                         SEQUENCE LISTING

<110>  Merck & Co., Inc.
       Zhang, Z.
       Sun, H.
       Dai, H.
       Schelter, J.
       Burchard, J.
       Dai, X.
       Carleton, M.
       Cleary, M.
       Linsley, P.
       Grandori, C.
 
<120>  METHODS OF USING MIR210 AS A BIOMARKER FOR HYPOXIA AND AS A 
       THERAPEUTIC AGENT FOR TREATING CANCER

<130>  ROSA-1-33067

<150>  US 61/047,690
<151>  2008-04-24

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  1
cugugcgugu gacagcggcu g                                                 21


<210>  2
<211>  1965
<212>  DNA
<213>  Homo sapiens

<400>  2
gagagggtgc cagcggccgc agctgaagtt gggccgagag ccggcgacgg ccccgcgccg       60

gggtcgcagg cctgcaggag ttgagggctg cacctgctcg ctggagaggg agaggcagat      120

ttagtggacg cctggcatgg actcggactg gcctttggaa gctccctgcc ctgacggggt      180

tgcctgtcac cactgcgaag tgaggcttgg caggacctgc acctgagaaa ggccgtgtgt      240

ggtcttgggg tccacacctg cagagctaac ttactgccag acggcgactt actgtgggcc      300

accctcagtg aaccggggtg tcctcagctg gccctacaga gcacttctgt gctggggatg      360

agtaggaatt ctgggcgagg agggtcccag cgccgcccct cgatacagcc tggctctgcc      420

ctctgcccgt acttatacca ggtgggatcc ctgccctgca ttgcctgggg attggctggg      480

cttgggcccg ccctgctgtg gaactggatg ttttcaggga gcccagcctt tcctcatgtc      540

aacacagttc acaatatagt tttcaaagta cagtttaaaa ctcaaaagta aacttttcag      600

caactcaaag gtttgctgag tgatctgaag cactctggcc actttttggg gccatgggat      660

ttggttcacc tgaaacagcc agtgagaggc cgggtgtggt ggctcacacc cgtaatccca      720

acacttcagg aggcagacgc gggtgatcgc tcacttgaga tcaggagttc aagaccagcc      780

tgggcaacat ggtgaaacct cgtctctact aaaaatacaa aaattagcta ggcatggtgg      840

tgggcacctg taatcccagc tacttggaag gctgaggcaa gagaatcgct tgaacctggg      900

aggtggaggt tgcagcgaga cgagattacg ccgctgcact ccagcctggg tgacgagaga      960

ctctgcctca aaaaaataaa aaaatgaaac agccagtgag gaggaaggct ccccgccttc     1020

cccccgccgg aacatagcca tagctgctgc tgggacaccc tcttggtggg gaagaagact     1080

ggttagcttc atcagagcca gcagcagcag accagggacg ggcacctagg cagtggcctc     1140

agagtgaaca ggagttcctc agaaacacac acagggacgg cgtggcgcat gctctgccag     1200

ctccatgcct ccttcccatt gtggggctgg gctacgtagg gcagagctca tgacctccgg     1260

gaggacatgg gggtgggctc tggatggcac ctggcattgc cccctgctgg cctatgtgac     1320

ggtgtggagg gctggtcaca gaggtacgac catcccttca gaatgtgggt cggggctgtg     1380

gatggaggag taggcccctc atatcccagg cctgctgccc aggcacaacc cacttggcct     1440

atgcattcca ggctccatcc catgtgactc tgggcttagc cccttctggg gccacaggtc     1500

aggcaggtcc aggccccaag gacctcccag tgacaggcga ctgtgagctg ggcagacagg     1560

agtgaagtca ggtgggggtt ctggcttgct gacaccagcg tttggagcct cctgctgctg     1620

cctggcttcc ctgcattccc tgttccctgc ctcaggcaag aaataaccaa gccgagttgc     1680

ctctgcacag cagtgagctc ctggtggccc tggcttctgg ggagccctgt ggatggcttc     1740

cttgcccaag tcaaggcctt cttgttccct ttgtgtgctc cagagaaagg gggcagcacc     1800

agatccagat ccagggccaa ccaacagaaa gctgagtcca tcccaaactc gcccattctc     1860

agagcacaaa gaccccatga tctagggcaa acttgtccaa ctgttggccc atggaacagc     1920

tttgaatgca gcccaacaca aatctataaa ttttcttaaa cattg                     1965


<210>  3
<211>  110
<212>  RNA
<213>  Homo sapiens

<400>  3
acccggcagu gccuccaggc gcagggcagc cccugcccac cgcacacugc gcugccccag       60

acccacugug cgugugacag cggcugaucu gugccugggc agcgcgaccc                 110


<210>  4
<211>  12
<212>  RNA
<213>  Homo sapiens

<400>  4
cugugcgugu ga                                                           12


<210>  5
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
cugucggugu gacagcggcu g                                                 21


<210>  6
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Nucleotide at postion 20 and 21 is a deoxythymidine

<400>  6
guccuuaaac cgguugaaun n                                                 21


<210>  7
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Nucleotide at position 20 and 21 is deoxythymidine

<400>  7
gcaacuugag gaaguaccan n                                                 21


<210>  8
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Nucleotide at position 20 and 21 is deoxythymidine

<400>  8
ccuaauaguc ccagugaaun n                                                 21


<210>  9
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Nucleotide at position 20 and 21 is deoxythymidine

<400>  9
ggcucaagga gaucguuuan n                                                 21


<210>  10
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Nucleotide at position 20 and 21 is deoxythymidine

<400>  10
gaauggacuu ggcucuguan n                                                 21


<210>  11
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Nucleotide at position 20 and 21 is deoxythymidine

<400>  11
gccacagucu gaaugguuun n                                                 21


<210>  12
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Nucleotide at position 20 and 21 is deoxythymidine

<400>  12
cgggccaggu gaaagucuan n                                                 21


<210>  13
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Nucleotide at position 20 and 21 is deoxythymidine

<400>  13
gcgacagcug gaguaugaan n                                                 21


<210>  14
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Nucleotide at position 20 and 21 is deoxythymidine

<400>  14
gcuucagugc caugacaaan n                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
cguccaaucu gagcgugcut t                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
gcuggcacgu gagaagauut t                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
gguacaucca gucccugaat t                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
gcuuguaccu gcaggaucut t                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
cgauguuguu ucuguggaat t                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
cgagaacagu ugaaacacat t                                                 21


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
aggagccttg acggtttgac                                                   20


<210>  22
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
gaggaccagg gtgacagtg                                                    19


<210>  23
<211>  2377
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (525)..(1889)

<400>  23
acccccgagc tgtgctgctc gcggccgcca ccgccgggcc ccggccgtcc ctggctcccc       60

tcctgcctcg agaagggcag ggcttctcag aggcttggcg ggaaaaagaa cggagggagg      120

gatcgcgctg agtataaaag ccggttttcg gggctttatc taactcgctg tagtaattcc      180

agcgagaggc agagggagcg agcgggcggc cggctagggt ggaagagccg ggcgagcaga      240

gctgcgctgc gggcgtcctg ggaagggaga tccggagcga atagggggct tcgcctctgg      300

cccagccctc ccgctgatcc cccagccagc ggtccgcaac ccttgccgca tccacgaaac      360

tttgcccata gcagcgggcg ggcactttgc actggaactt acaacacccg agcaaggacg      420

cgactctccc gacgcgggga ggctattctg cccatttggg gacacttccc cgccgctgcc      480

aggacccgct tctctgaaag gctctccttg cagctgctta gacg ctg gat ttt ttt       536
                                                 Leu Asp Phe Phe          
                                                 1                        

cgg gta gtg gaa aac cag cag cct ccc gcg acg atg ccc ctc aac gtt        584
Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met Pro Leu Asn Val           
5                   10                  15                  20            

agc ttc acc aac agg aac tat gac ctc gac tac gac tcg gtg cag ccg        632
Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp Ser Val Gln Pro           
                25                  30                  35                

tat ttc tac tgc gac gag gag gag aac ttc tac cag cag cag cag cag        680
Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln Gln Gln Gln Gln           
            40                  45                  50                    

agc gag ctg cag ccc ccg gcg ccc agc gag gat atc tgg aag aaa ttc        728
Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile Trp Lys Lys Phe           
        55                  60                  65                        

gag ctg ctg ccc acc ccg ccc ctg tcc cct agc cgc cgc tcc ggg ctc        776
Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg Arg Ser Gly Leu           
    70                  75                  80                            

tgc tcg ccc tcc tac gtt gcg gtc aca ccc ttc tcc ctt cgg gga gac        824
Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser Leu Arg Gly Asp           
85                  90                  95                  100           

aac gac ggc ggt ggc ggg agc ttc tcc acg gcc gac cag ctg gag atg        872
Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp Gln Leu Glu Met           
                105                 110                 115               

gtg acc gag ctg ctg gga gga gac atg gtg aac cag agt ttc atc tgc        920
Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln Ser Phe Ile Cys           
            120                 125                 130                   

gac ccg gac gac gag acc ttc atc aaa aac atc atc atc cag gac tgt        968
Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile Ile Gln Asp Cys           
        135                 140                 145                       

atg tgg agc ggc ttc tcg gcc gcc gcc aag ctc gtc tca gag aag ctg       1016
Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val Ser Glu Lys Leu           
    150                 155                 160                           

gcc tcc tac cag gct gcg cgc aaa gac agc ggc agc ccg aac ccc gcc       1064
Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser Pro Asn Pro Ala           
165                 170                 175                 180           

cgc ggc cac agc gtc tgc tcc acc tcc agc ttg tac ctg cag gat ctg       1112
Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr Leu Gln Asp Leu           
                185                 190                 195               

agc gcc gcc gcc tca gag tgc atc gac ccc tcg gtg gtc ttc ccc tac       1160
Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val Val Phe Pro Tyr           
            200                 205                 210                   

cct ctc aac gac agc agc tcg ccc aag tcc tgc gcc tcg caa gac tcc       1208
Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala Ser Gln Asp Ser           
        215                 220                 225                       

agc gcc ttc tct ccg tcc tcg gat tct ctg ctc tcc tcg acg gag tcc       1256
Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser Ser Thr Glu Ser           
    230                 235                 240                           

tcc ccg cag ggc agc ccc gag ccc ctg gtg ctc cat gag gag aca ccg       1304
Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His Glu Glu Thr Pro           
245                 250                 255                 260           

ccc acc acc agc agc gac tct gag gag gaa caa gaa gat gag gaa gaa       1352
Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu Asp Glu Glu Glu           
                265                 270                 275               

atc gat gtt gtt tct gtg gaa aag agg cag gct cct ggc aaa agg tca       1400
Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro Gly Lys Arg Ser           
            280                 285                 290                   

gag tct gga tca cct tct gct gga ggc cac agc aaa cct cct cac agc       1448
Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys Pro Pro His Ser           
        295                 300                 305                       

cca ctg gtc ctc aag agg tgc cac gtc tcc aca cat cag cac aac tac       1496
Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His Gln His Asn Tyr           
    310                 315                 320                           

gca gcg cct ccc tcc act cgg aag gac tat cct gct gcc aag agg gtc       1544
Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala Ala Lys Arg Val           
325                 330                 335                 340           

aag ttg gac agt gtc aga gtc ctg aga cag atc agc aac aac cga aaa       1592
Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser Asn Asn Arg Lys           
                345                 350                 355               

tgc acc agc ccc agg tcc tcg gac acc gag gag aat gtc aag agg cga       1640
Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn Val Lys Arg Arg           
            360                 365                 370                   

aca cac aac gtc ttg gag cgc cag agg agg aac gag cta aaa cgg agc       1688
Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser           
        375                 380                 385                       

ttt ttt gcc ctg cgt gac cag atc ccg gag ttg gaa aac aat gaa aag       1736
Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu Asn Asn Glu Lys           
    390                 395                 400                           

gcc ccc aag gta gtt atc ctt aaa aaa gcc aca gca tac atc ctg tcc       1784
Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala Tyr Ile Leu Ser           
405                 410                 415                 420           

gtc caa gca gag gag caa aag ctc att tct gaa gag gac ttg ttg cgg       1832
Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Arg           
                425                 430                 435               

aaa cga cga gaa cag ttg aaa cac aaa ctt gaa cag cta cgg aac tct       1880
Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln Leu Arg Asn Ser           
            440                 445                 450                   

tgt gcg taa ggaaaagtaa ggaaaacgat tccttctaac agaaatgtcc               1929
Cys Ala                                                                   
                                                                          

tgagcaatca cctatgaact tgtttcaaat gcatgatcaa atgcaacctc acaaccttgg     1989

ctgagtcttg agactgaaag atttagccat aatgtaaact gcctcaaatt ggactttggg     2049

cataaaagaa cttttttatg cttaccatct tttttttttc tttaacagat ttgtatttaa     2109

gaattgtttt taaaaaattt taagatttac acaatgtttc tctgtaaata ttgccattaa     2169

atgtaaataa ctttaataaa acgtttatag cagttacaca gaatttcaat cctagtatat     2229

agtacctagt attataggta ctataaaccc taattttttt tatttaagta cattttgctt     2289

tttaaagttg atttttttct attgttttta gaaaaaataa aataactggc aaatatatca     2349

ttgagccaaa aaaaaaaaaa aaaaaaaa                                        2377


<210>  24
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  24

Leu Asp Phe Phe Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 
                85                  90                  95      


Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 
                165                 170                 175     


Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 
    210                 215                 220                 


Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Cys Ala 
    450                 


<210>  25
<211>  2613
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (301)..(1695)

<400>  25
gtcatctgtc tggacgcgct gggtggatgc ggggggctcc tgggaactgt gttggagccg       60

agcaagcgct agccaggcgc aagcgcgcac agactgtagc catccgagga cacccccgcc      120

cccccggccc acccggagac acccgcgcag aatcgcctcc ggatcccctg cagtcggcgg      180

gagtgttgga ggtcggcgcc ggcccccgcc ttccgcgccc cccacgggaa ggaagcaccc      240

ccggtattaa aacgaacggg gcggaaagaa gccctcagtc gccggccggg aggcgagccg      300

atg ccg agc tgc tcc acg tcc acc atg ccg ggc atg atc tgc aag aac        348
Met Pro Ser Cys Ser Thr Ser Thr Met Pro Gly Met Ile Cys Lys Asn           
1               5                   10                  15                

cca gac ctc gag ttt gac tcg cta cag ccc tgc ttc tac ccg gac gaa        396
Pro Asp Leu Glu Phe Asp Ser Leu Gln Pro Cys Phe Tyr Pro Asp Glu           
            20                  25                  30                    

gat gac ttc tac ttc ggc ggc ccc gac tcg acc ccc ccg ggg gag gac        444
Asp Asp Phe Tyr Phe Gly Gly Pro Asp Ser Thr Pro Pro Gly Glu Asp           
        35                  40                  45                        

atc tgg aag aag ttt gag ctg ctg ccc acg ccc ccg ctg tcg ccc agc        492
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser           
    50                  55                  60                            

cgt ggc ttc gcg gag cac agc tcc gag ccc ccg agc tgg gtc acg gag        540
Arg Gly Phe Ala Glu His Ser Ser Glu Pro Pro Ser Trp Val Thr Glu           
65                  70                  75                  80            

atg ctg ctt gag aac gag ctg tgg ggc agc ccg gcc gag gag gac gcg        588
Met Leu Leu Glu Asn Glu Leu Trp Gly Ser Pro Ala Glu Glu Asp Ala           
                85                  90                  95                

ttc ggc ctg ggg gga ctg ggt ggc ctc acc ccc aac ccg gtc atc ctc        636
Phe Gly Leu Gly Gly Leu Gly Gly Leu Thr Pro Asn Pro Val Ile Leu           
            100                 105                 110                   

cag gac tgc atg tgg agc ggc ttc tcc gcc cgc gag aag ctg gag cgc        684
Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Arg Glu Lys Leu Glu Arg           
        115                 120                 125                       

gcc gtg agc gag aag ctg cag cac ggc cgc ggg ccg cca acc gcc ggt        732
Ala Val Ser Glu Lys Leu Gln His Gly Arg Gly Pro Pro Thr Ala Gly           
    130                 135                 140                           

tcc acc gcc cag tcc ccg gga gcc ggc gcc gcc agc cct gcg ggt cgc        780
Ser Thr Ala Gln Ser Pro Gly Ala Gly Ala Ala Ser Pro Ala Gly Arg           
145                 150                 155                 160           

ggg cac ggc ggg gct gcg gga gcc ggc cgc gcc ggg gcc gcc ctg ccc        828
Gly His Gly Gly Ala Ala Gly Ala Gly Arg Ala Gly Ala Ala Leu Pro           
                165                 170                 175               

gcc gag ctc gcc cac ccg gcc gcc gag tgc gtg gat ccc gcc gtg gtc        876
Ala Glu Leu Ala His Pro Ala Ala Glu Cys Val Asp Pro Ala Val Val           
            180                 185                 190                   

ttc ccc ttt ccc gtg aac aag cgc gag cca gcg ccc gtg ccc gca gcc        924
Phe Pro Phe Pro Val Asn Lys Arg Glu Pro Ala Pro Val Pro Ala Ala           
        195                 200                 205                       

ccg gcc agt gcc ccg gcg gcg ggc cct gcg gtc gcc tcg ggg gcg ggt        972
Pro Ala Ser Ala Pro Ala Ala Gly Pro Ala Val Ala Ser Gly Ala Gly           
    210                 215                 220                           

att gcc gcc cca gcc ggg gcc ccg ggg gtc gcc cct ccg cgc cca ggc       1020
Ile Ala Ala Pro Ala Gly Ala Pro Gly Val Ala Pro Pro Arg Pro Gly           
225                 230                 235                 240           

ggc cgc cag acc agc ggc ggc gac cac aag gcc ctc agt acc tcc gga       1068
Gly Arg Gln Thr Ser Gly Gly Asp His Lys Ala Leu Ser Thr Ser Gly           
                245                 250                 255               

gag gac acc ctg agc gat tca gat gat gaa gat gat gaa gag gaa gat       1116
Glu Asp Thr Leu Ser Asp Ser Asp Asp Glu Asp Asp Glu Glu Glu Asp           
            260                 265                 270                   

gaa gag gaa gaa atc gac gtg gtc act gtg gag aag cgg cgt tcc tcc       1164
Glu Glu Glu Glu Ile Asp Val Val Thr Val Glu Lys Arg Arg Ser Ser           
        275                 280                 285                       

tcc aac acc aag gct gtc acc aca ttc acc atc act gtg cgt ccc aag       1212
Ser Asn Thr Lys Ala Val Thr Thr Phe Thr Ile Thr Val Arg Pro Lys           
    290                 295                 300                           

aac gca gcc ctg ggt ccc ggg agg gct cag tcc agc gag ctg atc ctc       1260
Asn Ala Ala Leu Gly Pro Gly Arg Ala Gln Ser Ser Glu Leu Ile Leu           
305                 310                 315                 320           

aaa cga tgc ctt ccc atc cac cag cag cac aac tat gcc gcc ccc tct       1308
Lys Arg Cys Leu Pro Ile His Gln Gln His Asn Tyr Ala Ala Pro Ser           
                325                 330                 335               

ccc tac gtg gag agt gag gat gca ccc cca cag aag aag ata aag agc       1356
Pro Tyr Val Glu Ser Glu Asp Ala Pro Pro Gln Lys Lys Ile Lys Ser           
            340                 345                 350                   

gag gcg tcc cca cgt ccg ctc aag agt gtc atc ccc cca aag gct aag       1404
Glu Ala Ser Pro Arg Pro Leu Lys Ser Val Ile Pro Pro Lys Ala Lys           
        355                 360                 365                       

agc ttg agc ccc cga aac tct gac tcg gag gac agt gag cgt cgc aga       1452
Ser Leu Ser Pro Arg Asn Ser Asp Ser Glu Asp Ser Glu Arg Arg Arg           
    370                 375                 380                           

aac cac aac atc ctg gag cgc cag cgc cgc aac gac ctt cgg tcc agc       1500
Asn His Asn Ile Leu Glu Arg Gln Arg Arg Asn Asp Leu Arg Ser Ser           
385                 390                 395                 400           

ttt ctc acg ctc agg gac cac gtg ccg gag ttg gta aag aat gag aag       1548
Phe Leu Thr Leu Arg Asp His Val Pro Glu Leu Val Lys Asn Glu Lys           
                405                 410                 415               

gcc gcc aag gtg gtc att ttg aaa aag gcc act gag tat gtc cac tcc       1596
Ala Ala Lys Val Val Ile Leu Lys Lys Ala Thr Glu Tyr Val His Ser           
            420                 425                 430                   

ctc cag gcc gag gag cac cag ctt ttg ctg gaa aag gaa aaa ttg cag       1644
Leu Gln Ala Glu Glu His Gln Leu Leu Leu Glu Lys Glu Lys Leu Gln           
        435                 440                 445                       

gca aga cag cag cag ttg cta aag aaa att gaa cac gct cgg act tgc       1692
Ala Arg Gln Gln Gln Leu Leu Lys Lys Ile Glu His Ala Arg Thr Cys           
    450                 455                 460                           

tag acgcttctca aaactggaca gtcactgcca ctttgcacat tttgattttt            1745

tttttaaaca aacattgtgt tgacattaag aatgttggtt tactttcaaa tcggtcccct     1805

gtcgagttcg gctctgggtg ggcagtagga ccaccagtgt ggggttctgc tgggaccttg     1865

gagagcctgc atcccaggat gctgggtggc cctgcagcct cctccacctc acctccatga     1925

cagcgctaaa cgttggtgac ggttgggagc ctctggggct gttgaagtca ccttgtgtgt     1985

tccaagtttc caaacaacag aaagtcattc cttcttttta aaatggtgct taagttccag     2045

cagatgccac ataaggggtt tgccatttga tacccctggg gaacatttct gtaaatacca     2105

ttgacacatc cgccttttgt atacatcctg ggtaatgaga ggtggctttt gcggccagta     2165

ttagactgga agttcatacc taagtactgt aataatacct caatgtttga ggagcatgtt     2225

ttgtatacaa atatattgtt aatctctgtt atgtactgta ctaattctta cactgcctgt     2285

atactttagt atgacgctga tacataacta aatttgatac ttatattttc gtatgaaaat     2345

gagttgtgaa agttttgagt agatattact ttatcacttt ttgaactaag aaacttttgt     2405

aaagaaattt actatatata tatgcctttt tcctagcctg tttcttcctg ttaatgtatt     2465

tgttcatgtt tggtgcatag aactgggtaa atgcaaagtt ctgtgtttaa tttcttcaaa     2525

atgtatatat ttagtgctgc atcttatagc actttgaaat acctcatgtt tatgaaaata     2585

aatagcttaa aattaaatga aaaaaaaa                                        2613


<210>  26
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Pro Ser Cys Ser Thr Ser Thr Met Pro Gly Met Ile Cys Lys Asn 
1               5                   10                  15      


Pro Asp Leu Glu Phe Asp Ser Leu Gln Pro Cys Phe Tyr Pro Asp Glu 
            20                  25                  30          


Asp Asp Phe Tyr Phe Gly Gly Pro Asp Ser Thr Pro Pro Gly Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Gly Phe Ala Glu His Ser Ser Glu Pro Pro Ser Trp Val Thr Glu 
65                  70                  75                  80  


Met Leu Leu Glu Asn Glu Leu Trp Gly Ser Pro Ala Glu Glu Asp Ala 
                85                  90                  95      


Phe Gly Leu Gly Gly Leu Gly Gly Leu Thr Pro Asn Pro Val Ile Leu 
            100                 105                 110         


Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Arg Glu Lys Leu Glu Arg 
        115                 120                 125             


Ala Val Ser Glu Lys Leu Gln His Gly Arg Gly Pro Pro Thr Ala Gly 
    130                 135                 140                 


Ser Thr Ala Gln Ser Pro Gly Ala Gly Ala Ala Ser Pro Ala Gly Arg 
145                 150                 155                 160 


Gly His Gly Gly Ala Ala Gly Ala Gly Arg Ala Gly Ala Ala Leu Pro 
                165                 170                 175     


Ala Glu Leu Ala His Pro Ala Ala Glu Cys Val Asp Pro Ala Val Val 
            180                 185                 190         


Phe Pro Phe Pro Val Asn Lys Arg Glu Pro Ala Pro Val Pro Ala Ala 
        195                 200                 205             


Pro Ala Ser Ala Pro Ala Ala Gly Pro Ala Val Ala Ser Gly Ala Gly 
    210                 215                 220                 


Ile Ala Ala Pro Ala Gly Ala Pro Gly Val Ala Pro Pro Arg Pro Gly 
225                 230                 235                 240 


Gly Arg Gln Thr Ser Gly Gly Asp His Lys Ala Leu Ser Thr Ser Gly 
                245                 250                 255     


Glu Asp Thr Leu Ser Asp Ser Asp Asp Glu Asp Asp Glu Glu Glu Asp 
            260                 265                 270         


Glu Glu Glu Glu Ile Asp Val Val Thr Val Glu Lys Arg Arg Ser Ser 
        275                 280                 285             


Ser Asn Thr Lys Ala Val Thr Thr Phe Thr Ile Thr Val Arg Pro Lys 
    290                 295                 300                 


Asn Ala Ala Leu Gly Pro Gly Arg Ala Gln Ser Ser Glu Leu Ile Leu 
305                 310                 315                 320 


Lys Arg Cys Leu Pro Ile His Gln Gln His Asn Tyr Ala Ala Pro Ser 
                325                 330                 335     


Pro Tyr Val Glu Ser Glu Asp Ala Pro Pro Gln Lys Lys Ile Lys Ser 
            340                 345                 350         


Glu Ala Ser Pro Arg Pro Leu Lys Ser Val Ile Pro Pro Lys Ala Lys 
        355                 360                 365             


Ser Leu Ser Pro Arg Asn Ser Asp Ser Glu Asp Ser Glu Arg Arg Arg 
    370                 375                 380                 


Asn His Asn Ile Leu Glu Arg Gln Arg Arg Asn Asp Leu Arg Ser Ser 
385                 390                 395                 400 


Phe Leu Thr Leu Arg Asp His Val Pro Glu Leu Val Lys Asn Glu Lys 
                405                 410                 415     


Ala Ala Lys Val Val Ile Leu Lys Lys Ala Thr Glu Tyr Val His Ser 
            420                 425                 430         


Leu Gln Ala Glu Glu His Gln Leu Leu Leu Glu Lys Glu Lys Leu Gln 
        435                 440                 445             


Ala Arg Gln Gln Gln Leu Leu Lys Lys Ile Glu His Ala Arg Thr Cys 
    450                 455                 460                 


<210>  27
<211>  3622
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (582)..(1676)

<400>  27
aatgcgcctg cagctcgcgc tcccgcgccg atcccgagag cgtccgggcc gccgtgcgcg       60

agcgagggag ggcgcgcgcg cggggggggc gcgcttgtga gtgcgggccg cgctctcggc      120

ggcgcgcatg tgcgtgtgtg ctggctgccg ggctgccccg agccggcggg gagccggtcc      180

gctccaggtg gcgggcggct ggagcgaggt gaggctgcgg gtggccaggg cacgggcgcg      240

ggtcccgcgg tgcgggctgg ctgcaggctg ccttctgggc acggcgcgcc cccgcccggc      300

cccgccgggc cctgggagct gcgctccggg cggcgctggc aaagtttgct ttgaactcgc      360

tgcccacagt cgggtccgcg cgctgcgatt ggcttcccct accactctga cccggggccc      420

ggcttcccgg gacgcgagga ctgggcgcag gctgcaagct ggtggggttg gggaggaacg      480

agagcccggc agccgactgt gccgagggac ccggggacac ctccttcgcc cggccggcac      540

ccggtcagca cgtcccccct tccctcccgc agggagcgga c atg gac tac gac tcg      596
                                              Met Asp Tyr Asp Ser         
                                              1               5           

tac cag cac tat ttc tac gac tat gac tgc ggg gag gat ttc tac cgc        644
Tyr Gln His Tyr Phe Tyr Asp Tyr Asp Cys Gly Glu Asp Phe Tyr Arg           
                10                  15                  20                

tcc acg gcg ccc agc gag gac atc tgg aag aaa ttc gag ctg gtg cca        692
Ser Thr Ala Pro Ser Glu Asp Ile Trp Lys Lys Phe Glu Leu Val Pro           
            25                  30                  35                    

tcg ccc ccc acg tcg ccg ccc tgg ggc ttg ggt ccc ggc gca ggg gac        740
Ser Pro Pro Thr Ser Pro Pro Trp Gly Leu Gly Pro Gly Ala Gly Asp           
        40                  45                  50                        

ccg gcc ccc ggg att ggt ccc ccg gag ccg tgg ccc gga ggg tgc acc        788
Pro Ala Pro Gly Ile Gly Pro Pro Glu Pro Trp Pro Gly Gly Cys Thr           
    55                  60                  65                            

gga gac gaa gcg gaa tcc cgg ggc cac tcg aaa ggc tgg ggc agg aac        836
Gly Asp Glu Ala Glu Ser Arg Gly His Ser Lys Gly Trp Gly Arg Asn           
70                  75                  80                  85            

tac gcc tcc atc ata cgc cgt gac tgc atg tgg agc ggc ttc tcg gcc        884
Tyr Ala Ser Ile Ile Arg Arg Asp Cys Met Trp Ser Gly Phe Ser Ala           
                90                  95                  100               

cgg gaa cgg ctg gag aga gct gtg agc gac cgg ctc gct cct ggc gcg        932
Arg Glu Arg Leu Glu Arg Ala Val Ser Asp Arg Leu Ala Pro Gly Ala           
            105                 110                 115                   

ccc cgg ggg aac ccg ccc aag gcg tcc gcc gcc ccg gac tgc act ccc        980
Pro Arg Gly Asn Pro Pro Lys Ala Ser Ala Ala Pro Asp Cys Thr Pro           
        120                 125                 130                       

agc ctc gaa gcc ggc aac ccg gcg ccc gcc gcc ccc tgt ccg ctg ggc       1028
Ser Leu Glu Ala Gly Asn Pro Ala Pro Ala Ala Pro Cys Pro Leu Gly           
    135                 140                 145                           

gaa ccc aag acc cag gcc tgc tcc ggg tcc gag agc cca agc gac tcg       1076
Glu Pro Lys Thr Gln Ala Cys Ser Gly Ser Glu Ser Pro Ser Asp Ser           
150                 155                 160                 165           

gag aat gaa gaa att gat gtt gtg aca gta gag aag agg cag tct ctg       1124
Glu Asn Glu Glu Ile Asp Val Val Thr Val Glu Lys Arg Gln Ser Leu           
                170                 175                 180               

ggt att cgg aag ccg gtc acc atc acg gtg cga gca gac ccc ctg gat       1172
Gly Ile Arg Lys Pro Val Thr Ile Thr Val Arg Ala Asp Pro Leu Asp           
            185                 190                 195                   

ccc tgc atg aag cat ttc cac atc tcc atc cat cag caa cag cac aac       1220
Pro Cys Met Lys His Phe His Ile Ser Ile His Gln Gln Gln His Asn           
        200                 205                 210                       

tat gct gcc cgt ttt cct cca gaa agc tgc tcc caa gaa gag gct tca       1268
Tyr Ala Ala Arg Phe Pro Pro Glu Ser Cys Ser Gln Glu Glu Ala Ser           
    215                 220                 225                           

gag agg ggt ccc caa gaa gag gtt ctg gag aga gat gct gca ggg gaa       1316
Glu Arg Gly Pro Gln Glu Glu Val Leu Glu Arg Asp Ala Ala Gly Glu           
230                 235                 240                 245           

aag gaa gat gag gag gat gaa gag att gtg agt ccc cca cct gta gaa       1364
Lys Glu Asp Glu Glu Asp Glu Glu Ile Val Ser Pro Pro Pro Val Glu           
                250                 255                 260               

agt gag gct gcc cag tcc tgc cac ccc aaa cct gtc agt tct gat act       1412
Ser Glu Ala Ala Gln Ser Cys His Pro Lys Pro Val Ser Ser Asp Thr           
            265                 270                 275                   

gag gat gtg acc aag agg aag aat cac aac ttc ctg gag cgc aag agg       1460
Glu Asp Val Thr Lys Arg Lys Asn His Asn Phe Leu Glu Arg Lys Arg           
        280                 285                 290                       

cgg aat gac ctg cgt tcg cga ttc ttg gcg ctg agg gac cag gtg ccc       1508
Arg Asn Asp Leu Arg Ser Arg Phe Leu Ala Leu Arg Asp Gln Val Pro           
    295                 300                 305                           

acc ctg gcc agc tgc tcc aag gcc ccc aaa gta gtg atc cta agc aag       1556
Thr Leu Ala Ser Cys Ser Lys Ala Pro Lys Val Val Ile Leu Ser Lys           
310                 315                 320                 325           

gcc ttg gaa tac ttg caa gcc ctg gtg ggg gct gag aag agg atg gct       1604
Ala Leu Glu Tyr Leu Gln Ala Leu Val Gly Ala Glu Lys Arg Met Ala           
                330                 335                 340               

aca gag aaa aga cag ctc cga tgc cgg cag cag cag ttg cag aaa aga       1652
Thr Glu Lys Arg Gln Leu Arg Cys Arg Gln Gln Gln Leu Gln Lys Arg           
            345                 350                 355                   

att gca tac ctc act ggc tac taa ctgaccaaaa agcctgacag ttctgtctta      1706
Ile Ala Tyr Leu Thr Gly Tyr                                               
        360                                                               

cgaagacaca agtttatttt ttaacctccc tctccccttt agtaatttgc acattttggt     1766

tatggtggga cagtctggac agtagatccc agaatgcatt gcagccggtg cacacacaat     1826

aaaggcttgc attcttggaa accttgaaac ccagctctcc ctcttccctg actcatggga     1886

gtgctgtatg ttctctggcg cctttggctt cccagcaggc agctgactga ggagccttgg     1946

ggtctgccta gctcactagc tctgaagaaa aggctgacag atgctatgca acaggtggtg     2006

gatgttgtca ggggctccag cctgcatgaa atctcacact ctgcatgagc tttaggctag     2066

gaaaggatgc tcccaactgg tgtctctggg gtgatgcaag gacagctggg cctggatgct     2126

ctccctgagg ctcctttttc cagaagacac acgagctgtc ttgggtgaag acaagcttgc     2186

agacttgatc aacattgacc attacctcac tgtcagacac tttacagtag ccaaggagtt     2246

ggaaaccttt atatattatg atgttagctg acccccttcc tcccactccc aatgctgcga     2306

ccctgggaac acttaaaaag cttggcctct agattctttg tctcagagcc ctctgggctc     2366

tctcctctga gggagggacc tttctttcct cacaagggac ttttttgttc cattatgcct     2426

tgttatgcaa tgggctctac agcacccttt cccacaggtc agaaatattt ccccaagaca     2486

cagggaaatc ggtcctagcc tggggcctgg ggatagcttg gagtcctggc ccatgaactt     2546

gatccctgcc caggtgtttt ccgaggggca cttgaggccc agtcttttct caaggcaggt     2606

gtaagacacc tcagagggag aactgtactg ctgcctcttt cccacctgcc tcatctcaat     2666

ccttgagcgg caagtttgaa gttcttctgg aaccatgcaa atctgtcctc ctcatgcaat     2726

tccaaggagc ttgctggctc tgcagccacc cttgggcccc ttccagcctg ccatgaatca     2786

gatatctttc ccagaatctg ggcgtttctg aagttttggg gagagctgtt gggactcatc     2846

cagtgctcca gaaggtggac ttgcttctgg tgggttttaa aggagcctcc aggagatatg     2906

cttagccaac catgatggat tttaccccag ctggactcgg cagctccaag tggaatccac     2966

gtgcagcttc tagtctggga aagtcaccca acctagcagt tgtcatgtgg gtaacctcag     3026

gcacctctaa gcctgtcctg gaagaaggac cagcagcccc tccagaactc tgcccaggac     3086

agcaggtgcc tgctggctct gggtttggaa gttggggtgg gtagggggtg gtaagtacta     3146

tatatggctc tggaaaacca gctgctactt ccaaatctat tgtccataat ggtttctttc     3206

tgaggttgct tcttggcctc agaggacccc aggggatgtt tggaaatagc ctctctaccc     3266

ttctggagca tggtttacaa aagccagctg acttctggaa ttgtctatgg aggacagttt     3326

gggtgtaggt tactgatgtc tcaactgaat agcttgtgtt ttataagctg ctgttggcta     3386

ttatgctggg ggagtctttt ttttttatat tgtatttttg tatgcctttt gcaaagtggt     3446

gttaactgtt tttgtacaag gaaaaaaact cttggggcaa tttcctgttg caagggtctg     3506

atttattttg aaaggcaagt tcacctgaaa ttttgtattt agttgtgatt actgattgcc     3566

tgattttaaa atgttgcctt ctgggacatc ttctaataaa agatttctca aacatg         3622


<210>  28
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Asp Tyr Asp Ser Tyr Gln His Tyr Phe Tyr Asp Tyr Asp Cys Gly 
1               5                   10                  15      


Glu Asp Phe Tyr Arg Ser Thr Ala Pro Ser Glu Asp Ile Trp Lys Lys 
            20                  25                  30          


Phe Glu Leu Val Pro Ser Pro Pro Thr Ser Pro Pro Trp Gly Leu Gly 
        35                  40                  45              


Pro Gly Ala Gly Asp Pro Ala Pro Gly Ile Gly Pro Pro Glu Pro Trp 
    50                  55                  60                  


Pro Gly Gly Cys Thr Gly Asp Glu Ala Glu Ser Arg Gly His Ser Lys 
65                  70                  75                  80  


Gly Trp Gly Arg Asn Tyr Ala Ser Ile Ile Arg Arg Asp Cys Met Trp 
                85                  90                  95      


Ser Gly Phe Ser Ala Arg Glu Arg Leu Glu Arg Ala Val Ser Asp Arg 
            100                 105                 110         


Leu Ala Pro Gly Ala Pro Arg Gly Asn Pro Pro Lys Ala Ser Ala Ala 
        115                 120                 125             


Pro Asp Cys Thr Pro Ser Leu Glu Ala Gly Asn Pro Ala Pro Ala Ala 
    130                 135                 140                 


Pro Cys Pro Leu Gly Glu Pro Lys Thr Gln Ala Cys Ser Gly Ser Glu 
145                 150                 155                 160 


Ser Pro Ser Asp Ser Glu Asn Glu Glu Ile Asp Val Val Thr Val Glu 
                165                 170                 175     


Lys Arg Gln Ser Leu Gly Ile Arg Lys Pro Val Thr Ile Thr Val Arg 
            180                 185                 190         


Ala Asp Pro Leu Asp Pro Cys Met Lys His Phe His Ile Ser Ile His 
        195                 200                 205             


Gln Gln Gln His Asn Tyr Ala Ala Arg Phe Pro Pro Glu Ser Cys Ser 
    210                 215                 220                 


Gln Glu Glu Ala Ser Glu Arg Gly Pro Gln Glu Glu Val Leu Glu Arg 
225                 230                 235                 240 


Asp Ala Ala Gly Glu Lys Glu Asp Glu Glu Asp Glu Glu Ile Val Ser 
                245                 250                 255     


Pro Pro Pro Val Glu Ser Glu Ala Ala Gln Ser Cys His Pro Lys Pro 
            260                 265                 270         


Val Ser Ser Asp Thr Glu Asp Val Thr Lys Arg Lys Asn His Asn Phe 
        275                 280                 285             


Leu Glu Arg Lys Arg Arg Asn Asp Leu Arg Ser Arg Phe Leu Ala Leu 
    290                 295                 300                 


Arg Asp Gln Val Pro Thr Leu Ala Ser Cys Ser Lys Ala Pro Lys Val 
305                 310                 315                 320 


Val Ile Leu Ser Lys Ala Leu Glu Tyr Leu Gln Ala Leu Val Gly Ala 
                325                 330                 335     


Glu Lys Arg Met Ala Thr Glu Lys Arg Gln Leu Arg Cys Arg Gln Gln 
            340                 345                 350         


Gln Leu Gln Lys Arg Ile Ala Tyr Leu Thr Gly Tyr 
        355                 360                 


<210>  29
<211>  4865
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (253)..(2001)

<400>  29
gcagtgccgc cttttttttt tttttgcatc ccattttttt aaatttgcaa ttttatattt       60

tgcaaatatt ttgagagaca ttgatttttc tccccgtgct cccccgttct tccctgcgga      120

gtgcgctgcg ccgcccagcc ctgtcgcccc ccggaggtga tccctccctc ctgcctgccc      180

gccagcctga cctgtgcccg gctcgcgggc cgcagcctcg gccccggcgc gcccccggca      240

gctctcggcg cg atg agc ata gag acg cta ctg gag gcg gcc cgc ttc ctg      291
              Met Ser Ile Glu Thr Leu Leu Glu Ala Ala Arg Phe Leu         
              1               5                   10                      

gaa tgg caa gcg cag caa caa cag aga gca cgt gag gag cag gag cgg        339
Glu Trp Gln Ala Gln Gln Gln Gln Arg Ala Arg Glu Glu Gln Glu Arg           
    15                  20                  25                            

ctt cgc ttg gag cag gag cga gag cag gaa cag aag aag gcc aat agc        387
Leu Arg Leu Glu Gln Glu Arg Glu Gln Glu Gln Lys Lys Ala Asn Ser           
30                  35                  40                  45            

ctg gcc agg ctg gca cat acc ctt cct gtg gag gaa ccc cgc atg gag        435
Leu Ala Arg Leu Ala His Thr Leu Pro Val Glu Glu Pro Arg Met Glu           
                50                  55                  60                

gcg cca ccc ctg cct ctg tct cca ccg gct ccc ccg ccg gca ccc cca        483
Ala Pro Pro Leu Pro Leu Ser Pro Pro Ala Pro Pro Pro Ala Pro Pro           
            65                  70                  75                    

cca cca ctt gcc acc cct gcc cca ctg act gtc atc cct atc cct gtg        531
Pro Pro Leu Ala Thr Pro Ala Pro Leu Thr Val Ile Pro Ile Pro Val           
        80                  85                  90                        

gtg acc aac tcc cct cag cct cta ccc cca ccc cca ccc ttg ccc gcg        579
Val Thr Asn Ser Pro Gln Pro Leu Pro Pro Pro Pro Pro Leu Pro Ala           
    95                  100                 105                           

gca gcc cag cct ctg ccc ctg gcg cct cgt cag ccg gcc ctg gtt ggc        627
Ala Ala Gln Pro Leu Pro Leu Ala Pro Arg Gln Pro Ala Leu Val Gly           
110                 115                 120                 125           

gcc ccc gga ctc agc att aag gag cct gcc ccc ctg ccc agc agg ccg        675
Ala Pro Gly Leu Ser Ile Lys Glu Pro Ala Pro Leu Pro Ser Arg Pro           
                130                 135                 140               

cag gtg ccc acc cct gct ccc cta ctg ccg gac tcg aag gcc acc att        723
Gln Val Pro Thr Pro Ala Pro Leu Leu Pro Asp Ser Lys Ala Thr Ile           
            145                 150                 155                   

cca ccc aat ggc agc ccc aag cct ttg cag ccc ctc ccc acg cct gtc        771
Pro Pro Asn Gly Ser Pro Lys Pro Leu Gln Pro Leu Pro Thr Pro Val           
        160                 165                 170                       

ctg acc ata gcg cca cac cct gga gtc cag cct cag ctg gcc ccc cag        819
Leu Thr Ile Ala Pro His Pro Gly Val Gln Pro Gln Leu Ala Pro Gln           
    175                 180                 185                           

cag ccg ccc cca ccc acg ctg ggg acc ctg aag ttg gca cca gct gaa        867
Gln Pro Pro Pro Pro Thr Leu Gly Thr Leu Lys Leu Ala Pro Ala Glu           
190                 195                 200                 205           

gaa gtc aaa tcc agt gaa cag aag aag agg ccc ggg ggg atc gga acc        915
Glu Val Lys Ser Ser Glu Gln Lys Lys Arg Pro Gly Gly Ile Gly Thr           
                210                 215                 220               

aga gaa gtc cac aac aaa ttg gag aag aac agg agg gcc cat ctg aaa        963
Arg Glu Val His Asn Lys Leu Glu Lys Asn Arg Arg Ala His Leu Lys           
            225                 230                 235                   

gag tgc ttt gag acc ctg aag cgg aac atc ccc aac gtg gat gac aag       1011
Glu Cys Phe Glu Thr Leu Lys Arg Asn Ile Pro Asn Val Asp Asp Lys           
        240                 245                 250                       

aag acg tcc aat ctg agc gtg ctg cgg acg gcg ctg cgg tac atc cag       1059
Lys Thr Ser Asn Leu Ser Val Leu Arg Thr Ala Leu Arg Tyr Ile Gln           
    255                 260                 265                           

tcc ctg aag agg aag gag aag gaa tat gag cat gaa atg gag cgg ctg       1107
Ser Leu Lys Arg Lys Glu Lys Glu Tyr Glu His Glu Met Glu Arg Leu           
270                 275                 280                 285           

gca cgt gag aag att gcc acg cag cag cgg ctg gca gag ctc aag cac       1155
Ala Arg Glu Lys Ile Ala Thr Gln Gln Arg Leu Ala Glu Leu Lys His           
                290                 295                 300               

gag ctg agc cag tgg atg gac gta ctg gag att gac cgc gtg ctg cgg       1203
Glu Leu Ser Gln Trp Met Asp Val Leu Glu Ile Asp Arg Val Leu Arg           
            305                 310                 315                   

cag acg ggc cag ccc gag gat gac cag gcc tcc acc tcc acc gcc tct       1251
Gln Thr Gly Gln Pro Glu Asp Asp Gln Ala Ser Thr Ser Thr Ala Ser           
        320                 325                 330                       

gag ggt gag gac aac ata gac gag gat atg gag gag gac cgg gcg ggc       1299
Glu Gly Glu Asp Asn Ile Asp Glu Asp Met Glu Glu Asp Arg Ala Gly           
    335                 340                 345                           

ctg ggc cca cct aag ctg agc cat cgt ccc cag ccg gag ctg ctg aag       1347
Leu Gly Pro Pro Lys Leu Ser His Arg Pro Gln Pro Glu Leu Leu Lys           
350                 355                 360                 365           

tcc acc ctg cca ccc ccc agc acc acc cct gcg cct ctg cct cca cac       1395
Ser Thr Leu Pro Pro Pro Ser Thr Thr Pro Ala Pro Leu Pro Pro His           
                370                 375                 380               

cca cac cct cac ccc cac tcc gtg gcc cta cct cct gcc cac ctc ccc       1443
Pro His Pro His Pro His Ser Val Ala Leu Pro Pro Ala His Leu Pro           
            385                 390                 395                   

gtg cag cag cag cag cca cag cag aag acc cct ctg cca gcc cct cct       1491
Val Gln Gln Gln Gln Pro Gln Gln Lys Thr Pro Leu Pro Ala Pro Pro           
        400                 405                 410                       

ccc cca ccg gct gcc cct gcc cag aca ctg gtg cca gct cca gcc cat       1539
Pro Pro Pro Ala Ala Pro Ala Gln Thr Leu Val Pro Ala Pro Ala His           
    415                 420                 425                           

ctg gtg gcg acg gct ggg ggt ggc tcc acg gtc atc gcc cac aca gcc       1587
Leu Val Ala Thr Ala Gly Gly Gly Ser Thr Val Ile Ala His Thr Ala           
430                 435                 440                 445           

acc act cac gct tca gtc atc cag act gtg aac cac gtt ctg cag ggg       1635
Thr Thr His Ala Ser Val Ile Gln Thr Val Asn His Val Leu Gln Gly           
                450                 455                 460               

cca ggc ggc aag cac atc gcc cac atc gcc ccc tcg gcc ccc agc cct       1683
Pro Gly Gly Lys His Ile Ala His Ile Ala Pro Ser Ala Pro Ser Pro           
            465                 470                 475                   

gcg gtg caa ctg gcg cct gcc aca ccc ccc att ggg cac atc act gtg       1731
Ala Val Gln Leu Ala Pro Ala Thr Pro Pro Ile Gly His Ile Thr Val           
        480                 485                 490                       

cac cct gcc acc ctc aac cat gtg gcc cac ctg ggc tcc cag ctg ccc       1779
His Pro Ala Thr Leu Asn His Val Ala His Leu Gly Ser Gln Leu Pro           
    495                 500                 505                           

ttg tac ccg cag ccc gtg gca gtg agc cac atc gcc cac acc ctc tcg       1827
Leu Tyr Pro Gln Pro Val Ala Val Ser His Ile Ala His Thr Leu Ser           
510                 515                 520                 525           

cac cag caa gtc aac ggc acg gcc ggc ctg ggg ccc ccg gct act gtc       1875
His Gln Gln Val Asn Gly Thr Ala Gly Leu Gly Pro Pro Ala Thr Val           
                530                 535                 540               

atg gca aag ccg gcc gtg ggg gct cag gtg gtg cac cac ccc cag ctg       1923
Met Ala Lys Pro Ala Val Gly Ala Gln Val Val His His Pro Gln Leu           
            545                 550                 555                   

gtg ggc cag acc gtg ctc aac cct gtg acc atg gtc acc atg ccc tcc       1971
Val Gly Gln Thr Val Leu Asn Pro Val Thr Met Val Thr Met Pro Ser           
        560                 565                 570                       

ttc cca gtc agc aca ctc aag ctg gct tga ggacgaggcc actcagaggc         2021
Phe Pro Val Ser Thr Leu Lys Leu Ala                                       
    575                 580                                               

ccccagtggg gacagggagg gggacctgtc ccccactctc tcacccacca gctccacaca     2081

ttccagccag gcccaggcca gcccccccac ccacccccag gcctcctagg ggaagggggt     2141

gcaaagactc tgagccaagg gagggaaggg ccaccctgct gcactaggac ttggtaagat     2201

gactctgaga aaatgcgaga ctctgatgga atgtgccacc tgtccggccc agtgccagct     2261

ccagtgccgc tcctgcttcc cctccctacc ctcggaaatc agtgcgatgt ggacgtcacg     2321

ctccctgact tctcccccgc cctgccccgc cttcgtgtgc tgctgctgct attgctgtct     2381

ggtgaggtgg cccaggcccc cggctttcct ccggagcctc atgttctctt cccaggcctt     2441

tggaggggaa atggggaaag cagaactgaa gccacttggc ccagaaagct gcggattggg     2501

gtgataaggg gccttgctct gagcacaggt gacagatcat aggaagtggc tggtctggag     2561

tcccacccgg acaggtgggg cctcagcctg gggctctctg acccggttgc agtcactgtg     2621

attcgttacc gtagatacta cttaaaatga ttctctacca acaataaacc aaacccagcc     2681

actgccaagc ttcctgtgcc ctcaccccaa tccctgccac tgggctctgg acctcaggag     2741

ggcaggctga ggtggggaag gagggacttg gctgtccttc cccttccccg tcccctgcag     2801

cctgggtctg gatgggagga gagccactgg gcccctgtcc ccagtcccca gtccccagcc     2861

ctgggcttgg ctcttggctt ccagaaggca gcaaagaggg gcgctgtcct gcgttcagcc     2921

cctgatctct gacctctgct gagtgctggg cactgctcca agggacaggt gggcctggcg     2981

gcctgtgggt ttgggtgcct cctgcagttt gggagacatg gaccagcatc tggtcttgtt     3041

tccaggagca tagaagccac atcgttgaga catcaggaag gtaaaaaccc agcggcttag     3101

ccaagcccta agcctgtccc cagaccaacc ctgggaccta tacagaacag agggccagag     3161

ctagggctgc tgcttctgct ccagcccctt tgcctctgtc ctcccatccc ctcaacaccc     3221

tgcttctccc ggggacgctt ttgagtgggc cctgcccggg gagctgcaga gcagcagcac     3281

ctttctctga gaagaggtcc ttggttgggt caaggacagg gctgagcgtg gaagggggag     3341

gagtcagggg ctctgtgtta ggatgcggct ttctctgcct ctgggcagcc tgctttggcc     3401

tttccttgta tgtgggtgtt tattacaagt ggctttgtgt cagacacgct cggctcccca     3461

cctggacaca cactcaccag tggcctttca gtgtagcggg aggaagccgg tgtccctgga     3521

tgtgaagctc acactgatgg gctggggcag gggcctgggc cggcgagggg gccgggggga     3581

ggggacagag ctgaggattt cctggagtgc cctgcaggca cagaggaggt cagcaaaggt     3641

cttgaataga ttttctctgg aaataaagaa tccttagatg cctaaaaatt cccttcctgt     3701

tccctcctgg tcctggacac ctcccagggg actgttcctt atttctctct cctggtgtgg     3761

gtaaagggac agttacaaac caggtcacca tcctcagagg ctgagccctg tacccacccc     3821

agcacagcca cctccgccag accccgtggc tctgggagag ccagctttgc tattcccatt     3881

gtgacagcga tggcaggcct gacccacggg gcagttagag cagcctcgtg gagctcgccc     3941

ctcccctcag cctgcccacc tctccctgca tcctgaggcc agtggccccc gggcctgcac     4001

agatacctca tcatccaccc gctgcccctc cccgtccctg tcccccagca tcgggggcct     4061

gcaaatctag tgccgaatga ctatgtccag attggtgacg atgggtgttg ctgtttttct     4121

tgtcgtttgt gaacgctgtg atgctgtgtg cccaagtggg cagtcaccac ccagcccttc     4181

cttgggcgtc tcccccagag tgctgtcggg accacatctg tcctcaccct gtgggaccgc     4241

ctggccctcc ctccctagcc cttccagcct gggacacaca cacacacaca cacacacaca     4301

cacgcacgca cacgcacaca tcttacctct catgcgtgtt ttaccttttg atgttcagag     4361

tggctcactg gctgggagtc cttacctcgg ggagaggggg aggttggttc cttggggggc     4421

caaagaaggc agggaatgcc tggagggtaa ctggggggcc accatgaccc cttctctctc     4481

cagaaacagc tgcttctccc cccatcccag ggtcccaccc ccaaccccca gaggtggccc     4541

ttgtttacag tgaggactcg gccactgtgt ctctgtttcc tgaaatataa actgtagcga     4601

ccccagactg tagagatttt tatgtgtttg gatacatctg ctgtgtggaa aaaaaaaaaa     4661

actacaaaaa ccctaatttt gtacatactg tatttttact attgaactgt attctagtgg     4721

ctgttcatgc tccaagactt tagttaccga gacatgaata ctatccatgt aataagcact     4781

tgcctggaat aaaatataaa actgaaataa acctgcactg aaacctgaga tggagctgcc     4841

aaaaaaaaaa aaaaaaaaaa aaaa                                            4865


<210>  30
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Ile Glu Thr Leu Leu Glu Ala Ala Arg Phe Leu Glu Trp Gln 
1               5                   10                  15      


Ala Gln Gln Gln Gln Arg Ala Arg Glu Glu Gln Glu Arg Leu Arg Leu 
            20                  25                  30          


Glu Gln Glu Arg Glu Gln Glu Gln Lys Lys Ala Asn Ser Leu Ala Arg 
        35                  40                  45              


Leu Ala His Thr Leu Pro Val Glu Glu Pro Arg Met Glu Ala Pro Pro 
    50                  55                  60                  


Leu Pro Leu Ser Pro Pro Ala Pro Pro Pro Ala Pro Pro Pro Pro Leu 
65                  70                  75                  80  


Ala Thr Pro Ala Pro Leu Thr Val Ile Pro Ile Pro Val Val Thr Asn 
                85                  90                  95      


Ser Pro Gln Pro Leu Pro Pro Pro Pro Pro Leu Pro Ala Ala Ala Gln 
            100                 105                 110         


Pro Leu Pro Leu Ala Pro Arg Gln Pro Ala Leu Val Gly Ala Pro Gly 
        115                 120                 125             


Leu Ser Ile Lys Glu Pro Ala Pro Leu Pro Ser Arg Pro Gln Val Pro 
    130                 135                 140                 


Thr Pro Ala Pro Leu Leu Pro Asp Ser Lys Ala Thr Ile Pro Pro Asn 
145                 150                 155                 160 


Gly Ser Pro Lys Pro Leu Gln Pro Leu Pro Thr Pro Val Leu Thr Ile 
                165                 170                 175     


Ala Pro His Pro Gly Val Gln Pro Gln Leu Ala Pro Gln Gln Pro Pro 
            180                 185                 190         


Pro Pro Thr Leu Gly Thr Leu Lys Leu Ala Pro Ala Glu Glu Val Lys 
        195                 200                 205             


Ser Ser Glu Gln Lys Lys Arg Pro Gly Gly Ile Gly Thr Arg Glu Val 
    210                 215                 220                 


His Asn Lys Leu Glu Lys Asn Arg Arg Ala His Leu Lys Glu Cys Phe 
225                 230                 235                 240 


Glu Thr Leu Lys Arg Asn Ile Pro Asn Val Asp Asp Lys Lys Thr Ser 
                245                 250                 255     


Asn Leu Ser Val Leu Arg Thr Ala Leu Arg Tyr Ile Gln Ser Leu Lys 
            260                 265                 270         


Arg Lys Glu Lys Glu Tyr Glu His Glu Met Glu Arg Leu Ala Arg Glu 
        275                 280                 285             


Lys Ile Ala Thr Gln Gln Arg Leu Ala Glu Leu Lys His Glu Leu Ser 
    290                 295                 300                 


Gln Trp Met Asp Val Leu Glu Ile Asp Arg Val Leu Arg Gln Thr Gly 
305                 310                 315                 320 


Gln Pro Glu Asp Asp Gln Ala Ser Thr Ser Thr Ala Ser Glu Gly Glu 
                325                 330                 335     


Asp Asn Ile Asp Glu Asp Met Glu Glu Asp Arg Ala Gly Leu Gly Pro 
            340                 345                 350         


Pro Lys Leu Ser His Arg Pro Gln Pro Glu Leu Leu Lys Ser Thr Leu 
        355                 360                 365             


Pro Pro Pro Ser Thr Thr Pro Ala Pro Leu Pro Pro His Pro His Pro 
    370                 375                 380                 


His Pro His Ser Val Ala Leu Pro Pro Ala His Leu Pro Val Gln Gln 
385                 390                 395                 400 


Gln Gln Pro Gln Gln Lys Thr Pro Leu Pro Ala Pro Pro Pro Pro Pro 
                405                 410                 415     


Ala Ala Pro Ala Gln Thr Leu Val Pro Ala Pro Ala His Leu Val Ala 
            420                 425                 430         


Thr Ala Gly Gly Gly Ser Thr Val Ile Ala His Thr Ala Thr Thr His 
        435                 440                 445             


Ala Ser Val Ile Gln Thr Val Asn His Val Leu Gln Gly Pro Gly Gly 
    450                 455                 460                 


Lys His Ile Ala His Ile Ala Pro Ser Ala Pro Ser Pro Ala Val Gln 
465                 470                 475                 480 


Leu Ala Pro Ala Thr Pro Pro Ile Gly His Ile Thr Val His Pro Ala 
                485                 490                 495     


Thr Leu Asn His Val Ala His Leu Gly Ser Gln Leu Pro Leu Tyr Pro 
            500                 505                 510         


Gln Pro Val Ala Val Ser His Ile Ala His Thr Leu Ser His Gln Gln 
        515                 520                 525             


Val Asn Gly Thr Ala Gly Leu Gly Pro Pro Ala Thr Val Met Ala Lys 
    530                 535                 540                 


Pro Ala Val Gly Ala Gln Val Val His His Pro Gln Leu Val Gly Gln 
545                 550                 555                 560 


Thr Val Leu Asn Pro Val Thr Met Val Thr Met Pro Ser Phe Pro Val 
                565                 570                 575     


Ser Thr Leu Lys Leu Ala 
            580         


<210>  31
<211>  826
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Glu Gly Ala Gly Gly Ala Asn Asp Lys Lys Lys Ile Ser Ser Glu 
1               5                   10                  15      


Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys 
            20                  25                  30          


Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His 
        35                  40                  45              


Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile 
    50                  55                  60                  


Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Asp Leu Asp Ile 
65                  70                  75                  80  


Glu Asp Asp Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala Leu 
                85                  90                  95      


Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr Ile 
            100                 105                 110         


Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr 
        115                 120                 125             


Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met 
    130                 135                 140                 


Arg Glu Met Leu Thr His Arg Asn Gly Leu Val Lys Lys Gly Lys Glu 
145                 150                 155                 160 


Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr 
                165                 170                 175     


Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu 
            180                 185                 190         


His Cys Thr Gly His Ile His Val Tyr Asp Thr Asn Ser Asn Gln Pro 
        195                 200                 205             


Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys 
    210                 215                 220                 


Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys 
225                 230                 235                 240 


Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp 
                245                 250                 255     


Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly 
            260                 265                 270         


Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr 
        275                 280                 285             


Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln 
    290                 295                 300                 


Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr Gln 
305                 310                 315                 320 


Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val 
                325                 330                 335     


Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe 
            340                 345                 350         


Ser Leu Gln Gln Thr Glu Cys Val Leu Lys Pro Val Glu Ser Ser Asp 
        355                 360                 365             


Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser 
    370                 375                 380                 


Ser Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu 
385                 390                 395                 400 


Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn 
                405                 410                 415     


Asp Thr Glu Thr Asp Asp Gln Gln Leu Glu Glu Val Pro Leu Tyr Asn 
            420                 425                 430         


Asp Val Met Leu Pro Ser Pro Asn Glu Lys Leu Gln Asn Ile Asn Leu 
        435                 440                 445             


Ala Met Ser Pro Leu Pro Thr Ala Glu Thr Pro Lys Pro Leu Arg Ser 
    450                 455                 460                 


Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Pro 
465                 470                 475                 480 


Asn Pro Glu Ser Leu Glu Leu Ser Phe Thr Met Pro Gln Ile Gln Asp 
                485                 490                 495     


Gln Thr Pro Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu 
            500                 505                 510         


Pro Asn Ser Pro Ser Glu Tyr Cys Phe Tyr Val Asp Ser Asp Met Val 
        515                 520                 525             


Asn Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr 
    530                 535                 540                 


Glu Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu 
545                 550                 555                 560 


Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser 
                565                 570                 575     


Phe Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser 
            580                 585                 590         


Ala Ser Pro Gln Ser Thr Val Thr Val Phe Gln Gln Thr Gln Ile Gln 
        595                 600                 605             


Glu Pro Thr Ala Asn Ala Thr Thr Thr Thr Ala Thr Thr Asp Glu Leu 
    610                 615                 620                 


Lys Thr Val Thr Lys Asp Arg Met Glu Asp Ile Lys Ile Leu Ile Ala 
625                 630                 635                 640 


Ser Pro Ser Pro Thr His Ile His Lys Glu Thr Thr Ser Ala Thr Ser 
                645                 650                 655     


Ser Pro Tyr Arg Asp Thr Gln Ser Arg Thr Ala Ser Pro Asn Arg Ala 
            660                 665                 670         


Gly Lys Gly Val Ile Glu Gln Thr Glu Lys Ser His Pro Arg Ser Pro 
        675                 680                 685             


Asn Val Leu Ser Val Ala Leu Ser Gln Arg Thr Thr Val Pro Glu Glu 
    690                 695                 700                 


Glu Leu Asn Pro Lys Ile Leu Ala Leu Gln Asn Ala Gln Arg Lys Arg 
705                 710                 715                 720 


Lys Met Glu His Asp Gly Ser Leu Phe Gln Ala Val Gly Ile Gly Thr 
                725                 730                 735     


Leu Leu Gln Gln Pro Asp Asp His Ala Ala Thr Thr Ser Leu Ser Trp 
            740                 745                 750         


Lys Arg Val Lys Gly Cys Lys Ser Ser Glu Gln Asn Gly Met Glu Gln 
        755                 760                 765             


Lys Thr Ile Ile Leu Ile Pro Ser Asp Leu Ala Cys Arg Leu Leu Gly 
    770                 775                 780                 


Gln Ser Met Asp Glu Ser Gly Leu Pro Gln Leu Thr Ser Tyr Asp Cys 
785                 790                 795                 800 


Glu Val Asn Ala Pro Ile Gln Gly Ser Arg Asn Leu Leu Gln Gly Glu 
                805                 810                 815     


Glu Leu Leu Arg Ala Leu Asp Gln Val Asn 
            820                 825     


<210>  32
<211>  735
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Glu Gly Ala Gly Gly Ala Asn Asp Lys Lys Lys Ile Ser Ser Glu 
1               5                   10                  15      


Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys 
            20                  25                  30          


Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His 
        35                  40                  45              


Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile 
    50                  55                  60                  


Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Asp Leu Asp Ile 
65                  70                  75                  80  


Glu Asp Asp Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala Leu 
                85                  90                  95      


Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr Ile 
            100                 105                 110         


Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr 
        115                 120                 125             


Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met 
    130                 135                 140                 


Arg Glu Met Leu Thr His Arg Asn Gly Leu Val Lys Lys Gly Lys Glu 
145                 150                 155                 160 


Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr 
                165                 170                 175     


Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu 
            180                 185                 190         


His Cys Thr Gly His Ile His Val Tyr Asp Thr Asn Ser Asn Gln Pro 
        195                 200                 205             


Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys 
    210                 215                 220                 


Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys 
225                 230                 235                 240 


Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp 
                245                 250                 255     


Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly 
            260                 265                 270         


Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr 
        275                 280                 285             


Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln 
    290                 295                 300                 


Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr Gln 
305                 310                 315                 320 


Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val 
                325                 330                 335     


Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe 
            340                 345                 350         


Ser Leu Gln Gln Thr Glu Cys Val Leu Lys Pro Val Glu Ser Ser Asp 
        355                 360                 365             


Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser 
    370                 375                 380                 


Ser Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu 
385                 390                 395                 400 


Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn 
                405                 410                 415     


Asp Thr Glu Thr Asp Asp Gln Gln Leu Glu Glu Val Pro Leu Tyr Asn 
            420                 425                 430         


Asp Val Met Leu Pro Ser Pro Asn Glu Lys Leu Gln Asn Ile Asn Leu 
        435                 440                 445             


Ala Met Ser Pro Leu Pro Thr Ala Glu Thr Pro Lys Pro Leu Arg Ser 
    450                 455                 460                 


Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Pro 
465                 470                 475                 480 


Asn Pro Glu Ser Leu Glu Leu Ser Phe Thr Met Pro Gln Ile Gln Asp 
                485                 490                 495     


Gln Thr Pro Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu 
            500                 505                 510         


Pro Asn Ser Pro Ser Glu Tyr Cys Phe Tyr Val Asp Ser Asp Met Val 
        515                 520                 525             


Asn Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr 
    530                 535                 540                 


Glu Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu 
545                 550                 555                 560 


Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser 
                565                 570                 575     


Phe Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser 
            580                 585                 590         


Ala Ser Pro Gln Ser Thr Val Thr Val Phe Gln Gln Thr Gln Ile Gln 
        595                 600                 605             


Glu Pro Thr Ala Asn Ala Thr Thr Thr Thr Ala Thr Thr Asp Glu Leu 
    610                 615                 620                 


Lys Thr Val Thr Lys Asp Arg Met Glu Asp Ile Lys Ile Leu Ile Ala 
625                 630                 635                 640 


Ser Pro Ser Pro Thr His Ile His Lys Glu Thr Thr Ser Ala Thr Ser 
                645                 650                 655     


Ser Pro Tyr Arg Asp Thr Gln Ser Arg Thr Ala Ser Pro Asn Arg Ala 
            660                 665                 670         


Gly Lys Gly Val Ile Glu Gln Thr Glu Lys Ser His Pro Arg Ser Pro 
        675                 680                 685             


Asn Val Leu Ser Val Ala Leu Ser Gln Arg Thr Thr Val Pro Glu Glu 
    690                 695                 700                 


Glu Leu Asn Pro Lys Ile Leu Ala Leu Gln Asn Ala Gln Arg Lys Arg 
705                 710                 715                 720 


Lys Met Glu His Asp Gly Ser Leu Phe Gln Ala Val Gly Ile Ile 
                725                 730                 735 


<210>  33
<211>  789
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Ala Thr Thr Ala Asn Pro Glu Met Thr Ser Asp Val Pro Ser 
1               5                   10                  15      


Leu Gly Pro Ala Ile Ala Ser Gly Asn Ser Gly Pro Gly Ile Gln Gly 
            20                  25                  30          


Gly Gly Ala Ile Val Gln Arg Ala Ile Lys Arg Arg Pro Gly Leu Asp 
        35                  40                  45              


Phe Asp Asp Asp Gly Glu Gly Asn Ser Lys Phe Leu Arg Cys Asp Asp 
    50                  55                  60                  


Asp Gln Met Ser Asn Asp Lys Glu Arg Phe Ala Arg Ser Asp Asp Glu 
65                  70                  75                  80  


Gln Ser Ser Ala Asp Lys Glu Arg Leu Ala Arg Glu Asn His Ser Glu 
                85                  90                  95      


Ile Glu Arg Arg Arg Arg Asn Lys Met Thr Ala Tyr Ile Thr Glu Leu 
            100                 105                 110         


Ser Asp Met Val Pro Thr Cys Ser Ala Leu Ala Arg Lys Pro Asp Lys 
        115                 120                 125             


Leu Thr Ile Leu Arg Met Ala Val Ser His Met Lys Ser Leu Arg Gly 
    130                 135                 140                 


Thr Gly Asn Thr Ser Thr Asp Gly Ser Tyr Lys Pro Ser Phe Leu Thr 
145                 150                 155                 160 


Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe Leu 
                165                 170                 175     


Phe Ile Val Ser Cys Glu Thr Gly Arg Val Val Tyr Val Ser Asp Ser 
            180                 185                 190         


Val Thr Pro Val Leu Asn Gln Pro Gln Ser Glu Trp Phe Gly Ser Thr 
        195                 200                 205             


Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu Gln 
    210                 215                 220                 


Leu Ser Thr Ser Glu Asn Ala Leu Thr Gly Arg Ile Leu Asp Leu Lys 
225                 230                 235                 240 


Thr Gly Thr Val Lys Lys Glu Gly Gln Gln Ser Ser Met Arg Met Cys 
                245                 250                 255     


Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg Cys Gly Ser Ser 
            260                 265                 270         


Ser Val Asp Pro Val Ser Val Asn Arg Leu Ser Phe Val Arg Asn Arg 
        275                 280                 285             


Cys Arg Asn Gly Leu Gly Ser Val Lys Asp Gly Glu Pro His Phe Val 
    290                 295                 300                 


Val Val His Cys Thr Gly Tyr Ile Lys Ala Trp Pro Pro Ala Gly Val 
305                 310                 315                 320 


Ser Leu Pro Asp Asp Asp Pro Glu Ala Gly Gln Gly Ser Lys Phe Cys 
                325                 330                 335     


Leu Val Ala Ile Gly Arg Leu Gln Val Thr Ser Ser Pro Asn Cys Thr 
            340                 345                 350         


Asp Met Ser Asn Val Cys Gln Pro Thr Glu Phe Ile Ser Arg His Asn 
        355                 360                 365             


Ile Glu Gly Ile Phe Thr Phe Val Asp His Arg Cys Val Ala Thr Val 
    370                 375                 380                 


Gly Tyr Gln Pro Gln Glu Leu Leu Gly Lys Asn Ile Val Glu Phe Cys 
385                 390                 395                 400 


His Pro Glu Asp Gln Gln Leu Leu Arg Asp Ser Phe Gln Gln Val Val 
                405                 410                 415     


Lys Leu Lys Gly Gln Val Leu Ser Val Met Phe Arg Phe Arg Ser Lys 
            420                 425                 430         


Asn Gln Glu Trp Leu Trp Met Arg Thr Ser Ser Phe Thr Phe Gln Asn 
        435                 440                 445             


Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile Cys Thr Asn Thr Asn Val 
    450                 455                 460                 


Lys Asn Ser Ser Gln Glu Pro Arg Pro Thr Leu Ser Asn Thr Ile Gln 
465                 470                 475                 480 


Arg Pro Gln Leu Gly Pro Thr Ala Asn Leu Pro Leu Glu Met Gly Ser 
                485                 490                 495     


Gly Gln Leu Ala Pro Arg Gln Gln Gln Gln Gln Thr Glu Leu Asp Met 
            500                 505                 510         


Val Pro Gly Arg Asp Gly Leu Ala Ser Tyr Asn His Ser Gln Val Val 
        515                 520                 525             


Gln Pro Val Thr Thr Thr Gly Pro Glu His Ser Lys Pro Leu Glu Lys 
    530                 535                 540                 


Ser Asp Gly Leu Phe Ala Gln Asp Arg Asp Pro Arg Phe Ser Glu Ile 
545                 550                 555                 560 


Tyr His Asn Ile Asn Ala Asp Gln Ser Lys Gly Ile Ser Ser Ser Thr 
                565                 570                 575     


Val Pro Ala Thr Gln Gln Leu Phe Ser Gln Gly Asn Thr Phe Pro Pro 
            580                 585                 590         


Thr Pro Arg Pro Ala Glu Asn Phe Arg Asn Ser Gly Leu Ala Pro Pro 
        595                 600                 605             


Val Thr Ile Val Gln Pro Ser Ala Ser Ala Gly Gln Met Leu Ala Gln 
    610                 615                 620                 


Ile Ser Arg His Ser Asn Pro Thr Gln Gly Ala Thr Pro Thr Trp Thr 
625                 630                 635                 640 


Pro Thr Thr Arg Ser Gly Phe Ser Ala Gln Gln Val Ala Thr Gln Ala 
                645                 650                 655     


Thr Ala Lys Thr Arg Thr Ser Gln Phe Gly Val Gly Ser Phe Gln Thr 
            660                 665                 670         


Pro Ser Ser Phe Ser Ser Met Ser Leu Pro Gly Ala Pro Thr Ala Ser 
        675                 680                 685             


Pro Gly Ala Ala Ala Tyr Pro Ser Leu Thr Asn Arg Gly Ser Asn Phe 
    690                 695                 700                 


Ala Pro Glu Thr Gly Gln Thr Ala Gly Gln Phe Gln Thr Arg Thr Ala 
705                 710                 715                 720 


Glu Gly Val Gly Val Trp Pro Gln Trp Gln Gly Gln Gln Pro His His 
                725                 730                 735     


Arg Ser Ser Ser Ser Glu Gln His Val Gln Gln Pro Pro Ala Gln Gln 
            740                 745                 750         


Pro Gly Gln Pro Glu Val Phe Gln Glu Met Leu Ser Met Leu Gly Asp 
        755                 760                 765             


Gln Ser Asn Ser Tyr Asn Asn Glu Glu Phe Pro Asp Leu Thr Met Phe 
    770                 775                 780                 


Pro Pro Phe Ser Glu 
785                 


<210>  34
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Ala Thr Thr Ala Asn Pro Glu Met Thr Ser Asp Val Pro Ser 
1               5                   10                  15      


Leu Gly Pro Ala Ile Ala Ser Gly Asn Ser Gly Pro Gly Ile Gln Gly 
            20                  25                  30          


Gly Gly Ala Ile Val Gln Arg Ala Ile Lys Arg Arg Pro Gly Leu Asp 
        35                  40                  45              


Phe Asp Asp Asp Gly Glu Gly Asn Ser Lys Phe Leu Arg Cys Asp Asp 
    50                  55                  60                  


Asp Gln Met Ser Asn Asp Lys Glu Arg Phe Ala Arg Ser Asp Asp Glu 
65                  70                  75                  80  


Gln Ser Ser Ala Asp Lys Glu Arg Leu Ala Arg Glu Asn His Ser Glu 
                85                  90                  95      


Ile Glu Arg Arg Arg Arg Asn Lys Met Thr Ala Tyr Ile Thr Glu Leu 
            100                 105                 110         


Ser Asp Met Val Pro Thr Cys Ser Ala Leu Ala Arg Lys Pro Asp Lys 
        115                 120                 125             


Leu Thr Ile Leu Arg Met Ala Val Ser His Met Lys Ser Leu Arg Gly 
    130                 135                 140                 


Thr Gly Asn Thr Ser Thr Asp Gly Ser Tyr Lys Pro Ser Phe Leu Thr 
145                 150                 155                 160 


Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe Leu 
                165                 170                 175     


Phe Ile Val Ser Cys Glu Thr Gly Arg Val Val Tyr Val Ser Asp Ser 
            180                 185                 190         


Val Thr Pro Val Leu Asn Gln Pro Gln Ser Glu Trp Phe Gly Ser Thr 
        195                 200                 205             


Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu Gln 
    210                 215                 220                 


Leu Ser Thr Ser Glu Asn Ala Leu Thr Gly Arg Ile Leu Asp Leu Lys 
225                 230                 235                 240 


Thr Gly Thr Val Lys Lys Glu Gly Gln Gln Ser Ser Met Arg Met Cys 
                245                 250                 255     


Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg Cys Gly Ser Ser 
            260                 265                 270         


Ser Val Asp Pro Val Ser Val Asn Arg Leu Ser Phe Val Arg Asn Arg 
        275                 280                 285             


Cys Arg Asn Gly Leu Gly Ser Val Lys Asp Gly Glu Pro His Phe Val 
    290                 295                 300                 


Val Val His Cys Thr Gly Tyr Ile Lys Ala Trp Pro Pro Ala Gly Val 
305                 310                 315                 320 


Ser Leu Pro Asp Asp Asp Pro Ala 
                325             


<210>  35
<211>  774
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Ala Thr Thr Ala Asn Pro Glu Met Thr Ser Asp Val Pro Ser 
1               5                   10                  15      


Leu Gly Pro Ala Ile Ala Ser Gly Asn Ser Gly Pro Gly Ile Gln Gly 
            20                  25                  30          


Gly Gly Ala Ile Val Gln Arg Ala Ile Lys Arg Arg Pro Gly Leu Asp 
        35                  40                  45              


Phe Asp Asp Asp Gly Glu Gly Asn Ser Lys Phe Leu Arg Cys Asp Asp 
    50                  55                  60                  


Asp Gln Met Ser Asn Asp Lys Glu Arg Phe Ala Arg Glu Asn His Ser 
65                  70                  75                  80  


Glu Ile Glu Arg Arg Arg Arg Asn Lys Met Thr Ala Tyr Ile Thr Glu 
                85                  90                  95      


Leu Ser Asp Met Val Pro Thr Cys Ser Ala Leu Ala Arg Lys Pro Asp 
            100                 105                 110         


Lys Leu Thr Ile Leu Arg Met Ala Val Ser His Met Lys Ser Leu Arg 
        115                 120                 125             


Gly Thr Gly Asn Thr Ser Thr Asp Gly Ser Tyr Lys Pro Ser Phe Leu 
    130                 135                 140                 


Thr Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe 
145                 150                 155                 160 


Leu Phe Ile Val Ser Cys Glu Thr Gly Arg Val Val Tyr Val Ser Asp 
                165                 170                 175     


Ser Val Thr Pro Val Leu Asn Gln Pro Gln Ser Glu Trp Phe Gly Ser 
            180                 185                 190         


Thr Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu 
        195                 200                 205             


Gln Leu Ser Thr Ser Glu Asn Ala Leu Thr Gly Arg Ile Leu Asp Leu 
    210                 215                 220                 


Lys Thr Gly Thr Val Lys Lys Glu Gly Gln Gln Ser Ser Met Arg Met 
225                 230                 235                 240 


Cys Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg Cys Gly Ser 
                245                 250                 255     


Ser Ser Val Asp Pro Val Ser Val Asn Arg Leu Ser Phe Val Arg Asn 
            260                 265                 270         


Arg Cys Arg Asn Gly Leu Gly Ser Val Lys Asp Gly Glu Pro His Phe 
        275                 280                 285             


Val Val Val His Cys Thr Gly Tyr Ile Lys Ala Trp Pro Pro Ala Gly 
    290                 295                 300                 


Val Ser Leu Pro Asp Asp Asp Pro Glu Ala Gly Gln Gly Ser Lys Phe 
305                 310                 315                 320 


Cys Leu Val Ala Ile Gly Arg Leu Gln Val Thr Ser Ser Pro Asn Cys 
                325                 330                 335     


Thr Asp Met Ser Asn Val Cys Gln Pro Thr Glu Phe Ile Ser Arg His 
            340                 345                 350         


Asn Ile Glu Gly Ile Phe Thr Phe Val Asp His Arg Cys Val Ala Thr 
        355                 360                 365             


Val Gly Tyr Gln Pro Gln Glu Leu Leu Gly Lys Asn Ile Val Glu Phe 
    370                 375                 380                 


Cys His Pro Glu Asp Gln Gln Leu Leu Arg Asp Ser Phe Gln Gln Val 
385                 390                 395                 400 


Val Lys Leu Lys Gly Gln Val Leu Ser Val Met Phe Arg Phe Arg Ser 
                405                 410                 415     


Lys Asn Gln Glu Trp Leu Trp Met Arg Thr Ser Ser Phe Thr Phe Gln 
            420                 425                 430         


Asn Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile Cys Thr Asn Thr Asn 
        435                 440                 445             


Val Lys Asn Ser Ser Gln Glu Pro Arg Pro Thr Leu Ser Asn Thr Ile 
    450                 455                 460                 


Gln Arg Pro Gln Leu Gly Pro Thr Ala Asn Leu Pro Leu Glu Met Gly 
465                 470                 475                 480 


Ser Gly Gln Leu Ala Pro Arg Gln Gln Gln Gln Gln Thr Glu Leu Asp 
                485                 490                 495     


Met Val Pro Gly Arg Asp Gly Leu Ala Ser Tyr Asn His Ser Gln Val 
            500                 505                 510         


Val Gln Pro Val Thr Thr Thr Gly Pro Glu His Ser Lys Pro Leu Glu 
        515                 520                 525             


Lys Ser Asp Gly Leu Phe Ala Gln Asp Arg Asp Pro Arg Phe Ser Glu 
    530                 535                 540                 


Ile Tyr His Asn Ile Asn Ala Asp Gln Ser Lys Gly Ile Ser Ser Ser 
545                 550                 555                 560 


Thr Val Pro Ala Thr Gln Gln Leu Phe Ser Gln Gly Asn Thr Phe Pro 
                565                 570                 575     


Pro Thr Pro Arg Pro Ala Glu Asn Phe Arg Asn Ser Gly Leu Ala Pro 
            580                 585                 590         


Pro Val Thr Ile Val Gln Pro Ser Ala Ser Ala Gly Gln Met Leu Ala 
        595                 600                 605             


Gln Ile Ser Arg His Ser Asn Pro Thr Gln Gly Ala Thr Pro Thr Trp 
    610                 615                 620                 


Thr Pro Thr Thr Arg Ser Gly Phe Ser Ala Gln Gln Val Ala Thr Gln 
625                 630                 635                 640 


Ala Thr Ala Lys Thr Arg Thr Ser Gln Phe Gly Val Gly Ser Phe Gln 
                645                 650                 655     


Thr Pro Ser Ser Phe Ser Ser Met Ser Leu Pro Gly Ala Pro Thr Ala 
            660                 665                 670         


Ser Pro Gly Ala Ala Ala Tyr Pro Ser Leu Thr Asn Arg Gly Ser Asn 
        675                 680                 685             


Phe Ala Pro Glu Thr Gly Gln Thr Ala Gly Gln Phe Gln Thr Arg Thr 
    690                 695                 700                 


Ala Glu Gly Val Gly Val Trp Pro Gln Trp Gln Gly Gln Gln Pro His 
705                 710                 715                 720 


His Arg Ser Ser Ser Ser Glu Gln His Val Gln Gln Pro Pro Ala Gln 
                725                 730                 735     


Gln Pro Gly Gln Pro Glu Val Phe Gln Glu Met Leu Ser Met Leu Gly 
            740                 745                 750         


Asp Gln Ser Asn Ser Tyr Asn Asn Glu Glu Phe Pro Asp Leu Thr Met 
        755                 760                 765             


Phe Pro Pro Phe Ser Glu 
    770                 


<210>  36
<211>  870
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Thr Ala Asp Lys Glu Lys Lys Arg Ser Ser Ser Glu Arg Arg Lys 
1               5                   10                  15      


Glu Lys Ser Arg Asp Ala Ala Arg Cys Arg Arg Ser Lys Glu Thr Glu 
            20                  25                  30          


Val Phe Tyr Glu Leu Ala His Glu Leu Pro Leu Pro His Ser Val Ser 
        35                  40                  45              


Ser His Leu Asp Lys Ala Ser Ile Met Arg Leu Ala Ile Ser Phe Leu 
    50                  55                  60                  


Arg Thr His Lys Leu Leu Ser Ser Val Cys Ser Glu Asn Glu Ser Glu 
65                  70                  75                  80  


Ala Glu Ala Asp Gln Gln Met Asp Asn Leu Tyr Leu Lys Ala Leu Glu 
                85                  90                  95      


Gly Phe Ile Ala Val Val Thr Gln Asp Gly Asp Met Ile Phe Leu Ser 
            100                 105                 110         


Glu Asn Ile Ser Lys Phe Met Gly Leu Thr Gln Val Glu Leu Thr Gly 
        115                 120                 125             


His Ser Ile Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Ile Arg 
    130                 135                 140                 


Glu Asn Leu Ser Leu Lys Asn Gly Ser Gly Phe Gly Lys Lys Ser Lys 
145                 150                 155                 160 


Asp Met Ser Thr Glu Arg Asp Phe Phe Met Arg Met Lys Cys Thr Val 
                165                 170                 175     


Thr Asn Arg Gly Arg Thr Val Asn Leu Lys Ser Ala Thr Trp Lys Val 
            180                 185                 190         


Leu His Cys Thr Gly Gln Val Lys Val Tyr Asn Asn Cys Pro Pro His 
        195                 200                 205             


Asn Ser Leu Cys Gly Tyr Lys Glu Pro Leu Leu Ser Cys Leu Ile Ile 
    210                 215                 220                 


Met Cys Glu Pro Ile Gln His Pro Ser His Met Asp Ile Pro Leu Asp 
225                 230                 235                 240 


Ser Lys Thr Phe Leu Ser Arg His Ser Met Asp Met Lys Phe Thr Tyr 
                245                 250                 255     


Cys Asp Asp Arg Ile Thr Glu Leu Ile Gly Tyr His Pro Glu Glu Leu 
            260                 265                 270         


Leu Gly Arg Ser Ala Tyr Glu Phe Tyr His Ala Leu Asp Ser Glu Asn 
        275                 280                 285             


Met Thr Lys Ser His Gln Asn Leu Cys Thr Lys Gly Gln Val Val Ser 
    290                 295                 300                 


Gly Gln Tyr Arg Met Leu Ala Lys His Gly Gly Tyr Val Trp Leu Glu 
305                 310                 315                 320 


Thr Gln Gly Thr Val Ile Tyr Asn Pro Arg Asn Leu Gln Pro Gln Cys 
                325                 330                 335     


Ile Met Cys Val Asn Tyr Val Leu Ser Glu Ile Glu Lys Asn Asp Val 
            340                 345                 350         


Val Phe Ser Met Asp Gln Thr Glu Ser Leu Phe Lys Pro His Leu Met 
        355                 360                 365             


Ala Met Asn Ser Ile Phe Asp Ser Ser Gly Lys Gly Ala Val Ser Glu 
    370                 375                 380                 


Lys Ser Asn Phe Leu Phe Thr Lys Leu Lys Glu Glu Pro Glu Glu Leu 
385                 390                 395                 400 


Ala Gln Leu Ala Pro Thr Pro Gly Asp Ala Ile Ile Ser Leu Asp Phe 
                405                 410                 415     


Gly Asn Gln Asn Phe Glu Glu Ser Ser Ala Tyr Gly Lys Ala Ile Leu 
            420                 425                 430         


Pro Pro Ser Gln Pro Trp Ala Thr Glu Leu Arg Ser His Ser Thr Gln 
        435                 440                 445             


Ser Glu Ala Gly Ser Leu Pro Ala Phe Thr Val Pro Gln Ala Ala Ala 
    450                 455                 460                 


Pro Gly Ser Thr Thr Pro Ser Ala Thr Ser Ser Ser Ser Ser Cys Ser 
465                 470                 475                 480 


Thr Pro Asn Ser Pro Glu Asp Tyr Tyr Thr Ser Leu Asp Asn Asp Leu 
                485                 490                 495     


Lys Ile Glu Val Ile Glu Lys Leu Phe Ala Met Asp Thr Glu Ala Lys 
            500                 505                 510         


Asp Gln Cys Ser Thr Gln Thr Asp Phe Asn Glu Leu Asp Leu Glu Thr 
        515                 520                 525             


Leu Ala Pro Tyr Ile Pro Met Asp Gly Glu Asp Phe Gln Leu Ser Pro 
    530                 535                 540                 


Ile Cys Pro Glu Glu Arg Leu Leu Ala Glu Asn Pro Gln Ser Thr Pro 
545                 550                 555                 560 


Gln His Cys Phe Ser Ala Met Thr Asn Ile Phe Gln Pro Leu Ala Pro 
                565                 570                 575     


Val Ala Pro His Ser Pro Phe Leu Leu Asp Lys Phe Gln Gln Gln Leu 
            580                 585                 590         


Glu Ser Lys Lys Thr Glu Pro Glu His Arg Pro Met Ser Ser Ile Phe 
        595                 600                 605             


Phe Asp Ala Gly Ser Lys Ala Ser Leu Pro Pro Cys Cys Gly Gln Ala 
    610                 615                 620                 


Ser Thr Pro Leu Ser Ser Met Gly Gly Arg Ser Asn Thr Gln Trp Pro 
625                 630                 635                 640 


Pro Asp Pro Pro Leu His Phe Gly Pro Thr Lys Trp Ala Val Gly Asp 
                645                 650                 655     


Gln Arg Thr Glu Phe Leu Gly Ala Ala Pro Leu Gly Pro Pro Val Ser 
            660                 665                 670         


Pro Pro His Val Ser Thr Phe Lys Thr Arg Ser Ala Lys Gly Phe Gly 
        675                 680                 685             


Ala Arg Gly Pro Asp Val Leu Ser Pro Ala Met Val Ala Leu Ser Asn 
    690                 695                 700                 


Lys Leu Lys Leu Lys Arg Gln Leu Glu Tyr Glu Glu Gln Ala Phe Gln 
705                 710                 715                 720 


Asp Leu Ser Gly Gly Asp Pro Pro Gly Gly Ser Thr Ser His Leu Met 
                725                 730                 735     


Trp Lys Arg Met Lys Asn Leu Arg Gly Gly Ser Cys Pro Leu Met Pro 
            740                 745                 750         


Asp Lys Pro Leu Ser Ala Asn Val Pro Asn Asp Lys Phe Thr Gln Asn 
        755                 760                 765             


Pro Met Arg Gly Leu Gly His Pro Leu Arg His Leu Pro Leu Pro Gln 
    770                 775                 780                 


Pro Pro Ser Ala Ile Ser Pro Gly Glu Asn Ser Lys Ser Arg Phe Pro 
785                 790                 795                 800 


Pro Gln Cys Tyr Ala Thr Gln Tyr Gln Asp Tyr Ser Leu Ser Ser Ala 
                805                 810                 815     


His Lys Val Ser Gly Met Ala Ser Arg Leu Leu Gly Pro Ser Phe Glu 
            820                 825                 830         


Ser Tyr Leu Leu Pro Glu Leu Thr Arg Tyr Asp Cys Glu Val Asn Val 
        835                 840                 845             


Pro Val Leu Gly Ser Ser Thr Leu Leu Gln Gly Gly Asp Leu Leu Arg 
    850                 855                 860                 


Ala Leu Asp Gln Ala Thr 
865                 870 


