                         SEQUENCE LISTING

<110>  The Government of the United States of America as 
       represented by the Secretary of the Department of Health and 
       Human Services
       Goncalvez, Ana  P.
       Purcell, Robert  H.
       Lai, Ching-Juh
 
<120>  HUMANIZED MONOCLONAL ANTIBODIES THAT SPECIFICALLY BIND AND/OR NEUTRALIZE 
       JAPANESE ENCEPHALITIS VIRUS (JEV) AND THEIR USE

<130>  4239-80933-02

<150>  US 61/123,905
<151>  2008-04-12

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinantly produced heavy chain of monoclonal antibody A3

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Val Ser Gly Thr Pro Tyr Ser Ser Tyr 
            20                  25                  30          


Val Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Phe Val Pro Ser Leu Asp Arg Ala Leu Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Leu Ser Ile Thr Ala Asp Thr Thr Thr Thr Tyr Met Glu 
65                  70                  75                  80  


Leu Thr Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
                85                  90                  95      


Asp Phe Ser Val Gly Trp Leu Arg Pro Leu Asp Arg Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  2
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinantly produced heavy chain of monoclonal antibody B2

<400>  2

Glu Val Gln Leu Leu Glu Gln Ser Gly Ser Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asp 
            20                  25                  30          


Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Tyr 
        35                  40                  45              


Met Gly Trp Ile Phe Thr Asn Ser Gly Asn Pro Thr Tyr Ala Pro Gly 
    50                  55                  60                  


Phe Ala Gly Arg Phe Val Phe Ser Leu Asp Ile Ser Val Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu His Ile Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Ile Val Thr Pro Ala Ala Ser Gly Asp Tyr Phe Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  3
<211>  123
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinantly produced heavy chain of monoclonal antibody E3

<400>  3

Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Ile Ser Gly Pro 
            20                  25                  30          


Leu Ser Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Lys Met Glu 
        35                  40                  45              


His Ile Gly Ser Met Phe Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Gly Arg Ile Thr Met Ser Val Asp Thr Ser Arg Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Asn Leu Asn Ser Val Thr Val Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Arg Arg Glu Thr Glu Leu Phe Gly Leu Pro Ile Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser 
        115                 120             


<210>  4
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinantly produced light chain of monoclonal antibody A3

<400>  4

Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Asn Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr 
            100                 105                 


<210>  5
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinantly produced light chain of monoclonal antibody B2

<400>  5

Glu Leu Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln His Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Glu Asn Ser Pro Val 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  6
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced light chain of monoclonal antibody E3

<400>  6

Glu Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg 
1               5                   10                  15      


Ala Thr Leu Ser Cys Arg Ala Ser Glu Arg Ile Ser Ser Ser Tyr Leu 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Met Tyr 
        35                  40                  45              


Gly Thr Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Phe Cys Gln Gln Asp Tyr Asn Leu Pro Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105             


<210>  7
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide primer.

<400>  7
ggagccatga agagatctaa tttccagggg                                        30


<210>  8
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide primer.

<400>  8
gcccagcgtg ctccgcggtt tgtgccaatg gtg                                    33


<210>  9
<211>  900
<212>  DNA
<213>  Japanese encephalitis virus

<400>  9
tttaattgtc tgggaatggg caatcgtgac ttcatagaag gagccagtgg agccacttgg       60

gtggacttgg tgctagaagg agacagctgc ttgacaatca tggcaaacga caaaccaaca      120

ttggacgtcc gcatgattaa catcgaagct agccaacttg ctgaggtcag aagttactgc      180

tatcatgctt cagtcactga catctcgacg gtggctcggt gccccacgac tggagaagcc      240

cacaacgaga agcgagctga tagtagctat gtgtgcaaac aaggcttcac tgaccgtggg      300

tggggcaacg gatgtggatt tttcgggaag ggaagcattg acacatgtgc aaaattctcc      360

tgcaccagta aagcgattgg gagaacaatc cagccagaaa acatcaaata caaagttggc      420

atttttgtgc atggaaccac cacttcggaa aaccatggga attattcagc gcaagttggg      480

gcgtcccagg cggcaaagtt tacagtaaca cccaatgctc cttcggtagc cctcaaactt      540

ggtgactacg gagaagtcac actggactgt gagccaagga gtggactgaa cactgaagcg      600

ttttacgtca tgaccgtggg gtcaaagtca tttctggtcc atagggagtg gtttcatgac      660

ctcgctctcc cctggacgtc cccttcgagc acagcgtgga gaaacagaga actcctcatg      720

gaatttgaag gggcgcacgc cacaaaacag tccgttgttg ctcttgggtc acaggaagga      780

ggcctccatc atgcgttggc aggagccatc gtggtggagt actcaagctc agtgatgtta      840

acatcaggcc acctgaaatg taggctgaaa atggacaaac tggctctgaa aggcacaacc      900


<210>  10
<211>  499
<212>  PRT
<213>  Japanese encephalitis virus

<400>  10

Phe Asn Cys Leu Gly Met Gly Asn Arg Asp Phe Ile Glu Gly Ala Ser 
1               5                   10                  15      


Gly Ala Thr Trp Val Asp Leu Val Leu Glu Gly Asp Ser Cys Leu Thr 
            20                  25                  30          


Ile Met Ala Asn Asp Lys Pro Thr Leu Asp Val Arg Met Ile Asn Ile 
        35                  40                  45              


Glu Ala Ser Gln Leu Ala Glu Val Arg Ser Tyr Cys Tyr His Ala Ser 
    50                  55                  60                  


Val Thr Asp Ile Ser Thr Val Ala Arg Cys Pro Thr Thr Gly Glu Ala 
65                  70                  75                  80  


His Asn Glu Lys Arg Ala Asp Ser Ser Tyr Val Cys Lys Gln Gly Phe 
                85                  90                  95      


Thr Asp Arg Gly Trp Gly Asn Gly Cys Gly Phe Phe Gly Lys Gly Ser 
            100                 105                 110         


Ile Asp Thr Cys Ala Lys Phe Ser Cys Thr Ser Lys Ala Ile Gly Arg 
        115                 120                 125             


Thr Ile Gln Pro Glu Asn Ile Lys Tyr Lys Val Gly Ile Phe Val His 
    130                 135                 140                 


Gly Thr Thr Thr Ser Glu Asn His Gly Asn Tyr Ser Ala Gln Val Gly 
145                 150                 155                 160 


Ala Ser Gln Ala Ala Lys Phe Thr Val Thr Pro Asn Ala Pro Ser Val 
                165                 170                 175     


Ala Leu Lys Leu Gly Asp Tyr Gly Glu Val Thr Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Ser Gly Leu Asn Thr Glu Ala Phe Tyr Val Met Thr Val Gly Ser 
        195                 200                 205             


Lys Ser Phe Leu Val His Arg Glu Trp Phe His Asp Leu Ala Leu Pro 
    210                 215                 220                 


Trp Thr Ser Pro Ser Ser Thr Ala Trp Arg Asn Arg Glu Leu Leu Met 
225                 230                 235                 240 


Glu Phe Glu Gly Ala His Ala Thr Lys Gln Ser Val Val Ala Leu Gly 
                245                 250                 255     


Ser Gln Glu Gly Gly Leu His His Ala Leu Ala Gly Ala Ile Val Glu 
            260                 265                 270         


Tyr Ser Ser Ser Val Met Leu Thr Ser Gly His Leu Lys Cys Arg Leu 
        275                 280                 285             


Lys Met Asp Lys Leu Ala Leu Lys Gly Thr Thr Tyr Gly Met Cys Thr 
    290                 295                 300                 


Glu Lys Phe Ser Phe Ala Lys Asn Pro Val Asp Thr Gly His Gly Thr 
305                 310                 315                 320 


Val Val Ile Glu Leu Ser Tyr Ser Gly Ser Asp Gly Pro Cys Lys Ile 
                325                 330                 335     


Pro Ile Val Ser Val Ala Ser Leu Asn Asp Met Thr Pro Val Gly Arg 
            340                 345                 350         


Leu Val Thr Val Asn Pro Phe Val Ala Thr Ser Ser Ala Asn Ser Lys 
        355                 360                 365             


Val Leu Val Glu Met Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Val 
    370                 375                 380                 


Gly Arg Gly Asp Lys Gln Ile Asn His His Trp His Lys Ala Gly Ser 
385                 390                 395                 400 


Thr Leu Gly Lys Ala Phe Ser Thr Thr Leu Lys Gly Ala Gln Arg Leu 
                405                 410                 415     


Ala Ala Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly Gly Val 
            420                 425                 430         


Phe Asn Ser Ile Gly Arg Ala Val His Gln Val Phe Gly Asp Ala Phe 
        435                 440                 445             


Arg Thr Leu Phe Gly Gly Met Ser Trp Ile Thr Gln Gly Leu Met Gly 
    450                 455                 460                 


Ala Leu Leu Leu Trp Met Gly Val Asn Ala Arg Asp Arg Ser Ile Ala 
465                 470                 475                 480 


Leu Ala Phe Leu Ala Thr Gly Gly Val Leu Val Phe Leu Ala Thr Asn 
                485                 490                 495     


Val His Ala 
            


<210>  11
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinantly produced heavy chain of monoclonal antibody A3

<400>  11

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  12
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  12

Leu Leu Gly Gly 
1               


<210>  13
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinantly produced heavy chain of monoclonal antibody A3

<400>  13

Glu Leu Leu Gly Gly 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  14

Leu Leu Gly Gly Pro 
1               5   


<210>  15
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  15

Pro Glu Leu Leu Gly Gly 
1               5       


<210>  16
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Leu Leu Gly Gly Pro 
1               5       


<210>  17
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  17

Leu Leu Gly Gly Pro Ser 
1               5       


<210>  18
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Pro Glu Leu Leu Gly Gly 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  19

Pro Glu Leu Leu Gly Gly Pro 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  20

Glu Leu Leu Gly Gly Pro Ser 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  21

Leu Leu Gly Gly Pro Ser Val 
1               5           


<210>  22
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  22

Pro Ala Pro Glu Leu Leu Gly Gly 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Pro Glu Leu Leu Gly Gly Pro 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinantly produced heavy chain of monoclonal antibody A3

<400>  24

Pro Glu Leu Leu Gly Gly Pro Ser 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  25

Glu Leu Leu Gly Gly Pro Ser Val 
1               5               


<210>  26
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  26

Pro Ala Pro Glu Leu Leu Gly Gly Pro 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Pro Glu Leu Leu Gly Gly Pro Ser 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinantly produced heavy chain of monoclonal antibody A3

<400>  28

Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   


<210>  29
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  29

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  30

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10  


<210>  31
<211>  449
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinantly produced heavy chain of monoclonal antibody A3

<400>  31

Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Val Ser Gly Thr Pro Tyr Ser Ser Tyr 
            20                  25                  30          


Val Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Phe Val Pro Ser Leu Asp Arg Ala Leu Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Leu Ser Ile Thr Ala Asp Thr Thr Thr Thr Tyr Met Glu 
65                  70                  75                  80  


Leu Thr Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
                85                  90                  95      


Asp Phe Ser Val Gly Trp Leu Arg Pro Leu Asp Arg Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Glu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  32
<211>  454
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinantly produced heavy chain of monoclonal antibody B2

<400>  32

Glu Val Gln Leu Leu Glu Gln Ser Gly Ser Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asp 
            20                  25                  30          


Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Tyr 
        35                  40                  45              


Met Gly Trp Ile Phe Thr Asn Ser Gly Asn Pro Thr Tyr Ala Pro Gly 
    50                  55                  60                  


Phe Ala Gly Arg Phe Val Phe Ser Leu Asp Ile Ser Val Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu His Ile Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Ile Val Thr Pro Ala Ala Ser Gly Asp Tyr Phe Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
225                 230                 235                 240 


Val Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  33
<211>  453
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinantly produced heavy chain of monoclonal antibody E3

<400>  33

Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Ile Ser Gly Pro 
            20                  25                  30          


Leu Ser Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Lys Met Glu 
        35                  40                  45              


His Ile Gly Ser Met Phe Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Gly Arg Ile Thr Met Ser Val Asp Thr Ser Arg Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Asn Leu Asn Ser Val Thr Val Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Arg Arg Glu Thr Glu Leu Phe Gly Leu Pro Ile Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
225                 230                 235                 240 


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  34
<211>  210
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinantly produced light chain of monoclonal antibody A3

<400>  34

Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Asn Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Asn Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn 
    210 


<210>  35
<211>  210
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinantly produced light chain of monoclonal antibody B2

<400>  35

Glu Leu Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln His Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Glu Asn Ser Pro Val 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Asn Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn 
    210 


<210>  36
<211>  209
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinantly produced light chain of monoclonal antibody E3

<400>  36

Glu Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg 
1               5                   10                  15      


Ala Thr Leu Ser Cys Arg Ala Ser Glu Arg Ile Ser Ser Ser Tyr Leu 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Met Tyr 
        35                  40                  45              


Gly Thr Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Phe Cys Gln Gln Asp Tyr Asn Leu Pro Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Asn Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             
Asn 