                         SEQUENCE LISTING

<110>  Novartis, AG
       Dai, Yumin
       Schrim, Sabine
       Hardy, Steve
 
<120>  PHARMACEUTICAL COMBINATIONS  

<130>  52632P1

<160>  14    

<170>  PatentIn version 3.3

<210>  1
<211>  276
<212>  PRT
<213>  homo sapiens

<400>  1

Asp Ser Glu Glu Asp Glu Glu His Thr Ile Ile Thr Asp Thr Glu Leu 
1               5                   10                  15      


Pro Pro Leu Lys Leu Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp 
            20                  25                  30          


Gly Pro Cys Lys Ala Ile Met Lys Arg Phe Phe Phe Asn Ile Phe Thr 
        35                  40                  45              


Arg Gln Cys Glu Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gln Asn 
    50                  55                  60                  


Arg Phe Glu Ser Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp Asn 
65                  70                  75                  80  


Ala Asn Arg Ile Ile Lys Thr Thr Leu Gln Gln Glu Lys Pro Asp Phe 
                85                  90                  95      


Cys Phe Leu Glu Glu Asp Pro Gly Ile Cys Arg Gly Tyr Ile Thr Arg 
            100                 105                 110         


Tyr Phe Tyr Asn Asn Gln Thr Lys Gln Cys Glu Arg Phe Lys Tyr Gly 
        115                 120                 125             


Gly Cys Leu Gly Asn Met Asn Asn Phe Glu Thr Leu Glu Glu Cys Lys 
    130                 135                 140                 


Asn Ile Cys Glu Asp Gly Pro Asn Gly Phe Gln Val Asp Asn Tyr Gly 
145                 150                 155                 160 


Thr Gln Leu Asn Ala Val Asn Asn Ser Leu Thr Pro Gln Ser Thr Lys 
                165                 170                 175     


Val Pro Ser Leu Phe Glu Phe His Gly Pro Ser Trp Cys Leu Thr Pro 
            180                 185                 190         


Ala Asp Arg Gly Leu Cys Arg Ala Asn Glu Asn Arg Phe Tyr Tyr Asn 
        195                 200                 205             


Ser Val Ile Gly Lys Cys Arg Pro Phe Lys Tyr Ser Gly Cys Gly Gly 
    210                 215                 220                 


Asn Glu Asn Asn Phe Thr Ser Lys Gln Glu Cys Leu Arg Ala Cys Lys 
225                 230                 235                 240 


Lys Gly Phe Ile Gln Arg Ile Ser Lys Gly Gly Leu Ile Lys Thr Lys 
                245                 250                 255     


Arg Lys Arg Lys Lys Gln Arg Val Lys Ile Ala Tyr Glu Glu Ile Phe 
            260                 265                 270         


Val Lys Asn Met 
        275     


<210>  2
<211>  277
<212>  PRT
<213>  homo sapiens

<400>  2

Ala Asp Ser Glu Glu Asp Glu Glu His Thr Ile Ile Thr Asp Thr Glu 
1               5                   10                  15      


Leu Pro Pro Leu Lys Leu Met His Ser Phe Cys Ala Phe Lys Ala Asp 
            20                  25                  30          


Asp Gly Pro Cys Lys Ala Ile Met Lys Arg Phe Phe Phe Asn Ile Phe 
        35                  40                  45              


Thr Arg Gln Cys Glu Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gln 
    50                  55                  60                  


Asn Arg Phe Glu Ser Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp 
65                  70                  75                  80  


Asn Ala Asn Arg Ile Ile Lys Thr Thr Leu Gln Gln Glu Lys Pro Asp 
                85                  90                  95      


Phe Cys Phe Leu Glu Glu Asp Pro Gly Ile Cys Arg Gly Tyr Ile Thr 
            100                 105                 110         


Arg Tyr Phe Tyr Asn Asn Gln Thr Lys Gln Cys Glu Arg Phe Lys Tyr 
        115                 120                 125             


Gly Gly Cys Leu Gly Asn Met Asn Asn Phe Glu Thr Leu Glu Glu Cys 
    130                 135                 140                 


Lys Asn Ile Cys Glu Asp Gly Pro Asn Gly Phe Gln Val Asp Asn Tyr 
145                 150                 155                 160 


Gly Thr Gln Leu Asn Ala Val Asn Asn Ser Leu Thr Pro Gln Ser Thr 
                165                 170                 175     


Lys Val Pro Ser Leu Phe Glu Phe His Gly Pro Ser Trp Cys Leu Thr 
            180                 185                 190         


Pro Ala Asp Arg Gly Leu Cys Arg Ala Asn Glu Asn Arg Phe Tyr Tyr 
        195                 200                 205             


Asn Ser Val Ile Gly Lys Cys Arg Pro Phe Lys Tyr Ser Gly Cys Gly 
    210                 215                 220                 


Gly Asn Glu Asn Asn Phe Thr Ser Lys Gln Glu Cys Leu Arg Ala Cys 
225                 230                 235                 240 


Lys Lys Gly Phe Ile Gln Arg Ile Ser Lys Gly Gly Leu Ile Lys Thr 
                245                 250                 255     


Lys Arg Lys Arg Lys Lys Gln Arg Val Lys Ile Ala Tyr Glu Glu Ile 
            260                 265                 270         


Phe Val Lys Asn Met 
        275         


<210>  3
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Lys Arg Lys Arg Lys Lys Gln Arg Val Lys Ile Ala Tyr Glu Glu 
1               5                   10                  15      


Ile Phe Val Lys Asn Met 
            20          


<210>  4
<211>  27
<212>  PRT
<213>  homo sapiens

<400>  4

Gly Phe Ile Gln Arg Ile Ser Lys Gly Gly Leu Ile Lys Thr Lys Arg 
1               5                   10                  15      


Lys Arg Lys Lys Gln Arg Val Lys Ile Ala Tyr 
            20                  25          


<210>  5
<211>  35
<212>  PRT
<213>  HOMO SAPIENS

<400>  5

Gly Phe Ile Gln Arg Ile Ser Lys Gly Gly Leu Ile Lys Thr Lys Arg 
1               5                   10                  15      


Lys Arg Lys Lys Gln Arg Val Lys Ile Ala Tyr Glu Glu Ile Phe Val 
            20                  25                  30          


Lys Asn Met 
        35  


<210>  6
<211>  37
<212>  PRT
<213>  artificial

<220>
<223>  Control peptide

<400>  6

Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210>  7
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Scrambled peptide control

<400>  7

Asn Phe Gln Arg Lys Glu Lys Arg Glu Val Ile Tyr Lys Val Lys Thr 
1               5                   10                  15      


Lys Ile Lys Ala Met Arg 
            20          


<210>  8
<211>  14
<212>  PRT
<213>  HOMO SAPIENS

<400>  8

Thr Lys Arg Lys Arg Lys Lys Gln Arg Val Lys Ile Ala Tyr 
1               5                   10                  


<210>  9
<211>  187
<212>  PRT
<213>  homo sapiens

<400>  9

Gln Gln Glu Lys Pro Asp Phe Cys Phe Leu Glu Glu Asp Pro Gly Ile 
1               5                   10                  15      


Cys Arg Gly Tyr Ile Thr Arg Tyr Phe Tyr Asn Asn Gln Thr Lys Gln 
            20                  25                  30          


Cys Glu Arg Phe Lys Tyr Gly Gly Cys Leu Gly Asn Met Asn Asn Phe 
        35                  40                  45              


Glu Thr Leu Glu Glu Cys Lys Asn Ile Cys Glu Asp Gly Pro Asn Gly 
    50                  55                  60                  


Phe Gln Val Asp Asn Tyr Gly Thr Gln Leu Asn Ala Val Asn Asn Ser 
65                  70                  75                  80  


Leu Thr Pro Gln Ser Thr Lys Val Pro Ser Leu Phe Glu Phe His Gly 
                85                  90                  95      


Pro Ser Trp Cys Leu Thr Pro Ala Asp Arg Gly Leu Cys Arg Ala Asn 
            100                 105                 110         


Glu Asn Arg Phe Tyr Tyr Asn Ser Val Ile Gly Lys Cys Arg Pro Phe 
        115                 120                 125             


Lys Tyr Ser Gly Cys Gly Gly Asn Glu Asn Asn Phe Thr Ser Lys Gln 
    130                 135                 140                 


Glu Cys Leu Arg Ala Cys Lys Lys Gly Phe Ile Gln Arg Ile Ser Lys 
145                 150                 155                 160 


Gly Gly Leu Ile Lys Thr Lys Arg Lys Arg Lys Lys Gln Arg Val Lys 
                165                 170                 175     


Ile Ala Tyr Glu Glu Ile Phe Val Lys Asn Met 
            180                 185         


<210>  10
<211>  23
<212>  PRT
<213>  homo sapiens

<400>  10

Lys Thr Lys Arg Lys Arg Lys Lys Gln Arg Val Lys Ile Ala Tyr Glu 
1               5                   10                  15      


Glu Ile Phe Val Lys Asn Met 
            20              


<210>  11
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal leader sequence

<400>  11

Ala Asp Ser Glu Glu Asp Glu Glu His Thr Ile Ile Thr Asp Thr 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  N-terminal leader sequence


<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Gly Thr Gln Leu Asn Ala Val Asn Asn Ser Leu Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal T-helper sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(15)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Asn Xaa Val Asn Xaa Xaa Leu Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  C-terminal T-helper sequence


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Glu Phe His Gly Pro Ser Trp Xaa Leu Thr Pro Ala Asp Arg Gly 
1               5                   10                  15  


