
                                SEQUENCE LISTING

<110> Zhou, Yun-Ping
      Howard, Andrew
      Thornberry, Nancy

<120> PANCREATIC BETA-CELL MASS BIOMARKER
  

<130> MRL-BIO-22432-PCT

<150> 61/124,941          
<151> 2008-04-21  

<160> 6

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1009
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (223)...(894)
<223> Encodes CFC1

<400> 1
cactgcgccc ccgaccctag ctcagggact gcagaactca agataccatc ccgtttctcc 60
tggctgagga agggaaggga acatccacat cttctgtact cgtccattct gtgtccccgg 120
ggcctggagt aaagacacct tcaaatgcag agactcttca gattcagctt tcctggaaac 180
tgatcttcaa tgcactaaga gaaggagact ctcaaaccaa aa atg acc tgg agg    234
                                               Met Thr Trp Arg
                                                1
 
cac cat gtc agg ctt ctg ttt acg gtc agt ttg gca tta cag atc atc   282
His His Val Arg Leu Leu Phe Thr Val Ser Leu Ala Leu Gln Ile Ile
 5                   10                  15                  20
 
aat ttg gga aac agc tat caa aga gag aaa cat aac ggc ggt aga gag   330
Asn Leu Gly Asn Ser Tyr Gln Arg Glu Lys His Asn Gly Gly Arg Glu
                 25                  30                  35
 
gaa gtc acc aag gtt gcc act cag aag cac cga cag tca ccg ctc aac   378
Glu Val Thr Lys Val Ala Thr Gln Lys His Arg Gln Ser Pro Leu Asn
             40                  45                  50
 
tgg acc tcc agt cat ttc gga gag gtg act ggg agc gcc gag ggc tgg   426
Trp Thr Ser Ser His Phe Gly Glu Val Thr Gly Ser Ala Glu Gly Trp
         55                  60                  65
 
ggg ccg gag gag ccg ctc ccc tac tcc cgg gct ttc gga gag ggt gcg   474
Gly Pro Glu Glu Pro Leu Pro Tyr Ser Arg Ala Phe Gly Glu Gly Ala
     70                  75                  80
 
tcc gcg cgg ccg cgc tgc tgc agg aac ggc ggt acc tgc gtg ctg ggc   522
Ser Ala Arg Pro Arg Cys Cys Arg Asn Gly Gly Thr Cys Val Leu Gly
 85                  90                  95                 100
 
agc ttc tgc gtg tgc ccg gcc cac ttc acc ggc cgc tac tgc gag cat   570
Ser Phe Cys Val Cys Pro Ala His Phe Thr Gly Arg Tyr Cys Glu His
                105                 110                 115
 
gac cag agg cgc agt gaa tgc ggc gcc ctg gag cac gga gcc tgg acc   618
Asp Gln Arg Arg Ser Glu Cys Gly Ala Leu Glu His Gly Ala Trp Thr
            120                 125                 130
 
ctc cgc gcc tgc cac ctc tgc agg tgc atc ttc ggg gcc ctg cac tgc   666
Leu Arg Ala Cys His Leu Cys Arg Cys Ile Phe Gly Ala Leu His Cys
        135                 140                 145
 
ctc ccc ctc cag acg cct gac cgc tgt gac ccg aaa gac ttc ctg gcc   714
Leu Pro Leu Gln Thr Pro Asp Arg Cys Asp Pro Lys Asp Phe Leu Ala
    150                 155                 160
 
tcc cac gct cac ggg ccg agc gcc ggg ggc gcg ccc agc ctg cta ctc   762
Ser His Ala His Gly Pro Ser Ala Gly Gly Ala Pro Ser Leu Leu Leu
165                 170                 175                 180
 
ttg ctg ccc tgc gca ctc ctg cac cgc ctc ctg cgc ccg gat gcg ccc   810
Leu Leu Pro Cys Ala Leu Leu His Arg Leu Leu Arg Pro Asp Ala Pro
                185                 190                 195
 
gcg cac cct cgg tcc ctg gtc cct tcc gtc ctc cag cgg gag cgg cgc   858
Ala His Pro Arg Ser Leu Val Pro Ser Val Leu Gln Arg Glu Arg Arg
            200                 205                 210
 
ccc tgc gga agg ccg gga ctt ggg cat cgc ctt taa ttttctatgt        904
Pro Cys Gly Arg Pro Gly Leu Gly His Arg Leu  *
        215                 220
 
tgtaaataat agatgtgttt agtttaccgt aagctgaagc actgggtgaa tatttttatt 964
gggtaataaa tattttcatg aaagcgcctt tggctccaga tcctt                 1009

<210> 2
<211> 223
<212> PRT
<213> Homo sapiens

<400> 2
Met Thr Trp Arg His His Val Arg Leu Leu Phe Thr Val Ser Leu Ala
 1               5                  10                  15      
Leu Gln Ile Ile Asn Leu Gly Asn Ser Tyr Gln Arg Glu Lys His Asn
            20                  25                  30          
Gly Gly Arg Glu Glu Val Thr Lys Val Ala Thr Gln Lys His Arg Gln
        35                  40                  45              
Ser Pro Leu Asn Trp Thr Ser Ser His Phe Gly Glu Val Thr Gly Ser
    50                  55                  60                  
Ala Glu Gly Trp Gly Pro Glu Glu Pro Leu Pro Tyr Ser Arg Ala Phe
65                  70                  75                  80  
Gly Glu Gly Ala Ser Ala Arg Pro Arg Cys Cys Arg Asn Gly Gly Thr
                85                  90                  95      
Cys Val Leu Gly Ser Phe Cys Val Cys Pro Ala His Phe Thr Gly Arg
            100                 105                 110         
Tyr Cys Glu His Asp Gln Arg Arg Ser Glu Cys Gly Ala Leu Glu His
        115                 120                 125             
Gly Ala Trp Thr Leu Arg Ala Cys His Leu Cys Arg Cys Ile Phe Gly
    130                 135                 140                 
Ala Leu His Cys Leu Pro Leu Gln Thr Pro Asp Arg Cys Asp Pro Lys
145                 150                 155                 160 
Asp Phe Leu Ala Ser His Ala His Gly Pro Ser Ala Gly Gly Ala Pro
                165                 170                 175     
Ser Leu Leu Leu Leu Leu Pro Cys Ala Leu Leu His Arg Leu Leu Arg
            180                 185                 190         
Pro Asp Ala Pro Ala His Pro Arg Ser Leu Val Pro Ser Val Leu Gln
        195                 200                 205             
Arg Glu Arg Arg Pro Cys Gly Arg Pro Gly Leu Gly His Arg Leu
    210                 215                 220             


<210> 3
<211> 1038
<212> DNA
<213> Mus musculus

<220> 
<221> CDS            
<222> (256)...(864)
<223> Encodes CFC1

<400> 3
caggactgta tagggtcagc acttccagcc tggtggttca gagctcctga cctgagaggg 60
cttcaacacc tggactccag gatcttcctt taaccctgct gtctctggtc caggcagagg 120
gcagagacat cttcatcttg caagactgtg catcctgtaa cctgctatag tgattccaag 180
acctggagta aagggtgcct ccggggctag gatatttgag tttcaacttc tgtggtcatc 240
gatccccaag cacag atg aga gcg aac tca cca acc cag ggt atc agt ttg  291
                 Met Arg Ala Asn Ser Pro Thr Gln Gly Ile Ser Leu
                  1               5                   10
 
aaa atg cat caa gcc agg cct ctg ttt ttg gtg act gtc gcg ctg cag   339
Lys Met His Gln Ala Arg Pro Leu Phe Leu Val Thr Val Ala Leu Gln
         15                  20                  25
 
ctc atc ggt ctg gga tac agt tat cag agc gaa gga gat ggt gcc aga   387
Leu Ile Gly Leu Gly Tyr Ser Tyr Gln Ser Glu Gly Asp Gly Ala Arg
     30                  35                  40
 
gaa gtc agc aat atc ctc tct cca gtg atc ccc ggg acg aca ctg gac   435
Glu Val Ser Asn Ile Leu Ser Pro Val Ile Pro Gly Thr Thr Leu Asp
 45                  50                  55                  60
 
aga act ctg agt aat tcc agc aga aag aat gac att ccg gag ggg gcg   483
Arg Thr Leu Ser Asn Ser Ser Arg Lys Asn Asp Ile Pro Glu Gly Ala
                 65                  70                  75
 
cgc cta tgg gat tcc ctt cct gac tcc agc act ttg gga gag agt gca   531
Arg Leu Trp Asp Ser Leu Pro Asp Ser Ser Thr Leu Gly Glu Ser Ala
             80                  85                  90
 
gtc cct gta tcc cgc tgt tgc cac aat ggc ggc acc tgt gtt ctg ggc   579
Val Pro Val Ser Arg Cys Cys His Asn Gly Gly Thr Cys Val Leu Gly
         95                 100                 105
 
agt ttc tgc gtg tgc cct gcc tat ttc act ggt cgc tat tgc gag cac   627
Ser Phe Cys Val Cys Pro Ala Tyr Phe Thr Gly Arg Tyr Cys Glu His
    110                 115                 120
 
gac cag agg cgc aga gac tgt ggt gcc cta ggg cat gga gct tgg acc   675
Asp Gln Arg Arg Arg Asp Cys Gly Ala Leu Gly His Gly Ala Trp Thr
125                 130                 135                 140
 
ctg cac agc tgc cgc cta tgc agg tgc atc ttc tca gcc ctg tac tgc   723
Leu His Ser Cys Arg Leu Cys Arg Cys Ile Phe Ser Ala Leu Tyr Cys
                145                 150                 155
 
ctc cca cac caa acg ttc agc cac tgt gac ctg aaa agc ttc ctt tct   771
Leu Pro His Gln Thr Phe Ser His Cys Asp Leu Lys Ser Phe Leu Ser
            160                 165                 170
 
tca ggc gcc aga gga tca aga gaa tgc agc atc cca agc ctc ctc ctg   819
Ser Gly Ala Arg Gly Ser Arg Glu Cys Ser Ile Pro Ser Leu Leu Leu
        175                 180                 185
 
ctg gtg ctc tgc ctc ctc ctg cag ggt gtg gct ggt aag ggc tga       864
Leu Val Leu Cys Leu Leu Leu Gln Gly Val Ala Gly Lys Gly  *
    190                 195                 200
 
ggctcctaag tgcgatgata gactctcctc ctgagctgtc acccttgatt acaccacagt 924
gtgccagcaa gaaagctggg tggtgggcat ctgacttggt gttgtgtcct gtaaataaca 984
gattcactgg aatatgctgg attctcatgc tgtacaataa agaggcttaa tggt       1038

<210> 4
<211> 202
<212> PRT
<213> Mus musculus

<400> 4
Met Arg Ala Asn Ser Pro Thr Gln Gly Ile Ser Leu Lys Met His Gln
 1               5                  10                  15      
Ala Arg Pro Leu Phe Leu Val Thr Val Ala Leu Gln Leu Ile Gly Leu
            20                  25                  30          
Gly Tyr Ser Tyr Gln Ser Glu Gly Asp Gly Ala Arg Glu Val Ser Asn
        35                  40                  45              
Ile Leu Ser Pro Val Ile Pro Gly Thr Thr Leu Asp Arg Thr Leu Ser
    50                  55                  60                  
Asn Ser Ser Arg Lys Asn Asp Ile Pro Glu Gly Ala Arg Leu Trp Asp
65                  70                  75                  80  
Ser Leu Pro Asp Ser Ser Thr Leu Gly Glu Ser Ala Val Pro Val Ser
                85                  90                  95      
Arg Cys Cys His Asn Gly Gly Thr Cys Val Leu Gly Ser Phe Cys Val
            100                 105                 110         
Cys Pro Ala Tyr Phe Thr Gly Arg Tyr Cys Glu His Asp Gln Arg Arg
        115                 120                 125             
Arg Asp Cys Gly Ala Leu Gly His Gly Ala Trp Thr Leu His Ser Cys
    130                 135                 140                 
Arg Leu Cys Arg Cys Ile Phe Ser Ala Leu Tyr Cys Leu Pro His Gln
145                 150                 155                 160 
Thr Phe Ser His Cys Asp Leu Lys Ser Phe Leu Ser Ser Gly Ala Arg
                165                 170                 175     
Gly Ser Arg Glu Cys Ser Ile Pro Ser Leu Leu Leu Leu Val Leu Cys
            180                 185                 190         
Leu Leu Leu Gln Gly Val Ala Gly Lys Gly
        195                 200         


<210> 5
<211> 873
<212> DNA
<213> Rattus norvegicus

<220> 
<221> CDS            
<222> (1)...(675)
<223> Encodes CFC1

<400> 5
atg cag atc ccg aag gct agc tat gcg cgc atc cgg aac cct agc cca   48
Met Gln Ile Pro Lys Ala Ser Tyr Ala Arg Ile Arg Asn Pro Ser Pro
 1               5                   10                  15
 
gga aga cct tgg cta acg tcc cca gtg atg acg tat gtg aaa aag caa   96
Gly Arg Pro Trp Leu Thr Ser Pro Val Met Thr Tyr Val Lys Lys Gln
             20                  25                  30
 
acc cta tgg gca cgt tgc ccg tcc acc cag agt ctc ttc aca tca gct   144
Thr Leu Trp Ala Arg Cys Pro Ser Thr Gln Ser Leu Phe Thr Ser Ala
         35                  40                  45
 
gca cag ctg ctt atc cat ttg tgg agc ggg cag ttg aga gaa gga gat   192
Ala Gln Leu Leu Ile His Leu Trp Ser Gly Gln Leu Arg Glu Gly Asp
     50                  55                  60
 
ggt gcc aga gaa att agc tat ctc ctg tct cca aag ctc cca ggg acg   240
Gly Ala Arg Glu Ile Ser Tyr Leu Leu Ser Pro Lys Leu Pro Gly Thr
 65                  70                  75                  80
 
aca ctg gat gga acc ctg agt agt tcc agt aga aag aat gac agc cag   288
Thr Leu Asp Gly Thr Leu Ser Ser Ser Ser Arg Lys Asn Asp Ser Gln
                 85                  90                  95
 
gag gga gcg cac ccg tcg gag gcc ctt tct ggt tcc aac act ttg gag   336
Glu Gly Ala His Pro Ser Glu Ala Leu Ser Gly Ser Asn Thr Leu Glu
            100                 105                 110
 
gag agt gcg gtc cct gga tcc cgc tgt tgc cac aat gga ggc acc tgc   384
Glu Ser Ala Val Pro Gly Ser Arg Cys Cys His Asn Gly Gly Thr Cys
        115                 120                 125
 
gtt ctg ggc agt ttc tgc gtg tgc ccc gcg cac ttc aca ggt cgc tac   432
Val Leu Gly Ser Phe Cys Val Cys Pro Ala His Phe Thr Gly Arg Tyr
    130                 135                 140
 
tgc gag cac gac cag aga cac aga gac tgt ggc gca ctg ggg cac gga   480
Cys Glu His Asp Gln Arg His Arg Asp Cys Gly Ala Leu Gly His Gly
145                 150                 155                 160
 
gct tgg acc ctg cac agc tgc cgc cta tgc agg tgc atc ttc tca gcc   528
Ala Trp Thr Leu His Ser Cys Arg Leu Cys Arg Cys Ile Phe Ser Ala
                165                 170                 175
 
ctt tac tgc ctc cca cgc caa aca ttc agc cac tgt gac ctg aaa agc   576
Leu Tyr Cys Leu Pro Arg Gln Thr Phe Ser His Cys Asp Leu Lys Ser
            180                 185                 190
 
ttc ctc tct tca ggc gcc aga gga tca agg gca tgc agc atc ccg aga   624
Phe Leu Ser Ser Gly Ala Arg Gly Ser Arg Ala Cys Ser Ile Pro Arg
        195                 200                 205
 
ctc ctc ctg ctg gtg ctc tgc ctc ctc ctg cag gtt gtg tgt ggc tgg   672
Leu Leu Leu Leu Val Leu Cys Leu Leu Leu Gln Val Val Cys Gly Trp
    210                 215                 220
 
taa gggctgaggc tctgaactgc cctgacagaa tctcctcctg agcctgcaag        725
 *

 
gtgtcaccct tgactaccca tggcaccaca gcacgcctgc aggaaagctg ggtggtgggt 785
atctgcttca gtgttgaatg ctgtaaatga ccgaatggct gaaatatgct ggatcctcgt 845
gctgtgcaat aaagacgttc aacagcga                                    873

<210> 6
<211> 224
<212> PRT
<213> Rattus norvegicus

<400> 6
Met Gln Ile Pro Lys Ala Ser Tyr Ala Arg Ile Arg Asn Pro Ser Pro
 1               5                  10                  15      
Gly Arg Pro Trp Leu Thr Ser Pro Val Met Thr Tyr Val Lys Lys Gln
            20                  25                  30          
Thr Leu Trp Ala Arg Cys Pro Ser Thr Gln Ser Leu Phe Thr Ser Ala
        35                  40                  45              
Ala Gln Leu Leu Ile His Leu Trp Ser Gly Gln Leu Arg Glu Gly Asp
    50                  55                  60                  
Gly Ala Arg Glu Ile Ser Tyr Leu Leu Ser Pro Lys Leu Pro Gly Thr
65                  70                  75                  80  
Thr Leu Asp Gly Thr Leu Ser Ser Ser Ser Arg Lys Asn Asp Ser Gln
                85                  90                  95      
Glu Gly Ala His Pro Ser Glu Ala Leu Ser Gly Ser Asn Thr Leu Glu
            100                 105                 110         
Glu Ser Ala Val Pro Gly Ser Arg Cys Cys His Asn Gly Gly Thr Cys
        115                 120                 125             
Val Leu Gly Ser Phe Cys Val Cys Pro Ala His Phe Thr Gly Arg Tyr
    130                 135                 140                 
Cys Glu His Asp Gln Arg His Arg Asp Cys Gly Ala Leu Gly His Gly
145                 150                 155                 160 
Ala Trp Thr Leu His Ser Cys Arg Leu Cys Arg Cys Ile Phe Ser Ala
                165                 170                 175     
Leu Tyr Cys Leu Pro Arg Gln Thr Phe Ser His Cys Asp Leu Lys Ser
            180                 185                 190         
Phe Leu Ser Ser Gly Ala Arg Gly Ser Arg Ala Cys Ser Ile Pro Arg
        195                 200                 205             
Leu Leu Leu Leu Val Leu Cys Leu Leu Leu Gln Val Val Cys Gly Trp
    210                 215                 220                 

