20                  25                  30          


Gln Pro Arg Pro Trp Thr Pro Arg Pro Thr Ile Gln Val Ile Arg Pro 
        35                  40                  45              


Arg Pro Arg Pro Gln Arg Gln Ala Gly Gln Leu Ala Gln Leu Ile Ser 
    50                  55                  60                  


Ala Val Asn Lys Leu Thr Met Arg Ala Val Pro Gln Gln Lys Pro Arg 
65                  70                  75                  80  


Arg Asn Arg Lys Asn Lys Lys Gln Lys Gln Lys Gln Gln Ala Pro Gln 
                85                  90                  95      


Asn Asn Thr Asn Gln Lys Lys Gln Pro Pro Lys Lys Lys Pro Ala Gln 
            100                 105                 110         


Lys Lys Lys Lys Pro Gly Arg Arg Glu Arg Met Cys Met Lys Ile Glu 
        115                 120                 125             


Asn Asp Cys Ile Phe Glu Val Lys His Glu Gly Lys Val Thr Gly Tyr 
    130                 135                 140                 


Ala Cys Leu Val Gly Asp Lys Val Met Lys Pro Ala His Val Lys Gly 
145                 150                 155                 160 


Thr Ile Asp Asn Ala Asp Leu Ala Lys Leu Ala Phe Lys Arg Ser Ser 
                165                 170                 175     


Lys Tyr Asp Leu Glu Cys Ala Gln Ile Pro Val His Met Lys Ser Asp 
            180                 185                 190         


Ala Ser Lys Phe Thr His Glu Lys Pro Glu Gly Tyr Tyr Asn Trp His 
        195                 200                 205             


His Gly Ala Val Gln Tyr Ser Gly Gly Arg Phe Thr Ile Pro Thr Gly 
    210                 215                 220                 


Ala Gly Lys Pro Gly Asp Ser Gly Arg Pro Ile Phe Asp Asn Lys Gly 
225                 230                 235                 240 


Arg Val Val Ala Ile Val Leu Gly Gly Ala Asn Glu Gly Ala Arg Thr 
                245                 250                 255     


Ala Leu Ser Val Val Thr Trp Asn Lys Asp Ile Val Thr Lys Ile Thr 
            260                 265                 270         


Pro Glu Gly Ala Glu Glu Trp 
        275                 


<210>  10
<211>  439
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHIKV E1 consensus

<400>  10

Tyr Glu His Val Thr Val Ile Pro Asn Thr Val Gly Val Pro Tyr Lys 
1               5                   10                  15      


Thr Leu Val Asn Arg Pro Gly Tyr Ser Pro Met Val Leu Glu Met Glu 
            20                  25                  30          


Leu Leu Ser Val Thr Leu Glu Pro Thr Leu Ser Leu Asp Tyr Ile Thr 
        35                  40                  45              


Cys Glu Tyr Lys Thr Val Ile Pro Ser Pro Tyr Val Lys Cys Cys Gly 
    50                  55                  60                  


Thr Ala Glu Cys Lys Asp Lys Asn Leu Pro Asp Tyr Ser Cys Lys Val 
65                  70                  75                  80  


Phe Thr Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Tyr Cys Phe Cys 
                85                  90                  95      


Asp Ala Glu Asn Thr Gln Leu Ser Glu Ala His Val Glu Lys Ser Glu 
            100                 105                 110         


Ser Cys Lys Thr Glu Phe Ala Ser Ala Tyr Arg Ala His Thr Ala Ser 
        115                 120                 125             


Ala Ser Ala Lys Leu Arg Val Leu Tyr Gln Gly Asn Asn Ile Thr Val 
    130                 135                 140                 


Thr Ala Tyr Ala Asn Gly Asp His Ala Val Thr Val Lys Asp Ala Lys 
145                 150                 155                 160 


Phe Ile Val Gly Pro Met Ser Ser Ala Trp Thr Pro Phe Asp Asn Lys 
                165                 170                 175     


Ile Val Val Tyr Lys Gly Asp Val Tyr Asn Met Asp Tyr Pro Pro Phe 
            180                 185                 190         


Gly Ala Gly Arg Pro Gly Gln Phe Gly Asp Ile Gln Ser Arg Thr Pro 
        195                 200                 205             


Glu Ser Lys Asp Val Tyr Ala Asn Thr Gln Leu Val Leu Gln Arg Pro 
    210                 215                 220                 


Ala Val Gly Thr Val His Val Pro Tyr Ser Gln Ala Pro Ser Gly Phe 
225                 230                 235                 240 


Lys Tyr Trp Leu Lys Glu Arg Gly Ala Ser Leu Gln His Thr Ala Pro 
                245                 250                 255     


Phe Gly Cys Gln Ile Ala Thr Asn Pro Val Arg Ala Val Asn Cys Ala 
            260                 265                 270         


Val Gly Asn Met Pro Ile Ser Ile Asp Ile Pro Glu Ala Ala Phe Thr 
        275                 280                 285             


Arg Val Val Asp Ala Pro Ser Leu Thr Asp Met Ser Cys Glu Val Pro 
    290                 295                 300                 


Ala Cys Thr His Ser Ser Asp Phe Gly Gly Val Ala Ile Ile Lys Tyr 
305                 310                 315                 320 


Ala Ala Ser Lys Lys Gly Lys Cys Ala Val His Ser Met Thr Asn Ala 
                325                 330                 335     


Val Thr Ile Arg Glu Ala Glu Ile Glu Val Glu Gly Asn Ser Gln Leu 
            340                 345                 350         


Gln Ile Ser Phe Ser Thr Ala Leu Ala Ser Ala Glu Phe Arg Val Gln 
        355                 360                 365             


Val Cys Ser Thr Gln Val His Cys Ala Ala Glu Cys His Pro Pro Lys 
    370                 375                 380                 


Asp His Ile Val Asn Tyr Pro Ala Ser His Thr Thr Leu Gly Val Gln 
385                 390                 395                 400 


Asp Ile Ser Ala Thr Ala Met Ser Trp Val Gln Lys Ile Thr Gly Gly 
                405                 410                 415     


Val Gly Leu Val Val Ala Val Ala Ala Leu Ile Leu Ile Val Val Leu 
            420                 425                 430         


Cys Val Ser Phe Ser Arg His 
        435                 


<210>  11
<211>  423
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHIKV E2 consensus

<400>  11

Ser Thr Lys Asp Asn Phe Asn Val Tyr Lys Ala Thr Arg Pro Tyr Leu 
1               5                   10                  15      


Ala His Cys Pro Asp Cys Gly Glu Gly His Ser Cys His Ser Pro Val 
            20                  25                  30          


Ala Leu Glu Arg Ile Arg Asn Glu Ala Thr Asp Gly Thr Leu Lys Ile 
        35                  40                  45              


Gln Val Ser Leu Gln Ile Gly Ile Lys Thr Asp Asp Ser His Asp Trp 
    50                  55                  60                  


Thr Lys Leu Arg Tyr Met Asp Asn His Met Pro Ala Asp Ala Glu Arg 
65                  70                  75                  80  


Ala Gly Leu Phe Val Arg Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr 
                85                  90                  95      


Met Gly His Phe Ile Leu Ala Arg Cys Pro Lys Gly Glu Thr Leu Thr 
            100                 105                 110         


Val Gly Phe Thr Asp Ser Arg Lys Ile Ser His Ser Cys Thr His Pro 
        115                 120                 125             


Phe His His Asp Pro Pro Val Ile Gly Arg Glu Lys Phe His Ser Arg 
    130                 135                 140                 


Pro Gln His Gly Lys Glu Leu Pro Cys Ser Thr Tyr Val Gln Ser Thr 
145                 150                 155                 160 


Ala Ala Thr Thr Glu Glu Ile Glu Val His Met Pro Pro Asp Thr Pro 
                165                 170                 175     


Asp Arg Thr Leu Met Ser Gln Gln Ser Gly Asn Val Lys Ile Thr Val 
            180                 185                 190         


Asn Gly Gln Thr Val Arg Tyr Lys Cys Asn Cys Gly Gly Ser Asn Glu 
        195                 200                 205             


Gly Leu Thr Thr Thr Asp Lys Val Ile Asn Asn Cys Lys Val Asp Gln 
    210                 215                 220                 


Cys His Ala Ala Val Thr Asn His Lys Lys Trp Gln Tyr Asn Ser Pro 
225                 230                 235                 240 


Leu Val Pro Arg Asn Ala Glu Leu Gly Asp Arg Lys Gly Lys Ile His 
                245                 250                 255     


Ile Pro Phe Pro Leu Ala Asn Val Thr Cys Arg Val Pro Lys Ala Arg 
            260                 265                 270         


Asn Pro Thr Val Thr Tyr Gly Lys Asn Gln Val Ile Met Leu Leu Tyr 
        275                 280                 285             


Pro Asp His Pro Thr Leu Leu Ser Tyr Arg Asn Met Gly Glu Glu Pro 
    290                 295                 300                 


Asn Tyr Gln Glu Glu Trp Val Met His Lys Lys Glu Val Val Leu Thr 
305                 310                 315                 320 


Val Pro Thr Glu Gly Leu Glu Val Thr Trp Gly Asn Asn Glu Pro Tyr 
                325                 330                 335     


Lys Tyr Trp Pro Gln Leu Ser Thr Asn Gly Thr Ala His Gly His Pro 
            340                 345                 350         


His Glu Ile Ile Leu Tyr Tyr Tyr Glu Leu Tyr Pro Thr Met Thr Val 
        355                 360                 365             


Val Val Val Ser Val Ala Thr Phe Ile Leu Leu Ser Met Val Gly Met 
    370                 375                 380                 


Ala Ala Gly Met Cys Met Cys Ala Arg Arg Arg Cys Ile Thr Pro Tyr 
385                 390                 395                 400 


Glu Leu Thr Pro Gly Ala Thr Val Pro Phe Leu Leu Ser Leu Ile Cys 
                405                 410                 415     


Cys Ile Arg Thr Ala Lys Ala 
            420             


<210>  12
<211>  261
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHIKV capsid consensus

<400>  12

Met Glu Phe Ile Pro Thr Gln Thr Phe Tyr Asn Arg Arg Tyr Gln Pro 
1               5                   10                  15      


Arg Pro Trp Thr Pro Arg Pro Thr Ile Gln Val Ile Arg Pro Arg Pro 
            20                  25                  30          


Arg Pro Gln Arg Gln Ala Gly Gln Leu Ala Gln Leu Ile Ser Ala Val 
        35                  40                  45              


Asn Lys Leu Thr Met Arg Ala Val Pro Gln Gln Lys Pro Arg Arg Asn 
    50                  55                  60                  


Arg Lys Asn Lys Lys Gln Lys Gln Lys Gln Gln Ala Pro Gln Asn Asn 
65                  70                  75                  80  


Thr Asn Gln Lys Lys Gln Pro Pro Lys Lys Lys Pro Ala Gln Lys Lys 
                85                  90                  95      


Lys Lys Pro Gly Arg Arg Glu Arg Met Cys Met Lys Ile Glu Asn Asp 
            100                 105                 110         


Cys Ile Phe Glu Val Lys His Glu Gly Lys Val Thr Gly Tyr Ala Cys 
        115                 120                 125             


Leu Val Gly Asp Lys Val Met Lys Pro Ala His Val Lys Gly Thr Ile 
    130                 135                 140                 


Asp Asn Ala Asp Leu Ala Lys Leu Ala Phe Lys Arg Ser Ser Lys Tyr 
145                 150                 155                 160 


Asp Leu Glu Cys Ala Gln Ile Pro Val His Met Lys Ser Asp Ala Ser 
                165                 170                 175     


Lys Phe Thr His Glu Lys Pro Glu Gly Tyr Tyr Asn Trp His His Gly 
            180                 185                 190         


Ala Val Gln Tyr Ser Gly Gly Arg Phe Thr Ile Pro Thr Gly Ala Gly 
        195                 200                 205             


Lys Pro Gly Asp Ser Gly Arg Pro Ile Phe Asp Asn Lys Gly Arg Val 
    210                 215                 220                 


Val Ala Ile Val Leu Gly Gly Ala Asn Glu Gly Ala Arg Thr Ala Leu 
225                 230                 235                 240 


Ser Val Val Thr Trp Asn Lys Asp Ile Val Thr Lys Ile Thr Pro Glu 
                245                 250                 255     


Gly Ala Glu Glu Trp 
            260     


<210>  13
<211>  3008
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHIKV Env consensus

<400>  13

Ala Thr Gly Gly Ala Cys Thr Gly Gly Ala Cys Cys Thr Gly Gly Ala 
1               5                   10                  15      


Thr Cys Cys Thr Gly Thr Thr Cys Cys Thr Gly Gly Thr Gly Gly Cys 
            20                  25                  30          


Thr Gly Cys Thr Gly Cys Cys Ala Cys Cys Cys Gly Cys Gly Thr Gly 
        35                  40                  45              


Cys Ala Cys Ala Gly Cys Ala Gly Cys Cys Thr Gly Gly Cys Cys Ala 
    50                  55                  60                  


Thr Cys Cys Cys Cys Gly Thr Gly Ala Thr Gly Thr Gly Cys Cys Thr 
65                  70                  75                  80  


Gly Cys Thr Gly Gly Cys Cys Ala Ala Cys Ala Cys Cys Ala Cys Cys 
                85                  90                  95      


Thr Thr Cys Cys Cys Thr Thr Gly Cys Ala Gly Cys Cys Ala Gly Cys 
            100                 105                 110         


Cys Cys Cys Cys Cys Thr Gly Cys Ala Cys Cys Cys Cys Cys Thr Gly 
        115                 120                 125             


Cys Thr Gly Cys Thr Ala Cys Gly Ala Gly Ala Ala Ala Gly Ala Gly 
    130                 135                 140                 


Cys Cys Cys Gly Ala Gly Gly Ala Ala Ala Cys Cys Cys Thr Gly Cys 
145                 150                 155                 160 


Gly Gly Ala Thr Gly Cys Thr Gly Gly Ala Ala Gly Ala Thr Ala Ala 
                165                 170                 175     


Cys Gly Thr Gly Ala Thr Gly Ala Gly Gly Cys Cys Cys Gly Gly Cys 
            180                 185                 190         


Thr Ala Cys Thr Ala Cys Cys Ala Gly Cys Thr Gly Cys Thr Cys Cys 
        195                 200                 205             


Ala Gly Gly Cys Cys Ala Gly Cys Cys Thr Gly Ala Cys Cys Thr Gly 
    210                 215                 220                 


Cys Thr Cys Cys Cys Cys Cys Cys Ala Cys Cys Gly Gly Cys Ala Gly 
225                 230                 235                 240 


Cys Gly Gly Cys Gly Gly Cys Gly Cys Gly Gly Gly Cys Gly Cys Ala 
                245                 250                 255     


Ala Ala Cys Gly Cys Cys Gly Cys Thr Cys Thr Gly Cys Cys Ala Cys 
            260                 265                 270         


Cys Ala Thr Gly Gly Ala Cys Thr Gly Gly Ala Cys Cys Thr Gly Gly 
        275                 280                 285             


Ala Thr Cys Cys Thr Gly Thr Thr Cys Cys Thr Gly Gly Thr Cys Gly 
    290                 295                 300                 


Cys Thr Gly Cys Thr Gly Cys Cys Ala Cys Ala Ala Gly Ala Gly Thr 
305                 310                 315                 320 


Gly Cys Ala Cys Ala Gly Cys Ala Gly Cys Ala Cys Cys Ala Ala Gly 
                325                 330                 335     


Gly Ala Cys Ala Ala Cys Thr Thr Cys Ala Ala Cys Gly Thr Gly Thr 
            340                 345                 350         


Ala Cys Ala Ala Gly Gly Cys Cys Ala Cys Cys Cys Gly Gly Cys Cys 
        355                 360                 365             


Cys Thr Ala Cys Cys Thr Gly Gly Cys Cys Cys Ala Cys Thr Gly Cys 
    370                 375                 380                 


Cys Cys Cys Gly Ala Thr Thr Gly Cys Gly Gly Cys Gly Ala Gly Gly 
385                 390                 395                 400 


Gly Cys Cys Ala Cys Ala Gly Cys Thr Gly Cys Cys Ala Cys Ala Gly 
                405                 410                 415     


Cys Cys Cys Cys Gly Thr Gly Gly Cys Cys Cys Thr Gly Gly Ala Ala 
            420                 425                 430         


Cys Gly Gly Ala Thr Cys Cys Gly Gly Ala Ala Cys Gly Ala Gly Gly 
        435                 440                 445             


Cys Cys Ala Cys Cys Gly Ala Cys Gly Gly Cys Ala Cys Cys Cys Thr 
    450                 455                 460                 


Gly Ala Ala Gly Ala Thr Cys Cys Ala Gly Gly Thr Gly Thr Cys Cys 
465                 470                 475                 480 


Cys Thr Gly Cys Ala Gly Ala Thr Cys Gly Gly Cys Ala Thr Cys Ala 
                485                 490                 495     


Ala Gly Ala Cys Cys Gly Ala Cys Gly Ala Cys Ala Gly Cys Cys Ala 
            500                 505                 510         


Cys Gly Ala Cys Thr Gly Gly Ala Cys Cys Ala Ala Gly Cys Thr Gly 
        515                 520                 525             


Cys Gly Gly Thr Ala Cys Ala Thr Gly Gly Ala Cys Ala Ala Cys Cys 
    530                 535                 540                 


Ala Cys Ala Thr Gly Cys Cys Cys Gly Cys Cys Gly Ala Cys Gly Cys 
545                 550                 555                 560 


Cys Gly Ala Gly Ala Gly Ala Gly Cys Cys Gly Gly Cys Cys Thr Gly 
                565                 570                 575     


Thr Thr Cys Gly Thr Cys Cys Gly Gly Ala Cys Cys Ala Gly Cys Gly 
            580                 585                 590         


Cys Cys Cys Cys Cys Thr Gly Cys Ala Cys Cys Ala Thr Cys Ala Cys 
        595                 600                 605             


Cys Gly Gly Cys Ala Cys Cys Ala Thr Gly Gly Gly Cys Cys Ala Cys 
    610                 615                 620                 


Thr Thr Cys Ala Thr Cys Cys Thr Gly Gly Cys Cys Cys Gly Gly Thr 
625                 630                 635                 640 


Gly Cys Cys Cys Cys Ala Ala Gly Gly Gly Cys Gly Ala Gly Ala Cys 
                645                 650                 655     


Ala Cys Thr Gly Ala Cys Cys Gly Thr Gly Gly Gly Cys Thr Thr Cys 
            660                 665                 670         


Ala Cys Cys Gly Ala Cys Ala Gly Cys Cys Gly Gly Ala Ala Gly Ala 
        675                 680                 685             


Thr Cys Ala Gly Cys Cys Ala Cys Thr Cys Cys Thr Gly Cys Ala Cys 
    690                 695                 700                 


Cys Cys Ala Cys Cys Cys Cys Thr Thr Cys Cys Ala Cys Cys Ala Cys 
705                 710                 715                 720 


Gly Ala Cys Cys Cys Cys Cys Cys Cys Gly Thr Gly Ala Thr Cys Gly 
                725                 730                 735     


Gly Cys Cys Gly Gly Gly Ala Gly Ala Ala Gly Thr Thr Cys Cys Ala 
            740                 745                 750         


Cys Ala Gly Cys Ala Gly Gly Cys Cys Cys Cys Ala Gly Cys Ala Cys 
        755                 760                 765             


Gly Gly Cys Ala Ala Ala Gly Ala Gly Cys Thr Gly Cys Cys Cys Thr 
    770                 775                 780                 


Gly Cys Ala Gly Cys Ala Cys Cys Thr Ala Cys Gly Thr Gly Cys Ala 
785                 790                 795                 800 


Gly Ala Gly Cys Ala Cys Cys Gly Cys Cys Gly Cys Cys Ala Cys Ala 
                805                 810                 815     


Ala Cys Cys Gly Ala Gly Gly Ala Ala Ala Thr Cys Gly Ala Gly Gly 
            820                 825                 830         


Thr Gly Cys Ala Cys Ala Thr Gly Cys Cys Cys Cys Cys Cys Gly Ala 
        835                 840                 845             


Thr Ala Cys Cys Cys Cys Cys Gly Ala Cys Cys Gly Gly Ala Cys Cys 
    850                 855                 860                 


Cys Thr Gly Ala Thr Gly Ala Gly Cys Cys Ala Gly Cys Ala Gly Ala 
865                 870                 875                 880 


Gly Cys Gly Gly Cys Ala Ala Cys Gly Thr Gly Ala Ala Gly Ala Thr 
                885                 890                 895     


Cys Ala Cys Cys Gly Thr Gly Ala Ala Cys Gly Gly Cys Cys Ala Gly 
            900                 905                 910         


Ala Cys Cys Gly Thr Gly Cys Gly Gly Thr Ala Cys Ala Ala Gly Thr 
        915                 920                 925             


Gly Cys Ala Ala Cys Thr Gly Cys Gly Gly Cys Gly Gly Cys Ala Gly 
    930                 935                 940                 


Cys Ala Ala Cys Gly Ala Gly Gly Gly Cys Cys Thr Gly Ala Cys Cys 
945                 950                 955                 960 


Ala Cys Cys Ala Cys Cys Gly Ala Cys Ala Ala Gly Gly Thr Gly Ala 
                965                 970                 975     


Thr Cys Ala Ala Cys Ala Ala Cys Thr Gly Cys Ala Ala Gly Gly Thr 
            980                 985                 990         


Gly Gly Ala Cys Cys Ala Gly Thr  Gly Cys Cys Ala Cys  Gly Cys Cys 
        995                 1000                 1005             


Gly Cys  Cys Gly Thr Gly Ala  Cys Cys Ala Ala Cys  Cys Ala Cys 
    1010                 1015                 1020             


Ala Ala  Gly Ala Ala Gly Thr  Gly Gly Cys Ala Gly  Thr Ala Cys 
    1025                 1030                 1035             


Ala Ala  Cys Ala Gly Cys Cys  Cys Cys Cys Thr Gly  Gly Thr Gly 
    1040                 1045                 1050             


Cys Cys  Cys Cys Gly Gly Ala  Ala Thr Gly Cys Cys  Gly Ala Gly 
    1055                 1060                 1065             


Cys Thr  Gly Gly Gly Cys Gly  Ala Cys Cys Gly Gly  Ala Ala Gly 
    1070                 1075                 1080             


Gly Gly  Cys Ala Ala Gly Ala  Thr Cys Cys Ala Cys  Ala Thr Cys 
    1085                 1090                 1095             


Cys Cys  Cys Thr Thr Cys Cys  Cys Cys Cys Thr Gly  Gly Cys Cys 
    1100                 1105                 1110             


Ala Ala  Cys Gly Thr Gly Ala  Cys Cys Thr Gly Cys  Cys Gly Gly 
    1115                 1120                 1125             


Gly Thr  Gly Cys Cys Cys Ala  Ala Gly Gly Cys Cys  Cys Gly Gly 
    1130                 1135                 1140             


Ala Ala  Cys Cys Cys Cys Ala  Cys Cys Gly Thr Gly  Ala Cys Cys 
    1145                 1150                 1155             


Thr Ala  Cys Gly Gly Cys Ala  Ala Gly Ala Ala Cys  Cys Ala Gly 
    1160                 1165                 1170             


Gly Thr  Gly Ala Thr Cys Ala  Thr Gly Cys Thr Gly  Cys Thr Gly 
    1175                 1180                 1185             


Thr Ala  Cys Cys Cys Cys Gly  Ala Cys Cys Ala Cys  Cys Cys Cys 
    1190                 1195                 1200             


Ala Cys  Cys Cys Thr Gly Cys  Thr Gly Thr Cys Cys  Thr Ala Cys 
    1205                 1210                 1215             


Cys Gly  Gly Ala Ala Cys Ala  Thr Gly Gly Gly Cys  Gly Ala Gly 
    1220                 1225                 1230             


Gly Ala  Ala Cys Cys Cys Ala  Ala Cys Thr Ala Cys  Cys Ala Ala 
    1235                 1240                 1245             


Gly Ala  Gly Gly Ala Gly Thr  Gly Gly Gly Thr Cys  Ala Thr Gly 
    1250                 1255                 1260             


Cys Ala  Cys Ala Ala Gly Ala  Ala Ala Gly Ala Ala  Gly Thr Gly 
    1265                 1270                 1275             


Gly Thr  Gly Cys Thr Gly Ala  Cys Cys Gly Thr Cys  Cys Cys Cys 
    1280                 1285                 1290             


Ala Cys  Cys Gly Ala Gly Gly  Gly Cys Cys Thr Gly  Gly Ala Ala 
    1295                 1300                 1305             


Gly Thr  Gly Ala Cys Cys Thr  Gly Gly Gly Gly Cys  Ala Ala Cys 
    1310                 1315                 1320             


Ala Ala  Cys Gly Ala Gly Cys  Cys Cys Thr Ala Cys  Ala Ala Gly 
    1325                 1330                 1335             


Thr Ala  Cys Thr Gly Gly Cys  Cys Cys Cys Ala Gly  Cys Thr Gly 
    1340                 1345                 1350             


Thr Cys  Cys Ala Cys Cys Ala  Ala Cys Gly Gly Cys  Ala Cys Cys 
    1355                 1360                 1365             


Gly Cys  Cys Cys Ala Cys Gly  Gly Cys Cys Ala Cys  Cys Cys Cys 
    1370                 1375                 1380             


Cys Ala  Cys Gly Ala Gly Ala  Thr Cys Ala Thr Cys  Cys Thr Gly 
    1385                 1390                 1395             


Thr Ala  Cys Thr Ala Cys Thr  Ala Cys Gly Ala Gly  Cys Thr Gly 
    1400                 1405                 1410             


Thr Ala  Cys Cys Cys Thr Ala  Cys Cys Ala Thr Gly  Ala Cys Cys 
    1415                 1420                 1425             


Gly Thr  Gly Gly Thr Gly Gly  Thr Gly Gly Thr Gly  Thr Cys Cys 
    1430                 1435                 1440             


Gly Thr  Gly Gly Cys Cys Ala  Cys Cys Thr Thr Thr  Ala Thr Cys 
    1445                 1450                 1455             


Cys Thr  Gly Cys Thr Gly Thr  Cys Cys Ala Thr Gly  Gly Thr Cys 
    1460                 1465                 1470             


Gly Gly  Cys Ala Thr Gly Gly  Cys Cys Gly Cys Thr  Gly Gly Cys 
    1475                 1480                 1485             


Ala Thr  Gly Thr Gly Cys Ala  Thr Gly Thr Gly Cys  Gly Cys Cys 
    1490                 1495                 1500             


Ala Gly  Gly Ala Gly Gly Cys  Gly Cys Thr Gly Thr  Ala Thr Cys 
    1505                 1510                 1515             


Ala Cys  Cys Cys Cys Cys Thr  Ala Cys Gly Ala Gly  Cys Thr Gly 
    1520                 1525                 1530             


Ala Cys  Ala Cys Cys Thr Gly  Gly Cys Gly Cys Cys  Ala Cys Cys 
    1535                 1540                 1545             


Gly Thr  Gly Cys Cys Cys Thr  Thr Thr Cys Thr Gly  Cys Thr Gly 
    1550                 1555                 1560             


Thr Cys  Cys Cys Thr Gly Ala  Thr Cys Thr Gly Cys  Thr Gly Cys 
    1565                 1570                 1575             


Ala Thr  Cys Cys Gly Gly Ala  Cys Cys Gly Cys Cys  Ala Ala Gly 
    1580                 1585                 1590             


Gly Cys  Cys Cys Gly Cys Gly  Gly Gly Cys Gly Cys  Ala Ala Ala 
    1595                 1600                 1605             


Cys Gly  Cys Cys Gly Cys Thr  Cys Thr Gly Cys Cys  Ala Cys Cys 
    1610                 1615                 1620             


Ala Thr  Gly Gly Ala Cys Thr  Gly Gly Ala Cys Cys  Thr Gly Gly 
    1625                 1630                 1635             


Ala Thr  Cys Cys Thr Gly Thr  Thr Thr Cys Thr Gly  Gly Thr Cys 
    1640                 1645                 1650             


Gly Cys  Thr Gly Cys Thr Gly  Cys Cys Ala Cys Cys  Cys Gly Gly 
    1655                 1660                 1665             


Gly Thr  Gly Cys Ala Cys Ala  Gly Cys Thr Ala Cys  Gly Ala Gly 
    1670                 1675                 1680             


Cys Ala  Cys Gly Thr Gly Ala  Cys Cys Gly Thr Gly  Ala Thr Cys 
    1685                 1690                 1695             


Cys Cys  Cys Ala Ala Cys Ala  Cys Cys Gly Thr Gly  Gly Gly Cys 
    1700                 1705                 1710             


Gly Thr  Gly Cys Cys Cys Thr  Ala Cys Ala Ala Gly  Ala Cys Cys 
    1715                 1720                 1725             


Cys Thr  Gly Gly Thr Gly Ala  Ala Cys Ala Gly Gly  Cys Cys Cys 
    1730                 1735                 1740             


Gly Gly  Cys Thr Ala Cys Ala  Gly Cys Cys Cys Cys  Ala Thr Gly 
    1745                 1750                 1755             


Gly Thr  Gly Cys Thr Gly Gly  Ala Ala Ala Thr Gly  Gly Ala Ala 
    1760                 1765                 1770             


Cys Thr  Gly Cys Thr Gly Thr  Cys Cys Gly Thr Gly  Ala Cys Cys 
    1775                 1780                 1785             


Cys Thr  Gly Gly Ala Ala Cys  Cys Cys Ala Cys Cys  Cys Thr Gly 
    1790                 1795                 1800             


Ala Gly  Cys Cys Thr Gly Gly  Ala Cys Thr Ala Cys  Ala Thr Cys 
    1805                 1810                 1815             


Ala Cys  Cys Thr Gly Cys Gly  Ala Gly Thr Ala Cys  Ala Ala Gly 
    1820                 1825                 1830             


Ala Cys  Ala Gly Thr Gly Ala  Thr Cys Cys Cys Cys  Ala Gly Cys 
    1835                 1840                 1845             


Cys Cys  Cys Thr Ala Cys Gly  Thr Gly Ala Ala Gly  Thr Gly Cys 
    1850                 1855                 1860             


Thr Gly  Cys Gly Gly Cys Ala  Cys Cys Gly Cys Cys  Gly Ala Gly 
    1865                 1870                 1875             


Thr Gly  Cys Ala Ala Gly Gly  Ala Cys Ala Ala Gly  Ala Ala Cys 
    1880                 1885                 1890             


Cys Thr  Gly Cys Cys Cys Gly  Ala Cys Thr Ala Cys  Ala Gly Cys 
    1895                 1900                 1905             


Thr Gly  Cys Ala Ala Gly Gly  Thr Gly Thr Thr Cys  Ala Cys Cys 
    1910                 1915                 1920             


Gly Gly  Cys Gly Thr Gly Thr  Ala Cys Cys Cys Cys  Thr Thr Cys 
    1925                 1930                 1935             


Ala Thr  Gly Thr Gly Gly Gly  Gly Cys Gly Gly Ala  Gly Cys Cys 
    1940                 1945                 1950             


Thr Ala  Cys Thr Gly Cys Thr  Thr Cys Thr Gly Cys  Gly Ala Cys 
    1955                 1960                 1965             


Gly Cys  Cys Gly Ala Gly Ala  Ala Cys Ala Cys Cys  Cys Ala Gly 
    1970                 1975                 1980             


Cys Thr  Gly Thr Cys Cys Gly  Ala Gly Gly Cys Cys  Cys Ala Cys 
    1985                 1990                 1995             


Gly Thr  Gly Gly Ala Gly Ala  Ala Gly Ala Gly Cys  Gly Ala Gly 
    2000                 2005                 2010             


Ala Gly  Cys Thr Gly Cys Ala  Ala Gly Ala Cys Cys  Gly Ala Gly 
    2015                 2020                 2025             


Thr Thr  Cys Gly Cys Cys Ala  Gly Cys Gly Cys Cys  Thr Ala Cys 
    2030                 2035                 2040             


Cys Gly  Gly Gly Cys Cys Cys  Ala Cys Ala Cys Ala  Gly Cys Cys 
    2045                 2050                 2055             


Ala Gly  Cys Gly Cys Cys Ala  Gly Cys Gly Cys Cys  Ala Ala Gly 
    2060                 2065                 2070             


Cys Thr  Gly Cys Gly Gly Gly  Thr Gly Cys Thr Gly  Thr Ala Cys 
    2075                 2080                 2085             


Cys Ala  Gly Gly Gly Cys Ala  Ala Cys Ala Ala Cys  Ala Thr Cys 
    2090                 2095                 2100             


Ala Cys  Cys Gly Thr Gly Ala  Cys Cys Gly Cys Cys  Thr Ala Cys 
    2105                 2110                 2115             


Gly Cys  Cys Ala Ala Cys Gly  Gly Cys Gly Ala Cys  Cys Ala Cys 
    2120                 2125                 2130             


Gly Cys  Cys Gly Thr Gly Ala  Cys Ala Gly Thr Gly  Ala Ala Gly 
    2135                 2140                 2145             


Gly Ala  Cys Gly Cys Cys Ala  Ala Gly Thr Thr Cys  Ala Thr Cys 
    2150                 2155                 2160             


Gly Thr  Gly Gly Gly Cys Cys  Cys Cys Ala Thr Gly  Ala Gly Cys 
    2165                 2170                 2175             


Ala Gly  Cys Gly Cys Cys Thr  Gly Gly Ala Cys Cys  Cys Cys Cys 
    2180                 2185                 2190             


Thr Thr  Cys Gly Ala Cys Ala  Ala Cys Ala Ala Gly  Ala Thr Cys 
    2195                 2200                 2205             


Gly Thr  Gly Gly Thr Gly Thr  Ala Cys Ala Ala Gly  Gly Gly Cys 
    2210                 2215                 2220             


Gly Ala  Cys Gly Thr Gly Thr  Ala Cys Ala Ala Cys  Ala Thr Gly 
    2225                 2230                 2235             


Gly Ala  Cys Thr Ala Cys Cys  Cys Cys Cys Cys Cys  Thr Thr Cys 
    2240                 2245                 2250             


Gly Gly  Ala Gly Cys Cys Gly  Gly Cys Ala Gly Ala  Cys Cys Cys 
    2255                 2260                 2265             


Gly Gly  Cys Cys Ala Gly Thr  Thr Cys Gly Gly Cys  Gly Ala Cys 
    2270                 2275                 2280             


Ala Thr  Cys Cys Ala Gly Ala  Gly Cys Cys Gly Gly  Ala Cys Cys 
    2285                 2290                 2295             


Cys Cys  Cys Gly Ala Gly Ala  Gly Cys Ala Ala Gly  Gly Ala Cys 
    2300                 2305                 2310             


Gly Thr  Gly Thr Ala Cys Gly  Cys Cys Ala Ala Thr  Ala Cys Cys 
    2315                 2320                 2325             


Cys Ala  Gly Cys Thr Gly Gly  Thr Gly Cys Thr Gly  Cys Ala Gly 
    2330                 2335                 2340             


Ala Gly  Ala Cys Cys Cys Gly  Cys Cys Gly Thr Gly  Gly Gly Cys 
    2345                 2350                 2355             


Ala Cys  Cys Gly Thr Gly Cys  Ala Cys Gly Thr Gly  Cys Cys Thr 
    2360                 2365                 2370             


Thr Ala  Cys Ala Gly Cys Cys  Ala Gly Gly Cys Cys  Cys Cys Cys 
    2375                 2380                 2385             


Ala Gly  Cys Gly Gly Cys Thr  Thr Cys Ala Ala Gly  Thr Ala Cys 
    2390                 2395                 2400             


Thr Gly  Gly Cys Thr Gly Ala  Ala Ala Gly Ala Gly  Ala Gly Gly 
    2405                 2410                 2415             


Gly Gly  Cys Gly Cys Cys Ala  Gly Cys Cys Thr Gly  Cys Ala Gly 
    2420                 2425                 2430             


Cys Ala  Cys Ala Cys Cys Gly  Cys Cys Cys Cys Cys  Thr Thr Cys 
    2435                 2440                 2445             


Gly Gly  Cys Thr Gly Cys Cys  Ala Gly Ala Thr Cys  Gly Cys Cys 
    2450                 2455                 2460             


Ala Cys  Cys Ala Ala Cys Cys  Cys Cys Gly Thr Gly  Cys Gly Gly 
    2465                 2470                 2475             


Gly Cys  Cys Gly Thr Gly Ala  Ala Thr Thr Gly Thr  Gly Cys Cys 
    2480                 2485                 2490             


Gly Thr  Gly Gly Gly Cys Ala  Ala Cys Ala Thr Gly  Cys Cys Cys 
    2495                 2500                 2505             


Ala Thr  Cys Ala Gly Cys Ala  Thr Cys Gly Ala Cys  Ala Thr Cys 
    2510                 2515                 2520             


Cys Cys  Cys Gly Ala Gly Gly  Cys Cys Gly Cys Cys  Thr Thr Cys 
    2525                 2530                 2535             


Ala Cys  Cys Ala Gly Gly Gly  Thr Gly Gly Thr Gly  Gly Ala Cys 
    2540                 2545                 2550             


Gly Cys  Cys Cys Cys Cys Ala  Gly Cys Cys Thr Gly  Ala Cys Cys 
    2555                 2560                 2565             


Gly Ala  Cys Ala Thr Gly Ala  Gly Cys Thr Gly Cys  Gly Ala Gly 
    2570                 2575                 2580             


Gly Thr  Gly Cys Cys Cys Gly  Cys Cys Thr Gly Cys  Ala Cys Cys 
    2585                 2590                 2595             


Cys Ala  Cys Ala Gly Cys Ala  Gly Cys Gly Ala Cys  Thr Thr Cys 
    2600                 2605                 2610             


Gly Gly  Cys Gly Gly Cys Gly  Thr Gly Gly Cys Cys  Ala Thr Cys 
    2615                 2620                 2625             


Ala Thr  Cys Ala Ala Gly Thr  Ala Cys Gly Cys Cys  Gly Cys Cys 
    2630                 2635                 2640             


Ala Gly  Cys Ala Ala Gly Ala  Ala Ala Gly Gly Cys  Ala Ala Gly 
    2645                 2650                 2655             


Thr Gly  Cys Gly Cys Cys Gly  Thr Gly Cys Ala Cys  Ala Gly Cys 
    2660                 2665                 2670             


Ala Thr  Gly Ala Cys Cys Ala  Ala Thr Gly Cys Cys  Gly Thr Gly 
    2675                 2680                 2685             


Ala Cys  Cys Ala Thr Cys Cys  Gly Gly Gly Ala Gly  Gly Cys Cys 
    2690                 2695                 2700             


Gly Ala  Gly Ala Thr Cys Gly  Ala Gly Gly Thr Gly  Gly Ala Gly 
    2705                 2710                 2715             


Gly Gly  Cys Ala Ala Cys Ala  Gly Cys Cys Ala Gly  Cys Thr Gly 
    2720                 2725                 2730             


Cys Ala  Gly Ala Thr Cys Ala  Gly Cys Thr Thr Cys  Ala Gly Cys 
    2735                 2740                 2745             


Ala Cys  Cys Gly Cys Cys Cys  Thr Gly Gly Cys Cys  Ala Gly Cys 
    2750                 2755                 2760             


Gly Cys  Cys Gly Ala Gly Thr  Thr Cys Cys Gly Gly  Gly Thr Gly 
    2765                 2770                 2775             


Cys Ala  Gly Gly Thr Cys Thr  Gly Cys Ala Gly Cys  Ala Cys Cys 
    2780                 2785                 2790             


Cys Ala  Gly Gly Thr Gly Cys  Ala Cys Thr Gly Thr  Gly Cys Cys 
    2795                 2800                 2805             


Gly Cys  Cys Gly Ala Gly Thr  Gly Thr Cys Ala Cys  Cys Cys Cys 
    2810                 2815                 2820             


Cys Cys  Cys Ala Ala Gly Gly  Ala Cys Cys Ala Cys  Ala Thr Cys 
    2825                 2830                 2835             


Gly Thr  Gly Ala Ala Cys Thr  Ala Cys Cys Cys Cys  Gly Cys Cys 
    2840                 2845                 2850             


Ala Gly  Cys Cys Ala Cys Ala  Cys Cys Ala Cys Cys  Cys Thr Gly 
    2855                 2860                 2865             


Gly Gly  Cys Gly Thr Gly Cys  Ala Gly Gly Ala Cys  Ala Thr Cys 
    2870                 2875                 2880             


Ala Gly  Cys Gly Cys Cys Ala  Cys Cys Gly Cys Cys  Ala Thr Gly 
    2885                 2890                 2895             


Ala Gly  Cys Thr Gly Gly Gly  Thr Gly Cys Ala Gly  Ala Ala Gly 
    2900                 2905                 2910             


Ala Thr  Cys Ala Cys Ala Gly  Gly Cys Gly Gly Cys  Gly Thr Cys 
    2915                 2920                 2925             


Gly Gly  Cys Cys Thr Gly Gly  Thr Gly Gly Thr Gly  Gly Cys Cys 
    2930                 2935                 2940             


Gly Thr  Gly Gly Cys Cys Gly  Cys Cys Cys Thr Gly  Ala Thr Cys 
    2945                 2950                 2955             


Cys Thr  Gly Ala Thr Cys Gly  Thr Gly Gly Thr Gly  Cys Thr Gly 
    2960                 2965                 2970             


Thr Gly  Cys Gly Thr Gly Ala  Gly Cys Thr Thr Cys  Ala Gly Cys 
    2975                 2980                 2985             


Cys Gly  Gly Cys Ala Cys Thr  Gly Ala Thr Gly Ala  Gly Cys Gly 
    2990                 2995                 3000             


Gly Cys  Cys Gly Cys 
    3005             


<210>  14
<211>  998
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHIKV Env consensus

<400>  14

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Leu Ala Ile Pro Val Met Cys Leu Leu Ala Asn Thr Thr 
            20                  25                  30          


Phe Pro Cys Ser Gln Pro Pro Cys Thr Pro Cys Cys Tyr Glu Lys Glu 
        35                  40                  45              


Pro Glu Glu Thr Leu Arg Met Leu Glu Asp Asn Val Met Arg Pro Gly 
    50                  55                  60                  


Tyr Tyr Gln Leu Leu Gln Ala Ser Leu Thr Cys Ser Pro His Arg Gln 
65                  70                  75                  80  


Arg Arg Arg Gly Arg Lys Arg Arg Ser Ala Thr Met Asp Trp Thr Trp 
                85                  90                  95      


Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val His Ser Ser Thr Lys 
            100                 105                 110         


Asp Asn Phe Asn Val Tyr Lys Ala Thr Arg Pro Tyr Leu Ala His Cys 
        115                 120                 125             


Pro Asp Cys Gly Glu Gly His Ser Cys His Ser Pro Val Ala Leu Glu 
    130                 135                 140                 


Arg Ile Arg Asn Glu Ala Thr Asp Gly Thr Leu Lys Ile Gln Val Ser 
145                 150                 155                 160 


Leu Gln Ile Gly Ile Lys Thr Asp Asp Ser His Asp Trp Thr Lys Leu 
                165                 170                 175     


Arg Tyr Met Asp Asn His Met Pro Ala Asp Ala Glu Arg Ala Gly Leu 
            180                 185                 190         


Phe Val Arg Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr Met Gly His 
        195                 200                 205             


Phe Ile Leu Ala Arg Cys Pro Lys Gly Glu Thr Leu Thr Val Gly Phe 
    210                 215                 220                 


Thr Asp Ser Arg Lys Ile Ser His Ser Cys Thr His Pro Phe His His 
225                 230                 235                 240 


Asp Pro Pro Val Ile Gly Arg Glu Lys Phe His Ser Arg Pro Gln His 
                245                 250                 255     


Gly Lys Glu Leu Pro Cys Ser Thr Tyr Val Gln Ser Thr Ala Ala Thr 
            260                 265                 270         


Thr Glu Glu Ile Glu Val His Met Pro Pro Asp Thr Pro Asp Arg Thr 
        275                 280                 285             


Leu Met Ser Gln Gln Ser Gly Asn Val Lys Ile Thr Val Asn Gly Gln 
    290                 295                 300                 


Thr Val Arg Tyr Lys Cys Asn Cys Gly Gly Ser Asn Glu Gly Leu Thr 
305                 310                 315                 320 


Thr Thr Asp Lys Val Ile Asn Asn Cys Lys Val Asp Gln Cys His Ala 
                325                 330                 335     


Ala Val Thr Asn His Lys Lys Trp Gln Tyr Asn Ser Pro Leu Val Pro 
            340                 345                 350         


Arg Asn Ala Glu Leu Gly Asp Arg Lys Gly Lys Ile His Ile Pro Phe 
        355                 360                 365             


Pro Leu Ala Asn Val Thr Cys Arg Val Pro Lys Ala Arg Asn Pro Thr 
    370                 375                 380                 


Val Thr Tyr Gly Lys Asn Gln Val Ile Met Leu Leu Tyr Pro Asp His 
385                 390                 395                 400 


Pro Thr Leu Leu Ser Tyr Arg Asn Met Gly Glu Glu Pro Asn Tyr Gln 
                405                 410                 415     


Glu Glu Trp Val Met His Lys Lys Glu Val Val Leu Thr Val Pro Thr 
            420                 425                 430         


Glu Gly Leu Glu Val Thr Trp Gly Asn Asn Glu Pro Tyr Lys Tyr Trp 
        435                 440                 445             


Pro Gln Leu Ser Thr Asn Gly Thr Ala His Gly His Pro His Glu Ile 
    450                 455                 460                 


Ile Leu Tyr Tyr Tyr Glu Leu Tyr Pro Thr Met Thr Val Val Val Val 
465                 470                 475                 480 


Ser Val Ala Thr Phe Ile Leu Leu Ser Met Val Gly Met Ala Ala Gly 
                485                 490                 495     


Met Cys Met Cys Ala Arg Arg Arg Cys Ile Thr Pro Tyr Glu Leu Thr 
            500                 505                 510         


Pro Gly Ala Thr Val Pro Phe Leu Leu Ser Leu Ile Cys Cys Ile Arg 
        515                 520                 525             


Thr Ala Lys Ala Arg Gly Arg Lys Arg Arg Ser Ala Thr Met Asp Trp 
    530                 535                 540                 


Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val His Ser Tyr 
545                 550                 555                 560 


Glu His Val Thr Val Ile Pro Asn Thr Val Gly Val Pro Tyr Lys Thr 
                565                 570                 575     


Leu Val Asn Arg Pro Gly Tyr Ser Pro Met Val Leu Glu Met Glu Leu 
            580                 585                 590         


Leu Ser Val Thr Leu Glu Pro Thr Leu Ser Leu Asp Tyr Ile Thr Cys 
        595                 600                 605             


Glu Tyr Lys Thr Val Ile Pro Ser Pro Tyr Val Lys Cys Cys Gly Thr 
    610                 615                 620                 


Ala Glu Cys Lys Asp Lys Asn Leu Pro Asp Tyr Ser Cys Lys Val Phe 
625                 630                 635                 640 


Thr Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Tyr Cys Phe Cys Asp 
                645                 650                 655     


Ala Glu Asn Thr Gln Leu Ser Glu Ala His Val Glu Lys Ser Glu Ser 
            660                 665                 670         


Cys Lys Thr Glu Phe Ala Ser Ala Tyr Arg Ala His Thr Ala Ser Ala 
        675                 680                 685             


Ser Ala Lys Leu Arg Val Leu Tyr Gln Gly Asn Asn Ile Thr Val Thr 
    690                 695                 700                 


Ala Tyr Ala Asn Gly Asp His Ala Val Thr Val Lys Asp Ala Lys Phe 
705                 710                 715                 720 


Ile Val Gly Pro Met Ser Ser Ala Trp Thr Pro Phe Asp Asn Lys Ile 
                725                 730                 735     


Val Val Tyr Lys Gly Asp Val Tyr Asn Met Asp Tyr Pro Pro Phe Gly 
            740                 745                 750         


Ala Gly Arg Pro Gly Gln Phe Gly Asp Ile Gln Ser Arg Thr Pro Glu 
        755                 760                 765             


Ser Lys Asp Val Tyr Ala Asn Thr Gln Leu Val Leu Gln Arg Pro Ala 
    770                 775                 780                 


Val Gly Thr Val His Val Pro Tyr Ser Gln Ala Pro Ser Gly Phe Lys 
785                 790                 795                 800 


Tyr Trp Leu Lys Glu Arg Gly Ala Ser Leu Gln His Thr Ala Pro Phe 
                805                 810                 815     


Gly Cys Gln Ile Ala Thr Asn Pro Val Arg Ala Val Asn Cys Ala Val 
            820                 825                 830         


Gly Asn Met Pro Ile Ser Ile Asp Ile Pro Glu Ala Ala Phe Thr Arg 
        835                 840                 845             


Val Val Asp Ala Pro Ser Leu Thr Asp Met Ser Cys Glu Val Pro Ala 
    850                 855                 860                 


Cys Thr His Ser Ser Asp Phe Gly Gly Val Ala Ile Ile Lys Tyr Ala 
865                 870                 875                 880 


Ala Ser Lys Lys Gly Lys Cys Ala Val His Ser Met Thr Asn Ala Val 
                885                 890                 895     


Thr Ile Arg Glu Ala Glu Ile Glu Val Glu Gly Asn Ser Gln Leu Gln 
            900                 905                 910         


Ile Ser Phe Ser Thr Ala Leu Ala Ser Ala Glu Phe Arg Val Gln Val 
        915                 920                 925             


Cys Ser Thr Gln Val His Cys Ala Ala Glu Cys His Pro Pro Lys Asp 
    930                 935                 940                 


His Ile Val Asn Tyr Pro Ala Ser His Thr Thr Leu Gly Val Gln Asp 
945                 950                 955                 960 


Ile Ser Ala Thr Ala Met Ser Trp Val Gln Lys Ile Thr Gly Gly Val 
                965                 970                 975     


Gly Leu Val Val Ala Val Ala Ala Leu Ile Leu Ile Val Val Leu Cys 
            980                 985                 990         


Val Ser Phe Ser Arg His 
        995             


<210>  15
<211>  2954
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHIKV Env consensus

<400>  15

Ala Gly Cys Cys Thr Gly Gly Cys Cys Ala Thr Cys Cys Cys Cys Gly 
1               5                   10                  15      


Thr Gly Ala Thr Gly Thr Gly Cys Cys Thr Gly Cys Thr Gly Gly Cys 
            20                  25                  30          


Cys Ala Ala Cys Ala Cys Cys Ala Cys Cys Thr Thr Cys Cys Cys Thr 
        35                  40                  45              


Thr Gly Cys Ala Gly Cys Cys Ala Gly Cys Cys Cys Cys Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Cys Cys Cys Cys Cys Thr Gly Cys Thr Gly Cys Thr Ala 
65                  70                  75                  80  


Cys Gly Ala Gly Ala Ala Ala Gly Ala Gly Cys Cys Cys Gly Ala Gly 
                85                  90                  95      


Gly Ala Ala Ala Cys Cys Cys Thr Gly Cys Gly Gly Ala Thr Gly Cys 
            100                 105                 110         


Thr Gly Gly Ala Ala Gly Ala Thr Ala Ala Cys Gly Thr Gly Ala Thr 
        115                 120                 125             


Gly Ala Gly Gly Cys Cys Cys Gly Gly Cys Thr Ala Cys Thr Ala Cys 
    130                 135                 140                 


Cys Ala Gly Cys Thr Gly Cys Thr Cys Cys Ala Gly Gly Cys Cys Ala 
145                 150                 155                 160 


Gly Cys Cys Thr Gly Ala Cys Cys Thr Gly Cys Thr Cys Cys Cys Cys 
                165                 170                 175     


Cys Cys Ala Cys Cys Gly Gly Cys Ala Gly Cys Gly Gly Cys Gly Gly 
            180                 185                 190         


Cys Gly Cys Gly Gly Gly Cys Gly Cys Ala Ala Ala Cys Gly Cys Cys 
        195                 200                 205             


Gly Cys Thr Cys Thr Gly Cys Cys Ala Cys Cys Ala Thr Gly Gly Ala 
    210                 215                 220                 


Cys Thr Gly Gly Ala Cys Cys Thr Gly Gly Ala Thr Cys Cys Thr Gly 
225                 230                 235                 240 


Thr Thr Cys Cys Thr Gly Gly Thr Cys Gly Cys Thr Gly Cys Thr Gly 
                245                 250                 255     


Cys Cys Ala Cys Ala Ala Gly Ala Gly Thr Gly Cys Ala Cys Ala Gly 
            260                 265                 270         


Cys Ala Gly Cys Ala Cys Cys Ala Ala Gly Gly Ala Cys Ala Ala Cys 
        275                 280                 285             


Thr Thr Cys Ala Ala Cys Gly Thr Gly Thr Ala Cys Ala Ala Gly Gly 
    290                 295                 300                 


Cys Cys Ala Cys Cys Cys Gly Gly Cys Cys Cys Thr Ala Cys Cys Thr 
305                 310                 315                 320 


Gly Gly Cys Cys Cys Ala Cys Thr Gly Cys Cys Cys Cys Gly Ala Thr 
                325                 330                 335     


Thr Gly Cys Gly Gly Cys Gly Ala Gly Gly Gly Cys Cys Ala Cys Ala 
            340                 345                 350         


Gly Cys Thr Gly Cys Cys Ala Cys Ala Gly Cys Cys Cys Cys Gly Thr 
        355                 360                 365             


Gly Gly Cys Cys Cys Thr Gly Gly Ala Ala Cys Gly Gly Ala Thr Cys 
    370                 375                 380                 


Cys Gly Gly Ala Ala Cys Gly Ala Gly Gly Cys Cys Ala Cys Cys Gly 
385                 390                 395                 400 


Ala Cys Gly Gly Cys Ala Cys Cys Cys Thr Gly Ala Ala Gly Ala Thr 
                405                 410                 415     


Cys Cys Ala Gly Gly Thr Gly Thr Cys Cys Cys Thr Gly Cys Ala Gly 
            420                 425                 430         


Ala Thr Cys Gly Gly Cys Ala Thr Cys Ala Ala Gly Ala Cys Cys Gly 
        435                 440                 445             


Ala Cys Gly Ala Cys Ala Gly Cys Cys Ala Cys Gly Ala Cys Thr Gly 
    450                 455                 460                 


Gly Ala Cys Cys Ala Ala Gly Cys Thr Gly Cys Gly Gly Thr Ala Cys 
465                 470                 475                 480 


Ala Thr Gly Gly Ala Cys Ala Ala Cys Cys Ala Cys Ala Thr Gly Cys 
                485                 490                 495     


Cys Cys Gly Cys Cys Gly Ala Cys Gly Cys Cys Gly Ala Gly Ala Gly 
            500                 505                 510         


Ala Gly Cys Cys Gly Gly Cys Cys Thr Gly Thr Thr Cys Gly Thr Cys 
        515                 520                 525             


Cys Gly Gly Ala Cys Cys Ala Gly Cys Gly Cys Cys Cys Cys Cys Thr 
    530                 535                 540                 


Gly Cys Ala Cys Cys Ala Thr Cys Ala Cys Cys Gly Gly Cys Ala Cys 
545                 550                 555                 560 


Cys Ala Thr Gly Gly Gly Cys Cys Ala Cys Thr Thr Cys Ala Thr Cys 
                565                 570                 575     


Cys Thr Gly Gly Cys Cys Cys Gly Gly Thr Gly Cys Cys Cys Cys Ala 
            580                 585                 590         


Ala Gly Gly Gly Cys Gly Ala Gly Ala Cys Ala Cys Thr Gly Ala Cys 
        595                 600                 605             


Cys Gly Thr Gly Gly Gly Cys Thr Thr Cys Ala Cys Cys Gly Ala Cys 
    610                 615                 620                 


Ala Gly Cys Cys Gly Gly Ala Ala Gly Ala Thr Cys Ala Gly Cys Cys 
625                 630                 635                 640 


Ala Cys Thr Cys Cys Thr Gly Cys Ala Cys Cys Cys Ala Cys Cys Cys 
                645                 650                 655     


Cys Thr Thr Cys Cys Ala Cys Cys Ala Cys Gly Ala Cys Cys Cys Cys 
            660                 665                 670         


Cys Cys Cys Gly Thr Gly Ala Thr Cys Gly Gly Cys Cys Gly Gly Gly 
        675                 680                 685             


Ala Gly Ala Ala Gly Thr Thr Cys Cys Ala Cys Ala Gly Cys Ala Gly 
    690                 695                 700                 


Gly Cys Cys Cys Cys Ala Gly Cys Ala Cys Gly Gly Cys Ala Ala Ala 
705                 710                 715                 720 


Gly Ala Gly Cys Thr Gly Cys Cys Cys Thr Gly Cys Ala Gly Cys Ala 
                725                 730                 735     


Cys Cys Thr Ala Cys Gly Thr Gly Cys Ala Gly Ala Gly Cys Ala Cys 
            740                 745                 750         


Cys Gly Cys Cys Gly Cys Cys Ala Cys Ala Ala Cys Cys Gly Ala Gly 
        755                 760                 765             


Gly Ala Ala Ala Thr Cys Gly Ala Gly Gly Thr Gly Cys Ala Cys Ala 
    770                 775                 780                 


Thr Gly Cys Cys Cys Cys Cys Cys Gly Ala Thr Ala Cys Cys Cys Cys 
785                 790                 795                 800 


Cys Gly Ala Cys Cys Gly Gly Ala Cys Cys Cys Thr Gly Ala Thr Gly 
                805                 810                 815     


Ala Gly Cys Cys Ala Gly Cys Ala Gly Ala Gly Cys Gly Gly Cys Ala 
            820                 825                 830         


Ala Cys Gly Thr Gly Ala Ala Gly Ala Thr Cys Ala Cys Cys Gly Thr 
        835                 840                 845             


Gly Ala Ala Cys Gly Gly Cys Cys Ala Gly Ala Cys Cys Gly Thr Gly 
    850                 855                 860                 


Cys Gly Gly Thr Ala Cys Ala Ala Gly Thr Gly Cys Ala Ala Cys Thr 
865                 870                 875                 880 


Gly Cys Gly Gly Cys Gly Gly Cys Ala Gly Cys Ala Ala Cys Gly Ala 
                885                 890                 895     


Gly Gly Gly Cys Cys Thr Gly Ala Cys Cys Ala Cys Cys Ala Cys Cys 
            900                 905                 910         


Gly Ala Cys Ala Ala Gly Gly Thr Gly Ala Thr Cys Ala Ala Cys Ala 
        915                 920                 925             


Ala Cys Thr Gly Cys Ala Ala Gly Gly Thr Gly Gly Ala Cys Cys Ala 
    930                 935                 940                 


Gly Thr Gly Cys Cys Ala Cys Gly Cys Cys Gly Cys Cys Gly Thr Gly 
945                 950                 955                 960 


Ala Cys Cys Ala Ala Cys Cys Ala Cys Ala Ala Gly Ala Ala Gly Thr 
                965                 970                 975     


Gly Gly Cys Ala Gly Thr Ala Cys Ala Ala Cys Ala Gly Cys Cys Cys 
            980                 985                 990         


Cys Cys Thr Gly Gly Thr Gly Cys  Cys Cys Cys Gly Gly  Ala Ala Thr 
        995                 1000                 1005             


Gly Cys  Cys Gly Ala Gly Cys  Thr Gly Gly Gly Cys  Gly Ala Cys 
    1010                 1015                 1020             


Cys Gly  Gly Ala Ala Gly Gly  Gly Cys Ala Ala Gly  Ala Thr Cys 
    1025                 1030                 1035             


Cys Ala  Cys Ala Thr Cys Cys  Cys Cys Thr Thr Cys  Cys Cys Cys 
    1040                 1045                 1050             


Cys Thr  Gly Gly Cys Cys Ala  Ala Cys Gly Thr Gly  Ala Cys Cys 
    1055                 1060                 1065             


Thr Gly  Cys Cys Gly Gly Gly  Thr Gly Cys Cys Cys  Ala Ala Gly 
    1070                 1075                 1080             


Gly Cys  Cys Cys Gly Gly Ala  Ala Cys Cys Cys Cys  Ala Cys Cys 
    1085                 1090                 1095             


Gly Thr  Gly Ala Cys Cys Thr  Ala Cys Gly Gly Cys  Ala Ala Gly 
    1100                 1105                 1110             


Ala Ala  Cys Cys Ala Gly Gly  Thr Gly Ala Thr Cys  Ala Thr Gly 
    1115                 1120                 1125             


Cys Thr  Gly Cys Thr Gly Thr  Ala Cys Cys Cys Cys  Gly Ala Cys 
    1130                 1135                 1140             


Cys Ala  Cys Cys Cys Cys Ala  Cys Cys Cys Thr Gly  Cys Thr Gly 
    1145                 1150                 1155             


Thr Cys  Cys Thr Ala Cys Cys  Gly Gly Ala Ala Cys  Ala Thr Gly 
    1160                 1165                 1170             


Gly Gly  Cys Gly Ala Gly Gly  Ala Ala Cys Cys Cys  Ala Ala Cys 
    1175                 1180                 1185             


Thr Ala  Cys Cys Ala Ala Gly  Ala Gly Gly Ala Gly  Thr Gly Gly 
    1190                 1195                 1200             


Gly Thr  Cys Ala Thr Gly Cys  Ala Cys Ala Ala Gly  Ala Ala Ala 
    1205                 1210                 1215             


Gly Ala  Ala Gly Thr Gly Gly  Thr Gly Cys Thr Gly  Ala Cys Cys 
    1220                 1225                 1230             


Gly Thr  Cys Cys Cys Cys Ala  Cys Cys Gly Ala Gly  Gly Gly Cys 
    1235                 1240                 1245             


Cys Thr  Gly Gly Ala Ala Gly  Thr Gly Ala Cys Cys  Thr Gly Gly 
    1250                 1255                 1260             


Gly Gly  Cys Ala Ala Cys Ala  Ala Cys Gly Ala Gly  Cys Cys Cys 
    1265                 1270                 1275             


Thr Ala  Cys Ala Ala Gly Thr  Ala Cys Thr Gly Gly  Cys Cys Cys 
    1280                 1285                 1290             


Cys Ala  Gly Cys Thr Gly Thr  Cys Cys Ala Cys Cys  Ala Ala Cys 
    1295                 1300                 1305             


Gly Gly  Cys Ala Cys Cys Gly  Cys Cys Cys Ala Cys  Gly Gly Cys 
    1310                 1315                 1320             


Cys Ala  Cys Cys Cys Cys Cys  Ala Cys Gly Ala Gly  Ala Thr Cys 
    1325                 1330                 1335             


Ala Thr  Cys Cys Thr Gly Thr  Ala Cys Thr Ala Cys  Thr Ala Cys 
    1340                 1345                 1350             


Gly Ala  Gly Cys Thr Gly Thr  Ala Cys Cys Cys Thr  Ala Cys Cys 
    1355                 1360                 1365             


Ala Thr  Gly Ala Cys Cys Gly  Thr Gly Gly Thr Gly  Gly Thr Gly 
    1370                 1375                 1380             


Gly Thr  Gly Thr Cys Cys Gly  Thr Gly Gly Cys Cys  Ala Cys Cys 
    1385                 1390                 1395             


Thr Thr  Thr Ala Thr Cys Cys  Thr Gly Cys Thr Gly  Thr Cys Cys 
    1400                 1405                 1410             


Ala Thr  Gly Gly Thr Cys Gly  Gly Cys Ala Thr Gly  Gly Cys Cys 
    1415                 1420                 1425             


Gly Cys  Thr Gly Gly Cys Ala  Thr Gly Thr Gly Cys  Ala Thr Gly 
    1430                 1435                 1440             


Thr Gly  Cys Gly Cys Cys Ala  Gly Gly Ala Gly Gly  Cys Gly Cys 
    1445                 1450                 1455             


Thr Gly  Thr Ala Thr Cys Ala  Cys Cys Cys Cys Cys  Thr Ala Cys 
    1460                 1465                 1470             


Gly Ala  Gly Cys Thr Gly Ala  Cys Ala Cys Cys Thr  Gly Gly Cys 
    1475                 1480                 1485             


Gly Cys  Cys Ala Cys Cys Gly  Thr Gly Cys Cys Cys  Thr Thr Thr 
    1490                 1495                 1500             


Cys Thr  Gly Cys Thr Gly Thr  Cys Cys Cys Thr Gly  Ala Thr Cys 
    1505                 1510                 1515             


Thr Gly  Cys Thr Gly Cys Ala  Thr Cys Cys Gly Gly  Ala Cys Cys 
    1520                 1525                 1530             


Gly Cys  Cys Ala Ala Gly Gly  Cys Cys Cys Gly Cys  Gly Gly Gly 
    1535                 1540                 1545             


Cys Gly  Cys Ala Ala Ala Cys  Gly Cys Cys Gly Cys  Thr Cys Thr 
    1550                 1555                 1560             


Gly Cys  Cys Ala Cys Cys Ala  Thr Gly Gly Ala Cys  Thr Gly Gly 
    1565                 1570                 1575             


Ala Cys  Cys Thr Gly Gly Ala  Thr Cys Cys Thr Gly  Thr Thr Thr 
    1580                 1585                 1590             


Cys Thr  Gly Gly Thr Cys Gly  Cys Thr Gly Cys Thr  Gly Cys Cys 
    1595                 1600                 1605             


Ala Cys  Cys Cys Gly Gly Gly  Thr Gly Cys Ala Cys  Ala Gly Cys 
    1610                 1615                 1620             


Thr Ala  Cys Gly Ala Gly Cys  Ala Cys Gly Thr Gly  Ala Cys Cys 
    1625                 1630                 1635             


Gly Thr  Gly Ala Thr Cys Cys  Cys Cys Ala Ala Cys  Ala Cys Cys 
    1640                 1645                 1650             


Gly Thr  Gly Gly Gly Cys Gly  Thr Gly Cys Cys Cys  Thr Ala Cys 
    1655                 1660                 1665             


Ala Ala  Gly Ala Cys Cys Cys  Thr Gly Gly Thr Gly  Ala Ala Cys 
    1670                 1675                 1680             


Ala Gly  Gly Cys Cys Cys Gly  Gly Cys Thr Ala Cys  Ala Gly Cys 
    1685                 1690                 1695             


Cys Cys  Cys Ala Thr Gly Gly  Thr Gly Cys Thr Gly  Gly Ala Ala 
    1700                 1705                 1710             


Ala Thr  Gly Gly Ala Ala Cys  Thr Gly Cys Thr Gly  Thr Cys Cys 
    1715                 1720                 1725             


Gly Thr  Gly Ala Cys Cys Cys  Thr Gly Gly Ala Ala  Cys Cys Cys 
    1730                 1735                 1740             


Ala Cys  Cys Cys Thr Gly Ala  Gly Cys Cys Thr Gly  Gly Ala Cys 
    1745                 1750                 1755             


Thr Ala  Cys Ala Thr Cys Ala  Cys Cys Thr Gly Cys  Gly Ala Gly 
    1760                 1765                 1770             


Thr Ala  Cys Ala Ala Gly Ala  Cys Ala Gly Thr Gly  Ala Thr Cys 
    1775                 1780                 1785             


Cys Cys  Cys Ala Gly Cys Cys  Cys Cys Thr Ala Cys  Gly Thr Gly 
    1790                 1795                 1800             


Ala Ala  Gly Thr Gly Cys Thr  Gly Cys Gly Gly Cys  Ala Cys Cys 
    1805                 1810                 1815             


Gly Cys  Cys Gly Ala Gly Thr  Gly Cys Ala Ala Gly  Gly Ala Cys 
    1820                 1825                 1830             


Ala Ala  Gly Ala Ala Cys Cys  Thr Gly Cys Cys Cys  Gly Ala Cys 
    1835                 1840                 1845             


Thr Ala  Cys Ala Gly Cys Thr  Gly Cys Ala Ala Gly  Gly Thr Gly 
    1850                 1855                 1860             


Thr Thr  Cys Ala Cys Cys Gly  Gly Cys Gly Thr Gly  Thr Ala Cys 
    1865                 1870                 1875             


Cys Cys  Cys Thr Thr Cys Ala  Thr Gly Thr Gly Gly  Gly Gly Cys 
    1880                 1885                 1890             


Gly Gly  Ala Gly Cys Cys Thr  Ala Cys Thr Gly Cys  Thr Thr Cys 
    1895                 1900                 1905             


Thr Gly  Cys Gly Ala Cys Gly  Cys Cys Gly Ala Gly  Ala Ala Cys 
    1910                 1915                 1920             


Ala Cys  Cys Cys Ala Gly Cys  Thr Gly Thr Cys Cys  Gly Ala Gly 
    1925                 1930                 1935             


Gly Cys  Cys Cys Ala Cys Gly  Thr Gly Gly Ala Gly  Ala Ala Gly 
    1940                 1945                 1950             


Ala Gly  Cys Gly Ala Gly Ala  Gly Cys Thr Gly Cys  Ala Ala Gly 
    1955                 1960                 1965             


Ala Cys  Cys Gly Ala Gly Thr  Thr Cys Gly Cys Cys  Ala Gly Cys 
    1970                 1975                 1980             


Gly Cys  Cys Thr Ala Cys Cys  Gly Gly Gly Cys Cys  Cys Ala Cys 
    1985                 1990                 1995             


Ala Cys  Ala Gly Cys Cys Ala  Gly Cys Gly Cys Cys  Ala Gly Cys 
    2000                 2005                 2010             


Gly Cys  Cys Ala Ala Gly Cys  Thr Gly Cys Gly Gly  Gly Thr Gly 
    2015                 2020                 2025             


Cys Thr  Gly Thr Ala Cys Cys  Ala Gly Gly Gly Cys  Ala Ala Cys 
    2030                 2035                 2040             


Ala Ala  Cys Ala Thr Cys Ala  Cys Cys Gly Thr Gly  Ala Cys Cys 
    2045                 2050                 2055             


Gly Cys  Cys Thr Ala Cys Gly  Cys Cys Ala Ala Cys  Gly Gly Cys 
    2060                 2065                 2070             


Gly Ala  Cys Cys Ala Cys Gly  Cys Cys Gly Thr Gly  Ala Cys Ala 
    2075                 2080                 2085             


Gly Thr  Gly Ala Ala Gly Gly  Ala Cys Gly Cys Cys  Ala Ala Gly 
    2090                 2095                 2100             


Thr Thr  Cys Ala Thr Cys Gly  Thr Gly Gly Gly Cys  Cys Cys Cys 
    2105                 2110                 2115             


Ala Thr  Gly Ala Gly Cys Ala  Gly Cys Gly Cys Cys  Thr Gly Gly 
    2120                 2125                 2130             


Ala Cys  Cys Cys Cys Cys Thr  Thr Cys Gly Ala Cys  Ala Ala Cys 
    2135                 2140                 2145             


Ala Ala  Gly Ala Thr Cys Gly  Thr Gly Gly Thr Gly  Thr Ala Cys 
    2150                 2155                 2160             


Ala Ala  Gly Gly Gly Cys Gly  Ala Cys Gly Thr Gly  Thr Ala Cys 
    2165                 2170                 2175             


Ala Ala  Cys Ala Thr Gly Gly  Ala Cys Thr Ala Cys  Cys Cys Cys 
    2180                 2185                 2190             


Cys Cys  Cys Thr Thr Cys Gly  Gly Ala Gly Cys Cys  Gly Gly Cys 
    2195                 2200                 2205             


Ala Gly  Ala Cys Cys Cys Gly  Gly Cys Cys Ala Gly  Thr Thr Cys 
    2210                 2215                 2220             


Gly Gly  Cys Gly Ala Cys Ala  Thr Cys Cys Ala Gly  Ala Gly Cys 
    2225                 2230                 2235             


Cys Gly  Gly Ala Cys Cys Cys  Cys Cys Gly Ala Gly  Ala Gly Cys 
    2240                 2245                 2250             


Ala Ala  Gly Gly Ala Cys Gly  Thr Gly Thr Ala Cys  Gly Cys Cys 
    2255                 2260                 2265             


Ala Ala  Thr Ala Cys Cys Cys  Ala Gly Cys Thr Gly  Gly Thr Gly 
    2270                 2275                 2280             


Cys Thr  Gly Cys Ala Gly Ala  Gly Ala Cys Cys Cys  Gly Cys Cys 
    2285                 2290                 2295             


Gly Thr  Gly Gly Gly Cys Ala  Cys Cys Gly Thr Gly  Cys Ala Cys 
    2300                 2305                 2310             


Gly Thr  Gly Cys Cys Thr Thr  Ala Cys Ala Gly Cys  Cys Ala Gly 
    2315                 2320                 2325             


Gly Cys  Cys Cys Cys Cys Ala  Gly Cys Gly Gly Cys  Thr Thr Cys 
    2330                 2335                 2340             


Ala Ala  Gly Thr Ala Cys Thr  Gly Gly Cys Thr Gly  Ala Ala Ala 
    2345                 2350                 2355             


Gly Ala  Gly Ala Gly Gly Gly  Gly Cys Gly Cys Cys  Ala Gly Cys 
    2360                 2365                 2370             


Cys Thr  Gly Cys Ala Gly Cys  Ala Cys Ala Cys Cys  Gly Cys Cys 
    2375                 2380                 2385             


Cys Cys  Cys Thr Thr Cys Gly  Gly Cys Thr Gly Cys  Cys Ala Gly 
    2390                 2395                 2400             


Ala Thr  Cys Gly Cys Cys Ala  Cys Cys Ala Ala Cys  Cys Cys Cys 
    2405                 2410                 2415             


Gly Thr  Gly Cys Gly Gly Gly  Cys Cys Gly Thr Gly  Ala Ala Thr 
    2420                 2425                 2430             


Thr Gly  Thr Gly Cys Cys Gly  Thr Gly Gly Gly Cys  Ala Ala Cys 
    2435                 2440                 2445             


Ala Thr  Gly Cys Cys Cys Ala  Thr Cys Ala Gly Cys  Ala Thr Cys 
    2450                 2455                 2460             


Gly Ala  Cys Ala Thr Cys Cys  Cys Cys Gly Ala Gly  Gly Cys Cys 
    2465                 2470                 2475             


Gly Cys  Cys Thr Thr Cys Ala  Cys Cys Ala Gly Gly  Gly Thr Gly 
    2480                 2485                 2490             


Gly Thr  Gly Gly Ala Cys Gly  Cys Cys Cys Cys Cys  Ala Gly Cys 
    2495                 2500                 2505             


Cys Thr  Gly Ala Cys Cys Gly  Ala Cys Ala Thr Gly  Ala Gly Cys 
    2510                 2515                 2520             


Thr Gly  Cys Gly Ala Gly Gly  Thr Gly Cys Cys Cys  Gly Cys Cys 
    2525                 2530                 2535             


Thr Gly  Cys Ala Cys Cys Cys  Ala Cys Ala Gly Cys  Ala Gly Cys 
    2540                 2545                 2550             


Gly Ala  Cys Thr Thr Cys Gly  Gly Cys Gly Gly Cys  Gly Thr Gly 
    2555                 2560                 2565             


Gly Cys  Cys Ala Thr Cys Ala  Thr Cys Ala Ala Gly  Thr Ala Cys 
    2570                 2575                 2580             


Gly Cys  Cys Gly Cys Cys Ala  Gly Cys Ala Ala Gly  Ala Ala Ala 
    2585                 2590                 2595             


Gly Gly  Cys Ala Ala Gly Thr  Gly Cys Gly Cys Cys  Gly Thr Gly 
    2600                 2605                 2610             


Cys Ala  Cys Ala Gly Cys Ala  Thr Gly Ala Cys Cys  Ala Ala Thr 
    2615                 2620                 2625             


Gly Cys  Cys Gly Thr Gly Ala  Cys Cys Ala Thr Cys  Cys Gly Gly 
    2630                 2635                 2640             


Gly Ala  Gly Gly Cys Cys Gly  Ala Gly Ala Thr Cys  Gly Ala Gly 
    2645                 2650                 2655             


Gly Thr  Gly Gly Ala Gly Gly  Gly Cys Ala Ala Cys  Ala Gly Cys 
    2660                 2665                 2670             


Cys Ala  Gly Cys Thr Gly Cys  Ala Gly Ala Thr Cys  Ala Gly Cys 
    2675                 2680                 2685             


Thr Thr  Cys Ala Gly Cys Ala  Cys Cys Gly Cys Cys  Cys Thr Gly 
    2690                 2695                 2700             


Gly Cys  Cys Ala Gly Cys Gly  Cys Cys Gly Ala Gly  Thr Thr Cys 
    2705                 2710                 2715             


Cys Gly  Gly Gly Thr Gly Cys  Ala Gly Gly Thr Cys  Thr Gly Cys 
    2720                 2725                 2730             


Ala Gly  Cys Ala Cys Cys Cys  Ala Gly Gly Thr Gly  Cys Ala Cys 
    2735                 2740                 2745             


Thr Gly  Thr Gly Cys Cys Gly  Cys Cys Gly Ala Gly  Thr Gly Thr 
    2750                 2755                 2760             


Cys Ala  Cys Cys Cys Cys Cys  Cys Cys Ala Ala Gly  Gly Ala Cys 
    2765                 2770                 2775             


Cys Ala  Cys Ala Thr Cys Gly  Thr Gly Ala Ala Cys  Thr Ala Cys 
    2780                 2785                 2790             


Cys Cys  Cys Gly Cys Cys Ala  Gly Cys Cys Ala Cys  Ala Cys Cys 
    2795                 2800                 2805             


Ala Cys  Cys Cys Thr Gly Gly  Gly Cys Gly Thr Gly  Cys Ala Gly 
    2810                 2815                 2820             


Gly Ala  Cys Ala Thr Cys Ala  Gly Cys Gly Cys Cys  Ala Cys Cys 
    2825                 2830                 2835             


Gly Cys  Cys Ala Thr Gly Ala  Gly Cys Thr Gly Gly  Gly Thr Gly 
    2840                 2845                 2850             


Cys Ala  Gly Ala Ala Gly Ala  Thr Cys Ala Cys Ala  Gly Gly Cys 
    2855                 2860                 2865             


Gly Gly  Cys Gly Thr Cys Gly  Gly Cys Cys Thr Gly  Gly Thr Gly 
    2870                 2875                 2880             


Gly Thr  Gly Gly Cys Cys Gly  Thr Gly Gly Cys Cys  Gly Cys Cys 
    2885                 2890                 2895             


Cys Thr  Gly Ala Thr Cys Cys  Thr Gly Ala Thr Cys  Gly Thr Gly 
    2900                 2905                 2910             


Gly Thr  Gly Cys Thr Gly Thr  Gly Cys Gly Thr Gly  Ala Gly Cys 
    2915                 2920                 2925             


Thr Thr  Cys Ala Gly Cys Cys  Gly Gly Cys Ala Cys  Thr Gly Ala 
    2930                 2935                 2940             


Thr Gly  Ala Gly Cys Gly Gly  Cys Cys Gly Cys 
    2945                 2950                 


<210>  16
<211>  980
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHIKV Env consensus

<400>  16

Ser Leu Ala Ile Pro Val Met Cys Leu Leu Ala Asn Thr Thr Phe Pro 
1               5                   10                  15      


Cys Ser Gln Pro Pro Cys Thr Pro Cys Cys Tyr Glu Lys Glu Pro Glu 
            20                  25                  30          


Glu Thr Leu Arg Met Leu Glu Asp Asn Val Met Arg Pro Gly Tyr Tyr 
        35                  40                  45              


Gln Leu Leu Gln Ala Ser Leu Thr Cys Ser Pro His Arg Gln Arg Arg 
    50                  55                  60                  


Arg Gly Arg Lys Arg Arg Ser Ala Thr Met Asp Trp Thr Trp Ile Leu 
65                  70                  75                  80  


Phe Leu Val Ala Ala Ala Thr Arg Val His Ser Ser Thr Lys Asp Asn 
                85                  90                  95      


Phe Asn Val Tyr Lys Ala Thr Arg Pro Tyr Leu Ala His Cys Pro Asp 
            100                 105                 110         


Cys Gly Glu Gly His Ser Cys His Ser Pro Val Ala Leu Glu Arg Ile 
        115                 120                 125             


Arg Asn Glu Ala Thr Asp Gly Thr Leu Lys Ile Gln Val Ser Leu Gln 
    130                 135                 140                 


Ile Gly Ile Lys Thr Asp Asp Ser His Asp Trp Thr Lys Leu Arg Tyr 
145                 150                 155                 160 


Met Asp Asn His Met Pro Ala Asp Ala Glu Arg Ala Gly Leu Phe Val 
                165                 170                 175     


Arg Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr Met Gly His Phe Ile 
            180                 185                 190         


Leu Ala Arg Cys Pro Lys Gly Glu Thr Leu Thr Val Gly Phe Thr Asp 
        195                 200                 205             


Ser Arg Lys Ile Ser His Ser Cys Thr His Pro Phe His His Asp Pro 
    210                 215                 220                 


Pro Val Ile Gly Arg Glu Lys Phe His Ser Arg Pro Gln His Gly Lys 
225                 230                 235                 240 


Glu Leu Pro Cys Ser Thr Tyr Val Gln Ser Thr Ala Ala Thr Thr Glu 
                245                 250                 255     


Glu Ile Glu Val His Met Pro Pro Asp Thr Pro Asp Arg Thr Leu Met 
            260                 265                 270         


Ser Gln Gln Ser Gly Asn Val Lys Ile Thr Val Asn Gly Gln Thr Val 
        275                 280                 285             


Arg Tyr Lys Cys Asn Cys Gly Gly Ser Asn Glu Gly Leu Thr Thr Thr 
    290                 295                 300                 


Asp Lys Val Ile Asn Asn Cys Lys Val Asp Gln Cys His Ala Ala Val 
305                 310                 315                 320 


Thr Asn His Lys Lys Trp Gln Tyr Asn Ser Pro Leu Val Pro Arg Asn 
                325                 330                 335     


Ala Glu Leu Gly Asp Arg Lys Gly Lys Ile His Ile Pro Phe Pro Leu 
            340                 345                 350         


Ala Asn Val Thr Cys Arg Val Pro Lys Ala Arg Asn Pro Thr Val Thr 
        355                 360                 365             


Tyr Gly Lys Asn Gln Val Ile Met Leu Leu Tyr Pro Asp His Pro Thr 
    370                 375                 380                 


Leu Leu Ser Tyr Arg Asn Met Gly Glu Glu Pro Asn Tyr Gln Glu Glu 
385                 390                 395                 400 


Trp Val Met His Lys Lys Glu Val Val Leu Thr Val Pro Thr Glu Gly 
                405                 410                 415     


Leu Glu Val Thr Trp Gly Asn Asn Glu Pro Tyr Lys Tyr Trp Pro Gln 
            420                 425                 430         


Leu Ser Thr Asn Gly Thr Ala His Gly His Pro His Glu Ile Ile Leu 
        435                 440                 445             


Tyr Tyr Tyr Glu Leu Tyr Pro Thr Met Thr Val Val Val Val Ser Val 
    450                 455                 460                 


Ala Thr Phe Ile Leu Leu Ser Met Val Gly Met Ala Ala Gly Met Cys 
465                 470                 475                 480 


Met Cys Ala Arg Arg Arg Cys Ile Thr Pro Tyr Glu Leu Thr Pro Gly 
                485                 490                 495     


Ala Thr Val Pro Phe Leu Leu Ser Leu Ile Cys Cys Ile Arg Thr Ala 
            500                 505                 510         


Lys Ala Arg Gly Arg Lys Arg Arg Ser Ala Thr Met Asp Trp Thr Trp 
        515                 520                 525             


Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val His Ser Tyr Glu His 
    530                 535                 540                 


Val Thr Val Ile Pro Asn Thr Val Gly Val Pro Tyr Lys Thr Leu Val 
545                 550                 555                 560 


Asn Arg Pro Gly Tyr Ser Pro Met Val Leu Glu Met Glu Leu Leu Ser 
                565                 570                 575     


Val Thr Leu Glu Pro Thr Leu Ser Leu Asp Tyr Ile Thr Cys Glu Tyr 
            580                 585                 590         


Lys Thr Val Ile Pro Ser Pro Tyr Val Lys Cys Cys Gly Thr Ala Glu 
        595                 600                 605             


Cys Lys Asp Lys Asn Leu Pro Asp Tyr Ser Cys Lys Val Phe Thr Gly 
    610                 615                 620                 


Val Tyr Pro Phe Met Trp Gly Gly Ala Tyr Cys Phe Cys Asp Ala Glu 
625                 630                 635                 640 


Asn Thr Gln Leu Ser Glu Ala His Val Glu Lys Ser Glu Ser Cys Lys 
                645                 650                 655     


Thr Glu Phe Ala Ser Ala Tyr Arg Ala His Thr Ala Ser Ala Ser Ala 
            660                 665                 670         


Lys Leu Arg Val Leu Tyr Gln Gly Asn Asn Ile Thr Val Thr Ala Tyr 
        675                 680                 685             


Ala Asn Gly Asp His Ala Val Thr Val Lys Asp Ala Lys Phe Ile Val 
    690                 695                 700                 


Gly Pro Met Ser Ser Ala Trp Thr Pro Phe Asp Asn Lys Ile Val Val 
705                 710                 715                 720 


Tyr Lys Gly Asp Val Tyr Asn Met Asp Tyr Pro Pro Phe Gly Ala Gly 
                725                 730                 735     


Arg Pro Gly Gln Phe Gly Asp Ile Gln Ser Arg Thr Pro Glu Ser Lys 
            740                 745                 750         


Asp Val Tyr Ala Asn Thr Gln Leu Val Leu Gln Arg Pro Ala Val Gly 
        755                 760                 765             


Thr Val His Val Pro Tyr Ser Gln Ala Pro Ser Gly Phe Lys Tyr Trp 
    770                 775                 780                 


Leu Lys Glu Arg Gly Ala Ser Leu Gln His Thr Ala Pro Phe Gly Cys 
785                 790                 795                 800 


Gln Ile Ala Thr Asn Pro Val Arg Ala Val Asn Cys Ala Val Gly Asn 
                805                 810                 815     


Met Pro Ile Ser Ile Asp Ile Pro Glu Ala Ala Phe Thr Arg Val Val 
            820                 825                 830         


Asp Ala Pro Ser Leu Thr Asp Met Ser Cys Glu Val Pro Ala Cys Thr 
        835                 840                 845             


His Ser Ser Asp Phe Gly Gly Val Ala Ile Ile Lys Tyr Ala Ala Ser 
    850                 855                 860                 


Lys Lys Gly Lys Cys Ala Val His Ser Met Thr Asn Ala Val Thr Ile 
865                 870                 875                 880 


Arg Glu Ala Glu Ile Glu Val Glu Gly Asn Ser Gln Leu Gln Ile Ser 
                885                 890                 895     


Phe Ser Thr Ala Leu Ala Ser Ala Glu Phe Arg Val Gln Val Cys Ser 
            900                 905                 910         


Thr Gln Val His Cys Ala Ala Glu Cys His Pro Pro Lys Asp His Ile 
        915                 920                 925             


Val Asn Tyr Pro Ala Ser His Thr Thr Leu Gly Val Gln Asp Ile Ser 
    930                 935                 940                 


Ala Thr Ala Met Ser Trp Val Gln Lys Ile Thr Gly Gly Val Gly Leu 
945                 950                 955                 960 


Val Val Ala Val Ala Ala Leu Ile Leu Ile Val Val Leu Cys Val Ser 
                965                 970                 975     


Phe Ser Arg His 
            980 


<210>  17
<211>  18
<212>  PRT
<213>  HUMAN

<400>  17

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  18
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Kozak sequence

<400>  18

Gly Cys Cys Gly Cys Cys Ala Cys Cys 
1               5                   


