                         SEQUENCE LISTING

<110>  Muraca, Patrick J.
 
<120>  Biomarkers Panel for Prediction of Recurrent Colon Cancer

<130>  NUC-010-PCT

<140>  Not Assigned Yet
<141>  2008-03-17

<160>  24    

<170>  PatentIn version 3.4

<210>  1
<211>  2554
<212>  DNA
<213>  Homo sapiens

<400>  1
acaaggcagc ctcgctcgag cgcaggccaa tcggctttct agctagaggg tttaactcct     60

atttaaaaag aagaaccttt gaattctaac ggctgagctc ttggaagact tgggtccttg    120

ggtcgcaggt gggagccgac gggtgggtag accgtggggg atatctcagt ggcggacgag    180

gacggcgggg acaaggggcg gctggtcgga gtggcggagc gtcaagtccc ctgtcggttc    240

ctccgtccct gagtgtcctt ggcgctgcct tgtgcccgcc cagcgccttt gcatccgctc    300

ctgggcaccg aggcgccctg taggatactg cttgttactt attacagcta gagggtctca    360

ctccattgcc caggccagag tgcggggata tttgataaga aacttcagtg aaggccgggc    420

gcggtggctc atgcccgtaa tcccagcatt ttcggaggcc gaggctggag tgcaatggtg    480

tgatctcagc tcactgcaac ctctgcttcc tgggtttaag tgattctcct gcctcagcct    540

cccgagtagc tgggattaca ggcatcatgg accgatctaa agaaaactgc atttcaggac    600

ctgttaaggc tacagctcca gttggaggtc caaaacgtgt tctcgtgact cagcaatttc    660

cttgtcagaa tccattacct gtaaatagtg gccaggctca gcgggtcttg tgtccttcaa    720

attcttccca gcgcattcct ttgcaagcac aaaagcttgt ctccagtcac aagccggttc    780

agaatcagaa gcagaagcaa ttgcaggcaa ccagtgtacc tcatcctgtc tccaggccac    840

tgaataacac ccaaaagagc aagcagcccc tgccatcggc acctgaaaat aatcctgagg    900

aggaactggc atcaaaacag aaaaatgaag aatcaaaaaa gaggcagtgg gctttggaag    960

actttgaaat tggtcgccct ctgggtaaag gaaagtttgg taatgtttat ttggcaagag   1020

aaaagcaaag caagtttatt ctggctctta aagtgttatt taaagctcag ctggagaaag   1080

ccggagtgga gcatcagctc agaagagaag tagaaataca gtcccacctt cggcatccta   1140

atattcttag actgtatggt tatttccatg atgctaccag agtctaccta attctggaat   1200

atgcaccact tggaacagtt tatagagaac ttcagaaact ttcaaagttt gatgagcaga   1260

gaactgctac ttatataaca gaattggcaa atgccctgtc ttactgtcat tcgaagagag   1320

ttattcatag agacattaag ccagagaact tacttcttgg atcagctgga gagcttaaaa   1380

ttgcagattt tgggtggtca gtacatgctc catcttccag gaggaccact ctctgtggca   1440

ccctggacta cctgccccct gaaatgattg aaggtcggat gcatgatgag aaggtggatc   1500

tctggagcct tggagttctt tgctatgaat ttttagttgg gaagcctcct tttgaggcaa   1560

acacatacca agagacctac aaaagaatat cacgggttga attcacattc cctgactttg   1620

taacagaggg agccagggac ctcatttcaa gactgttgaa gcataatccc agccagaggc   1680

caatgctcag agaagtactt gaacacccct ggatcacagc aaattcatca aaaccatcaa   1740

attgccaaaa caaagaatca gctagcaaac agtcttagga atcgtgcagg gggagaaatc   1800

cttgagccag ggctgccata taacctgaca ggaacatgct actgaagttt attttaccat   1860

tgactgctgc cctcaatcta gaacgctaca caagaaatat ttgttttact cagcaggtgt   1920

gccttaacct ccctattcag aaagctccac atcaataaac atgacactct gaagtgaaag   1980

tagccacgag aattgtgcta cttatactgg ttcataatct ggaggcaagg ttcgactgca   2040

gccgccccgt cagcctgtgc taggcatggt gtcttcacag gaggcaaatc cagagcctgg   2100

ctgtggggaa agtgaccact ctgccctgac cccgatcagt taaggagctg tgcaataacc   2160

ttcctagtac ctgagtgagt gtgtaactta ttgggttggc gaagcctggt aaagctgttg   2220

gaatgagtat gtgattcttt ttaagtatga aaataaagat atatgtacag acttgtattt   2280

tttctctggt ggcattcctt taggaatgct gtgtgtctgt ccggcacccc ggtaggcctg   2340

attgggtttc tagtcctcct taaccactta tctcccatat gagagtgtga aaaataggaa   2400

cacgtgctct acctccattt agggatttgc ttgggataca gaagaggcca tgtgtctcag   2460

agctgttaag ggcttatttt tttaaaacat tggagtcata gcatgtgtgt aaactttaaa   2520

tatgcaaata aataagtatc tatgtctaaa aaaa                               2554


<210>  2
<211>  8680
<212>  DNA
<213>  Homo sapiens

<400>  2
acggggcctg aagcggcggt accggtgctg gcggcggcag ctgaggcctt ggccgaagcc     60

gcgcgaacct cagggcaaga tgcttggaac cggacctgcc gccgccacca ccgctgccac    120

cacatctagc aatgtgagcg tcctgcagca gtttgccagt ggcctaaaga gccggaatga    180

ggaaaccagg gccaaagccg ccaaggagct ccagcactat gtcaccatgg aactccgaga    240

gatgagtcaa gaggagtcta ctcgcttcta tgaccaactg aaccatcaca tttttgaatt    300

ggtttccagc tcagatgcca atgagaggaa aggtggcatc ttggccatag ctagcctcat    360

aggagtggaa ggtgggaatg ccacccgaat tggcagattt gccaactatc ttcggaacct    420

cctcccctcc aatgacccag ttgtcatgga aatggcatcc aaggccattg gccgtcttgc    480

catggcaggg gacactttta ccgctgagta cgtggaattt gaggtgaagc gagccctgga    540

atggctgggt gctgaccgca atgagggccg gagacatgca gctgtcctgg ttctccgtga    600

gctggccatc agcgtcccta ccttcttctt ccagcaagtg caacccttct ttgacaacat    660

ttttgtggcc gtgtgggacc ccaaacaggc catccgtgag ggagctgtag ccgcccttcg    720

tgcctgtctg attctcacaa cccagcgtga gccgaaggag atgcagaagc ctcagtggta    780

caggcacaca tttgaagaag cagagaaggg atttgatgag accttggcca aagagaaggg    840

catgaatcgg gatgatcgga tccatggagc cttgttgatc cttaacgagc tggtccgaat    900

cagcagcatg gagggagagc gtctgagaga agaaatggaa gaaatcacac agcagcagct    960

ggtacacgac aagtactgca aagatctcat gggcttcgga acaaaacctc gtcacattac   1020

ccccttcacc agtttccagg ctgtacagcc ccagcagtca aatgccttgg tggggctgct   1080

ggggtacagc tctcaccaag gcctcatggg atttgggacc tcccccagtc cagctaagtc   1140

caccctggtg gagagccggt gttgcagaga cttgatggag gagaaatttg atcaggtgtg   1200

ccagtgggtg ctgaaatgca ggaatagcaa gaactcgctg atccaaatga caatccttaa   1260

tttgttgccc cgcttggctg cattccgacc ttctgccttc acagataccc agtatctcca   1320

agataccatg aaccatgtcc taagctgtgt caagaaggag aaggaacgta cagcggcctt   1380

ccaagccctg gggctacttt ctgtggctgt gaggtctgag tttaaggtct atttgcctcg   1440

cgtgctggac atcatccgag cggccctgcc cccaaaggac ttcgcccata agaggcagaa   1500

ggcaatgcag gtggatgcca cagtcttcac ttgcatcagc atgctggctc gagcaatggg   1560

gccaggcatc cagcaggata tcaaggagct gctggagccc atgctggcag tgggactaag   1620

ccctgccctc actgcagtgc tctacgacct gagccgtcag attccacagc taaagaagga   1680

cattcaagat gggctactga aaatgctgtc cctggtcctt atgcacaaac cccttcgcca   1740

cccaggcatg cccaagggcc tggcccatca gctggcctct cctggcctca cgaccctccc   1800

tgaggccagc gatgtgggca gcatcactct tgccctccga acgcttggca gctttgaatt   1860

tgaaggccac tctctgaccc aatttgttcg ccactgtgcg gatcatttcc tgaacagtga   1920

gcacaaggag atccgcatgg aggctgcccg cacctgctcc cgcctgctca caccctccat   1980

ccacctcatc agtggccatg ctcatgtggt tagccagacc gcagtgcaag tggtggcaga   2040

tgtgcttagc aaactgctcg tagttgggat aacagatcct gaccctgaca ttcgctactg   2100

tgtcttggcg tccctggacg agcgctttga tgcacacctg gcccaggcgg agaacttgca   2160

ggccttgttt gtggctctga atgaccaggt gtttgagatc cgggagctgg ccatctgcac   2220

tgtgggccga ctcagtagca tgaaccctgc ctttgtcatg cctttcctgc gcaagatgct   2280

catccagatt ttgacagagt tggagcacag tgggattgga agaatcaaag agcagagtgc   2340

ccgcatgctg gggcacctgg tctccaatgc cccccgactc atccgcccct acatggagcc   2400

tattctgaag gcattaattt tgaaactgaa agatccagac cctgatccaa acccaggtgt   2460

gatcaataat gtcctggcaa caataggaga attggcacag gttagtggcc tggaaatgag   2520

gaaatgggtt gatgaacttt ttattatcat catggacatg ctccaggatt cctctttgtt   2580

ggccaaaagg caggtggctc tgtggaccct gggacagttg gtggccagca ctggctatgt   2640

agtagagccc tacaggaagt accctacttt gcttgaggtg ctactgaatt ttctgaagac   2700

tgagcagaac cagggtacac gcagagaggc catccgtgtg ttagggcttt taggggcttt   2760

ggatccttac aagcacaaag tgaacattgg catgatagac cagtcccggg atgcctctgc   2820

tgtcagcctg tcagaatcca agtcaagtca ggattcctct gactatagca ctagtgaaat   2880

gctggtcaac atgggaaact tgcctctgga tgagttctac ccagctgtgt ccatggtggc   2940

cctgatgcgg atcttccgag accagtcact ctctcatcat cacaccatgg ttgtccaggc   3000

catcaccttc atcttcaagt ccctgggact caaatgtgtg cagttcctgc cccaggtcat   3060

gcccacgttc cttaacgtca ttcgagtctg tgatggggcc atccgggaat ttttgttcca   3120

gcagctggga atgttggtgt cctttgtgaa gagccacatc agaccttata tggatgaaat   3180

agtcaccctc atgagagaat tctgggtcat gaacacctca attcagagca cgatcattct   3240

tctcattgag caaattgtgg tagctcttgg gggtgaattt aagctctacc tgccccagct   3300

gatcccacac atgctgcgtg tcttcatgca tgacaacagc ccaggccgca ttgtctctat   3360

caagttactg gctgcaatcc agctgtttgg cgccaacctg gatgactacc tgcatttact   3420

gctgcctcct attgttaagt tgtttgatgc ccctgaagct ccactgccat ctcgaaaggc   3480

agcgctagag actgtggacc gcctgacgga gtccctggat ttcactgact atgcctcccg   3540

gatcattcac cctattgttc gaacactgga ccagagccca gaactgcgct ccacagccat   3600

ggacacgctg tcttcacttg tttttcagct ggggaagaag taccaaattt tcattccaat   3660

ggtgaataaa gttctggtgc gacaccgaat caatcatcag cgctatgatg tgctcatctg   3720

cagaattgtc aagggataca cacttgctga tgaagaggag gatcctttga tttaccagca   3780

tcggatgctt aggagtggcc aaggggatgc attggctagt ggaccagtgg aaacaggacc   3840

catgaagaaa ctgcacgtca gcaccatcaa cctccaaaag gcctggggcg ctgccaggag   3900

ggtctccaaa gatgactggc tggaatggct gagacggctg agcctggagc tgctgaagga   3960

ctcatcatcg ccctccctgc gctcctgctg ggccctggca caggcctaca acccgatggc   4020

cagggatctc ttcaatgctg catttgtgtc ctgctggtct gaactgaatg aagatcaaca   4080

ggatgagctc atcagaagca tcgagttggc cctcacctca caagacatcg ctgaagtcac   4140

acagaccctc ttaaacttgg ctgaattcat ggaacacagt gacaagggcc ccctgccact   4200

gagagatgac aatggcattg ttctgctggg tgagagagct gccaagtgcc gagcatatgc   4260

caaagcacta cactacaaag aactggagtt ccagaaaggc cccacccctg ccattctaga   4320

atctctcatc agcattaata ataagctaca gcagccggag gcagcggccg gagtgttaga   4380

atatgccatg aaacactttg gagagctgga gatccaggct acctggtatg agaaactgca   4440

cgagtgggag gatgcccttg tggcctatga caagaaaatg gacaccaaca aggacgaccc   4500

agagctgatg ctgggccgca tgcgctgcct cgaggccttg ggggaatggg gtcaactcca   4560

ccagcagtgc tgtgaaaagt ggaccctggt taatgatgag acccaagcca agatggcccg   4620

gatggctgct gcagctgcat ggggtttagg tcagtgggac agcatggaag aatacacctg   4680

tatgatccct cgggacaccc atgatggggc attttataga gctgtgctgg cactgcatca   4740

ggacctcttc tccttggcac aacagtgcat tgacaaggcc agggacctgc tggatgctga   4800

attaactgcg atggcaggag agagttacag tcgggcatat ggggccatgg tttcttgcca   4860

catgctgtcc gagctggagg aggttatcca gtacaaactt gtccccgagc gacgagagat   4920

catccgccag atctggtggg agagactgca gggctgccag cgtatcgtag aggactggca   4980

gaaaatcctt atggtgcggt cccttgtggt cagccctcat gaagacatga gaacctggct   5040

caagtatgca agcctgtgcg gcaagagtgg caggctggct cttgctcata aaactttagt   5100

gttgctcctg ggagttgatc cgtctcggca acttgaccat cctctgccaa cagttcaccc   5160

tcaggtgacc tatgcctaca tgaaaaacat gtggaagagt gcccgcaaga tcgatgcctt   5220

ccagcacatg cagcattttg tccagaccat gcagcaacag gcccagcatg ccatcgctac   5280

tgaggaccag cagcataagc aggaactgca caagctcatg gcccgatgct tcctgaaact   5340

tggagagtgg cagctgaatc tacagggcat caatgagagc acaatcccca aagtgctgca   5400

gtactacagc gccgccacag agcacgaccg cagctggtac aaggcctggc atgcgtgggc   5460

agtgatgaac ttcgaagctg tgctacacta caaacatcag aaccaagccc gcgatgagaa   5520

gaagaaactg cgtcatgcca gcggggccaa catcaccaac gccaccactg ccgccaccac   5580

ggccgccact gccaccacca ctgccagcac cgagggcagc aacagtgaga gcgaggccga   5640

gagcaccgag aacagcccca ccccatcgcc gctgcagaag aaggtcactg aggatctgtc   5700

caaaaccctc ctgatgtaca cggtgcctgc cgtccagggc ttcttccgtt ccatctcctt   5760

gtcacgaggc aacaacctcc aggatacact cagagttctc accttatggt ttgattatgg   5820

tcactggcca gatgtcaatg aggccttagt ggagggggtg aaagccatcc agattgatac   5880

ctggctacag gttatacctc agctcattgc aagaattgat acgcccagac ccttggtggg   5940

acgtctcatt caccagcttc tcacagacat tggtcggtac cacccccagg ccctcatcta   6000

cccactgaca gtggcttcta agtctaccac gacagcccgg cacaatgcag ccaacaagat   6060

tctgaagaac atgtgtgagc acagcaacac cctggtccag caggccatga tggtgagcga   6120

ggagctgatc cgagtggcca tcctctggca tgagatgtgg catgaaggcc tggaagaggc   6180

atctcgtttg tactttgggg aaaggaacgt gaaaggcatg tttgaggtgc tggagccctt   6240

gcatgctatg atggaacggg gcccccagac tctgaaggaa acatccttta atcaggccta   6300

tggtcgagat ttaatggagg cccaagagtg gtgcaggaag tacatgaaat cagggaatgt   6360

caaggacctc acccaagcct gggacctcta ttatcatgtg ttccgacgaa tctcaaagca   6420

gctgcctcag ctcacatcct tagagctgca atatgtttcc ccaaaacttc tgatgtgccg   6480

ggaccttgaa ttggctgtgc caggaacata tgaccccaac cagccaatca ttcgcattca   6540

gtccatagca ccgtctttgc aagtcatcac atccaagcag aggccccgga aattgacact   6600

tatgggcagc aacggacatg agtttgtttt ccttctaaaa ggccatgaag atctgcgcca   6660

ggatgagcgt gtgatgcagc tcttcggcct ggttaacacc cttctggcca atgacccaac   6720

atctcttcgg aaaaacctca gcatccagag atacgctgtc atccctttat cgaccaactc   6780

gggcctcatt ggctgggttc cccactgtga cacactgcac gccctcatcc gggactacag   6840

ggagaagaag aagatccttc tcaacatcga gcatcgcatc atgttgcgga tggctccgga   6900

ctatgaccac ttgactctga tgcagaaggt ggaggtgttt gagcatgccg tcaataatac   6960

agctggggac gacctggcca agctgctgtg gctgaaaagc cccagctccg aggtgtggtt   7020

tgaccgaaga accaattata cccgttcttt agcggtcatg tcaatggttg ggtatatttt   7080

aggcctggga gatagacacc catccaacct gatgctggac cgtctgagtg ggaagatcct   7140

gcacattgac tttggggact gctttgaggt tgctatgacc cgagagaagt ttccagagaa   7200

gattccattt agactaacaa gaatgttgac caatgctatg gaggttacag gcctggatgg   7260

caactacaga atcacatgcc acacagtgat ggaggtgctg cgagagcaca aggacagtgt   7320

catggccgtg ctggaagcct ttgtctatga ccccttgctg aactggaggc tgatggacac   7380

aaataccaaa ggcaacaagc gatcccgaac gaggacggat tcctactctg ctggccagtc   7440

agtcgaaatt ttggacggtg tggaacttgg agagccagcc cataagaaaa cggggaccac   7500

agtgccagaa tctattcatt ctttcattgg agacggtttg gtgaaaccag aggccctaaa   7560

taagaaagct atccagatta ttaacagggt tcgagataag ctcactggtc gggacttctc   7620

tcatgatgac actttggatg ttccaacgca agttgagctg ctcatcaaac aagcgacatc   7680

ccatgaaaac ctctgccagt gctatattgg ctggtgccct ttctggtaac tggaggccca   7740

gatgtgccca tcacgttttt tctgaggctt ttgtacttta gtaaatgctt ccactaaact   7800

gaaaccatgg tgagaaagtt tgactttgtt aaatattttg aaatgtaaat gaaaagaact   7860

actgtatatt aaaagttggt ttgaaccaac tttctagctg ctgttgaaga atatattgtc   7920

agaaacacaa ggcttgattt ggttcccagg acagtgaaac aatagtaata ccacgtaaat   7980

caagccattc attttgggga acagaagatc cataacttta gaaatacggg ttttgactta   8040

actcacaaga gaactcatca taagtacttg ctgatggaag aatgacctag ttgctcctct   8100

caacatgggt acagcaaact cagcacagcc aagaagcctc aggtcgtgga gaacatggat   8160

taggatccta gactgtaaag acacagaaga tgctgacctc acccctgcca cctatcccaa   8220

gacctcactg gtctgtggac agcagcagaa atgtttgcaa gataggccaa aatgagtaca   8280

aaaggtctgt cttccatcag acccagtgat gctgcgactc acacgcttca attcaagacc   8340

tgaccgctag tagggaggtt tattcagatc gctggcagcc tcggctgagc agatgcacag   8400

aggggatcac tgtgcagtgg gaccaccctc actggccttc tgcagcaggg ttctgggatg   8460

ttttcagtgg tcaaaatact ctgtttagag caagggctca gaaaacagaa atactgtcat   8520

ggaggtgctg aacacaggga aggtctggta catattggaa attatgagca gaacaaatac   8580

tcaactaaat gcacaaagta taaagtgtag ccatgtctag acaccatgtt gtatcagaat   8640

aatttttgtg ccaataaatg acatcagaat tttaaacata                         8680


<210>  3
<211>  5916
<212>  DNA
<213>  Homo sapiens

<400>  3
gcccctccct ccgcccgccc gccggcccgc ccgtcagtct ggcaggcagg caggcaatcg     60

gtccgagtgg ctgtcggctc ttcagctctc ccgctcggcg tcttccttcc tcctcccggt    120

cagcgtcggc ggctgcaccg gcggcggcgc agtccctgcg ggaggggcga caagagctga    180

gcggcggccg ccgagcgtcg agctcagcgc ggcggaggcg gcggcggccc ggcagccaac    240

atggcggcgg cggcggcggc gggcgcgggc ccggagatgg tccgcgggca ggtgttcgac    300

gtggggccgc gctacaccaa cctctcgtac atcggcgagg gcgcctacgg catggtgtgc    360

tctgcttatg ataatgtcaa caaagttcga gtagctatca agaaaatcag cccctttgag    420

caccagacct actgccagag aaccctgagg gagataaaaa tcttactgcg cttcagacat    480

gagaacatca ttggaatcaa tgacattatt cgagcaccaa ccatcgagca aatgaaagat    540

gtatatatag tacaggacct catggaaaca gatctttaca agctcttgaa gacacaacac    600

ctcagcaatg accatatctg ctattttctc taccagatcc tcagagggtt aaaatatatc    660

cattcagcta acgttctgca ccgtgacctc aagccttcca acctgctgct caacaccacc    720

tgtgatctca agatctgtga ctttggcctg gcccgtgttg cagatccaga ccatgatcac    780

acagggttcc tgacagaata tgtggccaca cgttggtaca gggctccaga aattatgttg    840

aattccaagg gctacaccaa gtccattgat atttggtctg taggctgcat tctggcagaa    900

atgctttcta acaggcccat ctttccaggg aagcattatc ttgaccagct gaaccacatt    960

ttgggtattc ttggatcccc atcacaagaa gacctgaatt gtataataaa tttaaaagct   1020

aggaactatt tgctttctct tccacacaaa aataaggtgc catggaacag gctgttccca   1080

aatgctgact ccaaagctct ggacttattg gacaaaatgt tgacattcaa cccacacaag   1140

aggattgaag tagaacaggc tctggcccac ccatatctgg agcagtatta cgacccgagt   1200

gacgagccca tcgccgaagc accattcaag ttcgacatgg aattggatga cttgcctaag   1260

gaaaagctca aagaactaat ttttgaagag actgctagat tccagccagg atacagatct   1320

taaatttgtc aggacaaggg ctcagaggac tggacgtgct cagacatcgg tgttcttctt   1380

cccagttctt gacccctggt cctgtctcca gcccgtcttg gcttatccac tttgactcct   1440

ttgagccgtt tggaggggcg gtttctggta gttgtggctt ttatgctttc aaagaatttc   1500

ttcagtccag agaattcctc ctggcagccc tgtgtgtgtc acccattggt gacctgcggc   1560

agtatgtact tcagtgcacc tactgcttac tgttgcttta gtcactaatt gctttctggt   1620

ttgaaagatg cagtggttcc tccctctcct gaatcctttt ctacatgatg ccctgctgac   1680

catgcagccg caccagagag agattcttcc ccaattggct ctagtcactg gcatctcact   1740

ttatgatagg gaaggctact acctagggca ctttaagtca gtgacagccc cttatttgca   1800

cttcaccttt tgaccataac tgtttcccca gagcaggagc ttgtggaaat accttggctg   1860

atgttgcagc ctgcagcaag tgcttccgtc tccggaatcc ttggggagca cttgtccacg   1920

tcttttctca tatcatggta gtcactaaca tatataaggt atgtgctatt ggcccagctt   1980

ttagaaaatg cagtcatttt tctaaataaa aaggaagtac tgcacccagc agtgtcactc   2040

tgtagttact gtggtcactt gtaccatata gaggtgtaac acttgtcaag aagcgttatg   2100

tgcagtactt aatgtttgta agacttacaa aaaaagattt aaagtggcag cttcactcga   2160

catttggtga gagaagtaca aaggttgcag tgctgagctg tgggcggttt ctggggatgt   2220

cccagggtgg aactccacat gctggtgcat atacgccctt gagctacttc aaatgtgggt   2280

gtttcagtaa ccacgttcca tgcctgagga tttagcagag aggaacactg cgtctttaaa   2340

tgagaaagta tacaattctt tttccttcta cagcatgtca gcatctcaag ttcatttttc   2400

aacctacagt ataacaattt gtaataaagc ctccaggagc tcatgacgtg aagcactgtt   2460

ctgtcctcaa gtactcaaat atttctgata ctgctgagtc agactgtcag aaaaagctag   2520

cactaactcg tgtttggagc tctatccata ttttactgat ctctttaagt atttgttcct   2580

gccactgtgt actgtggagt tgactcggtg ttctgtccca gtgcggtgcc tcctcttgac   2640

ttccccactg ctctctgtgg tgagaaattt gccttgttca ataattactg taccctcgca   2700

tgactgttac agctttctgt gcagagatga ctgtccaagt gccacatgcc tacgattgaa   2760

atgaaaactc tattgttacc tctgagttgt gttccacgga aaatgctatc cagcagatca   2820

tttaggaaaa ataattctat ttttagcttt tcatttctca gctgtccttt tttcttgttt   2880

gatttttgac agcaatggag aatgggttat ataaagactg cctgctaata tgaacagaaa   2940

tgcatttgta attcatgaaa ataaatgtac atcttctatc ttcacattca tgttaagatt   3000

cagtgttgct ttcctctgga tcagcgtgtc tgaatggaca gtcaggttca ggttgtgctg   3060

aacacagaaa tgctcacagg cctcactttg ccgcccaggc actggcccag cacttggatt   3120

tacataagat gagttagaaa ggtacttctg tagggtcctt tttacctctg ctcggcagag   3180

aatcgatgct gtcatgttcc tttattcaca atcttaggtc tcaaatattc tgtcaaaccc   3240

taacaaagaa gccccgacat ctcaggttgg attccctggt tctctctaaa gagggcctgc   3300

ccttgtgccc cagaggtgct gctgggcaca gccaagagtt gggaagggcc gccccacagt   3360

acgcagtcct caccacccag cccagggtgc tcacgctcac cactcctgtg gctgaggaag   3420

gatagctggc tcatcctcgg aaaacagacc cacatctcta ttcttgccct gaaatacgcg   3480

cttttcactt gcgtgctcag agctgccgtc tgaaggtcca cacagcattg acgggacaca   3540

gaaatgtgac tgttaccgga taacactgat tagtcagttt tcatttataa aaaagcattg   3600

acagttttat tactcttgtt tctttttaaa tggaaagtta ctattataag gttaatttgg   3660

agtcctcttc taaatagaaa accatatcct tggctactaa catctggaga ctgtgagctc   3720

cttcccattc cccttcctgg tactgtggag tcagattggc atgaaaccac taacttcatt   3780

ctagaatcat tgtagccata agttgtgtgc tttttattaa tcatgccaaa cataatgtaa   3840

ctgggcagag aatggtccta accaaggtac ctatgaaaag cgctagctat catgtgtagt   3900

agatgcatca ttttggctct tcttacattt gtaaaaatgt acagattagg tcatcttaat   3960

tcatattagt gacacggaac agcacctcca ctatttgtat gttcaaataa gctttcagac   4020

taatagcttt tttggtgtct aaaatgtaag caaaaaattc ctgctgaaac attccagtcc   4080

tttcatttag tataaaagaa atactgaaca agccagtggg atggaattga aagaactaat   4140

catgaggact ctgtcctgac acaggtcctc aaagctagca gagatacgca gacattgtgg   4200

catctgggta gaagaatact gtattgtgtg tgcagtgcac agtgtgtggt gtgtgcacac   4260

tcattccttc tgctcttggg cacaggcagt gggtgtagag gtaaccagta gctttgagaa   4320

gctacatgta gctcaccagt ggttttctct aaggaatcac aaaagtaaac tacccaacca   4380

catgccacgt aatatttcag ccattcagag gaaactgttt tctctttatt tgcttatatg   4440

ttaatatggt ttttaaattg gtaactttta tatagtatgg taacagtatg ttaatacaca   4500

catacatacg cacacatgct ttgggtcctt ccataatact tttatatttg taaatcaatg   4560

ttttggagca atcccaagtt taagggaaat atttttgtaa atgtaatggt tttgaaaatc   4620

tgagcaatcc ttttgcttat acatttttaa agcatttgtg ctttaaaatt gttatgctgg   4680

tgtttgaaac atgatactcc tgtggtgcag atgagaagct ataacagtga atatgtggtt   4740

tctcttacgt catccacctt gacatgatgg gtcagaaaca aatggaaatc cagagcaagt   4800

cctccagggt tgcaccaggt ttacctaaag cttgttgcct tttcttgtgc tgtttatgcg   4860

tgtagagcac tcaagaaagt tctgaaactg ctttgtatct gctttgtact gttggtgcct   4920

tcttggtatt gtaccccaaa attctgcata gattatttag tataatggta agttaaaaaa   4980

tgttaaagga agattttatt aagaatctga atgtttattc attatattgt tacaatttaa   5040

cattaacatt tatttgtggt atttgtgatt tggttaatct gtataaaaat tgtaagtaga   5100

aaggtttata tttcatctta attcttttga tgttgtaaac gtacttttta aaagatggat   5160

tatttgaatg tttatggcac ctgacttgta aaaaaaaaaa actacaaaaa aatccttaga   5220

atcattaaat tgtgtccctg tattaccaaa ataacacagc accgtgcatg tatagtttaa   5280

ttgcagtttc atctgtgaaa acgtgaaatt gtctagtcct tcgttatgtt ccccagatgt   5340

cttccagatt tgctctgcat gtggtaactt gtgttagggc tgtgagctgt tcctcgagtt   5400

gaatggggat gtcagtgctc ctagggttct ccaggtggtt cttcagacct tcacctgtgg   5460

gggggggggt aggcggtgcc cacgcccatc tcctcatcct cctgaacttc tgcaacccca   5520

ctgctgggca gacatcctgg gcaacccctt ttttcagagc aagaagtcat aaagatagga   5580

tttcttggac atttggttct tatcaatatt gggcattatg taatgactta tttacaaaac   5640

aaagatactg gaaaatgttt tggatgtggt gttatggaaa gagcacaggc cttggaccca   5700

tccagctggg ttcagaacta ccccctgctt ataactgcgg ctggctgtgg gccagtcatt   5760

ctgcgtctct gctttcttcc tctgcttcag actgtcagct gtaaagtgga agcaatatta   5820

cttgccttgt atatggtaaa gattataaaa atacatttca actgttcagc atagtacttc   5880

aaagcaagta ctcagtaaat agcaagtctt tttaaa                             5916


<210>  4
<211>  2603
<212>  DNA
<213>  Homo sapiens

<400>  4
aggcgaggct tccccttccc cgcccctccc ccggcctcca gtccctccca gggccgcttc     60

gcagagcggc taggagcacg gcggcggcgg cactttcccc ggcaggagct ggagctgggc    120

tctggtgcgc gcgcggctgt gccgcccgag ccggagggac tggttggttg agagagagag    180

aggaagggaa tcccgggctg ccgaaccgca cgttcagccc gctccgctcc tgcagggcag    240

cctttcggct ctctgcgcgc gaagccgagt cccgggcggg tggggcgggg gtccactgag    300

accgctaccg gcccctcggc gctgacggga ccgcgcgggg cgcacccgct gaaggcagcc    360

ccggggcccg cggcccggac ttggtcctgc gcagcgggcg cggggcagcg cagcgggagg    420

aagcgagagg tgctgccctc cccccggagt tggaagcgcg ttacccgggt ccaaaatgcc    480

caagaagaag ccgacgccca tccagctgaa cccggccccc gacggctctg cagttaacgg    540

gaccagctct gcggagacca acttggaggc cttgcagaag aagctggagg agctagagct    600

tgatgagcag cagcgaaagc gccttgaggc ctttcttacc cagaagcaga aggtgggaga    660

actgaaggat gacgactttg agaagatcag tgagctgggg gctggcaatg gcggtgtggt    720

gttcaaggtc tcccacaagc cttctggcct ggtcatggcc agaaagctaa ttcatctgga    780

gatcaaaccc gcaatccgga accagatcat aagggagctg caggttctgc atgagtgcaa    840

ctctccgtac atcgtgggct tctatggtgc gttctacagc gatggcgaga tcagtatctg    900

catggagcac atggatggag gttctctgga tcaagtcctg aagaaagctg gaagaattcc    960

tgaacaaatt ttaggaaaag ttagcattgc tgtaataaaa ggcctgacat atctgaggga   1020

gaagcacaag atcatgcaca gagatgtcaa gccctccaac atcctagtca actcccgtgg   1080

ggagatcaag ctctgtgact ttggggtcag cgggcagctc atcgactcca tggccaactc   1140

cttcgtgggc acaaggtcct acatgtcgcc agaaagactc caggggactc attactctgt   1200

gcagtcagac atctggagca tgggactgtc tctggtagag atggcggttg ggaggtatcc   1260

catccctcct ccagatgcca aggagctgga gctgatgttt gggtgccagg tggaaggaga   1320

tgcggctgag accccaccca ggccaaggac ccccgggagg ccccttagct catacggaat   1380

ggacagccga cctcccatgg caatttttga gttgttggat tacatagtca acgagcctcc   1440

tccaaaactg cccagtggag tgttcagtct ggaatttcaa gattttgtga ataaatgctt   1500

aataaaaaac cccgcagaga gagcagattt gaagcaactc atggttcatg cttttatcaa   1560

gagatctgat gctgaggaag tggattttgc aggttggctc tgctccacca tcggccttaa   1620

ccagcccagc acaccaaccc atgctgctgg cgtctaagtg tttgggaagc aacaaagagc   1680

gagtcccctg cccggtggtt tgccatgtcg cttttgggcc tccttcccat gcctgtctct   1740

gttcagatgt gcatttcacc tgtgacaaag gatgaagaac acagcatgtg ccaagattct   1800

actcttgtca tttttaatat tactgtcttt attcttatta ctattattgt tcccctaagt   1860

ggattggctt tgtgcttggg gctatttgtg tgtatgctga tgatcaaaac ctgtgccagg   1920

ctgaattaca gtgaaatttt ggtgaatgtg ggtagtcatt cttacaattg cactgctgtt   1980

cctgctccat gactggctgt ctgcctgtat tttcgggatt ctttgacatt tggtggtact   2040

ttattcttgc tgggcatact ttctctctag gagggagcct tgtgagatcc ttcacaggca   2100

gtgcatgtga agcatgcttt gctgctatga aaatgagcat cagagagtgt acatcatgtt   2160

attttattat tattatttgc ttttcatgta gaactcagca gttgacatcc aaatctagcc   2220

agagcccttc actgccatga tagctggggc ttcaccagtc tgtctactgt ggtgatctgt   2280

agacttctgg ttgtatttct atatttattt tcagtatact gtgtgggata cttagtggta   2340

tgtctcttta agttttgatt aatgtttctt aaatggaatt attttgaatg tcacaaattg   2400

atcaagatat taaaatgtcg gatttatctt tccccatatc caagtaccaa tgctgttgta   2460

aacaacgtgt atagtgccta aaattgtatg aaaatccttt taaccatttt aacctagatg   2520

tttaacaaat ctaatctctt attctaataa atatactatg aaataaaaaa aaaaggatga   2580

aagctaaaaa aaaaaaaaaa aaa                                           2603


<210>  5
<211>  829
<212>  DNA
<213>  Homo sapiens

<400>  5
cctcttttcc gtggcgcctc ggaggcgttc agctgcttca agatgaagct gaacatctcc     60

ttcccagcca ctggctgcca gaaactcatt gaagtggacg atgaacgcaa acttcgtact    120

ttctatgaga agcgtatggc cacagaagtt gctgctgacg ctctgggtga agaatggaag    180

ggttatgtgg tccgaatcag tggtgggaac gacaaacaag gtttccccat gaagcagggt    240

gtcttgaccc atggccgtgt ccgcctgcta ctgagtaagg ggcattcctg ttacagacca    300

aggagaactg gagaaagaaa gagaaaatca gttcgtggtt gcattgtgga tgcaaatctg    360

agcgttctca acttggttat tgtaaaaaaa ggagagaagg atattcctgg actgactgat    420

actacagtgc ctcgccgcct gggccccaaa agagctagca gaatccgcaa acttttcaat    480

ctctctaaag aagatgatgt ccgccagtat gttgtaagaa agcccttaaa taaagaaggt    540

aagaaaccta ggaccaaagc acccaagatt cagcgtcttg ttactccacg tgtcctgcag    600

cacaaacggc ggcgtattgc tctgaagaag cagcgtacca agaaaaataa agaagaggct    660

gcagaatatg ctaaactttt ggccaagaga atgaaggagg ctaaggagaa gcgccaggaa    720

caaattgcga agagacgcag actttcctct ctgcgagctt ctacttctaa gtctgaatcc    780

agtcagaaat aagatttttt gagtaacaaa taaataagat cagactctg                829


<210>  6
<211>  3008
<212>  DNA
<213>  Homo sapiens

<400>  6
taattatggg tctgtaacca ccctggactg ggtgctcctc actgacggac ttgtctgaac     60

ctctctttgt ctccagcgcc cagcactggg cctggcaaaa cctgagacgc ccggtacatg    120

ttggccaaat gaatgaacca gattcagacc ggcaggggcg ctgtggttta ggaggggcct    180

ggggtttctc ccaggaggtt tttgggcttg cgctggaggg ctctggactc ccgtttgcgc    240

cagtggcctg catcctggtc ctgtcttcct catgtttgaa tttctttgct ttcctagtct    300

ggggagcagg gaggagccct gtgccctgtc ccaggatcca tgggtaggaa caccatggac    360

agggagagca aacggggcca tctgtcacca ggggcttagg gaaggccgag ccagcctggg    420

tcaaagaagt caaaggggct gcctggagga ggcagcctgt cagctggtgc atcagaggct    480

gtggccaggc cagctgggct cggggagcgc cagcctgaga ggagcgcgtg agcgtcgcgg    540

gagcctcggg caccatgagc gacgtggcta ttgtgaagga gggttggctg cacaaacgag    600

gggagtacat caagacctgg cggccacgct acttcctcct caagaatgat ggcaccttca    660

ttggctacaa ggagcggccg caggatgtgg accaacgtga ggctcccctc aacaacttct    720

ctgtggcgca gtgccagctg atgaagacgg agcggccccg gcccaacacc ttcatcatcc    780

gctgcctgca gtggaccact gtcatcgaac gcaccttcca tgtggagact cctgaggagc    840

gggaggagtg gacaaccgcc atccagactg tggctgacgg cctcaagaag caggaggagg    900

aggagatgga cttccggtcg ggctcaccca gtgacaactc aggggctgaa gagatggagg    960

tgtccctggc caagcccaag caccgcgtga ccatgaacga gtttgagtac ctgaagctgc   1020

tgggcaaggg cactttcggc aaggtgatcc tggtgaagga gaaggccaca ggccgctact   1080

acgccatgaa gatcctcaag aaggaagtca tcgtggccaa ggacgaggtg gcccacacac   1140

tcaccgagaa ccgcgtcctg cagaactcca ggcacccctt cctcacagcc ctgaagtact   1200

ctttccagac ccacgaccgc ctctgctttg tcatggagta cgccaacggg ggcgagctgt   1260

tcttccacct gtcccgggag cgtgtgttct ccgaggaccg ggcccgcttc tatggcgctg   1320

agattgtgtc agccctggac tacctgcact cggagaagaa cgtggtgtac cgggacctca   1380

agctggagaa cctcatgctg gacaaggacg ggcacattaa gatcacagac ttcgggctgt   1440

gcaaggaggg gatcaaggac ggtgccacca tgaagacctt ttgcggcaca cctgagtacc   1500

tggcccccga ggtgctggag gacaatgact acggccgtgc agtggactgg tgggggctgg   1560

gcgtggtcat gtacgagatg atgtgcggtc gcctgccctt ctacaaccag gaccatgaga   1620

agctttttga gctcatcctc atggaggaga tccgcttccc gcgcacgctt ggtcccgagg   1680

ccaagtcctt gctttcaggg ctgctcaaga aggaccccaa gcagaggctt ggcgggggct   1740

ccgaggacgc caaggagatc atgcagcatc gcttctttgc cggtatcgtg tggcagcacg   1800

tgtacgagaa gaagctcagc ccacccttca agccccaggt cacgtcggag actgacacca   1860

ggtattttga tgaggagttc acggcccaga tgatcaccat cacaccacct gaccaagatg   1920

acagcatgga gtgtgtggac agcgagcgca ggccccactt cccccagttc tcctactcgg   1980

ccagcggcac ggcctgaggc ggcggtggac tgcgctggac gatagcttgg agggatggag   2040

aggcggcctc gtgccatgat ctgtatttaa tggtttttat ttctcgggtg catttgagag   2100

aagccacgct gtcctctcga gcccagatgg aaagacgttt ttgtgctgtg ggcagcaccc   2160

tcccccgcag cggggtaggg aagaaaacta tcctgcgggt tttaatttat ttcatccagt   2220

ttgttctccg ggtgtggcct cagccctcag aacaatccga ttcacgtagg gaaatgttaa   2280

ggacttctgc agctatgcgc aatgtggcat tggggggccg ggcaggtcct gcccatgtgt   2340

cccctcactc tgtcagccag ccgccctggg ctgtctgtca ccagctatct gtcatctctc   2400

tggggccctg ggcctcagtt caacctggtg gcaccagatg caacctcact atggtatgct   2460

ggccagcacc ctctcctggg ggtggcaggc acacagcagc cccccagcac taaggccgtg   2520

tctctgagga cgtcatcgga ggctgggccc ctgggatggg accagggatg ggggatgggc   2580

cagggtttac ccagtgggac agaggagcaa ggtttaaatt tgttattgtg tattatgttg   2640

ttcaaatgca ttttgggggt ttttaatctt tgtgacagga aagccctccc ccttcccctt   2700

ctgtgtcaca gttcttggtg actgtcccac cgggagcctc cccctcagat gatctctcca   2760

cggtagcact tgaccttttc gacgcttaac ctttccgctg tcgccccagg ccctccctga   2820

ctccctgtgg gggtggccat ccctgggccc ctccacgcct cctggccaga cgctgccgct   2880

gccgctgcac cacggcgttt ttttacaaca ttcaacttta gtatttttac tattataata   2940

taatatggaa ccttccctcc aaattcttca ataaaagttg cttttcaaaa aaaaaaaaaa   3000

aaaaaaaa                                                            3008


<210>  7
<211>  4343
<212>  DNA
<213>  Homo sapiens

<400>  7
tggtcatcgc acggcggcag ctcctcacct ggatttagaa gagctggcgt ccccgcccgc     60

ccaagccttt aaactctcgt ctgccagaac ccgccaactc tccaggctta gggccagttt    120

ccgcgattct aagagtaatt gcgtgggcac ctgtgctggg gccaggcgca aagaagggag    180

ttggtctgcg cgaagatcgt caacctgcta acagaccgca catgcacttt gcaccgacca    240

tctacgtctc agtctggagg ttgcgcactt tggctgctga cgcgctggtg gtgcctatta    300

atcatttacc agtccagagc cgcgccagtt aatggctgtg ccgtgcggtg ctcccacatc    360

ctggcctctc ctctccacgg tcgcctgtgc ccgggcaccc cggagctgca aactgcagag    420

cccaggcaac cgctgggctg tgcgccccgc cggcgccggt aggagccgcg ctccccgcag    480

cggttgcgct ctacccggag gcgctgggcg gctgtgggct gcaggcaagc ggtcgggtgg    540

ggagggaggg cgcaggcggc gggtgcgcga ggagaaagcc ccagccctgg cagccccact    600

ggcccccctc agctgggatg ttccccaatg gcaccgcctc ctctccttcc tcctctccta    660

gccccagccc gggcagctgc ggcgaaggcg gcggcagcag gggccccggg gccggcgctg    720

cggacggcat ggaggagcca gggcgaaatg cgtcccagaa cgggaccttg agcgagggcc    780

agggcagcgc catcctgatc tctttcatct actccgtggt gtgcctggtg gggctgtgtg    840

ggaactctat ggtcatctac gtgatcctgc gctatgccaa gatgaagacg gccaccaaca    900

tctacatcct aaatctggcc attgctgatg agctgctcat gctcagcgtg cccttcctag    960

tcacctccac gttgttgcgc cactggccct tcggtgcgct gctctgccgc ctcgtgctca   1020

gcgtggacgc ggtcaacatg ttcaccagca tctactgtct gactgtgctc agcgtggacc   1080

gctacgtggc cgtggtgcat cccatcaagg cggcccgcta ccgccggccc accgtggcca   1140

aggtagtaaa cctgggcgtg tgggtgctat cgctgctcgt catcctgccc atcgtggtct   1200

tctctcgcac cgcggccaac agcgacggca cggtggcttg caacatgctc atgccagagc   1260

ccgctcaacg ctggctggtg ggcttcgtgt tgtacacatt tctcatgggc ttcctgctgc   1320

ccgtgggggc tatctgcctg tgctacgtgc tcatcattgc taagatgcgc atggtggccc   1380

tcaaggccgg ctggcagcag cgcaagcgct cggagcgcaa gatcacctta atggtgatga   1440

tggtggtgat ggtgtttgtc atctgctgga tgcctttcta cgtggtgcag ctggtcaacg   1500

tgtttgctga gcaggacgac gccacggtga gtcagctgtc ggtcatcctc ggctatgcca   1560

acagctgcgc caaccccatc ctctatggct ttctctcaga caacttcaag cgctctttcc   1620

aacgcatcct atgcctcagc tggatggaca acgccgcgga ggagccggtt gactattacg   1680

ccaccgcgct caagagccgt gcctacagtg tggaagactt ccaacctgag aacctggagt   1740

ccggcggcgt cttccgtaat ggcacctgca cgtcccggat cacgacgctc tgagcccggg   1800

ccacgcaggg gctctgagcc cgggccacgc aggggccctg agccaaaaga gggggagaat   1860

gagaagggaa ggccgggtgc gaaagggacg gtatccaggg cgccagggtg ctgtcgggat   1920

aacgtggggc taggacactg acagcctttg atggaggaac ccaagaaagg cgcgcgacaa   1980

tggtagaagt gagagctttg cttataaact gggaaggctt tcaggctacc tttttctggg   2040

tctcccactt tctgttcctt cctccactgc gcttactcct ctgaccctcc ttctattttc   2100

cctaccctgc aacttctatc ctttcttccg caccgtcccg ccagtgcaga tcacgaactc   2160

attaacaact cattctgatc ctcagcccct ccagtcgtta tttctgtttg tttaagctga   2220

gccacggata ccgccacggg tttccctcgg cgttagtccc tagccgcgcg gggccgctgt   2280

ccaggttctg tctggtgccc ctactggagt cccgggaatg accgctctcc ctttgcgcag   2340

ccctacctta aggaaagttg gacttgagaa agatctaagc agctggtctt ttctcctact   2400

cttgggtgaa ggtgcatctt tccctgccct cccctgtccc cctctcgccg cccgcccgcc   2460

accaccactc tcactccacc cagagtagag ccaggtgctt agtaaaatag gtcccgcgct   2520

tcgaactcca ggctttctgg agttcccacc caagccctcc tttggagcaa agaaggagct   2580

gagaacaagc cgaatgagga gtttttataa gattgcgggg tcggagtgtg ggcgcgtaat   2640

aggaatcacc ctcctactgc gcgttttcaa agaccaagcg ctgggcgctc ccgggccgcg   2700

cgtctgcgtt aggcagggca gggtagtgca gggcacacct tccccggggt tcggggttcg   2760

gggttcggtt gcagggctgc agcccgcctt ggctttctcc ctcacccaag tttccggagg   2820

agccgaccta aaagtaacaa tagataaggt ttcctgctcc agtgtatctc aaaagaccgg   2880

gcgccagggg cgggggacct agggcgacgt cttcagagtc cgccagtgtt ggcggtgtcg   2940

ccgcaacctg caggctcccg agtggggcct gcctggtctc tagagggttg ctgcctttca   3000

agcggtgcct aagaagttat tttcttgttt aacatatata tttattaatt tatttgtcgt   3060

gttggaaaat gtgtctctgc tttccttttc tctgcttgcc tagccccagg tcttttcttt   3120

gggaccctgg gggcgggcat ggaagtggaa gtaggggcaa gctcttgccc cactccctgg   3180

ccatctcaac gcctctcctc aatgctgggc cctcttatct catcctttcc tctagctttt   3240

ctatttttga ttgtgttgag tgaagtttgg agatttttca tacttttctt actatagtct   3300

cttgtttgtc ttattaggat aatacataaa tgataatgtg ggttatcctc ctctccatgc   3360

acagtggaaa gtcctgaact cctggctttc caggagacat atatagggga acatcaccct   3420

atatataatt tgagtgtata tatatttata tatatgatgt ggacatatgt atacttatct   3480

tgctccattg tcatgagtcc atgagtctaa gtatagccac tgatggtgac aggtgtgagt   3540

ctggctggaa cactttcagt ttcaggagtg caagcagcac tcaaacctgg agctgaggaa   3600

tctaattcag acagagactt taatcactgc tgaagatgcc cctgctccct ctgggttcca   3660

gcagaggtga ttcttacata tgatccagtt aacatcatca ctttttttga ggacattgaa   3720

agtgaaataa tttgtgtctg tgtttaatat taccaactac attggaagcc tgagcagggc   3780

gaggaccaat aattttaatt atttatattt cctgtattgc tttagtatgc tggcttgtac   3840

atagtaggca ctaaatacat gtttgttggt tgattgttta agccagagtg tattacaaca   3900

atctggagat actaaatctg gggttctcag gttcactcat tgacatgata tacaatggtt   3960

aaaatcacta ttgaaaaata cgttttgtgt atatttgctt caacaacttt gtgctttcct   4020

gaaagcagta accaagagtt aagatatccc taatgttttg cttaaactaa tgaacaaata   4080

tgctttgggt cataaatcag aaagtttaga tctgtccctt aataaaaata tatattacta   4140

ctcctttgga aaatagattt ttaatggtta agaactgtga aatttacaaa tcaaaatctt   4200

aatcattatc cttctaagag gatacaaatt tagtgctctt aacttgttac cattgtaata   4260

ttaactaaat aaacagatgt attatgctgt taaaaaaaaa aaaaaaaaaa aaaaaaaaaa   4320

aaaaaaaaaa aaaaaaaaaa aaa                                           4343


<210>  8
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210>  9
<211>  2549
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr Ala Ala Thr Thr Ser 
1               5                   10                  15      


Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg 
            20                  25                  30          


Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val 
        35                  40                  45              


Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr 
    50                  55                  60                  


Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala 
65                  70                  75                  80  


Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val 
                85                  90                  95      


Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg 
            100                 105                 110         


Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met Glu Met Ala Ser Lys 
        115                 120                 125             


Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr 
    130                 135                 140                 


Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg 
145                 150                 155                 160 


Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala 
                165                 170                 175     


Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp 
            180                 185                 190         


Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly 
        195                 200                 205             


Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu 
    210                 215                 220                 


Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu 
225                 230                 235                 240 


Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn 
                245                 250                 255     


Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val 
            260                 265                 270         


Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu 
        275                 280                 285             


Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met 
    290                 295                 300                 


Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln 
305                 310                 315                 320 


Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val Gly Leu Leu Gly Tyr 
                325                 330                 335     


Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr Ser Pro Ser Pro Ala 
            340                 345                 350         


Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu 
        355                 360                 365             


Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Asn Ser Lys 
    370                 375                 380                 


Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala 
385                 390                 395                 400 


Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr 
                405                 410                 415     


Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala 
            420                 425                 430         


Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe 
        435                 440                 445             


Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro 
    450                 455                 460                 


Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala Met Gln Val Asp Ala 
465                 470                 475                 480 


Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly 
                485                 490                 495     


Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly 
            500                 505                 510         


Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile 
        515                 520                 525             


Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser 
    530                 535                 540                 


Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly 
545                 550                 555                 560 


Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala 
                565                 570                 575     


Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe 
            580                 585                 590         


Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp 
        595                 600                 605             


His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg 
    610                 615                 620                 


Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His 
625                 630                 635                 640 


Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu 
                645                 650                 655     


Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg 
            660                 665                 670         


Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala 
        675                 680                 685             


Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val 
    690                 695                 700                 


Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser 
705                 710                 715                 720 


Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln 
                725                 730                 735     


Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln 
            740                 745                 750         


Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile 
        755                 760                 765             


Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys 
    770                 775                 780                 


Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala 
785                 790                 795                 800 


Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp 
                805                 810                 815     


Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met Leu Gln Asp Ser Ser 
            820                 825                 830         


Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val 
        835                 840                 845             


Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu 
    850                 855                 860                 


Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr 
865                 870                 875                 880 


Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro 
                885                 890                 895     


Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala 
            900                 905                 910         


Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp 
        915                 920                 925             


Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp 
    930                 935                 940                 


Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg 
945                 950                 955                 960 


Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr 
                965                 970                 975     


Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln 
            980                 985                 990         


Val Met Pro Thr Phe Leu Asn Val  Ile Arg Val Cys Asp  Gly Ala Ile 
        995                 1000                 1005             


Arg Glu  Phe Leu Phe Gln Gln  Leu Gly Met Leu Val  Ser Phe Val 
    1010                 1015                 1020             


Lys Ser  His Ile Arg Pro Tyr  Met Asp Glu Ile Val  Thr Leu Met 
    1025                 1030                 1035             


Arg Glu  Phe Trp Val Met Asn  Thr Ser Ile Gln Ser  Thr Ile Ile 
    1040                 1045                 1050             


Leu Leu  Ile Glu Gln Ile Val  Val Ala Leu Gly Gly  Glu Phe Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Pro Gln Leu Ile  Pro His Met Leu Arg  Val Phe Met 
    1070                 1075                 1080             


His Asp  Asn Ser Pro Gly Arg  Ile Val Ser Ile Lys  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ile  Gln Leu Phe Gly Ala  Asn Leu Asp Asp Tyr  Leu His Leu 
    1100                 1105                 1110             


Leu Leu  Pro Pro Ile Val Lys  Leu Phe Asp Ala Pro  Glu Ala Pro 
    1115                 1120                 1125             


Leu Pro  Ser Arg Lys Ala Ala  Leu Glu Thr Val Asp  Arg Leu Thr 
    1130                 1135                 1140             


Glu Ser  Leu Asp Phe Thr Asp  Tyr Ala Ser Arg Ile  Ile His Pro 
    1145                 1150                 1155             


Ile Val  Arg Thr Leu Asp Gln  Ser Pro Glu Leu Arg  Ser Thr Ala 
    1160                 1165                 1170             


Met Asp  Thr Leu Ser Ser Leu  Val Phe Gln Leu Gly  Lys Lys Tyr 
    1175                 1180                 1185             


Gln Ile  Phe Ile Pro Met Val  Asn Lys Val Leu Val  Arg His Arg 
    1190                 1195                 1200             


Ile Asn  His Gln Arg Tyr Asp  Val Leu Ile Cys Arg  Ile Val Lys 
    1205                 1210                 1215             


Gly Tyr  Thr Leu Ala Asp Glu  Glu Glu Asp Pro Leu  Ile Tyr Gln 
    1220                 1225                 1230             


His Arg  Met Leu Arg Ser Gly  Gln Gly Asp Ala Leu  Ala Ser Gly 
    1235                 1240                 1245             


Pro Val  Glu Thr Gly Pro Met  Lys Lys Leu His Val  Ser Thr Ile 
    1250                 1255                 1260             


Asn Leu  Gln Lys Ala Trp Gly  Ala Ala Arg Arg Val  Ser Lys Asp 
    1265                 1270                 1275             


Asp Trp  Leu Glu Trp Leu Arg  Arg Leu Ser Leu Glu  Leu Leu Lys 
    1280                 1285                 1290             


Asp Ser  Ser Ser Pro Ser Leu  Arg Ser Cys Trp Ala  Leu Ala Gln 
    1295                 1300                 1305             


Ala Tyr  Asn Pro Met Ala Arg  Asp Leu Phe Asn Ala  Ala Phe Val 
    1310                 1315                 1320             


Ser Cys  Trp Ser Glu Leu Asn  Glu Asp Gln Gln Asp  Glu Leu Ile 
    1325                 1330                 1335             


Arg Ser  Ile Glu Leu Ala Leu  Thr Ser Gln Asp Ile  Ala Glu Val 
    1340                 1345                 1350             


Thr Gln  Thr Leu Leu Asn Leu  Ala Glu Phe Met Glu  His Ser Asp 
    1355                 1360                 1365             


Lys Gly  Pro Leu Pro Leu Arg  Asp Asp Asn Gly Ile  Val Leu Leu 
    1370                 1375                 1380             


Gly Glu  Arg Ala Ala Lys Cys  Arg Ala Tyr Ala Lys  Ala Leu His 
    1385                 1390                 1395             


Tyr Lys  Glu Leu Glu Phe Gln  Lys Gly Pro Thr Pro  Ala Ile Leu 
    1400                 1405                 1410             


Glu Ser  Leu Ile Ser Ile Asn  Asn Lys Leu Gln Gln  Pro Glu Ala 
    1415                 1420                 1425             


Ala Ala  Gly Val Leu Glu Tyr  Ala Met Lys His Phe  Gly Glu Leu 
    1430                 1435                 1440             


Glu Ile  Gln Ala Thr Trp Tyr  Glu Lys Leu His Glu  Trp Glu Asp 
    1445                 1450                 1455             


Ala Leu  Val Ala Tyr Asp Lys  Lys Met Asp Thr Asn  Lys Asp Asp 
    1460                 1465                 1470             


Pro Glu  Leu Met Leu Gly Arg  Met Arg Cys Leu Glu  Ala Leu Gly 
    1475                 1480                 1485             


Glu Trp  Gly Gln Leu His Gln  Gln Cys Cys Glu Lys  Trp Thr Leu 
    1490                 1495                 1500             


Val Asn  Asp Glu Thr Gln Ala  Lys Met Ala Arg Met  Ala Ala Ala 
    1505                 1510                 1515             


Ala Ala  Trp Gly Leu Gly Gln  Trp Asp Ser Met Glu  Glu Tyr Thr 
    1520                 1525                 1530             


Cys Met  Ile Pro Arg Asp Thr  His Asp Gly Ala Phe  Tyr Arg Ala 
    1535                 1540                 1545             


Val Leu  Ala Leu His Gln Asp  Leu Phe Ser Leu Ala  Gln Gln Cys 
    1550                 1555                 1560             


Ile Asp  Lys Ala Arg Asp Leu  Leu Asp Ala Glu Leu  Thr Ala Met 
    1565                 1570                 1575             


Ala Gly  Glu Ser Tyr Ser Arg  Ala Tyr Gly Ala Met  Val Ser Cys 
    1580                 1585                 1590             


His Met  Leu Ser Glu Leu Glu  Glu Val Ile Gln Tyr  Lys Leu Val 
    1595                 1600                 1605             


Pro Glu  Arg Arg Glu Ile Ile  Arg Gln Ile Trp Trp  Glu Arg Leu 
    1610                 1615                 1620             


Gln Gly  Cys Gln Arg Ile Val  Glu Asp Trp Gln Lys  Ile Leu Met 
    1625                 1630                 1635             


Val Arg  Ser Leu Val Val Ser  Pro His Glu Asp Met  Arg Thr Trp 
    1640                 1645                 1650             


Leu Lys  Tyr Ala Ser Leu Cys  Gly Lys Ser Gly Arg  Leu Ala Leu 
    1655                 1660                 1665             


Ala His  Lys Thr Leu Val Leu  Leu Leu Gly Val Asp  Pro Ser Arg 
    1670                 1675                 1680             


Gln Leu  Asp His Pro Leu Pro  Thr Val His Pro Gln  Val Thr Tyr 
    1685                 1690                 1695             


Ala Tyr  Met Lys Asn Met Trp  Lys Ser Ala Arg Lys  Ile Asp Ala 
    1700                 1705                 1710             


Phe Gln  His Met Gln His Phe  Val Gln Thr Met Gln  Gln Gln Ala 
    1715                 1720                 1725             


Gln His  Ala Ile Ala Thr Glu  Asp Gln Gln His Lys  Gln Glu Leu 
    1730                 1735                 1740             


His Lys  Leu Met Ala Arg Cys  Phe Leu Lys Leu Gly  Glu Trp Gln 
    1745                 1750                 1755             


Leu Asn  Leu Gln Gly Ile Asn  Glu Ser Thr Ile Pro  Lys Val Leu 
    1760                 1765                 1770             


Gln Tyr  Tyr Ser Ala Ala Thr  Glu His Asp Arg Ser  Trp Tyr Lys 
    1775                 1780                 1785             


Ala Trp  His Ala Trp Ala Val  Met Asn Phe Glu Ala  Val Leu His 
    1790                 1795                 1800             


Tyr Lys  His Gln Asn Gln Ala  Arg Asp Glu Lys Lys  Lys Leu Arg 
    1805                 1810                 1815             


His Ala  Ser Gly Ala Asn Ile  Thr Asn Ala Thr Thr  Ala Ala Thr 
    1820                 1825                 1830             


Thr Ala  Ala Thr Ala Thr Thr  Thr Ala Ser Thr Glu  Gly Ser Asn 
    1835                 1840                 1845             


Ser Glu  Ser Glu Ala Glu Ser  Thr Glu Asn Ser Pro  Thr Pro Ser 
    1850                 1855                 1860             


Pro Leu  Gln Lys Lys Val Thr  Glu Asp Leu Ser Lys  Thr Leu Leu 
    1865                 1870                 1875             


Met Tyr  Thr Val Pro Ala Val  Gln Gly Phe Phe Arg  Ser Ile Ser 
    1880                 1885                 1890             


Leu Ser  Arg Gly Asn Asn Leu  Gln Asp Thr Leu Arg  Val Leu Thr 
    1895                 1900                 1905             


Leu Trp  Phe Asp Tyr Gly His  Trp Pro Asp Val Asn  Glu Ala Leu 
    1910                 1915                 1920             


Val Glu  Gly Val Lys Ala Ile  Gln Ile Asp Thr Trp  Leu Gln Val 
    1925                 1930                 1935             


Ile Pro  Gln Leu Ile Ala Arg  Ile Asp Thr Pro Arg  Pro Leu Val 
    1940                 1945                 1950             


Gly Arg  Leu Ile His Gln Leu  Leu Thr Asp Ile Gly  Arg Tyr His 
    1955                 1960                 1965             


Pro Gln  Ala Leu Ile Tyr Pro  Leu Thr Val Ala Ser  Lys Ser Thr 
    1970                 1975                 1980             


Thr Thr  Ala Arg His Asn Ala  Ala Asn Lys Ile Leu  Lys Asn Met 
    1985                 1990                 1995             


Cys Glu  His Ser Asn Thr Leu  Val Gln Gln Ala Met  Met Val Ser 
    2000                 2005                 2010             


Glu Glu  Leu Ile Arg Val Ala  Ile Leu Trp His Glu  Met Trp His 
    2015                 2020                 2025             


Glu Gly  Leu Glu Glu Ala Ser  Arg Leu Tyr Phe Gly  Glu Arg Asn 
    2030                 2035                 2040             


Val Lys  Gly Met Phe Glu Val  Leu Glu Pro Leu His  Ala Met Met 
    2045                 2050                 2055             


Glu Arg  Gly Pro Gln Thr Leu  Lys Glu Thr Ser Phe  Asn Gln Ala 
    2060                 2065                 2070             


Tyr Gly  Arg Asp Leu Met Glu  Ala Gln Glu Trp Cys  Arg Lys Tyr 
    2075                 2080                 2085             


Met Lys  Ser Gly Asn Val Lys  Asp Leu Thr Gln Ala  Trp Asp Leu 
    2090                 2095                 2100             


Tyr Tyr  His Val Phe Arg Arg  Ile Ser Lys Gln Leu  Pro Gln Leu 
    2105                 2110                 2115             


Thr Ser  Leu Glu Leu Gln Tyr  Val Ser Pro Lys Leu  Leu Met Cys 
    2120                 2125                 2130             


Arg Asp  Leu Glu Leu Ala Val  Pro Gly Thr Tyr Asp  Pro Asn Gln 
    2135                 2140                 2145             


Pro Ile  Ile Arg Ile Gln Ser  Ile Ala Pro Ser Leu  Gln Val Ile 
    2150                 2155                 2160             


Thr Ser  Lys Gln Arg Pro Arg  Lys Leu Thr Leu Met  Gly Ser Asn 
    2165                 2170                 2175             


Gly His  Glu Phe Val Phe Leu  Leu Lys Gly His Glu  Asp Leu Arg 
    2180                 2185                 2190             


Gln Asp  Glu Arg Val Met Gln  Leu Phe Gly Leu Val  Asn Thr Leu 
    2195                 2200                 2205             


Leu Ala  Asn Asp Pro Thr Ser  Leu Arg Lys Asn Leu  Ser Ile Gln 
    2210                 2215                 2220             


Arg Tyr  Ala Val Ile Pro Leu  Ser Thr Asn Ser Gly  Leu Ile Gly 
    2225                 2230                 2235             


Trp Val  Pro His Cys Asp Thr  Leu His Ala Leu Ile  Arg Asp Tyr 
    2240                 2245                 2250             


Arg Glu  Lys Lys Lys Ile Leu  Leu Asn Ile Glu His  Arg Ile Met 
    2255                 2260                 2265             


Leu Arg  Met Ala Pro Asp Tyr  Asp His Leu Thr Leu  Met Gln Lys 
    2270                 2275                 2280             


Val Glu  Val Phe Glu His Ala  Val Asn Asn Thr Ala  Gly Asp Asp 
    2285                 2290                 2295             


Leu Ala  Lys Leu Leu Trp Leu  Lys Ser Pro Ser Ser  Glu Val Trp 
    2300                 2305                 2310             


Phe Asp  Arg Arg Thr Asn Tyr  Thr Arg Ser Leu Ala  Val Met Ser 
    2315                 2320                 2325             


Met Val  Gly Tyr Ile Leu Gly  Leu Gly Asp Arg His  Pro Ser Asn 
    2330                 2335                 2340             


Leu Met  Leu Asp Arg Leu Ser  Gly Lys Ile Leu His  Ile Asp Phe 
    2345                 2350                 2355             


Gly Asp  Cys Phe Glu Val Ala  Met Thr Arg Glu Lys  Phe Pro Glu 
    2360                 2365                 2370             


Lys Ile  Pro Phe Arg Leu Thr  Arg Met Leu Thr Asn  Ala Met Glu 
    2375                 2380                 2385             


Val Thr  Gly Leu Asp Gly Asn  Tyr Arg Ile Thr Cys  His Thr Val 
    2390                 2395                 2400             


Met Glu  Val Leu Arg Glu His  Lys Asp Ser Val Met  Ala Val Leu 
    2405                 2410                 2415             


Glu Ala  Phe Val Tyr Asp Pro  Leu Leu Asn Trp Arg  Leu Met Asp 
    2420                 2425                 2430             


Thr Asn  Thr Lys Gly Asn Lys  Arg Ser Arg Thr Arg  Thr Asp Ser 
    2435                 2440                 2445             


Tyr Ser  Ala Gly Gln Ser Val  Glu Ile Leu Asp Gly  Val Glu Leu 
    2450                 2455                 2460             


Gly Glu  Pro Ala His Lys Lys  Thr Gly Thr Thr Val  Pro Glu Ser 
    2465                 2470                 2475             


Ile His  Ser Phe Ile Gly Asp  Gly Leu Val Lys Pro  Glu Ala Leu 
    2480                 2485                 2490             


Asn Lys  Lys Ala Ile Gln Ile  Ile Asn Arg Val Arg  Asp Lys Leu 
    2495                 2500                 2505             


Thr Gly  Arg Asp Phe Ser His  Asp Asp Thr Leu Asp  Val Pro Thr 
    2510                 2515                 2520             


Gln Val  Glu Leu Leu Ile Lys  Gln Ala Thr Ser His  Glu Asn Leu 
    2525                 2530                 2535             


Cys Gln  Cys Tyr Ile Gly Trp  Cys Pro Phe Trp 
    2540                 2545                 


<210>  10
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 


<210>  11
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Pro Lys Lys Lys Pro Thr Pro Ile Gln Leu Asn Pro Ala Pro Asp 
1               5                   10                  15      


Gly Ser Ala Val Asn Gly Thr Ser Ser Ala Glu Thr Asn Leu Glu Ala 
            20                  25                  30          


Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp Glu Gln Gln Arg Lys 
        35                  40                  45              


Arg Leu Glu Ala Phe Leu Thr Gln Lys Gln Lys Val Gly Glu Leu Lys 
    50                  55                  60                  


Asp Asp Asp Phe Glu Lys Ile Ser Glu Leu Gly Ala Gly Asn Gly Gly 
65                  70                  75                  80  


Val Val Phe Lys Val Ser His Lys Pro Ser Gly Leu Val Met Ala Arg 
                85                  90                  95      


Lys Leu Ile His Leu Glu Ile Lys Pro Ala Ile Arg Asn Gln Ile Ile 
            100                 105                 110         


Arg Glu Leu Gln Val Leu His Glu Cys Asn Ser Pro Tyr Ile Val Gly 
        115                 120                 125             


Phe Tyr Gly Ala Phe Tyr Ser Asp Gly Glu Ile Ser Ile Cys Met Glu 
    130                 135                 140                 


His Met Asp Gly Gly Ser Leu Asp Gln Val Leu Lys Lys Ala Gly Arg 
145                 150                 155                 160 


Ile Pro Glu Gln Ile Leu Gly Lys Val Ser Ile Ala Val Ile Lys Gly 
                165                 170                 175     


Leu Thr Tyr Leu Arg Glu Lys His Lys Ile Met His Arg Asp Val Lys 
            180                 185                 190         


Pro Ser Asn Ile Leu Val Asn Ser Arg Gly Glu Ile Lys Leu Cys Asp 
        195                 200                 205             


Phe Gly Val Ser Gly Gln Leu Ile Asp Ser Met Ala Asn Ser Phe Val 
    210                 215                 220                 


Gly Thr Arg Ser Tyr Met Ser Pro Glu Arg Leu Gln Gly Thr His Tyr 
225                 230                 235                 240 


Ser Val Gln Ser Asp Ile Trp Ser Met Gly Leu Ser Leu Val Glu Met 
                245                 250                 255     


Ala Val Gly Arg Tyr Pro Ile Pro Pro Pro Asp Ala Lys Glu Leu Glu 
            260                 265                 270         


Leu Met Phe Gly Cys Gln Val Glu Gly Asp Ala Ala Glu Thr Pro Pro 
        275                 280                 285             


Arg Pro Arg Thr Pro Gly Arg Pro Leu Ser Ser Tyr Gly Met Asp Ser 
    290                 295                 300                 


Arg Pro Pro Met Ala Ile Phe Glu Leu Leu Asp Tyr Ile Val Asn Glu 
305                 310                 315                 320 


Pro Pro Pro Lys Leu Pro Ser Gly Val Phe Ser Leu Glu Phe Gln Asp 
                325                 330                 335     


Phe Val Asn Lys Cys Leu Ile Lys Asn Pro Ala Glu Arg Ala Asp Leu 
            340                 345                 350         


Lys Gln Leu Met Val His Ala Phe Ile Lys Arg Ser Asp Ala Glu Glu 
        355                 360                 365             


Val Asp Phe Ala Gly Trp Leu Cys Ser Thr Ile Gly Leu Asn Gln Pro 
    370                 375                 380                 


Ser Thr Pro Thr His Ala Ala Gly Val 
385                 390             


<210>  12
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Lys Leu Asn Ile Ser Phe Pro Ala Thr Gly Cys Gln Lys Leu Ile 
1               5                   10                  15      


Glu Val Asp Asp Glu Arg Lys Leu Arg Thr Phe Tyr Glu Lys Arg Met 
            20                  25                  30          


Ala Thr Glu Val Ala Ala Asp Ala Leu Gly Glu Glu Trp Lys Gly Tyr 
        35                  40                  45              


Val Val Arg Ile Ser Gly Gly Asn Asp Lys Gln Gly Phe Pro Met Lys 
    50                  55                  60                  


Gln Gly Val Leu Thr His Gly Arg Val Arg Leu Leu Leu Ser Lys Gly 
65                  70                  75                  80  


His Ser Cys Tyr Arg Pro Arg Arg Thr Gly Glu Arg Lys Arg Lys Ser 
                85                  90                  95      


Val Arg Gly Cys Ile Val Asp Ala Asn Leu Ser Val Leu Asn Leu Val 
            100                 105                 110         


Ile Val Lys Lys Gly Glu Lys Asp Ile Pro Gly Leu Thr Asp Thr Thr 
        115                 120                 125             


Val Pro Arg Arg Leu Gly Pro Lys Arg Ala Ser Arg Ile Arg Lys Leu 
    130                 135                 140                 


Phe Asn Leu Ser Lys Glu Asp Asp Val Arg Gln Tyr Val Val Arg Lys 
145                 150                 155                 160 


Pro Leu Asn Lys Glu Gly Lys Lys Pro Arg Thr Lys Ala Pro Lys Ile 
                165                 170                 175     


Gln Arg Leu Val Thr Pro Arg Val Leu Gln His Lys Arg Arg Arg Ile 
            180                 185                 190         


Ala Leu Lys Lys Gln Arg Thr Lys Lys Asn Lys Glu Glu Ala Ala Glu 
        195                 200                 205             


Tyr Ala Lys Leu Leu Ala Lys Arg Met Lys Glu Ala Lys Glu Lys Arg 
    210                 215                 220                 


Gln Glu Gln Ile Ala Lys Arg Arg Arg Leu Ser Ser Leu Arg Ala Ser 
225                 230                 235                 240 


Thr Ser Lys Ser Glu Ser Ser Gln Lys 
                245                 


<210>  13
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160 


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175     


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190         


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205             


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220                 


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240 


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255     


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270         


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285             


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300                 


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335     


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350         


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365             


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380                 


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400 


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415     


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430         


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445             


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460                 


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
465                 470                 475                 480 


<210>  14
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Phe Pro Asn Gly Thr Ala Ser Ser Pro Ser Ser Ser Pro Ser Pro 
1               5                   10                  15      


Ser Pro Gly Ser Cys Gly Glu Gly Gly Gly Ser Arg Gly Pro Gly Ala 
            20                  25                  30          


Gly Ala Ala Asp Gly Met Glu Glu Pro Gly Arg Asn Ala Ser Gln Asn 
        35                  40                  45              


Gly Thr Leu Ser Glu Gly Gln Gly Ser Ala Ile Leu Ile Ser Phe Ile 
    50                  55                  60                  


Tyr Ser Val Val Cys Leu Val Gly Leu Cys Gly Asn Ser Met Val Ile 
65                  70                  75                  80  


Tyr Val Ile Leu Arg Tyr Ala Lys Met Lys Thr Ala Thr Asn Ile Tyr 
                85                  90                  95      


Ile Leu Asn Leu Ala Ile Ala Asp Glu Leu Leu Met Leu Ser Val Pro 
            100                 105                 110         


Phe Leu Val Thr Ser Thr Leu Leu Arg His Trp Pro Phe Gly Ala Leu 
        115                 120                 125             


Leu Cys Arg Leu Val Leu Ser Val Asp Ala Val Asn Met Phe Thr Ser 
    130                 135                 140                 


Ile Tyr Cys Leu Thr Val Leu Ser Val Asp Arg Tyr Val Ala Val Val 
145                 150                 155                 160 


His Pro Ile Lys Ala Ala Arg Tyr Arg Arg Pro Thr Val Ala Lys Val 
                165                 170                 175     


Val Asn Leu Gly Val Trp Val Leu Ser Leu Leu Val Ile Leu Pro Ile 
            180                 185                 190         


Val Val Phe Ser Arg Thr Ala Ala Asn Ser Asp Gly Thr Val Ala Cys 
        195                 200                 205             


Asn Met Leu Met Pro Glu Pro Ala Gln Arg Trp Leu Val Gly Phe Val 
    210                 215                 220                 


Leu Tyr Thr Phe Leu Met Gly Phe Leu Leu Pro Val Gly Ala Ile Cys 
225                 230                 235                 240 


Leu Cys Tyr Val Leu Ile Ile Ala Lys Met Arg Met Val Ala Leu Lys 
                245                 250                 255     


Ala Gly Trp Gln Gln Arg Lys Arg Ser Glu Arg Lys Ile Thr Leu Met 
            260                 265                 270         


Val Met Met Val Val Met Val Phe Val Ile Cys Trp Met Pro Phe Tyr 
        275                 280                 285             


Val Val Gln Leu Val Asn Val Phe Ala Glu Gln Asp Asp Ala Thr Val 
    290                 295                 300                 


Ser Gln Leu Ser Val Ile Leu Gly Tyr Ala Asn Ser Cys Ala Asn Pro 
305                 310                 315                 320 


Ile Leu Tyr Gly Phe Leu Ser Asp Asn Phe Lys Arg Ser Phe Gln Arg 
                325                 330                 335     


Ile Leu Cys Leu Ser Trp Met Asp Asn Ala Ala Glu Glu Pro Val Asp 
            340                 345                 350         


Tyr Tyr Ala Thr Ala Leu Lys Ser Arg Ala Tyr Ser Val Glu Asp Phe 
        355                 360                 365             


Gln Pro Glu Asn Leu Glu Ser Gly Gly Val Phe Arg Asn Gly Thr Cys 
    370                 375                 380                 


Thr Ser Arg Ile Thr Thr Leu 
385                 390     


<210>  15
<211>  1852
<212>  DNA
<213>  Homo sapiens

<400>  15
accgccgaga ccgcgtccgc cccgcgagca cagagcctcg cctttgccga tccgccgccc     60

gtccacaccc gccgccagct caccatggat gatgatatcg ccgcgctcgt cgtcgacaac    120

ggctccggca tgtgcaaggc cggcttcgcg ggcgacgatg ccccccgggc cgtcttcccc    180

tccatcgtgg ggcgccccag gcaccagggc gtgatggtgg gcatgggtca gaaggattcc    240

tatgtgggcg acgaggccca gagcaagaga ggcatcctca ccctgaagta ccccatcgag    300

cacggcatcg tcaccaactg ggacgacatg gagaaaatct ggcaccacac cttctacaat    360

gagctgcgtg tggctcccga ggagcacccc gtgctgctga ccgaggcccc cctgaacccc    420

aaggccaacc gcgagaagat gacccagatc atgtttgaga ccttcaacac cccagccatg    480

tacgttgcta tccaggctgt gctatccctg tacgcctctg gccgtaccac tggcatcgtg    540

atggactccg gtgacggggt cacccacact gtgcccatct acgaggggta tgccctcccc    600

catgccatcc tgcgtctgga cctggctggc cgggacctga ctgactacct catgaagatc    660

ctcaccgagc gcggctacag cttcaccacc acggccgagc gggaaatcgt gcgtgacatt    720

aaggagaagc tgtgctacgt cgccctggac ttcgagcaag agatggccac ggctgcttcc    780

agctcctccc tggagaagag ctacgagctg cctgacggcc aggtcatcac cattggcaat    840

gagcggttcc gctgccctga ggcactcttc cagccttcct tcctgggcat ggagtcctgt    900

ggcatccacg aaactacctt caactccatc atgaagtgtg acgtggacat ccgcaaagac    960

ctgtacgcca acacagtgct gtctggcggc accaccatgt accctggcat tgccgacagg   1020

atgcagaagg agatcactgc cctggcaccc agcacaatga agatcaagat cattgctcct   1080

cctgagcgca agtactccgt gtggatcggc ggctccatcc tggcctcgct gtccaccttc   1140

cagcagatgt ggatcagcaa gcaggagtat gacgagtccg gcccctccat cgtccaccgc   1200

aaatgcttct aggcggacta tgacttagtt gcgttacacc ctttcttgac aaaacctaac   1260

ttgcgcagaa aacaagatga gattggcatg gctttatttg ttttttttgt tttgttttgg   1320

tttttttttt ttttttggct tgactcagga tttaaaaact ggaacggtga aggtgacagc   1380

agtcggttgg agcgagcatc ccccaaagtt cacaatgtgg ccgaggactt tgattgcaca   1440

ttgttgtttt tttaatagtc attccaaata tgagatgcgt tgttacagga agtcccttgc   1500

catcctaaaa gccaccccac ttctctctaa ggagaatggc ccagtcctct cccaagtcca   1560

cacaggggag gtgatagcat tgctttcgtg taaattatgt aatgcaaaat ttttttaatc   1620

ttcgccttaa tactttttta ttttgtttta ttttgaatga tgagccttcg tgccccccct   1680

tccccctttt ttgtccccca acttgagatg tatgaaggct tttggtctcc ctgggagtgg   1740

gtggaggcag ccagggctta cctgtacact gacttgagac cagttgaata aaagtgcaca   1800

ccttaaaaat gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa           1852


<210>  16
<211>  1310
<212>  DNA
<213>  Homo sapiens

<400>  16
aaattgagcc cgcagcctcc cgcttcgctc tctgctcctc ctgttcgaca gtcagccgca     60

tcttcttttg cgtcgccagc cgagccacat cgctcagaca ccatggggaa ggtgaaggtc    120

ggagtcaacg gatttggtcg tattgggcgc ctggtcacca gggctgcttt taactctggt    180

aaagtggata ttgttgccat caatgacccc ttcattgacc tcaactacat ggtttacatg    240

ttccaatatg attccaccca tggcaaattc catggcaccg tcaaggctga gaacgggaag    300

cttgtcatca atggaaatcc catcaccatc ttccaggagc gagatccctc caaaatcaag    360

tggggcgatg ctggcgctga gtacgtcgtg gagtccactg gcgtcttcac caccatggag    420

aaggctgggg ctcatttgca ggggggagcc aaaagggtca tcatctctgc cccctctgct    480

gatgccccca tgttcgtcat gggtgtgaac catgagaagt atgacaacag cctcaagatc    540

atcagcaatg cctcctgcac caccaactgc ttagcacccc tggccaaggt catccatgac    600

aactttggta tcgtggaagg actcatgacc acagtccatg ccatcactgc cacccagaag    660

actgtggatg gcccctccgg gaaactgtgg cgtgatggcc gcggggctct ccagaacatc    720

atccctgcct ctactggcgc tgccaaggct gtgggcaagg tcatccctga gctgaacggg    780

aagctcactg gcatggcctt ccgtgtcccc actgccaacg tgtcagtggt ggacctgacc    840

tgccgtctag aaaaacctgc caaatatgat gacatcaaga aggtggtgaa gcaggcgtcg    900

gagggccccc tcaagggcat cctgggctac actgagcacc aggtggtctc ctctgacttc    960

aacagcgaca cccactcctc cacctttgac gctggggctg gcattgccct caacgaccac   1020

tttgtcaagc tcatttcctg gtatgacaac gaatttggct acagcaacag ggtggtggac   1080

ctcatggccc acatggcctc caaggagtaa gacccctgga ccaccagccc cagcaagagc   1140

acaagaggaa gagagagacc ctcactgctg gggagtccct gccacactca gtcccccacc   1200

acactgaatc tcccctcctc acagttgcca tgtagacccc ttgaagaggg gaggggccta   1260

gggagccgca ccttgtcatg taccatcaat aaagtaccct gtgctcaacc              1310


<210>  17
<211>  2245
<212>  DNA
<213>  Homo sapiens

<400>  17
acgcgacccg ccctacgggc acctcccgcg cttttcttag cgccgcagac ggtggccgag     60

cgggggaccg ggaagcatgg cccgggggtc ggcggttgcc tgggcggcgc tcgggccgtt    120

gttgtggggc tgcgcgctgg ggctgcaggg cgggatgctg tacccccagg agagcccgtc    180

gcgggagtgc aaggagctgg acggcctctg gagcttccgc gccgacttct ctgacaaccg    240

acgccggggc ttcgaggagc agtggtaccg gcggccgctg tgggagtcag gccccaccgt    300

ggacatgcca gttccctcca gcttcaatga catcagccag gactggcgtc tgcggcattt    360

tgtcggctgg gtgtggtacg aacgggaggt gatcctgccg gagcgatgga cccaggacct    420

gcgcacaaga gtggtgctga ggattggcag tgcccattcc tatgccatcg tgtgggtgaa    480

tggggtcgac acgctagagc atgagggggg ctacctcccc ttcgaggccg acatcagcaa    540

cctggtccag gtggggcccc tgccctcccg gctccgaatc actatcgcca tcaacaacac    600

actcaccccc accaccctgc caccagggac catccaatac ctgactgaca cctccaagta    660

tcccaagggt tactttgtcc agaacacata ttttgacttt ttcaactacg ctggactgca    720

gcggtctgta cttctgtaca cgacacccac cacctacatc gatgacatca ccgtcaccac    780

cagcgtggag caagacagtg ggctggtgaa ttaccagatc tctgtcaagg gcagtaacct    840

gttcaagttg gaagtgcgtc ttttggatgc agaaaacaaa gtcgtggcga atgggactgg    900

gacccagggc caacttaagg tgccaggtgt cagcctctgg tggccgtacc tgatgcacga    960

acgccctgcc tatctgtatt cattggaggt gcagctgact gcacagacgt cactggggcc   1020

tgtgtctgac ttctacacac tccctgtggg gatccgcact gtggctgtca ccaagagcca   1080

gttcctcatc aatgggaaac ctttctattt ccacggtgtc aacaagcatg aggatgcgga   1140

catccgaggg aagggcttcg actggccgct gctggtgaag gacttcaacc tgcttcgctg   1200

gcttggtgcc aacgctttcc gtaccagcca ctacccctat gcagaggaag tgatgcagat   1260

gtgtgaccgc tatgggattg tggtcatcga tgagtgtccc ggcgtgggcc tggcgctgcc   1320

gcagttcttc aacaacgttt ctctgcatca ccacatgcag gtgatggaag aagtggtgcg   1380

tagggacaag aaccaccccg cggtcgtgat gtggtctgtg gccaacgagc ctgcgtccca   1440

cctagaatct gctggctact acttgaagat ggtgatcgct cacaccaaat ccttggaccc   1500

ctcccggcct gtgacctttg tgagcaactc taactatgca gcagacaagg gggctccgta   1560

tgtggatgtg atctgtttga acagctacta ctcttggtat cacgactacg ggcacctgga   1620

gttgattcag ctgcagctgg ccacccagtt tgagaactgg tataagaagt atcagaagcc   1680

cattattcag agcgagtatg gagcagaaac gattgcaggg tttcaccagg atccacctct   1740

gatgttcact gaagagtacc agaaaagtct gctagagcag taccatctgg gtctggatca   1800

aaaacgcaga aaatacgtgg ttggagagct catttggaat tttgccgatt tcatgactga   1860

acagtcaccg acgagagtgc tggggaataa aaaggggatc ttcactcggc agagacaacc   1920

aaaaagtgca gcgttccttt tgcgagagag atactggaag attgccaatg aaaccaggta   1980

tccccactca gtagccaagt cacaatgttt ggaaaacagc ccgtttactt gagcaagact   2040

gataccacct gcgtgtccct tcctccccga gtcagggcga cttccacagc agcagaacaa   2100

gtgcctcctg gactgttcac ggcagaccag aacgtttctg gcctgggttt tgtggtcatc   2160

tattctagca gggaacacta aaggtggaaa taaaagattt tctattatgg aaataaagag   2220

ttggcatgaa agtggctact gaaaa                                         2245


<210>  18
<211>  1229
<212>  DNA
<213>  Homo sapiens

<400>  18
gtctgacggg cgatggcgca gccaatagac aggagcgcta tccgcggttt ctgattggct     60

actttgttcg cattataaaa ggcacgcgcg ggcgcgaggc ccttctctcg ccaggcgtcc    120

tcgtggaagt gacatcgtct ttaaaccctg cgtggcaatc cctgacgcac cgccgtgatg    180

cccagggaag acagggcgac ctggaagtcc aactacttcc ttaagatcat ccaactattg    240

gatgattatc cgaaatgttt cattgtggga gcagacaatg tgggctccaa gcagatgcag    300

cagatccgca tgtcccttcg cgggaaggct gtggtgctga tgggcaagaa caccatgatg    360

cgcaaggcca tccgagggca cctggaaaac aacccagctc tggagaaact gctgcctcat    420

atccggggga atgtgggctt tgtgttcacc aaggaggacc tcactgagat cagggacatg    480

ttgctggcca ataaggtgcc agctgctgcc cgtgctggtg ccattgcccc atgtgaagtc    540

actgtgccag cccagaacac tggtctcggg cccgagaaga cctccttttt ccaggcttta    600

ggtatcacca ctaaaatctc caggggcacc attgaaatcc tgagtgatgt gcagctgatc    660

aagactggag acaaagtggg agccagcgaa gccacgctgc tgaacatgct caacatctcc    720

cccttctcct ttgggctggt catccagcag gtgttcgaca atggcagcat ctacaaccct    780

gaagtgcttg atatcacaga ggaaactctg cattctcgct tcctggaggg tgtccgcaat    840

gttgccagtg tctgtctgca gattggctac ccaactgttg catcagtacc ccattctatc    900

atcaacgggt acaaacgagt cctggccttg tctgtggaga cggattacac cttcccactt    960

gctgaaaagg tcaaggcctt cttggctgat ccatctgcct ttgtggctgc tgcccctgtg   1020

gctgctgcca ccacagctgc tcctgctgct gctgcagccc cagctaaggt tgaagccaag   1080

gaagagtcgg aggagtcgga cgaggatatg ggatttggtc tctttgacta atcaccaaaa   1140

agcaaccaac ttagccagtt ttatttgcaa aacaaggaaa taaaggctta cttctttaaa   1200

aagtaaaaaa aaaaaaaaaa aaaaaaaaa                                     1229


<210>  19
<211>  5010
<212>  DNA
<213>  Homo sapiens

<400>  19
ggcggctcgg gacggaggac gcgctagtgt gagtgcgggc ttctagaact acaccgaccc     60

tcgtgtcctc ccttcatcct gcggggctgg ctggagcggc cgctccggtg ctgtccagca    120

gccataggga gccgcacggg gagcgggaaa gcggtcgcgg ccccaggcgg ggcggccggg    180

atggagcggg gccgcgagcc tgtggggaag gggctgtggc ggcgcctcga gcggctgcag    240

gttcttctgt gtggcagttc agaatgatgg atcaagctag atcagcattc tctaacttgt    300

ttggtggaga accattgtca tatacccggt tcagcctggc tcggcaagta gatggcgata    360

acagtcatgt ggagatgaaa cttgctgtag atgaagaaga aaatgctgac aataacacaa    420

aggccaatgt cacaaaacca aaaaggtgta gtggaagtat ctgctatggg actattgctg    480

tgatcgtctt tttcttgatt ggatttatga ttggctactt gggctattgt aaaggggtag    540

aaccaaaaac tgagtgtgag agactggcag gaaccgagtc tccagtgagg gaggagccag    600

gagaggactt ccctgcagca cgtcgcttat attgggatga cctgaagaga aagttgtcgg    660

agaaactgga cagcacagac ttcaccagca ccatcaagct gctgaatgaa aattcatatg    720

tccctcgtga ggctggatct caaaaagatg aaaatcttgc gttgtatgtt gaaaatcaat    780

ttcgtgaatt taaactcagc aaagtctggc gtgatcaaca ttttgttaag attcaggtca    840

aagacagcgc tcaaaactcg gtgatcatag ttgataagaa cggtagactt gtttacctgg    900

tggagaatcc tgggggttat gtggcgtata gtaaggctgc aacagttact ggtaaactgg    960

tccatgctaa ttttggtact aaaaaagatt ttgaggattt atacactcct gtgaatggat   1020

ctatagtgat tgtcagagca gggaaaatca cctttgcaga aaaggttgca aatgctgaaa   1080

gcttaaatgc aattggtgtg ttgatataca tggaccagac taaatttccc attgttaacg   1140

cagaactttc attctttgga catgctcatc tggggacagg tgacccttac acacctggat   1200

tcccttcctt caatcacact cagtttccac catctcggtc atcaggattg cctaatatac   1260

ctgtccagac aatctccaga gctgctgcag aaaagctgtt tgggaatatg gaaggagact   1320

gtccctctga ctggaaaaca gactctacat gtaggatggt aacctcagaa agcaagaatg   1380

tgaagctcac tgtgagcaat gtgctgaaag agataaaaat tcttaacatc tttggagtta   1440

ttaaaggctt tgtagaacca gatcactatg ttgtagttgg ggcccagaga gatgcatggg   1500

gccctggagc tgcaaaatcc ggtgtaggca cagctctcct attgaaactt gcccagatgt   1560

tctcagatat ggtcttaaaa gatgggtttc agcccagcag aagcattatc tttgccagtt   1620

ggagtgctgg agactttgga tcggttggtg ccactgaatg gctagaggga tacctttcgt   1680

ccctgcattt aaaggctttc acttatatta atctggataa agcggttctt ggtaccagca   1740

acttcaaggt ttctgccagc ccactgttgt atacgcttat tgagaaaaca atgcaaaatg   1800

tgaagcatcc ggttactggg caatttctat atcaggacag caactgggcc agcaaagttg   1860

agaaactcac tttagacaat gctgctttcc ctttccttgc atattctgga atcccagcag   1920

tttctttctg tttttgcgag gacacagatt atccttattt gggtaccacc atggacacct   1980

ataaggaact gattgagagg attcctgagt tgaacaaagt ggcacgagca gctgcagagg   2040

tcgctggtca gttcgtgatt aaactaaccc atgatgttga attgaacctg gactatgaga   2100

ggtacaacag ccaactgctt tcatttgtga gggatctgaa ccaatacaga gcagacataa   2160

aggaaatggg cctgagttta cagtggctgt attctgctcg tggagacttc ttccgtgcta   2220

cttccagact aacaacagat ttcgggaatg ctgagaaaac agacagattt gtcatgaaga   2280

aactcaatga tcgtgtcatg agagtggagt atcacttcct ctctccctac gtatctccaa   2340

aagagtctcc tttccgacat gtcttctggg gctccggctc tcacacgctg ccagctttac   2400

tggagaactt gaaactgcgt aaacaaaata acggtgcttt taatgaaacg ctgttcagaa   2460

accagttggc tctagctact tggactattc agggagctgc aaatgccctc tctggtgacg   2520

tttgggacat tgacaatgag ttttaaatgt gatacccata gcttccatga gaacagcagg   2580

gtagtctggt ttctagactt gtgctgatcg tgctaaattt tcagtagggc tacaaaacct   2640

gatgttaaaa ttccatccca tcatcttggt actactagat gtctttaggc agcagctttt   2700

aatacagggt agataacctg tacttcaagt taaagtgaat aaccacttaa aaaatgtcca   2760

tgatggaata ttcccctatc tctagaattt taagtgcttt gtaatgggaa ctgcctcttt   2820

cctgttgttg ttaatgaaaa tgtcagaaac cagttatgtg aatgatctct ctgaatccta   2880

agggctggtc tctgctgaag gttgtaagtg gttcgcttac tttgagtgat cctccaactt   2940

catttgatgc taaataggag ataccaggtt gaaagacctc tccaaatgag atctaagcct   3000

ttccataagg aatgtagcag gtttcctcat tcctgaaaga aacagttaac tttcagaaga   3060

gatgggcttg ttttcttgcc aatgaggtct gaaatggagg tccttctgct ggataaaatg   3120

aggttcaact gttgattgca ggaataaggc cttaatatgt taacctcagt gtcatttatg   3180

aaaagagggg accagaagcc aaagacttag tatattttct tttcctctgt cccttccccc   3240

ataagcctcc atttagttct ttgttatttt tgtttcttcc aaagcacatt gaaagagaac   3300

cagtttcagg tgtttagttg cagactcagt ttgtcagact ttaaagaata atatgctgcc   3360

aaattttggc caaagtgtta atcttagggg agagctttct gtccttttgg cactgagata   3420

tttattgttt atttatcagt gacagagttc actataaatg gtgttttttt aatagaatat   3480

aattatcgga agcagtgcct tccataatta tgacagttat actgtcggtt ttttttaaat   3540

aaaagcagca tctgctaata aaacccaaca gatactggaa gttttgcatt tatggtcaac   3600

acttaagggt tttagaaaac agccgtcagc caaatgtaat tgaataaagt tgaagctaag   3660

atttagagat gaattaaatt taattagggg ttgctaagaa gcgagcactg accagataag   3720

aatgctggtt ttcctaaatg cagtgaattg tgaccaagtt ataaatcaat gtcacttaaa   3780

ggctgtggta gtactcctgc aaaattttat agctcagttt atccaaggtg taactctaat   3840

tcccatttgc aaaatttcca gtacctttgt cacaatccta acacattatc gggagcagtg   3900

tcttccataa tgtataaaga acaaggtagt ttttacctac cacagtgtct gtatcggaga   3960

cagtgatctc catatgttac actaagggtg taagtaatta tcgggaacag tgtttcccat   4020

aattttcttc atgcaatgac atcttcaaag cttgaagatc gttagtatct aacatgtatc   4080

ccaactccta taattcccta tcttttagtt ttagttgcag aaacattttg tggtcattaa   4140

gcattgggtg ggtaaattca accactgtaa aatgaaatta ctacaaaatt tgaaatttag   4200

cttgggtttt tgttaccttt atggtttctc caggtcctct acttaatgag atagcagcat   4260

acatttataa tgtttgctat tgacaagtca ttttaattta tcacattatt tgcatgttac   4320

ctcctataaa cttagtgcgg acaagtttta atccagaatt gaccttttga cttaaagcag   4380

agggactttg tatagaaggt ttgggggctg tggggaagga gagtcccctg aaggtctgac   4440

acgtctgcct acccattcgt ggtgatcaat taaatgtagg tatgaataag ttcgaagctc   4500

cgtgagtgaa ccatcatata aacgtgtagt acagctgttt gtcatagggc agttggaaac   4560

ggcctcctag ggaaaagttc atagggtctc ttcaggttct tagtgtcact tacctagatt   4620

tacagcctca cttgaatgtg tcactactca cagtctcttt aatcttcagt tttatcttta   4680

atctcctctt ttatcttgga ctgacattta gcgtagctaa gtgaaaaggt catagctgag   4740

attcctggtt cgggtgttac gcacacgtac ttaaatgaaa gcatgtggca tgttcatcgt   4800

ataacacaat atgaatacag ggcatgcatt ttgcagcagt gagtctcttc agaaaaccct   4860

tttctacagt tagggttgag ttacttccta tcaagccagt acgtgctaac aggctcaata   4920

ttcctgaatg aaatatcaga ctagtgacaa gctcctggtc ttgagatgtc ttctcgttaa   4980

ggagtagggc cttttggagg taaaggtata                                    5010


<210>  20
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  21
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly Arg 
1               5                   10                  15      


Leu Val Thr Arg Ala Ala Phe Asn Ser Gly Lys Val Asp Ile Val Ala 
            20                  25                  30          


Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr Met Phe Gln 
        35                  40                  45              


Tyr Asp Ser Thr His Gly Lys Phe His Gly Thr Val Lys Ala Glu Asn 
    50                  55                  60                  


Gly Lys Leu Val Ile Asn Gly Asn Pro Ile Thr Ile Phe Gln Glu Arg 
65                  70                  75                  80  


Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala Gly Ala Glu Tyr Val Val 
                85                  90                  95      


Glu Ser Thr Gly Val Phe Thr Thr Met Glu Lys Ala Gly Ala His Leu 
            100                 105                 110         


Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser Ala Asp Ala 
        115                 120                 125             


Pro Met Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Ser Leu 
    130                 135                 140                 


Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu 
145                 150                 155                 160 


Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr 
                165                 170                 175     


Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser 
            180                 185                 190         


Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile Pro 
        195                 200                 205             


Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu 
    210                 215                 220                 


Asn Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn Val 
225                 230                 235                 240 


Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp 
                245                 250                 255     


Asp Ile Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly 
            260                 265                 270         


Ile Leu Gly Tyr Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Ser 
        275                 280                 285             


Asp Thr His Ser Ser Thr Phe Asp Ala Gly Ala Gly Ile Ala Leu Asn 
    290                 295                 300                 


Asp His Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr 
305                 310                 315                 320 


Ser Asn Arg Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu 
                325                 330                 335 


<210>  22
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Arg Gly Ser Ala Val Ala Trp Ala Ala Leu Gly Pro Leu Leu 
1               5                   10                  15      


Trp Gly Cys Ala Leu Gly Leu Gln Gly Gly Met Leu Tyr Pro Gln Glu 
            20                  25                  30          


Ser Pro Ser Arg Glu Cys Lys Glu Leu Asp Gly Leu Trp Ser Phe Arg 
        35                  40                  45              


Ala Asp Phe Ser Asp Asn Arg Arg Arg Gly Phe Glu Glu Gln Trp Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Trp Glu Ser Gly Pro Thr Val Asp Met Pro Val Pro 
65                  70                  75                  80  


Ser Ser Phe Asn Asp Ile Ser Gln Asp Trp Arg Leu Arg His Phe Val 
                85                  90                  95      


Gly Trp Val Trp Tyr Glu Arg Glu Val Ile Leu Pro Glu Arg Trp Thr 
            100                 105                 110         


Gln Asp Leu Arg Thr Arg Val Val Leu Arg Ile Gly Ser Ala His Ser 
        115                 120                 125             


Tyr Ala Ile Val Trp Val Asn Gly Val Asp Thr Leu Glu His Glu Gly 
    130                 135                 140                 


Gly Tyr Leu Pro Phe Glu Ala Asp Ile Ser Asn Leu Val Gln Val Gly 
145                 150                 155                 160 


Pro Leu Pro Ser Arg Leu Arg Ile Thr Ile Ala Ile Asn Asn Thr Leu 
                165                 170                 175     


Thr Pro Thr Thr Leu Pro Pro Gly Thr Ile Gln Tyr Leu Thr Asp Thr 
            180                 185                 190         


Ser Lys Tyr Pro Lys Gly Tyr Phe Val Gln Asn Thr Tyr Phe Asp Phe 
        195                 200                 205             


Phe Asn Tyr Ala Gly Leu Gln Arg Ser Val Leu Leu Tyr Thr Thr Pro 
    210                 215                 220                 


Thr Thr Tyr Ile Asp Asp Ile Thr Val Thr Thr Ser Val Glu Gln Asp 
225                 230                 235                 240 


Ser Gly Leu Val Asn Tyr Gln Ile Ser Val Lys Gly Ser Asn Leu Phe 
                245                 250                 255     


Lys Leu Glu Val Arg Leu Leu Asp Ala Glu Asn Lys Val Val Ala Asn 
            260                 265                 270         


Gly Thr Gly Thr Gln Gly Gln Leu Lys Val Pro Gly Val Ser Leu Trp 
        275                 280                 285             


Trp Pro Tyr Leu Met His Glu Arg Pro Ala Tyr Leu Tyr Ser Leu Glu 
    290                 295                 300                 


Val Gln Leu Thr Ala Gln Thr Ser Leu Gly Pro Val Ser Asp Phe Tyr 
305                 310                 315                 320 


Thr Leu Pro Val Gly Ile Arg Thr Val Ala Val Thr Lys Ser Gln Phe 
                325                 330                 335     


Leu Ile Asn Gly Lys Pro Phe Tyr Phe His Gly Val Asn Lys His Glu 
            340                 345                 350         


Asp Ala Asp Ile Arg Gly Lys Gly Phe Asp Trp Pro Leu Leu Val Lys 
        355                 360                 365             


Asp Phe Asn Leu Leu Arg Trp Leu Gly Ala Asn Ala Phe Arg Thr Ser 
    370                 375                 380                 


His Tyr Pro Tyr Ala Glu Glu Val Met Gln Met Cys Asp Arg Tyr Gly 
385                 390                 395                 400 


Ile Val Val Ile Asp Glu Cys Pro Gly Val Gly Leu Ala Leu Pro Gln 
                405                 410                 415     


Phe Phe Asn Asn Val Ser Leu His His His Met Gln Val Met Glu Glu 
            420                 425                 430         


Val Val Arg Arg Asp Lys Asn His Pro Ala Val Val Met Trp Ser Val 
        435                 440                 445             


Ala Asn Glu Pro Ala Ser His Leu Glu Ser Ala Gly Tyr Tyr Leu Lys 
    450                 455                 460                 


Met Val Ile Ala His Thr Lys Ser Leu Asp Pro Ser Arg Pro Val Thr 
465                 470                 475                 480 


Phe Val Ser Asn Ser Asn Tyr Ala Ala Asp Lys Gly Ala Pro Tyr Val 
                485                 490                 495     


Asp Val Ile Cys Leu Asn Ser Tyr Tyr Ser Trp Tyr His Asp Tyr Gly 
            500                 505                 510         


His Leu Glu Leu Ile Gln Leu Gln Leu Ala Thr Gln Phe Glu Asn Trp 
        515                 520                 525             


Tyr Lys Lys Tyr Gln Lys Pro Ile Ile Gln Ser Glu Tyr Gly Ala Glu 
    530                 535                 540                 


Thr Ile Ala Gly Phe His Gln Asp Pro Pro Leu Met Phe Thr Glu Glu 
545                 550                 555                 560 


Tyr Gln Lys Ser Leu Leu Glu Gln Tyr His Leu Gly Leu Asp Gln Lys 
                565                 570                 575     


Arg Arg Lys Tyr Val Val Gly Glu Leu Ile Trp Asn Phe Ala Asp Phe 
            580                 585                 590         


Met Thr Glu Gln Ser Pro Thr Arg Val Leu Gly Asn Lys Lys Gly Ile 
        595                 600                 605             


Phe Thr Arg Gln Arg Gln Pro Lys Ser Ala Ala Phe Leu Leu Arg Glu 
    610                 615                 620                 


Arg Tyr Trp Lys Ile Ala Asn Glu Thr Arg Tyr Pro His Ser Val Ala 
625                 630                 635                 640 


Lys Ser Gln Cys Leu Glu Asn Ser Pro Phe Thr 
                645                 650     


<210>  23
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Pro Arg Glu Asp Arg Ala Thr Trp Lys Ser Asn Tyr Phe Leu Lys 
1               5                   10                  15      


Ile Ile Gln Leu Leu Asp Asp Tyr Pro Lys Cys Phe Ile Val Gly Ala 
            20                  25                  30          


Asp Asn Val Gly Ser Lys Gln Met Gln Gln Ile Arg Met Ser Leu Arg 
        35                  40                  45              


Gly Lys Ala Val Val Leu Met Gly Lys Asn Thr Met Met Arg Lys Ala 
    50                  55                  60                  


Ile Arg Gly His Leu Glu Asn Asn Pro Ala Leu Glu Lys Leu Leu Pro 
65                  70                  75                  80  


His Ile Arg Gly Asn Val Gly Phe Val Phe Thr Lys Glu Asp Leu Thr 
                85                  90                  95      


Glu Ile Arg Asp Met Leu Leu Ala Asn Lys Val Pro Ala Ala Ala Arg 
            100                 105                 110         


Ala Gly Ala Ile Ala Pro Cys Glu Val Thr Val Pro Ala Gln Asn Thr 
        115                 120                 125             


Gly Leu Gly Pro Glu Lys Thr Ser Phe Phe Gln Ala Leu Gly Ile Thr 
    130                 135                 140                 


Thr Lys Ile Ser Arg Gly Thr Ile Glu Ile Leu Ser Asp Val Gln Leu 
145                 150                 155                 160 


Ile Lys Thr Gly Asp Lys Val Gly Ala Ser Glu Ala Thr Leu Leu Asn 
                165                 170                 175     


Met Leu Asn Ile Ser Pro Phe Ser Phe Gly Leu Val Ile Gln Gln Val 
            180                 185                 190         


Phe Asp Asn Gly Ser Ile Tyr Asn Pro Glu Val Leu Asp Ile Thr Glu 
        195                 200                 205             


Glu Thr Leu His Ser Arg Phe Leu Glu Gly Val Arg Asn Val Ala Ser 
    210                 215                 220                 


Val Cys Leu Gln Ile Gly Tyr Pro Thr Val Ala Ser Val Pro His Ser 
225                 230                 235                 240 


Ile Ile Asn Gly Tyr Lys Arg Val Leu Ala Leu Ser Val Glu Thr Asp 
                245                 250                 255     


Tyr Thr Phe Pro Leu Ala Glu Lys Val Lys Ala Phe Leu Ala Asp Pro 
            260                 265                 270         


Ser Ala Phe Val Ala Ala Ala Pro Val Ala Ala Ala Thr Thr Ala Ala 
        275                 280                 285             


Pro Ala Ala Ala Ala Ala Pro Ala Lys Val Glu Ala Lys Glu Glu Ser 
    290                 295                 300                 


Glu Glu Ser Asp Glu Asp Met Gly Phe Gly Leu Phe Asp 
305                 310                 315         


<210>  24
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Ser Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 
        355                 360                 365             


Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 
705                 710                 715                 720 


Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


